Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)

Mca-Pro-Leu-Ala-Gln-Ala-Val-Dap(Dnp)-Arg-Ser-Ser-Ser-Arg-NH₂

Product Number: 4031302

CAS Number: 192723-42-5

€ 223.60 – € 892.40

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Product Description

Mca-PLAQAV-Dpa-RSSSR-amide, a fluorogenic (FRET) peptide substrate for tumor necrosis factor (TNF) converting enzyme (TACE, ADAM-17 endopeptidase).

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Amyloid Beta Peptides & Alzheimer's Disease
Processing of tumour necrosis factor-alpha precursor by metalloproteinases.

A.J.H.Gearing et al., Nature, 370, 555 (1994)

COMPARISON OF SNAKE VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES AS MODELS OF TNF-α CONVERTING ENZYME.

D.E.Van Dyk et al., Bioorg. Med. Chem. Lett., 7, 1219 (1997)

M.E.Powers et al., Cell Host Microbe, 17, 775 (2015)

Salt form: Trifluoroacetate

Molecular weight: 1638.72

Sum Formula: C₆₉H₁₀₃N₂₃O₂₄

Storage Temperature: < -15°C

Synonyms: Mca-(endo-1a-Dap(Dnp))-TNF-a (-5 to +6) amide (human)

One Letter code: Mca-PLAQAV-Dpa-RSSSR-NH₂

Source: Synthetic

Old Product Number: M-2255

Substrates
Tumor Necrosis Factor (TNF) Convertase
Matrix Metalloproteinase-12 (MMP-12)
ADAM17 Endopeptidase
ADAM10 Endopeptidase

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