WO2017178612A1

WO2017178612A1 - Method of stratification of patients suffering from cancer

Info

Publication number: WO2017178612A1
Application number: PCT/EP2017/058983
Authority: WO
Inventors: Patrick Brest; Christine MALOT
Original assignee: Institut National De La Sante Et De La Recherche Medicale (Inserm); Centre National De La Recherche Scientifique; Universite De Nice Sophia Antipolis
Priority date: 2016-04-13
Filing date: 2017-04-13
Publication date: 2017-10-19

Abstract

The present invention relates to methods for stratifying patients suffering from cancer. There is a need of understanding the influence of the different cell subpopulations of the tumoral environment on tumor evolution. However, specifically separating and studying each cell subpopulation of a specific stroma tumoral environment would necessitate important costs and time. By studying a cohort of 676 patients, the inventors showed that it is possible to provide an in silico molecule microdissection approach to model the global gene expression pattern of patients suffering from cancer, in particular suffering from NSCLC, according to the gene expression pattern of each cell subpopulation of associated tumoral stroma, thereby determining a prognosis in patients suffering from lung cancer. In particular, the present invention concerns a method for determining prognosis of a patient suffering from cancer comprising a modeling step of the global transcriptional expression level pattern of genes from a biological sample from the tumor of the patient according to the transcriptional expression level patterns of said genes in 9 cell subpopulations or 7 groups of cell subpopulations from the tumor stromal environment.

Description

Method of stratification of patients suffering from cancer

The present invention concerns a method for stratifying patients suffering from cancer.

Lung cancer is the leading cause of cancer-related deaths in the word. Despite the different therapeutic strategies developed to date, non-small cell lung carcinoma (NSCLC), which represents 80% of lung cancers, has a poor prognosis since the overall survival (OS) rate after 5 years is less than 25% for all stages. Studying and understanding lung tumoral evolution is thus a major public health issue.

Until now, anatomic extension of tumor was the most powerful tool to predict the prognosis of patients suffering from NSCLC. It has been recently demonstrated that the immune microenvironment of primary tumors was a factor of prognosis of overall survival and survival without disease. In colon cancer, an immunoscore based on microscopic quantifications was shown as being predictive for the prognosis of patients.

Accordingly, tumor microenvironment could be a prognostic marker, as well as a therapeutic target, in patients suffering from cancer.

However, in cancer biology, numerous interactions between the tumor and the host immune system exist. Carcinoma cells are tightly associated with extracellular matrix, mesenchymatous cells, immune and vascular cells. In some cases, this environment is essential to the onset or development of tumors while in other cases it prevents tumorigenesis or even ensures tumoral clearance.

Accordingly, there is an important need of understanding the influence of the different cell subpopulations of the tumoral environment on tumor evolution. However, specifically separating and studying each cell subpopulation of a specific stroma tumoral environment would necessitate important costs and time.

There is thus an important need of methods enabling assessing the influence of each cell subpopulation of a stroma associated with a tumoral biological complex from said tumoral biological complex.

The present invention meets this need. It arises from the unexpected findings by the inventors that it is possible to provide an in silico molecule microdissection approach to model the global gene expression pattern of patients suffering from cancer, in particular suffering from NSCLC, according to the gene expression pattern of each cell subpopulation of associated tumoral stroma, thereby determining the influence of each cell subpopulation on the global expression pattern. The present invention thus concerns a method for determining prognosis of a patient suffering from cancer, comprising:

A) determining the global transcriptional expression level pattern Y of at least N genes in a biological sample from the tumor of said patient, wherein N is an integer≥ 9;

B) providing the transcriptional expression level X^G) of said at least N genes from biological samples from s cell subpopulations j or groups of cell subpopulations from a tumor stromal environment, wherein s is an integer≥ 7 and < N,

C) modeling said global transcriptional expression level pattern Y of n genes, wherein s<n<N, according to the transcriptional expression level pattern X^G) of said genes in said s cell subpopulations or groups of cell subpopulations according to the following equation

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

3j is the estimated coefficient associated with the j^th subpopulation or group of subpopulations,

X^G) is the transcriptional expression level pattern of said n genes in the j^th subpopulation or group of subpopulations,

by estimating the estimated coefficients by partial deconvolution using the least squares method or the ridge method,

D) based on the coefficients estimated in step C), determining whether said patient has a good or poor prognosis.

Another object of the invention concerns a method for stratifying patients suffering from cancer based on the transcriptomic pattern of cell subpopulations from their tumor stromal environment, comprising:

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

D) on the basis of the coefficients estimated in step C), stratifying said patients according to the transcriptomic profile of cell subpopulations from their tumor stromal environment.

A further object of the invention concerns a method for selecting a patient suffering from cancer for an anticancerous therapy targeting a specific cell subpopulation from tumor stromal environment, comprising:

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant, 3j is the estimated coefficient associated with the j subpopulation or group of subpopulations,

D) on the basis of the coefficients estimated in step C), selecting said patient for an anticancerous therapy targeting a specific cell subpopulation from tumor stromal environment.

The present invention also concerns a method for determining the response of a patient suffering from cancer to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment, comprising:

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

by estimating the estimated coefficients by partial deconvolution using the least squares method or the ridge method, D) based on the coefficients estimated in step C), determining the response of said patient to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment.

The present invention will be described in more details with reference to the case where 9 cell subpopulations are contemplated (s=9). It will be understood that when s is >9, the s cell subpopulations may typically include the 9 cell subpopulations described herein after.

According to a specific embodiment, the present invention thus concerns a method for determining prognosis of a patient suffering from cancer, comprising:

A) determining the global transcriptional expression level pattern Y of at least N genes in a biological sample from the tumor of said patient, wherein N is an integer≥ 9,

B) providing the transcriptional expression level X^G) of said at least N genes from biological samples from the following 9 cell subpopulations j from a tumor stromal environment: epithelial cells, fibroblasts, vessels endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), CD56 cells (NK cells), CD8 cells, eosinophils and neutrophils, wherein said cell subpopulations may optionally be gathered into the following 7 groups of cell subpopulations from a tumor environment: epithelial cells, fibroblasts, vessel endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), the group consisting of CD56 cells (NK cells) and CD8 cells, and the group consisting of eosinophils and neutrophils,

C) modeling said global transcriptional expression level pattern Y of n genes, wherein 9<n<N, according to the transcriptional expression level pattern X® of said genes in said 9 cell subpopulations according to the following equation

v— ø __. a v vepithelial , <> _v γ fibroblasts ■ a v v vessels , o ϊ — p₀ 1- p epitheli l ^{x Λ} ' P fibroblasts ^{x A "}·^" P vessels * ^Λ ' PCD l*

X X^{CB l4} + ?CD19 X X^CD19 + ficDS X X^CB56 + β_εΒΒ X X^cm fi_e0Si_nOpMls v eosinophils o _v yne trophils

-r Pttetitrophlls ^Λ

or, when the cell subpopulations are gathered into 7 groups of cell subpopulations, according to the transcriptional expression level pattern X® of said genes in said 7 groups of cell subpopulations according to the following equation

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant, 3e_Pitheiiai is the estimated coefficient associated with the epithelial cells subpopulation, ^epithelial jg ^_e transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3fibrobiasts is the estimated coefficient associated with the fibroblasts subpopulation, ^fibroblasts j_s ^_e transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3_Vesseis is the estimated coefficient associated with the vessels endothelial cells subpopulation,

^vessels j_s ^_e transcriptional expression level pattern of said n genes in the vessels endothelial cells subpopulation,

3CDI4 is the estimated coefficient associated with the CD14 cells (monocytes) subpopulation,

X^CD14 is the transcriptional expression level pattern of said n genes in the CD14 cells (monocytes) subpopulation,

3CDI9 is the estimated coefficient associated with the CD19 cells (B cells) subpopulation,

X^CD19 is the transcriptional expression level pattern of said n genes in the CD19 cells (B cells) subpopulation,

3CD56 is the estimated coefficient associated with the CD56 cells (NK cells) subpopulation,

X^CD56 is the transcriptional expression level pattern of said n genes in the CD56 cells (NK cells) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation, X^CD8 is the transcriptional expression level pattern of said n genes in the CD8 cells subpopulation,

3eosinophiis is the estimated coefficient associated with the eosinophils subpopulation, ^eosinophils j_s ^_e transcriptional expression level pattern of said n genes in the eosinophils subpopulation,

3neutrophiis is the estimated coefficient associated with the neutrophils subpopulation, ^neutrophils jg ^_e transcriptional expression level pattern of said n genes in the neutrophils subpopulation,

3CD56+CD8 is the estimated coefficient associated with the group consisting of the CD56 cells (NK cells) and the CD8 cells subpopulations,

X^CD56+CD8 is the transcriptional expression level pattern of said n genes in the group consisting of the CD56 cells (NK cells) and the CD8 cells subpopulations, 3eosino+neutro is the estimated coefficient associated with the group consisting of the eosinophils and the neutrophils subpopulations,

^eosino+neutro j_s ^_e transcriptional expression level pattern of said n genes in the group consisting of the eosinophils and neutrophils subpopulations,

D) based on the coefficients estimated in step C), determining whether said patient has a good or poor prognosis. Another object of the invention concerns a method for stratifying patients suffering from cancer based on the transcriptomic pattern of cell subpopulations from their tumor stromal environment, comprising:

A) determining the global transcriptional expression level pattern Y of at least N genes in a biological sample from the tumor of said patients, wherein N is an integer≥ 9 B) providing the transcriptional expression level X^G) of said at least N genes from biological samples from the following 9 cell subpopulations j from a tumor stromal environment: epithelial cells, fibroblasts, vessels endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), CD56 cells (NK cells), CD8 cells, eosinophils and neutrophils, wherein said cell subpopulations may optionally be gathered into the following 7 groups of cell subpopulations from a tumor environment: epithelial cells, fibroblasts, vessel endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), the group consisting of CD56 cells (NK cells) and CD8 cells, and the group consisting of eosinophils and neutrophils,

v— a a v vepitheiial < o v fibroblasts , a _v ^vessels , a r p.₀ + p epithelial fibroblasts Pvessels ^Λ PCI

X X^{CD 14} + ?CD19 ^x X^{CD lB} + βα056, X X^"C0S6 + ficDB X X^C[>B + fieostnopklls yeoslnaphils _v y7ieutrophtls

^' ' ^neutrophils ^{Λ Λ}

V a i ff v v-eplthelial i o _v γ fibroblasts ■ o _v vesseis ■ a

X A pcDi A -r pcBSB+CDS ^{x Λ} + P sh +nemtro v yeosino+neutro

wherein Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

3epitheiiai is the estimated coefficient associated with the epithelial cells subpopulation,

^epithelial j_s ^_e transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3fibrobiasts is the estimated coefficient associated with the fibroblasts subpopulation, fibroblasts j_s ^_e transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3CDI4 is the transcriptional estimated coefficient associated with the CD14 cells (monocytes) subpopulation,

X^CD14 is the transcriptional expression level pattern of said n genes in the CD14 cells

(monocytes) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

X^CD8 is the transcriptional expression level pattern of said n genes in the CD8 cells subpopulation,

3CD56+CD8 is the estimated coefficient associated with the group consisting of the CD56 cells (NK cells) and the CD8 cells subpopulations, X^CD56+CD8 is the transcriptional expression level pattern of said n genes in the group consisting of the CD56 cells (NK cells) and the CD8 cells subpopulations,

3eosino+neutro is the estimated coefficient associated with the group consisting of the eosinophils and the neutrophils subpopulations,

A) determining the global transcriptional expression level pattern Y of at least N genes in a biological sample from the tumor of said patients, wherein N is an integer≥ 9

y 6 4- 1? v veplthelial , a _v y f ibroblasts . a _v yoessels . a

* - Po + Pepltheltal ^{x Λ} + P fibroblasts ^{x A +} P vessels ^{x Λ +} PCD 14

^X X^CDl* + fetl9 ^x X^{CD l9} + fieDS6 ^x X^CD36 + (icon X X^COfl + β_βοΕΐηορΜΙ$ v yeesinep Is o yneutrophtls

T Pfieutre-phUs ^A or, when the cell subpopulations are gathered into 7 groups of cell subpopulations, according to the transcriptional expression level pattern X® of said genes in said 7 groups of cell subpopulations according to the following equation I — po + p epithelial ^{κ Λ +} fi blmts ^{x Λ} + Pvessete ^{Χ Λ} + PCD

K A -t pc .9 *^■* T PCDSS+CDS » Λ ^"Γ PeBstee+mMire v yeosiBO+iientre

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

^epithelial j_s ^_Q transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3fibrobiasts is the estimated coefficient associated with the fibroblasts subpopulation, ^fibroblasts j_s ^_Q transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

^vessels j_s ^_Q transcriptional expression level pattern of said n genes in the vessels endothelial cells subpopulation,

3CDI4 is the transcriptional estimated coefficient associated with the CD14 cells

(monocytes) subpopulation,

X^CD56 is the transcriptional expression level pattern of said n genes in the CD56 cells

(NK cells) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

3eosinophiis is the estimated coefficient associated with the eosinophils subpopulation,

^eosinophils j_s ^_Q transcriptional expression level pattern of said n genes in the eosinophils subpopulation,

X^CD56+CD8 is the transcriptional expression level pattern of said n genes in the group consisting of the CD56 cells (NK cells) and the CD8 cells subpopulations,

^eosmo+neutro j_s ^_e transcriptional expression level pattern of said n genes in the group consisting of the eosinophils and neutrophils subpopulations,

y 6 4- 1? v veplthelial , a _v y f ibroblasts . a _v yoessels . a

T PfieutrephUs ^A or, when the cell subpopulations are gathered into 7 groups of cell subpopulations, according to the transcriptional expression level pattern X® of said genes in said 7 groups of cell subpopulations according to the following equation

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

3epitheiiai is the estimated coefficient associated with the epithelial cells subpopulation, ^epithelial j_s ^_e transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

(NK cells) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

3eosinophiis is the estimated coefficient associated with the eosinophils subpopulation, ^eosinophils jg ^_e transcriptional expression level pattern of said n genes in the eosinophils subpopulation,

3neutrophiis is the estimated coefficient associated with the neutrophils subpopulation,

^neutrophils j_s ^_e transcriptional expression level pattern of said n genes in the neutrophils subpopulation,

D) based on the coefficients estimated in step C), determining the response of said patient to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment. Detailed description of the invention

Definitions

The "patient" according to the invention may be a non-human (such a dog, a cat or a monkey) or human mammal. Preferably, said patient is human.

The patient according to the invention suffers from cancer. Preferably, the patient suffers from lung or breast cancer. More preferably, the patient suffers from lung cancer.

More particularly, the patient suffers from non-small cell lung cancer.

By "non-small cell lung cancer", "non-small cell lung carcinoma" or "NSCLC" is meant herein any type of epithelial lung cancer other than small cell lung carcinoma. NSCLC include lung adenocarcinoma (ADC), squamous cell carcinoma (SCC) and large cell carcinoma. Preferably, the patient suffers from lung adenocarcinoma or squamous cell carcinoma.

Non-small cell lung cancer can be characterized by a stage, in particular according to the TNM classification. Lung cancer staging is the assessment of the extent to which a lung cancer has spread from its original source. The TNM classification is based on the size of the primary tumor, lymph node involvement, and distant metastasis. After this, using the TNM descriptors, a group is assigned, ranging from occult cancer, through stage 0, IA, IB, IIA, MB, MIA, NIB to IV, as follows:

IA: Primary tumor is <2 cm in greatest dimension.

IB: Primary tumor is >2 but <3 cm in greatest dimension.

IIA: Primary tumor is >3 and <5 cm in greatest dimension.

MB: Primary tumor is >5 and <7 cm in greatest dimension.

Ill size: Primary tumor is >7 cm in greatest dimension;

III inv: Primary tumor invades the chest wall, diaphragm, phrenic nerve, mediastinal pleura, or pericardium;

III centr: Primary tumor is <2cm to the carina or there is atelectasis of the entire lung;

III satell: Primary tumor is associated with separate tumor nodule(s) in same pulmonary lobe;

IV inv: Tumor invading the heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, or spine;

IV ipis: Tumor of any size with additional tumor nodule(s) in a different ipsilateral lobe.

Preferably, the patient suffers from stage I or II adenocarcinoma or squamous cell carcinoma.

By "tumor stromal environment" or "turmor stromal microenvironment" is meant the compilation of cells surrounding a tumor, including fibroblasts/myofibroblasts, glial, epithelial, fat, immune, vascular, smooth muscle and immune cells along with the extracellular matrix (ECM) and extracellular molecules. While none of these cells are themselves malignant, due to their environment, their interactions with each other, and directly or indirectly with the cancer cells, they acquire an abnormal phenotype and altered function.

By "cell subpopulation from a tumor stromal environment" is meant herein a population of cells from a same type present in the tumor stromal environment, as defined above. Such cell subpopulations include the epithelial cells subpopulation, the fibroblasts subpopulation, the vascular cells or vessels endothelial cells subpopulations, the immune cells subpopulation including the CD14 cells (monocytes) subpopulation, the CD19 cells (B cells) subpopulation, the CD56 cells (NK cells) subpopulation, the CD8 cells (T cells) subpopulation, the eosinophils subpopulation, the neutrophils subpopulation, the plasmacytoid dendritic cells (pDC) subpopulation and the myeloid dendritic cells (mDC) subpopulation. In the context of the invention, the "epithelial cells subpopulation" of a tumor stromal environment preferably refers to an epithelial cells subpopulation of a lung tumor stromal environment. In a particular embodiment, said epithelial cells subpopulation is a population of lung epithelial cells, more preferably of lung bronchial epithelial cells, still preferably of primary lung bronchial epithelial cells, in particular of well-differentiated primary human lung bronchial epithelial cells, most preferably of well-differentiated NHBE cells (wdNHBE cells) such as the primary wd-NHBE cells EpiAirway PC-12 commercialized by MatTek Corporation.

In the context of the invention, the "fibroblasts subpopulation" of a tumor stromal environment refers to activated fibroblasts or myofibroblasts present in the tumor stroma, which produce relevant signal mediators, such as growth factos, cytokines, chemokines and other immune modulators. Such activated fibroblasts are also called peritumoral fibroblasts or CAFs.

Preferably, said fibroblast subpopulation is a fibroblasts subpopulation of a lung tumor stromal environment. In a particular embodiment, said fibroblasts subpopulation is a population of lung fibroblasts, in particular of lung fibroblasts from subjects with rapid or slow progressing idiopathic pulmonary fibrosis.

In the context of the invention, the "vascular cells subpopulation" or "vessels endothelial cells subpopulation" of a tumor stromal environment refers to cells from tumor vessels formed as a result of tumor angiogenesis.

Preferably, said vessels endothelial cells subpopulation is an endothelial cells subpopulation of a lung or breast tumor stromal environment. In a particular embodiment, said vessels endothelial cell subpopulation is a population of endothelial cells from breast cancer, in particular of endothelial cells after incubation with breast cancer cells, more particularly of endothelial cells after incubation from breast cancer cells MDA-MB231 .

In the context of the invention, the "immune cells subpopulation" of a tumor stromal environment refers to immune cells, including CD14 cells (monocytes), CD19 cells (B cells), CD56 cells (NK cells), CD8 cells (T cells), eosinophils, neutrophils, plasmacytoid dendritic cells (pDC) and myeloid dendritic cells (mDC), from blood circulating in the tumor environment.

In the context of the invention, the "CD14 cells subpopulation" or "monocytes subpopulation" of a tumor stromal environment refers to immune cells, from blood preferably circulating in the tumor environment, expressing the CD14 cell surface receptor at their surface.

Preferably, said CD14 cells subpopulation is a CD14 cells subpopulation from a blood sample from a healthy subject or a subject suffering from cancer. In the context of the invention, the "CD19 cells subpopulation" or "B cells subpopulation" of a tumor stromal environment refers to immune cells, from blood preferably circulating in the tumor environment, expressing the CD19 cell surface receptor at their surface.

Preferably, said CD19 cells subpopulation is a CD19 cells subpopulation from a blood sample from a healthy subject or a subject suffering from cancer.

In the context of the invention, the "CD56 cells subpopulation" or "NK cells subpopulation" of a tumor stromal environment refers to immune cells, from blood preferably circulating in the tumor environment, expressing the CD56 cell surface receptor at their surface.

Preferably, said CD56 cells subpopulation is a CD56 cells subpopulation from a blood sample from a healthy subject or a subject suffering from cancer.

In the context of the invention, the "CD8 cells subpopulation" or "T cells subpopulation" of a tumor stromal environment refers to immune cells, from blood preferably circulating in the tumor environment, expressing the CD8 cell surface receptor at their surface.

Preferably, said CD8 cells subpopulation is a CD8 cells subpopulation from a blood sample from a healthy subject or a subject suffering from cancer.

In the context of the invention, the "eosinophils subpopulation" of a tumor stromal environment refers to granulocyte immune cells, from blood preferably circulating in the tumor environment, which are brick-red colored after staining with eosin using the Romanowsky method.

Preferably, said eosinophils subpopulation is an eosinophils subpopulation from a blood sample from a healthy subject or a subject suffering from cancer.

In the context of the invention, the "neutrophils subpopulation" of a tumor stromal environment refers to granulocyte immune cells, from blood preferably circulating in the tumor environment, which are neutral pink colored after staining with eosin using the Romanowsky method and which contain a nucleus generally divided into 2-5 lobes.

Preferably, said neutrophils subpopulation is a neutrophils subpopulation from a blood sample from a healthy subject or a subject suffering from cancer.

In the context of the invention, the "plasmacvtoid dendritic cells subpopulation" or "pDC subpopulation" of a tumor stromal environment refers to immune cells, from blood preferably circulating in the tumor environment, which express the surface markers CD123, CD303 and CD304 but do not express high levels of CD1 1 c or CD14.

Preferably, said pDC subpopulation is a pDC subpopulation from a blood sample from a healthy subject or a subject suffering from cancer. In the context of the invention, the "myeloid dendritic cells subpopulation" or "rnPC subpopulation" of a tumor stromal environment refers to immune cells, from blood preferably circulating in the tumor environment, which express the surface markers CD1 c and CD1 1 c but do not express high levels of CD14.

Preferably, said mDC subpopulation is a mDC subpopulation from a blood sample from a healthy subject or a subject suffering from cancer.

By "transcriptional expression level of a gene" is meant herein the level of mRNAs, expressed from a gene, present in a sample.

By "global transcriptional expression level pattern Y of N genes in a biological sample" is meant herein the total transcriptional expression levels of said genes in the studied biological sample, cumulating the transcriptional expression levels of said genes from all the cells, in particular all the cell subpopulations, present in the studied biological sample.

By "transcriptional expression level Χ^ϋ) of N genes in a biological sample from a cell subpopulation /" is meant herein the transcriptional expression levels of said genes in a biological sample representative of said cell subpopulation j, as defined above.

Step A) of determining global transcriptional expression level pattern Y The methods of the invention comprise a step A) of determining the global transcriptional expression level pattern Y of at least N genes, as defined in the section "Definitions" above, in a biological sample from the tumor of the studied patient, wherein N is an integer≥ 9.

The transcriptional expression levels of genes may in general be determined by detecting mRNA from the cells of the biological sample.

Any method to measure the expression level may be used, including but not limited to microarray analysis, quantitative PCR, RNA sequencing (RNA-seq) or southern analysis. In a preferred embodiment, the global transcriptional expression level Y may be obtained in step A) using a DNA microarray, such as DNA microarrays commercialized by Affymetrix, for example the whole human genome expression microarray Affymetrix U133 Plus 2.0 which covers about 47000 transcripts and variants. In another preferred embodiment, the global transcriptional expression level Y may be determined using quantitative PCR. In still another embodiment, the global transcriptional expression level Y may be determined using RNA sequencing (RNA-seq or whole transcriptome shotgun sequencing) In any case, the expression level of any gene is preferably normalized. Preferably, the number N of genes that transcriptional expression levels of which is determined is superior to 10, more preferably superior to 50, to 100, to 150, to 200, to 250, to 300, to 350, to 400, to 450, to 500, to 550, to 600, to 650, to 700, to 750, to 800, to 850, to 900, to 950, to 1000, to 2000, to 3000, to 4000, to 5000, to 6000, to 7000, to 8000, to 9000, to 10000, to 1 1000, to 12000, to 13000, to 14000, to 15000, to 16000, to 17000, to 18000, to 19000, to 20000, to 21000, to 22000, to 23000, to 24000, to 25000, to 26000, to 27000, to 28000, to 29000, to 30000, to 31000, to 32000, to 33000, to 34000, to 35000, to 36000, to 37000, to 38000, to 39000, to 40000, to 41000, to 42000, to 43000, to 44000, to 45000, to 46000, to 47000, to 48000, to 49000, to 50000, to 51000, to 52000, to 53000, to 54000 or to 55000. More preferably, N is superior to 54500. Most preferably, N is 54675.

Preferably, said N genes are the genes which can be detected by the DNA microarrays commercialized by Affymetrix, in particular by the whole human genome expression microarray Affymetrix U133 Plus 2.0. Preferably, said N genes are the genes listed on the Platform GPL570 of the GEO Database of 7 November 2003.

Step B) of providing transcriptional expression levels Xfⁱ⁾ The methods of the invention comprise a step B) of providing the transcriptional expression level X^G) of the at least N genes, as defined above, from biological samples from the following 9 cell subpopulations j from a tumor stromal environment: epithelial cells, fibroblasts, vessels endothelial cells, CD14 cells, CD19 cells, CD56 cells, CD8 cells, eosinophils and neutrophils, as defined in the section "Definitions" above, wherein said cell subpopulations may optionally be gathered into the following 7 groups of cell subpopulations from a tumor environment: epithelial cells, fibroblasts, vessel endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), the group consisting of CD56 cells (NK cells) and CD8 cells, and the group consisting of eosinophils and neutrophils.

Said transcriptional expression levels X^G) can be provided by determining the transcriptional expression levels X^G) of said N genes in biological samples from said 9 cell subpopulations using the techniques disclosed in the section "Section A) of determining global transcriptional expression level pattern Y", by using publicly available transcriptional expression levels X® of said N genes from biological samples from said 9 cell subpopulations or said 7 groups of cell subpopulations, or by a combination of both.

Publicly available transcriptional expression levels of genes from biological samples from epithelial cells, fibroblasts, vessels endothelial cells, CD14 cells, CD19 cells, CD56 cells, CD8 cells, eosinophils and/or neutrophils subpopulations can be obtained for example from public database, such as the GEO DataSets database. Preferably, transcriptional expression levels X® from several biological samples, for each cell subpopulation, are provided. For example, transcription expression levels X® from 3 to 50 biological samples are provided, preferably from 4 to 47, from 5 to 40, from 6 to 35, from 7 to 30, from 8 to 25, from 9 to 20, from 10 to 19, from 1 1 to 18, from 12 to 17, from 13 to 16 or from 14 to 15 biological samples are provided. The number of biological samples may be identical or different according to the cell subpopulation or group of cell subpopulations.

In a particular embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the epithelial cells subpopulation are those of the dataset GSE 48466 of 3 July 2013 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 12 biological samples are provided, typically from the samples GSM 1 179364, GSM 1 179365, GSM1 179366, GSM1 179367, GSM1 179368, GSM1 179369, GSM1 179370, GSM1 179371 , GSM1 179372, GSM1 179373, GSM1 179374, GSM1 179375 of the dataset GSE 48466 of 3 July 2013 from the GEO DataSets database.

In another particular embodiment, the transcriptional expression levels X⁽ⁱ⁾ of the at least N genes from biological samples from the fibroblasts cells subpopulation are those of the dataset GSE 44723 of 10 April 2013 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 14 biological samples are provided, typically from the samples GSM1089614, GSM1089615, GSM1089616, GSM1089617, GSM1089618, GSM1089619, GSM1089620, GSM1089621 , GSM1089622, GSM1089623, GSM1089624, GSM1089625, GSM1089626 and GSM1089627 of the dataset GSE 44723 of 10 April 2013 from the GEO DataSets database.

In another particular embodiment, the transcriptional expression levels X⁽ⁱ⁾ of the at least N genes from biological samples from the vessels endothelial cells subpopulation are those of the dataset GSE 48786 of 31 December 2013 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 6 biological samples are provided, typically from the samples GSM1 184603, GSM1 184604, GSM1 184605, GSM1 184606, GSM1 184607 and GSM1 184608 of the dataset GSE 48786 of 31 December 2013 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the immune cells subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 47 biological samples are provided, typically from the samples GSM705287, GSM705288, GSM705289, GSM705290, GSM705291 , GSM705292, GSM705293, GSM705294, GSM705295, GSM705296, GSM705297, GSM705298, GSM705299, GSM705300, GSM705301 , GSM705302, GSM705303, GSM705304, GSM705305, GSM705306, GSM705307, GSM705308, GSM705309, GSM705310, GSM70531 1 , GSM705312, GSM705313, GSM705314, GSM705315, GSM705316, GSM705317, GSM705318, GSM705319, GSM705320, GSM705321 , GSM705322, GSM705323, GSM705324, GSM705325, GSM705326, GSM705327, GSM705328, GSM705329, GSM705330, GSM705331 , GSM705332 and GSM705333 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the CD14 cells subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 10 biological samples are provided, typically from the samples GSM705287, GSM705288, GSM705289, GSM705290, GSM705291 , GSM705292, GSM705293, GSM705294, GSM705295 and GSM705296 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the CD19 cells subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 5 biological samples are provided, typically from the samples GSM705297, GSM705298, GSM705299, GSM705300 and GSM705301 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the CD56 cells subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 5 biological samples are provided, typically from the samples GSM705307, GSM705308, GSM705309, GSM705310 and GSM70531 1 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the CD8 cells subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 5 biological samples are provided, typically from the samples GSM705312, GSM705313, GSM705314, GSM705315 and GSM705316 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the eosinophils subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 4 biological samples are provided, typically from the samples GSM705317, GSM705318, GSM705319 and GSM705320 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

In still another embodiment, the transcriptional expression levels X® of the at least N genes from biological samples from the neutrophils subpopulation are those of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database. Preferably, in that case, the transcriptional expression levels X® from 3 biological samples are provided, typically from the samples GSM705326, GSM705327 and GSM705328 of the dataset GSE 28490 of 31 January 2012 from the GEO DataSets database.

Step C) of modeling

The methods of the invention comprise a step C) of modeling the global transcriptional expression level pattern Y of n genes, wherein 9<n<N, determined in step A), according to the transcriptional expression level pattern X® of said genes in said 9 cell subpopulations, determined in step B), according to the following equation:

-r Pttetitrophlls ^Λ

r — At + P epithelial X * ^¥ + Pfibrobl ts X * + P't ssels X * + Pcm.4 v wCDt* i a v YCD19 , O v YCDS6+CDB t O

X A ψ CB19 Χ Λ " PCB56+CBB ^{K A} ' P simo*mmiro v yeeias+«i§atre

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

3epitheiiai is the estimated coefficient associated with the epithelial cells subpopulation, ^epithelial j_s ^_Q transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3fibrobiasts is the estimated coefficient associated with the fibroblasts subpopulation, fibroblasts jg ^_e transcriptional expression level pattern of said n genes in the epithelial cells subpopulation,

3CDI 4 is the estimated coefficient associated with the CD14 cells (monocytes) subpopulation,

3CDI 9 is the estimated coefficient associated with the CD19 cells (B cells) subpopulation,

xCD56+cD8 j_s transcriptional expression level pattern of said n genes in the group consisting of the CD56 cells (NK cells) and the CD8 cells subpopulations,

^eosmo+neutro jg ^_e transcriptional expression level pattern of said n genes in the group consisting of the eosinophils and neutrophils subpopulations, by estimating the estimated coefficients by partial deconvolution using the least squares method or the ridge method.

By "partial deconvolution" is meant herein a mathematical approach to decompose the global transcriptional expression level pattern obtained from complex heterogenous tissues into subpatterns from specific cell subpopulations. Partial deconvolution aims at estimating proportions (or coefficients) from known transcriptional expression levels.

In the context of the present invention, the partial deconvolution approach is carried out using the least squares method or the ridge method.

By "least squares method" is meant herein an approach in regression analysis to the approximate solution of overdetermined systems, i.e., sets of equations in which there are more equations than unknowns. "Least squares" means that the overall solution minimizes the sum of the squares of the errors made in the results of every single equation.

The objective consists of adjusting the parameters of a model function to best fit a data set. A simple data set consists of n points (data pairs) (x„ yj i=1 ,...,n, where x, is an independent variable and y, is a dependent variable whose value is found by observation. The model function has the form ί(χ,β), where m adjustable parameters are held in the vector j8. The goal is to find the parameter values for the model which "best" fits the data. The least squares method finds its optimum when the sum, S, of squared residuals

is a minimum. A residual is defined as the difference between the actual value of the dependent variable and the value predicted by the model.

n = 7i - /(*». ø)

Preferably, the least squares method used in the context of the invention is a linear least squares method. As well-known from the skilled person, a regression model is a linear one when the model comprises a linear combination of the parameters, i.e.,

TO

3=1

where the function Φ, is a function of x.

Letting

¹³ Ββ₃

it can be seen that in that case the least square estimate, β is given by

The least squares method may typically be implemented using the R function ' Isf it' .

By "ridge method" is meant herein an approach in regression analysis wherein the requirement of an unbiased estimator is abandonned.

Briefly, in the case it is assumed only that X's and Y have been centered, so that there is no need for a constant term in the regression:

^■ X is a n by p matrix with centered columns,

^■ Y is a centered n-vector.

Hoerl and Kennard (1970) proposed that potential instability in the least squares estimator β = X'x Y

could be improved by adding a small constant value λ to the diagonal entries of the matrix X'X before taking its inverse. The result is the ridge regression estimator

. . — ( χ 'χ .L i t λ^{~ 1}χ'γ

Fridge \^{Λ A T AJ}p; ^{Λ 1}

Ridge regression places a particular form of constraint on the parameters (/3's): g^e is chosen to minimize the penalized sum of squares:

whi h is equivalent to minimization of subject to, for some oO,

i.e. constraining the sum of the squared coefficients.

Therefore, ridge regression puts further constraints on the parameters, /3 s, in the linear model. In this case, instead of just minimizing the residual sum of squares, a penalty term is also obtained on the /3's. This penalty term is A (a pre-chosen constant) times the squared norm of the β vector.

The ridge method may be implemented using a regularization parameter selected by the BGH procedure or by the 10-fold cross-validation.

In the context of the invention, the "10-fold cross-validation" is a general statistical method enabling selecting an estimation procedure among a family of competing procedures. Random variables Z_h Z₂,..., Z„, are observed with values in a 2 space whose joint law depends on a parameter Θ e Θ which is to be estimated. It is assumed that estimation procedures {θ_λ ,λ e Λ} are at disposal, wherein, for each parameter λ, the procedure θ_λ associates to each subset of observations Z c {Z,,..., Z_n} an estimator θ_λ (Z) of the Θ parameter. The aim of the cross-validation is to select I e Λ according to Z

Z₂,...,Z_n in such a way that the estimator λ = ^λ (z_h Z₂,..., Z_n) has a performance as close as possible to the best estimator of the family {θ_λ (Z ...,Z_n), λ e Λ}.

Given a strict and non-empty subset / of {1 ,..., n}, data are divided into two nonempty subsets, Z, = {Z„ i e 1} called validation subset and Z_/c = {Z„ i e F] called learning subset. The estimator ^{A l} = θ_λ (Z,_c) is constructed thanks to the learning sample and its performance is assessed on the validation sample by the following quantity

for a function γ : 2 χ Θ→ R well chosen.

Given a T family of groups /, the criteria of cross-validation is defined as the quantity

and the cross-validation proceedings associated to T selects ^ e Λ minimizing the criteria crit_cv.

The 10-fold cross-validation proceedings consists in taking for P an almost regular partition of {1 ,...,n} in 10 subsets of consecutive integers.

In the context of the invention, the "BGH procedure" is a procedure for selecting estimators in Gaussian regression with unknown variance, described in Baraud et al. (2012) Annates de I'lnstitut Poincare - Probabilites et Statistiques, enabling selecting the parameter λ used in the ridge method. Mainly developed to estimate the expectation f of a vector Y of n independent Gaussian variables whose variance is unknown, the BGH method is adaptable to the selection of a regularization parameter of penalization methods involving linear estimators. In the context of the study presented in Baraud et al., the method makes a selection among a family of estimators of the form F={ ^!A = Α_λ Υ, h e Λ}, where Λ c R₊. Given S a family of subspaces of ^N satisfying, for each S e S, dim (S) < n-2 and, for each ^^λ e F, a subspace of S denoted §_λ approximating ^^λ such as, in the particular case where Α_λ is symmetrical, the collection S_A (for a given λ e Λ) is engendered by the proper vectors of Α_λ

where S\ is the space engendered by the k first proper vectors of A associated to the k biggest proper values.

Given a criteria crit_a involving the error of modelling of V by n_s ^^λ (with n_s the orthogonal projection on S e S), the quality of approximation of ^^λ by Π₈ and a penalization of S via a complexity measure Δ : S→ ⁺. This criteria aims at estimating the

Ψ

quadratic risk of the Ridge estimator ^,λ and can be defined, for each λ e Λ = (s_n/2, + °°), by

(A) - ,¾∑ <»->' (ATT)' ⁺∑ W [^>

(5) where i , is the j^eme proper vector of A associated to the proper value *i^+x and, for each S e S, pen(S) is a penalization of S linked to the complexity measure Δ.

The optimal parameter of regularization λ is then selected by minimizing the above equation (5) and the Ridge estimator associated with ^^λ is controlled by a non- asymptotic boundary which resembles an oracle boundary.

In particular embodiments, the modeling step C) of the methods of the invention comprises a step (a) of homogenizing the transcriptional expression levels of the 9 cell subpopulations or of the 7 groups of cell subpopulations by:

(a1 ) withdrawing the biological samples in which the total gene transcriptional expression level is inferior to a reference value, and

(a2) normalizing the gene transcriptional expression levels in said biological samples, preferably using the Robust Multichip Averaging (RMA) method.

Preferably, in step (a1 ), the biological samples which are withdrawn are those in which the total gene expression level is statistically inferior to a reference value, typically inferior to 6 when the total gene transcriptional expression level is expressed in log2.

The normalizing step (a2) can be carried out by any technique well-known from the skilled person, such as the cyclic loess method, the contrast based method, the quantile normalization method, scaling methods such as the standard Affymetrix normalization method or a non-linear method. Such methods are for example described in Bolstad et al. (2002) Bioinformatics 19:185-193. Alternatively, the normalizing step (a2) can be carried out using the Robust Multichip Averaging (RMA) method, typically described in Irizarry et al. (2003) Biostatistics 4:249-264.

Briefly, from DNA microarrays data, such as Affymetrix DNA microarrays data, RMA is an algorithm used to create a matrix of homogenized gene expression levels. The raw intensities are then corrected from a background, transformed in log2 and normalized by the quantiles method.

- Correction of the background by the RMA method is based on the hypothesis that, given a DNA microarray, the observed intensity of the probes S is the sum of the true intensity X distributed according to an exponential law of parameter a and of a background £ of normal distribution. In particular, in order to avoid negative expression values, the normal distribution is truncated so that £ is constrained to belong to the range [0, +∞[:£ ~ Ν {μ, σ²). Under the hypothesis that is independent from £, the following model is established:

S— X ~\~ E (L.1 )

where the density of is given by:

fx (x) = ae ^aa:l[f),_+O0[ (a.-)

(L.2)

and the density of £ is given by:

Knowing the observed signal intensity S, an estimation of the true signal X can then be defined by the quantity

where m = s - μ - σ²α, Φ(.) is the distribution function associated with the normal distribution and Φ(.) is the density function associated with the normal distribution.

However, a, estimation of the true signal can be approximated by

ώ (≡)

φ i—j Φ (— )

since ^σ is neglectible and ^σ ^ is close to 1 . - Log2 transformation enables establishing a change of scale in order to facilitate the manipulation of data and to improve qualitatively the visualization of data.

- The objective of the normalization by the quantiles method is to enable to different samples of a cohorta (or subpopulation) to have the same quantiles. The quantiles method is typically disclosed in Bolstad et al. (2003) Bioinformatics 19:185.

- To calculate the expression of each gene, the RMA algorithm finally typically uses the median polish procedure, disclosed in Bolstad (2004) Low level analysis of high- density oligonucleotide array data: Background, normalization and summarization. Dissertation (Dept. of Statistics, University of California, Berkeley), which is an iterative algorithm comprising 3 steps.

For each given matrix, (a) the mediane of each line of the matrix is calculated and the mediane value of the lines is substracted thereto, (b) the mediane of each column is calculated and the mediane value of the columns is substracted, and (c) steps 1 and 2 are repeated until the nullity of all the medianes.

When the medianes of the lines and the columns are equal to 0, the algorithm converged and a so-called final matrix is obtained. By substracting this matrix to the starting matrix, a matrix of corrected value is finally obtained.

The modeling step C) of the methods of the invention uses the transcriptional expression levels of n genes among the N genes, the transcriptional expression levels of which are provided in steps A) and B).

In a particular embodiment, n and N are identical.

In another particular embodiment, 9<n<N.

Preferably, n is between 2% and 50% of N, more preferably between 2.5 and 40% of N, between 3 and 30% of N, between 3.1 and 25% of N, between 3.2 and 20% of N, between 3.3 and 19% of N, between 3.4 and 18% of N, between 3.5 and 17% of N, between 3.6 and 16% of N, between 3.7 and 15% of N, between 3.8 and 14% of N, between 3.9 and 13% of N, between 4 and 12% of N, between 4.1 and 1 1 % of N, between 4.15 and 10% of N, between 4.2 and 9% of N, between 4.25 and 8% of N, between 4.3 and 7% of N, between 4.35 and 6% of N between 4.36 and 5% of N, or 4.9, 4.8, 4.7, 4.6, 4.5, 4.4, 4.39, 4.38 or 4.37% of N.

Preferably, n is between 10 and 55000, more preferably between 50 and 54675, between 100 and 54500, between 150 and 54000, 200 and 53000, between 250 and 52000, between 300 and 51000, between 350 and 50000, between 400 and 49000, between 450 and 48000, between 500 and 47000, between 550 and 46000, between 600 and 45000, between 650 and 44000, between 700 and 43000, between 750 and 42000, between 800 and 41000, between 850 and 40000, between 900 and 39000, between 950 and 38000, between 1000 and 37000, between 1050 and 36000, between 1 100 and 35000, between 1 150 and 34000, between 1 157 and 33000, between 1200 and 32000, between 1250 and 31000, between 1300 and 30000, between 1350 and 29000, between 1400 and 28000, between 1450 and 27000, between 1500 and 26000, between 1550 and 25000, between 1600 and 24000, between 1650 and 23000, between 1667 and 22000, between 1700 and 21000, between 1750 and 20000, between 1800 and 19000, between 1850 and 18000, between 1900 and 17000, between 1950 and 16000, between 2000 and 15000, between 2050 and 14000, between 2100 and 13000, between 2150 and 12000, between 2200 and 1 1000, between 2250 and 10000, between 2300 and 9000, between 2350 and 8000, between 2389 and 7000, between 2400 and 6000, between 2450 and 5000, between 2500 and 4000, between 2550 and 3000, between 2600 and 2950, between 2650 and 2900, between 2700 and 2850 or between 2750 and 2800.

More preferably, n is comprised between 1 157 and 2521 . Most preferably, n is 2389, 2250 or 1667. In another embodiment, n is 140.

In further particular embodiments, the modeling step C) of the methods of the invention comprises a step (b) of selecting the n genes to be used among said N genes, said selecting step comprising:

(b1 ) optionally determining the median transcriptional expression level of each gene in each cell subpopulation or group of cell subpopulations to obtain a "median subject" for each cell subpopulation of group of cell subpopulations,

(b2) withdrawing control genes from the N studied genes,

(b3) withdrawing sexual genes from the N studied genes,

(b4) withdrawing the genes the expression level of which is inferior to a reference value, and

(b5) withdrawing housekeeping genes from the N studied genes;

wherein the n genes used in the modeling step are the N studied genes minus the genes withdrawn in step (b2), (b3), (b4) and (b5).

Step (b1 ) consists in determining the median transcriptional expression level of each gene in each cell subpopulation or group of cell subpopulations to obtain a "median subject" for each cell subpopulation or group of cell subpopulations.

In the context of the invention a "median subject" is a combination of the median transcriptional expression levels of each of the N genes of each cell subpopulation or group of cell subpopulations. Step (b2) corresponds to the withdrawal of control genes from the N studied genes.

By "control gene" is meant herein a gene which is used as a control in the DNA microarrays used to obtain the transcriptional expression levels Y and X®. Typically, in the DNA microarrays commercialized by Affymetrix, the probes for such control genes are identified by the prefix "AFFX-". Preferably, said N genes are the genes identified by the prefix "AFFX-" on the Platform GPL570 of the GEO Database of 7 November 2003.

Step (b3) corresponds to the withdrawal of sexual genes from the N studied genes. By "sexual gene" is meant herein a gene associated with sexual chromosomes. Typically, sexual genes includes the genes XIST, RPS4Y1 , DDX3Y, TXLNG2P, USP9Y, EIF1 AY and KDM5D

Step (b4) corresponds to the withdrawal of genes which are not expressed and which fuel the background noise, in other words the genes the expression levels of which are inferior to a reference value. As will be clearly understood by the skilled person, the reference value will depend on the normalization technique applied. In a particular embodiment, the reference value is about the mediane value of gene expression.

Typically, such genes that fuel the background noise can be identified as the genes the maximal transcriptional expression levels of which, when transformed in log2, is inferior to 6.75.

Step (b5) corresponds to the withdrawal of housekeeping genes from the N studied genes.

By "housekeeping gene" is meant herein constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. Housekeeping genes typically correspond to the genes, the transcriptional expression levels of which are the less variable between the median subjects determined in step (b1 ).

Preferably, housekeeping genes are identified, using the kmeans ++ method, as the genes, the variance of which, calculated on the 9 (or 7) "median subjects" determined at step (b1 ), is the lowest. Typically, the variance of each gene is determined on the 9 (or 7) "median subjects" obtained at step (b1 ) and the non-discriminating group is distinguished from the discriminating group using the kmeans ++ method.

The kmeans ++ algorithm can be defined as follows (given Xa set of objects which are to be grouped into k groups):

(i) Arbitrary choice of an element x from to define the first center /W, (ii) Identification of a second center M₂ associated with the element x from X justifying the biggest weight °W where ^{w ~~ 11 1 ~ x}" for each x e X

(iii) Repeting step (ii) to identify all the k centers wanted with

defines the distance betwee an element e and the closest center already established

(iv) Affectation of each element x from X to the cluster whose center M_t is the closest

(v) Calculation of the centers M_t of each cluster (barycentre) newly formed

_ 1 _T

* Card (C,.) sec,.^"

(vi) Repeating steps (iv) and (v) until all the centers do not move anymore.

In a particular embodiment, the n genes used for the modeling step C) are selected from the genes listed in Tables 1 , 2, 3, 4 and 5 below. Still preferably, the n genes used for the modeling step C) are the genes listed in Table 1 , 2, 3, 4 or 5 below.

