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Parkin Antibody (D-1): sc-133167
- Parkin Antibody (D-1) is a mouse monoclonal IgG1 κ, cited in 12 publications, provided at 200 µg/ml
- raised against amino acids 61-360 mapping within an internal region of Parkin of human origin
- Anti-Parkin Antibody (D-1) is recommended for detection of Parkin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Parkin Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Parkin (D-1): sc-133167.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Parkin Antibody (D-1) for WB applications. This reagent is now offered in a bundle with Parkin Antibody (D-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Parkin Antibody (D-1) is an IgG1 κ mouse monoclonal Parkin antibody (also designated Parkin antibody or PRKN antibody) that detects Parkin of mouse, rat and human origin by WB, IP, IF and ELISA. Parkin Antibody (D-1) is available as the non-conjugated anti-Parkin antibody form, as well as multiple conjugated forms of anti-Parkin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2-27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms. Mutations in the Parkin gene are responsible for autosomal recessive juvenile Parkinson′s disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution.
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