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Phospho-ITGB1 (Thr788) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA538256
Description
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.Specifications
Phospho-ITGB1 (Thr788) | |
Polyclonal | |
Unconjugated | |
ITGB1 | |
Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29, ITGB1, FNRB, MDF2, MSK12 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
16412, 24511, 3688 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P05556, P09055, P49134 | |
ITGB1 | |
A synthetic phosphopeptide derived from human integrin beta1 around the phosphorylation site of Thr788 (A-V-TP-T-V) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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