Table 1 : List of analyzed genes Probe* Set.lD** Gene Symbol Probe* Set.lD** Gene Symbol

39 1555778 a at POSTN 76 200696 s at GSN

Probe* Set.lD** Gene Symbol 40 1555812 a at ARHGDIB 77 200749 at RAN

1 1 17 at HSPA6 41 1555852 at LOC100507463 78 200755 s at CALU

2 1405 i at CCL5 42 1555854_at AKR1 C1 /// AKR1 C2 /// 79 200765 x at CTNNA1

3 1552315 at GIMAP1 LOC100653286 80 200770 s at LAMC1

4 1552316 a at GIMAP1 43 1555962 at B3GNT7 81 200771 at LAMC1

5 1552365 at SCIN 44 1555963 x at B3GNT7 82 200826 at SNRPD2

6 1552487 a at BNC1 45 1556037 s at HHI P 83 200832 s at SCD

7 1552807 a at SIGLEC10 46 1556185 a at STEAP4 84 200838 at CTSB

8 1553043 a at CD300LF 47 1556499 s at COL1 A1 85 200839 s at CTSB

9 1553105 s at DSG2 48 1557080 s at ITGBL1 86 200872 at S100A10

10 1553132 a at TC2N 49 155741 1 s at SLC25A43 87 200877 at CCT4

1 1 1553297 a at CSF3R 50 1557636 a at C7orf57 88 200878 at EPAS1 /// LOC 100652

12 1553530 a at ITGB1 51 1557718 at PPP2R5C 89 200897 s at PALLD

13 1553613 s at FOXC1 52 15581 1 1 at MBNL1 90 200907 s at PALLD

14 1553678 a at ITGB1 53 1558397 at PECAM1 91 200923 at LGALS3BP

15 1553681 a at PRF1 54 1558508 a at C1 orf53 92 200937 s at RPL5 /// SNORD21

16 1553764 a at AJUBA 55 1558662 s at BANK1 93 200953 s at CCND2

17 1553976 a at DPCD 56 1558700 s at ZNF260 94 200965 s at ABLIM1

18 1553994 at NT5E 57 1558747 at SMCHD1 95 200972 at TSPAN3

19 1553995 a at NT5E 58 1559156 at 96 200973 s at TSPAN3

20 1554018 at GPNMB 59 1559425 at 97 200982 s at ANXA6

21 1554240 a at ITGAL 60 1559584 a at C16orf54 98 200983 x at CD59

22 1554406 a at CLEC7A 61 1563674 at FCRL2 99 200984 s at CD59

23 1554464 a at CRTAP /// LOC100653071 62 1565162 s at MGST1 100 200985 s at CD59

24 1554544 a at MBP 63 200002 at RPL35 101 200999 s at CKAP4

25 1554600 s at LMNA 64 200024 at RPS5 102 201005_at CD9 /// LOC 10065280

26 1554741_s_at FGF7 /// KGFLP1 /// 65 200036 s at RPL10A LOC100653288

KGFLP2 66 200064 at HSP90AB1 103 201008 s at TXNI P

27 1554899 s at FCER1 G 67 200089_s_at RPL4 /// SNORD16 /// 104 201009 s at TXNI P

28 1554997 a at PTGS2 SNORD18A /// SNORD18B 105 201012 at ANXA1

29 1555167 s at NAMPT /// SNORD18C 106 201013 s at PAICS

30 1555349 a at ITGB2 68 200602 at APP 107 201022 s at DSTN

31 1555355 a at ETS1 69 200606 at DSP 108 201028 s at CD99

32 1555497 a at CYP4B1 70 200636 s at PTPRF 109 201030 x at LDHB

33 1555564 a at CFI 71 200648 s at GLUL 1 10 201033 x at RPLP0

34 1555579 s at PTPRM 72 200660 at S100A1 1 1 1 1 201042 at TGM2

35 1555630 a at NARR /// RAB34 73 200665 s at LOC100505813 /// SPARC 1 12 201059 at CTTN

36 1555638 a at SAMSN1 74 200670 at XBP1 1 13 201060 x at STOM

37 1555745 a at LYZ 75 200675 at CD81 1 14 201061 s at STOM

38 1555759 a at CCL5

Probe* Set.lD** Gene Symbol Probe* Set.lD** Gene Symbol Probe* Set.lD** Gene Symbol

1 15 201063 at RCN1 153 201310 s at NREP 192 201670 s at MARCKS

1 16 201069 at MMP2 154 201324 at EMP1 193 201681 s at DLG5

1 17 201 105 at LGALS1 155 201325 s at EMP1 194 201688 s at TPD52

1 18 201 108 s at THBS1 156 201334 s at ARHGEF12 195 201689 s at TPD52

1 19 201 109 s at THBS1 157 201360 at CST3 196 201690 s at TPD52

120 201 1 10 s at THBS1 158 201387 s at UCHL1 197 201697 s at DNMT1

121 201 1 16 s at CPE 159 201416 at SOX4 198 201714 at TUBG1

122 201 1 17 s at CPE 160 201417 at SOX4 199 201720 s at LAPTM5

123 201 131 s at CDH1 161 201422 at I FI30 200 201721 s at LAPTM5

124 201 137 s at HLA-DPB1 162 201425 at ALDH2 201 201739 at SGK1

125 201 141 at GPNMB 163 201438 at COL6A3 202 201743 at CD14

126 201 147 s at TIMP3 164 201445 at CNN3 203 201744 s at LUM

127 201 149 s at TIMP3 165 201466 s at JUN 204 201785 at RNASE1

128 201 150 s at TIMP3 166 201467 s at NQ01 205 201798 s at MYOF

129 201 154_x_at RPL4 /// SNORD16 /// 167 201468 s at NQ01 206 201820 at KRT5

SNORD18A /// SNORD18B 168 201501 s at GRSF1 207 201839 s at EPCAM /// SNORD18C 169 201505 at LAMB1 208 201841 s at HSPB1

130 201 160 s at CSDA 170 201506_at LOC 100652886 /// 209 201842 s at EFEMP1

131 201 161 s at CSDA LOC100653157 /// TG FBI 210 201843 s at EFEMP1

132 201 162 at IGFBP7 171 201540 at FHL1 21 1 201848 s at BNIP3

133 201 163 s at IGFBP7 172 201560 at CLIC4 212 201849 at BNIP3

134 201 177 s at UBA2 173 201563 at SORD 213 201852 x at COL3A1

135 201 185 at HTRA1 174 201565 s at I D2 214 201858 s at SRGN

136 201212 at LGMN 175 201566 x at I D2 215 201859 at SRGN

137 201215 at PLS3 176 201578 at PODXL 216 201860 s at PLAT

138 201218 at CTBP2 177 201579 at FAT1 217 201876 at PON2

139 201242 s at ATP1 B1 178 201590 x at ANXA2 218 201884 at CEACAM5

140 201243 s at ATP1 B1 179 201596 x at KRT18 219 201887 at IL13RA1

141 201261 x at BGN 180 201616 s at CALD1 220 201888 s at IL13RA1

142 201268 at NME1 -NME2 /// NME2 181 201617 x at CALD1 221 201889 at FAM3C

143 201278 at DAB2 182 201631 s at I ER3 222 201890 at RRM2

144 201279 s at DAB2 183 201641 at BST2 223 201893 x at DCN

145 201280 s at DAB2 184 201645 at TNC 224 201923 at PRDX4

146 201288 at ARHGDIB 185 201650 at KRT19 225 201938 at CDK2AP1

147 201289 at CYR61 186 201653 at CNIH 226 201939 at PLK2

148 201291 s at TOP2A 187 201656 at ITGA6 227 201946 s at CCT2

149 201292 at TOP2A 188 201659 s at ARL1 228 201951 at ALCAM

150 201300 s at PRNP 189 201666 at TIMP1 229 201952 at ALCAM

151 201307 at SEPT1 1 190 201667 at GJA1 230 201963 at ACSL1

152 201309 x at NREP 191 201669 s at MARCKS 231 201976 s at MYO10

232 201983 s at EGFR 272 20231 1 s at COL1 A1 312 202619 s at PLOD2

233 201995 at EXT1 273 202314 at CYP51 A1 /// LRRD1 313 202620 s at PLOD2

234 201998 at ST6GAL1 274 202336 s at PAM 314 202625 at LYN

235 202007 at NID1 275 202341 s at TRIM2 315 202626 s at LYN

236 20201 1 at TJP1 276 202342 s at TRIM2 316 202627 s at SERPINE1

237 202016 at MEST 277 202345 s at FABP5 317 202628 s at SERPINE1

238 202018 s at LTF 278 202350 s at LOC100506558 /// MATN2 318 202663 at WIPF1

239 202037 s at SFRP1 279 202351 at ITGAV 319 202664 at WIPF1

240 202052 s at RAI14 280 202357 s at CFB 320 202668 at EFNB2

241 202068 s at LDLR 281 202363 at SPOCK1 321 202672 s at ATF3

242 202071 at SDC4 282 202371 at TCEAL4 322 202686 s at AXL

243 202073 at OPTN 283 202375 at SEC24D 323 202687 s at TNFSF10

244 202074 s at OPTN 284 202381 at ADAM9 324 202688 at TNFSF10

245 202083 s at SEC14L1 285 202388 at RGS2 325 202718 at IGFBP2

246 202085 at TJP2 286 202391 at BASP1 326 202729 s at LTBP1

247 202086 at MX1 287 202403 s at COL1 A2 327 202732 at PKIG

248 202087 s at CTSL1 288 202404 s at COL1 A2 328 202733 at P4HA2

249 2021 12 at VWF 289 20241 1 at I FI27 329 202741 at PRKACB

250 202132 at WWTR1 290 202431 s at MYC 330 202743 at PIK3R3

251 202133 at WWTR1 291 202435 s at CYP1 B1 331 202746 at ITM2A

252 202156 s at CELF2 292 202436 s at CYP1 B1 332 202747 s at ITM2A

253 202157 s at CELF2 293 202437 s at CYP1 B1 333 202748 at GBP2

254 202196 s at DKK3 294 202454 s at ERBB3 334 202759 s at AKAP2 /// PALM2-AKA

255 202202 s at LAMA4 295 202458 at PRSS23 335 202760 s at AKAP2 /// PALM2-AKA

256 202206 at ARL4C 296 202468 s at CTNNAL1 336 202761 s at SYNE2

257 202207 at ARL4C 297 202478 at TRIB2 337 202765 s at FBN1

258 202232 s at EIF3M 298 202481 at DHRS3 338 202766 s at FBN1

259 202237 at NNMT 299 202489 s at FXYD3 339 202786 at STK39

260 202241 at TRIB1 300 202499 s at SLC2A3 340 202796 at SYNPO

261 202252 at RAB13 301 202503 s at KIAA0101 341 202803 s at ITGB2

262 202260 s at STXBP1 302 202504 at TRIM29 342 202806 at DBN1

263 202269 x at GBP1 303 202510 s at TNFAIP2 343 202820 at AHR

264 202270 at GBP1 304 202524 s at SPOCK2 344 202833 s at SERPINA1

265 202283 at SERPINF1 305 202546 at VAMP8 345 202859 x at IL8

266 202284 s at CDKN1 A 306 202551 s at CRIM1 346 202869 at OAS1

267 202286 s at TACSTD2 307 202552 s at CRIM1 347 202877 s at CD93

268 202289 s at TACC2 308 202554 s at GSTM3 348 202878 s at CD93

269 202291 s at MGP 309 202581 at HSPA1 A /// HSPA1 B 349 202888 s at ANPEP

270 202295 s at CTSH 310 202589 at TYMS 350 202897 at SIRPA

271 202310 s at COL1 A1 31 1 202609 at EPS8 351 202900 s at NUP88

352 202901 x at CTSS 392 203180 at ALDH1 A3 431 203510 at MET

353 202902 s at CTSS 393 203184 at FBN2 432 203528 at SEMA4D

354 202910 s at CD97 394 203185 at RASSF2 433 203535 at S100A9

355 202912 at ADM 395 203186 s at S100A4 434 203543 s at KLF9

356 202917 s at S100A8 396 203196 at ABCC4 435 203560 at GGH

357 202931 x at BIN1 397 20321 1 s at MTMR2 436 203561 at FCGR2A

358 202932 at YES1 398 203213 at CDK1 437 203562 at FEZ1

359 202933 s at YES1 399 203216 s at MY06 438 203570 at LOXL1

360 202934 at HK2 400 203243 s at PDLIM5 439 203571 s at C10orf1 16

361 202935 s at SOX9 401 203259 s at HDDC2 440 203574 at NFIL3

362 202946 s at BTBD3 402 203290 at HLA-DQA1 441 203591 s at CSF3R

363 202948 at IL1 R1 403 203305 at F13A1 442 203603 s at ZEB2

364 202949 s at FHL2 404 203323 at CAV2 443 203608 at ALDH5A1

365 202957 at HCLS1 405 203324 s at CAV2 444 203636 at MI DI

366 202971 s at DYRK2 406 203325 s at COL5A1 445 203637 s at MI DI

367 202975 s at RHOBTB3 407 203355 s at PSD3 446 203642 s at COBLL1

368 202976 s at RHOBTB3 408 203362 s at MAD2L1 447 203645 s at CD163

369 202990 at PYGL 409 203372 s at SOCS2 448 203650 at PROCR

370 202998 s at LOXL2 410 203386 at TBC1 D4 449 203685 at BCL2

371 203002 at AMOTL2 41 1 203387 s at TBC1 D4 450 203691 at PI3

372 203021 at SLPI 412 203394 s at HES1 451 203695 s at DFNA5

373 203037 s at MTSS1 413 203395 s at HES1 452 203708 at PDE4B

374 203038 at PTPRK 414 203401 at PRPS2 453 203725 at GADD45A

375 203041 s at LAMP2 415 203404 at ARMCX2 454 203735 x at PPFIBP1

376 203042 at LAMP2 416 203413_at LOC100653018 /// 455 203753 at TCF4

377 203048 s at TTC37 LOC100653255 /// NELL2 456 203757 s at CEACAM6

378 203049 s at TTC37 417 203416 at CD53 457 203760 s at SLA

379 203058 s at PAPSS2 418 203424 s at IGFBP5 458 203761 at SLA

380 203060 s at PAPSS2 419 203434 s at MME 459 203765 at GCA

381 203065 s at CAV1 420 203435 s at MME 460 203767 s at STS

382 203066 at CHST15 421 203440 at CDH2 461 203774 at MTR

383 203083 at THBS2 422 203470 s at PLEK 462 203780 at MPZL2

384 203088 at FBLN5 423 203471 s at PLEK 463 203789 s at SEMA3C

385 203108 at GPRC5A 424 203474 at IQGAP2 464 203799 at CD302 /// LY75-CD302

386 203126 at IMPA2 425 203476 at TPBG 465 203810 at DNAJB4

387 203131 at PDGFRA 426 203485 at RTN1 466 203820 s at IGF2BP3

388 203139 at DAPK1 427 203499 at EPHA2 467 203827 at WIPI1

389 203148 s at TRIM14 428 203504 s at ABCA1 468 203828 s at IL32

390 203153 at IFIT1 429 203508 at TNFRSF1 B 469 203851 at IGFBP6

391 203167 at TIMP2 430 203509 at SORL1 470 203854 at CFI

471 203857 s at PDIA5 51 1 2041 14 at NI D2 551 204415 at IFI6

472 203874 s at SMARCA1 512 2041 15 at GNG1 1 552 204439 at IFI44L

473 203875 at SMARCA1 513 2041 18 at CD48 553 204446 s at ALOX5

474 203879 at PIK3CD 514 204122 at TYROBP 554 204455 at DST /// LOC 100652766

475 203881 s at DMD 515 204135 at FILIP1 L 555 204466 s at SNCA

476 203887 s at THBD 516 204141 at TUBB2A 556 204469 at PTPRZ1

477 203892 at WFDC2 517 204151 x at AKR1 C1 557 204470 at CXCL1

478 203908 at SLC4A4 518 204153 s at MFNG 558 204472 at GEM

479 203910 at ARHGAP29 519 204173 at MYL6B 559 204475 at MMP1

480 203922 s at CYBB 520 204174 at ALOX5AP 560 204502 at SAMHD1

481 203923 s at CYBB 521 204187 at GMPR 561 204517 at PPIC

482 203925 at GCLM 522 204192 at CD37 562 204518 s at PPIC

483 203932 at HLA-DMB 523 204197 s at RUNX3 563 204529 s at TOX

484 203935 at ACVR1 524 204198 s at RUNX3 564 204533 at CXCL10

485 203939 at NT5E 525 204201 s at PTPN13 565 204563 at SELL

486 203971 at SLC31 A1 526 204204 at SLC31 A2 566 204570 at COX7A1

487 203973 s at CEBPD 527 204220 at GMFG 567 204588 s at SLC7A7

488 203987 at FZD6 528 204224 s at GCH1 568 204595 s at STC1

489 203989 x at F2R 529 204232 at FCER1 G 569 204597 x at STC1

490 204004 at PAWR 530 204235 s at GULP1 570 204602 at DKK1

491 204005 s at PAWR 531 204236 at FLU 571 204612 at PKIA

492 204006 s at FCGR3A /// FCGR3B 532 204237 at GULP1 572 204614 at SERPINB2

493 204007 at FCGR3B 533 204249 s at LM02 573 204619 s at VCAN

494 20401 1 at SPRY2 534 204256 at ELOVL6 574 204620 s at VCAN

495 204014 at DUSP4 535 204268 at S100A2 575 204655 at CCL5

496 204017 at KDELR3 536 204273 at EDNRB 576 204661 at CD52

497 204030 s at IQCJ-SCHIP1 /// SCHIP1 537 204298 s at LOX 577 204670_x_at HLA-DRB1 /// HLA-D

498 204032 at BCAR3 538 204304 s at PROM1 /// LOC 100507709

499 204036 at LPAR1 539 204319 s at RGS10 LOC100507714

500 204042 at WASF3 540 204331 s at MRPS12 578 204674 at LRMP

501 204048 s at PHACTR2 541 204337 at RGS4 579 204677 at CDH5

502 204057 at IRF8 542 204351 at S100P 580 204681 s at RAPGEF5

503 204058 at ME1 543 204352 at TRAF5 581 204682 at LTBP2

504 204059 s at ME1 544 204359 at FLRT2 /// LOC100506718 582 204683 at ICAM2

505 204066 s at AGAP1 545 204363 at F3 583 204686 at IRS1

506 204070 at RARRES3 546 204379 s at FGFR3 584 204688 at SGCE

507 204072 s at FRY 547 204393 s at ACPP 585 204689 at HHEX

508 204083 s at TPM2 548 204400 at EFS 586 204698 at ISG20

509 204103 at CCL4 549 204405 x at DIMT1 587 204702 s at NFE2L3

510 2041 12 s at HNMT 550 20441 1 at KI F21 B 588 204714 s at F5

589 204719 at ABCA8 629 205005 s at NMT2 668 205381 at LRRC17

590 204731 at TGFBR3 630 205006 s at NMT2 669 205382 s at CFD

591 204734 at KRT15 631 205039 s at IKZF1 670 205403 at IL1 R2

592 204744 s at IARS 632 205044 at GABRP 671 205406 s at SPA17

593 204747 at IFIT3 633 205049 s at CD79A 672 205407 at RECK

594 204748 at PTGS2 634 205064 at SPRR1 B 673 205419 at GPR183

595 204750 s at DSC2 635 205081 at CRI P1 674 205422 s at ITGBL1

596 204751 x at DSC2 636 205098 at CCR1 675 205466 s at HS3ST1

597 204759 at RCBTB2 637 205099 s at CCR1 676 205476 at CCL20

598 204774 at EVI2A 638 205101 at CI ITA 677 205479 s at PLAU

599 204777 s at MAL 639 2051 14_s_at CCL3 /// CCL3L1 /// 678 205488 at GZMA

600 204779 s at HOXB7 CCL3L3 679 205495 s at GNLY

601 204790 at SMAD7 640 2051 19 s at FPR1 680 205499 at SRPX2

602 204794 at DUSP2 641 205120 s at SGCB 681 205513 at TCN1

603 204797 s at EML1 642 205128 x at PTGS1 682 205532 s at CDH6

604 204823 at NAV3 643 205133 s at HSPE1 683 205542 at STEAP1

605 204825 at MELK 644 205147 x at NCF4 684 205547 s at TAGLN

606 204834 at FGL2 645 205157 s at JUP /// KRT17 685 205552 s at OAS1

607 204839 at POP5 646 205159 at CSF2RB 686 205568 at AQP9

608 204846 at CP 647 205171 at PTPN4 687 205569 at LAMP3

609 204855 at SERPINB5 648 205174 s at QPCT 688 205573 s at SNX7

610 204860 s at LOC 100509323 /// NAI P 649 205180 s at ADAM8 689 205590 at RASGRP1

61 1 204882 at ARHGAP25 650 205185 at SPINK5 690 205597 at SLC44A4

612 204890 s at LCK 651 205194 at PSPH 691 205609 at ANGPT1

613 204891 s at LCK 652 205207 at IL6 692 205618 at PRRG1

614 204912 at IL10RA 653 205220 at HCAR3 693 205627 at CDA

615 204923 at SASH3 654 205234 at SLC16A4 694 205639 at AOAH

616 204924 at TLR2 655 205237 at FCN1 695 205668 at LY75

617 204932 at TNFRSF1 1 B 656 205239 at AREG /// AREGB 696 205671 s at HLA-DOB

618 204933 s at TNFRSF1 1 B 657 205267 at POU2AF1 697 205680 at MMP10

619 204949 at ICAM3 658 205269 at LCP2 698 205681 at BCL2A1

620 204951 at RHOH 659 205270 s at LCP2 699 205709 s at CDS1

621 204955 at SRPX 660 205280 at GLRB 700 205715 at BST1

622 204959 at MNDA 661 205285 s at FYB 701 205725 at SCGB1 A1

623 204960 at PTPRCAP 662 205289 at BMP2 702 205758 at CD8A

624 204961 s at NCF1 /// NCF1 B /// NCF1 C 663 205290 s at BMP2 703 205767 at EREG

625 204971 at CSTA 664 205291 at IL2RB 704 205786 s at ITGAM

626 204992 s at PFN2 665 205306 x at KMO 705 205790 at SKAP1

627 204994 at MX2 666 205316 at SLC15A2 706 205798 at IL7R

628 205003 at DOCK4 667 205319 at PSCA 707 205804 s at TRAF3I P3

708 205821 at KLRC4-KLRK1 /// KLRK1 748 206366 x at XCL1 788 2071 1 1 at EMR1

709 205828 at MMP3 749 206382 s at BDNF 789 207173 x at CDH1 1

710 205831 at CD2 750 206385 s at ANK3 790 207224 s at SIGLEC7

71 1 205844 at VNN1 751 206392 s at RARRES1 791 207238 s at PTPRC

712 205859 at LY86 752 206398 s at CD19 792 207265 s at KDELR3

713 205863 at S100A12 753 206414 s at ASAP2 793 207275 s at ACSL1

714 205883 at ZBTB16 754 206420 at IGSF6 794 207339 s at LTB

715 205896 at SLC22A4 755 206432 at HAS2 795 207387 s at GK

716 205898 at CX3CR1 756 206438 x at TCTN2 796 207419 s at RAC2

717 205899 at CCNA1 757 206464 at BMX 797 207430 s at MSMB

718 205922 at VNN2 758 206481 s at LDB2 798 207469 s at PIR

719 205936 s at HK3 759 206488 s at CD36 799 207480 s at MEIS2

720 205945 at IL6R 760 206513 at AIM2 800 207509 s at LAIR2

721 205979 at SCGB2A1 761 206515 at CYP4F3 801 207522 s at ATP2A3

722 205990 s at WNT5A 762 206561 s at AKR1 B10 802 207540 s at SYK

723 205997 at ADAM28 763 206584 at LY96 803 207571 x at C1 orf38

724 206025 s at TNFAI P6 764 206631 at PTGER2 804 207610 s at EMR2

725 206026 s at TNFAI P6 765 206632 s at APOBEC3B 805 207651 at GPR171

726 206059 at ZNF91 766 206637 at P2RY14 806 207655 s at BLNK

727 206060 s at PTPN22 767 206638 at HTR2B 807 207677 s at NCF4

728 206082 at HCP5 768 206643 at HAL 808 207697 x at LILRB2

729 206099 at PRKCH 769 206666 at GZMK 809 207738 s at NCKAP1

730 2061 1 1 at RNASE2 770 206687 s at PTPN6 810 207761 s at METTL7A

731 2061 16 s at TPM1 771 206702 at TEK 81 1 207777 s at SP140

732 206150 at CD27 772 206707 x at FAM65B 812 207795 s at KLRD1

733 206157 at PTX3 773 206710 s at EPB41 L3 813 207812 s at GORASP2

734 206165 s at CLCA2 774 206761 at CD96 814 207826 s at ID3

735 206166 s at CLCA2 775 206765 at KCNJ2 815 207847 s at MUC1

736 206172 at IL13RA2 776 206785 s at KLRC1 /// KLRC2 816 207850 at CXCL3

737 206176 at BMP6 777 206804 at CD3G 817 207857 at LILRA2

738 206197 at NME5 778 206805 at S EM A3 A 818 207935 s at KRT13

739 206207 at CLC 779 206884 s at SCEL 819 207957 s at PRKCB

740 206271 at TLR3 780 206914 at CRTAM 820 208018 s at HCK

741 206307 s at FOXD1 781 206924 at IL1 1 821 208025 s at HMGA2

742 206323 x at OPHN1 782 206953 s at LPHN2 822 208029 s at LAPTM4B

743 206332 s at IFI 16 783 206978 at CCR2 823 208146 s at CPVL

744 206336 at CXCL6 784 207008 at CXCR2 824 208158 s at OSBPL1 A

745 206337 at CCR7 785 207030 s at CSRP2 825 208190 s at LSR

746 206343 s at NRG1 786 207072 at IL18RAP 826 208306_x_at HLA-DRB1

747 206363 at MAF 787 207085 x at CSF2RA LOC 100507709

LOC100507714 863 208966 x at I FI16 903 209290 s at NFIB

827 208407_s_at CTNND1 /// TMX2- 864 208981 at PECAM1 904 209291 at ID4

CTNND1 865 208982 at PECAM1 905 209298 s at ITSN1

828 208438 s at FGR 866 208983 s at PECAM1 906 209303 at NDUFS4

829 208450 at LGALS2 867 208998 at UCP2 907 209306 s at SWAP70

830 208607_s_at SAA1 /// SAA2 /// SAA2- 868 209016 s at KRT7 908 209312_x_at HLA-DRB1 /// HLA-D

SAA4 869 209070 s at RGS5 /// HLA-DRB5

831 208636 at ACTN1 870 209071 s at RGS5 LOC 100507709

832 208650 s at CD24 871 209083 at COR01 A LOC100507714

833 208651 x at CD24 872 209094 at DDAH1 909 209335 at DCN

834 208662 s at TTC3 /// TTC3P1 873 209099 x at JAG1 910 209340 at UAP1

835 208680 at PRDX1 874 209101 at CTGF 91 1 209348 s at MAF

836 208683 at CAPN2 875 209108 at TSPAN6 912 209351 at KRT14

837 208690 s at PDLIM1 876 209109 s at TSPAN6 913 209355 s at PPAP2B

838 20871 1 s at CCND1 877 2091 14 at TSPAN1 914 209369 at ANXA3

839 208712 at CCND1 878 209120 at NR2F2 915 209373 at MALL

840 208747 s at C1 S 879 209121 x at NR2F2 916 209374 s at IGHM

841 208768 x at RPL22 880 209125 at KRT6A 917 209377 s at HMGN3

842 208782 at FSTL1 881 209129 at TRIP6 918 209386 at TM4SF1

843 208789 at PTRF 882 209135 at ASPH 919 209387 s at TM4SF1

844 208791 at CLU 883 209138 x at IGLC1 920 209395 at CHI3L1

845 208792 s at CLU 884 209146 at MSM01 921 209396 s at CHI3L1

846 208798 x at GOLGA8A 885 209160 at AKR1 C3 922 209406 at BAG2

847 208818 s at COMT 886 209173 at AGR2 923 209447 at SYNE1

848 208820_at LOC 100653024 /// 887 209189 at FOS 924 209480 at HLA-DQB1

LOC100653146 /// PTK2 888 209191 at TUBB6 925 209485 s at OSBPL1 A

849 208836 at ATP1 B3 889 209198 s at SYT1 1 926 209487 at RBPMS

850 208843 s at GORASP2 890 209199 s at MEF2C 927 209488 s at RBPMS

851 208856 x at RPLPO 891 209200 at MEF2C 928 209498 at CEACAM1

852 208885 at LCP1 892 209201 x at CXCR4 929 209505 at NR2F1

853 208886 at H1 F0 893 209209 s at FERMT2 930 209529 at PPAP2C

854 208890 s at PLXNB2 894 209210 s at FERMT2 931 209539 at ARHGEF6

855 208891 at DUSP6 895 20921 1 at KLF5 932 209550 at NDN

856 208892 s at DUSP6 896 209212 s at KLF5 933 209555 s at CD36

857 208894 at HLA-DRA 897 209218 at SQLE 934 209576 at GNAI1

858 208910 s at C1 QBP 898 209228 x at TUSC3 935 209581 at PLA2G16

859 208923 at CYFI P1 899 209230 s at NUPR1 936 209582 s at CD200

860 208937 s at ID1 900 209277 at TFPI2 937 209583 s at CD200

861 208949 s at LGALS3 901 209278 s at TFPI2 938 209604 s at GATA3

862 208965 s at IFI 16 902 209289 at NFIB 939 209606 at CYTI P

940 209609 s at MRPL9 976 209946 at VEGFC 1015 210473 s at GPR125

941 209619 at CD74 977 209949 at NCF2 1016 210479 s at RORA

942 209651 at TGFB1 I 1 978 209955 s at FAP 1017 210495 x at FN1

943 209655 s at TMEM47 979 209960 at HGF 1018 21051 1 s at INHBA

944 209656 s at TMEM47 980 209990 s at GABBR2 1019 210512 s at VEGFA

945 209670 at TRAC 981 210002 at GATA6 1020 210517 s at AKAP12

946 209671 x at TRAC 982 210026 s at CARD10 1021 210519 s at NQ01

947 209684 at RIN2 983 210027 s at APEX1 1022 210538 s at BIRC3

948 209685 s at PRKCB 984 210029 at I D01 1023 210606 x at KLRD1

949 209699_x_at AKR1 C2 /// 985 210031 at CD247 1024 210609 s at TP53I3

LOC100653286 986 210038 at PRKCQ 1025 210629 x at LST1

950 209717 at EVI5 987 210064 s at UPK1 B 1026 210645 s at TTC3 /// TTC3P1

951 209719 x at SERPINB3 988 210065 s at UPK1 B 1027 210663 s at KYNU

952 209720 s at SERPINB3 989 210089 s at LAMA4 1028 210664 s at TFPI

953 209728_at HLA-DRB4 /// 990 210095 s at IGFBP3 1029 210665 at TFPI

LOC100509582 991 210096 at CYP4B1 1030 210715 s at SPINT2

954 209765 at ADAM19 992 210105 s at FYN 1031 210754 s at LYN

955 209771 x at CD24 993 2101 19 at KCNJ15 1032 210757 x at DAB2

956 209772 s at CD24 994 210136 at MBP 1033 210762 s at DLC1

957 209774 x at CXCL2 995 210139 s at PMP22 1034 210764 s at CYR61

958 209791 at PADI2 996 210140 at CST7 1035 210772 at FPR2

959 209792 s at KLK10 997 210145 at PLA2G4A 1036 210785 s at C1 orf38

960 209795 at CD69 998 210163 at CXCL1 1 1037 210809 s at POSTN

961 209803 s at PHLDA2 999 210164 at GZMB 1038 210827 s at ELF3

962 209813 x at TARP 1000 210172 at SF1 1039 210830 s at PON2

963 209821 at IL33 1001 210176 at TLR1 1040 210844 x at CTNNA1

964 209823_x_at HLA-DQB1 /// 1002 210184 at ITGAX 1041 210845 s at PLAUR

LOC100293977 1003 210283 x at PAI P1 1042 210847 x at TNFRSF25

965 209827 s at IL16 1004 210297 s at MSMB 1043 210869 s at MCAM

966 209829 at FAM65B 1005 210299 s at FHL1 1044 210873 x at APOBEC3A

967 209861 s at METAP2 1006 210321 at GZMH 1045 210889 s at FCGR2B

968 209879 at SELPLG 1007 210347 s at BCL1 1 A 1046 210895 s at CD86

969 209881 s at LAT 1008 210356 x at MS4A1 1047 210896 s at ASPH

970 209890 at TSPAN5 1009 210413 x at SERPINB3 /// SERPINB4 1048 210904 s at IL13RA1

971 209900 s at SLC16A1 1010 210423 s at SLC1 1 A1 1049 210915 x at TRBC1

972 209901 x at AIF1 101 1 210425_x_at GOLGA8A /// GOLGA8B /// 1050 210970 s at IBTK

973 209905_at HOXA10-HOXA9 /// LOC100508892 1051 210972_x_at TRAC /// TRAJ17

HOXA9 1012 210426 x at RORA TRAV20

974 209921 at SLC7A1 1 1013 210427 x at ANXA2 1052 210982 s at HLA-DRA

975 209933 s at CD300A 1014 210448 s at P2RX5 1053 210986 s at TPM1

1054 210987 x at TPM1 1090 211668 s at PLAU 1128 212070 at GPR56

1055 210992 x at FCGR2C 1091 211675 s at MDFIC 1129 212074 at SUN1

1056 210993 s at SMAD1 1092 211684 s at DYNC1I2 1130 212077 at CALD1

1057 211005 at LAT 1093 211710_x_at RPL4 /// SNORD16 /// 1131 212085 at SLC25A6

1058 211071 s at MLLT11 SNORD18A /// SNORD18B 1132 212095 s at MTUS1

1059 211122 s at CXCL11 /// SNORD18C 1133 212096 s at MTUS1

1060 211138 s at KMO 1094 211719 x at FN1 1134 212097 at CAV1

1061 211144 x at TARP /// TRGC2 1095 211720 x at RPLPO 1135 212104 s at RBFOX2

1062 211161 s at COL3A1 1096 211734 s at FCER1A 1136 212136 at ATP2B4

1063 211163 s at TNFRSF10C 1097 211737 x at LOC 100287705/// PTN 1137 212143 s at IGFBP3

1064 211178 s at PSTPIP1 1098 211742 s at EVI2B 1138 212148 at PBX1

1065 211339 s at ITK 1099 211747 s at LSM5 1139 212158 at SDC2

1066 211340 s at MCAM 1100 211776 s at EPB41L3 1140 212169 at FKBP9

1067 211343 s at COL13A1 1101 211794 at FYB 1141 212188 at KCTD12

1068 211372 s at IL1R2 1102 211795 s at FYB 1142 212190 at SERPINE2

1069 211395 x at FCGR2C 1103 211796 s at TRBC1 1143 212192 at KCTD12

1070 211423 s at SC5DL 1104 211813 x at DCN 1144 212195 at IL6ST

1071 211429 s at SERPINA1 1105 211828 s at TNIK 1145 212224 at ALDH1A1

1072 211430_s_at IGHG1 /// IGHG2 /// IGHM 1106 211864 s at MYOF 1146 212226 s at PPAP2B

/// IGHV4-31 1107 211896 s at DCN 1147 212230 at PPAP2B

1073 211458_s_at GABARAPL1 /// 1108 211902 x at YME1L1 1148 212233 at MAPI B

GABARAPL3 1109 211906 s at SERPINB4 1149 212254 s at DST/// LOC 100652766

1074 211506 s at IL8 1110 211919 s at CXCR4 1150 212298 at NRP1

1075 211538 s at HSPA2 1111 211924 s at PLAUR 1151 212314 at SEL1L3

1076 211564 s at PDLIM4 1112 211945 s at ITGB1 1152 212333 at FAM98A

1077 211571 s at VCAN 1113 211953 s at IP05 1153 212338 at MY01D

1078 211581 x at LST1 1114 211959 at IGFBP5 1154 212344 at SULF1

1079 211582 x at LST1 1115 211962 s at ZFP36L1 1155 212353 at SULF1

1080 211597 s at HOPX 1116 211964 at COL4A2 1156 212354 at SULF1

1081 211612 s at IL13RA1 1117 211971 s at LRPPRC 1157 212364 at MY01B

1082 211623 s at FBL 1118 211972 x at RPLPO 1158 212372 at MYH10

1083 211645 x at 1119 211980 at COL4A1 1159 212386 at TCF4

1084 211651 s at LAMB1 1120 211981 at COL4A1 1160 212397 at RDX

1085 211653_x_at AKR1C2 /// 1121 211990 at HLA-DPA1 1161 212413 at SEPT6

LOC100653286 1122 211991 s at HLA-DPA1 1162 212414 s at GLYR1 /// SEPT6

1086 211654 x at HLA-DQB1 1123 212012 at PXDN 1163 212415 at SEPT6

1087 211656_x_at HLA-DQB1 /// 1124 212013 at PXDN 1164 212460 at SPTSSA

LOC100293977 1125 212018 s at RSL1D1 1165 212464 s at FN1

1088 211657 at CEACAM6 1126 212062 at ATP9A 1166 212473 s at MICAL2

1089 211661 x at PTAFR 1127 212067 s at C1R 1167 212486 s at FYN

1 168 212488 at COL5A1 1206 212992 at AHNAK2 1245 213423 x at TUSC3

1 169 212489 at COL5A1 1207 212998_x_at HLA-DQB1 /// 1246 213425 at WNT5A

1 170 212509 s at MXRA7 LOC100293977 1247 213428 s at COL6A1

1 171 212531 at LCN2 1208 213002 at MARCKS 1248 213429 at BICC1

1 172 212538 at DOCK9 1209 213005 s at KANK1 1249 213455 at FAM1 14A1

1 173 212560 at SORL1 1210 213006 at CEBPD 1250 213475 s at ITGAL

1 174 212587 s at PTPRC 121 1 213010 at PRKCDBP 1251 213503 x at ANXA2

1 175 212588 at PTPRC 1212 213029 at NFIB 1252 213506 at F2RL1

1 176 212589 at RRAS2 1213 213032 at NFIB 1253 213524 s at G0S2

1 177 212590 at RRAS2 1214 213036 x at ATP2A3 1254 213534 s at PASK

1 178 212592 at IGJ 1215 213056 at FRMD4B 1255 213537 at HLA-DPA1

1 179 212599 at AUTS2 1216 213080 x at RPL5 /// SNORD21 1256 213539 at CD3D

1 180 212606 at WDFY3 1217 213093 at PRKCA 1257 213541 s at ERG

1 181 212614 at ARID5B 1218 213094 at GPR126 1258 213552 at GLCE

1 182 212636 at QKI 1219 213095 x at AI F1 1259 213564 x at LDHB

1 183 212657 s at IL1 RN 1220 213106 at ATP8A1 1260 213566 at RNASE6

1 184 212667 at LOC100505813 /// SPARC 1221 2131 10 s at COL4A5 1261 213578 at BMPR1 A

1 185 212671_s_at HLA-DQA1 /// HLA-DQA2 1222 213135 at TIAM1 1262 213618 at ARAP2

/// LOC100507718 /// 1223 213139 at SNAI2 1263 213620 s at ICAM2 LOC100509457 1224 213142 x at PION 1264 213624 at SMPDL3A

1 186 212681 at EPB41 L3 1225 213160 at DOCK2 1265 213664 at SLC1 A1

1 187 212690 at DDHD2 1226 213170 at GPX7 1266 213668 s at SOX4

1 188 212698 s at SEPT10 1227 213193 x at TRBC1 1267 213674 x at IGHD

1 189 212706 at RASA4 /// RASA4B 1228 213194 at ROB01 1268 213680 at KRT6B

1 190 212724 at RND3 1229 213240 s at KRT4 1269 213693 s at MUC1

1 191 212750 at PPP1 R16B 1230 213241 at PLXNC1 1270 213725 x at XYLT1

1 192 212761 at TCF7L2 1231 213249 at FBXL7 1271 213733 at MY01 F

1 193 212764 at ZEB1 1232 213258 at TFPI 1272 213766 x at GNA1 1

1 194 212820 at DMXL2 1233 213262 at SACS 1273 213791 at PENK

1 195 212826 s at SLC25A6 1234 213309 at PLCL2 1274 213796 at SPRR1 A

1 196 212827 at IGHM 1235 213325 at PVRL3 1275 213797 at RSAD2

1 197 212843 at NCAM1 1236 213338 at TMEM158 1276 213800 at CFH

1 198 212846 at RRP1 B 1237 213342 at YAP1 1277 213802 at PRSS12

1 199 212873 at HMHA1 1238 213355 at ST3GAL6 1278 213817 at IRAK3

1200 212912 at RPS6KA2 1239 213375 s at N4BP2L1 1279 213830 at YME1 L1

1201 212942 s at KIAA1 199 1240 213377 x at RPS12 1280 213831_at HLA-DQA1

1202 212956 at TBC1 D9 1241 213392 at IQCK LOC100507718

1203 212958 x at PAM 1242 213397 x at RNASE4 LOC100509457

1204 212977 at CXCR7 1243 213416 at ITGA4 1281 213844 at HOXA5

1205 212985 at APBB2 1244 213418 at HSPA6 1282 213865 at DCBLD2

1283 213888 s at TRAF3I P3 1320 214574 x at LST1 1355 215806 x at TARP /// TRGC2

1284 213891 s at TCF4 1321 214581 x at TNFRSF21 1356 215813 s at PTGS1

1285 213901 x at RBFOX2 1322 214617 at PRF1 1357 215925 s at CD72

1286 213905 x at BGN 1323 214620 x at PAM 1358 215933 s at HHEX

1287 213906 at MYBL1 1324 214651_s_at HOXA10-HOXA9 /// 1359 216033 s at FYN

1288 213915 at NKG7 HOXA9 /// MI R196B 1360 216268 s at JAG1

1289 213931 at ID2 /// ID2B 1325 214669 x at IGKC 1361 216379 x at CD24

1290 213947 s at NUP210 1326 214677 x at IGLC1 1362 216442 x at FN1

1291 213975 s at LYZ 1327 214724 at DIXDC1 1363 216598 s at CCL2

1292 213998 s at DDX17 1328 214735 at I PCEF1 1364 216834 at RGS1

1293 214032 at ZAP70 1329 214953 s at APP 1365 216841 s at LOC100129518 /// SO

1294 214039 s at LAPTM4B 1330 214974 x at CXCL5 1366 216905 s at ST14

1295 214042 s at RPL22 1331 215016 x at DST /// LOC 100652766 1367 216920 s at TARP /// TRGC2

1296 214084 x at NCF1 C 1332 215017 s at FNBP1 L 1368 216950_s_at FCGR1 A /// FCGR1

1297 214146 s at PPBP 1333 215034 s at TM4SF1 FCGR1 C

1298 214167 s at RPLPO 1334 215049 x at CD163 1369 216973 s at HOXB7

1299 214181 x at LST1 1335 215051 x at AI F1 1370 217022 s at IGH@ /// IGHA1 /// IGH

1300 214183 s at TKTL1 1336 215071 s at HIST1 H2AC 1371 217028 at CXCR4

1301 214214 s at C1 QBP 1337 215073 s at NR2F2 1372 217078 s at CD300A

1302 214240 at GAL 1338 215076 s at COL3A1 1373 217109 at MUC4

1303 214247 s at DKK3 1339 215101 s at CXCL5 1374 217143 s at YME1 L1

1304 214321 at NOV 1340 2151 1 1 s at TSC22D1 1375 217202 s at GLUL

1305 214329 x at TNFSF10 1341 215121_x_at CYAT1 /// IGLC1 /// IGLV1 - 1376 217272 s at SERPINB13

1306 214359 s at HSP90AB1 44 1377 217388 s at KYNU

1307 214366 s at ALOX5 1342 215176 x at LOC642838 1378 217418 x at MS4A1

1308 214370 at S100A8 1343 215193_x_at HLA-DRB1 /// HLA-DRB3 1379 217478 s at HLA-DMA

1309 214414 x at HBA1 /// HBA2 /// HLA-DRB4 /// 1380 217502 at IFIT2

1310 214439 x at BIN1 LOC 100507709 /// 1381 217523 at CD44

131 1 214453 s at IFI44 LOC100507714 1382 217528 at CLCA2

1312 214455_at HIST1 H2BC /// 1344 215223 s at LOC100129518 /// SOD2 1383 217678 at SLC7A1 1

HIST1 H2BE /// 1345 215294 s at SMARCA1 1384 217738 at NAMPT

HIST1 H2BF /// 1346 215342 s at RABGAP1 L 1385 217739 s at NAMPT

HIST1 H2BG /// HIST1 H2BI 1347 215379 x at IGLV1 -44 1386 217744 s at PERP

1313 214456 x at SAA1 /// SAA2 1348 215388 s at CFH /// CFHR1 1387 217767 at C3

1314 214464 at CDC42BPA 1349 215446 s at LOX 1388 217771 at GOLM1

1315 214467 at GPR65 1350 215506 s at DI RAS3 1389 217807 s at GLTSCR2

1316 214470 at KLRB1 1351 215633 x at LST1 1390 217820 s at ENAH

1317 21451 1 x at FCGR1 B 1352 215646 s at VCAN 1391 217838 s at EVL

1318 214549 x at SPRR1 A 1353 215726 s at CYB5A 1392 217848 s at PPA1

1319 214567 s at XCL1 /// XCL2 1354 215785 s at CYFIP2 1393 217853 at TNS3

1394 217867 x at BACE2 1434 218729 at LXN 1473 219423 x at TNFRSF25

1395 217890 s at PARVA 1435 218736 s at PALMD 1474 219434 at TREM1

1396 217892 s at LIMA1 1436 218764 at PRKCH 1475 219452 at DPEP2

1397 217901 at DSG2 1437 218802 at CCDC109B 1476 219471 at KIAA0226L

1398 21791 1 s at BAG3 1438 218805_at GIMAP1 -GIMAP5 /// 1477 219476 at C1 orf1 16

1399 217963 s at NGFRAP1 GIMAP5 1478 219479 at KDELC1

1400 217966 s at FAM129A 1439 218854 at DSE 1479 219489 s at NXN

1401 217967 s at FAM129A 1440 218856 at TNFRSF21 1480 219497 s at BCL1 1 A

1402 217975 at WBP5 1441 218870 at ARHGAP15 1481 219498 s at BCL1 1 A

1403 217977 at MSRB1 1442 218876 at TPPP3 1482 219505 at CECR1

1404 217979 at TSPAN13 1443 218885 s at GALNT12 1483 219528 s at BCL1 1 B

1405 217996 at PHLDA1 1444 218901 at PLSCR4 1484 219529 at CLIC3

1406 217997 at PHLDA1 1445 218918 at MAN1 C1 1485 219563 at LINC00341

1407 217999 s at PHLDA1 1446 218932 at ZNHIT6 1486 219569 s at SLC35G2

1408 218025 s at ECI2 1447 218963 s at KRT23 1487 219574 at MARCH1

1409 218027 at MRPL15 1448 218986 s at DDX60 1488 219580 s at TMC5

1410 218035 s at RBM47 1449 218990 s at SPRR3 1489 219630 at PDZK1 IP1

141 1 218100 s at IFT57 1450 218995 s at EDN1 1490 219637 at ARMC9

1412 218186 at RAB25 1451 219014 at PLAC8 1491 219666 at MS4A6A

1413 218237 s at SLC38A1 1452 219067 s at NSMCE4A 1492 219667 s at BANK1

1414 218254 s at SAR1 B 1453 219073 s at OSBPL10 1493 219681 s at RAB1 1 FIP1

1415 21831 1 at MAP4K3 1454 219093 at PI D1 1494 219682 s at TBX3

1416 218326 s at LGR4 1455 219134 at ELTD1 1495 219684 at RTP4

1417 218330 s at NAV2 1456 219159 s at SLAMF7 1496 219727 at DUOX2

1418 218353 at RGS5 1457 219179 at DACT1 1497 219734 at SIDT1

1419 218404 at SNX10 1458 219191 s at BIN2 1498 219762 s at RPL36

1420 218454 at PLBD1 1459 219201 s at TWSG1 1499 219777 at GIMAP6

1421 218468 s at GREM1 1460 219209 at I FIH1 1500 219778 at ZFPM2

1422 218469 at GREM1 1461 21921 1 at USP18 1501 219787 s at ECT2

1423 218501 at ARHGEF3 1462 219243 at GIMAP4 1502 219795 at SLC6A14

1424 218541 s at C8orf4 1463 219256 s at SH3TC1 1503 219799 s at DHRS9

1425 218559 s at MAFB 1464 219263 at RNF128 1504 219812 at PVRIG

1426 218561 s at LYRM4 1465 219274 at TSPAN12 1505 219892 at TM6SF1

1427 218589 at LPAR6 1466 219279 at DOCK10 1506 219922 s at LTBP3

1428 218638 s at LOC100130872 /// SPON2 1467 219288 at C3orf14 1507 219936 s at GPR87

1429 218651 s at LARP6 1468 219293 s at OLA1 1508 219947 at CLEC4A

1430 218694 at ARMCX1 1469 219304 s at PDGFD 1509 219962 at ACE2

1431 218696 at EIF2AK3 1470 219352 at HERC6 1510 219985 at HS3ST3A1

1432 218718 at PDGFC 1471 219371 s at KLF2 151 1 219995 s at ZNF750

1433 218723 s at RGCC 1472 219410 at TMEM45A 1512 220005 at P2RY13

1513 220030 at STYK1 LOC100294406 1586 222500 at PPIL1

1514 220059 at STAP1 1547 221698 s at CLEC7A 1587 222549 at CLDN1

1515 220066 at NOD2 1548 221724 s at CLEC4A 1588 222608 s at ANLN

1516 220088 at C5AR1 1549 221729 at COL5A2 1589 222668 at KCTD15

1517 220199 s at AIDA 1550 221730 at COL5A2 1590 222686 s at CPPED1

1518 220330 s at SAMSN1 1551 221731 x at VCAN 1591 222693 at FNDC3B

1519 220542 s at BPIFA1 1552 221748 s at TNS1 1592 222717 at SDPR

1520 220945 x at MANSC1 1553 221773 at ELK3 1593 222750 s at SRD5A3

1521 220952 s at PLEKHA5 1554 221775 x at RPL22 1594 222802 at EDN1

1522 220960 x at RPL22 1555 221802 s at KIAA1598 1595 222830 at GRHL1

1523 220999 s at CYFI P2 1556 221841 s at KLF4 1596 222834 s at GNG12

1524 22101 1 s at LBH 1557 221872 at RARRES1 1597 222838 at SLAMF7

1525 221024 s at SLC2A10 1558 221879 at CALML4 1598 222858 s at DAPP1

1526 221080 s at DENND1 C 1559 221884 at MECOM 1599 222859 s at DAPP1

1527 221081 s at DENND2D 1560 22191 1 at ETV1 1600 222877 at

1528 221 122 at HRASLS2 1561 221935 s at EOGT 1601 222885 at EMCN

1529 221210 s at NPL 1562 221958 s at WLS 1602 222890 at CCDC1 13

1530 221234 s at BACH2 1563 221969 at PAX5 1603 222891 s at BCL1 1 A

1531 221239 s at FCRL2 1564 222016 s at ZNF323 1604 222895 s at BCL1 1 B

1532 221253_s_at MUTED-TXNDC5 /// 1565 222040 at HNRNPA1 1605 222915 s at BANK1

TXNDC5 1566 222043 at CLU 1606 222934 s at CLEC4E

1533 221261_x_at MAGED4 /// MAGED4B /// 1567 222062 at IL27RA 1607 223027 at SNX9

SNORA1 1 D /// SNORA1 1 E 1568 222071 s at SLC04C1 1608 223044 at SLC40A1

1534 221491_x_at HLA-DRB1 /// HLA-DRB3 1569 222108 at AMIG02 1609 223062 s at PSAT1

/// HLA-DRB4 /// HLA- 1570 222146 s at TCF4 1610 223090 x at VEZT DRB5 /// LOC100507709 1571 222150 s at PION 161 1 223096 at NOP58 /// LOC100507714 /// 1572 222154 s at SPATS2L 1612 223125 s at C1 orf21 LOC100509582 1573 222162 s at ADAMTS1 1613 223170 at TMEM98

1535 221538 s at PLXNA1 1574 222218 s at PILRA 1614 223204 at FAM198B

1536 221541 at CRISPLD2 1575 222258 s at SH3BP4 1615 223249 at CLDN12

1537 221558 s at LEF1 1576 222392 x at PERP 1616 223278 at GJB2

1538 221561 at SOAT1 1577 222404 x at PTPLAD1 1617 223279 s at UACA

1539 221577 x at GDF15 1578 222416 at ALDH18A1 1618 223280 x at MS4A6A

1540 221581 s at LAT2 1579 222433 at ENAH 1619 223315 at NTN4

1541 221584 s at KCNMA1 1580 222446 s at BACE2 1620 223322 at RASSF5

1542 221601 s at FAIM3 1581 222453 at CYBRD1 1621 223343 at MS4A7

1543 221602 s at FAIM3 1582 222455 s at PARVA 1622 223344 s at MS4A7

1544 221651_x_at IGK@ /// IGKC /// 1583 222457 s at LIMA1 1623 223395 at ABI3BP

LOC100294406 1584 222486 s at ADAMTS1 1624 223405 at NPL

1545 221667 s at HSPB8 1585 222496 s at RBM47 1625 223422 s at ARHGAP24

1546 221671 x at IGK@ /// IGKC ///

1626 223434 at GBP3 1666 224719 s at C12orf57 1705 225207 at PDK4

1627 223454 at CXCL16 1667 224724 at SULF2 1706 225220 at SNHG8

1628 223463 at RAB23 1668 224740 at C5orf43 1707 225242 s at CCDC80

1629 223475 at CRISPLD1 1669 224759 s at C12orf23 1708 225262 at FOSL2

1630 223484 at C15orf48 1670 224764 at ARHGAP21 1709 225275 at EDIL3

1631 223501 at TNFSF13B 1671 224795_x_at IGK@ /// IGKC /// 1710 225282 at SMAP2

1632 223502 s at TNFSF13B LOC100294406 171 1 225285 at BCAT1

1633 223553 s at DOK3 1672 224799 at NDFI P2 1712 225308 s at TANC1

1634 223562 at PARVG 1673 224802 at NDFI P2 1713 225331 at CCDC50

1635 223631 s at C19orf33 1674 224819 at TCEAL8 1714 225342 at AK4 /// LOC 100507855

1636 223640 at HCST 1675 224822 at DLC1 1715 225344 at NCOA7

1637 223681 s at INADL 1676 224823 at MYLK 1716 225373 at C10orf54

1638 223734 at MGARP 1677 224833 at ETS1 1717 225381 at MI R100HG

1639 223748 at SLC4A1 1 1678 224862 at GNAQ 1718 225384 at DOCK7

1640 223775 at HHIP 1679 224894 at YAP1 1719 225406 at TWSG1

1641 223836 at FGFBP2 1680 224895 at YAP1 1720 225407 at MBP

1642 223922 x at MS4A6A 1681 224909 s at PREX1 1721 225442 at DDR2

1643 223952 x at DHRS9 1682 22491 1 s at DCBLD2 1722 225464 at FRMD6

1644 224002 s at FKBP7 1683 224917 at MIR21 1723 225481 at FRMD6

1645 224009 x at DHRS9 1684 224918 x at MGST1 1724 225496 s at SYTL2

1646 224159 x at TRIM4 1685 224925 at PREX1 1725 225502 at DOCK8

1647 224341 x at TLR4 1686 224937 at PTGFRN 1726 225525 at KIAA1671

1648 224352 s at CFL2 1687 224940 s at PAPPA 1727 225548 at SHROOM3

1649 224356 x at MS4A6A 1688 224941 at PAPPA 1728 225564 at SPATA13

1650 224367 at BEX2 1689 224955 at TEAD1 1729 225589 at SH3RF1

1651 224435 at FAM213A 1690 224964 s at GNG2 1730 225612_s_at B3GNT5

1652 224451 x at ARHGAP9 1691 224983 at SCARB2 LOC100505668

1653 224463 s at C1 1 orf70 1692 224996 at ASPH 1731 225613 at MAST4

1654 224480 s at AGPAT9 1693 224999 at EGFR 1732 225645 at EHF

1655 224516 s at CXXC5 1694 225008 at ASPH 1733 225662 at ZAK

1656 224560 at TIMP2 1695 225018 at SPI RE1 1734 225664 at COL12A1

1657 224579 at SLC38A1 1696 225060 at LRP1 1 1735 225667 s at FAM84A

1658 224593 at ZNF664 1697 225078 at EMP2 1736 225681 at CTHRC1

1659 224650 at MAL2 1698 225079 at EMP2 1737 225685 at CDC42EP3

1660 224657 at ERRFI1 1699 225105 at C12orf75 1738 225688 s at PHLDB2

1661 224663 s at CFL2 1700 225107 at HNRNPA2B1 1739 225698 at EPB41 L4A-AS1

1662 224694 at ANTXR1 1701 225162 at SH3D19 1740 225701 at AKNA

1663 224707 at CYSTM1 1702 225188 at RAPH1 1741 225710 at GNB4

1664 224710 at NARR /// RAB34 1703 225189 s at RAPH1 1742 225728 at SORBS2

1665 224714 at MKI67I P 1704 225202 at RHOBTB3 1743 225731 at ANKRD50

1744 225763 at RCSD1 1775 226103 at NEXN 1815 226659 at DEF6

1745 225768 at NR1 D2 1776 2261 12 at SGCB 1816 226676 at ZNF521

1746 225782 at MSRB3 1777 226120 at TTC8 1817 226677 at ZNF521

1747 225786 at HNRNPU-AS1 1778 226147 s at PIGR 1818 226682 at RORA

1748 225795 at C22orf32 1779 226184 at FMNL2 1819 226694 at AKAP2 /// PALM2-AKA

1749 225806 at AJUBA 1780 226185 at CDS1 1820 226695 at PRRX1

1750 225812 at C6orf225 1781 226189 at ITGB8 1821 226697 at FAM1 14A1

1751 225817 at CGNL1 1782 226213 at ERBB3 1822 226702 at CMPK2

1752 225835 at SLC12A2 1783 226218 at IL7R 1823 226725 at

1753 225842 at PHLDA1 1784 226219 at ARHGAP30 1824 226751 at CNRIP1

1754 225846 at ESRP1 1785 226225 at MCC 1825 226752 at F AM 174 A

1755 225847 at NCEH1 1786 226237 at COL8A1 1826 226757 at IFIT2

1756 225872 at SLC35F5 1787 226244 at CLEC14A 1827 226789 at EMB

1757 225883 at ATG16L2 1788 226267 at JDP2 1828 226790 at MORN2

1758 225897 at MARCKS 1789 226272 at RCAN3 1829 226810 at OGFRL1

1759 225899_x_at FLJ45340 /// FLJ45445 /// 1790 226275 at MXD1 1830 226817 at DSC2

LOC100128326 /// 1791 226279 at PRSS23 1831 226818 at MPEG1

LOC100132050 /// 1792 226281 at DNER 1832 226834 at

LOC 100287894 /// 1793 226282 at PTPN14 1833 226837 at SPRED1

LOC 100289306 /// 1794 226302 at ATP8B1 1834 226841 at MPEG1

LOC 100506479 /// 1795 226322 at TMTC1 1835 226847 at FST

LOC 100508632 /// 1796 226333 at IL6R 1836 226865 at LOC100509635 LOC 100652945 /// 1797 226337 at GORAB 1837 226875 at DOCK1 1

LOC100653241 /// 1798 226364 at HI P1 1838 226876 at FAM101 B

LOC 100653346 ///

1799 226380 at PTPN21 1839 226878 at HLA-DOA

LOC729737

1800 226420 at MECOM 1840 226880 at NUCKS1

1760 225922 at FNIP2

1801 226430 at RELL1 1841 226905 at FAM101 B

1761 225946 at RASSF8

1802 226436 at RASSF4 1842 226908 at LRIG3

1762 225987 at STEAP4

1803 226459 at PIK3AP1 1843 226960 at CXCL17

1763 226000 at CTTNBP2NL

1804 226482 s at TSTD1 1844 226991 at NFATC2

1764 226021 at RDH10

1805 226490 at NHSL1 1845 227013 at LATS2

1765 226022 at SASH1

1806 226517 at BCAT1 1846 227027 at GFPT1

1766 226028 at ROB04

1807 226534 at KITLG 1847 227030 at IKZF3

1767 226039 at MGAT4A

1808 226545 at CD109 1848 227034 at SOWAHC

1768 226051 at SELM

1809 226548 at SBK1 1849 227038 at SGMS2

1769 226064 s at DGAT2

1810 226576 at ARHGAP26 1850 227051 at

1770 226067 at BPIFB1

181 1 226600 at TMTC3 1851 227070 at GLT8D2

1771 226068 at SYK

1812 226621 at OSMR 1852 227080 at ZNF697

1772 226069 at PRICKLE1

1813 226622 at MUC20 1853 227099 s at C1 1 orf96

1773 226084 at MAPI B

1814 226641 at ANKRD44 1854 227123 at RAB3B

1774 226099 at ELL2

1855 227134 at SYTL1 1894 227623 at CACNA2D1 1934 228128 x at PAPPA

1856 227140 at INHBA 1895 227628 at GPX8 1935 228141 at GPX8

1857 227152 at C12orf35 1896 227645 at PIK3R5 1936 228153 at RNF144B

1858 227184 at PTAFR 1897 227646 at EBF1 1937 228155 at FAM213A

1859 227195 at ZNF503 1898 227647 at KCNE3 1938 228157 at ZNF207

1860 227196 at RHPN2 1899 227677 at JAK3 1939 228167 at KLHL6

1861 227198 at AFF3 1900 227686 at OXNAD1 1940 228176 at S1 PR3

1862 227210 at SFMBT2 1901 227688 at LRCH2 1941 228241 at AGR3

1863 227223 at RBM39 1902 227692 at GNAI 1 1942 228256 s at EPB41 L4A

1864 227232 at EVL 1903 227697 at SOCS3 1943 228258 at TBC1 D10C

1865 227238 at MUC15 1904 227702 at CYP4X1 1944 228266 s at HDGFRP3

1866 227241 at MUC15 1905 227725 at ST6GALNAC1 1945 228283 at CMC1

1867 227261 at KLF12 1906 227769 at GPR27 1946 228284 at TLE1

1868 227265 at FGL2 1907 227780 s at ECSCR 1947 228297 at

1869 227266 s at FYB 1908 227792 at ITPRI PL2 1948 228298 at PCED1 B

1870 227289 at PCDH17 1909 227798 at SMAD1 1949 228314 at LRRC8C

1871 227291 s at BOLA3 1910 227799 at MY01 G 1950 228332 s at C1 1 orf31

1872 227295 at IKBI P 191 1 227803 at ENPP5 1951 228333 at ZEB2

1873 227314 at ITGA2 1912 22781 1 at FGD3 1952 228335 at CLDN1 1

1874 227344 at IKZF1 1913 227812 at TNFRSF19 1953 228339 at ECSCR

1875 227345 at TNFRSF10D 1914 227828 s at FAM176A 1954 228347 at SIX1

1876 227346 at IKZF1 1915 227850 x at CDC42EP5 1955 228365 at CPNE8

1877 227353 at TMC8 1916 227856 at C4orf32 1956 228372 at C10orf128

1878 227354 at PAG1 1917 227875 at KLHL13 1957 228390 at RAB30

1879 227361 at HS3ST3B1 1918 227889 at LPCAT2 1958 228408 s at SDAD1

1880 227372 s at BAIAP2L1 1919 227929 at LIN7A 1959 228423 at MAP9

1881 227383 at LOC727820 1920 227947 at PHACTR2 1960 228442 at NFATC2

1882 227384_s_at LOC727820 /// LOC728855 1921 227948 at FGD4 1961 228471 at ANKRD44

/// LOC728875 1922 227952 at 1962 228532 at C1 orf162

1883 227399 at VGLL3 1923 227960 s at FAHD1 1963 228575 at IL20RB

1884 227410 at FAM43A 1924 227961 at CTSB 1964 228585 at ENTPD1

1885 227449 at EPHA4 1925 227998 at S100A16 1965 228592 at MS4A1

1886 227475 at FOXQ1 1926 228033 at E2F7 1966 228624 at TMEM144

1887 227481 at CNKSR3 1927 228038 at SOX2 1967 228635 at PCDH10

1888 227484 at SRGAP1 1928 228053 s at TOMM5 1968 228640 at PCDH7

1889 227530 at AKAP12 1929 228055 at NAPSB 1969 228658 at MIAT

1890 227542 at SOCS6 1930 228063 s at NAP1 L5 1970 228661_s_at LOC 100506029

1891 227554 at MAGI2-AS3 1931 228067 at C2orf55 LOC100506051

1892 227566 at LOC100653217 III NTM 1932 228071 at GIMAP7 1971 228698 at SOX7

1893 227607 at STAMBPL1 1933 228094 at AMICA1 1972 228708 at RAB27B

1973 228748 at CD59 2013 229670 at 2052 231 130 at FKBP7

1974 228762 at LFNG 2014 229686 at P2RY8 2053 231 166 at GPR155

1975 228766 at CD36 2015 229723 at TAGAP 2054 231202 at ALDH1 L2

1976 228771 at ADRBK2 2016 229872_s_at LOC100132999 /// 2055 231227 at WNT5A

1977 228776 at GJC1 LOC642441 /// LOC730256 2056 231274 s at

1978 228824 s at PTGR1 2017 229910 at SHE 2057 231577 s at GBP1

1979 228827 at RUNX1 T1 2018 229937 x at 2058 231579 s at TIMP2

1980 228846 at MXD1 2019 229952 at 2059 231597 x at

1981 228854 at 2020 230040 at ADAMTS18 2060 231644 at

1982 228863 at PCDH17 2021 230061 at TM4SF18 2061 231647 s at FCRL5

1983 228865 at C1 orf1 16 2022 230093 at RSPH1 2062 231729 s at CAPS

1984 228869 at SNX20 2023 230135 at HHI P 2063 231735 s at MALAT1

1985 228904 at HOXB3 2024 230147 at F2RL2 2064 231736 x at MGST1

1986 228949 at WLS 2025 230175 s at DCBLD2 2065 231747 at CYSLTR1

1987 228950 s at WLS 2026 230179 at LOC285812 2066 231766 s at COL12A1

1988 228964 at PRDM1 2027 230180 at DDX17 2067 231776 at EOMES

1989 229012 at C9orf24 2028 230245 s at LOC283663 2068 231873 at BMPR2

1990 229041 s at LOC100505746 2029 230250 at PTPRB 2069 231897 at PTGR1

1991 229072 at RAB30 2030 230263 s at DOCK5 2070 231929 at IKZF2

1992 229074 at EHD4 2031 230264 s at AP1 S2 2071 231941 s at MUC20

1993 229218 at COL1 A2 2032 230270 at PRPF38B 2072 231947 at MYCT1

1994 229225 at NRP2 2033 230323 s at TMEM45B 2073 232001 at LOC439949

1995 229228 at CREB5 /// LOC401317 2034 230333 at 2074 232024 at GIMAP2

1996 229331 at SPATA18 2035 230372 at HAS2 2075 232056 at SCEL

1997 229353 s at NUCKS1 2036 230378 at SCGB3A1 2076 232080 at HECW2

1998 229367 s at GIMAP6 2037 230383 x at 2077 232082 x at SPRR3

1999 229383 at MARCH1 2038 230389 at FNBP1 2078 2321 13 at

2000 229390 at FAM26F 2039 230391 at CD84 2079 232210 at

2001 229391 s at FAM26F 2040 230464 at S1 PR5 2080 232213 at PELI1

2002 229434 at 2041 230494 at SLC20A1 2081 232231 at RUNX2

2003 229450 at IFIT3 2042 230550 at MS4A6A 2082 232235 at DSEL

2004 229461 x at NEGRI 2043 230707 at SORL1 2083 232304 at PELI1

2005 229498 at MBNL3 2044 230741 at 2084 232431 at NR3C1

2006 229513 at STRBP 2045 230746 s at 2085 232489 at TRMT13

2007 229542 at C20orf85 2046 230805 at 2086 232543 x at ARHGAP9

2008 229560 at TLR8 2047 230925 at APBB1 I P 2087 232614 at

2009 229563 s at RPL10A 2048 230970 at 2088 232615 at

2010 229584 at LRRK2 2049 231077 at C1 orf 92 2089 2326 7 at CTSS

201 1 229597 s at WDFY4 2050 231093 at FCRL3 2090 232629 at PROK2

2012 229625 at GBP5 2051 231 124 x at LY9 2091 232843 s at DOCK8

2092 232914 s at SYTL2 2131 235670 at STX1 1 2169 238430 x at SLFN5

2093 233364 s at 2132 235735 at TNFSF8 2170 238513 at PRRG4

2094 233555 s at SULF2 2133 235737 at TSLP 2171 238542 at ULBP2

2095 233849 s at ARHGAP5 2134 235740 at MCTP1 2172 238558 at

2096 233955 x at CXXC5 2135 235879 at 2173 238581 at GBP5

2097 234000 s at PTPLAD1 2136 235919 at CEP78 2174 238623 at

2098 234032 at 2137 235944 at HMCN1 2175 238668 at

2099 234151 at 2138 235964 x at SAMHD1 2176 238669 at PTGS1

2100 234339 s at GLTSCR2 2139 236085 at CAPSL 2177 238689 at GPR1 10

2101 234491 s at SAV1 2140 236129 at GALNT5 2178 238720 at LOC100506582

2102 234675 x at 2141 236140 at GCLM 2179 238756 at GAS2L3

2103 234764_x_at CKAP2 /// IGLC1 /// IGLV1 - 2142 236179 at CDH1 1 2180 238778 at MPP7

44 2143 236193 at HIST1 H2BC 2181 238846 at TNFRSF1 1 A

2104 234949 at FRG1 B 2144 236203_at HLA-DQA1 /// 2182 239135 at CPPED1

2105 234970 at TC2N LOC100507718 /// 2183 239150 at SNTN

2106 234986 at GCLM LOC100509457 2184 239294 at

2107 234987 at SAMHD1 2145 236262 at MMRN2 2185 239587 at

2108 234994 at TMEM200A 2146 236280 at 2186 239597 at

2109 235023 at VPS13C 2147 236293 at RHOH 2187 239629 at CFLAR

21 10 235046 at INPP4B 2148 236295 s at MIR3929 /// NLRC3 2188 239744 at

21 1 1 235075 at DSG3 2149 236297 at 2189 239893 at

21 12 235086 at THBS1 2150 236379 at 2190 240061 at

21 13 235142 at ZBTB8A 2151 236439 at 2191 240065 at FAM81 B

21 14 235144 at RASEF 2152 236489 at GPR1 10 2192 240161 s at CDC20B

21 15 235146 at TMCC3 2153 236539 at PTPN22 2193 240259 at FLRT2 /// LOC1005067

21 16 235171 at LOC100505501 2154 236565 s at LARP6 2194 240304 s at TMC5

21 17 235199 at RNF125 2155 236656 s at LOC10028891 1 2195 240572 s at LOC374443

21 18 235213 at ITPKB 2156 236841 at LOC100134445 2196 240665 at

21 19 235306 at GIMAP8 2157 236907 at 2197 240830 at SCARNA17

2120 235318 at FBN1 2158 237009 at 2198 240890 at LOC643733

2121 235385 at MARCH1 2159 237466 s at HHI P 2199 241068 at

2122 235391 at FAM92A1 2160 237625 s at 2200 241412 at BTC

2123 235421 at MAP3K8 2161 238002 at GOLIM4 2201 241435 at

2124 235458 at HAVCR2 2162 238017 at SDR16C5 2202 241681 at

2125 235489 at RHOJ 2163 238021 s at CRNDE 2203 242008 at

2126 235518 at SLC8A1 2164 238063 at TMEM154 2204 242093 at SYTL5

2127 235529 x at SAMHD1 2165 238066 at RBP7 2205 242146 at SNRPA1

2128 235567 at RORA 2166 2381 16 at DYNLRB2 2206 242268 at CELF2

2129 235629 at 2167 238327 at ODF3B 2207 242352 at NIPBL

2130 235651 at TTC22 2168 238429 at TMEM71 2208 242625 at RSAD2

Probe* Set.lD** Gene Symbol Probe* Set.lD** Gene Symbol

2209 242695 at 2249 74694 s at RABEP2

2210 242814 at SERPINB9 2250 91816 f at MEX3D

221 1 242862 x at probe number in the microarray

2212 242871 at PAQR5

2213 242903 at IFNGR1 Affymetrix U133 Plus 2.0

2214 242907 at GBP2

2215 242946 at CD53 ^** : Set.lD in the microarray Affymetrix

2216 243109 at MCTP2 U133 Plus 2.0

2217 243154 at

2218 243296 at NAMPT

2219 243395 at

2220 243489 at

2221 243509 at

2222 243610 at C9orf135

2223 243780 at

2224 244008 at PARP8

2225 244023 at SYK

2226 244313 at CR1

2227 244654 at MY01 G

2228 266 s at CD24

2229 31874 at GAS2L1

2230 33304 at ISG20

2231 33323 r at SFN

2232 34210 at CD52

2233 35974 at LRMP

2234 3671 1 at MAFF

2235 37145 at GNLY

2236 38149 at ARHGAP25

2237 39248 at AQP3

2238 39549 at NPAS2

2239 39729 at PRDX2

2240 40562 at GNA1 1

2241 41469 at PI3

2242 41577 at PPP1 R16B

2243 44790 s at KIAA0226L

2244 53071 s at C17orf101

2245 57082 at LDLRAP1

2246 58780 s at ARHGEF40

2247 64408 s at CALML4

2248 64900 at TMEM231

Table 2 : Alternative list of analyzed genes Probe* Set.lD** Gene.Symbol Probe* Set.lD** Gene.Symbol

1404 217979 at TSPAN13 859 208923 at CYFI P1

Probe* Set.lD** Gene.Symbol 191 201669 s at MARCKS 156 201334 s at ARHGEF12

983 210027 s at APEX1 1399 217963 s at NGFRAP1 1019 210512 s at VEGFA

1295 214042 s at RPL22 1997 229353 s at NUCKS1 242 202071 at SDC4

1 130 212077 at CALD1 101 200999 s at CKAP4 98 200983 x at CD59

1576 222392 x at PERP 163 201438 at COL6A3 1 1 19 21 1980 at COL4A1

1343 215193_x_at HLA-DRB1 /// HLA- 140 201243 s at ATP1 B1 813 207812 s at GORASP2

DRB3 /// HLA-DRB4 208 201841 s at HSPB1 213 201852 x at COL3A1

/// LOC 100507709 /// 1683 224917 at MIR21 1037 210809 s at POSTN

LOC100507714

196 201690 s at TPD52 125 201 141 at GPNMB

137 201215 at PLS3 274 202336 s at PAM 395 203186 s at S100A4

1 17 201 105 at LGALS1 179 201596 x at KRT18 201 201739 at SGK1

161 201422 at IFI30

270 202295 s at CTSH 1579 222433 at ENAH

130 201 160 s at CSDA

123 201 131 s at CDH1 1353 215726 s at CYB5A

1658 224593 at ZNF664 1 122 21 1991 s at HLA-DPA1 1 125 212018 s at RSL1 D1

1 144 212195 at IL6ST 1577 222404 x at PTPLAD1 1026 210645 s at TTC3 /// TTC3P1

1 1 15 21 1962 s at ZFP36L1

14 1553678 a at ITGB1 1 13 201060 x at STOM

1053 210986 s at TPM1

822 208029 s at LAPTM4B 1928 228053 s at TOMM5

279 202351 at ITGAV

75 200675 at CD81 79 200765 x at CTNNA1

1338 215076 s at COL3A1 70 200636 s at PTPRF 995 210139 s at PMP22

172 201560 at CLIC4 809 207738 s at NCKAP1 1668 224740 at C5orf43

1498 219762 s at RPL36

840 208747 s at C1 S 742 206323 x at OPHN1

186 201653 at CNIH

947 209684 at RIN2 190 201667 at GJA1

146 201288 at ARHGDIB

2097 234000 s at PTPLAD1 561 204517 at PPIC

1092 21 1684 s at DYNC1 I2 1203 212958 x at PAM 1572 222154 s at SPATS2L

287 202403 s at COL1 A2 487 203973 s at CEBPD 284 202381 at ADAM9

577 204670_x_at HLA-DRB1 /// HLA-

837 208690 s at PDLIM1 849 208836 at ATP1 B3

DRB4 ///

643 205133 s at HSPE1 1 160 212397 at RDX

LOC 100507709 ///

1468 219293 s at OLA1 258 202232 s at EIF3M

LOC100507714

134 201 177 s at UBA2 188 201659 s at ARL1

1347 215379 x at IGLV1 -44

967 209861 s at METAP2 1385 217739 s at NAMPT

161 1 223096 at NOP58

592 204744 s at IARS 1 170 212509 s at MXRA7

160 201417 at SOX4

375 203041 s at LAMP2 1 184 212667_at LOC100505813 /

305 202546 at VAMP8

236 20201 1 at TJP1 SPARC

88 200878_at EPAS1 ///

138 201218 at CTBP2 185 201650 at KRT19

LOC100652809

124 201 137 s at HLA-DPB1 1 158 212372 at MYH10

100 200985 s at CD59

139 201242 s at ATP1 B1 217 201876 at PON2

95 200972 at TSPAN3

1908 227792 at ITPRI PL2 99 200984 s at CD59

1072 21 1430_s_at IGHG1 /// IGHG2 ///

030 210715 s at SPINT2 182 201631 s at IER3

IGHM /// IGHV4-31 1

2058 231579 s at TIMP2 200 201721 s at LAPTM5 1 14 201061 s at STOM

Probe* Set.lD** Gene.Symbol Probe* Set.lD** Gene.Symbol Probe* Set.lD** Gene.Symbol

1062 21 1 161 s at COL3A1 136 201212 at LGMN 71 200648 s at GLUL

1291 213975 s at LYZ 1 151 212314 at SEL1 L3 882 209135 at ASPH

1 1 16 21 1964 at COL4A2 1301 214214 s at C1 QBP 153 201310 s at NREP

2127 235529 x at SAMHD1 848 208820_at LOC 100653024 /// 853 208886 at H1 F0

1082 21 1623 s at FBL LOC100653146 /// 834 208662 s at TTC3 /// TTC3P1

1387 217767 at C3 PTK2 1371 217028 at CXCR4

1659 224650 at MAL2 1054 210987 x at TPM1 789 207173 x at CDH1 1

1924 227961 at CTSB 157 201360 at CST3 91 200923 at LGALS3BP

1 192 212761 at TCF7L2 1 146 212226 s at PPAP2B 1364 216834 at RGS1

260 202241 at TRIB1 40 1555812 a at ARHGDIB 376 203042 at LAMP2

68 200602 at APP 1 159 212386 at TCF4 108 201028 s at CD99

1325 214669 x at IGKC 31 1 202609 at EPS8 909 209335 at DCN

1656 224560 at TIMP2 884 209146 at MSM01 1249 213455 at FAM1 14A1

1 1 17 21 1971 s at LRPPRC 259 202237 at NNMT 74 200670 at XBP1

1666 224719 s at C12orf57 2239 39729 at PRDX2 1758 225897 at MARCKS

89 200897 s at PALLD 1397 217901 at DSG2 1 181 212614 at ARID5B

214 201858 s at SRGN 104 201009 s at TXNIP 1370 217022_s_at IGH@ /// IGHA1 /

831 208636 at ACTN1 1 178 212592 at IGJ IGHA2

105 201012 at ANXA1 359 202933 s at YES1 1284 213891 s at TCF4

910 209340 at UAP1 212 201849 at BNI P3 227 201946 s at CCT2

251 202133 at WWTR1 918 209386 at TM4SF1 282 202371 at TCEAL4

850 208843 s at GORASP2 1748 225795 at C22orf32 1 16 201069 at MMP2

1947 228297 at 1551 221731 x at VCAN 285 202388 at RGS2

131 201 161 s at CSDA 147 201289 at CYR61 1390 217820 s at ENAH

1676 224823 at MYLK 1329 214953 s at APP 574 204620 s at VCAN

207 201839 s at EPCAM 1 143 212192 at KCTD12 363 202948 at IL1 R1

1099 21 1747 s at LSM5 1669 224759 s at C12orf23 1 164 212460 at SPTSSA

1677 224833 at ETS1 2161 238002 at GOLIM4 78 200755 s at CALU

150 201300 s at PRNP 154 201324 at EMP1 1819 226694_at AKAP2 /// PALM

248 202087 s at CTSL1 1 12 201059 at CTTN AKAP2

2138 235964 x at SAMHD1 1715 225344 at NCOA7 219 201887 at IL13RA1

12 1553530 a at ITGB1 324 202688 at TNFSF10 1608 223044 at SLC40A1

81 200771 at LAMC1 1662 224694 at ANTXR1 1 140 212169 at FKBP9

374 203038 at PTPRK 353 202902 s at CTSS 1689 224955 at TEAD1

1706 225220 at SNHG8 1925 227998 at S100A16 1393 217853 at TNS3

1402 217975 at WBP5 288 202404 s at COL1 A2 1396 217892 s at LIMA1

1871 227291 s at BOLA3 195 201689 s at TPD52 229 201952 at ALCAM

858 208910 s at C1 QBP 1425 218559 s at MAFB 1 127 212067 s at C1 R

940 209609 s at MRPL9 1663 224707 at CYSTM1 1702 225188 at RAPH1

205 201798 s at MYOF 1610 223090 x at VEZT 1719 225406 at TWSG1

1073 21 1458_s_at GABARAPL1 /// 1578 222416 at ALDH18A1 1410 218035 s at RBM47

GABARAPL3 237 202016 at MEST 1412 218186 at RAB25

549 204405 x at DIMT1 484 203935 at ACVR1 1739 225698 at EPB41 L4A-AS1

77 200749 at RAN 1698 225079 at EMP2 199 201720 s at LAPTM5

162 201425 at ALDH2 1 15 201063 at RCN1 864 208981 at PECAM1

1409 218027 at MRPL15 83 200832 s at SCD 1 152 212333 at FAM98A

400 203243 s at PDLIM5 2100 234339 s at GLTSCR2 1070 21 1423 s at SC5DL

90 200907 s at PALLD 1679 224894 at YAP1 1903 227697 at SOCS3

684 205547 s at TAGLN 1665 224714 at MKI67IP 197 201697 s at DNMT1

2234 3671 1 at MAFF 348 202878 s at CD93 96 200973 s at TSPAN3

1003 210283 x at PAIP1 1845 227013 at LATS2 847 208818 s at COMT

1732 225645 at EHF 1552 221748 s at TNS1 301 202503 s at KIAA0101

870 209071 s at RGS5 269 202291 s at MGP 1071 21 1429 s at SERPINA1

842 208782 at FSTL1 1712 225308 s at TANC1 1305 214329 x at TNFSF10

865 208982 at PECAM1 1581 222453 at CYBRD1 1680 224895 at YAP1

257 202207 at ARL4C 267 202286 s at TACSTD2 1 134 212097 at CAV1

1 185 212671_s_at HLA-DQA1 /// HLA- 1614 223204 at FAM198B 1 136 212136 at ATP2B4

DQA2 /// 1375 217202 s at GLUL 854 208890 s at PLXNB2

LOC100507718 /// 1335 215051 x at AI F1 906 209303 at NDUFS4

LOC100509457 876 209109 s at TSPAN6 170 201506_at LOC 100652886 /

221 201889 at FAM3C 1202 212956 at TBC1 D9 LOC100653157 /

1 133 212096 s at MTUS1 1660 224657 at ERRFI 1 TGFBI

343 202820 at AHR 1232 213258 at TFPI 1 141 212188 at KCTD12

246 202085 at TJP2 528 204224 s at GCH1 843 208789 at PTRF

1479 219489 s at NXN 417 203416 at CD53 1047 210896 s at ASPH

103 201008 s at TXNI P 1 198 212846 at RRP1 B 483 203932 at HLA-DMB

894 209210 s at FERMT2 193 201681 s at DLG5 141 1 218100 s at IFT57

1384 217738 at NAMPT 874 209101 at CTGF 1743 225731 at ANKRD50

1 188 212698 s at SEPT10 1247 213428 s at COL6A1 1431 218696 at EIF2AK3

106 201013 s at PAICS 1 129 212074 at SUN1 916 209374 s at IGHM

159 201416 at SOX4 2103 234764_x_at CKAP2 /// IGLC1 /// 496 204017 at KDELR3

265 202283 at SERPINF1 IGLV1 -44 1853 227099 s at C1 1 orf96

471 203857 s at PDIA5 1348 215388 s at CFH /// CFHR1 141 201261 x at BGN

607 204839 at POP5 1736 225681 at CTHRC1 743 206332 s at IFI 16

387 203131 at PDGFRA 194 201688 s at TPD52 1793 226282 at PTPN14

1039 210830 s at PON2 94 200965 s at ABLIM1 1807 226534 at KITLG

273 202314 at CYP51 A1 /// LRRD1 731 2061 16 s at TPM1 1801 226430 at RELL1

867 208998 at UCP2 151 201307 at SEPT1 1 1618 223280 x at MS4A6A

128 201 150 s at TIMP3 414 203401 at PRPS2 1856 227140 at INHBA

1553 221773 at ELK3 401 203259 s at HDDC2 382 203066 at CHST15

271 202310 s at COL1 A1 827 208407_s_at CTNND1 /// TMX2- 1859 227195 at ZNF503

1 1 14 21 1959 at IGFBP5 CTNND1 873 209099 x at JAG1

899 209230 s at NUPR1 286 202391 at BASP1 380 203060 s at PAPSS2

1649 224356 x at MS4A6A 1432 218718 at PDGFC 903 209290 s at NFIB

35 1555630 a at NARR /// RAB34 378 203049 s at TTC37 174 201565 s at ID2

2107 234987 at SAMHD1 76 200696 s at GSN 1642 223922 x at MS4A6A

1536 221541 at CRISPLD2 428 203504 s at ABCA1 334 202759_s_at AKAP2 /// PALM

1414 218254 s at SAR1 B 314 202625 at LYN AKAP2

1440 218856 at TNFRSF21 1786 226237 at COL8A1 338 202766 s at FBN1

1664 224710 at NARR /// RAB34 1627 223454 at CXCL16 1 150 212298 at NRP1

2069 231897 at PTGR1 425 203476 at TPBG 1726 225525 at KIAA1671

907 209306 s at SWAP70 351 202900 s at NUP88 2095 233849 s at ARHGAP5

447 203645 s at CD163 381 203065 s at CAV1 1 120 21 1981 at COL4A1

192 201670 s at MARCKS 1 157 212364 at MY01 B 1836 226865 at LOC100509635

230 201963 at ACSL1 1517 220199 s at AI DA 1 106 21 1864 s at MYOF

2230 33304 at ISG20 1398 21791 1 s at BAG3 1360 216268 s at JAG1

240 202052 s at RAI14 2034 230333 at 1419 218404 at SNX10

1386 217744 s at PERP 373 203037 s at MTSS1 323 202687 s at TNFSF10

1379 217478 s at HLA-DMA 1812 226621 at OSMR 856 208892 s at DUSP6

2102 234675 x at 1670 224764 at ARHGAP21 586 204698 at ISG20

2244 53071 s at C17orf101 520 204174 at ALOX5AP 1286 213905 x at BGN

120 201 1 10 s at THBS1 155 201325 s at EMP1 1741 225710 at GNB4

1433 218723 s at RGCC 1087 21 1656_x_at HLA-DQB1 /// 1782 226213 at ERBB3

328 202733 at P4HA2 LOC100293977 2089 232617 at CTSS

1334 215049 x at CD163 626 204992 s at PFN2 875 209108 at TSPAN6

204 201785 at RNASE1 1733 225662 at ZAK 168 201501 s at GRSF1

1657 224579 at SLC38A1 2031 230264 s at AP1 S2 581 204682 at LTBP2

1763 226000 at CTTNBP2NL 165 201466 s at JUN 1212 213029 at NFIB

386 203126 at IMPA2 1323 214620 x at PAM 234 201998 at ST6GAL1

863 208966 x at IFI 16 1697 225078 at EMP2 1 174 212587 s at PTPRC

1754 225846 at ESRP1 244 202074 s at OPTN 1760 225922 at FNIP2

1342 215176 x at LOC642838 1 135 212104 s at RBFOX2 1833 226837 at SPRED1

1615 223249 at CLDN12 1 166 212473 s at MICAL2 233 201995 at EXT1

1774 226099 at ELL2 1091 21 1675 s at MDFIC 1032 210757 x at DAB2

1696 225060 at LRP1 1 453 203725 at GADD45A 295 202458 at PRSS23

1909 227798 at SMAD1 365 202957 at HCLS1 1829 226810 at OGFRL1

902 209289 at NFIB 1701 225162 at SH3D19 462 203780 at MPZL2

1344 215223_s_at LOC100129518 /// 855 208891 at DUSP6 1779 226184 at FMNL2

SOD2 913 209355 s at PPAP2B 1686 224937 at PTGFRN

1709 225275 at EDIL3 1945 228283 at CMC1 950 209717 at EVI5

145 201280 s at DAB2 1958 228408 s at SDAD1 1436 218764 at PRKCH

399 203216 s at MY06 1673 224802 at NDFI P2 1730 225612_s_at B3GNT5 /

1219 213095 x at AIF1 1674 224819 at TCEAL8 LOC100505668

171 1 225285 at BCAT1 181 201617 x at CALD1 1745 225768 at NR1 D2

1493 219681 s at RAB1 1 FIP1 872 209094 at DDAH1 763 206584 at LY96

1880 227372 s at BAIAP2L1 1426 218561 s at LYRM4 1703 225189 s at RAPH1

1586 222500 at PPIL1 1923 227960 s at FAHD1 1718 225384 at DOCK7

329 202741 at PRKACB 1 182 212636 at QKI 181 1 226600 at TMTC3

1555 221802 s at KIAA1598 1825 226752 at FAM174A 1424 218541 s at C8orf4

897 209218 at SQLE 1704 225202 at RHOBTB3 461 203774 at MTR

358 202932 at YES1 202 201743 at CD14 919 209387 s at TM4SF1

515 204135 at FILI P1 L 1230 213241 at PLXNC1 527 204220 at GMFG

1041 210845 s at PLAUR 1804 226482 s at TSTD1 144 201279 s at DAB2

510 2041 12 s at HNMT 397 20321 1 s at MTMR2 143 201278 at DAB2

1269 213693 s at MUC1 91 1 209348 s at MAF 39 1555778 a at POSTN

455 203753 at TCF4 209 201842 s at EFEMP1 1794 226302 at ATP8B1

176 201578 at PODXL 341 202803 s at ITGB2 756 206438 x at TCTN2

529 204232 at FCER1 G 1538 221561 at SOAT1 825 208190 s at LSR

1413 218237 s at SLC38A1 501 204048 s at PHACTR2 2169 238430 x at SLFN5

514 204122 at TYROBP 810 207761 s at METTL7A 488 203987 at FZD6

519 204173 at MYL6B 256 202206 at ARL4C 888 209191 at TUBB6

135 201 185 at HTRA1 486 203971 at SLC31 A1 2240 40562 at GNA1 1

992 210105 s at FYN 467 203827 at WIPI1 1521 220952 s at PLEKHA5

180 201616 s at CALD1 1 175 212588 at PTPRC 540 204331 s at MRPS12

1303 214247 s at DKK3 277 202345 s at FABP5 266 202284 s at CDKN1 A

169 201505 at LAMB1 2063 231735 s at MALAT1 1841 226905 at FAM101 B

770 206687 s at PTPN6 1789 226272 at RCAN3 942 209651 at TGFB1 I 1

1765 226022 at SASH1 785 207030 s at CSRP2 412 203394 s at HES1

1756 225872 at SLC35F5 356 202917 s at S100A8 1972 228708 at RAB27B

869 209070 s at RGS5 545 204363 at F3 80 200770 s at LAMC1

1031 210754 s at LYN 482 203925 at GCLM 1272 213766 x at GNA1 1

1 147 212230 at PPAP2B 1 1 1 1 21 1924 s at PLAUR 1482 219505 at CECR1

315 202626 s at LYN 2016 229872_s_at LOC100132999 /// 1388 217771 at GOLM1

1050 210970 s at IBTK LOC642441 /// 1228 213194 at ROB01

333 202748 at GBP2 LOC730256 1580 222446 s at BACE2

1524 22101 1 s at LBH 972 209901 x at AI F1 405 203324 s at CAV2

1034 210764 s at CYR61 25 1554600 s at LMNA 241 202068 s at LDLR

326 202729 s at LTBP1 944 209656 s at TMEM47 562 204518 s at PPIC

2231 33323 r at SFN 1352 215646 s at VCAN 1506 219922 s at LTBP3

1737 225685 at CDC42EP3 38 1555759 a at CCL5 289 20241 1 at IFI27

852 208885 at LCP1 1452 219067 s at NSMCE4A 1700 225107 at HNRNPA2B1

2064 231736 x at MGST1 1401 217967 s at FAM129A 551 204415 at IFI6

1830 226817 at DSC2 1415 21831 1 at MAP4K3 1331 215016_x_at DST /

1 194 212820 at DMXL2 1678 224862 at GNAQ LOC100652766

2101 234491 s at SAV1 319 202664 at WIPF1 1776 2261 12 at SGCB

164 201445 at CNN3 576 204661 at CD52 539 204319 s at RGS10

1848 227034 at SOWAHC 1713 225331 at CCDC50 792 207265 s at KDELR3

699 205709 s at CDS1 1 128 212070 at GPR56 866 208983 s at PECAM1

1585 222496 s at RBM47 388 203139 at DAPK1 512 2041 15 at GNG1 1

1446 218932 at ZNHIT6 440 203574 at NFIL3 558 204472 at GEM

1434 218729 at LXN 297 202478 at TRIB2 1 176 212589 at RRAS2

1420 218454 at PLBD1 1575 222258 s at SH3BP4 1471 219371 s at KLF2

383 203083 at THBS2 1227 213193 x at TRBC1 1056 210993 s at SMAD1

1423 218501 at ARHGEF3 2047 230925 at APBB1 I P 1 1 10 21 1919 s at CXCR4

327 202732 at PKIG 1049 210915 x at TRBC1 1728 225564 at SPATA13

1038 210827 s at ELF3 567 204588 s at SLC7A7 990 210095 s at IGFBP3

1403 217977 at MSRB1 1768 226051 at SELM 1224 213142 x at PION

1978 228824 s at PTGR1 93 200953 s at CCND2 1 190 212724 at RND3

1628 223463 at RAB23 2170 238513 at PRRG4 2163 238021 s at CRNDE

173 201563 at SORD 1607 223027 at SNX9 2005 229498 at MBNL3

430 203509 at SORL1 122 201 1 17 s at CPE 371 203002 at AMOTL2

1535 221538 s at PLXNA1 21 1 201848 s at BNI P3 1806 226517 at BCAT1

1868 227265 at FGL2 1527 221081 s at DENND2D 1208 213002 at MARCKS

322 202686 s at AXL 458 203761 at SLA 878 209120 at NR2F2

1077 21 1571 s at VCAN 1846 227027 at GFPT1 306 202551 s at CRIM1

320 202668 at EFNB2 1336 215071 s at HIST1 H2AC 597 204759 at RCBTB2

1920 227947 at PHACTR2 1720 225407 at MBP 1207 212998_x_at HLA-DQB1 /

1764 226021 at RDH10 1708 225262 at FOSL2 LOC100293977

296 202468 s at CTNNAL1 553 204446 s at ALOX5 1710 225282 at SMAP2

879 209121 x at NR2F2 1098 21 1742 s at EVI2B 226 201939 at PLK2

964 209823_x_at HLA-DQB1 /// 1684 224918 x at MGST1 335 202760_s_at AKAP2 /// PALM

LOC100293977 1622 223344 s at MS4A7 AKAP2

677 205479 s at PLAU 1 123 212012 at PXDN 1 149 212254_s_at DST /

310 202589 at TYMS 1086 21 1654 x at HLA-DQB1 LOC100652766

688 205573 s at SNX7 1263 213620 s at ICAM2 29 1555167 s at NAMPT

313 202620 s at PLOD2 1820 226695 at PRRX1 1084 21 1651 s at LAMB1

526 204204 at SLC31 A2 1365 216841_s_at LOC100129518 /// 436 203561 at FCGR2A

23 1554464_a_at CRTAP /// SOD2 1797 226337 at GORAB

LOC100653071 344 202833 s at SERPINA1 385 203108 at GPRC5A

1692 224996_at ASPH 1333 215034 s at TM4SF1 516 204141 at TUBB2A

355 202912 at ADM 1569 222108 at AMIG02 1675 224822 at DLC1

309 202581 at HSPA1 A /// HSPA1 B 1828 226790 at MORN2 268 202289 s at TACC2

814 207826 s at ID3 1583 222457 s at LIMA1 896 209212 s at KLF5

228 201951 at ALCAM 1491 219666 at MS4A6A 243 202073 at OPTN

517 204151 x at AKR1 C1 1613 223170 at TMEM98 1873 227314 at ITGA2

345 202859 x at IL8 1791 226279 at PRSS23 171 201540 at FHL1

1395 217890 s at PARVA 339 202786 at STK39 1264 213624 at SMPDL3A

926 209487 at RBPMS 298 202481 at DHRS3 1 19 201 109 s at THBS1

1746 225782 at MSRB3 1557 221872 at RARRES1 1624 223405 at NPL

2057 231577 s at GBP1 283 202375 at SEC24D 616 204924 at TLR2

887 209189 at FOS 1937 228155 at FAM213A 1824 226751 at CNRIP1

1439 218854 at DSE 1 193 212764 at ZEB1 2141 236140 at GCLM

580 204681 s at RAPGEF5 1427 218589 at LPAR6 17 1553976 a at DPCD

1849 227038 at SGMS2 1723 225481 at FRMD6 30 1555349 a at ITGB2

177 201579 at FAT1 489 203989 x at F2R 931 209539 at ARHGEF6

389 203148 s at TRIM14 1646 224159 x at TRIM4 290 202431 s at MYC

1 126 212062 at ATP9A 846 208798 x at GOLGA8A 1 139 212158 at SDC2

1 1 13 21 1953 s at IP05 126 201 147 s at TIMP3 429 203508 at TNFRSF1 B

1472 219410 at TMEM45A 183 201641 at BST2 490 204004 at PAWR

1837 226875 at DOCK1 1 1672 224799 at NDFI P2 152 201309 x at NREP

1721 225442 at DDR2 470 203854 at CFI 892 209201 x at CXCR4

706 205798 at IL7R 253 202157 s at CELF2 1520 220945 x at MANSC1

1549 221729 at COL5A2 27 1554899 s at FCER1 G 1900 227686 at OXNAD1

1620 223322 at RASSF5 1080 21 1597 s at HOPX 673 205419 at GPR183

1 168 212488 at COL5A1 1256 213539 at CD3D 497 204030_s_at IQCJ-SCHIP1 /

890 209199 s at MEF2C 1593 222750 s at SRD5A3 SCHIP1

249 2021 12 at VWF 1858 227184 at PTAFR 1462 219243 at GIMAP4

235 202007 at NID1 346 202869 at OAS1 533 204249 s at LM02

1823 226725 at 364 202949 s at FHL2 263 202269 x at GBP1

1 187 212690 at DDHD2 2037 230383 x at 34 1555579 s at PTPRM

97 200982 s at ANXA6 646 205159 at CSF2RB 1988 228964 at PRDM1

1936 228153 at RNF144B 802 207540 s at SYK 459 203765 at GCA

433 203535 at S100A9 121 201 1 16 s at CPE 360 202934 at HK2

895 20921 1 at KLF5 955 209771 x at CD24 750 206385 s at ANK3

1731 225613 at MAST4 627 204994 at MX2 2081 232231 at RUNX2

2237 39248 at AQP3 1444 218901 at PLSCR4 1285 213901 x at RBFOX2

1729 225589 at SH3RF1 1777 226120 at TTC8 352 202901 x at CTSS

1 173 212560 at SORL1 1205 212985 at APBB2 1556 221841 s at KLF4

573 204619 s at VCAN 2232 34210 at CD52 2245 57082 at LDLRAP1

1783 226218 at IL7R 2246 58780 s at ARHGEF40 1033 210762 s at DLC1

508 204083 s at TPM2 255 202202 s at LAMA4 927 209488 s at RBPMS

1377 217388 s at KYNU 1898 227647 at KCNE3 1547 221698 s at CLEC7A

222 201890 at RRM2 468 203828 s at IL32 1561 221935 s at EOGT

1621 223343 at MS4A7 1821 226697 at FAM1 14A1 2249 74694 s at RABEP2

187 201656 at ITGA6 2096 233955 x at CXXC5 1430 218694 at ARMCX1

1803 226459 at PIK3AP1 824 208158 s at OSBPL1 A 685 205552 s at OAS1

198 201714 at TUBG1 1366 216905 s at ST14 584 204688 at SGCE

474 203879 at PIK3CD 463 203789 s at SEMA3C 1759 225899_x_at FLJ45340 /

1418 218353 at RGS5 2092 232914 s at SYTL2 FLJ45445 /

1661 224663 s at CFL2 513 2041 18 at CD48 LOC100128326 /

280 202357 s at CFB 1276 213800 at CFH LOC100132050 /

509 204103 at CCL4 1 180 212606 at WDFY3 LOC 100287894 /

593 204747 at IFIT3 1081 21 1612 s at IL13RA1 LOC 100289306 /

1 199 212873 at HMHA1 1 132 212095 s at MTUS1 LOC 100506479 /

432 203528 at SEMA4D 464 203799_at CD302 /// LY75- LOC 100508632 /

1394 217867 x at BACE2 CD302 LOC 100652945 /

29074 at EHD4 LOC100653241 /

1630 223484 at C15orf48 1992 2

LOC 100653346 /

415 203404 at ARMCX2 1028 210664 s at TFPI

LOC729737

2003 229450 at IFIT3 1 103 21 1796 s at TRBC1

1 1 1553297 a at CSF3R

454 203735 x at PPFIBP1 1391 217838 s at EVL

502 204057 at IRF8

1571 222150 s at PION 1570 222146 s at TCF4

1437 218802 at CCDC109B

264 202270 at GBP1 839 208712 at CCND1

975 209933 s at CD300A

1467 219288 at C3orf14 1625 223422 s at ARHGAP24

377 203048 s at TTC37

127 201 149 s at TIMP3 21 13 235142 at ZBTB8A

1940 228176 at S1 PR3

871 209083 at COR01 A 1982 228863 at PCDH17

504 204059 s at ME1

379 203058 s at PAPSS2 1 108 21 1902 x at YME1 L1

408 203362 s at MAD2L1

347 202877 s at CD93 1260 213566 at RNASE6

598 204774 at EVI2A

640 2051 19 s at FPR1 221 1 242862 x at

391 203167 at TIMP2

1361 216379 x at CD24 451 203695 s at DFNA5

712 205859 at LY86

978 209955 s at FAP 793 207275 s at ACSL1

1690 224964 s at GNG2

946 209671 x at TRAC 1722 225464 at FRMD6

300 202499 s at SLC2A3

628 205003 at DOCK4 1802 226436 at RASSF4

1780 226185 at CDS1

1048 210904 s at IL13RA1 321 202672 s at ATF3

614 204912 at IL10RA

945 209670 at TRAC 368 202976 s at RHOBTB3

1 138 212148 at PBX1

476 203887 s at THBD 619 204949 at ICAM3

1681 224909 s at PREX1

815 207847 s at MUC1 566 204570 at COX7A1

366 202971 s at DYRK2

407 203355 s at PSD3 1738 225688 s at PHLDB2

1 145 212224 at ALDH1 A1

2229 31874 at GAS2L1 1408 218025 s at ECI2

641 205120 s at SGCB

1417 218330 s at NAV2 1573 222162 s at ADAMTS1

1290 213947 s at NUP210

937 209583 s at CD200 1022 210538 s at BI RC3

457 203760 s at SLA

935 209581 at PLA2G16 GIMAP5 1499 219777 at GIMAP6

631 205039 s at IKZF1 606 204834 at FGL2 307 202552 s at CRIM1

101 1 210425_x_at GOLGA8A /// 994 210136 at MBP 250 202132 at WWTR1

GOLGA8B /// 1085 21 1653_x_at AKR1 C2 /// 1261 213578 at BMPR1 A

LOC100508892 LOC100653286 231 201976 s at MYO10

1636 223640 at HCST 758 206481 s at LDB2 1441 218870 at ARHGAP15

2202 241681 at 1241 213392 at IQCK 175 201566 x at ID2

968 209879 at SELPLG 340 202796 at SYNPO 1400 217966 s at FAM129A

1258 213552 at GLCE 481 203923 s at CYBB 1245 213423 x at TUSC3

56 1558700 s at ZNF260 369 202990 at PYGL 1309 214414 x at HBA1 /// HBA2

444 203636 at MI DI 332 202747 s at ITM2A 1322 214617 at PRF1

806 207655 s at BLNK 413 203395 s at HES1 422 203470 s at PLEK

354 202910 s at CD97 1 18 201 108 s at THBS1 1262 213618 at ARAP2

1855 227134 at SYTL1 578 204674 at LRMP 491 204005 s at PAWR

1055 210992 x at FCGR2C 2002 229434 at 956 209772 s at CD24

1051 210972_x_at TRAC /// TRAJ17 /// 434 203543 s at KLF9 1321 214581 x at TNFRSF21

TRAV20 1834 226841 at MPEG1 1363 216598 s at CCL2

506 204070 at RARRES3 1 177 212590 at RRAS2 312 202619 s at PLOD2

24 1554544 a at MBP 1667 224724 at SULF2 1550 221730 at COL5A2

1831 226818 at MPEG1 898 209228 x at TUSC3 342 202806 at DBN1

394 203185 at RASSF2 1637 223681 s at INADL 1271 213733 at MY01 F

2039 230391 at CD84 446 203642 s at COBLL1 922 209406 at BAG2

33 1555564 a at CFI 1597 222838 at SLAMF7 1951 228333 at ZEB2

1020 210517 s at AKAP12 729 206099 at PRKCH 1501 219787 s at ECT2

1559 221884 at MECOM 1453 219073 s at OSBPL10 406 203325 s at COL5A1

1529 221210 s at NPL 1359 216033 s at FYN 1767 226039 at MGAT4A

920 209395 at CHI3L1 1632 223502 s at TNFSF13B 639 2051 14_s_at CCL3 /// CCL3L1 /

1617 223279 s at UACA 372 203021 at SLPI CCL3L3

262 202260 s at STXBP1 299 202489 s at FXYD3 1310 214439 x at BIN1

1455 219134 at ELTD1 49 155741 1 s at SLC25A43 1 148 212233 at MAPI B

1 1 1 201042 at TGM2 1921 227948 at FGD4 1787 226244 at CLEC14A

247 202086 at MX1 1255 213537 at HLA-DPA1 1503 219799 s at DHRS9

1890 227542 at SOCS6 1213 213032 at NFIB 2122 235391 at FAM92A1

710 205831 at CD2 404 203323 at CAV2 1651 224435 at FAM213A

531 204236 at FLU 1 172 212538 at DOCK9 1716 225373 at C10orf54

1024 210609 s at TP53I3 330 202743 at PIK3R3 1036 210785 s at C1 orf38

1349 215446 s at LOX 1998 229367 s at GIMAP6 1655 224516 s at CXXC5

1724 225496 s at SYTL2 1018 21051 1 s at INHBA 452 203708 at PDE4B

1320 214574 x at LST1 1648 224352 s at CFL2 647 205171 at PTPN4

1438 218805 at GIMAP1 -GIMAP5 /// 636 205098 at CCR1 1771 226068 at SYK

1461 21921 1 at USP18 862 208965 s at I FI16 LOC728875

1946 228284 at TLE1 1025 210629 x at LST1 1682 22491 1 s at DCBLD2

1685 224925 at PREX1 438 203570 at LOXL1 1749 225806 at AJUBA

435 203560 at GGH 949 209699_x_at AKR1 C2 /// 1448 218986 s at DDX60

1200 212912 at RPS6KA2 LOC100653286 1889 227530 at AKAP12

1773 226084 at MAPI B 877 2091 14 at TSPAN1 543 204352 at TRAF5

1537 221558 s at LEF1 1443 218885 s at GALNT12 2 1405 i at CCL5

532 204237 at GULP1 1 156 212354 at SULF1 1784 226219 at ARHGAP30

398 203213 at CDK1 659 205270 s at LCP2 1838 226876 at FAM101 B

1796 226333 at IL6R 1458 219191 s at BIN2 1351 215633 x at LST1

1827 226789 at EMB 1078 21 1581 x at LST1 1069 21 1395 x at FCGR2C

932 209550 at NDN 1 142 212190 at SERPINE2 1893 227607 at STAMBPL1

1962 228532 at C1 orf162 687 205569 at LAMP3 2027 230180 at DDX17

1916 227856 at C4orf32 2088 232615 at 1591 222693 at FNDC3B

891 209200 at MEF2C 220 201888 s at IL13RA1 1314 214464 at CDC42BPA

479 203910 at ARHGAP29 1634 223562 at PARVG 2029 230250 at PTPRB

658 205269 at LCP2 2135 235879 at 294 202454 s at ERBB3

1790 226275 at MXD1 622 204959 at MNDA 149 201292 at TOP2A

1405 217996 at PHLDA1 1243 213416 at ITGA4 1027 210663 s at KYNU

1 169 212489 at COL5A1 1933 228094 at AMICA1 1755 225847 at NCEH1

362 202946 s at BTBD3 1299 214181 x at LST1 465 203810 at DNAJB4

62 1565162 s at MGST1 1612 223125 s at C1 orf21 1902 227692 at GNAI1

1753 225842 at PHLDA1 336 202761 s at SYNE2 2218 243296 at NAMPT

961 209803 s at PHLDA2 167 201468 s at NQ01 367 202975 s at RHOBTB3

1752 225835 at SLC12A2 499 204036 at LPAR1 1976 228771 at ADRBK2

791 207238 s at PTPRC 2074 232024 at GIMAP2 1818 226682 at RORA

1974 228762 at LFNG 477 203892 at WFDC2 1980 228846 at MXD1

1863 227223 at RBM39 1766 226028 at ROB04 304 202524 s at SPOCK2

1 162 212414 s at GLYR1 /// SEPT6 1740 225701 at AKNA 582 204683 at ICAM2

649 205180 s at ADAM8 1734 225664 at COL12A1 357 202931 x at BIN1

2236 38149 at ARHGAP25 317 202628 s at SERPINE1 1695 225018 at SPIRE1

473 203875 at SMARCA1 689 205590 at RASGRP1 1332 215017 s at FNBP1 L

803 207571 x at C1 orf38 1867 227261 at KLF12 799 207480 s at MEIS2

216 201860 s at PLAT 2214 242907 at GBP2 695 205668 at LY75

1460 219209 at IFIH1 1826 226757 at I FIT2 904 209291 at ID4

505 204066 s at AGAP1 1912 22781 1 at FGD3 672 205407 at RECK

977 209949 at NCF2 753 206414 s at ASAP2 1083 21 1645 x at

575 204655 at CCL5 1215 213056 at FRMD4B 560 204502 at SAMHD1

1066 21 1340 s at MCAM 1882 227384 s at LOC727820 /// 1707 225242 s at CCDC80

1518 220330 s at SAMSN1 LOC728855 /// 1223 213139 at SNAI2

2106 234986 at GCLM 20 1554018 at GPNMB 350 202897 at SIRPA

2187 239629 at CFLAR 1847 227030 at IKZF3 1899 227677 at JAK3

1872 227295 at IKBI P 337 202765 s at FBN1 2156 236841 at LOC100134445

308 202554 s at GSTM3 1953 228339 at ECSCR 886 209173 at AGR2

2184 239294 at 1 155 212353 at SULF1 637 205099 s at CCR1

893 209209 s at FERMT2 1292 213998 s at DDX17 1214 213036 x at ATP2A3

747 206363 at MAF 751 206392 s at RARRES1 925 209485 s at OSBPL1 A

726 206059 at ZNF91 37 1555745 a at LYZ 1932 228071 at GIMAP7

704 205786 s at ITGAM 794 207339 s at LTB 1327 214724 at DIXDC1

635 205081 at CRIP1 1949 228314 at LRRC8C 601 204790 at SMAD7

1 124 212013 at PXDN 1242 213397 x at RNASE4 1725 225502 at DOCK8

303 202510 s at TNFAI P2 390 203153 at I FIT1 782 206953 s at LPHN2

1428 218638_s_at LOC100130872 /// 1985 228904 at HOXB3 448 203650 at PROCR

SPON2 8 1553043 a at CD300LF 885 209160 at AKR1 C3

881 209129 at TRI P6 564 204533 at CXCL10 1590 222686 s at CPPED1

860 208937 s at ID1 1485 219563 at LINC00341 2167 238327 at ODF3B

1 137 212143 s at IGFBP3 1595 222830 at GRHL1 943 209655 s at TMEM47

1 191 212750 at PPP1 R16B 929 209505 at NR2F1 384 203088 at FBLN5

61 1 204882 at ARHGAP25 1839 226878 at HLA-DOA 970 209890 at TSPAN5

939 209606 at CYTI P 1315 214467 at GPR65 1 154 212344 at SULF1

1089 21 1661 x at PTAFR 437 203562 at FEZ1 1046 210895 s at CD86

1986 228949 at WLS 292 202436 s at CYP1 B1 775 206765 at KCNJ2

1631 223501 at TNFSF13B 1694 225008 at ASPH 1010 210423 s at SLC1 1 A1

1562 221958 s at WLS 1844 226991 at NFATC2 969 209881 s at LAT

625 204971 at CSTA 1999 229383 at MARCH1 1222 213135 at TIAM1

1699 225105 at C12orf75 664 205291 at IL2RB 1805 226490 at NHSL1

1878 227354 at PAG1 518 204153 s at MFNG 2056 231274 s at

1525 221024 s at SLC2A10 1313 214456 x at SAA1 /// SAA2 410 203386 at TBC1 D4

2017 229910 at SHE 1239 213375 s at N4BP2L1 1234 213309 at PLCL2

669 205382 s at CFD 1541 221584 s at KCNMA1 275 202341 s at TRIM2

2015 229723 at TAGAP 498 204032 at BCAR3 1864 227232 at EVL

1876 227346 at IKZF1 1977 228776 at GJC1 1747 225786 at HNRNPU-AS1

1014 210448 s at P2RX5 396 203196 at ABCC4 2000 229390 at FAM26F

1253 213524 s at G0S2 1870 227289 at PCDH17 1956 228372 at C10orf128

7 1552807 a at SIGLEC10 1079 21 1582 x at LST1 620 204951 at RHOH

722 205990 s at WNT5A 1225 213160 at DOCK2 1516 220088 at C5AR1

2068 231873 at BMPR2 828 208438 s at FGR 1896 227645 at PIK3R5

820 208018 s at HCK 732 206150 at CD27 823 208146 s at CPVL

1942 228256 s at EPB41 L4A 1368 216950_s_at FCGR1 A /// FCGR1 B 1 179 212599 at AUTS2

316 202627 s at SERPINE1 /// FCGR1 C 642 205128 x at PTGS1

1043 210869 s at MCAM 1015 210473 s at GPR125 1459 219201 s at TWSG1

1798 226364 at HIP1 1560 22191 1 at ETV1 1204 212977 at CXCR7

915 209373 at MALL 1567 222062 at IL27RA 1244 213418 at HSPA6

798 207469 s at PIR 503 204058 at ME1 494 20401 1 at SPRY2

653 205220 at HCAR3 1450 218995 s at EDN1 1574 222218 s at PILRA

1800 226420 at MECOM 148 201291 s at TOP2A 844 208791 at CLU

613 204891 s at LCK 2105 234970 at TC2N 1815 226659 at DEF6

370 202998 s at LOXL2 787 207085 x at CSF2RA 579 204677 at CDH5

612 204890 s at LCK 1564 222016 s at ZNF323 2136 235919 at CEP78

1540 221581 s at LAT2 1887 227481 at CNKSR3 442 203603 s at ZEB2

1 102 21 1795 s at FYB 984 210029 at I D01 728 206082 at HCP5

293 202437 s at CYP1 B1 1354 215785 s at CYFIP2 2080 232213 at PELI1

1281 213844 at HOXA5 2130 235651 at TTC22 1001 210176 at TLR1

1948 228298 at PCED1 B 1877 227353 at TMC8 493 204007 at FCGR3B

1266 213668 s at SOX4 1600 222877 at 2142 236179 at CDH1 1

1545 221667 s at HSPB8 69 200606 at DSP 702 205758 at CD8A

1606 222934 s at CLEC4E 648 205174 s at QPCT 934 209576 at GNAI1

623 204960 at PTPRCAP 245 202083 s at SEC14L1 1270 213725 x at XYLT1

403 203305 at F13A1 796 207419 s at RAC2 1822 226702 at CMPK2

41 1 203387 s at TBC1 D4 996 210140 at CST7 1757 225883 at ATG16L2

958 209791 at PADI2 131 1 214453 s at I FI44 565 204563 at SELL

1644 224002 s at FKBP7 525 204201 s at PTPN13 921 209396 s at CHI3L1

1959 228423 at MAP9 325 202718 at IGFBP2 121 1 213010 at PRKCDBP

1237 213342 at YAP1 158 201387 s at UCHL1 276 202342 s at TRIM2

605 204825 at MELK 1851 227070 at GLT8D2 21 19 235306 at GIMAP8

938 209604 s at GATA3 707 205804 s at TRAF3IP3 1857 227152 at C12orf35

1814 226641 at ANKRD44 1907 227780 s at ECSCR 54 1558508 a at C1 orf53

982 210026 s at CARD10 1466 219279 at DOCK10 999 210164 at GZMB

905 209298 s at ITSN1 472 203874 s at SMARCA1 2076 232080 at HECW2

1598 222858 s at DAPP1 1209 213005 s at KANK1 1002 210184 at ITGAX

954 209765 at ADAM19 1045 210889 s at FCGR2B 1582 222455 s at PARVA

657 205267 at POU2AF1 2046 230805 at 615 204923 at SASH3

989 210089 s at LAMA4 1090 21 1668 s at PLAU 423 203471 s at PLEK

507 204072 s at FRY 1943 228258 at TBC1 D10C 838 20871 1 s at CCND1

1058 21 1071 s at MLLT1 1 1781 226189 at ITGB8 1445 218918 at MAN1 C1

698 205681 at BCL2A1 1883 227399 at VGLL3 1074 21 1506 s at IL8

1465 219274 at TSPAN12 1596 222834 s at GNG12 36 1555638 a at SAMSN1

2108 234994 at TMEM200A 1318 214549 x at SPRR1 A 1558 221879 at CALML4

2072 231947 at MYCT1 923 209447 at SYNE1 254 202196 s at DKK3

2188 239744 at — 1966 228624 at TMEM144 1248 213429 at BICC1

2176 238669 at PTGS1 583 204686 at I RS1 523 204197 s at RUNX3

418 203424 s at IGFBP5 1979 228827 at RUNX1 T1 1021 210519 s at NQ01

1 163 212415 at SEPT6 1470 219352 at HERC6 651 205194 at PSPH

1543 221602 s at FAIM3 1534 221491_x_at HLA-DRB1 /// HLA- 772 206707 x at FAM65B

1526 221080 s at DENND1 C DRB3 /// HLA-DRB4 974 209921 at SLC7A1 1

201 1 229597 s at WDFY4 /// HLA-DRB5 /// 1810 226576 at ARHGAP26

1938 228157 at ZNF207 LOC 100507709 /// 1888 227484 at SRGAP1

1 171 212531 at LCN2 LOC100507714 /// 1283 213888 s at TRAF3I P3

644 205147 x at NCF4 LOC100509582 535 204268 at S100A2

55 1558662 s at BANK1 2228 266 s at CD24 2197 240830 at SCARNA17

2175 238668 at 1 183 212657 s at IL1 RN 654 205234 at SLC16A4

1250 213475 s at ITGAL 678 205488 at GZMA 675 205466 s at HS3ST1

1693 224999 at EGFR 766 206637 at P2RY14 52 15581 1 1 at MBNL1

26 1554741_s_at FGF7 /// KGFLP1 /// 2201 241435 at 445 203637 s at MI DI

KGFLP2 1769 226064 s at DGAT2 544 204359_at FLRT2 /

2051 231 124 x at LY9 1987 228950 s at WLS LOC100506718

1891 227554 at MAGI2-AS3 184 201645 at TNC 1220 213106 at ATP8A1

1652 224451 x at ARHGAP9 522 204192 at CD37 10 1553132 a at TC2N

1874 227344 at IKZF1 2124 235458 at HAVCR2 2213 242903 at IFNGR1

957 209774 x at CXCL2 1486 219569 s at SLC35G2 1750 225812 at C6orf225

602 204794 at DUSP2 1809 226548 at SBK1 1619 223315 at NTN4

790 207224 s at SIGLEC7 51 1 2041 14 at NI D2 808 207697 x at LILRB2

2250 91816 f at MEX3D 1897 227646 at EBF1 41 1555852 at LOC100507463

1548 221724 s at CLEC4A 469 203851 at IGFBP6 1929 228055 at NAPSB

2070 231929 at IKZF2 868 209016 s at KRT7 13 1553613 s at FOXC1

2012 229625 at GBP5 1808 226545 at CD109 833 208651 x at CD24

845 208792 s at CLU 232 201983 s at EGFR 1881 227383 at LOC727820

1 1 17 at HSPA6 948 209685 s at PRKCB 541 204337 at RGS4

1604 222895 s at BCL1 1 B 1356 215813 s at PTGS1 652 205207 at IL6

2164 238063 at TMEM154 1429 218651 s at LARP6 420 203435 s at MME

1317 21451 1 x at FCGR1 B 723 205997 at ADAM28 548 204400 at EFS

542 204351 at S100P 1435 218736 s at PALMD 1869 227266 s at FYB

43 1555962 at B3GNT7 530 204235 s at GULP1 604 204823 at NAV3

1894 227623 at CACNA2D1 1973 228748 at CD59 2165 238066 at RBP7

1088 21 1657 at CEACAM6 166 201467 s at NQ01 1254 213534 s at PASK

1761 225946 at RASSF8 424 203474 at IQGAP2 302 202504 at TRIM29

1852 227080 at ZNF697 621 204955 at SRPX 705 205790 at SKAP1

460 203767 s at STS 2030 230263 s at DOCK5 1007 210347 s at BCL1 1 A

2109 235023 at VPS13C 965 209827 s at IL16 1884 227410 at FAM43A

2195 240572 s at LOC374443 1910 227799 at MYQ1 G 2052 231 130 at FKBP7

1231 213249 at FBXL7 1057 21 1005 at LAT 603 204797 s at EML1

57 1558747 at SMCHD1 1993 229218 at COL1 A2 629 205005 s at NMT2

22 1554406 a at CLEC7A 4 1552316 a at GIMAP1 1279 213830 at YME1 L1

252 202156 s at CELF2 1918 227889 at LPCAT2 778 206805 at SEMA3A

44 1555963 x at B3GNT7 1064 21 1 178 s at PSTPIP1 439 203571 s at C10orf1 16

1895 227628 at GPX8 568 204595 s at STC1 1892 227566_at LOC100653217 /

1246 213425 at WNT5A 1463 219256 s at SH3TC1 NTM

2032 230270 at PRPF38B 786 207072 at IL18RAP 1623 223395 at ABI3BP

2219 243395 at 2067 231776 at EOMES 1474 219434 at TREM1

2157 236907 at 2137 235944 at HMCN1 1990 229041 s at LOC100505746

1233 213262 at SACS 633 205049 s at CD79A 1 167 212486 s at FYN

449 203685 at BCL2 985 210031 at CD247 1289 213931 at ID2 /// ID2B

1842 226908 at LRIG3 976 209946 at VEGFC 1358 215933 s at HHEX

2179 238756 at GAS2L3 1374 217143 s at YME1 L1 416 203413_at LOC100653018 /

2220 243489 at 1372 217078 s at CD300A LOC 100653255 /

928 209498 at CEACAM1 349 202888 s at ANPEP NELL2

392 203180 at ALDH1 A3 914 209369 at ANXA3 832 208650 s at CD24

2062 231729 s at CAPS 1594 222802 at EDN1 2086 232543 x at ARHGAP9

550 20441 1 at KIF21 B 1960 228442 at NFATC2 1705 225207 at PDK4

1442 218876 at TPPP3 2014 229686 at P2RY8 2150 236379 at

807 207677 s at NCF4 1994 229225 at NRP2 1476 219471 at KIAA0226L

1226 213170 at GPX7 1913 227812 at TNFRSF19 1505 219892 at TM6SF1

2126 235518 at SLC8A1 694 205639 at AOAH 1968 228640 at PCDH7

1451 219014 at PLAC8 1296 214084 x at NCF1 C 783 206978 at CCR2

1727 225548 at SHROOM3 1508 219947 at CLEC4A 600 204779 s at HOXB7

210 201843 s at EFEMP1 2036 230378 at SCGB3A1 2053 231 166 at GPR155

21 10 235046 at INPP4B 1860 227196 at RHPN2 2025 230175 s at DCBLD2

1983 228865 at C1 orf1 16 591 204734 at KRT15 1316 214470 at KLRB1

1626 223434 at GBP3 492 204006 s at FCGR3A /// FCGR3B 830 208607_s_at SAA1 /// SAA2 /

1799 226380 at PTPN21 21 17 235199 at RNF125 SAA2-SAA4

686 205568 at AQP9 1067 21 1343 s at COL13A1 769 206666 at GZMK

1380 217502 at IFIT2 624 204961 _s_at NCF1 /// NCF1 B /// 2242 41577 at PPP1 R16B

953 209728_at HLA-DRB4 /// NCF1 C 1504 219812 at PVRIG

LOC100509582 1930 228063 s at NAP1 L5 2041 230494 at SLC20A1

1288 213915 at NKG7 2094 233555 s at SULF2 936 209582 s at CD200

2207 242352 at NIPBL 3 1552315 at GIMAP1 2162 238017 at SDR16C5

15 1553681 a at PRF1 692 205618 at PRRG1 2043 230707 at SORL1

1542 221601 s at FAIM3 2083 232304 at PELI 1 1487 219574 at MARCH1

431 203510 at MET 1744 225763 at RCSD1 1252 213506 at F2RL1

2210 242814 at SERPINB9 2038 230389 at FNBP1 2172 238558 at

1 101 21 1794 at FYB 1075 21 1538 s at HSPA2 1217 213093 at PRKCA

773 206710 s at EPB41 L3 1042 210847 x at TNFRSF25 1714 225342_at AK4 /

2018 229937 x at 1788 226267 at JDP2 LOC100507855

1278 213817 at IRAK3 318 202663 at WIPF1 2008 229560 at TLR8

1795 226322 at TMTC1 724 206025 s at TNFAIP6 2028 230245 s at LOC283663

674 205422 s at ITGBL1 771 206702 at TEK 2010 229584 at LRRK2

1 186 212681 at EPB41 L3 1914 227828 s at FAM176A 1762 225987 at STEAP4

2091 232843 s at DOCK8 1 153 212338 at MY01 D 59 1559425 at

2247 64408 s at CALML4 480 203922 s at CYBB 708 205821_at KLRC4-KLRK1 /

765 206632 s at APOBEC3B 1770 226067 at BPI FB1 KLRK1

21 15 235146 at TMCC3 557 204470 at CXCL1 1 100 21 1776 s at EPB41 L3

1076 21 1564 s at PDLIM4 1369 216973 s at HOXB7 32 1555497 a at CYP4B1

2182 239135 at CPPED1 1275 213797 at RSAD2 2044 230741 at

2001 229391 s at FAM26F 1345 215294 s at SMARCA1 1495 219684 at RTP4

638 205101 at CIITA 441 203591 s at CSF3R 563 204529 s at TOX

1587 222549 at CLDN1 812 207795 s at KLRD1 1367 216920 s at TARP /// TRGC2

1751 225817 at CGNL1 1533 221261_x_at MAGED4 /// 1599 222859 s at DAPP1

1565 222040 at HNRNPA1 MAGED4B /// 60 1559584 a at C16orf54

718 205922 at VNN2 SNORA1 1 D /// 1616 223278 at GJB2

2026 230179 at LOC285812 SNORA1 1 E 1035 210772 at FPR2

2226 244313 at CR1 1206 212992 at AHNAK2 1416 218326 s at LGR4

2013 229670 at 1939 228167 at KLHL6 960 209795 at CD69

585 204689 at HHEX 1257 213541 s at ERG 1023 210606 x at KLRD1

1984 228869 at SNX20 1478 219479 at KDELC1 590 204731 at TGFBR3

1539 221577 x at GDF15 1813 226622 at MUC20 730 2061 1 1 at RNASE2

31 1555355 a at ETS1 2215 242946 at CD53 421 203440 at CDH2

1647 224341 x at TLR4 683 205542 at STEAP1 1934 228128 x at PAPPA

587 204702 s at NFE2L3 1337 215073 s at NR2F2 1843 226960 at CXCL17

2042 230550 at MS4A6A 1346 215342 s at RABGAP1 L 2099 234151 at

1490 219637 at ARMC9 2131 235670 at STX1 1 1601 222885 at EMCN

278 202350_s_at LOC 100506558 /// 485 203939 at NT5E 16 1553764 a at AJUBA

MATN2 754 206420 at IGSF6 1006 210321 at GZMH

1961 228471 at ANKRD44 715 205896 at SLC22A4 21 12 235086 at THBS1

1515 220066 at NOD2 2104 234949 at FRG1 B 1957 228390 at RAB30

596 204751 x at DSC2 1955 228365 at CPNE8 2148 236295 s at MI R3929 /// NLRC3

1775 226103 at NEXN 500 204042 at WASF3 680 205499 at SRPX2

331 202746 at ITM2A 650 205185 at SPINK5 1293 214032 at ZAP70

524 204198 s at RUNX3 1406 217997 at PHLDA1 2233 35974 at LRMP

1919 227929 at LIN7A 2205 242146 at SNRPA1 1307 214366 s at ALOX5

630 205006 s at NMT2 206 201820 at KRT5 1964 228585 at ENTPD1

1528 221 122 at HRASLS2 238 202018 s at LTF 1935 228141 at GPX8

1201 212942 s at KIAA1 199 2146 236280 at 475 203881 s at DMD

53 1558397 at PECAM1 693 205627 at CDA 795 207387 s at GK

1862 227210 at SFMBT2 1229 213240 s at KRT4 1850 227051 at

986 210038 at PRKCQ 679 205495 s at GNLY 759 206488 s at CD36

752 206398 s at CD19 1065 21 1339 s at ITK 1473 219423 x at TNFRSF25

725 206026 s at TNFAI P6 2168 238429 at TMEM71 427 203499 at EPHA2

719 205936 s at HK3 456 203757 s at CEACAM6 1563 221969 at PAX5

1588 222608 s at ANLN 1282 213865 at DCBLD2 402 203290 at HLA-DQA1

997 210145 at PLA2G4A 1643 223952 x at DHRS9 1457 219179 at DACT1

981 210002 at GATA6 1060 21 1 138 s at KMO 599 204777 s at MAL

804 207610 s at EMR2 1061 21 1 144 x at TARP /// TRGC2 610 204860_s_at LOC 100509323 /

1785 226225 at MCC 962 209813 x at TARP NAIP

61 1563674 at FCRL2 571 204612 at PKIA 745 206337 at CCR7

760 206513 at AIM2 2203 242008 at 1481 219498 s at BCL1 1 A

58 1559156 at 1355 215806 x at TARP /// TRGC2 2128 235567 at RORA

1633 223553 s at DOK3 671 205406 s at SPA17 1605 222915 s at BANK1

2180 238778 at MPP7 1236 213338 at TMEM158 2225 244023 at SYK

1832 226834 at 2227 244654 at MY01 G 1489 219630 at PDZK1 IP1

2149 236297 at 2198 240890 at LOC643733 1879 227361 at HS3ST3B1

409 203372 s at SOCS2 1210 213006 at CEBPD 2055 231227 at WNT5A

777 206804 at CD3G 2035 230372 at HAS2 1915 227850 x at CDC42EP5

521 204187 at GMPR 670 205403 at IL1 R2 1970 228661_s_at LOC 100506029 /

21 1554240 a at ITGAL 764 206631 at PTGER2 LOC100506051

2065 231747 at CYSLTR1 1273 213791 at PENK 1635 223631 s at C19orf33

800 207509 s at LAIR2 588 204714 s at F5 2079 232210 at

1971 228698 at SOX7 2241 41469 at PI3 740 206271 at TLR3

1519 220542 s at BPIFA1 959 209792 s at KLK10 1357 215925 s at CD72

645 205157 s at JUP /// KRT17 1609 223062 s at PSAT1 1639 223748 at SLC4A1 1

2098 234032 at 1097 21 1737_x_at LOC 100287705 /// 1592 222717 at SDPR

1991 229072 at RAB30 PTN 1454 219093 at PID1

1931 228067 at C2orf55 21 18 235213 at ITPKB 2019 229952 at

239 202037 s at SFRP1 547 204393 s at ACPP 1475 219452 at DPEP2

2154 236565 s at LARP6 662 205289 at BMP2 720 205945 at IL6R

2186 239597 at 1 189 212706 at RASA4 /// RASA4B 2145 236262 at MMRN2

555 204466 s at SNCA 1381 217523 at CD44 2217 243154 at

696 205671 s at HLA-DOB 2235 37145 at GNLY 665 205306 x at KMO

661 205285 s at FYB 1512 220005 at P2RY13 2050 231093 at FCRL3

291 202435 s at CYP1 B1 1009 210413_x_at SERPINB3 /// 1287 213906 at MYBL1

676 205476 at CCL20 SERPINB4 2153 236539 at PTPN22

1328 214735 at IPCEF1 1645 224009 x at DHRS9 762 206561 s at AKR1 B10

2199 241068 at 1969 228658 at Ml AT 784 207008 at CXCR2

700 205715 at BST1 2040 230464 at S1 PR5 1954 228347 at SIX1

2084 232431 at NR3C1 816 207850 at CXCL3 608 204846 at CP

2132 235735 at TNFSF8 1005 210299 s at FHL1 1653 224463 s at C1 1 orf70

2209 242695 at 1238 213355 at ST3GAL6 668 205381 at LRRC17

2171 238542 at ULBP2 272 20231 1 s at COL1 A1 2123 235421 at MAP3K8

1717 225381 at MI R100HG 829 208450 at LGALS2 2073 232001 at LOC439949

537 204298 s at LOX 1029 210665 at TFPI 817 207857 at LILRA2

774 206761 at CD96 1483 219528 s at BCL1 1 B 709 205828 at MMP3

666 205316 at SLC15A2 2120 235318 at FBN1 281 202363 at SPOCK1

805 207651 at GPR171 655 205237 at FCN1 1407 217999 s at PHLDA1

2134 235740 at MCTP1 1383 217678 at SLC7A1 1 2143 236193 at HIST1 H2BC

2248 64900 at TMEM231 1500 219778 at ZFPM2 2174 238623 at

450 203691 at PI3 2224 244008 at PARP8 738 206197 at NME5

737 206176 at BMP6 1 196 212827 at IGHM 1218 213094 at GPR126

801 207522 s at ATP2A3 81 1 207777 s at SP140 1817 226677 at ZNF521

9 1553105 s at DSG2 1875 227345 at TNFRSF10D 714 205883 at ZBTB16

534 204256 at ELOVL6 2045 230746 s at 1584 222486 s at ADAMTS1

748 206366 x at XCL1 1016 210479 s at RORA 2185 239587 at

2194 240304 s at TMC5 1995 229228_at CREB5 /// 2087 232614 at

690 205597 at SLC44A4 LOC401317 1654 224480 s at AGPAT9

1523 220999 s at CYFI P2 951 209719 x at SERPINB3 19 1553995 a at NT5E

1989 229012 at C9orf24 1566 222043 at CLU 1319 214567 s at XCL1 /// XCL2

1 161 212413 at SEPT6 880 209125 at KRT6A 1000 210172 at SF1

1772 226069 at PRICKLE1 1531 221239 s at FCRL2 2181 238846 at TNFRSF1 1 A

663 205290 s at BMP2 1267 213674 x at IGHD 2022 230093 at RSPH1

1068 21 1372 s at IL1 R2 971 209900 s at SLC16A1 1885 227449 at EPHA4

48 1557080 s at ITGBL1 51 1557718 at PPP2R5C 2033 230323 s at TMEM45B

443 203608 at ALDH5A1 1494 219682 s at TBX3 1886 227475 at FOXQ1

819 207957 s at PRKCB 218 201884 at CEACAM5 1778 226147 s at PIGR

2223 243780 at 966 209829 at FAM65B 1422 218469 at GREM1

1510 219985 at HS3ST3A1 1221 2131 10 s at COL4A5 780 206914 at CRTAM

1456 219159 s at SLAMF7 1378 217418 x at MS4A1 1 197 212843 at NCAM1

788 2071 1 1 at EMR1 478 203908 at SLC4A4 2139 236085 at CAPSL

1 105 21 1828 s at TNIK 1497 219734 at SI DT1 1008 210356 x at MS4A1

727 206060 s at PTPN22 2151 236439 at 552 204439 at IFI44L

2125 235489 at RHOJ 1012 210426 x at RORA 2147 236293 at RHOH

1265 213664 at SLC1 A1 1044 210873 x at APOBEC3A 1004 210297 s at MSMB

1589 222668 at KCTD15 1484 219529 at CLIC3 716 205898 at CX3CR1

713 205863 at S100A12 1735 225667 s at FAM84A 757 206464 at BMX

1449 218990 s at SPRR3 2021 230061 at TM4SF18 1096 21 1734 s at FCER1 A

21 16 235171 at LOC100505501 617 204932 at TNFRSF1 1 B 466 203820 s at IGF2BP3

1480 219497 s at BCL1 1 A 536 204273 at EDNRB 1447 218963 s at KRT23

2006 229513 at STRBP 2212 242871 at PAQR5 1941 228241 at AGR3

2077 232082 x at SPRR3 1816 226676 at ZNF521 2216 243109 at MCTP2

1302 214240 at GAL 701 205725 at SCGB1 A1 667 205319 at PSCA

2177 238689 at GPR1 10 1963 228575 at IL20RB 2093 233364 s at

889 209198 s at SYT1 1 1350 215506 s at DI RAS3 901 209278 s at TFPI2

2238 39549 at NPAS2 1277 213802 at PRSS12 933 209555 s at CD36

1312 214455_at HIST1 H2BC /// 993 2101 19 at KCNJ15 721 205979 at SCGB2A1

HIST1 H2BE /// 2155 236656 s at LOC10028891 1 419 203434 s at MME

HIST1 H2BF /// 1901 227688 at LRCH2 1063 21 1 163 s at TNFRSF10C HIST1 H2BG /// 361 202935 s at SOX9 1059 21 1 122 s at CXCL1 1 HIST1 H2BI 2078 2321 13 at 1421 218468 s at GREM1

973 209905_at HOXA10-HOXA9 /// 2196 240665 at 1496 219727 at DUOX2

HOXA9 1917 227875 at KLHL13 660 205280 at GLRB

1530 221234 s at BACH2 71 1 205844 at VNN1 1996 229331 at SPATA18

1268 213680 at KRT6B 1477 219476 at C1 orf1 16 987 210064 s at UPK1 B

2049 231077 at C1 orf192 2221 243509 at 1308 214370 at S100A8

2140 236129 at GALNT5 1944 228266 s at HDGFRP3 1514 220059 at STAP1

595 204750 s at DSC2 1905 227725 at ST6GALNAC1 1967 228635 at PCDH10

2208 242625 at RSAD2 1926 228033 at E2F7 2173 238581 at GBP5

1638 223734 at MGARP 5 1552365 at SCIN 2066 231766 s at COL12A1

1492 219667 s at BANK1 1304 214321 at NOV 2082 232235 at DSEL

2129 235629 at 1330 214974 x at CXCL5 191 1 227803 at ENPP5

1742 225728 at SORBS2 900 209277 at TFPI2 1906 227769 at GPR27

2200 241412 at BTC 594 204748 at PTGS2 2190 240061 at

1502 219795 at SLC6A14 1865 227238 at MUC15 768 206643 at HAL

2178 238720 at LOC100506582 741 206307 s at FOXD1 930 209529 at PPAP2C

18 1553994 at NT5E 495 204014 at DUSP4 2166 2381 16 at DYNLRB2

546 204379 s at FGFR3 755 206432 at HAS2 2023 230135 at HHIP

691 205609 at ANGPT1 656 205239 at AREG /// AREGB 1975 228766 at CD36

1235 213325 at PVRL3 1650 224367 at BEX2 963 209821 at IL33

21 14 235144 at RASEF 682 205532 s at CDH6 746 206343 s at NRG1

426 203485 at RTN1 1687 224940 s at PAPPA 776 206785 s at KLRC1 /// KLRC2

1469 219304 s at PDGFD 2158 237009 at 570 204602 at DKK1

1488 219580 s at TMC5 2059 231597 x at 2048 230970 at

2204 242093 at SYTL5 1300 214183 s at TKTL1 1854 227123 at RAB3B

2243 44790 s at KIAA0226L 1688 224941 at PAPPA 1866 227241 at MUC15

821 208025 s at HMGA2 761 206515 at CYP4F3 1464 219263 at RNF128

739 206207 at CLC 717 205899 at CCNA1 2075 232056 at SCEL

609 204855 at SERPINB5 618 204933 s at TNFRSF1 1 B 2191 240065 at FAM81 B

736 206172 at IL13RA2 1952 228335 at CLDN1 1 2192 240161 s at CDC20B

2159 237466 s at HHIP 2189 239893 at 1835 226847 at FST

2071 231941 s at MUC20 556 204469 at PTPRZ1 744 206336 at CXCL6

1280 213831_at HLA-DQA1 /// 634 205064 at SPRR1 B 554 204455_at DST /

LOC100507718 /// 1602 222890 at CCDC1 13 LOC100652766 LOC100509457 589 204719 at ABCA8 2024 230147 at F2RL2

988 210065 s at UPK1 B 1603 222891 s at BCL1 1 A 1927 228038 at SOX2

559 204475 at MMP1 1513 220030 at STYK1 2133 235737 at TSLP

779 206884 s at SCEL 2007 229542 at C20orf85 703 205767 at EREG

2020 230040 at ADAMTS18 1274 213796 at SPRR1 A 734 206165 s at CLCA2

681 205513 at TCN1 2160 237625 s at 21 1 1 235075 at DSG3

1507 219936 s at GPR87 1509 219962 at ACE2 1 109 21 1906 s at SERPINB4

569 204597 x at STC1 2206 242268 at CELF2 998 210163 at CXCL1 1

1792 226281 at DNER 1373 217109 at MUC4 2144 236203_at HLA-DQA1 /

2054 231202 at ALDH1 L2 45 1556037 s at HHI P LOC100507718 /

781 206924 at IL1 1 632 205044 at GABRP LOC100509457

1904 227702 at CYP4X1 1568 222071 s at SLC04C1 2090 232629 at PROK2

979 209960 at HGF 2222 243610 at C9orf135 50 1557636 a at C7orf57

1965 228592 at MS4A1 797 207430 s at MSMB 6 1552487 a at BNC1

912 209351 at KRT14 538 204304 s at PROM1 151 1 219995 s at ZNF750

393 203184 at FBN2 1641 223836 at FGFBP2 2183 239150 at SNTN

991 210096 at CYP4B1 572 204614 at SERPINB2 46 1556185 a at STEAP4

1376 217272 s at SERPINB13 42 1555854_at AKR1 C1 /// AKR1 C2 952 209720 s at SERPINB3

1629 223475 at CRISPLD1 /// LOC 100653286 ^* : probe number in the microarra

1922 227952 at 1324 214651_s_at HOXA10-HOXA9 ///

735 206166 s at CLCA2 HOXA9 /// MI R196B Affymetrix U133 Plus 2.0

2060 231644 at 733 206157 at PTX3

697 205680 at MMP10 1297 214146 s at PPBP ^** : Set.lD in the microarray Affymetri

28 1554997 a at PTGS2 2152 236489 at GPR1 10 U133 Plus 2.0

767 206638 at HTR2B 1981 228854 at

749 206382 s at BDNF 2193 240259_at FLRT2 ///

1861 227198 at AFF3 LOC100506718

1339 215101 s at CXCL5 924 209480 at HLA-DQB1

2004 229461 x at NEGRI 2061 231647 s at FCRL5

980 209990 s at GABBR2 1382 217528 at CLCA2

2121 235385 at MARCH1 1640 223775 at HHI P

2085 232489 at TRMT13 818 207935 s at KRT13

Table 3 : Alternative list of analyzed genes Probe* Set.lD** Gene. Symbol Probe* Set.lD** Gene.Symbol

2371 1555497 a at CYP4B1 8966 1568964 x at SPN

Probe* Set.lD** Gene. Symbol 2450 1555613 a at ZAP70 9163 1569344 a at

3 1 17 at HSPA6 2467 1555638 a at SAMSN1 9349 1569652 at MLLT3

9 1405 i at CCL5 2501 1555691_a_at KLRC4-KLRK1 /// 10400 200951 s at CCND2

62 1552326 a at CCDC1 1 KLRK1 10402 200953 s at CCND2

83 1552365 at SCIN 2529 1555731 a at AP1 S3 10491 201042 at TGM2

84 1552367 a at SCIN 2549 1555756 a at CLEC7A 10507 201058 s at MYL9

91 1552378 s at RDH10 2552 1555759 a at CCL5 10567 201 1 18 at PGD

155 1552477 a at I RF6 2565 1555778 a at POSTN 10580 201 131 s at CDH1

174 1552502 s at RHBDL2 2566 1555779 a at CD79A 10596 201 147 s at TIMP3

209 1552553 a at NLRC4 2723 1555997 s at IGFBP5 10598 201 149 s at TIMP3

231 1552584 at IL12RB1 2727 1556003 a at LOC100506777 10599 201 150 s at TIMP3

238 1552594 at TMEM190 2746 1556037 s at HHI P 10691 201242 s at ATP1 B1

270 1552634 a at ZNF101 2840 1556185 a at STEAP4 10735 201286 at SDC1

364 1552767 a at HS6ST2 2857 1556209 at CLEC2B 10736 201287 s at SDC1

387 1552797 s at PROM2 2916 1556300 s at SIM1 10836 201387 s at UCHL1

394 1552806 a at SIGLEC10 3053 1556499 s at COL1 A1 10887 201438 at COL6A3

395 1552807 a at SIGLEC10 3109 1556601 a at SPATA13 10959 201510 at ELF3

606 1553105 s at DSG2 3145 1556657 at 1 1027 201578 at PODXL

616 15531 18 at THEM4 3427 1557080 s at ITGBL1 1 1099 201650 at KRT19

660 1553177 at SH2D1 B 3779 1557636 a at C7orf57 1 1 104 201655 s at HSPG2

748 1553297 a at CSF3R 4054 15581 1 1 at MBNL1 1 1 193 201744 s at LUM

841 1553423 a at SLFN13 4108 1558217 at SLFN13 1 1234 201785 at RNASE1

977 1553589 a at PDZK1 I P1 4334 1558662 s at BANK1 1 1269 201820 at KRT5

989 1553605 a at ABCA13 4522 1558971 at THEMIS 1 1288 201839 s at EPCAM

994 1553613 s at FOXC1 4523 1558972 s at THEMIS 1 1292 201843 s at EFEMP1

1039 1553681 a at PRF1 4587 1559078 at 1 1302 201853 s at CDC25B

1081 1553734 at AK7 4728 1559333 at SRGAP3-AS2 1 1333 201884 at CEACAM5

1249 1553986 at RASEF 4758 1559391 s at 1 1342 201893 x at DCN

1353 1554140 at WDR78 4778 1559425 at 1 1412 201963 at ACSL1

1425 1554240 a at ITGAL 4876 1559584 a at C16orf54 1 1454 202005 at ST14

1432 1554250 s at TRIM73 5325 1560396 at KLHL6 1 1467 202018 s at LTF

1502 1554343 a at STAP1 5326 1560397 s at KLHL6 1 1532 202083 s at SEC14L1

1546 1554406 a at CLEC7A 6651 1562529 s at 1 1561 2021 12 at VWF

1681 1554588 a at TTC30B 7017 1563075 s at 1 1655 202206 at ARL4C

1745 1554676 at SRGN 7029 1563088 a at LOC284837 1 1656 202207 at ARL4C

1794 1554741_s_at FGF7 /// KGFLP1 7316 1563674 at FCRL2 1 1657 202208 s at ARL4C

/// KGFLP2 8086 1565913 at 1 1690 202241 at TRIB1

21 13 1555167 s at NAMPT 8251 1566342 at 1 1759 202310 s at COL1 A1

2150 1555214 a at CLEC7A 8716 1567913 at 1 1760 20231 1 s at COL1 A1

2263 1555355 a at ETS1

1 1790 202341 s at TRIM2 12673 203224 at RFK 13622 204174 at ALOX5AP

1 1791 202342 s at TRIM2 12704 203256 at CDH3 13640 204192 at CD37

1 1806 202357 s at CFB 12738 203290 at HLA-DQA1 13645 204197 s at RUNX3

1 1837 202388 at RGS2 12835 203387 s at TBC1 D4 13646 204198 s at RUNX3

1 1840 202391 at BASP1 12845 203397 s at GALNT3 13716 204268 at S100A2

1 1852 202403 s at COL1 A2 12855 203407 at PPL 13752 204304 s at PROM1

1 1853 202404 s at COL1 A2 12861 203413_at LOC100653018 /// 13827 204379 s at FGFR3

1 1903 202454 s at ERBB3 LOC 100653255 /// 13837 204389 at MAOA

1 1938 202489 s at FXYD3 NELL2 13841 204393 s at ACPP

1 1946 202497 x at SLC2A3 12872 203424 s at IGFBP5 13903 204455_at DST /

1 1947 202498 s at SLC2A3 12901 203453 at SCNN1 A LOC100652766

1 1948 202499 s at SLC2A3 12933 203485 at RTN1 13914 204466 s at SNCA

1 1953 202504 at TRIM29 12957 203509 at SORL1 13916 204468 s at TI E1

1 1973 202524 s at SPOCK2 13009 203561 at FCGR2A 13917 204469 at PTPRZ1

1 1974 202525 at PRSS8 13022 203574 at NFIL3 13920 204472 at GEM

12074 202625 at LYN 13039 203591 s at CSF3R 14000 204552 at INPP4A

12075 202626 s at LYN 13093 203645 s at CD163 14029 204581 at CD22

12190 202741 at PRKACB 13154 203706 s at FZD7 14036 204588 s at SLC7A7

12191 202742 s at PRKACB 13174 203726 s at LAM A3 14043 204595 s at STC1

12197 202748 at GBP2 13195 203747 at AQP3 14044 204596 s at STC1

12239 202790 at CLDN7 13205 203757 s at CEACAM6 14045 204597 x at STC1

12275 202826 at SPINT1 13213 203765 at GCA 14101 204653 at TFAP2A

12280 202831 at GPX2 13272 203824 at TSPAN8 14103 204655 at CCL5

12339 202890 at MAP7 13276 203828 s at IL32 141 15 204667 at FOXA1

12360 202910 s at CD97 13337 203889 at SCG5 14125 204677 at CDH5

12397 202947 s at GYPC 13340 203892 at WFDC2 14127 204679 at KCNK1

12421 202971 s at DYRK2 13358 203910 at ARHGAP29 14129 204681 s at RAPGEF5

12438 202988 s at RGS1 13365 203917 at CXADR 14131 204683 at ICAM2

12440 202990 at PYGL 13369 203921 at CHST2 14179 204731 at TGFBR3

12471 203021 at SLPI 13382 203934 at KDR 14182 204734 at KRT15

12495 203045 at NINJ1 13384 203936 s at MMP9 14198 204750 s at DSC2

12524 203074_at ANXA8 /// 13401 203953 s at CLDN3 14225 204777 s at MAL

ANXA8L1 /// 13410 203962 s at NEBL 14241 204793 at GPRASP1 ANXA8L2 13454 204006_s_at FCGR3A /// 14242 204794 at DUSP2

12533 203083 at THBS2 FCGR3B 14250 204802 at RRAD

12572 203123 s at SLC1 1 A2 13455 204007 at FCGR3B 14251 204803 s at RRAD

12575 203126 at IMPA2 13520 204072 s at FRY 14259 20481 1 s at CACNA2D2

12580 203131 at PDGFRA 13564 2041 16 at IL2RG 14269 204821 at BTN3A3

12589 203140 at BCL6 13608 204160 s at ENPP4 14294 204846 at CP

12629 203180 at ALDH1 A3 13609 204161 s at ENPP4 14303 204855 at SERPINB5

Probe* Set.lD** Gene. Symbol Probe* Set.lD** Gene. Symbol Probe* Set.lD** Gene.Symbol

14338 204890 s at LCK 14976 205528 s at RUNX1 T1 15506 206059 at ZNF91

14380 204932 at TNFRSF1 1 B 14980 205532 s at CDH6 15546 206099 at PRKCH

14381 204933 s at TNFRSF1 1 B 14992 205544 s at CR2 15558 2061 1 1 at RNASE2

14397 204949 at ICAM3 14995 205547 s at TAGLN 15565 2061 18 at STAT4

14409 204961 _s_at NCF1 /// NCF1 B /// 15016 205568 at AQP9 15567 206120 at CD33

NCF1 C 15038 205590 at RASGRP1 15597 206150 at CD27

14462 205014 at FGFBP1 15043 205595 at DSG3 15604 206157 at PTX3

14489 205041 s at ORM1 /// ORM2 15045 205597 at SLC44A4 1561 1 206164 at CLCA2

14492 205044 at GABRP 15060 205612 at MMRN1 15612 206165 s at CLCA2

14497 205049 s at CD79A 15071 205623 at ALDH3A1 15613 206166 s at CLCA2

14512 205064 at SPRR1 B 151 19 205671 s at HLA-DOB 15618 206171 at ADORA3

14516 205068 s at ARHGAP26 15129 205681 at BCL2A1 15619 206172 at IL13RA2

14567 2051 19 s at FPR1 15157 205709 s at CDS1 15644 206197 at NME5

14595 205147 x at NCF4 15173 205725 at SCGB1 A1 15653 206206 at CD180

14605 205157 s at JUP /// KRT17 15206 205758 at CD8A 15654 206207 at CLC

14607 205159 at CSF2RB 15213 205765 at CYP3A5 15669 206222 at TNFRSF10C

14619 205171 at PTPN4 15216 205768 s at SLC27A2 15691 206244 at CR1

14622 205174 s at QPCT 15217 205769 at SLC27A2 15723 206276 at LY6D

14628 205180 s at ADAM8 15228 205780 at BIK 15771 206324 s at DAPK2

14633 205185 at SPINK5 15238 205790 at SKAP1 15778 206331 at CALCRL

14634 205186 at DNALI 1 15246 205798 at IL7R 15810 206363 at MAF

14638 205190 at PLS1 15269 205821_at KLRC4-KLRK1 /// 15813 206366 x at XCL1

14661 205213 at ACAP1 KLRK1 15824 206377 at FOXF2

14662 205214 at STK17B 15276 205828 at MMP3 15845 206398 s at CD19

14668 205220 at HCAR3 15279 205831 at CD2 15847 206400_at LGALS7 /

14715 205267 at POU2AF1 15294 205846 at PTPRB LGALS7B

14739 205291 at IL2RB 15331 205883 at ZBTB16 1591 1 206464 at BMX

14745 205297 s at CD79B 15336 205888 s at JAKMIP2 15925 206478 at KIAA0125

14767 205319 at PSCA 15338 205890 s at GABBR1 /// UBD 15928 206481 s at LDB2

14776 205328 at CLDN10 15346 205898 at CX3CR1 15962 206515 at CYP4F3

14851 205403 at IL1 R2 15347 205899 at CCNA1 15969 206522 at MGAM

14870 205422 s at ITGBL1 15349 205901 at PNOC 15992 206545 at CD28

14882 205434 s at AAK1 15364 205916 at S100A7 16008 206561 s at AKR1 B10

14904 205456 at CD3E 15370 205922 at VNN2 16031 206584 at LY96

14918 205470 s at KLK1 1 15372 205924 at RAB3B 16042 206595 at CST6

14924 205476 at CCL20 15427 205979 at SCGB2A1 16078 206631 at PTGER2

14936 205488 at GZMA 15438 205990 s at WNT5A 16084 206637 at P2RY14

14943 205495 s at GNLY 15476 206028 s at MERTK 16090 206643 at HAL

14949 205501 at PDE10A 15480 206032 at DSC3 161 13 206666 at GZMK

14961 205513 at TCN1 15481 206033 s at DSC3 16123 206676 at CEACAM8

16130 206683 at ZNF165 17869 208450 at LGALS2 19129 209720 s at SERPINB3

16154 206707 x at FAM65B 17907 208488 s at CR1 19200 209791 at PADI2

16208 206761 at CD96 17958 208539 x at SPRR2B 19201 209792 s at KLK10

16232 206785 s at KLRC1 /// KLRC2 18026 208607_s_at SAA1 /// SAA2 /// 19220 209813 x at TARP

16251 206804 at CD3G SAA2-SAA4 19222 209815 at PTCH1

16331 206884 s at SCEL 18195 208779 x at DDR1 /// MI R4640 19248 209841 s at LRRN3

16361 206914 at CRTAM 18431 209016 s at KRT7 19270 209863 s at TP63

16371 206924 at IL1 1 18485 209070 s at RGS5 19271 209864 at FRAT2

16425 206978 at CCR2 18486 209071 s at RGS5 19278 209871 s at APBA2

16430 206983 at CCR6 18502 209087 x at MCAM 19288 209881 s at LAT

16455 207008 at CXCR2 18529 2091 14 at TSPAN1 19301 209894 at LEPR

16465 207018 s at RAB27B 18535 209120 at NR2F2 19312 209905_at HOXA10-HOXA9

16519 207072 at IL18RAP 18536 209121 x at NR2F2 /// HOXA9

16523 207076 s at ASS1 18540 209125 at KRT6A 19332 209925 at OCLN

16541 207094 at CXCR1 18541 209126 x at KRT6B 19337 209930 s at NFE2

16558 2071 1 1 at EMR1 18553 209138 x at IGLC1 19353 209946 at VEGFC

16616 207169 x at DDR1 /// MI R4640 18574 209159 s at NDRG4 19356 209949 at NCF2

16624 207178 s at FRK 18588 209173 at AGR2 19362 209955 s at FAP

16721 207275 s at ACSL1 18594 209179 s at MBOAT7 19400 209993 at ABCB1

16737 207291 at PRRG4 18599 209184 s at I RS2 19402 209995 s at TCL1 A

16758 207313_x_at KI R3DL1 /// 18600 209185 s at I RS2 19432 210026 s at CARD10

KI R3DL2 /// 18615 209200 at MEF2C 19437 210031 at CD247 LOC727787 18626 20921 1 at KLF5 19444 210038 at PRKCQ

16773 207328 at ALOX15 18627 209212 s at KLF5 19445 210039 s at PRKCQ

16795 207351 s at SH2D2A 18704 209289 at NFIB 19470 210064 s at UPK1 B

16873 207430 s at MSMB 18705 209290 s at NFIB 19471 210065 s at UPK1 B

16912 207469 s at PI R 18749 209335 at DCN 19501 210096 at CYP4B1

16952 207509 s at LAI R2 18765 209351 at KRT14 19510 210105 s at FYN

17052 207610 s at EMR2 18782 209368 at EPHX2 19522 2101 17 at SPAG1

17093 207651 at GPR171 18788 209374 s at IGHM 19524 2101 19 at KCNJ15

17097 207655 s at BLNK 18809 209395 at CHI3L1 19545 210140 at CST7

171 19 207677 s at NCF4 18810 209396 s at CHI3L1 19569 210164 at GZMB

17165 207723 s at KLRC3 18820 209406 at BAG2 19581 210176 at TLR1

17237 207795 s at KLRD1 18943 209529 at PPAP2C 19589 210184 at ITGAX

17244 207802 at CRISP3 18953 209539 at ARHGEF6 19624 210222 s at RTN1

17259 207819 s at ABCB4 18993 209582 s at CD200 19645 210244 at CAMP

17287 207847 s at MUC1 19080 209670 at TRAC 19698 210297 s at MSMB

17372 207935 s at KRT13 19081 209671 x at TRAC 19721 210321 at GZMH

1741 1 207979 s at CD8B 19095 209686 at S100B 19747 210347 s at BCL1 1 A

17693 208268 at ADAM28 19128 209719 x at SERPINB3 19755 210356 x at MS4A1

19796 210397 at DEFB1 20962 21 1637_x_at IGH@ /// IGHA1 /// 22333 213029 at NFIB

19812 210413_x_at SERPINB3 /// IGHA2 /// IGHD /// 22398 213094 at GPR126

SERPINB4 IGHG1 /// IGHG3 22413 213109 at TNIK

19821 210422 x at SLC1 1 A1 /// IGHG4 /// IGHM 22475 213172 at TTC9

19825 210426 x at RORA /// IGHV3-23 /// 22543 213240 s at KRT4

19847 210448 s at P2RX5 IGHV4-31 22544 213241 at PLXNC1

19876 210479 s at RORA 20969 21 1644 x at IGK@ /// IGKC 22582 213280 at RAP1 GAP2

19881 210484_s_at LOC254896 /// 20970 21 1645 x at 22587 213285 at TMEM30B

TNFRSF10C 20982 21 1657 at CEACAM6 22640 213338 at TMEM158

19897 210505 at ADH7 21007 21 1685 s at NCALD 22694 213392 at IQCK

19992 210606 x at KLRD1 21009 21 1687 x at KI R3DL1 22720 213418 at HSPA6

20098 210715 s at SPINT2 21055 21 1734 s at FCER1 A 22727 213425 at WNT5A

20131 210749 x at DDR1 /// MI R4640 21 123 21 1806 s at KCNJ15 22777 213475 s at ITGAL

20136 210754 s at LYN 21 130 21 1813 x at DCN 22836 213534 s at PASK

20154 210772 at FPR2 21205 21 1896 s at DCN 22843 213541 s at ERG

20155 210773 s at FPR2 2121 1 21 1902 x at YME1 L1 22912 21361 1 at AQP5

20208 210827 s at ELF3 21215 21 1906 s at SERPINB4 22921 213620 s at ICAM2

20228 210847 x at TNFRSF25 21231 21 1922 s at CAT 22975 213674 x at IGHD

20270 210895 s at CD86 21267 21 1959 at IGFBP5 22980 213679 at TTC30A

20340 210972_x_at TRAC /// TRAJ17 21377 212070 at GPR56 22981 213680 at KRT6B

/// TRAV20 21543 212236 x at JUP /// KRT17 22994 213693 s at MUC1

20360 210992 x at FCGR2C 21546 212239 at PIK3R1 23038 213737 x at GOLGA8IP

20373 21 1005 at LAT 21547 212240 s at PIK3R1 23097 213796 at SPRR1 A

20508 21 1 144 x at TARP /// TRGC2 21556 212249 at PIK3R1 231 18 213817 at IRAK3

20526 21 1 163 s at TNFRSF10C 21617 21231 1 at SEL1 L3 23131 213830 at YME1 L1

20554 21 1 192 s at CD84 21638 212332 at RBL2 23150 213849 s at PPP2R2B

20625 21 1272 s at DGKA 21660 212354 at SULF1 23206 213906 at MYBL1

20646 21 1302 s at PDE4B 21666 212360 at AMPD2 23208 213908_at WHAMMP2 /

20678 21 1339 s at ITK 21792 212486 s at FYN WHAMMP3

20679 21 1340 s at MCAM 21807 212501 at CEBPB 23215 213915 at NKG7

20698 21 1361 s at SERPINB13 21837 212531 at LCN2 23229 213929 at EXPH5

20709 21 1372 s at IL1 R2 21905 212599 at AUTS2 23254 213954 at FAM169A

20731 21 1395 x at FCGR2C 21944 212638 s at WWP1 23332 214032 at ZAP70

20845 21 1518 s at BMP4 22126 212820 at DMXL2 23349 214049 x at CD7

20859 21 1532_x_at KI R2DS1 /// 22133 212827 at IGHM 23361 214061 at WDR67

KI R2DS2 /// 22135 212829 at PI P4K2A 23370 214070 s at ATP10B KI R2DS3 /// 22149 212843 at NCAM1 23371 214071 at GNAL

KI R2DS4 /// 22214 212909 at LYPD1 23483 214183 s at TKTL1

KI R2DS5 /// 22246 212942 s at KIAA1 199 23540 214240 at GAL

KI R3DL3 22279 212975 at DENND3 23738 214438 at HLX

20923 21 1597 s at HOPX

23750 214450 at CTSW 25100 215806 x at TARP /// TRGC2 27558 218272 at TTC38

23756 214456 x at SAA1 /// SAA2 25219 215925 s at CD72 27605 218319 at PELI1

23770 214470 at KLRB1 25239 215945 s at TRIM2 27639 218353 at RGS5

23849 214549 x at SPRR1 A 25283 215990 s at BCL6 27754 218468 s at GREM1

23867 214567 s at XCL1 /// XCL2 25326 216033 s at FYN 27755 218469 at GREM1

23879 214580_x_at KRT6A /// KRT6B 25484 216191 s at TRDV3 27787 218501 at ARHGEF3

/// KRT6C 25500 216207_x_at IGKC /// 27796 218510 x at FAM134B

23881 214582 at PDE3B LOC642838 27818 218532 s at FAM134B

23916 214617 at PRF1 25545 216252 x at FAS 27900 218614 at C12orf35

23950 214651_s_at HOXA10-HOXA9 25693 216401 x at 27962 218677 at S100A14

/// HOXA9 /// 25783 216491 x at IGHM 27972 218687 s at MUC13 MIR196B 25867 216576 x at IGK@ /// IGKC 27977 218692 at SYBU

23966 214669 x at IGKC 25914 216623 x at TOX3 27985 218700 s at RAB7L1

24020 214723 x at ANKRD36 26125 216834 at RGS1 27996 21871 1 s at SDPR

24065 214768 x at IGKC 26132 216841_s_at LOC100129518 /// 28024 218739 at ABHD5

24071 214774 x at TOX3 SOD2 28085 218800 at SRD5A3

24074 214777 at 26196 216905 s at ST14 28090 218805_at GIMAP1 -GIMAP5

24100 214803 at CDH6 2621 1 216920 s at TARP /// TRGC2 /// GIMAP5

24132 214836_x_at IGK@ /// IGKC /// 26236 216945 x at PASK 28161 218876 at TPPP3

LOC100294406 26275 216984_x_at CKAP2 /// IGLC1 28170 218885 s at GALNT12

24212 214916_x_at IGHA1 /// IGHA2 /// /// IGLV1 -44 28186 218901 at PLSCR4

IGHG1 /// IGHG3 26398 217109 at MUC4 28234 218949 s at QRSL1 /// IGHM /// IGHV3- 26399 2171 10 s at MUC4 28245 218960 at TMPRSS4 23 /// IGHV4-31 26431 217143 s at YME1 L1 28251 218966 at MY05C

24241 214945_at FAM153A /// 26436 217148 x at CKAP2 /// IGLC1 28275 218990 s at SPRR3

FAM153B /// 26558 217272 s at SERPINB13 28280 218995 s at EDN1

FAM153C /// 26704 217418 x at MS4A1 28295 219010 at C1 orf106 LOC 100507387 /// 26807 217521 at HAL 28376 219091 s at MMRN2 LOC100507427 26814 217528 at CLCA2 28400 2191 15 s at IL20RA

24291 214995_s_at APOBEC3F /// 26838 217552 x at CR1 28406 219121 s at ESRP1

APOBEC3G

27024 217738 at NAMPT 28444 219159 s at SLAMF7

24344 215049 x at CD163

27025 217739 s at NAMPT 28446 219161_s_at CKLF /// CKL

24368 215073 s at NR2F2

27053 217767 at C3 CMTM1

24403 215108 x at TOX3

27187 217901 at DSG2 28464 219179 at DACT1

24470 215175 at PCNX

27252 217966 s at FAM129A 28467 219182 at TMEM231

24471 215176 x at LOC642838

27253 217967 s at FAM129A 28468 219183 s at CYTH4

24518 215223_s_at LOC100129518 ///

27263 217977 at MSRB1 28589 219304 s at PDGFD SOD2

27269 217983 s at RNASET2 28598 219313 at GRAMD1 C

24627 215332 s at CD8B

27422 218136 s at SLC25A37 28653 219368 at NAP1 L2

24915 215621 s at IGHD

27472 218186 at RAB25 28668 219383 at PRR5L

25023 215729 s at VGLL1

28708 219423 x at TNFRSF25 29458 220173 at C14orf45 31762 222482 at SSBP3

28714 219429 at FA2H 29462 220177 s at TMPRSS3 31808 222528 s at SLC25A37

28719 219434 at TREM1 29615 220330 s at SAMSN1 31809 222529 at SLC25A37

28721 219436 s at EMCN 29689 220404 at GPR97 31829 222549 at CLDN1

28735 219450 at C4orf19 29753 220468 at ARL14 31966 222686 s at CPPED1

28737 219452 at DPEP2 29770 220485 s at SI RPG 31992 222712 s at MUC13

28761 219476 at C1 orf1 16 29827 220542 s at BPI FA1 31997 222717 at SDPR

28783 219498 s at BCL1 1 A 29931 220646 s at KLRF1 32030 222750 s at SRD5A3

28793 219508 at GCNT3 30225 220940 at ANKRD36B 32053 222773 s at GALNT12

28813 219528 s at BCL1 1 B 30275 220990 s at MIR21 /// VMP1 32083 222803 at PRTFDC1

28814 219529 at CLIC3 30314 221029 s at WNT5B 321 10 222830 at GRHL1

28865 219580 s at TMC5 30365 221081 s at DENND2D 321 13 222833 at LPCAT2

28879 219594 at NINJ2 30406 221 122 at HRASLS2 321 18 222838 at SLAMF7

28915 219630 at PDZK1 I P1 30469 221 185 s at IQCG 32165 222885 at EMCN

28951 219666 at MS4A6A 30494 221210 s at NPL 32170 222890 at CCDC1 13

28952 219667 s at BANK1 30523 221239 s at FCRL2 32171 222891 s at BCL1 1 A

28967 219682 s at TBX3 30537 221253_s_at MUTED-TXNDC5 32175 222895 s at BCL1 1 B

28985 219700 at PLXDC1 /// TXN DC5 32184 222904 s at TMC5

29012 219727 at DUOX2 30629 221345 at FFAR2 32195 222915 s at BANK1

29053 219768 at VTCN1 30930 221648 s at AG MAT 32214 222934 s at CLEC4E

29062 219777 at GIMAP6 30933 221651_x_at IGK@ /// IGKC /// 32556 223278 at GJB2

29080 219795 at SLC6A14 LOC100294406 32560 223282 at TSHZ1

29084 219799 s at DHRS9 30953 221671_x_at IGK@ /// IGKC /// 32561 223283 s at TSHZ1

29091 219806 s at C1 1 orf75 LOC100294406 32593 223315 at NTN4

29097 219812 at PVRIG 30967 221685 s at CCDC99 32683 223405 at NPL

29135 219850 s at EHF 31037 221756 at PIK3IP1 32762 223484 at C15orf48

29177 219892 at TM6SF1 31071 221790 s at LDLRAP1 32828 223551 at PKIB

2921 1 219926 at POPDC3 31200 221919 at HNRNPA1 32846 223569 at PPAPDC1 B

29221 219936 s at GPR87 31201 221920 s at SLC25A37 32897 223620 at GPR34

29223 219938 s at PSTPIP2 31227 221946 at C9orf1 16 32908 223631 s at C19orf33

29244 219959 at MOCOS 31250 221969 at PAX5 32913 223636 at ZMYN D12

29247 219962 at ACE2 31254 221973_at LOC 100506076 /// 3301 1 223734 at MGARP

29270 219985 at HS3ST3A1 LOC100506123 33014 223737 x at CHST9

29280 219995 s at ZNF750 31352 222071 s at SLC04C1 33025 223748 at SLC4A1 1

29299 220014 at PRR16 31354 222073 at COL4A3 33052 223775 at HHIP

2931 1 220026 at CLCA4 31369 222088_s_at SLC2A14 /// 33061 223784 at TMEM27

29344 220059 at STAP1 SLC2A3 33086 223809 at RGS18

29353 220068 at VPREB3 31551 222271 at 331 13 223836 at FGFBP2

29373 220088 at C5AR1 31565 222285 at IGHD 33198 223922 x at MS4A6A

29446 220161 s at EPB41 L4B 31597 222317 at PDE3B 33228 223952 x at DHRS9

33284 224009 x at DHRS9 LOC100653241 /// 36100 226844 at MOB3B

33462 224189_x_at EHF LOC 100653346 /// 361 19 226863 at FAM1 10C

33481 224209 s at GDA LOC729737 36132 226876 at FAM101 B

33589 224321 at TMEFF2 35232 225975 at PCDH18 36134 226878 at HLA-DOA

33595 224327 s at DGAT2 35278 226021 at RDH10 36161 226905 at FAM101 B

33623 224356 x at MS4A6A 35285 226028 at ROB04 36206 226950 at ACVRL1

33625 224358 s at MS4A7 35296 226039 at MGAT4A 36216 226960 at CXCL17

33641 224374 s at EMILIN2 35321 226064 s at DGAT2 36217 226961 at PRR15

33664 224400 s at CHST9 35322 226065 at PRICKLE1 36247 226991 at NFATC2

33670 224406 s at FCRL5 35324 226067 at BPI FB1 36288 227032 at PLXNA2

33676 224412 s at TRPM6 35326 226069 at PRICKLE1 36337 227081 at DNALI1

33698 224435 at FAM213A 35402 226145 s at FRAS1 36343 227087 at INPP4A

33725 224463 s at C1 1 orf70 35404 226147 s at PIGR 36375 2271 19 at CNOT6L

33910 224650 at MAL2 35407 226150 at PPAPDC1 B 36385 227129 x at FLJ45340

34043 224784 at MLLT6 35436 226179 at SLC25A37 36436 227180 at ELOVL7

34054 224795_x_at IGK@ /// IGKC /// 35442 226185 at CDS1 36452 227196 at RHPN2

LOC100294406 35446 226189 at ITGB8 36454 227198 at AFF3

34223 224964 s at GNG2 35470 226213 at ERBB3 36484 227228 s at CCDC88C

34339 225081 s at CDCA7L 35475 226218 at IL7R 36494 227238 at MUC15

34557 225299 at MY05B 35501 226244 at CLEC14A 36497 227241 at MUC15

34559 225301 s at MY05B 35529 226272 at RCAN3 36509 227253 at CP

34822 225564 at SPATA13 35532 226275 at MXD1 36517 227261 at KLF12

34855 225597 at SLC45A4 35604 226347 at FUT1 1 36545 227289 at PCDH17

34856 225598 at SLC45A4 35605 226348 at 36600 227344 at IKZF1

34884 225626 at PAG1 35631 226374 at CXADR 36609 227353 at TMC8

34903 225645 at EHF 35641 226384 at PPAPDC1 B 36610 227354 at PAG1

34925 225667 s at FAM84A 35681 226424 at CAPS 36615 227359 at OSCP1

34939 225681 at CTHRC1 35690 226433 at RNF157 36628 227372 s at BAIAP2L1

34986 225728 at SORBS2 35737 226480 at 36639 227383 at LOC727820

35025 225767 at RN45S 35792 226535 at ITGB6 36640 227384_s_at LOC727820 /

35075 225817 at CGNL1 35805 226548 at SBK1 LOC728855 /

35104 225846 at ESRP1 35817 226560 at LOC728875

35157 225899_x_at FLJ45340 /// 35878 226622 at MUC20 36706 227450 at ERP27

FLJ45445 /// 35881 226625 at TGFBR3 36717 227461 at STON2

LOC100128326 /// 35938 226682 at RORA 36731 227475 at FOXQ1

LOC100132050 /// 35951 226695 at PRRX1 36748 227492_at LOC647859 / LOC 100287894 /// 36033 226777 at ADAM12 OCLN

LOC 100289306 /// 36059 226803 at CHMP4C 36788 227533 at

LOC 100506479 /// 36073 226817 at DSC2 36821 227566_at LOC100653217 / LOC 100508632 /// 36097 226841 at MPEG1 NTM

LOC 100652945 ///

36896 227641 at FBXL16 37804 228549 at 39097 229842 at ELF3

36901 227646 at EBF1 37830 228575 at IL20RB 39165 229910 at SHE

36941 227686 at OXNAD1 37847 228592 at MS4A1 39189 229934 at

36960 227705 at TCEAL7 37854 228599 at MS4A1 39192 229937 x at

36972 227717 at ARHGEF37 37903 228648 at LRG1 39285 230030 at HS6ST2

36980 227725 at ST6GALNAC1 37932 228677 s at RASAL3 39298 230043 at MUC20

37002 227747 at MPZL3 37948 228693 at CCDC50 39306 230051 at C10orf47

37010 227755 at 37962 228707 at CLDN23 39316 230061 at TM4SF18

37024 227769 at GPR27 38013 228758 at BCL6 39348 230093 at RSPH1

37034 227779 at 38017 228762 at LFNG 39390 230135 at HHIP

37035 227780 s at ECSCR 38021 228766 at CD36 39448 230193 at WDR66

37122 227867 at TRABD2A 38029 228774 at CEP78 39462 230207 s at DOCK5

37129 227874 at EMCN 38043 228788 at YPEL1 39500 230245 s at LOC283663

37132 227877 at ANXA2R 38082 228827 at RUNX1 T1 39505 230250 at PTPRB

37144 227889 at LPCAT2 38086 228831 s at GNG7 39518 230263 s at DOCK5

37178 227923 at SHANK3 38109 228854 at 39578 230323 s at TMEM45B

37221 227966_s_at CCDC74A /// 381 18 228863 at PCDH17 39588 230333 at

CCDC74B 38120 228865 at C1 orf1 16 39615 230360 at GLDN

37293 228038 at SOX2 38224 228969 at AGR2 39633 230378 at SCGB3A1

37322 228067 at C2orf55 38267 229012 at C9orf24 39719 230464 at S1 PR5

37349 228094 at AMICA1 38276 229021 at MCTP2 39754 230499 at BIRC3

37355 228100 at C1 orf88 38327 229072 at RAB30 39781 230526 at LOC100131096

37363 228108 at PPM1 L 38402 229147 at RASSF6 39805 230550 at MS4A6A

37398 228143 at CP 38483 229228_at CREB5 /// 39818 230563 at RASGEF1 A

37496 228241 at AGR3 LOC401317 39962 230707 at SORL1

37538 228283 at CMC1 38508 229253 at THEM4 39963 230708 at PRICKLE1

37553 228298 at PCED1 B 38509 229254 at MFSD4 39977 230722 at BNC2

37590 228335 at CLDN1 1 38582 229327 s at 39996 230741 at

37594 228339 at ECSCR 38622 229367 s at GIMAP6 40001 230746 s at

37602 228347 at SIX1 38632 229377 at GRTP1 40018 230763 at SPATA17

37627 228372 at C10orf128 38684 229429_x_at LOC728855 /// 40046 230791 at

37632 228377 at KLHL14 LOC728875 40225 230970 at

37636 228381 _at ATF7IP2 /// 38765 229510 at MS4A14 40332 231077 at C1 orf192

LOC100287628 38768 229513 at STRBP 40353 231098 at

37645 228390 at RAB30 38797 229542 at C20orf85 40379 231 124 x at LY9

37697 228442 at NFATC2 38821 229566 at LOC645638 40400 231 145 at PAX9

37705 228450 at PLEKHA7 38839 229584 at LRRK2 40421 231 166 at GPR155

37744 228489 at TM4SF18 38878 229623 at 40482 231227 at WNT5A

37773 228518 at IGHG1 /// IGHM 38903 229648 at ARHGAP32 40529 231274 s at

37783 228528 at 39042 229787 s at 40538 231283 at MGAT4A

40902 231647 s at FCRL5 44650 235400 at FCRLA 47808 238558 at

40943 231688 at MMP8 44651 235401 s at FCRLA 47834 238584 at IQCA1

40983 231728 at CAPS 44708 235458 at HAVCR2 47869 238619 at

40984 231729 s at CAPS 44726 235476 at TRIM59 47873 238623 at

41026 231771 at GJB6 44739 235489 at RHOJ 47939 238689 at GPR1 10

41031 231776 at EOMES 44817 235567 at RORA 47970 238720 at LOC100506582

41092 231837 at USP28 44833 235583 at ILDR1 48102 238852 at PRRX1

41 196 231941 s at MUC20 44841 235591 at SSTR1 48155 238905 at RHOJ

41282 232027 at SYNE1 44990 235740 at MCTP1 48255 239005 at

4131 1 232056 at SCEL 45001 235751 s at VM01 48400 239150 at SNTN

41337 232082 x at SPRR3 45013 235763 at SLC44A5 48481 239231 at

41406 232151 at MACC1 45048 235798 at TMEM170B 48537 239287 at

41419 232164 s at EPPK1 45169 235919 at CEP78 48542 239292 at

41459 232204 at EBF1 45174 235924 at 48692 239442 at CEP68

41465 232210 at 45238 235988 at GPR1 10 48848 239598 s at LPCAT2

41468 232213 at PELI 1 45335 236085 at CAPSL 48923 239673 at

41489 232234 at SLA2 45476 236226 at BTLA 49058 239808 at

41559 232304 at PELI 1 45512 236262 at MMRN2 49166 239916 at WDR16

41782 232527 at PSMD6-AS2 45545 236295_s_at MIR3929 /// 49315 240065 at FAM81 B

41869 232614 at NLRC3 49320 240070 at TIGIT

41870 232615 at 45629 236379 at 4941 1 240161 s at CDC20B

41884 232629 at PROK2 45671 236421 at ANKRD45 49423 240173 at

41942 232687 at 45689 236439 at 49553 240303 at TMC5

42136 232882 at 45739 236489 at GPR1 10 49554 240304 s at TMC5

42143 232889 at 45789 236539 at PTPN22 49663 240413 at PYHIN1

42752 233500 x at CLEC2D 45906 236656 s at LOC10028891 1 49716 240466 at

42942 233690 at 46032 236782 at SAMD3 49749 240499 at

43557 234306 s at SLAMF7 46157 236907 at 49822 240572 s at LOC374443

43582 234331 s at FAM84A 46716 237466 s at HHI P 50080 240830 at SCARNA17

44014 234764_x_at CKAP2 /// IGLC1 46875 237625 s at 501 1 1 240861 at

/// IGLV1 -44 46987 237737 at LOC100289026 50448 241 198 s at C1 1 orf70

44220 234970 at TC2N 47267 238017 at SDR16C5 50662 241412 at BTC

44246 234996 at CALCRL 47313 238063 at TMEM154 50685 241435 at

44325 235075 at DSG3 47353 238103 at LOC100505989 50931 241681 at

44391 235141 at MARVELD2 47366 2381 16 at DYNLRB2 51053 241803 s at

44394 235144 at RASEF 47371 238121 at GK5 51 135 241885 at

44449 235199 at RNF125 47679 238429 at TMEM71 51713 242463 x at ZNF600

44523 235273 at DYX1 C1 47710 238460 at FAM83A 52059 242809 at IL1 RL1

44528 235278 at MACROD2 47728 238478 at BNC2 52121 242871 at PAQR5

44622 235372 at FCRLA 47774 238524 at 52157 242907 at GBP2

52404 243154 at 3838 1557718 at PPP2R5C 12064 202615 at GNAQ

52448 243198 at TEX9 4170 1558369 at MPHOSPH9 121 12 202663 at WIPF1

52481 243231 at SLC38A1 1 4385 1558747 at SMCHD1 121 14 202665 s at WIPF1

52546 243296 at NAMPT 9325 1569607_s_at ANKRD20A1 /// 12282 202833 s at SERPINA1

52636 243386 at CASZ1 ANKRD20A1 1 P /// 12407 202957 at HCLS1

52663 243413 at TTC30B ANKRD20A2 /// 12516 203066 at CHST15

52694 243444 at SRD5A3 ANKRD20A3 /// 12573 203124 s at SLC1 1 A2

52742 243492 at THEM4 ANKRD20A4 /// 12753 203305 at F13A1

52860 243610 at C9orf135 ANKRD20A5P /// 12834 203386 at TBC1 D4

52979 243729 at ANKRD20A9P /// 12864 203416 at CD53

52995 243745 at LOC644339 12883 203435 s at MME

53030 243780 at 10051 200602 at APP 13098 203650 at PROCR

53259 244008 at PARP8 10055 200606 at DSP 13139 203691 at PI3

53423 244172 at 10097 200648 s at GLUL 13156 203708 at PDE4B

53564 244313 at CR1 10273 200824 at GSTP1 13189 203741 s at ADCY7

53665 244414 at 1031 1 200862 at DHCR24 13327 203879 at PIK3CD

54183 33322 i at SFN 10422 200973 s at TSPAN3 13371 203923 s at CYBB

54184 33323 r at SFN 10477 201028 s at CD99 13409 203961 at NEBL

54267 37145 at GNLY 10668 201219 at CTBP2 13421 203973 s at CEBPD

54309 38241 at BTN3A3 10710 201261 x at BGN 13505 204057 at IRF8

54326 39248 at AQP3 10727 201278 at DAB2 13514 204066 s at AGAP1

54327 39249 at AQP3 10738 201289 at CYR61 13551 204103 at CCL4

54329 39318 at TCL1 A 10750 201301 s at ANXA4 13560 2041 12 s at HNMT

54361 40560 at TBX2 10809 201360 at CST3 13649 204201 s at PTPN13

54514 57082 at LDLRAP1 10816 201367 s at ZFP36L2 13668 204220 at GMFG

54533 59437 at C9orf1 16 10871 201422 at I FI30 13713 204265 s at GPSM3

54557 64064_at GIMAP1 -GIMAP5 1 1012 201563 at SORD 13721 204273 at EDNRB

/// GIMAP5 1 1094 201645 at TNC 13746 204298 s at LOX

54569 64900 at TMEM231 1 1291 201842 s at EFEMP1 13767 204319 s at RGS10

54598 823 at CX3CL1 1 1307 201858 s at SRGN 13776 204328 at TMC6

53 1552315 at GIMAP1 1 1308 201859 at SRGN 13807 204359_at FLRT2 /

55 1552318 at GIMAP1 1 1337 201888 s at IL13RA1 LOC100506718

260 1552623 at HSH2D 1 1388 201939 at PLK2 13894 204446 s at ALOX5

1473 1554306 at ITPKB 1 1448 201999 s at DYNLT1 13912 204464 s at EDNRA

2354 1555471 a at FMN2 1 1607 202158 s at CELF2 13941 204493 at BID

2391 1555526 a at SEPT6 1 1640 202191 s at GAS7 1401 1 204563 at SELL

2522 1555724 s at TAGLN 1 1641 202192 s at GAS7 14068 204620 s at VCAN

2572 1555786 s at LINC00520 1 1914 202465 at PCOLCE 14094 204646 at DPYD

3078 1556543 at 1 1930 202481 at DHRS3 14122 204674 at LRMP

3146 1556658 a at 12030 202581_at HSPA1 A /// 14148 204700 x at DIEXF

HSPA1 B

14161 204713 s at F5 15885 206438 x at TCTN2 19824 210425_x_at GOLGA8A /

14162 204714 s at F5 16065 206618 at IL18R1 GOLGA8B /

14199 204751 x at DSC2 16071 206624 at USP9Y LOC100508892

14228 204780 s at FAS 16212 206765 at KCNJ2 19902 21051 1 s at INHBA

14305 204857 at MAD1 L1 16504 207057 at SLC16A7 20015 210629 x at LST1

14308 204860_s_at LOC 100509323 /// 16603 207156_at HIST1 H2AG /// 20071 210686 x at SLC25A16

NAI P HIST1 H2AH /// 20167 210786 s at FLU

14330 204882 at ARHGAP25 HIST1 H2AI /// 20190 210809 s at POSTN

14339 204891 s at LCK HIST1 H2AK /// 20196 210815 s at CALCRL

14371 204923 at SASH3 HIST1 H2AL /// 20272 210904 s at IL13RA1

14372 204924 at TLR2 HIST1 H2AM 20310 210942 s at ST3GAL6

14407 204959 at MNDA 17085 207643 s at TNFRSF1 A 20404 21 1038 s at CROCCP2

14419 204971 at CSTA 171 16 207674 at FCAR 20450 21 1085 s at STK4

14453 205005 s at NMT2 17219 207777 s at SP140 20465 21 1 100 x at LILRA2

14454 205006 s at NMT2 17297 207857 at LILRA2 20466 21 1 101 x at LILRA2

14481 205033_s_at DEFA1 /// DEFA1 B 17575 208146 s at CPVL 20784 21 1454 x at FKSG49

/// DEFA3 18106 208690 s at PDLIM1 20907 21 1581 x at LST1

14524 205076 s at MTMR1 1 18179 208763 s at TSC22D3 20908 21 1582 x at LST1

14549 205101 at CI ITA 18214 208798 x at GOLGA8A 20938 21 1612 s at IL13RA1

14562 2051 14_s_at CCL3 /// CCL3L1 18274 208858 s at ESYT1 20986 21 1661 x at PTAFR

/// CCL3L3 18365 208949 s at LGALS3 21010 21 1688_x_at KIR3DL1 /

14685 205237 at FCN1 18472 209057 x at CDC5L KIR3DL2 /

14814 205366 s at HOXB6 18498 209083 at COR01 A LOC727787

14854 205406 s at SPA17 18554 209139 s at PRKRA 21046 21 1725 s at BID

14866 205418 at FES 18614 209199 s at MEF2C 21053 21 1732 x at HNMT

14867 205419 at GPR183 18653 209238 at STX3 21063 21 1742 s at EVI2B

14873 205425 at HI P1 18677 209262 s at NR2F6 21069 21 1748 x at PTGDS

15007 205559 s at PCSK5 18707 209292 at I D4 21 1 1 1 21 1794 at FYB

15075 205627 at CDA 18721 209306 s at SWAP70 21228 21 1919 s at CXCR4

15166 205718 at ITGB7 18762 209348 s at MAF 21270 21 1962 s at ZFP36L1

15252 205804 s at TRAF3IP3 18887 209473 at ENTPD1 21281 21 1973 at

15333 205885 s at ITGA4 18968 209555 s at CD36 21497 212190 at SERPINE2

15436 205988 at CD84 19017 209606 at CYTIP 21659 212353 at SULF1

15504 206057 x at SPN 19026 209615 s at PAK1 21688 212382 at TCF4

15507 206060 s at PTPN22 19105 209696 at FBP1 21866 212560 at SORL1

15617 206170 at ADRB2 19340 209933 s at CD300A 21908 212602 at WDFY3

15661 206214 at PLA2G7 19544 210139 s at PMP22 21952 212646 at RFTN1

15724 206277 at P2RY2 19551 210146 x at LILRB2 21978 212672 at ATM

15784 206337 at CCR7 19683 210282 at ZMYM2 21981 212675 s at CEP68

15879 206432 at HAS2 19822 210423_s_at SLC1 1 A1 22077 212771 at FAM171 A1

22220 212915 at PDZRN3 24530 215235 at SPTAN1 28644 219359 at ATHL1

22309 213005 s at KANK1 24564 215269 at TRAPPC10 28697 219412 at RAB38

22336 213032 at NFIB 24638 215343 at CCDC88C 28756 219471 at KIAA0226L

22410 213106 at ATP8A1 24674 215379 x at IGLV1 -44 28781 219496 at SOWAHC

22446 213142 x at PION 24741 215446 s at LOX 28782 219497 s at BCL1 1 A

22496 213193 x at TRBC1 24927 215633 x at LST1 28790 219505 at CECR1

22606 213304 at FAM179B 25013 215719 x at FAS 28916 219631 at LRP12

2261 1 213309 at PLCL2 25207 215913 s at GULP1 29073 219788 at PILRA

22628 213326 at VAMP1 25260 215967 s at LY9 29106 219821 s at GFOD1

22826 213524 s at G0S2 25446 216153 x at RECK 291 18 219833 s at EFHC1

22906 213605 s at 25643 216351_x_at DAZ1 /// DAZ2 /// 29174 219889 at FRAT1

22967 213666 at SEPT6 DAZ3 /// DAZ4 29286 220001 at PADI4

23004 213703 at LINC00342 26198 216907_x_at KI R3DL1 /// 29290 220005 at P2RY13

23034 213733 at MY01 F KI R3DL2 /// 29319 220034 at IRAK3

23166 213865 at DCBLD2 LOC727787 29320 220035 at NUP210

23188 213888 s at TRAF3IP3 26272 216981 x at SPN 29351 220066 at NOD2

23205 213905 x at BGN 26319 217028 at CXCR4 29538 220253 s at LRP12

23247 213947 s at NUP210 26368 217078 s at CD300A 29862 220577 at GVINP1

23384 214084 x at NCF1 C 26435 217147 s at TRAT1 30239 220954 s at PILRB

23431 214131 at TXLNG2P 26759 217473 x at SLC1 1 A1 30272 220987 s at AKIP1 /// NUAK2

23493 214193 s at DI EXF 26913 217627 at ZNF573 30342 221058 s at CKLF

23598 214298 x at SEPT6 27030 217744 s at PERP 30364 221080 s at DENND1 C

23666 214366 s at ALOX5 27124 217838 s at EVL 30491 221207 s at NBEA

23670 214370 at S100A8 27270 217984 at RNASET2 30518 221234 s at BACH2

23739 214439 x at BIN1 27278 217992 s at EFHD2 30533 221249 s at FAM1 17A

23767 214467 at GPR65 27435 218149 s at ZNF395 30864 221581 s at LAT2

23873 214574 x at LST1 27468 218182 s at CLDN1 30867 221584 s at KCNMA1

23880 214581 x at TNFRSF21 27566 218280_x_at HIST2H2AA3 /// 30927 221645 s at ZNF83

23974 214677 x at IGLC1 HIST2H2AA4 30946 221664 s at F1 1 R

24032 214735 at I PCEF1 27608 218322 s at ACSL5 30979 221698 s at CLEC7A

24050 214753 at N4BP2L2 27612 218326 s at LGR4 31259 221978 at HLA-F

24314 215019 x at ZNF528 27690 218404 at SNX10 31431 222150 s at PION

24416 215121_x_at CYAT1 /// IGLC1 /// 27854 218568 at AGK 31499 222218 s at PILRA

IGLV1 -44 28049 218764 at PRKCH 31546 222266 at

24418 215123_at 61 E3.4 /// 28087 218802 at CCDC109B 31609 222329 x at

LOC100132247 /// 28235 218950 at ARAP3 31672 222392 x at PERP

LOC 100652992 /// 28309 219024 at PLEKHA1 31818 222538 s at APPL1 LOC613037 /// 28358 219073 s at OSBPL10 31837 222557 at STMN3 LOC728888 /// 28514 219229 at SLC03A1 31950 222670 s at MAFB

NPI PL3 28564 219279 at DOCK10 32082 222802 at EDN1

24441 215146 s at TTC28

32157 222877 at 34964 225706 at GLCCI 1 37058 227803 at ENPP5

32324 223044 at SLC40A1 34989 225731 at ANKRD50 371 1 1 227856 at C4orf32

32558 223280 x at MS4A6A 35122 225864 at FAM84B 37146 227891 s at TAF15

32621 223343 at MS4A7 35141 225883 at ATG16L2 37155 227900 at CBLB

32622 223344 s at MS4A7 35212 225955 at METRNL 37313 228058 at ZG16B

32753 223475 at CRISPLD1 35279 226022 at SASH1 37326 228071 at GIMAP7

32830 223553 s at DOK3 35283 226026 at DI RC2 37352 228097 at MYLI P

32895 223618 at FMN2 35293 226036 x at CASP2 37360 228105 at

32922 223645 s at TXLNG2P 35639 226382_at CAMK1 D /// 37376 228121 at TGFB2

33258 223983 s at C19orf12 LOC283070 37665 228410 at GAB3

33433 224159 x at TRIM4 35682 226425 at CLI P4 37747 228492 at USP9Y

33553 224284 x at FKSG49 35693 226436 at RASSF4 37767 228512 at PTCD3

33634 224367 at BEX2 35731 226474 at NLRC5 37840 228585 at ENTPD1

33713 224451 x at ARHGAP9 35782 226525 at STK17B 37868 228613 at RAB1 1 FIP3

33958 224698 at ESYT2 36027 226771 at ATP8B2 37895 228640 at PCDH7

33979 224719 s at C12orf57 36045 226789 at EMB 37963 228708 at RAB27B

34058 224799 at NDFI P2 36046 226790 at MORN2 38031 228776 at GJC1

34072 224813 at WASL 36074 226818 at MPEG1 38101 228846 at MXD1

34092 224833 at ETS1 36090 226834 at 38124 228869 at SNX20

34121 224862 at GNAQ 36135 226879 at HVCN1 38134 228879 at SNORD104

34168 224909 s at PREX1 36162 226906 s at ARHGAP9 38174 228919 at

34184 224925 at PREX1 36408 227152 at C12orf35 38219 228964 at PRDM1

34304 225046 at LOC389831 36430 227174 at WDR72 38325 229070 at ADTRP

34314 225056 at SI PA1 L2 36433 227177 at COR02A 38346 229091 s at CCNJ

34385 225127 at TMEM181 36438 227182 at SUSD3 38347 229092 at NR2F2

34395 225137 at NFATC3 36440 227184 at PTAFR 38396 229141 at SFT2D3 /// WDR3

34482 225224 at C20orf1 12 36444 227188 at FAM176C 38527 229272 at FNBP4

34520 225262 at FOSL2 36488 227232 at EVL 38586 229331 at SPATA18

34540 225282 at SMAP2 36635 227379 at MBOAT1 38759 229504 at

34566 225308 s at TANC1 36666 227410 at FAM43A 38778 229523 at

34579 225321 s at PILRB 36723 227467 at RDH10 38801 229546_at FAM84A /

34626 225368 at HI PK2 36862 227607 at STAMBPL1 LOC653602

34645 225387 at TSPAN5 36873 227618 at 38852 229597 s at WDFY4

34665 225407 at MBP 36900 227645 at PIK3R5 38978 229723 at TAGAP

34754 225496 s at SYTL2 36926 227671 at XIST 39086 229831 at CNTN3

34780 225522 at AAK1 36932 227677 at JAK3 39255 230000 at RNF213

34887 225629 s at ZBTB4 36995 227740 at UHMK1 39331 230076 at PITPNM3

34931 225673 at MYADM 37017 227762 at 39434 230179 at LOC285812

34946 225688 s at PHLDB2 37051 227796 at ZFP62 39507 230252 at LPAR5

34959 225701 at AKNA 37053 227798 at SMAD1 39519 230264 s at AP1 S2

39525 230270 at PRPF38B 45774 236524 at 53928 244677 at

39547 230292 at 45804 236554 x at TMC8 54234 35974 at LRMP

39627 230372 at HAS2 4581 1 236561 at TGFBR1 54306 38149 at ARHGAP25

39646 230391 at CD84 46259 237009 at 5431 1 38290 at RGS14

39749 230494 at SLC20A1 47003 237753 at IL21 R 54332 39549 at NPAS2

39924 230669 at RASA2 47591 238341 at 54380 41469 at PI3

40091 230836 at ST8SIA4 47730 238480 at TTC39C 54408 44790 s at KIAA0226L

40121 230866 at CYSLTR1 47763 238513 at PRRG4 54559 64408 s at CALML4

40140 230885 at SPG7 47799 238549 at CBFA2T2 54588 74694 s at RABEP2

40180 230925 at APBB1 I P 47831 238581 at GBP5 54 1552316 a at GIMAP1

40457 231202 at ALDH1 L2 47899 238649 at PITPNC1 170 1552497 a at SLAMF6

41002 231747 at CYSLTR1 47901 238651 at 258 1552621_at POLR2J2 /

41 103 231848 x at ZNF207 48096 238846 at TNFRSF1 1 A POLR2J3 /

4121 1 231956 at RNF213 48130 238880 at GTF3A UPK3BL

41279 232024 at GIMAP2 48385 239135 at CPPED1 259 1552622_s_at LOC441259 /

41315 232060 at ROR1 48544 239294 at POLR2J2 /

41471 232216 at YME1 L1 48879 239629 at CFLAR POLR2J3 /

41744 232489 at TRMT13 48992 239742 at TULP4 UPK3BL

41776 232521 at PCSK7 49143 239893 at 388 1552798 a at TLR4

41798 232543 x at ARHGAP9 49196 239946 at 560 1553043 a at CD300LF

41799 232544 at 49209 239959 x at 604 1553102 a at CCDC69

41823 232568 at MGC24103 4931 1 240061 at 667 1553186 x at RASEF

41873 232618 at TXLNG2P 49915 240665 at 1 157 1553856 s at P2RY10

41883 232628 at 50286 241036 at 1650 1554544 a at MBP

42097 232843 s at DOCK8 50882 241632 x at 1870 1554834 a at RASSF5

43198 233947 s at TBX5-AS1 50972 241722 x at 2133 1555193 a at ZNF277

44296 235046 at INPP4B 51 155 241905 at PIK3C2A 2182 1555253 at COL25A1

44388 235138 at 51371 242121 at 2591 1555812 a at ARHGDIB

44415 235165 at PARD6B 51475 242225 at 2649 1555888 at UBR5

44421 235171 at LOC100505501 51489 242239 at 2671 1555920 at CBX3

44463 235213 at ITPKB 51518 242268 at CELF2 2695 1555960 at HINT1

44492 235242 at 51641 242391 at 2732 1556009 at PEX13

44671 235421 at MAP3K8 51697 242447 at C3orf70 2745 1556035 s at ZNF207

44818 235568 at C19orf59 51789 242539 at DIS3L2 3428 1557081 at RBM25

44843 235593 at ZEB2 521 12 242862 x at 3460 1557137 at TMEM17

44920 235670 at STX1 1 52266 243016 at 3923 1557828 a at C5orf28

44948 235698 at ZFP90 52606 243356 at 4031 1558048 x at

45061 23581 1 at 52715 243465 at 4237 1558486 at ZNF493

45129 235879 at 52851 243601 at LOC285957 4354 1558693 s at C1 orf85

45329 236079 at LOC202025 53849 244598 at LCP2 4410 1558783 at

4556 1559034 at SIRPB2 10512 201063 at RCN1 11395 201946 s at CCT2

4581 1559067 a at LOC158402 10557 201108 s at THBS1 11439 201990 s at CREBL2

7502 1564164 at DENND1B 10566 201117 s at CPE 11605 202156 s at CELF2

8593 1567107 s at TPM4 10603 201154_x_at RPL4///SNORD16 11606 202157 s at CELF2

9073 1569180 at /// SNORD18A /// 11642 202193 at LIMK2

9074 1569181 x at SNORD18B /// 11651 202202 s at LAMA4

9944 200002 at RPL35 SNORD18C 11687 202238 s at NNMT

9964 200022 at RPL18 10634 201185 at HTRA1 11716 202267 at LAMC2

9978 200036 s at RPL10A 10649 201200 at CREG1 11735 202286 s at TACSTD2

10031 200089_s_at RPL4///SNORD16 10666 201217_x_at RNU86 /// RPL3 /// 11738 202289 s at TACC2

/// SNORD18A /// SNORD83B 11799 202350_s_at LOC 100506558 / SNORD18B /// 10667 201218 at CTBP2 MATN2

SNORD18C 10692 201243 s at ATP1B1 11818 202369 s at TRAM2

10109 200660 at S100A11 10717 201268_at NME1-NME2 /// 11898 202449 s at RXRA

10134 200685 at SRSF11 NME2 11907 202458 at PRSS23

10145 200696 s at GSN 10721 201272 at AKR1B1 11927 202478 at TRIB2

10154 200705_s_at EEF1B2 /// 10728 201279 s at DAB2 11928 202479 s at TRIB2

SNORA41 10729 201280 s at DAB2 11940 202491 s at IKBKAP

10179 200730 s at PTP4A1 10737 201288 at ARHGDIB 11963 202514 at DLG1

10199 200750 s at RAN 10751 201302 at ANXA4 11994 202545 at PRKCD

10214 200765 x at CTNNA1 10818 201369 s at ZFP36L2 12000 202551 s at CRIM1

10322 200873 s at CCT8 10855 201406_at RPL36A /// 12001 202552 s at CRIM1

10372 200923 at LGALS3BP RPL36A- 12004 202555 s at MYLK

10382 200933 x at RPS4X HNRNPH2 12058 202609 at EPS8

10386 200937 s at RPL5 /// SNORD21 10874 201425 at ALDH2 12113 202664 at WIPF1

10414 200965 s at ABLIM1 11014 201565 s at ID2 12210 202761 s at SYNE2

10421 200972 at TSPAN3 11015 201566 x at ID2 12245 202796 at SYNPO

10423 200974 at ACTA2 11039 201590 x at ANXA2 12272 202823 at TCEB1

10431 200982 s at ANXA6 11102 201653 at CNIH 12288 202839 s at NDUFB7

10443 200994 at IP07 11115 201666 at TIMP1 12326 202877 s at CD93

10454 201005_at CD9 /// 11169 201720 s at LAPTM5 12327 202878 s at CD93

LOC 100652804 /// 11170 201721 s at LAPTM5 12337 202888 s at ANPEP

LOC100653288 11188 201739 at SGK1 12346 202897 at SIRPA

10457 201008 s at TXNIP 11192 201743 at CD14 12367 202917 s at S100A8

10458 201009 s at TXNIP 11278 201829 at NET1 12381 202931 x at BIN1

10459 201010 s at TXNIP 11325 201876 at PON2 12383 202933 s at YES1

10461 201012 at ANXA1 11336 201887 at IL13RA1 12384 202934 at HK2

10464 201015 s at JUP 11338 201889 at FAM3C 12424 202974 at MPP1

10465 201016 at EIF1AX 11358 201909 at RPS4Y1 12491 203041 s at LAMP2

10478 201029 s at CD99 11371 201922 at NSA2 12492 203042 at LAMP2

10498 201049 s at RPS18 11387 201938_at CDK2AP1

12592 203143 s at KIAA0040 13683 204235 s at GULP1 15332 205884 at ITGA4

12634 203185 at RASSF2 13685 204237 at GULP1 15383 205935 at FOXF1

12645 203196 at ABCC4 13749 204301 at KBTBD1 1 15393 205945 at IL6R

12707 203259 s at HDDC2 13800 204352 at TRAF5 15435 205987 at CD1 C

12748 203300 x at AP1 S2 13853 204405 x at DIMT1 15445 205997 at ADAM28

12780 203332 s at INPP5D 13857 204409 s at EI F1 AY 15624 206177 s at ARG1

12827 203379 at RPS6KA1 13859 20441 1 at KI F21 B 15730 206283 s at TAL1

12836 203388 at ARRB2 13873 204425 at ARHGAP4 15742 206295 at IL18

12856 203408 s at SATB1 13893 204445 s at ALOX5 15754 206307 s at FOXD1

12918 203470 s at PLEK 13905 204457 s at GAS1 15770 206323 x at OPHN1

12919 203471 s at PLEK 13933 204485 s at TOM1 L1 15838 206391 at RARRES1

12922 203474 at IQGAP2 13950 204502 at SAMHD1 15839 206392 s at RARRES1

12956 203508 at TNFRSF1 B 14021 204573 at CROT 15867 206420 at IGSF6

12966 203518 at LYST 14067 204619 s at VCAN 15917 206470 at PLXNC1

12971 203523 at LSP1 14095 204647 at HOMER3 15935 206488 s at CD36

12976 203528 at SEMA4D 14109 204661 at CD52 16085 206638 at HTR2B

12983 203535 at S100A9 14207 204759 at RCBTB2 16157 206710 s at EPB41 L3

13041 203593 at CD2AP 14222 204774 at EVI2A 16442 206995 x at SCARF1

13080 203632 s at GPRC5B 14232 204784 s at MLF1 16448 207001 x at TSC22D3

13133 203685 at BCL2 14253 204805 s at H1 FX 16670 207224 s at SIGLEC7

13153 203705 s at FZD7 14408 204960 at PTPRCAP 16684 207238 s at PTPRC

13208 203760 s at SLA 14430 204982 at GIT2 16784 207339 s at LTB

13209 203761 at SLA 14448 205000 at DDX3Y 16862 207419 s at RAC2

13210 203762 s at DYNC2LI 1 14449 205001 s at DDX3Y 16964 207522 s at ATP2A3

13222 203774 at MTR 14464 205016 at TGFA 17013 207571 x at C1 orf38

13247 203799_at CD302 /// LY75- 14487 205039 s at IKZF1 17048 207606 s at ARHGAP12

CD302 14527 205079 s at MPDZ 17133 207691 x at ENTPD1

13258 203810 at DNAJB4 14717 205269 at LCP2 17391 207957 s at PRKCB

13294 203846 at TRIM32 14718 205270 s at LCP2 17448 208018 s at HCK

13329 203881 s at DMD 14733 205285 s at FYB 17522 208092 s at FAM49A

13370 203922 s at CYBB 14778 205330 at MN1 17550 208120_x_at FKSG49 /

13380 203932 at HLA-DMB 14824 205376 at INPP4B LOC 100506290 /

13435 203987 at FZD6 14830 205382 s at CFD LOC100653153

13483 204035 at SCG2 14865 205417 s at DAG1 17556 208127 s at SOCS5

13488 204040 at RNF144A 14919 205471 s at DACH1 17617 208190 s at LSR

13518 204070 at RARRES3 15057 205609 at ANGPT1 17706 208281 _x_at DAZ1 /// DAZ2 /

13566 2041 18 at CD48 15087 205639 at AOAH DAZ3 /// DAZ4

13598 204150 at STAB1 151 16 205668 at LY75 17733 208308 s at GPI

13624 204176 at KLHL20 15234 205786 s at ITGAM 17750 208325 s at AKAP13

13653 204205 at APOBEC3G 15255 205807 s at TUFT1 17792 208370 s at RCAN1

18040 208622 s at EZR 19015 209604 s at GATA3 20541 21 1 178 s at PSTPI P1

18054 208636 at ACTN1 19030 209619 at CD74 20598 21 1240_x_at CTNND1 /// TMX

18055 208637 x at ACTN1 19037 209626 s at OSBPL3 CTNND1

18069 208651 x at CD24 19058 209648 x at SOCS5 20634 21 1284 s at GRN

18079 208661 s at TTC3 /// TTC3P1 19092 209683 at FAM49A 20636 21 1286 x at CSF2RA

18080 208662 s at TTC3 /// TTC3P1 191 15 209706 at NKX3-1 20719 21 1382 s at TACC2

18086 208669 s at EI D1 19159 209750 at NR1 D2 20760 21 1429 s at SERPINA1

18091 208674 x at DDOST 19174 209765 at ADAM19 20823 21 1495_x_at TNFSF12 /

181 13 208697 s at EI F3E 19204 209795 at CD69 TNFSF12-

18127 20871 1 s at CCND1 19230 209823_x_at HLA-DQB1 /// TNFSF13 /

18184 208768 x at RPL22 LOC100293977 TNFSF13

18187 208771 s at LTA4H 19234 209827 s at IL16 20889 21 1563 s at URI1

18278 208862_s_at CTNND1 /// TMX2- 19236 209829 at FAM65B 20949 21 1623 s at FBL

CTNND1 19268 209861 s at METAP2 20981 21 1656_x_at HLA-DQB1 /

18307 208891 at DUSP6 19286 209879 at SELPLG LOC100293977

18308 208892 s at DUSP6 19308 209901 x at AI F1 20990 21 1666_x_at RNU86 /// RPL3 /

18309 208893 s at DUSP6 19310 209903 s at ATR SNORD83B

18345 208929_x_at RPL13 /// 19313 209906 at C3AR1 21032 21 1710_x_at RPL4 /// SNORD1

SNORD68 19396 209989 at ZNF268 /// SNORD18A /

18381 208965 s at I FI16 19541 210136 at MBP SNORD18B /

18386 208970 s at UROD 19606 210201 x at BIN1 SNORD18C

18396 208981 at PECAM1 19627 210225 x at LILRA6 /// LILRB3 21066 21 1745 x at HBA1 /// HBA2

18397 208982 at PECAM1 19714 210314 x at TNFSF13 21 1 12 21 1795 s at FYB

18413 208998 at UCP2 19826 210427 x at ANXA2 21 145 21 1828 s at TNIK

18421 209006 s at C1 orf63 19871 210473 s at GPR125 21262 21 1953 s at IP05

18496 209081 s at COL18A1 19929 210540 s at B4GALT4 21346 212039_x_at RNU86 /// RPL3 /

18568 209153 s at TCF3 SNORD83B

20030 210644 s at LAI R1

18575 209160 at AKR1 C3 21378 212071 s at SPTBN1

20051 210665 at TFPI

18604 209189 at FOS 21383 212076 at MLL

20139 210757 x at DAB2

18612 209197 at SYT1 1 21385 212078 s at MLL

20165 210784 x at LILRA6 /// LILRB3

18613 209198 s at SYT1 1 21386 212079 s at MLL

20166 210785 s at C1 orf38

18616 209201 x at CXCR4 21403 212096 s at MTUS1

20225 210844 x at CTNNA1

18645 209230 s at NUPR1 21442 212135 s at ATP2B4

20251 210875 s at ZEB1

18706 209291 at I D4 21443 212136 at ATP2B4

20283 210915 x at TRBC1

18710 209295 at TNFRSF10B 21494 212187 x at PTGDS

20361 210993 s at SMAD1

18713 209298 s at ITSN1 21495 212188 at KCTD12

20438 21 1073_x_at RNU86 /// RPL3 ///

18722 209307 at SWAP70 SNORD83B 21498 212191_x_at RPL13 /

SNORD68

18861 209447 at SYNE1 20498 21 1 133 x at LILRA6 /// LILRB3

21542 212235 at PLXND1

18888 209474 s at ENTPD1 20499 21 1 135 x at LILRA6 /// LILRB3

21620 212314 at SEL1 L3

18915 209501 at CDR2 20523 21 1 160 x at ACTN1

21678 212372 at MYH10

21692 212386 at TCF4 22854 213552 at GLCE 25025 215731 s at MPHOSPH9

21693 212387 at TCF4 22894 213593 s at TRA2A 25079 215785 s at CYFI P2

21703 212397 at RDX 22904 213603 s at RAC2 25256 215963 x at RPL3

21732 212426 s at YWHAQ 22919 213618 at ARAP2 25325 216032 s at ERGIC3

21760 212454 x at HNRPDL 22939 213638 at PHACTR1 25334 216041 x at GRN

21764 212458 at SPRED2 22978 213677 s at PMS1 25353 216060 s at DAAM1

21787 212481 s at TPM4 23027 213726 x at TUBB4B 25504 21621 1 at

21806 212500 at ADO 23165 213864 s at NAP1 L1 25634 216342 x at

21844 212538 at DOCK9 23231 213931 at I D2 /// I D2B 26264 216973 s at HOXB7

21893 212587 s at PTPRC 23275 213975 s at LYZ 26452 217164 at

21894 212588 at PTPRC 23342 214042 s at RPL22 26490 217202 s at GLUL

21912 212606 at WDFY3 23354 214054 at DOK2 26700 217414 x at HBA1 /// HBA2

21977 212671_s_at HLA-DQA1 /// 23402 214102 at 26835 217549 at

HLA-DQA2 /// 23481 214181 x at LST1 27038 217752 s at CNDP2

LOC100507718 /// 2351 1 21421 1 at FTH1 27093 217807 s at GLTSCR2 LOC100509457 23518 214218 s at XIST 27175 217889 s at CYBRD1

21987 212681 at EPB41 L3 23539 214239 x at PCGF2 27318 218032 at SNN

21998 212692 s at LRBA 23580 214280 x at HNRNPA1 27321 218035 s at RBM47

22040 212734_x_at RPL13 /// 23590 214290_s_at HIST2H2AA3 /// 27446 218160 at NDUFA8

SNORD68 HIST2H2AA4 27458 218172 s at DERL1

22130 212824 at FUBP3 23651 214351_x_at RPL13 /// 27486 218200 s at NDUFB2

22136 212830 at MEGF9 SNORD68 27503 218217 at SCPEP1

22137 212831 at MEGF9 23714 214414 x at HBA1 /// HBA2 27509 218223 s at PLEKH01

22179 212873 at HMHA1 23755 214455_at HIST1 H2BC /// 27523 218237 s at SLC38A1

22192 212886 at CCDC69 HIST1 H2BE /// 27525 218239 s at GTPBP4

22238 212933_x_at RPL13 /// HIST1 H2BF /// 27539 218253 s at EIF2D

SNORD68 HIST1 H2BG /// 27575 218289 s at UBA5

22302 212998_x_at HLA-DQB1 /// HIST1 H2BI 27740 218454 at PLBD1

LOC100293977 2381 1 21451 1 x at FCGR1 B 27845 218559 s at MAFB

22340 213036 x at ATP2A3 23978 214681 at GK 27923 218638_s_at LOC100130872 /

22432 213128 s at UBE3A 24002 214705 at INADL SPON2

22439 213135 at TIAM1 24043 214746 s at ZNF467 27945 218660 at DYSF

22456 213152 s at SRSF8 24249 214953 s at APP 27991 218706 s at GRAMD3

22564 213262 at SACS 24297 215001 s at GLUL 27997 218712 at C1 orf109

22661 213359 at HNRNPD 24442 215147 at 28091 218806 s at VAV3

22679 213377 x at RPS12 24466 215171 s at TIMM17A 28092 218807 at VAV3

22700 213398 s at SDR39U1 24472 215177 s at ITGA6 281 14 218829 s at CHD7

22718 213416 at ITGA4 24602 215307 at ZNF529 281 16 218831 s at FCGRT

22780 213478 at KAZN 24876 215582 x at MCM3AP 28141 218856 at TNFRSF21

22805 213503 x at ANXA2 24893 215599_at GUSBP3 /// 28155 218870 at ARHGAP15

22841 213539 at CD3D GUSBP9

28217 218932 at ZNHIT6 30343 221059 s at COTL1 32581 223303 at FERMT3

28252 218967 s at PTER 30344 221060 s at TLR4 32596 223318 s at ALKBH7

28299 219014 at PLAC8 30440 221 156 x at CCPG1 32600 223322 at RASSF5

28302 219017 at ETNK1 30525 221241 s at BCL2L14 32618 223340 at ATL1

28318 219033 at PARP8 30529 221245 s at FZD5 32636 223358 s at PDE7A

28384 219099 at C12orf5 30769 221485 at B4GALT5 32701 223423 at GPR160

28394 219109 at SPAG16 30876 221593 s at RPL31 3271 1 223433 at YAE1 D1

28402 2191 17 s at FKBP1 1 30884 221601 s at FAIM3 32741 223463 at RAB23

28415 219130 at TRMT13 30885 221602 s at FAIM3 32812 223535 at NUDT12

28459 219174 at I FT74 30973 221691 x at NPM1 32829 223552 at LRRC4

28476 219191 s at BIN2 31007 221726 at RPL22 32839 223562 at PARVG

28528 219243 at GIMAP4 31009 221728 x at XIST 32854 223577 x at MALAT1

28600 219315 s at TMEM204 31012 221731 x at VCAN 32891 223614 at MMP16

28620 219335 at ARMCX5 31046 221765 at UGCG 32917 223640 at HCST

28836 219551 at EAF2 31049 221768 at SFPQ 32923 223646 s at TXLNG2P

28848 219563 at LINC00341 31056 221775 x at RPL22 33028 223751 x at TLR10

28892 219607 s at MS4A4A 31083 221802 s at KIAA1598 33321 224046 s at PDE7A

28939 219654 at PTPLA 31 121 221840 at PTPRE 33523 224252 s at FXYD5

28966 219681 s at RAB1 1 FI P1 31 141 221860 at HNRNPL 33557 224288 x at FKSG49

28999 219714 s at CACNA2D3 31 153 221872 at RARRES1 33578 224309 s at SUGT1

29022 219737 s at PCDH9 31 160 221879 at CALML4 33609 224341 x at TLR4

29047 219762 s at RPL36 31 165 221884 at MECOM 33631 224364 s at PPIL3

29082 219797 at MGAT4A 31 180 221899 at N4BP2L2 33742 224480 s at AGPAT9

29170 219885 at SLFN12 31297 222016 s at ZNF323 33778 224516 s at CXXC5

29377 220092 s at ANTXR1 31305 222024 s at AKAP13 33819 224559_ _at LOC100507645 /

29452 220167_s_at LOC729264 /// 31321 222040 at HNRNPA1 MALAT1

TP53TG3 /// 31435 222154 s at SPATS2L 33839 224579 at SLC38A1 TP53TG3B /// 31733 222453 at CYBRD1 33840 224580 at SLC38A1 TP53TG3C 31770 222490 at POLR3E 33848 224588 at XIST

29472 220187 at STEAP4 31776 222496 s at RBM47 33849 224589 at XIST

29517 220232 at SCD5 31942 222662 at PPP1 R3B 33850 224590 at XIST

29805 220520 s at NUP62CL 31972 222692 s at FNDC3B 33945 224685 at MLLT4

29813 220528 at VNN3 32022 222742 s at RABL5 34061 224802 at NDFIP2

29888 220603 s at MCTP2 32065 222785 x at C1 1 orf1 34082 224823 at MYLK

29900 220615 s at FAR2 32078 222798 at PTER 34100 224841 _ _x_at GAS5 /

30010 220725 x at DNAH3 32280 223000 s at F1 1 R SNORD44 /

30040 220755 s at C6orf48 32415 223136 at AIG1 SNORD47 /

301 17 220832 at TLR8 32435 223156 at MRPS23 SNORD76 /

30245 220960 x at RPL22 32527 223249 at CLDN12 SNORD77 /

30284 220999 s at CYFIP2 32554 223276 at C5orf62 SNORD79 /

SNORD80 /

SNORD81 35260 226003 at KI F21 A 36290 227034 at SOWAHC

341 15 224856 at FKBP5 35379 226122 at PLEKHG1 36315 227059 at GPC6

34120 224861 at GNAQ 35452 226195 at I FT43 36330 227074 at LOC100131564

34165 224906 at AN06 35476 226219 at ARHGAP30 36379 227123 at RAB3B

34176 224917 at MIR21 35504 226247 at PLEKHA1 36390 227134 at SYTL1

34209 224950 at PTGFRN 3551 1 226254 s at KIAA1430 36424 227168 at MIAT

34226 224967 at UGCG 35547 226290 at BDP1 36429 227173 s at BACH2

34260 225001 at RAB3D 35575 226318 at TBRG1 36434 227178 at CELF2

34290 225032 at FNDC3B 35590 226333 at IL6R 36466 227210 at SFMBT2

34309 225051 at EPB41 35594 226337 at GORAB 36479 227223 at RBM39

34318 225060 at LRP1 1 35609 226352 at JMY 36521 227265 at FGL2

34394 225136 at PLEKHA2 35621 226364 at HI P1 36522 227266 s at FYB

34402 225144 at BMPR2 35622 226365 at 36597 227341 at BEND7

34420 225162 at SH3D19 35701 226444 at 36602 227346 at IKZF1

34465 225207 at PDK4 35764 226507 at PAK1 36617 227361 at HS3ST3B1

34478 225220 at SNHG8 35807 226550 at SLC9A7 36626 227370 at FAM171 B

34583 225325 at MFSD6 35815 226558_at LOC389834 /// 36718 227462 at ERAP2

34586 225328 at FBX032 MAFI P /// 36734 227478 at SETBP1

34622 225364 at STK4 TEKT4P2 36737 227481 at CNKSR3

34630 225372 at C10orf54 35844 226587 at LOC100506965 36803 227548 at ORMDL1

34631 225373 at C10orf54 35897 226641 at ANKRD44 36902 227647 at KCNE3

34715 225457_s_at LINC00263 /// 35915 226659 at DEF6 36981 227726 at RNF166

PP7080 35921 226665 at AHSA2 36997 227742 at CLIC6

34760 225502 at DOCK8 35933 226677 at ZNF521 37066 22781 1 at FGD3

34805 225547_at SNHG6 /// 36020 226764 at ZNF827 37130 227875 at KLHL13

SNORD87 36029 226773 at 37139 227884 at TAF15

34837 225579 at PQLC3 36066 226810 at OGFRL1 37184 227929 at LIN7A

34870 225612_s_at B3GNT5 /// 36093 226837 at SPRED1 37203 227948 at FGD4

LOC100505668 36103 226847 at FST 37301 228046 at ZNF827

34880 225622 at PAG1 36104 226848 at 37310 228055 at NAPSB

34923 225665 at ZAK 36121 226865 at LOC100509635 37353 228098 s at MYLI P

34993 225735 at ANKRD50 36123 226867 at DENND4C 37410 228155 at FAM213A

35052 225794 s at C22orf32 36125 226869 at MEGF6 37412 228157 at ZNF207

35053 225795 at C22orf32 36131 226875 at DOCK1 1 37422 228167 at KLHL6

35061 225803 at FBX032 36136 226880 at NUCKS1 37443 228188 at FOSL2

35093 225835 at SLC12A2 36150 226894 at SLC35A3 37513 228258 at TBC1 D10C

35125 225867 at VASN 36190 226934 at CPSF6 37521 228266 s at HDGFRP3

35143 225885 at EEA1 36245 226989 at RGMB 37539 228284 at TLE1

35155 225897 at MARCKS 36257 227001 at NI PAL2 37600 228345 at CHIC1

35185 225927 at MAP3K1 36258 227002 at FAM78A 37652 228397 at TUG1

37663 228408 s at SDAD1 39355 230100 x at PAK1 43590 234339 s at GLTSCR2

37710 228455 at 39516 230261 at ST8SIA4 43925 234675 x at

37726 228471 at ANKRD44 39638 230383 x at 44199 234949 at FRG1 B

37787 228532 at C1 orf162 39644 230389 at FNBP1 44259 235009 at BOD1 L1

37832 228577 x at ODF2L 39968 230713 at 44273 235023 at VPS13C

37837 228582 x at MALAT1 39988 230733 at 44278 235028 at

37873 228618 at PEAR1 39990 230735 at 44298 235048 at FAM169A

37879 228624 at TMEM144 40043 230788 at GCNT2 44310 235060 at LOC100190986

37913 228658 at Ml AT 40284 231029 at F5 44318 235068 at ZDHHC21

37961 228706 s at CLDN23 40348 231093 at FCRL3 44344 235094 at

37971 228716 at THRB 40454 231 199 at 44392 235142 at ZBTB8A

38015 228760 at SRSF8 40899 231644 at 44396 235146 at TMCC3

38048 228793 at JMJD1 C 41030 231775 at TNFRSF10A 44635 235385 at MARCH1

38056 228801 at ORMDL1 41053 231798 at NOG 44672 235422 at

38096 228841 at LYRM7 41 184 231929 at IKZF2 44779 235529 x at SAMHD1

38241 228986 at OSBPL8 41202 231947 at MYCT1 44827 235577 at ZNF652

38296 229041 s at LOC100505746 41244 231989_s_at 61 E3.4 /// 44901 235651 at TTC22

38350 229095_s_at LIMS3 /// LIMS3- LOC100132247 /// 44943 235693 at

LOC440895 /// LOC100271836 /// 45176 235926 at ANAPC5 LIMS3L /// LOC 100652992 /// 45214 235964 x at SAMHD1 LOC 100288570 /// LOC613037 /// 45250 236000 s at

LOC 100507334 /// LOC728888 /// 45257 236007 at AKAP10 LOC440895 NPI PL3 /// 45448 236198 at

38366 2291 1 1 at SLC7A5P1 /// 45504 236254 at VPS13B

38524 229269 x at SSBP4 SMG1 P1 45515 236265 at SP4

38550 229295 at IL17RA 41255 232000 at 45530 236280 at

38572 229317 at KPNA5 41289 232034 at LINC00537 45946 236696 at U2SURP

38689 229434 at 41335 232080 at HECW2 46091 236841 at LOC100134445

38738 229483 at 41377 232122 s at VEPH1 46106 236856 x at

38815 229560 at TLR8 41393 232138 at MBNL2 46572 237322 at MIAT

38818 229563 s at RPL10A 41486 232231 at RUNX2 47279 238029 s at SLC16A14

38829 229574 at TRA2A 41566 23231 1 at B2M 47406 238156 at

38880 229625 at GBP5 4161 1 232356 at 47680 238430 x at SLFN5

38884 229629 at 41686 232431 at NR3C1 47689 238439 at ANKRD22

38949 229694 at WDR1 1 42168 232914 s at SYTL2 47699 238449 at LOC595101

39014 229759 s at VEPH1 42472 233219 at 47770 238520 at TRERF1

39020 229765 at ZNF207 42762 233510 s at PARVG 47951 238701 x at C1 1 orf92

39065 229810 at 42927 233675 s at TPTE2P6 48143 238893 at LOC338758

39207 229952 at 43064 233813 at PPP1 R16B 48299 239049 at

39324 230069 at SFXN1 43100 233849 s at ARHGAP5 48358 239108 at

43402 234151 at

Probe* Set.lD** Gene. Symbol Probe* Set.lD** Gene. Symbol

48425 239175 at 52428 243178 at

48522 239272 at MMP28 52502 243252 at

48586 239336 at THBS1 52559 243309 at FLJ27352

48643 239393 at 52645 243395 at

48659 239409 at 52746 243496 at RAB18

48847 239597 at 52759 243509 at

49355 240105 at 53018 243768 at

49557 240307 at 53242 243992 at

49564 240314 at 53365 2441 14 x at

49633 240383 at UBE2D3 53592 244341 at

50238 240988 x at 53684 244433 at

50318 241068 at 53783 244532 x at

50675 241425 at NUPL1 53905 244654 at MY01 G

51036 241786 at 53920 244669_at SNORD50A ///

51074 241824 at SNORD50B

51 141 241891 at 54196 34031 i at KRIT1

51244 241994 at XDH 54200 34210 at CD52

51307 242057 at 54355 40420 at STK10

51318 242068 at 54383 41577 at PPP1 R16B

51343 242093 at SYTL5 54451 49306 at RASSF4

51360 2421 10 at 54527 58780 s at ARHGEF40

51396 242146 at SNRPA1 54561 64432 at MAPKAPK5-AS1

5151 1 242261 at I REB2 probe number in the microarray

51593 242343 x at

51602 242352 at NI PBL Affymetrix U133 Plus 2.0

51639 242389 at LUC7L3

51679 242429 at ZNF567 ^** : Set.lD in the microarray Affymetrix

51688 242438 at ASXL1 U133 Plus 2.0

51923 242673 at

51962 242712_x_at RGPD3 /// RGPD4

/// RGPD5 ///

RGPD6 /// RGPD8

51977 242727 at ARL5B

52024 242774 at SYNE2

52064 242814 at SERPINB9

52153 242903 at I FNGR1

52193 242943 at ST8SIA4

52196 242946 at CD53

52224 242974 at CD47

52359 243109 at MCTP2

Table 4: Alternative list of analyzed genes Probe* Set.lD** Gene.Symbol Probe* Set.lD** Gene.Symbol

2371 1555497 a at CYP4B1 8966 1568964 x at SPN

Probe* Set.lD** Gene.Symbol 2450 1555613 a at ZAP70 9163 1569344 a at

3 1 17 at HSPA6 2467 1555638 a at SAMSN1 9349 1569652 at MLLT3

9 1405 i at CCL5 2501 1555691_a_at KLRC4-KLRK1 /// 10400 200951 s at CCND2

62 1552326 a at CCDC1 1 KLRK1 10402 200953 s at CCND2

83 1552365 at SCIN 2529 1555731 a at AP1 S3 10491 201042 at TGM2

84 1552367 a at SCIN 2549 1555756 a at CLEC7A 10507 201058 s at MYL9

91 1552378 s at RDH10 2552 1555759 a at CCL5 10567 201 1 18 at PGD

155 1552477 a at IRF6 2565 1555778 a at POSTN 10580 201 131 s at CDH1

174 1552502 s at RHBDL2 2566 1555779 a at CD79A 10596 201 147 s at TIMP3

209 1552553 a at NLRC4 2723 1555997 s at IGFBP5 10598 201 149 s at TIMP3

231 1552584 at IL12RB1 2727 1556003 a at LOC100506777 10599 201 150 s at TIMP3

238 1552594 at TMEM190 2746 1556037 s at HHI P 10691 201242 s at ATP1 B1

270 1552634 a at ZNF101 2840 1556185 a at STEAP4 10735 201286 at SDC1

364 1552767 a at HS6ST2 2857 1556209 at CLEC2B 10736 201287 s at SDC1

387 1552797 s at PROM2 2916 1556300 s at SIM1 10836 201387 s at UCHL1

394 1552806 a at SIGLEC10 3053 1556499 s at COL1 A1 10887 201438 at COL6A3

395 1552807 a at SIGLEC10 3109 1556601 a at SPATA13 10959 201510 at ELF3

606 1553105 s at DSG2 3145 1556657 at 1 1027 201578 at PODXL

616 15531 18 at THEM4 3427 1557080 s at ITGBL1 1 1099 201650 at KRT19

660 1553177 at SH2D1 B 3779 1557636 a at C7orf57 1 1 104 201655 s at HSPG2

748 1553297 a at CSF3R 4054 15581 1 1 at MBNL1 1 1 193 201744 s at LUM

841 1553423 a at SLFN13 4108 1558217 at SLFN13 1 1234 201785 at RNASE1

977 1553589 a at PDZK1 IP1 4334 1558662 s at BANK1 1 1269 201820 at KRT5

989 1553605 a at ABCA13 4522 1558971 at THEMIS 1 1288 201839 s at EPCAM

994 1553613 s at FOXC1 4523 1558972 s at THEMIS 1 1292 201843 s at EFEMP1

1039 1553681 a at PRF1 4587 1559078 at 1 1302 201853 s at CDC25B

1081 1553734 at AK7 4728 1559333 at SRGAP3-AS2 1 1333 201884 at CEACAM5

1249 1553986 at RASEF 4758 1559391 s at 1 1342 201893 x at DCN

1353 1554140 at WDR78 4778 1559425 at 1 1412 201963 at ACSL1

1425 1554240 a at ITGAL 4876 1559584 a at C16orf54 1 1454 202005 at ST14

1432 1554250 s at TRIM73 5325 1560396 at KLHL6 1 1467 202018 s at LTF

1502 1554343 a at STAP1 5326 1560397 s at KLHL6 1 1532 202083 s at SEC14L1

1546 1554406 a at CLEC7A 6651 1562529 s at 1 1561 2021 12 at VWF

1681 1554588 a at TTC30B 7017 1563075 s at 1 1655 202206 at ARL4C

1745 1554676 at SRGN 7029 1563088 a at LOC284837 1 1656 202207 at ARL4C

1794 1554741_s_at FGF7 /// KGFLP1 /// 7316 1563674 at FCRL2 1 1657 202208 s at ARL4C

KGFLP2 8086 1565913 at 1 1690 202241 at TRIB1

21 13 1555167 s at NAMPT 8251 1566342 at 1 1759 202310 s at COL1 A1

2150 1555214 a at CLEC7A 8716 1567913 at 1 1760 20231 1 s at COL1 A1

2263 1555355 a at ETS1

1 1790 202341 s at TRIM2 12704 203256 at CDH3 13640 204192 at CD37

1 1791 202342 s at TRIM2 12738 203290 at HLA-DQA1 13645 204197 s at RUNX3

1 1806 202357 s at CFB 12835 203387 s at TBC1 D4 13646 204198 s at RUNX3

1 1837 202388 at RGS2 12845 203397 s at GALNT3 13716 204268 at S100A2

1 1840 202391 at BASP1 12855 203407 at PPL 13752 204304 s at PROM1

1 1852 202403 s at COL1 A2 12861 203413_at LOC100653018 /// 13827 204379 s at FGFR3

1 1853 202404 s at COL1 A2 LOC 100653255 /// 13837 204389 at MAOA

1 1903 202454 s at ERBB3 NELL2 13841 204393 s at ACPP

1 1938 202489 s at FXYD3 12872 203424 s at IGFBP5 13903 204455_at DST /

1 1946 202497 x at SLC2A3 12901 203453 at SCNN1 A LOC100652766

1 1947 202498 s at SLC2A3 12933 203485 at RTN1 13914 204466 s at SNCA

1 1948 202499 s at SLC2A3 12957 203509 at SORL1 13916 204468 s at TI E1

1 1953 202504 at TRIM29 13009 203561 at FCGR2A 13917 204469 at PTPRZ1

1 1973 202524 s at SPOCK2 13022 203574 at NFIL3 13920 204472 at GEM

1 1974 202525 at PRSS8 13039 203591 s at CSF3R 14000 204552 at INPP4A

12074 202625 at LYN 13093 203645 s at CD163 14029 204581 at CD22

12075 202626 s at LYN 13154 203706 s at FZD7 14036 204588 s at SLC7A7

12190 202741 at PRKACB 13174 203726 s at LAM A3 14043 204595 s at STC1

12191 202742 s at PRKACB 13195 203747 at AQP3 14044 204596 s at STC1

12197 202748 at GBP2 13205 203757 s at CEACAM6 14045 204597 x at STC1

12239 202790 at CLDN7 13213 203765 at GCA 14101 204653 at TFAP2A

12275 202826 at SPINT1 13272 203824 at TSPAN8 14103 204655 at CCL5

12280 202831 at GPX2 13276 203828 s at IL32 141 15 204667 at FOXA1

12339 202890 at MAP7 13337 203889 at SCG5 14125 204677 at CDH5

12360 202910 s at CD97 13340 203892 at WFDC2 14127 204679 at KCNK1

12397 202947 s at GYPC 13358 203910 at ARHGAP29 14129 204681 s at RAPGEF5

12421 202971 s at DYRK2 13365 203917 at CXADR 14131 204683 at ICAM2

12438 202988 s at RGS1 13369 203921 at CHST2 14179 204731 at TGFBR3

12440 202990 at PYGL 13382 203934 at KDR 14182 204734 at KRT15

12471 203021 at SLPI 13384 203936 s at MMP9 14198 204750 s at DSC2

12495 203045 at NINJ1 13401 203953 s at CLDN3 14225 204777 s at MAL

12524 203074_at ANXA8 /// ANXA8L1 13410 203962 s at NEBL 14241 204793 at GPRASP1

/// ANXA8L2 13454 204006_s_at FCGR3A /// 14242 204794 at DUSP2

12533 203083 at THBS2 FCGR3B 14250 204802 at RRAD

12572 203123 s at SLC1 1 A2 13455 204007 at FCGR3B 14251 204803 s at RRAD

12575 203126 at IMPA2 13520 204072 s at FRY 14259 20481 1 s at CACNA2D2

12580 203131 at PDGFRA 13564 2041 16 at IL2RG 14269 204821 at BTN3A3

12589 203140 at BCL6 13608 204160 s at ENPP4 14294 204846 at CP

12629 203180 at ALDH1 A3 13609 204161 s at ENPP4 14303 204855 at SERPINB5

12673 203224 at RFK 13622 204174 at ALOX5AP 14338 204890 s at LCK

14380 204932 at TNFRSF1 1 B 14980 205532 s at CDH6 15546 206099 at PRKCH

14381 204933 s at TNFRSF1 1 B 14992 205544 s at CR2 15558 2061 1 1 at RNASE2

14397 204949 at ICAM3 14995 205547 s at TAGLN 15565 2061 18 at STAT4

NCF1 C 15038 205590 at RASGRP1 15597 206150 at CD27

14462 205014 at FGFBP1 15043 205595 at DSG3 15604 206157 at PTX3

14489 205041 s at ORM1 /// ORM2 15045 205597 at SLC44A4 1561 1 206164 at CLCA2

14492 205044 at GABRP 15060 205612 at MMRN1 15612 206165 s at CLCA2

14497 205049 s at CD79A 15071 205623 at ALDH3A1 15613 206166 s at CLCA2

14512 205064 at SPRR1 B 151 19 205671 s at HLA-DOB 15618 206171 at ADORA3

14516 205068 s at ARHGAP26 15129 205681 at BCL2A1 15619 206172 at IL13RA2

14567 2051 19 s at FPR1 15157 205709 s at CDS1 15644 206197 at NME5

14595 205147 x at NCF4 15173 205725 at SCGB1 A1 15653 206206 at CD180

14605 205157 s at JUP /// KRT17 15206 205758 at CD8A 15654 206207 at CLC

14607 205159 at CSF2RB 15213 205765 at CYP3A5 15669 206222 at TNFRSF10C

14619 205171 at PTPN4 15216 205768 s at SLC27A2 15691 206244 at CR1

14622 205174 s at QPCT 15217 205769 at SLC27A2 15723 206276 at LY6D

14628 205180 s at ADAM8 15228 205780 at BIK 15771 206324 s at DAPK2

14633 205185 at SPINK5 15238 205790 at SKAP1 15778 206331 at CALCRL

14634 205186 at DNALI1 15246 205798 at IL7R 15810 206363 at MAF

14638 205190 at PLS1 15269 205821_at KLRC4-KLRK1 /// 15813 206366 x at XCL1

14661 205213 at ACAP1 KLRK1 15824 206377 at FOXF2

14662 205214 at STK17B 15276 205828 at MMP3 15845 206398 s at CD19

14668 205220 at HCAR3 15279 205831 at CD2 15847 206400_at LGALS7 /

14715 205267 at POU2AF1 15294 205846 at PTPRB LGALS7B

14739 205291 at IL2RB 15331 205883 at ZBTB16 1591 1 206464 at BMX

14745 205297 s at CD79B 15336 205888 s at JAKMIP2 15925 206478 at KIAA0125

14767 205319 at PSCA 15338 205890 s at GABBR1 /// UBD 15928 206481 s at LDB2

14776 205328 at CLDN10 15346 205898 at CX3CR1 15962 206515 at CYP4F3

14851 205403 at IL1 R2 15347 205899 at CCNA1 15969 206522 at MGAM

14870 205422 s at ITGBL1 15349 205901 at PNOC 15992 206545 at CD28

14882 205434 s at AAK1 15364 205916 at S100A7 16008 206561 s at AKR1 B10

14904 205456 at CD3E 15370 205922 at VNN2 16031 206584 at LY96

14918 205470 s at KLK1 1 15372 205924 at RAB3B 16042 206595 at CST6

14924 205476 at CCL20 15427 205979 at SCGB2A1 16078 206631 at PTGER2

14936 205488 at GZMA 15438 205990 s at WNT5A 16084 206637 at P2RY14

14943 205495 s at GNLY 15476 206028 s at MERTK 16090 206643 at HAL

14949 205501 at PDE10A 15480 206032 at DSC3 161 13 206666 at GZMK

14961 205513 at TCN1 15481 206033 s at DSC3 16123 206676 at CEACAM8

14976 205528 s at RUNX1 T1 15506 206059 at ZNF91 16130 206683 at ZNF165

16154 206707 x at FAM65B 17907 208488 s at CR1 19200 209791 at PADI2

16208 206761 at CD96 17958 208539 x at SPRR2B 19201 209792 s at KLK10

16251 206804 at CD3G SAA2-SAA4 19222 209815 at PTCH1

16361 206914 at CRTAM 18431 209016 s at KRT7 19270 209863 s at TP63

16371 206924 at IL1 1 18485 209070 s at RGS5 19271 209864 at FRAT2

16425 206978 at CCR2 18486 209071 s at RGS5 19278 209871 s at APBA2

16430 206983 at CCR6 18502 209087 x at MCAM 19288 209881 s at LAT

16455 207008 at CXCR2 18529 2091 14 at TSPAN1 19301 209894 at LEPR

16465 207018 s at RAB27B 18535 209120 at NR2F2 19312 209905_at HOXA10-HOXA9 /

16519 207072 at IL18RAP 18536 209121 x at NR2F2 HOXA9

16523 207076 s at ASS1 18540 209125 at KRT6A 19332 209925 at OCLN

16541 207094 at CXCR1 18541 209126 x at KRT6B 19337 209930 s at NFE2

16558 2071 1 1 at EMR1 18553 209138 x at IGLC1 19353 209946 at VEGFC

16616 207169 x at DDR1 /// MIR4640 18574 209159 s at NDRG4 19356 209949 at NCF2

16624 207178 s at FRK 18588 209173 at AGR2 19362 209955 s at FAP

16721 207275 s at ACSL1 18594 209179 s at MBOAT7 19400 209993 at ABCB1

16737 207291 at PRRG4 18599 209184 s at I RS2 19402 209995 s at TCL1 A

16758 207313_x_at KIR3DL1 /// 18600 209185 s at I RS2 19432 210026 s at CARD10

KIR3DL2 /// 18615 209200 at MEF2C 19437 210031 at CD247

LOC727787 18626 20921 1 at KLF5 19444 210038 at PRKCQ

16773 207328 at ALOX15 18627 209212 s at KLF5 19445 210039 s at PRKCQ

16795 207351 s at SH2D2A 18704 209289 at NFIB 19470 210064 s at UPK1 B

16873 207430 s at MSMB 18705 209290 s at NFIB 19471 210065 s at UPK1 B

16912 207469 s at PIR 18749 209335 at DCN 19501 210096 at CYP4B1

16952 207509 s at LAIR2 18765 209351 at KRT14 19510 210105 s at FYN

17052 207610 s at EMR2 18782 209368 at EPHX2 19522 2101 17 at SPAG1

17093 207651 at GPR171 18788 209374 s at IGHM 19524 2101 19 at KCNJ15

17097 207655 s at BLNK 18809 209395 at CHI3L1 19545 210140 at CST7

171 19 207677 s at NCF4 18810 209396 s at CHI3L1 19569 210164 at GZMB

17165 207723 s at KLRC3 18820 209406 at BAG2 19581 210176 at TLR1

17237 207795 s at KLRD1 18943 209529 at PPAP2C 19589 210184 at ITGAX

17244 207802 at CRISP3 18953 209539 at ARHGEF6 19624 210222 s at RTN1

17259 207819 s at ABCB4 18993 209582 s at CD200 19645 210244 at CAMP

17287 207847 s at MUC1 19080 209670 at TRAC 19698 210297 s at MSMB

17372 207935 s at KRT13 19081 209671 x at TRAC 19721 210321 at GZMH

1741 1 207979 s at CD8B 19095 209686 at S100B 19747 210347 s at BCL1 1 A

17693 208268 at ADAM28 19128 209719 x at SERPINB3 19755 210356 x at MS4A1

17869 208450_at LGALS2 19129 209720 s at SERPINB3 19796 210397 at DEFB1

19812 210413_x_at SERPINB3 /// IGHA2 /// IGHD /// 22398 213094 at GPR126

SERPINB4 IGHG1 /// IGHG3 /// 22413 213109 at TNIK

19821 210422 x at SLC1 1 A1 IGHG4 /// IGHM /// 22475 213172 at TTC9

19825 210426 x at RORA IGHV3-23 /// IGHV4- 22543 213240 s at KRT4

19847 210448 s at P2RX5 31 22544 213241 at PLXNC1

19881 210484_s_at LOC254896 /// 20970 21 1645 x at 22587 213285 at TMEM30B

TNFRSF10C 20982 21 1657 at CEACAM6 22640 213338 at TMEM158

19897 210505 at ADH7 21007 21 1685 s at NCALD 22694 213392 at IQCK

19992 210606 x at KLRD1 21009 21 1687 x at KI R3DL1 22720 213418 at HSPA6

20098 210715 s at SPINT2 21055 21 1734 s at FCER1 A 22727 213425 at WNT5A

20131 210749 x at DDR1 /// MIR4640 21 123 21 1806 s at KCNJ15 22777 213475 s at ITGAL

20136 210754 s at LYN 21 130 21 1813 x at DCN 22836 213534 s at PASK

20154 210772 at FPR2 21205 21 1896 s at DCN 22843 213541 s at ERG

20155 210773 s at FPR2 2121 1 21 1902 x at YME1 L1 22912 21361 1 at AQP5

20208 210827 s at ELF3 21215 21 1906 s at SERPINB4 22921 213620 s at ICAM2

20228 210847 x at TNFRSF25 21231 21 1922 s at CAT 22975 213674 x at IGHD

20270 210895 s at CD86 21267 21 1959 at IGFBP5 22980 213679 at TTC30A

20340 210972_x_at TRAC /// TRAJ17 /// 21377 212070 at GPR56 22981 213680 at KRT6B

TRAV20 21543 212236 x at JUP /// KRT17 22994 213693 s at MUC1

20360 210992 x at FCGR2C 21546 212239 at PIK3R1 23038 213737 x at GOLGA8IP

20373 21 1005 at LAT 21547 212240 s at PIK3R1 23097 213796 at SPRR1 A

20526 21 1 163 s at TNFRSF10C 21617 21231 1 at SEL1 L3 23131 213830 at YME1 L1

20554 21 1 192 s at CD84 21638 212332 at RBL2 23150 213849 s at PPP2R2B

20625 21 1272 s at DGKA 21660 212354 at SULF1 23206 213906 at MYBL1

20646 21 1302 s at PDE4B 21666 212360 at AMPD2 23208 213908_at WHAMMP2 /

20678 21 1339 s at ITK 21792 212486 s at FYN WHAMMP3

20679 21 1340 s at MCAM 21807 212501 at CEBPB 23215 213915 at NKG7

20698 21 1361 s at SERPINB13 21837 212531 at LCN2 23229 213929 at EXPH5

20709 21 1372 s at IL1 R2 21905 212599 at AUTS2 23254 213954 at FAM169A

20731 21 1395 x at FCGR2C 21944 212638 s at WWP1 23332 214032 at ZAP70

20845 21 1518 s at BMP4 22126 212820 at DMXL2 23349 214049 x at CD7

20859 21 1532_x_at KIR2DS1 /// 22133 212827 at IGHM 23361 214061 at WDR67

KIR2DS2 /// 22135 212829 at PI P4K2A 23370 214070 s at ATP10B

KIR2DS3 /// 22149 212843 at NCAM1 23371 214071 at GNAL

KIR2DS4 /// 22214 212909 at LYPD1 23483 214183 s at TKTL1

KIR2DS5 /// 22246 212942 s at KIAA1 199 23540 214240 at GAL

KIR3DL3 22279 212975 at DENND3 23738 2 4438 at HLX

20923 21 1597 s at HOPX 22333 213029 at NFIB 23750 214450 at CTSW

20962 21 1637 x at IGH@ /// IGHA1 ///

23756 214456 x at SAA1 /// SAA2 25239 215945 s at TRIM2 27754 218468 s at GREM1

23770 214470 at KLRB1 25283 215990 s at BCL6 27755 218469 at GREM1

23849 214549 x at SPRR1 A 25326 216033 s at FYN 27787 218501 at ARHGEF3

23867 214567 s at XCL1 /// XCL2 25484 216191 s at TRDV3 27796 218510 x at FAM134B

23879 214580_x_at KRT6A /// KRT6B /// 25500 216207 x at IGKC /// LOC642838 27818 218532 s at FAM134B

KRT6C 25545 216252 x at FAS 27900 218614 at C12orf35

23881 214582 at PDE3B 25693 216401 x at 27962 218677 at S100A14

23916 214617 at PRF1 25783 216491 x at IGHM 27972 218687 s at MUC13

23950 214651_s_at HOXA10-HOXA9 /// 25867 216576 x at IGK@ /// IGKC 27977 218692 at SYBU

HOXA9 /// MIR196B 25914 216623 x at TOX3 27985 218700 s at RAB7L1

23966 214669 x at IGKC 26125 216834 at RGS1 27996 21871 1 s at SDPR

24020 214723 x at ANKRD36 26132 216841_s_at LOC100129518 /// 28024 218739 at ABHD5

24065 214768 x at IGKC SOD2 28085 218800 at SRD5A3

24071 214774 x at TOX3 26196 216905 s at ST14 28090 218805_at GIMAP1 -GIMAP5 /

24074 214777 at 2621 1 216920 s at TARP /// TRGC2 GIMAP5

24100 214803 at CDH6 26236 216945 x at PASK 28161 218876 at TPPP3

24132 214836_x_at IGK@ /// IGKC /// 26275 216984_x_at CKAP2 /// IGLC1 /// 28170 218885 s at GALNT12

LOC100294406 IGLV1 -44 28186 218901 at PLSCR4

24212 214916_x_at IGHA1 /// IGHA2 /// 26398 217109 at MUC4 28234 218949 s at QRSL1

IGHG1 /// IGHG3 /// 26399 2171 10 s at MUC4 28245 218960 at TMPRSS4 IGHM /// IGHV3-23 26431 217143 s at YME1 L1 28251 218966 at MY05C

/// IGHV4-31 26436 217148 x at CKAP2 /// IGLC1 28275 218990 s at SPRR3

24241 214945_at FAM153A /// 26558 217272 s at SERPINB13 28280 218995 s at EDN1

FAM153B /// 26704 217418 x at MS4A1 28295 219010 at C1 orf106

FAM153C /// 26807 217521 at HAL 28376 219091 s at MMRN2

LOC 100507387 /// 26814 217528 at CLCA2 28400 2191 15 s at IL20RA

LOC100507427 26838 217552 x at CR1 28406 219121 s at ESRP1

24291 214995_s_at APOBEC3F /// 27024 217738 at NAMPT 28444 219159 s at SLAMF7

APOBEC3G

27025 217739 s at NAMPT 28446 219161_s_at CKLF /// CKL

24344 215049 x at CD163

27053 217767 at C3 CMTM1

24368 215073 s at NR2F2

27187 217901 at DSG2 28464 219179 at DACT1

24403 215108 x at TOX3

27252 217966 s at FAM129A 28467 219182 at TMEM231

24470 215175 at PCNX

27253 217967 s at FAM129A 28468 219183 s at CYTH4

24471 215176 x at LOC642838

27263 217977 at MSRB1 28589 219304 s at PDGFD

24518 215223_s_at LOC100129518 ///

27269 217983 s at RNASET2 28598 219313 at GRAMD1 C SOD2

27422 218136 s at SLC25A37 28653 219368 at NAP1 L2

24627 215332 s at CD8B

27472 218186 at RAB25 28668 219383 at PRR5L

24915 215621 s at IGHD

27558 218272 at TTC38 28708 219423 x at TNFRSF25

25023 215729 s at VGLL1

27605 218319 at PELI 1 28714 219429 at FA2H

25100 215806 x at TARP /// TRGC2

27639 218353 at RGS5 28719 219434 at TREM1

25219 215925 s at CD72

28721 219436 s at EMCN 29689 220404 at GPR97 31966 222686 s at CPPED1

28735 219450 at C4orf 19 29753 220468 at ARL14 31992 222712 s at MUC13

28737 219452 at DPEP2 29770 220485 s at SI RPG 31997 222717 at SDPR

28761 219476 at C1 orf1 16 29827 220542 s at BPIFA1 32030 222750 s at SRD5A3

28783 219498 s at BCL1 1 A 29931 220646 s at KLRF1 32053 222773 s at GALNT12

28793 219508 at GCNT3 30225 220940 at ANKRD36B 32083 222803 at PRTFDC1

28813 219528 s at BCL1 1 B 30275 220990 s at MIR21 /// VMP1 321 10 222830 at GRHL1

28814 219529 at CLIC3 30314 221029 s at WNT5B 321 13 222833 at LPCAT2

28865 219580 s at TMC5 30365 221081 s at DENND2D 321 18 222838 at SLAMF7

28879 219594 at NINJ2 30406 221 122 at HRASLS2 32165 222885 at EMCN

28915 219630 at PDZK1 IP1 30469 221 185 s at IQCG 32170 222890 at CCDC1 13

28951 219666 at MS4A6A 30494 221210 s at NPL 32171 222891 s at BCL1 1 A

28952 219667 s at BANK1 30523 221239 s at FCRL2 32175 222895 s at BCL1 1 B

28967 219682 s at TBX3 30537 221253_s_at MUTED-TXNDC5 /// 32184 222904 s at TMC5

28985 219700 at PLXDC1 TXNDC5 32195 222915 s at BANK1

29012 219727 at DUOX2 30629 221345 at FFAR2 32214 222934 s at CLEC4E

29053 219768 at VTCN1 30930 221648 s at AG MAT 32556 223278 at GJB2

29062 219777 at GIMAP6 30933 221651_x_at IGK@ /// IGKC /// 32560 223282 at TSHZ1

29080 219795 at SLC6A14 LOC100294406 32561 223283 s at TSHZ1

29084 219799 s at DHRS9 30953 221671_x_at IGK@ /// IGKC /// 32593 223315 at NTN4

29091 219806 s at C1 1 orf75 LOC100294406 32683 223405 at NPL

29097 219812 at PVRIG 30967 221685 s at CCDC99 32762 223484 at C15orf48

29135 219850 s at EHF 31037 221756 at PIK3IP1 32828 223551 at PKIB

29177 219892 at TM6SF1 31071 221790 s at LDLRAP1 32846 223569 at PPAPDC1 B

2921 1 219926 at POPDC3 31200 221919 at HNRNPA1 32897 223620 at GPR34

29221 219936 s at GPR87 31201 221920 s at SLC25A37 32908 223631 s at C19orf33

29223 219938 s at PSTPI P2 31227 221946 at C9orf1 16 32913 223636 at ZMYN D12

29244 219959 at MOCOS 31250 221969 at PAX5 3301 1 223734 at MGARP

29247 219962 at ACE2 31254 221973_at LOC 100506076 /// 33014 223737 x at CHST9

29270 219985 at HS3ST3A1 LOC100506123 33025 223748 at SLC4A1 1

29280 219995 s at ZNF750 31352 222071 s at SLC04C1 33052 223775 at HHIP

29299 220014 at PRR16 31354 222073 at COL4A3 33061 223784 at TMEM27

2931 1 220026 at CLCA4 31369 222088 s at SLC2A14 /// SLC2A3 33086 223809 at RGS18

29344 220059 at STAP1 31551 222271 at 331 13 223836 at FGFBP2

29353 220068 at VPREB3 31565 222285 at IGHD 33198 223922 x at MS4A6A

29373 220088 at C5AR1 31597 222317 at PDE3B 33228 223952 x at DHRS9

29446 220161 s at EPB41 L4B 31762 222482 at SSBP3 33284 224009 x at DHRS9

29458 220173 at C14orf45 31808 222528 s at SLC25A37 33462 224189 x at EHF

29462 220177 s at TMPRSS3 31809 222529 at SLC25A37 33481 224209 s at GDA

29615 220330 s at SAMSN1 31829 222549 at CLDN1 33589 224321 at TMEFF2

33595 224327 s at DGAT2 35278 226021 at RDH10 36161 226905 at FAM101 B

33623 224356 x at MS4A6A 35285 226028 at ROB04 36206 226950 at ACVRL1

33625 224358 s at MS4A7 35296 226039 at MGAT4A 36216 226960 at CXCL17

33641 224374 s at EMILIN2 35321 226064 s at DGAT2 36217 226961 at PRR15

33664 224400 s at CHST9 35322 226065 at PRICKLE1 36247 226991 at NFATC2

33670 224406 s at FCRL5 35324 226067 at BPI FB1 36288 227032 at PLXNA2

33676 224412 s at TRPM6 35326 226069 at PRICKLE1 36337 227081 at DNALI1

33698 224435 at FAM213A 35402 226145 s at FRAS1 36343 227087 at INPP4A

33725 224463 s at C1 1 orf70 35404 226147 s at PIGR 36375 2271 19 at CNOT6L

33910 224650 at MAL2 35407 226150 at PPAPDC1 B 36385 227129 x at FLJ45340

34043 224784 at MLLT6 35436 226179 at SLC25A37 36436 227180 at ELOVL7

34054 224795_x_at IGK@ /// IGKC /// 35442 226185 at CDS1 36452 227196 at RHPN2

LOC100294406 35446 226189 at ITGB8 36454 227198 at AFF3

34223 224964 s at GNG2 35470 226213 at ERBB3 36484 227228 s at CCDC88C

34339 225081 s at CDCA7L 35475 226218 at IL7R 36494 227238 at MUC15

34557 225299 at MY05B 35501 226244 at CLEC14A 36497 227241 at MUC15

34559 225301 s at MY05B 35529 226272 at RCAN3 36509 227253 at CP

34822 225564 at SPATA13 35532 226275 at MXD1 36517 227261 at KLF12

34855 225597 at SLC45A4 35604 226347 at FUT1 1 36545 227289 at PCDH17

34856 225598 at SLC45A4 35605 226348 at 36600 227344 at IKZF1

34884 225626 at PAG1 35631 226374 at CXADR 36609 227353 at TMC8

34903 225645 at EHF 35641 226384 at PPAPDC1 B 36610 227354 at PAG1

34925 225667 s at FAM84A 35681 226424 at CAPS 36615 227359 at OSCP1

34939 225681 at CTHRC1 35690 226433 at RNF157 36628 227372 s at BAIAP2L1

34986 225728 at SORBS2 35737 226480 at 36639 227383 at LOC727820

35025 225767 at RN45S 35792 226535 at ITGB6 36640 227384_s_at LOC727820 /

35075 225817 at CGNL1 35805 226548 at SBK1 LOC728855 /

35104 225846 at ESRP1 35817 226560 at LOC728875

35157 225899_x_at FLJ45340 /// 35878 226622 at MUC20 36706 227450 at ERP27

FLJ45445 /// 35881 226625 at TGFBR3 36717 227461 at STON2

LOC100128326 /// 35938 226682 at RORA 36731 227475 at FOXQ1

LOC 100289306 /// 36059 226803 at CHMP4C 36788 227533 at

LOC 100652945 ///

36100 226844 at MOB3B 36896 227641 at FBXL16

LOC100653241 ///

361 19 226863 at FAM1 10C 36901 227646 at EBF1

LOC 100653346 ///

36132 226876 at FAM101 B 36941 227686 at OXNAD1

LOC729737

36134 226878 at HLA-DOA 36960 227705 at TCEAL7

35232 225975 at PCDH18

36972 227717 at ARHGEF37 37903 228648 at LRG1 39285 230030 at HS6ST2

36980 227725 at ST6GALNAC1 37932 228677 s at RASAL3 39298 230043 at MUC20

37002 227747 at MPZL3 37948 228693 at CCDC50 39306 230051 at C10orf47

37010 227755 at 37962 228707 at CLDN23 39316 230061 at TM4SF18

37024 227769 at GPR27 38013 228758 at BCL6 39348 230093 at RSPH1

37034 227779 at 38017 228762 at LFNG 39390 230135 at HHIP

37035 227780 s at ECSCR 38021 228766 at CD36 39448 230193 at WDR66

37122 227867 at TRABD2A 38029 228774 at CEP78 39462 230207 s at DOCK5

37129 227874 at EMCN 38043 228788 at YPEL1 39500 230245 s at LOC283663

37132 227877 at ANXA2R 38082 228827 at RUNX1 T1 39505 230250 at PTPRB

37144 227889 at LPCAT2 38086 228831 s at GNG7 39518 230263 s at DOCK5

37178 227923 at SHANK3 38109 228854 at 39578 230323 s at TMEM45B

37221 227966_s_at CCDC74A /// 381 18 228863 at PCDH17 39588 230333 at

CCDC74B 38120 228865 at C1 orf1 16 39615 230360 at GLDN

37293 228038 at SOX2 38224 228969 at AGR2 39633 230378 at SCGB3A1

37322 228067 at C2orf55 38267 229012 at C9orf24 39719 230464 at S1 PR5

37349 228094 at AMICA1 38276 229021 at MCTP2 39754 230499 at BIRC3

37355 228100 at C1 orf88 38327 229072 at RAB30 39781 230526 at LOC100131096

37363 228108 at PPM1 L 38402 229147 at RASSF6 39805 230550 at MS4A6A

37398 228143 at CP 38483 229228_at CREB5 /// 39818 230563 at RASGEF1 A

37496 228241 at AGR3 LOC401317 39962 230707 at SORL1

37538 228283 at CMC1 38508 229253 at THEM4 39963 230708 at PRICKLE1

37553 228298 at PCED1 B 38509 229254 at MFSD4 39977 230722 at BNC2

37590 228335 at CLDN1 1 38582 229327 s at 39996 230741 at

37594 228339 at ECSCR 38622 229367 s at GIMAP6 40001 230746 s at

37602 228347 at SIX1 38632 229377 at GRTP1 40018 230763 at SPATA17

37627 228372 at C10orf128 38684 229429_x_at LOC728855 /// 40046 230791 at

37632 228377 at KLHL14 LOC728875 40225 230970 at

37636 228381 _at ATF7I P2 /// 38765 229510 at MS4A14 40332 231077 at C1 orf192

LOC100287628 38768 229513 at STRBP 40353 231098 at

37645 228390 at RAB30 38797 229542 at C20orf85 40379 231 124 x at LY9

37697 228442 at NFATC2 38821 229566 at LOC645638 40400 231 145 at PAX9

37705 228450 at PLEKHA7 38839 229584 at LRRK2 40421 231 166 at GPR155

37744 228489 at TM4SF18 38878 229623 at 40482 231227 at WNT5A

37773 228518 at IGHG1 /// IGHM 38903 229648 at ARHGAP32 40529 231274 s at

37783 228528 at 39042 229787 s at 40538 231283 at MGAT4A

37804 228549 at 39097 229842 at ELF3 40902 231647 s at FCRL5

37830 228575 at IL20RB 39165 229910 at SHE 40943 231688 at MMP8

37847 228592 at MS4A1 39189 229934 at 40983 231728 at CAPS

37854 228599 at MS4A1 39192 229937 x at 40984 231729 s at CAPS

41026 231771 at GJB6 44739 235489 at RHOJ 47970 238720 at LOC100506582

41031 231776 at EOMES 44817 235567 at RORA 48102 238852 at PRRX1

41092 231837 at USP28 44833 235583 at ILDR1 48155 238905 at RHOJ

41 196 231941 s at MUC20 44841 235591 at SSTR1 48255 239005 at

41282 232027 at SYNE1 44990 235740 at MCTP1 48400 239150 at SNTN

4131 1 232056 at SCEL 45001 235751 s at VM01 48481 239231 at

41337 232082 x at SPRR3 45013 235763 at SLC44A5 48537 239287 at

41406 232151 at MACC1 45048 235798 at TMEM170B 48542 239292 at

41419 232164 s at EPPK1 45169 235919 at CEP78 48692 239442 at CEP68

41459 232204 at EBF1 45174 235924 at 48848 239598 s at LPCAT2

41465 232210 at 45238 235988 at GPR1 10 48923 239673 at

41468 232213 at PELI1 45335 236085 at CAPSL 49058 239808 at

41489 232234 at SLA2 45476 236226 at BTLA 49166 239916 at WDR16

41559 232304 at PELI1 45512 236262 at MMRN2 49315 240065 at FAM81 B

41782 232527 at PSMD6-AS2 45545 236295 s at MIR3929 /// NLRC3 49320 240070 at TIGIT

41869 232614 at 45629 236379 at 4941 1 240161 s at CDC20B

41870 232615 at 45671 236421 at ANKRD45 49423 240173 at

41884 232629 at PROK2 45689 236439 at 49553 240303 at TMC5

41942 232687 at 45739 236489 at GPR1 10 49554 240304 s at TMC5

42136 232882 at 45789 236539 at PTPN22 49663 240413 at PYHIN1

42143 232889 at 45906 236656 s at LOC10028891 1 49716 240466 at

42752 233500 x at CLEC2D 46032 236782 at SAMD3 49749 240499 at

42942 233690 at 46157 236907 at 49822 240572 s at LOC374443

43557 234306 s at SLAMF7 46716 237466 s at HHI P 50080 240830 at SCARNA17

43582 234331 s at FAM84A 46875 237625 s at 501 1 1 240861 at

44014 234764_x_at CKAP2 /// IGLC1 /// 46987 237737 at LOC100289026 50448 241 198 s at C1 1 orf70

IGLV1 -44 47267 238017 at SDR16C5 50662 241412 at BTC

44220 234970 at TC2N 47313 238063 at TMEM154 50685 241435 at

44246 234996 at CALCRL 47353 238103 at LOC100505989 50931 241681 at

44325 235075 at DSG3 47366 2381 16 at DYNLRB2 51053 241803 s at

44391 235141 at MARVELD2 47371 238121 at GK5 51 135 241885 at

44394 235144 at RASEF 47679 238429 at TMEM71 51713 242463 x at ZNF600

44449 235199 at RNF125 47710 238460 at FAM83A 52059 242809 at IL1 RL1

44523 235273 at DYX1 C1 47728 238478 at BNC2 52121 242871 at PAQR5

44528 235278 at MACROD2 47774 238524 at 52157 242907 at GBP2

44622 235372 at FCRLA 47808 238558 at 52404 243154 at

44650 235400 at FCRLA 47834 238584 at IQCA1 52448 243198 at TEX9

44651 235401 s at FCRLA 47869 238619 at 52481 243231 at SLC38A1 1

44708 235458 at HAVCR2 47873 238623 at 52546 243296 at NAMPT

44726 235476 at TRIM59 47939 238689 at GPR1 10 52636 243386 at CASZ1

52663 243413 at TTC30B ANKRD20A2 /// 12516 203066 at CHST15

52694 243444 at SRD5A3 ANKRD20A3 /// 12573 203124 s at SLC1 1 A2

52742 243492 at THEM4 ANKRD20A4 /// 12753 203305 at F13A1

52860 243610 at C9orf135 ANKRD20A5P /// 12834 203386 at TBC1 D4

52979 243729 at ANKRD20A9P /// 12864 203416 at CD53

52995 243745 at LOC644339 12883 203435 s at MME

53030 243780 at 10051 200602 at APP 13098 203650 at PROCR

53259 244008 at PARP8 10055 200606 at DSP 13139 203691 at PI3

53423 244172 at 10097 200648 s at GLUL 13156 203708 at PDE4B

53564 244313 at CR1 10273 200824 at GSTP1 13189 203741 s at ADCY7

53665 244414 at 1031 1 200862 at DHCR24 13327 203879 at PIK3CD

54183 33322 i at SFN 10422 200973 s at TSPAN3 13371 203923 s at CYBB

54184 33323 r at SFN 10477 201028 s at CD99 13409 203961 at NEBL

54267 37145 at GNLY 10668 201219 at CTBP2 13421 203973 s at CEBPD

54309 38241 at BTN3A3 10710 201261 x at BGN 13505 204057 at IRF8

54326 39248 at AQP3 10727 201278 at DAB2 13514 204066 s at AGAP1

54327 39249 at AQP3 10738 201289 at CYR61 13551 204103 at CCL4

54329 39318 at TCL1 A 10750 201301 s at ANXA4 13560 2041 12 s at HNMT

54361 40560 at TBX2 10809 201360 at CST3 13649 204201 s at PTPN13

54514 57082 at LDLRAP1 10816 201367 s at ZFP36L2 13668 204220 at GMFG

54533 59437 at C9orf1 16 10871 201422 at I FI30 13713 204265 s at GPSM3

54557 64064_at GIMAP1 -GIMAP5 /// 1 1012 201563 at SORD 13721 204273 at EDNRB

GIMAP5 1 1094 201645 at TNC 13746 204298 s at LOX

54569 64900 at TMEM231 1 1291 201842 s at EFEMP1 13767 204319 s at RGS10

54598 823 at CX3CL1 1 1307 201858 s at SRGN 13776 204328 at TMC6

53 1552315 at GIMAP1 1 1308 201859 at SRGN 13807 204359_at FLRT2 /

55 1552318 at GIMAP1 1 1337 201888 s at IL13RA1 LOC100506718

260 1552623 at HSH2D 1 1388 201939 at PLK2 13894 204446 s at ALOX5

1473 1554306 at ITPKB 1 1448 201999 s at DYNLT1 13912 204464 s at EDNRA

2354 1555471 a at FMN2 1 1607 202158 s at CELF2 13941 204493 at BID

2391 1555526 a at SEPT6 1 1640 202191 s at GAS7 1401 1 204563 at SELL

2522 1555724 s at TAGLN 1 1641 202192 s at GAS7 14068 204620 s at VCAN

2572 1555786 s at LINC00520 1 1914 202465 at PCOLCE 14094 204646 at DPYD

3078 1556543 at 1 1930 202481 at DHRS3 14122 204674 at LRMP

3146 1556658 a at 12030 202581 at HSPA1 A /// HSPA1 B 14148 204700 x at DIEXF

3838 1557718 at PPP2R5C 12064 202615 at GNAQ 14161 204713 s at F5

4170 1558369 at MPHOSPH9 121 12 202663 at WIPF1 14162 204714 s at F5

4385 1558747 at SMCHD1 121 14 202665 s at WIPF1 14199 204751 x at DSC2

9325 1569607_s_at ANKRD20A1 /// 12282 202833 s at SERPINA1 14228 204780 s at FAS

ANKRD20A1 1 P /// 12407 202957 at HCLS1 14305 204857 at MAD1 L1

14308 204860_s_at LOC 100509323 /// 16603 207156_at HIST1H2AG /// 20167 210786 s at FLU

NAIP HIST1H2AH /// 20190 210809 s at POSTN

14330 204882 at ARHGAP25 HIST1H2AI /// 20196 210815 s at CALCRL

14339 204891 s at LCK HIST1H2AK /// 20272 210904 s at IL13RA1

14371 204923 at SASH3 HIST1H2AL /// 20310 210942 s at ST3GAL6

14372 204924 at TLR2 HIST1H2AM 20404 211038 s at CROCCP2

14407 204959 at MNDA 17085 207643 s at TNFRSF1 A 20450 211085 s at STK4

14419 204971 at CSTA 17116 207674 at FCAR 20465 211100 x at LILRA2

14453 205005 s at NMT2 17219 207777 s at SP140 20466 211101 x at LILRA2

14454 205006 s at NMT2 17297 207857 at LILRA2 20784 211454 x at FKSG49

14481 205033_s_at DEFA1 /// DEFA1B 17575 208146 s at CPVL 20907 211581 x at LST1

/// DEFA3 18106 208690 s at PDLIM1 20908 211582 x at LST1

14524 205076 s at MTMR11 18179 208763 s at TSC22D3 20938 211612 s at IL13RA1

14549 205101 at CIITA 18214 208798 x at GOLGA8A 20986 211661 x at PTAFR

14562 205114_s_at CCL3 /// CCL3L1 /// 18274 208858 s at ESYT1 21010 211688_x_at KIR3DL1 /

CCL3L3 18365 208949 s at LGALS3 KIR3DL2 /

14685 205237 at FCN1 18472 209057 x at CDC5L LOC727787

14814 205366 s at HOXB6 18498 209083 at COR01A 21046 211725 s at BID

14854 205406 s at SPA17 18554 209139 s at PRKRA 21053 211732 x at HNMT

14866 205418 at FES 18614 209199 s at MEF2C 21063 211742 s at EVI2B

14867 205419 at GPR183 18653 209238 at STX3 21069 211748 x at PTGDS

14873 205425 at HIP1 18677 209262 s at NR2F6 21111 211794 at FYB

15007 205559 s at PCSK5 18707 209292 at ID4 21228 211919 s at CXCR4

15075 205627 at CDA 18721 209306 s at SWAP70 21270 211962 s at ZFP36L1

15166 205718 at ITGB7 18762 209348 s at MAF 21281 211973 at

15252 205804 s at TRAF3IP3 18887 209473 at ENTPD1 21497 212190 at SERPINE2

15333 205885 s at ITGA4 18968 209555 s at CD36 21659 212353 at SULF1

15436 205988 at CD84 19017 209606 at CYTIP 21688 212382 at TCF4

15504 206057 x at SPN 19026 209615 s at PAK1 21866 212560 at SORL1

15507 206060 s at PTPN22 19105 209696 at FBP1 21908 212602 at WDFY3

15617 206170 at ADRB2 19340 209933 s at CD300A 21952 212646 at RFTN1

15661 206214 at PLA2G7 19544 210139 s at PMP22 21978 212672 at ATM

15724 206277 at P2RY2 19551 210146 x at LILRB2 21981 212675 s at CEP68

15784 206337 at CCR7 19683 210282 at ZMYM2 22077 212771 at FAM171A1

15879 206432 at HAS2 19822 210423 s at SLC11A1 22220 212915 at PDZRN3

15885 206438 x at TCTN2 19824 210425_x_at GOLGA8A /// 22309 213005 s at KANK1

16065 206618 at IL18R1 GOLGA8B /// 22336 213032 at NFIB

16071 206624 at USP9Y LOC100508892 22410 213106 at ATP8A1

16212 206765 at KCNJ2 19902 210511 s at INHBA 22446 213142 x at PION

16504 207057 at SLC16A7 20015 210629 x at LST1 22496 213193 x at TRBC1

20071 210686 x at SLC25A16

22606 213304 at FAM179B 25013 215719 x at FAS 28916 219631 at LRP12

2261 1 213309 at PLCL2 25207 215913 s at GULP1 29073 219788 at PILRA

22628 213326 at VAMP1 25260 215967 s at LY9 29106 219821 s at GFOD1

22826 213524 s at G0S2 25446 216153 x at RECK 291 18 219833 s at EFHC1

22906 213605 s at 25643 216351_x_at DAZ1 /// DAZ2 /// 29174 219889 at FRAT1

22967 213666 at SEPT6 DAZ3 /// DAZ4 29286 220001 at PADI4

23004 213703 at LINC00342 26198 216907_x_at KI R3DL1 /// 29290 220005 at P2RY13

23034 213733 at MY01 F KI R3DL2 /// 29319 220034 at IRAK3

23166 213865 at DCBLD2 LOC727787 29320 220035 at NUP210

23188 213888 s at TRAF3I P3 26272 216981 x at SPN 29351 220066 at NOD2

23205 213905 x at BGN 26319 217028 at CXCR4 29538 220253 s at LRP12

23247 213947 s at NUP210 26368 217078 s at CD300A 29862 220577 at GVINP1

23384 214084 x at NCF1 C 26435 217147 s at TRAT1 30239 220954 s at PILRB

23493 214193 s at DIEXF 26913 217627 at ZNF573 30342 221058 s at CKLF

23598 214298 x at SEPT6 27030 217744 s at PERP 30364 221080 s at DENND1 C

23666 214366 s at ALOX5 27124 217838 s at EVL 30491 221207 s at NBEA

23670 214370 at S100A8 27270 217984 at RNASET2 30518 221234 s at BACH2

23739 214439 x at BIN1 27278 217992 s at EFHD2 30533 221249 s at FAM1 17A

23767 214467 at GPR65 27435 218149 s at ZNF395 30864 221581 s at LAT2

23873 214574 x at LST1 27468 218182 s at CLDN1 30867 221584 s at KCNMA1

23974 214677 x at IGLC1 HIST2H2AA4 30946 221664 s at F1 1 R

24032 214735 at IPCEF1 27608 218322 s at ACSL5 30979 221698 s at CLEC7A

24050 214753 at N4BP2L2 27612 218326 s at LGR4 31259 221978 at HLA-F

24314 215019 x at ZNF528 27690 218404 at SNX10 31431 222150 s at PION

IGLV1 -44 28049 218764 at PRKCH 31546 222266 at

24418 215123_at 61 E3.4 /// 28087 218802 at CCDC109B 31609 222329 x at

LOC100132247 /// 28235 218950 at ARAP3 31672 222392 x at PERP

NPIPL3 28564 219279 at DOCK10 32082 222802 at EDN1

24441 215146 s at TTC28 28644 219359 at ATHL1 32157 222877 at

24530 215235 at SPTAN1 28697 219412 at RAB38 32324 223044 at SLC40A1

24564 215269 at TRAPPC10 28756 219471 at KIAA0226L 32558 223280 x at MS4A6A

24638 215343 at CCDC88C 28781 219496 at SOWAHC 32621 223343 at MS4A7

24674 215379 x at IGLV1 -44 28782 219497 s at BCL1 1 A 32622 223344 s at MS4A7

24741 215446 s at LOX 28790 219505 at CECR1 32753 223475 at CRISPLD1

24927 215633 x at LST1

32830 223553 s at DOK3 35283 226026 at DI RC2 37352 228097 at MYLI P

32895 223618 at FMN2 35293 226036 x at CASP2 37360 228105 at

32922 223645 s at TXLNG2P 35639 226382_at CAMK1 D /// 37376 228121 at TGFB2

33258 223983 s at C19orf12 LOC283070 37665 228410 at GAB3

33433 224159 x at TRIM4 35682 226425 at CLI P4 37747 228492 at USP9Y

33553 224284 x at FKSG49 35693 226436 at RASSF4 37767 228512 at PTCD3

33634 224367 at BEX2 35731 226474 at NLRC5 37840 228585 at ENTPD1

33713 224451 x at ARHGAP9 35782 226525 at STK17B 37868 228613 at RAB1 1 FIP3

33958 224698 at ESYT2 36027 226771 at ATP8B2 37895 228640 at PCDH7

33979 224719 s at C12orf57 36045 226789 at EMB 37963 228708 at RAB27B

34058 224799 at NDFIP2 36046 226790 at MORN2 38031 228776 at GJC1

34072 224813 at WASL 36074 226818 at MPEG1 38101 228846 at MXD1

34092 224833 at ETS1 36090 226834 at 38124 228869 at SNX20

34121 224862 at GNAQ 36135 226879 at HVCN1 38134 228879 at SNORD104

34168 224909 s at PREX1 36162 226906 s at ARHGAP9 38174 228919 at

34184 224925 at PREX1 36408 227152 at C12orf35 38219 228964 at PRDM1

34304 225046 at LOC389831 36430 227174 at WDR72 38325 229070 at ADTRP

34314 225056 at SIPA1 L2 36433 227177 at COR02A 38346 229091 s at CCNJ

34385 225127 at TMEM181 36438 227182 at SUSD3 38347 229092 at NR2F2

34395 225137 at NFATC3 36440 227184 at PTAFR 38396 229141 at SFT2D3 /// WDR33

34482 225224 at C20orf1 12 36444 227188 at FAM176C 38527 229272 at FNBP4

34520 225262 at FOSL2 36488 227232 at EVL 38586 229331 at SPATA18

34540 225282 at SMAP2 36635 227379 at MBOAT1 38759 229504 at

34566 225308 s at TANC1 36666 227410 at FAM43A 38778 229523 at

34579 225321 s at PILRB 36723 227467 at RDH10 38801 229546_at FAM84A /

34626 225368 at HIPK2 36862 227607 at STAMBPL1 LOC653602

34645 225387 at TSPAN5 36873 227618 at 38852 229597 s at WDFY4

34665 225407 at MBP 36900 227645 at PIK3R5 38978 229723 at TAGAP

34754 225496 s at SYTL2 36926 227671 at XIST 39086 229831 at CNTN3

34780 225522 at AAK1 36932 227677 at JAK3 39255 230000 at RNF213

34887 225629 s at ZBTB4 36995 227740 at UHMK1 39331 230076 at PITPNM3

34931 225673 at MYADM 37017 227762 at 39434 230179 at LOC285812

34946 225688 s at PHLDB2 37051 227796 at ZFP62 39507 230252 at LPAR5

34959 225701 at AKNA 37053 227798 at SMAD1 39519 230264 s at AP1 S2

34964 225706 at GLCCI1 37058 227803 at ENPP5 39525 230270 at PRPF38B

34989 225731 at ANKRD50 371 1 1 227856 at C4orf32 39547 230292 at

35122 225864 at FAM84B 37146 227891 s at TAF15 39627 230372 at HAS2

35141 225883 at ATG16L2 37155 227900 at CBLB 39646 230391 at CD84

35212 225955 at METRNL 37313 228058 at ZG16B 39749 230494 at SLC20A1

35279 226022 at SASH1 37326 228071 at GIMAP7 39924 230669 at RASA2

40091 230836 at ST8SIA4 47730 238480 at TTC39C 54408 44790 s at KIAA0226L

40121 230866 at CYSLTR1 47763 238513 at PRRG4 54559 64408 s at CALML4

40140 230885 at SPG7 47799 238549 at CBFA2T2 54588 74694 s at RABEP2

40180 230925 at APBB1 IP 47831 238581 at GBP5 probe number in the microarra

40457 231202 at ALDH1 L2 47899 238649 at PITPNC1

41002 231747 at CYSLTR1 47901 238651 at Affymetrix U133 Plus 2.0

41 103 231848 x at ZNF207 48096 238846 at TNFRSF1 1 A

4121 1 231956 at RNF213 48130 238880 at GTF3A ^** : Set.lD in the microarray Affymetri

41279 232024 at GIMAP2 48385 239135 at CPPED1 U133 Plus 2.0

41315 232060 at ROR1 48544 239294 at

41471 232216 at YME1 L1 48879 239629 at CFLAR

41744 232489 at TRMT13 48992 239742 at TULP4

41776 232521 at PCSK7 49143 239893 at

41798 232543 x at ARHGAP9 49196 239946 at

41799 232544 at 49209 239959 x at

41823 232568 at MGC24103 4931 1 240061 at

41873 232618 at TXLNG2P 49915 240665 at

41883 232628 at 50286 241036 at

42097 232843 s at DOCK8 50882 241632 x at

43198 233947 s at TBX5-AS1 50972 241722 x at

44296 235046 at INPP4B 51 155 241905 at PIK3C2A

44388 235138 at 51371 242121 at

44415 235165 at PARD6B 51475 242225 at

44421 235171 at LOC100505501 51489 242239 at

44463 235213 at ITPKB 51518 242268 at CELF2

44492 235242 at 51641 242391 at

44671 235421 at MAP3K8 51697 242447 at C3orf70

44818 235568 at C19orf59 51789 242539 at DIS3L2

44843 235593 at ZEB2 521 12 242862 x at

44920 235670 at STX1 1 52266 243016 at

44948 235698 at ZFP90 52606 243356 at

45061 23581 1 at 52715 243465 at

45129 235879 at 52851 243601 at LOC285957

45329 236079 at LOC202025 53849 244598 at LCP2

45774 236524 at 53928 244677 at

45804 236554 x at TMC8 54234 35974 at LRMP

4581 1 236561 at TGFBR1 54306 38149 at ARHGAP25

46259 237009 at 5431 1 38290 at RGS14

47003 237753 at IL21 R 54332 39549 at NPAS2

47591 238341 at — 54380 41469 at PI3

Table 5: Alternative list of analyzed genes Probe* Set.lD** Gene.Symbol Probe* Set.lD** Gene.Symbol

2371 1555497 a at CYP4B1 8966 1568964 x at SPN

Probe* Set.lD** Gene. Symbol 2450 1555613 a at ZAP70 9163 1569344 a at

3 1 17 at HSPA6 2467 1555638 a at SAMSN1 9349 1569652 at MLLT3

9 1405 i at CCL5 2501 1555691_a_at KLRC4-KLRK1 /// 10400 200951 s at CCND2

62 1552326 a at CCDC1 1 KLRK1 10402 200953 s at CCND2

83 1552365 at SCIN 2529 1555731 a at AP1 S3 10491 201042 at TGM2

84 1552367 a at SCIN 2549 1555756 a at CLEC7A 10507 201058 s at MYL9

91 1552378 s at RDH10 2552 1555759 a at CCL5 10567 201 1 18 at PGD

155 1552477 a at I RF6 2565 1555778 a at POSTN 10580 201 131 s at CDH1

174 1552502 s at RHBDL2 2566 1555779 a at CD79A 10596 201 147 s at TIMP3

209 1552553 a at NLRC4 2723 1555997 s at IGFBP5 10598 201 149 s at TIMP3

231 1552584 at IL12RB1 2727 1556003 a at LOC100506777 10599 201 150 s at TIMP3

238 1552594 at TMEM190 2746 1556037 s at HHIP 10691 201242 s at ATP1 B1

270 1552634 a at ZNF101 2840 1556185 a at STEAP4 10735 201286 at SDC1

364 1552767 a at HS6ST2 2857 1556209 at CLEC2B 10736 201287 s at SDC1

387 1552797 s at PROM2 2916 1556300 s at SIM1 10836 201387 s at UCHL1

394 1552806 a at SIGLEC10 3053 1556499 s at COL1 A1 10887 201438 at COL6A3

395 1552807 a at SIGLEC10 3109 1556601 a at SPATA13 10959 201510 at ELF3

606 1553105 s at DSG2 3145 1556657 at 1 1027 201578 at PODXL

616 15531 18 at THEM4 3427 1557080 s at ITGBL1 1 1099 201650 at KRT19

660 1553177 at SH2D1 B 3779 1557636 a at C7orf57 1 1 104 201655 s at HSPG2

748 1553297 a at CSF3R 4054 15581 1 1 at MBNL1 1 1 193 201744 s at LUM

841 1553423 a at SLFN13 4108 1558217 at SLFN13 1 1234 201785 at RNASE1

977 1553589 a at PDZK1 I P1 4334 1558662 s at BANK1 1 1269 201820 at KRT5

989 1553605 a at ABCA13 4522 1558971 at THEMIS 1 1288 201839 s at EPCAM

994 1553613 s at FOXC1 4523 1558972 s at THEMIS 1 1292 201843 s at EFEMP1

1039 1553681 a at PRF1 4587 1559078 at 1 1302 201853 s at CDC25B

1081 1553734 at AK7 4728 1559333 at SRGAP3-AS2 1 1333 201884 at CEACAM5

1249 1553986 at RASEF 4758 1559391 s at 1 1342 201893 x at DCN

1353 1554140 at WDR78 4778 1559425 at 1 1412 201963 at ACSL1

1425 1554240 a at ITGAL 4876 1559584 a at C16orf54 1 1454 202005 at ST14

1432 1554250 s at TRIM73 5325 1560396 at KLHL6 1 1467 202018 s at LTF

1502 1554343 a at STAP1 5326 1560397 s at KLHL6 1 1532 202083 s at SEC14L1

1546 1554406 a at CLEC7A 6651 1562529 s at 1 1561 2021 12 at VWF

1681 1554588 a at TTC30B 7017 1563075 s at 1 1655 202206 at ARL4C

1745 1554676 at SRGN 7029 1563088 a at LOC284837 1 1656 202207 at ARL4C

KGFLP2 8086 1565913 at 1 1690 202241 at TRIB1

21 13 1555167 s at NAMPT 8251 1566342 at 1 1759 202310 s at COL1 A1

2150 1555214 a at CLEC7A 8716 1567913 at 1 1760 20231 1 s at COL1 A1

2263 1555355 a at ETS1

Probe* Set.lD** Gene. Symbol Probe* Set.lD** Gene.Symbol Probe* Set.lD** Gene.Symbol

1 1790 202341 s at TRIM2 12673 203224 at RFK 13622 204174 at ALOX5AP

1 1791 202342 s at TRIM2 12704 203256 at CDH3 13640 204192 at CD37

1 1806 202357 s at CFB 12738 203290 at HLA-DQA1 13645 204197 s at RUNX3

1 1837 202388 at RGS2 12835 203387 s at TBC1 D4 13646 204198 s at RUNX3

1 1840 202391 at BASP1 12845 203397 s at GALNT3 13716 204268 at S100A2

1 1852 202403 s at COL1 A2 12855 203407 at PPL 13752 204304 s at PROM1

1 1903 202454 s at ERBB3 LOC 100653255 /// 13837 204389 at MAOA

1 1938 202489 s at FXYD3 NELL2 13841 204393 s at ACPP

1 1946 202497 x at SLC2A3 12872 203424 s at IGFBP5 13903 204455_at DST /

1 1947 202498 s at SLC2A3 12901 203453 at SCNN1 A LOC100652766

1 1948 202499 s at SLC2A3 12933 203485 at RTN1 13914 204466 s at SNCA

1 1953 202504 at TRIM29 12957 203509 at SORL1 13916 204468 s at TI E1

1 1973 202524 s at SPOCK2 13009 203561 at FCGR2A 13917 204469 at PTPRZ1

1 1974 202525 at PRSS8 13022 203574 at NFIL3 13920 204472 at GEM

12074 202625 at LYN 13039 203591 s at CSF3R 14000 204552 at INPP4A

12075 202626 s at LYN 13093 203645 s at CD163 14029 204581 at CD22

12190 202741 at PRKACB 13154 203706 s at FZD7 14036 204588 s at SLC7A7

12191 202742 s at PRKACB 13174 203726 s at LAMA3 14043 204595 s at STC1

12197 202748 at GBP2 13195 203747 at AQP3 14044 204596 s at STC1

12239 202790 at CLDN7 13205 203757 s at CEACAM6 14045 204597 x at STC1

12275 202826 at SPINT1 13213 203765 at GCA 14101 204653 at TFAP2A

12280 202831 at GPX2 13272 203824 at TSPAN8 14103 204655 at CCL5

12339 202890 at MAP7 13276 203828 s at IL32 141 15 204667 at FOXA1

12360 202910 s at CD97 13337 203889 at SCG5 14125 204677 at CDH5

12397 202947 s at GYPC 13340 203892 at WFDC2 14127 204679 at KCNK1

12421 202971 s at DYRK2 13358 203910 at ARHGAP29 14129 204681 s at RAPGEF5

12438 202988 s at RGS1 13365 203917 at CXADR 14131 204683 at ICAM2

12440 202990 at PYGL 13369 203921 at CHST2 14179 204731 at TGFBR3

12471 203021 at SLPI 13382 203934 at KDR 14182 204734 at KRT15

12495 203045 at NINJ1 13384 203936 s at MMP9 14198 204750 s at DSC2

12524 203074_at ANXA8 /// 13401 203953 s at CLDN3 14225 204777 s at MAL

12533 203083 at THBS2 FCGR3B 14250 204802 at RRAD

12572 203123 s at SLC1 1 A2 13455 204007 at FCGR3B 14251 204803 s at RRAD

12575 203126 at IMPA2 13520 204072 s at FRY 14259 20481 1 s at CACNA2D2

12580 203131 at PDGFRA 13564 2041 16 at IL2RG 14269 204821 at BTN3A3

12589 203140 at BCL6 13608 204160 s at ENPP4 14294 204846 at CP

12629 203180 at ALDH1 A3 13609 204161 s at ENPP4 14303 204855 at SERPINB5

14338 204890 s at LCK 14976 205528 s at RUNX1 T1 15506 206059 at ZNF91

14380 204932 at TNFRSF1 1 B 14980 205532 s at CDH6 15546 206099 at PRKCH

14381 204933 s at TNFRSF1 1 B 14992 205544 s at CR2 15558 2061 1 1 at RNASE2

14397 204949 at ICAM3 14995 205547 s at TAGLN 15565 2061 18 at STAT4

14409 204961_s_at NCF1 /// NCF1 B /// 15016 205568 at AQP9 15567 206120 at CD33

NCF1 C 15038 205590 at RASGRP1 15597 206150 at CD27

14462 205014 at FGFBP1 15043 205595 at DSG3 15604 206157 at PTX3

14489 205041 s at ORM1 /// ORM2 15045 205597 at SLC44A4 1561 1 206164 at CLCA2

14492 205044 at GABRP 15060 205612 at MMRN1 15612 206165 s at CLCA2

14497 205049 s at CD79A 15071 205623 at ALDH3A1 15613 206166 s at CLCA2

14512 205064 at SPRR1 B 151 19 205671 s at HLA-DOB 15618 206171 at ADORA3

14516 205068 s at ARHGAP26 15129 205681 at BCL2A1 15619 206172 at IL13RA2

14567 2051 19 s at FPR1 15157 205709 s at CDS1 15644 206197 at NME5

14595 205147 x at NCF4 15173 205725 at SCGB1 A1 15653 206206 at CD180

14605 205157 s at JUP /// KRT17 15206 205758 at CD8A 15654 206207 at CLC

14607 205159 at CSF2RB 15213 205765 at CYP3A5 15669 206222 at TNFRSF10C

14619 205171 at PTPN4 15216 205768 s at SLC27A2 15691 206244 at CR1

14622 205174 s at QPCT 15217 205769 at SLC27A2 15723 206276 at LY6D

14628 205180 s at ADAM8 15228 205780 at BIK 15771 206324 s at DAPK2

14633 205185 at SPINK5 15238 205790 at SKAP1 15778 206331 at CALCRL

14634 205186 at DNALI 1 15246 205798 at IL7R 15810 206363 at MAF

14638 205190 at PLS1 15269 205821_at KLRC4-KLRK1 /// 15813 206366 x at XCL1

14661 205213 at ACAP1 KLRK1 15824 206377 at FOXF2

14662 205214 at STK17B 15276 205828 at MMP3 15845 206398 s at CD19

14668 205220 at HCAR3 15279 205831 at CD2 15847 206400_at LGALS7 /

14715 205267 at POU2AF1 15294 205846 at PTPRB LGALS7B

14739 205291 at IL2RB 15331 205883 at ZBTB16 1591 1 206464 at BMX

14745 205297 s at CD79B 15336 205888 s at JAKMI P2 15925 206478 at KIAA0125

14767 205319 at PSCA 15338 205890 s at GABBR1 /// UBD 15928 206481 s at LDB2

14776 205328 at CLDN10 15346 205898 at CX3CR1 15962 206515 at CYP4F3

14851 205403 at IL1 R2 15347 205899 at CCNA1 15969 206522 at MGAM

14870 205422 s at ITGBL1 15349 205901 at PNOC 15992 206545 at CD28

14882 205434 s at AAK1 15364 205916 at S100A7 16008 206561 s at AKR1 B10

14904 205456 at CD3E 15370 205922 at VNN2 16031 206584 at LY96

14918 205470 s at KLK1 1 15372 205924 at RAB3B 16042 206595 at CST6

14924 205476 at CCL20 15427 205979 at SCGB2A1 16078 206631 at PTGER2

14936 205488 at GZMA 15438 205990 s at WNT5A 16084 206637 at P2RY14

14943 205495 s at GNLY 15476 206028 s at MERTK 16090 206643 at HAL

14949 205501 at PDE10A 15480 206032 at DSC3 161 13 206666 at GZMK

14961 205513 at TCN1 15481 206033 s at DSC3 16123 206676 at CEACAM8

16130 206683 at ZNF165 17869 208450 at LGALS2 19129 209720 s at SERPINB3

16154 206707 x at FAM65B 17907 208488 s at CR1 19200 209791 at PADI2

16208 206761 at CD96 17958 208539 x at SPRR2B 19201 209792 s at KLK10

16251 206804 at CD3G SAA2-SAA4 19222 209815 at PTCH1

16331 206884 s at SCEL 18195 208779 x at DDR1 /// MIR4640 19248 209841 s at LRRN3

16361 206914 at CRTAM 18431 209016 s at KRT7 19270 209863 s at TP63

16371 206924 at IL1 1 18485 209070 s at RGS5 19271 209864 at FRAT2

16425 206978 at CCR2 18486 209071 s at RGS5 19278 209871 s at APBA2

16430 206983 at CCR6 18502 209087 x at MCAM 19288 209881 s at LAT

16455 207008 at CXCR2 18529 2091 14 at TSPAN1 19301 209894 at LEPR

16465 207018 s at RAB27B 18535 209120 at NR2F2 19312 209905_at HOXA10-HOXA9 /

16519 207072 at IL18RAP 18536 209121 x at NR2F2 HOXA9

16523 207076 s at ASS1 18540 209125 at KRT6A 19332 209925 at OCLN

16541 207094 at CXCR1 18541 209126 x at KRT6B 19337 209930 s at NFE2

16558 2071 1 1 at EMR1 18553 209138 x at IGLC1 19353 209946 at VEGFC

16624 207178 s at FRK 18588 209173 at AGR2 19362 209955 s at FAP

16721 207275 s at ACSL1 18594 209179 s at MBOAT7 19400 209993 at ABCB1

16737 207291 at PRRG4 18599 209184 s at IRS2 19402 209995 s at TCL1 A

16758 207313_x_at KI R3DL1 /// 18600 209185 s at IRS2 19432 210026 s at CARD10

KI R3DL2 /// 18615 209200 at MEF2C 19437 210031 at CD247

LOC727787 18626 20921 1 at KLF5 19444 210038 at PRKCQ

16773 207328 at ALOX15 18627 209212 s at KLF5 19445 210039 s at PRKCQ

16795 207351 s at SH2D2A 18704 209289 at NFIB 19470 210064 s at UPK1 B

16873 207430 s at MSMB 18705 209290 s at NFIB 19471 210065 s at UPK1 B

16912 207469 s at PI R 18749 209335 at DCN 19501 210096 at CYP4B1

16952 207509 s at LAI R2 18765 209351 at KRT14 19510 210105 s at FYN

17052 207610 s at EMR2 18782 209368 at EPHX2 19522 2101 17 at SPAG1

17093 207651 at GPR171 18788 209374 s at IGHM 19524 2101 19 at KCNJ15

17097 207655 s at BLNK 18809 209395 at CHI3L1 19545 210140 at CST7

171 19 207677 s at NCF4 18810 209396 s at CHI3L1 19569 210164 at GZMB

17165 207723 s at KLRC3 18820 209406 at BAG2 19581 210176 at TLR1

17237 207795 s at KLRD1 18943 209529 at PPAP2C 19589 210184 at ITGAX

17244 207802 at CRISP3 18953 209539 at ARHGEF6 19624 210222 s at RTN1

17259 207819 s at ABCB4 18993 209582 s at CD200 19645 210244 at CAMP

17287 207847 s at MUC1 19080 209670 at TRAC 19698 210297 s at MSMB

17372 207935 s at KRT13 19081 209671 x at TRAC 19721 210321 at GZMH

1741 1 207979 s at CD8B 19095 209686 at S100B 19747 210347 s at BCL1 1 A

17693 208268 at ADAM28 19128 209719 x at SERPINB3 19755 210356 x at MS4A1

19796 210397_at DEFB1 20962 21 1637_x_at IGH@ /// IGHA1 /// 22333 213029 at NFIB

19812 210413_x_at SERPINB3 /// IGHA2 /// IGHD /// 22398 213094 at GPR126

SERPINB4 IGHG1 /// IGHG3 /// 22413 213109 at TNIK

19821 210422 x at SLC1 1 A1 IGHG4 /// IGHM /// 22475 213172 at TTC9

19825 210426 x at RORA IGHV3-23 /// 22543 213240 s at KRT4

19847 210448 s at P2RX5 IGHV4-31 22544 213241 at PLXNC1

19881 210484_s_at LOC254896 /// 20970 21 1645 x at 22587 213285 at TMEM30B

TNFRSF10C 20982 21 1657 at CEACAM6 22640 213338 at TMEM158

19897 210505 at ADH7 21007 21 1685 s at NCALD 22694 213392 at IQCK

19992 210606 x at KLRD1 21009 21 1687 x at KIR3DL1 22720 213418 at HSPA6

20098 210715 s at SPINT2 21055 21 1734 s at FCER1 A 22727 213425 at WNT5A

20136 210754 s at LYN 21 130 21 1813 x at DCN 22836 213534 s at PASK

20154 210772 at FPR2 21205 21 1896 s at DCN 22843 213541 s at ERG

20155 210773 s at FPR2 2121 1 21 1902 x at YME1 L1 22912 21361 1 at AQP5

20208 210827 s at ELF3 21215 21 1906 s at SERPINB4 22921 213620 s at ICAM2

20228 210847 x at TNFRSF25 21231 21 1922 s at CAT 22975 213674 x at IGHD

20270 210895 s at CD86 21267 21 1959 at IGFBP5 22980 213679 at TTC30A

TRAV20 21543 212236 x at JUP /// KRT17 22994 213693 s at MUC1

20360 210992 x at FCGR2C 21546 212239 at PIK3R1 23038 213737 x at GOLGA8IP

20373 21 1005 at LAT 21547 212240 s at PIK3R1 23097 213796 at SPRR1 A

20526 21 1 163 s at TNFRSF10C 21617 21231 1 at SEL1 L3 23131 213830 at YME1 L1

20554 21 1 192 s at CD84 21638 212332 at RBL2 23150 213849 s at PPP2R2B

20625 21 1272 s at DGKA 21660 212354 at SULF1 23206 213906 at MYBL1

20646 21 1302 s at PDE4B 21666 212360 at AMPD2 23208 213908_at WHAMMP2 /

20678 21 1339 s at ITK 21792 212486 s at FYN WHAMMP3

20679 21 1340 s at MCAM 21807 212501 at CEBPB 23215 213915 at NKG7

20698 21 1361 s at SERPINB13 21837 212531 at LCN2 23229 213929 at EXPH5

20709 21 1372 s at IL1 R2 21905 212599 at AUTS2 23254 213954 at FAM169A

20731 21 1395 x at FCGR2C 21944 212638 s at WWP1 23332 214032 at ZAP70

20845 21 1518 s at BMP4 22126 212820 at DMXL2 23349 214049 x at CD7

20859 21 1532_x_at KI R2DS1 /// 22133 212827 at IGHM 23361 214061 at WDR67

KI R2DS2 /// 22135 212829 at PIP4K2A 23370 214070 s at ATP10B

KI R2DS3 /// 22149 212843 at NCAM1 23371 214071 at GNAL

KI R2DS4 /// 22214 212909 at LYPD1 23483 214183 s at TKTL1

KI R2DS5 /// 22246 212942 s at KIAA1 199 23540 214240 at GAL

KIR3DL3 22279 212975 at DENND3 23738 214438 at HLX

20923 21 1597 s at HOPX

23750 214450 at CTSW 25219 215925 s at CD72 27605 218319 at PELI1

23756 214456 x at SAA1 /// SAA2 25239 215945 s at TRIM2 27639 218353 at RGS5

23770 214470 at KLRB1 25283 215990 s at BCL6 27754 218468 s at GREM1

23849 214549 x at SPRR1 A 25326 216033 s at FYN 27755 218469 at GREM1

23867 214567 s at XCL1 /// XCL2 25484 216191 s at TRDV3 27787 218501 at ARHGEF3

23879 214580_x_at KRT6A /// KRT6B /// 25500 216207_x_at IGKC /// 27796 218510 x at FAM134B

KRT6C LOC642838 27818 218532 s at FAM134B

23881 214582 at PDE3B 25545 216252 x at FAS 27900 218614 at C12orf35

23916 214617 at PRF1 25693 216401 x at 27962 218677 at S100A14

23950 214651_s_at HOXA10-HOXA9 /// 25783 216491 x at IGHM 27972 218687 s at MUC13

HOXA9 /// MI R196B 25867 216576 x at IGK@ /// IGKC 27977 218692 at SYBU

23966 214669 x at IGKC 25914 216623 x at TOX3 27985 218700 s at RAB7L1

24020 214723 x at ANKRD36 26125 216834 at RGS1 27996 21871 1 s at SDPR

24065 214768 x at IGKC 26132 216841_s_at LOC100129518 /// 28024 218739 at ABHD5

24071 214774 x at TOX3 SOD2 28085 218800 at SRD5A3

24074 214777 at 26196 216905 s at ST14 28090 218805_at GIMAP1 -GIMAP5 /

24100 214803 at CDH6 2621 1 216920 s at TARP /// TRGC2 GIMAP5

LOC100294406 26275 216984_x_at CKAP2 /// IGLC1 /// 28170 218885 s at GALNT12

24212 214916_x_at IGHA1 /// IGHA2 /// IGLV1 -44 28186 218901 at PLSCR4

IGHG1 /// IGHG3 /// 26398 217109 at MUC4 28234 218949 s at QRSL1

IGHM /// IGHV3-23 26399 2171 10 s at MUC4 28245 218960 at TMPRSS4 /// IGHV4-31 26431 217143 s at YME1 L1 28251 218966 at MY05C

FAM153B /// 26558 217272 s at SERPINB13 28280 218995 s at EDN1

FAM153C /// 26704 217418 x at MS4A1 28295 219010 at C1 orf106 LOC 100507387 /// 26807 217521 at HAL 28376 219091 s at MMRN2

LOC100507427 26814 217528 at CLCA2 28400 2191 15 s at IL20RA

24291 214995_s_at APOBEC3F /// 26838 217552 x at CR1 28406 219121 s at ESRP1

APOBEC3G 27024 217738 at NAMPT 28444 219159 s at SLAMF7

24344 215049 x at CD163 27025 217739 s at NAMPT 28446 219161_s_at CKLF /// CKL

24368 215073 s at NR2F2 27053 217767 at C3 CMTM1

24403 215108 x at TOX3 27187 217901 at DSG2 28464 219179 at DACT1

24470 215175 at PCNX 27252 217966 s at FAM129A 28467 219182 at TMEM231

24471 215176 x at LOC642838 27253 217967 s at FAM129A 28468 219183 s at CYTH4

24518 215223_s_at LOC100129518 /// 27263 217977 at MSRB1 28589 219304 s at PDGFD

SOD2

27269 217983 s at RNASET2 28598 219313 at GRAMD1 C

24627 215332 s at CD8B

27422 218136 s at SLC25A37 28653 219368 at NAP1 L2

24915 215621 s at IGHD

27472 218186 at RAB25 28668 219383 at PRR5L

25023 215729 s at VGLL1

27558 218272 at TTC38 28708 219423 x at TNFRSF25

25100 215806 x at TARP /// TRGC2

28714 219429 at FA2H 29462 220177 s at TMPRSS3 31808 222528 s at SLC25A37

28719 219434 at TREM1 29615 220330 s at SAMSN1 31809 222529 at SLC25A37

28721 2 9436 s at EMCN 29689 220404 at GPR97 31829 222549 at CLDN1

28735 219450 at C4orf19 29753 220468 at ARL14 31966 222686 s at CPPED1

28737 219452 at DPEP2 29770 220485 s at SIRPG 31992 222712 s at MUC13

28761 219476 at C1 orf1 16 29827 220542 s at BPIFA1 31997 222717 at SDPR

28783 219498 s at BCL1 1 A 29931 220646 s at KLRF1 32030 222750 s at SRD5A3

28793 219508 at GCNT3 30225 220940 at ANKRD36B 32053 222773 s at GALNT12

28813 219528 s at BCL1 1 B 30275 220990 s at MI R21 /// VMP1 32083 222803 at PRTFDC1

28814 219529 at CLIC3 30314 221029 s at WNT5B 321 10 222830 at GRHL1

28865 219580 s at TMC5 30365 221081 s at DENND2D 321 13 222833 at LPCAT2

28879 219594 at NINJ2 30406 221 122 at HRASLS2 321 18 222838 at SLAMF7

28915 219630 at PDZK1 I P1 30469 221 185 s at IQCG 32165 222885 at EMCN

28951 219666 at MS4A6A 30494 221210 s at NPL 32170 222890 at CCDC1 13

28952 219667 s at BANK1 30523 221239 s at FCRL2 32171 222891 s at BCL1 1 A

28967 219682 s at TBX3 30537 221253_s_at MUTED-TXNDC5 /// 32175 222895 s at BCL1 1 B

28985 219700 at PLXDC1 TXNDC5 32184 222904 s at TMC5

29012 219727 at DUOX2 30629 221345 at FFAR2 32195 222915 s at BANK1

29053 219768 at VTCN1 30930 221648 s at AGMAT 32214 222934 s at CLEC4E

29062 219777 at GIMAP6 30933 221651_x_at IGK@ /// IGKC /// 32556 223278 at GJB2

29080 219795 at SLC6A14 LOC100294406 32560 223282 at TSHZ1

29091 219806 s at C1 1 orf75 LOC100294406 32593 223315 at NTN4

29097 219812 at PVRIG 30967 221685 s at CCDC99 32683 223405 at NPL

29135 219850 s at EHF 31037 221756 at PIK3I P1 32762 223484 at C15orf48

29177 219892 at TM6SF1 31071 221790 s at LDLRAP1 32828 223551 at PKIB

2921 1 219926 at POPDC3 31200 221919 at HNRNPA1 32846 223569 at PPAPDC1 B

29221 219936 s at GPR87 31201 221920 s at SLC25A37 32897 223620 at GPR34

29223 219938 s at PSTPIP2 31227 221946 at C9orf1 16 32908 223631 s at C19orf33

29244 219959 at MOCOS 31250 221969 at PAX5 32913 223636 at ZMYN D12

29247 219962 at ACE2 31254 221973_at LOC 100506076 /// 3301 1 223734 at MGARP

29270 219985 at HS3ST3A1 LOC100506123 33014 223737 x at CHST9

29280 219995 s at ZNF750 31352 222071 s at SLC04C1 33025 223748 at SLC4A1 1

29299 220014 at PRR16 31354 222073 at COL4A3 33052 223775 at HHIP

2931 1 220026 at CLCA4 31369 222088_s_at SLC2A14 /// 33061 223784 at TMEM27

29344 220059 at STAP1 SLC2A3 33086 223809 at RGS18

29353 220068 at VPREB3 31551 222271 at 331 13 223836 at FGFBP2

29373 220088 at C5AR1 31565 222285 at IGHD 33198 223922 x at MS4A6A

29446 220161 s at EPB41 L4B 31597 222317 at PDE3B 33228 223952 x at DHRS9

29458 220173 at C14orf45 31762 222482 at SSBP3 33284 224009 x at DHRS9

33462 224189 x at EHF LOC 100653346 /// 361 19 226863 at FAM1 10C

33481 224209 s at GDA LOC729737 36132 226876 at FAM101 B

33589 224321 at TMEFF2 35232 225975 at PCDH18 36134 226878 at HLA-DOA

33595 224327 s at DGAT2 35278 226021 at RDH10 36161 226905 at FAM101 B

33623 224356 x at MS4A6A 35285 226028 at ROB04 36206 226950 at ACVRL1

33625 224358 s at MS4A7 35296 226039 at MGAT4A 36216 226960 at CXCL17

33641 224374 s at EMILIN2 35321 226064 s at DGAT2 36217 226961 at PRR15

33664 224400 s at CHST9 35322 226065 at PRICKLE1 36247 226991 at NFATC2

33670 224406 s at FCRL5 35324 226067 at BPIFB1 36288 227032 at PLXNA2

33676 224412 s at TRPM6 35326 226069 at PRICKLE1 36337 227081 at DNALI1

33698 224435 at FAM213A 35402 226145 s at FRAS1 36343 227087 at INPP4A

33725 224463 s at C1 1 orf70 35404 226147 s at PIGR 36375 2271 19 at CNOT6L

33910 224650 at MAL2 35407 226150 at PPAPDC1 B 36385 227129 x at FLJ45340

34043 224784 at MLLT6 35436 226179 at SLC25A37 36436 227180 at ELOVL7

34054 224795_ _x_at IGK@ /// IGKC /// 35442 226185 at CDS1 36452 227196 at RHPN2

LOC100294406 35446 226189 at ITGB8 36454 227198 at AFF3

34223 224964 s at GNG2 35470 226213 at ERBB3 36484 227228 s at CCDC88C

34339 225081 s at CDCA7L 35475 226218 at IL7R 36494 227238 at MUC15

34557 225299 at MY05B 35501 226244 at CLEC14A 36497 227241 at MUC15

34559 225301 s at MY05B 35529 226272 at RCAN3 36509 227253 at CP

34822 225564 at SPATA13 35532 226275 at MXD1 36517 227261 at KLF12

34855 225597 at SLC45A4 35604 226347 at FUT1 1 36545 227289 at PCDH17

34856 225598 at SLC45A4 35605 226348 at 36600 227344 at IKZF1

34884 225626 at PAG1 35631 226374 at CXADR 36609 227353 at TMC8

34903 225645 at EHF 35641 226384 at PPAPDC1 B 36610 227354 at PAG1

34925 225667 s at FAM84A 35681 226424 at CAPS 36615 227359 at OSCP1

34939 225681 at CTHRC1 35690 226433 at RNF157 36628 227372 s at BAIAP2L1

34986 225728 at SORBS2 35737 226480 at 36639 227383 at LOC727820

35025 225767 at RN45S 35792 226535 at ITGB6 36640 227384_s_at LOC727820 /

35075 225817 at CGNL1 35805 226548 at SBK1 LOC728855 /

35104 225846 at ESRP1 35817 226560 at LOC728875

35157 225899_ _x_at FLJ45340 /// 35878 226622 at MUC20 36706 227450 at ERP27

FLJ45445 /// 35881 226625 at TGFBR3 36717 227461 at STON2

LOC100128326 /// 35938 226682 at RORA 36731 227475 at FOXQ1

LOC100132050 /// 35951 226695 at PRRX1 36748 227492_at LOC647859 /

LOC100287894 /// 36033 226777 at ADAM12 OCLN

LOC100289306 /// 36059 226803 at CHMP4C 36788 227533 at

LOC100506479 /// 36073 226817 at DSC2 36821 227566_at LOC100653217 /

LOC100508632 /// 36097 226841 at MPEG1 NTM

LOC100652945 /// 36100 226844 at MOB3B 36896 227641 at FBXL16

LOC100653241 ///

36901 227646 at EBF1 37830 228575 at IL20RB 39165 229910 at SHE

36941 227686 at OXNAD1 37847 228592 at MS4A1 39189 229934 at

36960 227705 at TCEAL7 37854 228599 at MS4A1 39192 229937 x at

36972 227717 at ARHGEF37 37903 228648 at LRG1 39285 230030 at HS6ST2

36980 227725 at ST6GALNAC1 37932 228677 s at RASAL3 39298 230043 at MUC20

37002 227747 at MPZL3 37948 228693 at CCDC50 39306 230051 at C10orf47

37010 227755 at 37962 228707 at CLDN23 39316 230061 at TM4SF18

37024 227769 at GPR27 38013 228758 at BCL6 39348 230093 at RSPH1

37034 227779 at 38017 228762 at LFNG 39390 230135 at HHIP

37035 227780 s at ECSCR 38021 228766 at CD36 39448 230193 at WDR66

37122 227867 at TRABD2A 38029 228774 at CEP78 39462 230207 s at DOCK5

37129 227874 at EMCN 38043 228788 at YPEL1 39500 230245 s at LOC283663

37132 227877 at ANXA2R 38082 228827 at RUNX1 T1 39505 230250 at PTPRB

37144 227889 at LPCAT2 38086 228831 s at GNG7 39518 230263 s at DOCK5

37178 227923 at SHANK3 38109 228854 at 39578 230323 s at TMEM45B

37221 227966_s_at CCDC74A /// 381 18 228863 at PCDH17 39588 230333 at

CCDC74B 38120 228865 at C1 orf1 16 39615 230360 at GLDN

37293 228038 at SOX2 38224 228969 at AGR2 39633 230378 at SCGB3A1

37322 228067 at C2orf55 38267 229012 at C9orf24 39719 230464 at S1 PR5

37349 228094 at AMICA1 38276 229021 at MCTP2 39754 230499 at BIRC3

37355 228100 at C1 orf88 38327 229072 at RAB30 39781 230526 at LOC100131096

37363 228108 at PPM1 L 38402 229147 at RASSF6 39805 230550 at MS4A6A

37398 228143 at CP 38483 229228_at CREB5 /// 39818 230563 at RASGEF1 A

37496 228241 at AGR3 LOC401317 39962 230707 at SORL1

37538 228283 at CMC1 38508 229253 at THEM4 39963 230708 at PRICKLE1

37553 228298 at PCED1 B 38509 229254 at MFSD4 39977 230722 at BNC2

37590 228335 at CLDN1 1 38582 229327 s at 39996 230741 at

37594 228339 at ECSCR 38622 229367 s at GIMAP6 40001 230746 s at

37602 228347 at SIX1 38632 229377 at GRTP1 40018 230763 at SPATA17

37627 228372 at C10orf128 38684 229429_x_at LOC728855 /// 40046 230791 at

37632 228377 at KLHL14 LOC728875 40225 230970 at

37636 228381_at ATF7IP2 /// 38765 229510 at MS4A14 40332 231077 at C1 orf192

LOC100287628 38768 229513 at STRBP 40353 231098 at

37645 228390 at RAB30 38797 229542 at C20orf85 40379 231 124 x at LY9

37697 228442 at NFATC2 38821 229566 at LOC645638 40400 231 145 at PAX9

37705 228450 at PLEKHA7 38839 229584 at LRRK2 40421 231 166 at GPR155

37744 228489 at TM4SF18 38878 229623 at 40482 231227 at WNT5A

37773 228518 at IGHG1 /// IGHM 38903 229648 at ARHGAP32 40529 231274 s at

37783 228528 at 39042 229787 s at 40538 231283 at MGAT4A

37804 228549 at 39097 229842 at ELF3 40902 231647 s at FCRL5

40943 231688 at MMP8 44651 235401 s at FCRLA 47869 238619 at

40983 231728 at CAPS 44708 235458 at HAVCR2 47873 238623 at

40984 231729 s at CAPS 44726 235476 at TRIM59 47939 238689 at GPR1 10

41026 231771 at GJB6 44739 235489 at RHOJ 47970 238720 at LOC100506582

41031 231776 at EOMES 44817 235567 at RORA 48102 238852 at PRRX1

41092 231837 at USP28 44833 235583 at ILDR1 48155 238905 at RHOJ

41 196 231941 s at MUC20 44841 235591 at SSTR1 48255 239005 at

41282 232027 at SYNE1 44990 235740 at MCTP1 48400 239150 at SNTN

4131 1 232056 at SCEL 45001 235751 s at VM01 48481 239231 at

41337 232082 x at SPRR3 45013 235763 at SLC44A5 48537 239287 at

41406 232151 at MACC1 45048 235798 at TMEM170B 48542 239292 at

41419 232164 s at EPPK1 45169 235919 at CEP78 48692 239442 at CEP68

41459 232204 at EBF1 45174 235924 at 48848 239598 s at LPCAT2

41465 232210 at 45238 235988 at GPR1 10 48923 239673 at

41468 232213 at PELI 1 45335 236085 at CAPSL 49058 239808 at

41489 232234 at SLA2 45476 236226 at BTLA 49166 239916 at WDR16

41559 232304 at PELI 1 45512 236262 at MMRN2 49315 240065 at FAM81 B

41782 232527 at PSMD6-AS2 45545 236295 s at MI R3929 /// NLRC3 49320 240070 at TIGIT

41869 232614 at 45629 236379 at 4941 1 240161 s at CDC20B

41870 232615 at 45671 236421 at ANKRD45 49423 240173 at

41884 232629 at PROK2 45689 236439 at 49553 240303 at TMC5

41942 232687 at 45739 236489 at GPR1 10 49554 240304 s at TMC5

42136 232882 at 45789 236539 at PTPN22 49663 240413 at PYHIN1

42143 232889 at 45906 236656 s at LOC10028891 1 49716 240466 at

42752 233500 x at CLEC2D 46032 236782 at SAMD3 49749 240499 at

42942 233690 at 46157 236907 at 49822 240572 s at LOC374443

43557 234306 s at SLAMF7 46716 237466 s at HHIP 50080 240830 at SCARNA17

43582 234331 s at FAM84A 46875 237625 s at 501 1 1 240861 at

IGLV1 -44 47267 238017 at SDR16C5 50662 241412 at BTC

44220 234970 at TC2N 47313 238063 at TMEM154 50685 241435 at

44246 234996 at CALCRL 47353 238103 at LOC100505989 50931 241681 at

44325 235075 at DSG3 47366 2381 16 at DYNLRB2 51053 241803 s at

44391 235141 at MARVELD2 47371 238121 at GK5 51 135 241885 at

44394 235144 at RASEF 47679 238429 at TMEM71 51713 242463 x at ZNF600

44449 235199 at RNF125 47710 238460 at FAM83A 52059 242809 at IL1 RL1

44523 235273 at DYX1 C1 47728 238478 at BNC2 52121 242871 at PAQR5

44528 235278 at MACROD2 47774 238524 at 52157 242907 at GBP2

44622 235372 at FCRLA 47808 238558 at 52404 243154 at

44650 235400 at FCRLA 47834 238584 at IQCA1 52448 243198 at TEX9

probe number in the microarray

Affymetrix U133 Plus 2.0

^** : Set.lD in the microarray Affymetrix

U133 Plus 2.0

In a preferred embodiment, said step C) of the methods of the invention is implemented by a computer.

Method for determining prognosis of a patient suffering from cancer In the context of the invention, the term "prognosis" refers to the future evolution of a particular cancer relative to the patient suffering of this particular cancer.

Said prognosis may be global survival prognosis or survival without relapse prognosis.

By "global survival prognosis" is meant prognosis of survival, with or without relapse. As well-known from the skilled person, in the case of lung cancer, the survival time, with or without relapse, depends on the stage of the disease. Typically, in stage I of lung cancer, the mean global survival is of 50% after 5 years. Typically, in stage II of lung cancer, the mean global survival is of 50% after 42 months. Typically, in stage III of lung cancer, the mean global survival is of 50% after 24 months. Typically, in stage IV of lung cancer, the mean global survival is of 50% after 6 months. Accordingly, a poor or good prognosis of survival will depend on the cancer stage. Typically, a poor survival time prognosis is defined as the occurrence of death within 6 months, 24 months, 42 months or 5 years, preferably within 42 months or 5 years, most preferably within 5 years, whereas a good survival time prognosis is defined as the lack of death during the following 6 months, 24 months, 42 months or 5 years, preferably during the following 42 months or 5 years, most preferably during the following 5 years.

By "survival without relapse prognosis" is meant prognosis of survival in the absence of any relapse. As well-known from the skilled person, in the case of lung cancer, the survival time, with or without relapse, depends on the stage of the disease. Typically, in stage I of lung cancer, the mean survival without relapse is of 50% after 5 years. Typically, in stage II of lung cancer, the mean survival without relapse is of 50% after 42 months. Typically, in stage III of lung cancer, the mean survival without relapse is of 50% after 24 months. Typically, in stage IV of lung cancer, the mean survival without relapse is of 50% after 6 months. Accordingly, a poor or good prognosis of survival will depend on the cancer stage. Typically, a poor survival without relapse prognosis is defined as the presence of tumor-relapse within 6 months, 24 months, 42 months or 5 years, preferably within 42 months or 5 years, most preferably within 5 years, whereas a good survival without relapse prognosis is defined as the lack of relapse during following 6 months, 24 months, 42 months or 5 years, preferably during the following 42 months or 5 years, most preferably during the following 5 years. The inventors demonstrated for example that the coefficient associated with the vessels subpopulation enabled distinguishing patients with a high risk of relapse from patients who do not relapse. In particular, a coefficient associated with the vessels subpopulation superior to 0.1099 is associated with a good prognosis.

In a particular embodiment, the method for determining prognosis of a patient suffering from cancer of the invention further comprises a step C) of determining at least one ratio between at least two coefficients estimated in step C), and wherein step D) is carried out on the basis of said at least one ratio determined in step C).

Indeed, the inventors demonstrated that the ratio between coefficients associated with specific subpopulations provided a still more accurate prognosis than coefficients considered individually.

In a particular embodiment, at least one of the following ratio is determined at step

C') _' β⁶Ρ'"^ηΘ''^&' / pfibroblasts pepilhelial j pvessels pepilhelial j pCD14 pepilhelial j pCD19 pepilhelial j pCD56 pepilhelial j pCD8 pepilhelial j peosinophils pepilhelial j pneutrophils pfibroblasts j pepilhelial pfibroblasts j pvessels pfibroblasts j pCD14 pfibroblasts j pCD19 pfibroblasts j pCD56 pfibroblasts j pCD8 pfibroblasts j peosinophils pfibroblasts J pneutrophils pvessels j pepilhelial pvessels j pfibroblasts pvessels j pCD14 pvessels j pCD19 pvessels j βΟϋ56 pvessels j pCD8 pvessels j peosinophils pvessels j pneulrophils pCD14 j pepithelial pCD14 j pfibroblasts βΟϋ14 J pvessels βΟϋ14 j βΟϋ19 βΟϋ14 j pCD56 βΟϋ14 j pCD8 βΟϋ14 j peosinophils βΟϋ14 j pneutrophils βΟϋ19 J pepithelial βΟϋ19 j pfibroblasts βΟϋ19 j pvessels βΟϋ19 j βΟϋ14 βΟϋ19 j pCD56 βΟϋ19 j pCD8 βΟϋ19 j peosinophils βΟϋ19 j pneutrophils pCD56 j pepithelial pCD56 j pfibroblasts pCD56 j pvessels pCD56 j pCD14 pCD56

I βΟϋ19 βΟϋ56 I βθϋδ βΟϋ56 j peosinophils pCD56 j pneutrophils pCD8 j pepithelial pCD8 j pfibroblasts pCD8 j pvessels pCD8 j pCD14 pCD8 j pCD19 pCD8 j pCD56 pCD8 j peosinophils pCD8 j pneutrophils peosinophils j pepithelial peosinophils j pfibroblasts peosinophils j pvessels peosinophils j pCD14 peosinophils j pCD19 peosinophils j pCD56 peosinophils j pCD8 peosinophils j pneutrophils pneutrophils j pepithelial pneutrophils j pfibroblasts pneutrophils j pvessels pneutrophils j pCD14 pneutrophils j pCD19 pneutrophils j pCD56 pneutrophils j pCD8 _Q_, pneutrophils j peosinophils |_{n a} p_ar†j_cu|_ar|y preferable embodiment, at least one of the following ratio is determined at Step C) : 3^neutr°P^{hi ls} / β⁰⁰¹⁴, β^Π«ΛίορΗΙ₈ / pCD pneutrophils / pneutrophils / pCD8 _{Q r}

pneutrophils j peosinophils

In some embodiments, the coefficients associated with a combination of subpopulations may be determined. For example, the coefficient associated with a combination of the subpopulations CD8 and CD56 and/or the coefficient associated with a combination of the subpopulations eosinophils and neutrophils may be determined. Method for stratifying patients

An object of the invention concerns a method for stratifying patients suffering from cancer based on the transcriptomic pattern of cell subpopulations from their tumor stromal environment.

In this method of the invention, the patients are stratified on the basis of the coefficients estimated in step C), as defined in the section "Step C)" above.

Method for selecting a patient for an anticancerous therapy Another object of the invention concerns a method for selecting a patient suffering from cancer for an anticancerous therapy targeting a specific cell subpopulation from tumor stromal environment.

By "anticancerous therapy targeting a specific cell subpopulation from tumor stromal environment" is meant herein an anticancerous treatment targeting one of cell subpopulations defined in the section "Definitions" above.

Such anticancerous therapies are well-known from the skilled person. For example, antiangiogenic therapies target the vessels subpopulation while anti-PD1 or anti- CTLA4 immunotherapies target the immune cells subpopulation.

In a particular embodiment of the method of selection of the invention, the patient is selected for an anticancerous therapy targeting the cell subpopulation, the estimated coefficient of which has been determined as the highest in step C), as defined in the section "Step C)" above.

Method for determining the response to an anticancerous therapy Another object of the invention concerns a method for determining the response of a patient suffering from cancer to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment.

The expression "anticancerous therapy targeting a specific cell subpopulation from tumor stromal environment" has the same meaning as the one defined in the section "Method for selecting a patient for an anticancerous therapy" above.

In this method of the invention, the response of the patient to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment is determined on the basis of the coefficients estimated in step C) as defined in the section "Step C) above". The present invention will be further illustrated by the figures and examples below. Brief description of the figures

Figure 1 : Box plots of expressions of the 54675 genes of each subject of the cohort GSE10245 described in Example 1 .

Figure 2: Box plots of expressions of the 54675 genes of each subject of the cohort GSE10245 described in Example 1 after the withdrawal of the 4 subjects identified in Figure 1 and before RMA normalization. Figure 3: Box plots of expressions of the 54675 genes of each subject of the cohort GSE10245 described in Example 1 after the withdrawal of the 4 subjects identified in Figure 1 and after RMA normalization.

Figure 4: Box plots of expressions of the 54675 genes of each subject of the subpopulation epithelial defined by the cohort GSE48466 described in Example 1 .

Figure 5: Box plots of expressions of the 54675 genes of each subject of the subpopulation fibroblasts defined by the cohort GSE44723 described in Example 1 . Figure 6: Box plots of expressions of the 54675 genes of each subject of the subpopulation vessels defined by the cohort GSE48786 described in Example 1 .

Figure 7: Box plots of expressions of the 54675 genes of each subject of the subpopulation immune cells defined by the cohort GSE28490 described in Example 1 .

Figure 8: Box plots of the cohorts GSE44723, GSE48466, GSE48786 and GSE28490 before normalization inter-cohort.

Figure 9: Box plots of the cohorts GSE44723, GSE48466, GSE48786 and GSE28490 after normalization inter-cohort.

Figure 10: Graphic representation of the variance of housekeeping genes (black dots) and of the variance of the most variable genes (grey dots) inside the subpopulations after applying the kmeans++ procedure. Figure 11 : Number of genes identified to establish the statistical modellings ("final genes") which are not housekeeping genes, control (AFFX) genes, sexual genes and do not constitute background noise. Figure 12: Box plots of the ratios (6.10), (6.1 1 ), (6.12), (6.13), (6.14) and (6.15) defined in Example 1 , calculated with n_A observations.

Figure 13: Box plots of the ratios (6.10), (6.1 1 ), (6.12), (6.13), (6.14) and (6.15) defined in Example 1 , calculated with n_T observations.

Figure 14: Box plots of coefficients calculated using the least squares procedure and associated with each subpopulation to reconstitute the global gene signature of 54 patients suffering from lung cancer. Figure 15: Box plots of coefficients calculated using the ridge + BGH procedure and associated with each subpopulation to reconstitute the global gene signature of 54 patients suffering from lung cancer.

Figure 16: Box plots of coefficients calculated using the ridge + 10-fold cross-validation procedure and associated with each subpopulation to reconstitute the global gene signature of 54 patients suffering from lung cancer.

Figure 17: Box plots of coefficients calculated using the PLS1 procedure and associated with each subpopulation to reconstitute the global gene signature of 54 patients suffering from lung cancer.

Figure 18: Decision tree designed based on the coefficients estimated in Example 2. In the decision tree, the branches a, c, e, g, i, k, m, o, q, s and u correspond to a positive response to the corresponding knot, whereas the branches b, d, f, h, j, I, n, p, r, t and v correspond to a negative response to the corresponding knot.

Figure 19: Overall survival curve obtained on patients suffering from lung cancer of stage 1 or 2 in Example 2, according to the coefficient associated with the vessels subpopulation. Figure 20: Disease free survival curve obtained on patients suffering from lung cancer of stage 1 or 2 in Example 2, according to the coefficient associated with the vessels subpopulation.

Examples Example 1

This example presents the method used by the inventors to model the global transcriptional expression level pattern Y of genes according to the transcriptional expression level pattern X® of said genes in 9 cell subpopulations from the tumor stromal environment.

In this example, the inventors modeled the influence of biological entities on a heterogeneous complex. From real data, they decomposed the gene signature obtained in patients suffering from lung cancer into gene signatures of entities which constitute the associated tumoral stroma.

The inventors considered gene expressions from biologically heterogeneous tissue and cell types from the lung tumoral stroma, which, in variable proportions, would contribute to the gene expression of a global signature of non-small cell lung cancer. Identifying these different proportions is a major economical and scientific goal since it is an in silico alternative to laboratory separation techniques to understand cancer expansion.

The present example describes a modeling method, based on partial deconvolution from known gene expressions.

1. Methodology to identify gene expressions

After a presentation of raw databases considered in the present example, pre- treatments applied to these data to constitute the database used as starting point for modeling gene expression of patients suffering from lung cancer are detailed.

1. 1. Databases used

The inventors used a set of samples, the data of which are stocked in publicly available files in the public database Gene Expression Omnibus (GEO). The files considered gather the fluorescence intensities measures quantifying the expression level of each gene. The measure of the expression level of genes is possible by the use of DNA microarrays (of the type HG-U133_plus_2 (Affymetrix Human Genome U133 Plus 2.0 Array).

Each of the following databases, herein called cohort, gathers the signature of 54,675 genes obtained from several subjects.

GSE48466 gathers the gene expressions measured in bronchial epithelial cells from 12 subjects suffering from lung cancer. This cohort defines the explanatory variable epithelial.

GSE44723 gathers the gene expressions measured in fibroblasts of 14 subjects suffering from lung fibrosis. This cohort defines the explanatory variable fibroblasts.

GSE48786 gathers the gene expressions measured from endothelial cells from breast cancer in 6 subjects. This cohort defines the explanatory variable vessels.

GSE28490 gathers the gene expressions measured in immune cells of 47 subjects.

Since blood concentrates different cell populations which have different functions and are associated with distinct gene expressions, the inventors did not consider only one variable but several, each being representative of one of the following cell populations:

• CD14 cells (monocytes) analyzed in 10 subjects;

· CD19 cells (B lymphocytes) analyzed in 5 subjects;

• CD4 cells analyzed in 5 subjects;

• CD56 cells (NK cells) analyzed in 5 subjects;

• CD8 cells analyzed in 5 subjects;

• Eosinophils analyzed in 4 subjects;

· Neutrophils analyzed in 3 subjects;

• Plasmacytoid dendritic cells (pDC) analyzed in 5 subjects,

• Myeloid dendritic cells (mDC) analyzed in 5 subjects.

As used herein, the term subpopulation refers to cohorts GSE48466, GSE44723,

GSE48786 and to cell populations of GSE28490.

GSE10245 gathers global gene expressions of 58 patients suffering from NSCLC

(adenocarcinoma and squamous cell carcinoma): 40 subjects presented the histological subtype adenocarcinoma and 18 subjects presented the histological subtype squamous cell carcinoma. This cohort defines the variables to be explained. 1.2. Pretreatments applied to databases

Two types of pretreatments were applied: homogenization of the cohorts and selection of genes. The inventors first established a homogenization between subjects of the cohort GSE10245 and a homogenization inter- and intra- subpopulations. Then, they identified non-expressed genes inside the cohort GSE10245 and genes which did not discriminate subpopulations.

1.2.1. Homogenization of gene expressions in the cohort GSE10245

The inventors first analyzed gene patterns, at the logarithmic scale base 2, of each subject of the cohort GSE10245 through box plot representation, as shown in Figure 1 .

About 75% of gene expressions of 4 specific subjects were inferior to 6. In other words, compared to other subjects of the cohort and globally, genes of these 4 subjects were not expressed. The inventors thus decide to withdraw these subjects from the study. Concerning the other subjects of this cohort, the inventors noticed some variations between gene patterns of different subjects. The origin of these differences between subjects can be explained in two ways. These differences can be purely biological differences due to the fact that each individual possess a personal gene pattern. Alternatively, artefacts can feed variations between the patterns. Actually, these two points cumulate since the observed patterns associated a pure biological signal and artefacts linked to the experiment. To only observe the pure signature, the inventors used automated procedures of so called normalization. In the present case, they used the RMA (Robust Multichip Averaging) method, as defined above. It was used by the function justRMA of the software R, available in the package affy, obtainable on the Bioconductor website.

The RMA procedure induced changes in the gene signatures of the subjects of the cohort GSE10245. As can be seen by comparing Figures 2 and 3, variations present between subjects were drastically reduced, thereby underlined the presence of artefacts in the initial gene signatures. Now, certain homogeneity can be observed between the gene expressions of the different subjects.

1.2.2. Homogenization of gene expressions of subpopulations.

The inventors applied the same treatments of subpopulations, namely:

1 ) identification of non-expressed subjects inside each subpopulation,

2) homogenization of every subpopulation by the RMA normalization procedure They realized a first analysis of the initial gene signatures, at the logarithmic scale base 2, of each subject of the cohorts GSE48466, GSE44723, GSE48786 and GSE28490, by the box plots representations of figures 4 to 7.

Analysis of the box plots of Figures 4 to 7 shows that the subjects of each of the cohorts GSE48466 (Figure 4), GSE44723 (Figure 5) and GSE48786 (Figure 6) display a similar gene pattern. Gene patterns of the cohort GSE28490 (Figure 7) are more variable between each other. In particular, the genes of 10 subjects possess about 75% of the genes inferior to 6 (after base 2 logarithm transformation). As above, the inventors qualified these subjects as non-expressed and withdrew them from the study. Since the subpopulations mDC and pDC were represented by the subjects withdrawn from the study, these subpopulations were withdrawn.

In order to emphasize biological variations between subpopulations, the inventors further used the RMA procedure. They studied changes on the gene signatures of the subjects of the different subpopulations and showed that the variations present between the subjects of the different subpopulations were greatly reduced through the RMA procedure, as shown by the alignment of the medians and extreme values between 2 and 14 (in logarithmic scale base 2), which can be observed on Figures 8 and 9.

The CD4 subpopulation has the particularity to share most of its markers with other cell subpopulations of the cohort GSE28490. In the initial list of genes, very few are specific of this subpopulation and the observed CD4 gene signature is here only a doubloon of the CD8 signature among others. The CD4 subpopulation was thus withdrawn from the study.

1.3. Selection of genes: withdrawal of control genes, sexual genes, background noise genes and housekeeping genes

The inventors identified two types of genes: those which are not expressed and those whose expression does not enable differentiating subpopulations. To identify these 2 subsets, the inventors first resume for each subpopulation the gene expressions measured in the different subjects. For this, they calculated, inside each subpopulation, the median value of each gene and gathered all these results in a "median subject" representative of each of the 9 subpopulations. It was thus possible to illustrate the links existing between the subpopulations by correlations between the median subjects, which are presented in Table 5 below. Table 5: Correlations between median subjects of subpopulations on 54 765 genes without base 2 logarithmic transformation

In Table 5, strong correlations can be observed between different populations. However, similarly to artefacts above, which induce noise on the pure biological signal, the two sets of genes which are looked for feed these correlations and do not reflect real biological links.

Among the 54 675 initial genes, the inventors first withdrew so called control genes, which can be identified by the prefix "AFFX-" and sexual genes (XIST, RPS4Y1 , DDX3Y, TXLNG2P, USP9Y, EIF1 AY, KDM5D) which do not bring any relevant information for the modelling of the global gene signature of patients suffering from lung cancer.

Secondly, the inventors identified the two types of genes mentioned above:

• Inside the GSE10245 cohort, they looked for the genes the expression of which is inferior to a particular threshold whoever the considered subject.

This subset gathers non-expressed genes feeding the background noise;

• Inside the subpopulations represented by the median subjects, they looked for genes the expression of which does not enable differentiating these biological subtypes. This subset gathers the housekeeping genes which are, by definition, genes mostly encoding proteins which are essential to cell viability. They are present in most cells with a signature almost identical whoever the subject and/or the changes in the biological environment.

The methods used to identify these subsets of genes are described below. Identification of genes feeding the background noise

To identify the first subset of genes, the inventors graphically analyzed the gene signature of each subject of the cohort GSE10245 and defined as non-expressed the genes the maximal gene expression of which, on the whole set of subjects of this cohort, is inferior to about 6.75 (in logarithmic scale base 2). This threshold is the median of the maximal values of each gene, calculated on the 54 subjects of the cohort GSE10245. It is a threshold that can be considered as acceptable, for this cohort, to identify non- expressed genes, since, previously, subjects with a majority (i.e. about 75%) of gene expressions inferior to 6 were considered as non-expressed. These operations enable withdrawing genes of low intensity in the cohort GSE10245 and in the subpopulations, which keeping reference genes such as CD8A. There is thus 27 296 genes left which are neither control genes or sexual genes, nor do they feed the background noise.

Identification of housekeeping genes

The identification of the second subset of genes, once the background noise genes are withdrawn, corresponds to distinguishing the most variable genes from the least variable genes between the median subjects representative of the subpopulations.

To achieve this goal, the inventors calculated, for each gene, the variance on the 9 median subjects, and used the kmeans++ method (available in the R package), as defined above, to identify two groups: the group of non-discriminating genes, i.e. with low variance, and the group of genes discriminating subpopulations.

The genes associated with a variance comprised between 0.003 and 3.579, as depicted on Figure 10, are housekeeping genes. They represent about 91 % of the 27296 analyzed genes. The remaining 9% of genes, associated with a variance comprised between 3.581 and 22.556, as depicted on Figure 10, are the genes finally kept for modeling. The different genes withdrawn from the study are resumed on Figure 1 1 .

As shown on Figure 1 1 , about 50% of the 54675 initial genes were withdrawn from the study since, according to the criteria applied by the inventors, they fed the background noise or were identified as control or sexual. About 45% of the initial genes were identified, according to the present methodology, as housekeeping genes. Finally, after the different "filters" applied by the inventors on the normalized data, 4.37% of the initial genes, corresponding to 2389 genes, were kept.

Every genes withdrawn from the study did feed the correlations between the subpopulations, as testified by the correlation between fibroblasts and CD14 which was of 0.77 before the selection of genes, and which is now of 0.16 in Table 6 below. Table 6 : Correlations between median subjects of subpopulations on 2389 genes with base 2 logarithmic transformation

2. Modellings of gene signature of lung cancer

The statistical strategy adopted to identify the influence of the above subpopulations of global gene expression of patients suffering from lung cancer is described herein.

The inventors compared the estimation performances of different methods, namely the least squares method, the ridge method (with the BGH procedure or the 10-fold cross- validation) and the PLS1 and analyzed the results in light of biological reality.

2. 1. Protocol

To integrate this study to a wider project including 6 further cohorts of patients suffering from lung cancer, the inventors used 2250 genes for the following modellings. This limitation does not disturb the associations observed above in Table 6 between the subpopulations, as testified by the following Table 7 of correlations below.

Table 7 : Correlations between median subjects of subpopulations on 2250 genes with base 2 logarithmic transformation

Fibro Epithelial Vessels CD14 CD19 CD56 CD8 Eosino Neutro

Fibro 1 .00 0.20 0.63 0.15 0.13 0.1 1 0.22 -0.05 -0.09

Epithelial 0.20 1 .00 0.25 0.19 0.10 0.05 0.15 0.04 0.04

Vessels 0.63 0.25 1 .00 0.14 0.10 0.1 1 0.18 0.01 -0.05

CD14 0.15 0.19 0.14 1 .00 0.47 0.35 0.50 0.48 0.54

CD19 0.13 0.10 0.10 0.47 1 .00 0.39 0.58 0.27 0.12

CD56 0.1 1 0.05 0.1 1 0.35 0.39 1 .00 0.75 0.33 0.19 CD8 0.22 0.15 0.18 0.50 0.58 0.75 1 .00 0.33 0.20

Eosino -0.05 0.04 0.01 0.48 0.27 0.33 0.33 1 .00 0.66

Neutro -0.09 0.04 -0.05 0.54 0.12 0.19 0.20 0.66 1 .00

To test the modeling performances of different statistical procedure, the inventors considered a first set of data (x„ V;)_{i=1 Π}Α randomly gathering 60% of n=2250 initial observations. Here is noted Y^e) the vector having as coordinates the n_A gene expression of the subject e of the cohort GSE10245 and ^Y(t) its estimation according to the following multiple regression model:

9

(6.1 )

where the Xfⁱ⁾ e R^nA, for j = 1 ,...,9 gather the n_A gene expressions of the 9 median subjects representing the subpopulations, which are presented in Table 8 below.

Table 8: Correspondence between the explanatory variables of the multiple regression model given by equation (6.1 ) and the biological subpopulations.

The least squares method, the ridge method (with BGH or 10-fold cross- validation), and PLS1 were applied on standard data. In the models obtained with each method, the inventors introduced a constant because it is possible that a stationary gene expression exists in the global gene expression of cancer. By a return on the original data, it is obtained, for each method, an estimation of Y^e) for e = 1 ,...,54 defined by the following equations (6.2), (6.3), (6.4), (6.5) :

9

-¾.me + ^ ^"

³⁼¹ (6.2) 8

YBGH = βθ,Β^βΗ +∑ J,BGHX^W

³⁼¹ (6.3)

³⁼¹ (6.5)

where, for the subject e:

y(^e)

• wⁱe is the estimation of r^e> obtained by the least squares method;

yl^e)

• ^BGM is the estimation of Y^e) obtained by the ridge method when the regularization parameter is selected by the BGH procedure;

• ^cv is the estimation of Ϋ^β> obtained by the ridge method when the regularization parameter is selected by the 10-fold cross-valisation; is the estimation of Y^e) obtained by the PLS1 method.

On the n_A first genes, and on the 40% remaining genes (i.e. n_T) which are not used for modellings, the inventors evaluated each procedure for each of the 54 modellings (e = 1 ,...,54) by the following empirical hazards

where Λ/ e {n_A, n_T}.

The interpretation of the criteria (6.6), (6.7), (6.8) and (6.9) is the following: the estimating quality of a procedure is the best when the associated criterion is the closest to 0. To compare the different estimation procedures, the inventors drew box plots corresponding to the following quantities distribution CRB CV 'RB CV 'RB CV With

(¾GH/mc,i> '

CRcv/mc 'Rcv/mc 'Rcv/mc With

{'Rpls/md ,

• CRpls 'Rpls 'Rpls With

K≠*/BGH,e = _ _(c) ^S , e = 1, . ^, . , 54 (6.14)

• CRpls/cv 'Rpls/cv 2?p/s/ci/,54) With

2.2. fiesu/fs

In the subsample associated with the n_A observations, the inventors obtained the results represented on Figure 12 and the corresponding statistics depicted in Table 9.

Table 9: Statistics associated with the box plots of Figure 12

N Statistics 'RsGH/cv 'ReGH/mc "Rcv/mc "Rpls/mc "Rpls "Rpls/cv

Minimum 0.9971 1.0000 1.0007 1.0192 1.0192 1.0182

Qi 0.9980 1.0000 1.0014 1.0413 1.0413 1.0390 n_A Q₂ 0.9983 1.0000 1.0018 1.0510 1.0510 1.0493

Q₃ 0.9987 1.0000 1.0021 1.0608 1.0608 1.0586

Maximum 0.9993 1.0002 1.0030 1.0867 1.0866 1.0852 Among the group of procedures, the least squares method justifies the best estimation performance on the 54 modellings: in Table 9, the criteria HeGH/mc, and Upts/mc are superior to 1 on all the modellings. On this same sample, the ridge method associated with the BGH procedure improves 100% of the modellings obtained with the ridge method associated with the 10-fold cross-validation since the criteria H_BGH_/CV is inferior to 1 on the 54 modellings. The PLS1 procedure, which only considers a latent variable for 98% of the modellings, is slightly less performant than the 3 other methods according to the evaluation criteria designed by the inventors.

In the subsample associated with the n_T observations, the results obtained are represented on Figure 13 and the corresponding statistics depicted in Table 10.

Table 10: Statistics associated with the box plots of Figure 13

In Table 10, the criteria 2 _SGH/mc and Hc_V/_mc are inferior to 1 for about 25% of the modellings. The least squares method is thus, for these examples, less performant than the ridge method (with BGH or the 10-fold cross-validation). The ridge method associated with the BGH procedure equals or even improves the ridge method associated with the cross-validation for 75% of the modellings. More specifically, the improvement of the cross-validation on BGH is not more than 0.4%, whereas the one of BGH on cross- validation is almost three times more important. PLS1 remains less performant than the 3 other procedures.

The estimated coefficients obtained with each procedure are represented on Figures 14 to 17.

According to these figures, the 4 modeling methods suggest a first group between the subpopulations

{fibroblasts, epithelial, vessels, CD14, CD19} = G^ and a second group between the subpopulations

{CD56, CD8, eosinophils, neutrophils} = G₂

For 79% of the reconstructions established with the least squares method, the highest coefficients are associated with variables defined by Gi . For 67% of the modellings realized with the least squares method, the highest coefficient is associated with the variable CD19. For 33% of the modellings, the variable fibroblasts is associated with the highest coefficient.

The inventors observed the same phenomena with the models obtained using the ridge method. Indeed, whatever the selection procedure used, for 44 of the 54 modellings, the highest coefficients are from the Gi group. 36 of the 54 modellings give the highest coefficient to CD19, and for the 18 other modellings, the variable fibroblasts is associated with the highest coefficient. It is not the case anymore when the coefficients are estimated using the PLS1 method, where only 26% of the reconstructions give to the variables from the Gi group the highest coefficients.

2.3. Discussion

The inventors designed an in silico method for decomposing the gene expression of different patterns from patients suffering from non-small cell lung cancer into specific subtypes of the associated tumoral stroma.

Technically, this method first includes a normalization step leading to obtaining a "pure" signature of gene patterns. Secondly, the inventors carried out a selection of genes in order to meet the mathematic correlations between the gene expressions of the subtypes of the tumoral stroma with biological reality. Finally, these different subtypes, also called subpopulations, were used to construct deconvolution models of the global gene signature of patients suffering from NSCLC. The results obtained with the different statistical methods used, namely the least squares method, the ridge method (with BGH or 10-fold cross-validation) and PLS1 , led to facts observed on the biological level.

In this study, the inventors demonstrated that the ridge method (with BGH or 10- fold cross-validation) was particularly more performant than PLS1 .

All the studied methods associate to the variables CD56, eosinophils and neutrophils low coefficients (close to 0 for 75% of the modellings obtained with the least squares method and the ridge method) and higher coefficients to the variables fibroblasts, epithelial, vessels, CD 14 and CD19.

The low proportions of CD56 and eosinophils in the tumoral stroma of lung cancer were confirmed by immunohistochemical results by the inventors. Similarly, the importance of the variable epithelial in the modellings meets immunohistochemical results. Example 2

This example demonstrates that the estimated coefficients associated with specific cell subpopulations of the tumor stromal environment enable determining a prognosis in patients suffering from lung cancer.

The characteristics of the cohorts studied by the inventors are described in Table 10 below.

Table 10: Characteristics of the cohorts studied in the present example.

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. h. vess. CD14 CD19

No surv. (years) Po fibro epit

CD56 neutro

(years)

GSE37745 (histology : ADC)

1 GSM1019139 1A 66 0 8,72279261 1 8,83013699 173,851752 0,30934644 0,21758328 0,12089836 0,13254215 0,4123484 0,0035783 -0,011341647

2 GSM1019140 1A 77 1 0,44353183 1 0,42191781 107,395422 0,22961208 0,40665445 0,09106613 0,17009051 0,61549931 0,017385 -0,036390349

3 GSM1019143 IB 40 1 1,52224504 1 1,28767123 28,3957212 0,50965567 0,30219326 0,10019182 0,08193599 0,56435113 0,02361367 -0,025530777

4 GSM1019144 3 68 1 0,83230664 1 0,24931507 -37,13742 0,73790528 0,20072848 0,08864523 0,1167893 0,85280471 0,01056108 0,000404941

5 GSM1019145 IB 65 1 1,61533196 0 0,60821918 -10,856685 0,67592437 0,22359159 0,09224069 0,09752615 0,76316321 0,01515217 -0,006461142

6 GSM1019147 IB 78 1 0,1670089 NA NA 44,1247769 0,40440344 0,40659304 0,14954328 0,23596456 0,54098837 0,0205015 0,011616052

7 GSM1019149 IB 74 1 1,62902122 NA NA 60,2108069 0,32666678 0,3596803 0,1371766 0,14845941 0,78293462 0,00981387 -0,034081271

8 GSM1019150 1A 71 1 5,0349076 NA NA 81,3182157 0,36975436 0,1789289 0,06255361 0,16030454 0,88063428 0,01033277 -0,032780491

9 GSM1019152 IB 54 1 1,43189596 NA NA 7,97113637 0,54477532 0,18140046 0,07827076 0,11704327 0,62463346 0,01896688 -0,003875758

10 GSM1019153 3 73 1 1,07597536 NA NA 63,8511206 0,3938137 0,33815024 0,17629931 0,15011113 0,31381424 0,01258018 0,013846457

11 GSM1019154 4 56 1 0,6844627 NA NA 37,9722691 0,38135043 0,12153488 0,05869661 0,08007878 0,7848362 -0,0011198 -0,014269671

12 GSM1019158 IB 70 1 1,34154689 1 1,19726027 -17,396693 0,93308121 0,35017265 0,12494533 0,19210503 0,53886193 0,01333079 -0,023322837

13 GSM1019160 IB 72 1 0,22997947 0 0,22739726 56,8429318 0,43874447 0,15326235 0,07384397 0,12376581 0,89789848 0,00441324 -0,021165983

14 GSM1019162 IB 70 1 0,97193703 0 0,98356164 85,271345 0,4963955 0,26266337 0,10724459 0,17751425 0,69733914 -0,0065255 0,012612005

15 GSM1019163 2 74 1 0,24093087 NA NA 293,173132 0,28639762 0,3275006 0,06563746 0,01823946 0,2207073 -0,0342386 -0,029615782

16 GSM1019164 3 54 1 0,78302533 1 0,65479452 2,21793116 0,51903719 0,35614962 0,10159318 0,18865548 0,92604466 0,02500382 0,038972511

17 GSM1019165 2 71 1 0,41341547 0 0,14794521 97,2595784 0,21183913 0,14697129 0,07508227 0,18002746 0,56610025 0,05015148 0,110233513

18 GSM1019166 IB 70 1 5,77138946 1 3,06575342 44,9527752 0,2430623 0,36243728 0,22143088 0,11580595 0,06578913 0,01806705 0,004779352

19 GSM1019169 3 75 1 9,50034223 0 9,26849315 108,528054 0,50628048 0,20800164 0,06863972 0,11606832 0,81703599 -0,0127628 -0,017223937

20 GSM1019170 IB 69 1 11,0335387 0 11,0712329 17,3681298 0,33555617 0,20388724 0,07782228 0,1240803 0,83295593 0,03776857 -0,012784631

21 GSM1019171 1A 62 1 8,92539357 0 6,93424658 98,8694843 0,21561507 0,2835741 0,11244101 0,18635065 0,47963651 0,02886821 0,000555121

22 GSM1019174 2 66 1 1,4072553 1 1,37808219 46,5567804 0,62704767 0,17297183 0,06566528 0,10709045 0,83293813 0,00332047 0,03340272

23 GSM1019175 1A 56 0 15,6386037 0 8,09315068 78,4350494 0,48037817 0,32602944 0,09336692 0,10140368 0,57522304 0,00269462 -0,006686123

24 GSM1019176 IB 76 1 0,76933607 1 0,67671233 92,633827 0,65383381 0,30873092 0,09840874 0,20373837 0,71866987 -0,0051277 -0,045939279

25 GSM1019180 IB 66 1 0,93908282 1 0,31780822 17,9610629 0,41350794 0,23293186 0,07298382 0,11959265 0,41496601 0,03602595 0,042875015

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fibro epith. vess. CD14 CD19

No surv. (years) Po CD56 neutro

(years)

26 GSM1019181 1A 52 1 8,81861739 1 7,06575342 40,2623334 0,37860417 0,32973425 0,11115101 0,23244324 0,62149972 0,02497567 -0,013569877

27 GSM1019183 IB 51 1 1,61806982 1 0,52054795 57,5693484 0,31363234 0,0834757 0,07863886 0,13727338 0,68142433 0,01502364 -0,010232784

28 GSM1019185 2 62 1 10,1820671 1 7,95890411 92,7372582 0,29450156 0,2553523 0,09717876 0,15584777 0,74290369 0,01286271 0,000616951

29 GSM1019186 2 64 0 10,5242984 0 5,71506849 141,722402 0,39218452 0,11300431 0,03749256 0,08388465 0,79830747 0,00590429 -0,029422545

30 GSM1019187 IB 82 1 9,11978097 1 4,67671233 6,48967123 0,51896501 0,18732341 0,08165571 0,10660974 0,4618937 0,01614122 -0,015937036

31 GSM1019188 IB 55 0 10,1930185 0 2,64657534 70,5204027 0,2514299 0,13130129 0,15900212 0,081207 0,9220994 0,01628047 -0,023294038

32 GSM1019190 IB 71 0 9,9137577 0 4,73424658 41,7081371 0,32651893 0,27832727 0,18224153 0,18393296 0,96638397 0,0177287 -0,037418044

33 GSM1019192 1A 75 0 9,2238193 0 4,72876712 43,3524572 0,51431493 0,29230011 0,12242209 0,11807156 0,98052508 0,0089101 -0,03036598

34 GSM1019194 3 74 1 ₇,₇8644764 0 7,89863014 -59,581456 0,87040434 0,19512686 0,13920438 0,14189959 0,74602934 0,01409484 -0,032431549

35 GSM1019196 3 59 1 0,0164271 0 0,01643836 -21,411781 0,50207228 0,30681374 0,14578417 0,13671445 0,75318972 0,02012343 -0,012145234

36 GSM1019197 IB 59 1 0,53661875 1 0,36438356 42,2114652 0,45382297 0,05102657 0,03231432 0,13259656 0,53214705 -0,0010303 -0,011970841

37 GSM 1019200 2 51 1 0,96098563 NA NA 84,7164037 0,26141974 0,35428291 0,04739684 0,1240102 0,39374437 0,00579598 0,024257713

38 GSM 1019203 2 70 1 0,21629021 NA NA 47,1678964 0,38450498 0,26431993 0,10581436 0,1568459 0,67789683 0,01002267 -0,01291116

39 GSM 1019204 2 70 1 10,8117728 1 6,52054795 170,961765 0,16261667 0,31651237 0,09708039 0,02987393 0,32340545 -0,0096166 0,059329018

40 GSM 1019205 1A 59 0 12,8761123 0 13,6383562 35,7833273 0,57047573 0,18861324 0,1187104 0,22465186 0,82345926 0,01808413 -0,020226112

41 GSM 1019207 IB 57 1 0,67624914 NA NA 35,7340596 0,34229065 0,09983594 0,05092415 0,01124201 0,7830992 0,01416761 0,072766189

42 GSM1019210 1A 66 1 7,52361396 0 7,53424658 -8,8661821 0,45590792 0,25515253 0,10929073 0,15834323 0,77259308 0,01158096 -0,005598829

43 GSM1019211 3 60 1 0,8843258 1 0,83835616 -7,6613363 0,76957979 0,24990138 0,11608042 0,21139245 0,69451431 0,01674369 0,032317143

44 GSM1019213 IB 61 0 12,2902122 1 10,3013699 -11,483996 0,48905028 0,27031811 0,06286115 0,16256215 0,56578582 0,03615467 0,040009224

45 GSM1019214 1A 55 0 12,2819986 0 5,70958904 101,074275 0,37577849 0,37413956 0,10236374 0,17492864 0,73902812 0,00490479 -0,029615665

46 GSM1019216 3 59 1 1,08418891 1 0,50684932 66,6374633 0,42103615 0,15235867 0,06758457 0,05955917 0,28989693 0,00051708 -0,00995157

47 GSM1019217 4 70 1 1,01300479 1 0,58082192 -35,217464 0,48012746 0,47923138 0,0853439 0,07770957 0,51965608 0,02285298 0,004015751

48 GSM1019218 IB 67 1 0,71731691 1 0,49041096 98,3525085 0,3995894 0,09462648 0,05411522 0,27779663 0,54033989 0,03741242 -0,003051018

49 GSM 1019220 2 64 1 1,45927447 1 0,37808219 -92,260373 0,39709012 0,47886454 0,06800569 0,15800704 0,88030372 0,03313784 -0,003881894

50 GSM 1019224 2 49 1 5,13073238 1 0,69863014 29,8227232 0,5418608 0,33004188 0,083508 0,09028758 0,55212768 0,00415561 -0,005900179

51 GSM 1019225 2 51 1 0,48459959 0 0,01917808 89,0086199 0,51128224 0,12318198 0,05707043 0,18005673 0,75913591 0,0681899 0,002821807

52 GSM 1019228 IB 54 0 13,9137577 NA NA 33,6376687 0,59559278 0,27027281 0,07111069 0,21934689 0,87032006 0,03352064 -0,030363385

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fibro epith. vess. CD14 CD19

No surv. (years) Po CD56 neutro

(years)

53 GSM1019230 3 68 1 6,56262834 0 6,2109589 41,5175478 0,47435161 0,27214309 0,10860942 0,11859191 0,84482887 0,01481887 -0,023947108

54 GSM1019234 IB 51 1 5,66187543 1 1,70410959 20,1758185 0,53525288 0,23480169 0,09044721 0,1661939 0,77761632 0,01094009 -0,000521766

55 GSM1019236 2 47 1 9,70568104 1 8,68219178 90,4522155 0,43788584 0,26980136 0,08701687 0,08647428 0,74666727 -0,0059946 -0,003206838

56 GSM1019239 IB 55 1 3,34565366 NA NA 13,3125351 0,48670237 0,15700781 0,06189506 0,08360502 0,5611797 0,03174847 0,007581077

57 GSM 1019242 IB 66 0 8,83504449 0 5,71506849 58,391737 0,41245601 0,37514779 0,13466517 0,17229381 0,77069059 0,02997951 -0,050802055

58 GSM 1019243 IB 60 1 2,82272416 NA NA -33,972578 0,51537712 0,34470826 0,07121833 0,16400577 0,8289195 0,01465468 -0,026050499

59 GSM 1019244 1A 57 1 3,40314853 NA NA 77,376103 0,32528401 0,28503391 0,07436142 0,15372285 0,69161295 0,01026697 -0,040066497

60 GSM 1019247 3 60 1 3,07460643 NA NA 40,7612171 0,71248139 0,33707244 0,04929026 0,18533221 0,6438757 0,01808788 -0,010982008

61 GSM 1019249 1A 73 0 7,84668036 NA NA 110,841006 0,47589704 0,32442455 0,07647314 0,13357272 0,86444835 0,03077158 -0,003737164

62 GSM1019253 IB 64 1 2,34633812 NA NA -14,000315 0,44748838 0,38295955 0,09563346 0,13118122 0,70592439 0,01503214 -0,024315894

63 GSM 1019254 1A 56 0 7,55920602 NA NA 71,8840032 0,67111714 0,22746558 0,1137617 0,10357557 0,89204724 0,01779491 0,003769469

64 GSM1019256 IB 74 1 2,28884326 NA NA 141,054618 0,35678693 0,29763519 0,02118289 0,04558669 0,64238943 -0,0071148 0,009458097

65 GSM 1019257 1A 78 1 3,25804244 NA NA 29,4826646 0,44689047 0,34134537 0,14634907 0,14381342 0,60149425 0,03347411 -0,027953526

66 GSM1019258 1A 58 1 5,94113621 NA NA 169,187341 0,33721199 0,29252997 0,08746574 0,13611102 0,21573223 0,01171228 -0,016297256

67 GSM 1019259 3 54 0 7,08829569 NA NA 19,384431 0,36541043 0,32037898 0,19432432 0,16193273 0,67154884 0,00041453 0,019228934

68 GSM1019260 IB 49 0 6,43394935 NA NA -23,795406 0,70508245 0,26368923 0,11935508 0,12428936 0,95084815 0,03511953 -0,001006594

69 GSM1019261 1A 53 0 6,31895962 NA NA -29,265185 0,36918476 0,11995515 0,06552185 0,13848719 0,73083392 0,0176306 -0,018646186

70 GSM 1019264 3 67 1 3,2991102 NA NA 102,548361 0,37989127 0,38665185 0,09776719 0,12641687 0,34971455 0,01924183 -0,025793977

71 GSM1019265 1A 51 0 6,34086242 NA NA -21,010923 0,6508223 0,23668387 0,11692842 0,17412078 0,75485776 0,01629608 -0,020026543

72 GSM1019268 1A 53 0 6,70225873 NA NA -39,033687 0,43058581 0,24440868 0,1209499 0,09830527 0,90106369 0,01226095 -0,016129901

73 GSM 1019270 3 66 1 2,73785079 NA NA 104,997932 0,32221175 0,56827724 0,13427827 0,10528493 0,38450604 -0,0029253 -0,028631048

74 GSM 1019272 1A 65 1 3,35112936 NA NA 27,2760512 0,46024049 0,43002563 0,11485867 0,09476971 0,65530042 0,00473539 -0,02842424

75 GSM1019273 1A 55 1 4,0054757 NA NA 42,6299367 0,43891478 0,23839205 0,06864354 0,16715246 0,20177868 0,01865952 0,037964372

76 GSM 1019274 1A 57 1 0,13689254 NA NA -18,146179 0,37689432 0,3597351 0,18498586 0,13100049 0,63425503 0,00276292 -0,022901856

77 GSM 1019275 IB 75 1 0,8733744 1 0,44383562 67,9900122 0,78593854 0,25603461 0,09767236 0,18618192 0,58294396 0,01124517 -0,028053856

78 GSM1019283 IB 68 0 5,27857632 NA NA 54,0071444 0,72296433 0,28689972 0,08993078 0,14946043 0,75977608 0,00669486 -0,0427716

79 GSM1019285 2 47 0 4,99931554 NA NA 102,353598 0,49998831 0,1274242 0,04495665 0,13230672 0,89436947 0,00503119 0,005942998

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fib epith. vess. CD14 CD19

No surv. (years) Po ro

CD56 neutro

(years)

80 GSM1019286 IB 67 1 2,0698152 NA NA 35,492719 0,57745301 0,20383296 0,08941062 0,18715495 0,70706444 0,01196988 0,000729669

81 GSM1019288 IB 60 0 5,08966461 NA NA 24,3260042 0,79250788 0,27764599 0,05897582 0,13772466 0,552125 0,02492534 -0,004088596

82 GSM1019289 IB 78 1 2,76796715 NA NA 9,13079198 0,81892781 0,21868916 0,09761997 0,12185914 0,87349559 0,00825266 -0,016732223

83 GSM 1019290 IB 79 1 4,10677618 NA NA 31,7297337 0,44270445 0,21642468 0,13299659 0,13530087 0,70319908 0,0172824 -0,023520561

84 GSM 1019292 1A 67 1 3,23340178 NA NA 72,556605 0,24440668 0,08173819 0,06048381 0,10889355 0,64796713 -0,0024027 -0,012871822

85 GSM 1019295 IB 67 0 13,0321697 0 13,8410959 27,2406587 0,6942935 0,29650374 0,07763787 0,10087006 0,96154413 -0,0006146 0,000458536

86 GSM1019298 2 57 1 2,75701574 NA NA 153,256983 0,23432235 0,11403389 0,03436464 0,11376027 0,23997862 0,00590803 0,008569171

87 GSM 1019299 2 51 1 4,40793977 NA NA 63,0581493 0,47660596 0,27938606 0,16974584 0,09982014 0,645877 0,00202899 -0,005837634

88 GSM1019300 IB 73 1 3,74264203 NA NA 244,459203 0,1100733 0,58122812 0,02775262 0,05147318 0,39376183 -0,0049006 -0,055234026

89 GSM1019302 1A 62 0 11,137577 0 6,49041096 -20,011518 0,41595719 0,39675024 0,19250111 0,19384113 0,77631993 0,02538287 -0,034326632

90 GSM1019303 IB 52 1 2,0971937 NA NA 122,683712 0,30097641 0,29260119 0,09824261 0,05852209 0,23898315 0,00577416 0,0217494

91 GSM1019305 1A 67 0 10,5297741 0 11,1561644 7,45217263 0,58537276 0,23743949 0,07987836 0,07717034 0,81316129 0,01574366 -0,024035907

92 GSM1019308 2 71 1 3,34291581 NA NA 52,4446441 0,59308571 0,27763483 0,08291636 0,17623862 0,85726116 0,01130108 -0,03900824

93 GSM1019309 IB 83 1 2,68035592 NA NA 70,0355928 0,43830044 0,30220377 0,06681987 0,17301057 0,78602594 0,02308221 -0,026208233

94 GSM1019310 4 63 0 8,80766598 NA NA 48,0814146 0,33575523 0,39980038 0,22073659 0,06936857 0,29872214 0,021322 -0,012156461

95 GSM1019311 1A 65 1 4,61875428 NA NA 4,45359768 0,51718983 0,2406831 0,14090118 0,23828895 0,74875594 0,03022926 -0,025938804

96 GSM1019312 4 72 1 5,93292266 NA NA -101,62405 0,72334434 0,44208384 0,10146738 0,14629036 0,78032293 0,04295167 -0,032213723

97 GSM1019313 1A 49 0 13,8617385 0 13,8219178 25,1885247 0,50905439 0,2342443 0,06557429 0,09982987 0,79630612 0,01130587 -0,019514917

98 GSM1019314 2 66 0 13,4072553 0 2,38082192 -5,3882256 0,62295411 0,20697329 0,05141799 0,281713 0,91830351 0,05732505 0,033706914

99 GSM1019316 IB 70 1 3,95619439 NA NA -34,009965 0,25813823 0,34612143 0,03807415 0,08796493 0,75479469 0,01761565 -0,004802802

100 GSM1019318 2 54 1 5,63997262 NA NA -17,32296 0,60245905 0,37587447 0,09379877 0,09523686 0,86505561 0,01626817 0,007983436

101 GSM1019320 IB 52 1 4,07392197 NA NA 36,3388246 0,33951985 0,35572822 0,21234475 0,07133352 0,81126857 0,01023063 -0,033095396

102 GSM1019321 IB 54 0 14,255989 0 14,8575342 -40,768712 0,45542796 0,1578123 0,07457026 0,16943554 0,85633656 0,07172012 0,069711137

103 GSM1019324 IB 67 1 7,69336071 0 1,45479452 78,241763 0,59868383 0,34180237 0,07722031 0,1282883 0,230979 0,02018551 0,022493474

104 GSM1019328 1A 59 1 3,04722793 NA NA 3,55792385 0,78249962 0,2992397 0,09739955 0,14077838 0,50287922 0,01372754 -0,003561472

105 GSM1019330 1A 53 0 6,88569473 NA NA -60,628743 0,50348451 0,36557551 0,12880224 0,1099261 0,84084673 0,01911528 0,010359509

106 GSM1019332 2 47 1 2,77891855 NA NA 68,2957915 0,40805156 0,29525971 0,10788858 0,14019495 0,83103886 0,01131453 -0,031596287

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv.

surv. (years) Po fibro epith. vess. CD14 CD19

No CD56 neutro

(years)

GSE50081 (histology : ADC)

107 GSM1213670 1A 68,15 0 7,52 0 7,521 -22,109835 0,43910841 0,28675054 0,08817479 0,29778685 0,66010355 0,17081232 -0,04110547

108 GSM1213671 IB 69,15 0 7,32 0 7,324 28,2065598 0,45572248 0,39644916 0,16876617 0,16646055 0,53514761 0,04805448 -0,032526539

109 GSM1213672 1A 82,36 0 6,84 0 6,842 25,4852694 0,79105919 0,23949013 0,06880177 0,19562818 0,89839854 0,04096418 -0,048564882

110 GSM1213673 IB 68 1 1,91 1 1,613 -47,624318 1,11747576 0,13536565 0,1131755 0,19795923 0,29955976 0,0252832 -0,005025319

111 GSM1213676 IB 71,43 1 4,33 1 4,156 21,6733597 0,34627708 0,15811697 0,05214986 0,10614862 0,59682202 0,11847276 0,002422679

112 GSM1213677 IB 44,21 0 6,22 0 6,218 71,5075464 0,62268556 0,19891804 0,03209732 0,08078084 0,77050738 0,00535433 -0,034120682

113 GSM1213678 2 74,16 1 4,08 1 3,743 -25,296545 0,81486722 0,18147845 0,13003471 0,23587744 0,6685776 0,03270571 -0,019804971

114 GSM1213679 1A 66,46 0 6,31 0 6,311 84,6266263 0,70442503 0,31206549 0,15371529 0,17840168 0,85533268 0,01882042 -0,053094119

115 GSM1213680 IB 59,01 0 5,99 0 5,988 29,5491348 0,56693535 0,19117771 0,08022071 0,18305942 0,76370562 0,04804425 -0,024211308

116 GSM1213681 IB 70,56 0 5,32 0 5,317 75,9791244 0,44241007 0,29554394 0,04279047 0,03146607 0,78823708 0,01631345 0,000518631

117 GSM1213682 1A 72,96 0 5,56 0 5,561 27,4199451 0,60320078 0,19055834 0,10053195 0,11643681 0,91178042 0,03032081 -0,00424302

118 GSM1213683 IB 79,28 0 5,02 0 5,018 -61,404194 0,83876592 0,3964524 0,12222315 0,11381432 0,72298377 0,04793918 -0,018617327

119 GSM1213685 1A 52,14 0 6,76 0 6,757 42,9524225 0,53664663 0,28938517 0,15368597 0,14053236 0,72933023 0,01857455 -0,031678545

120 GSM1213686 IB 85,78 1 2,84 0 2,836 37,3083307 0,5642809 0,20259238 0,05339688 0,16939369 0,4990504 0,04327058 -0,015966067

121 GSM1213687 IB 76,93 0 6,46 0 6,456 -79,646998 0,40567525 0,52420794 0,18073876 0,13214986 0,66866559 0,04652963 -0,035110682

122 GSM1213688 1A 73,23 0 5,76 0 5,758 46,961659 0,57252833 0,30520368 0,09097893 0,07346072 0,21214823 0,03396094 -0,004828818

123 GSM1213689 1A 77,18 0 4,95 0 4,95 -60,661649 0,37430473 0,3541676 0,20058837 0,33037367 0,8575418 0,06451799 -0,035989034

124 GSM1213690 2 78,96 0 5,12 1 4,882 -2,8314559 0,51401366 0,30156669 0,07615234 0,16501837 0,57486724 0,02338264 -0,016931406

125 GSM1213691 IB 78,99 0 6,39 0 6,393 76,4649218 0,60712095 0,13502384 0,06922056 0,09273835 0,88496298 -0,0054548 -0,015449362

126 GSM1213692 1A 55,39 1 5,74 0 5,744 38,6824792 0,41090492 0,25028215 0,11180144 0,14361157 0,71504901 0,03455192 -0,01858924

127 GSM1213693 2 61,53 1 1,1 1 0,709 42,762672 0,32098295 0,242177 0,08962086 -0,0042367 0,13054112 0,00502111 0,029023254

128 GSM1213694 2 68,66 0 6,69 1 3,102 -19,775672 1,14415679 0,23237738 0,04620317 0,22742799 0,50296859 0,02695011 -0,043284652

129 GSM1213695 2 62,9 0 5,84 0 5,843 42,8659288 0,52785415 0,20557845 0,07198255 0,18748676 0,89644434 0,09469758 -0,00916856

130 GSM1213696 IB 67,04 0 5,18 0 5,18 30,4964763 0,57456344 0,3618543 0,16230493 0,16715289 0,83189371 0,0287439 -0,045924235

131 GSM1213697 IB 79,71 0 6,37 0 6,368 66,2051376 0,51048402 0,24864555 0,29883385 0,1760486 0,89765245 0,05261385 -0,034060422

132 GSM1213698 2 69,59 1 5,63 0 5,634 57,1103131 0,77323797 0,1152994 0,08875829 0,13121291 0,98324269 0,11529864 -0,012390188

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. o epith. vess. CD14 CD19

No surv. (years) Po fibr

CD56 neutro

(years)

133 GSM1213699 1A 61,13 1 1,88 1 1,325 144,606159 0,35130015 0,29017378 0,10922527 0,19375386 0,71497108 0,02747304 -0,043912739

134 GSM1213700 IB 73,93 1 4,03 1 1,87 41,4527014 0,64704043 0,29101645 0,10801226 0,16022471 0,84585001 0,01750744 -0,026325078

135 GSM1213702 2 55,75 1 2,93 0 2,927 -13,233799 0,5602869 0,16312589 0,04535723 0,10696385 0,70188064 0,01893615 -0,017160833

136 GSM1213703 IB 75,68 1 5,96 1 5,752 137,705513 0,40600513 0,26956846 0,13769201 0,10994589 0,46341836 0,02527268 0,009478293

137 GSM 1213704 2 61,59 0 5,54 1 4,964 56,4332644 0,46921405 0,34347435 0,07778173 0,13008674 0,48425241 0,02750913 -0,016552121

138 GSM1213707 IB 41,95 0 5,41 1 1,725 -30,058957 0,82301913 0,30315941 0,13393415 0,1329982 0,7936632 0,03852148 -0,009373843

139 GSM1213710 2 67,56 0 0,33 1 0,214 -4,6668272 0,50323749 0,13725129 0,0699553 0,25529879 0,8149582 0,13735299 0,05567343

140 GSM1213715 2 72,97 0 7,36 1 4,022 -14,559534 0,76990535 0,11634575 0,05164109 0,0867396 0,85865222 0,0413834 -0,03064421

141 GSM1213716 IB 73,57 1 4,37 1 4,367 89,7233495 0,56200688 0,47161857 -0,0040751 0,08422397 0,79431416 0,00406822 -0,047728787

142 GSM1213717 IB 63,41 1 4,91 1 3,608 -53,44197 0,57580695 0,31050841 0,05210985 0,15223541 0,62039699 0,07125393 0,002193148

143 GSM1213720 1A 67,6 0 6,37 0 6,371 32,8071119 0,74137583 0,30666216 0,13848053 0,14491659 0,66988754 0,02096294 -0,038680202

144 GSM1213722 IB 68,87 1 1,25 1 0,583 -117,74758 1,04972995 0,18353948 0,13028979 0,17011277 0,71927083 0,05353765 -0,010578836

145 GSM1213723 2 79,65 1 2,61 1 2,229 19,1560794 0,55151555 0,15599257 0,08513971 0,1720676 0,94052923 0,07057537 -0,036570522

146 GSM 1213724 1A 76,91 0 6,28 0 6,283 121,412633 0,24901073 0,46466859 0,1480265 0,03557842 0,17773589 0,01508201 -0,012469343

147 GSM1213726 2 83,65 0 6,56 0 6,563 9,19543529 0,71641527 0,31237397 0,10548707 0,22885841 0,73599254 0,03739044 -0,048244064

148 GSM1213727 2 49,24 1 5,79 1 1,791 25,1762571 0,81190318 0,22609097 0,07281855 0,21264839 0,9256749 0,07809318 -0,029915205

149 GSM1213728 1A 75,89 0 5,39 0 5,388 17,4237576 0,7300523 0,27369598 0,15179592 0,14652084 0,90292134 0,01223771 -0,038756889

150 GSM1213730 IB 65,26 1 3,21 1 0,799 -97,128694 0,78651918 0,36299114 0,10968166 0,17210521 0,57938476 0,0655979 -0,000603962

151 GSM1213733 IB 78,13 1 3,48 1 2,708 -75,85678 0,51673498 0,46680434 0,164427 0,13473477 0,55536274 0,02437936 -0,021204301

152 GSM1213734 2 71,23 0 5,16 0 5,161 68,3087808 0,46686596 0,35521068 0,10822898 0,09646328 1,01923705 0,03955394 -0,054926376

153 GSM1213735 IB 68,14 0 6,06 1 1,232 -79,483419 0,78642111 0,38254991 0,08916872 0,12675944 0,7605093 0,01408534 -0,031106189

154 GSM1213736 IB 54,09 1 0,91 1 0,887 50,5160663 0,80633097 0,19038739 0,11219175 0,27631171 0,78018965 0,07205899 -0,031076506

155 GSM1213737 1A 64,19 0 2,95 0 2,946 13,5814497 0,46043772 0,34322212 0,08175033 0,05567241 0,78350212 0,00161909 -0,042816725

156 GSM1213738 2 63,5 1 3,85 0 3,852 -40,432406 0,5646911 0,44300194 0,14200698 0,1217944 0,86373162 0,03250045 -0,022818085

157 GSM1213739 IB 74,91 0 0,12 0 0,12 -53,855406 0,71446757 0,19824664 0,09991329 0,19341299 0,74390591 0,02983333 -0,020393972

158 GSM 1213740 IB 85,91 0 5,84 0 5,843 26,2361234 0,61557869 0,31452727 0,09471269 0,15880575 0,94951747 0,0372826 -0,045061591

159 GSM1213741 IB 80,61 1 6,35 0 6,352 52,9846252 0,4340475 0,36406184 0,13179542 0,13273183 0,50739591 0,03838198 -0,031418177

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. ro epith. vess. CD14 CD19

No surv. (years) Po fib

CD56 neutro

(years)

160 GSM 1213742 2 80,76 1 5,26 0 5,259 9,85495208 0,97165613 0,20812014 0,10122175 0,11631679 0,78952475 0,00946307 0,01021678

161 GSM1213743 IB 40,16 0 5,03 0 5,032 -7,494557 0,25750146 0,24345863 0,16735871 0,1498997 0,8280476 0,02931413 -0,030667308

162 GSM1213746 IB 60,79 0 5,17 0 5,175 -53,545716 0,59436711 0,41069105 0,15133559 0,19644937 0,91769647 0,05191862 -0,040839341

163 GSM 1213747 2 57,09 0 4,13 0 4,129 41,1781033 0,71791834 0,27777657 0,1552298 0,09399896 0,90337707 0,00469828 -0,04282763

164 GSM 1213749 IB 78,26 1 3,2 1 1,216 26,4618062 1,03842384 0,33174584 0,08552727 0,12331634 0,93090296 0,03291986 -0,054393879

165 GSM1213750 2 50,12 1 1,03 1 0,923 -57,497023 0,84745539 0,16431206 0,06915347 0,1513629 0,54763495 0,04332952 0,00088174

166 GSM1213751 1A 49,86 0 4,91 0 4,912 -18,346649 0,62024888 0,3569043 0,1661271 0,16393091 0,7884479 0,05659955 -0,040961186

167 GSM1213752 IB 64,73 1 0,97 1 0,821 14,4913776 0,39552989 0,36406889 0,08469232 0,15526092 0,71343527 0,02968666 -0,031910463

168 GSM1213753 IB 80,78 1 3,09 1 2,732 50,4341456 0,38228381 0,41071198 0,15996768 0,09789995 0,36667119 0,02682211 -0,038590958

169 GSM1213754 2 72,96 1 2,02 1 0,701 -56,870225 0,87152442 0,23816345 0,14934715 0,13271752 0,75611776 0,02152987 -0,00605042

170 GSM1213756 1A 60,85 0 5,27 0 5,273 4,7394907 0,76980831 0,23610422 0,16313504 0,21943801 0,83910212 0,01774901 -0,049267508

171 GSM1213757 IB 69,77 0 5,75 1 0,274 -120,37952 0,80353563 0,43285429 0,12891061 0,22473788 0,80844454 0,09927777 -0,022691721

172 GSM1213758 IB 61,98 0 5,51 1 2,119 53,1703618 0,68978379 0,19849557 0,21533448 0,11976932 0,92880514 0,03167544 -0,052084431

173 GSM1213759 IB 49,41 0 5,49 0 5,495 -1,4792001 0,29904275 0,39268456 0,09358638 0,08125753 0,30950201 0,02972387 -0,014145271

174 GSM1213760 1A 78,11 0 4,57 0 4,575 -78,097726 0,62784392 0,33264464 0,12543322 0,12750942 0,71207991 0,03407484 -0,008614578

175 GSM1213761 1A 63,1 0 4,93 0 4,928 54,76272 0,31193738 0,364015 0,20223871 0,08625998 0,71935609 0,02670619 -0,026978785

176 GSM1213762 2 57,68 1 0,86 1 0,112 -68,350149 0,7043111 0,20578532 0,09267894 0,22605608 0,80232053 0,08598332 -0,008558713

177 GSM1213763 IB 62,23 1 1,95 0 1,955 47,8407385 0,64142602 0,1128318 0,07605213 0,24402739 1,00716978 0,09235832 -0,010546392

178 GSM1213764 IB 63,54 0 7,75 0 7,745 -10,21931 0,61936628 0,25770864 0,12000223 0,17012403 0,91920104 0,05478716 -0,04353283

179 GSM1213768 IB 60,6 0 4,34 0 4,345 39,7757917 0,47406395 0,21218845 0,09979215 0,10364829 0,89470533 0,02090339 -0,03213601

180 GSM1213769 1A 57,75 0 5,29 1 3,721 -16,074345 0,64961468 0,27995034 0,14656893 0,22556719 0,81686608 0,07211597 -0,045093841

181 GSM1213770 2 68,59 1 2,11 0 2,108 41,0178957 0,66905715 0,14047799 0,10900862 0,16580802 0,93729335 0,0508203 -0,035704582

182 GSM1213773 IB 69,43 1 4,79 0 4,794 -27,006291 0,89535968 0,2987431 0,18009808 0,15438363 0,86847002 0,03330887 -0,004999408

183 GSM1213774 2 68,25 1 3,01 1 2,888 41,9124926 1,04456502 0,16444171 0,102769 0,21138217 0,85903267 0,05326844 -0,020366552

184 GSM1213775 1A 70,52 1 3,14 0 3,143 66,0691532 0,19663397 0,17651061 0,08400027 0,25031487 0,8590335 0,08739683 -0,016175091

185 GSM1213776 2 70,73 1 1,21 0 1,213 11,2056564 0,58491976 0,06271608 0,05050802 0,23243303 0,56360434 0,08273097 -0,028024634

186 GSM1213777 IB 66,69 0 5,45 0 5,446 6,86054352 0,40893164 0,1059998 0,07465477 0,13922037 0,84075454 0,03317775 -0,037623384

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. ro epith. vess. CD14 CD19

No surv. (years) Po fib

CD56 neutro

(years)

187 GSM1213779 IB 73,02 0 3,11 0 3,107 61,0222066 0,30875888 0,3725202 0,15805387 0,15875429 0,88883856 0,06033242 -0,032779745

188 GSM1213780 1A 84,19 1 0,65 0 0,654 -5,0910071 0,75883025 0,26642504 0,09967486 0,17837279 0,78477578 0,03298182 -0,014258475

189 GSM1213781 2 70,96 1 1,8 0 1,796 10,7655048 0,99295475 0,0564325 0,12793321 0,32615335 0,66530014 0,05469349 -0,045846624

190 GSM1213782 1A 74,74 0 3,21 0 3,214 5,70574095 0,46485862 0,40872131 0,09861674 0,1717431 0,70744366 0,06084261 -0,039096295

191 GSM1213783 1A 83,58 1 0,6 0 0,6 -57,843001 0,61262535 0,22777109 0,09736355 0,34232713 0,65239251 0,14417465 -0,010765323

192 GSM1213784 1A 66,38 0 5,2 0 5,205 9,52544985 0,46330346 0,36418913 0,16605819 0,10212664 0,82413134 0,02247764 -0,034028836

193 GSM1213785 1A 73,63 1 3,89 1 2,94 6,63844119 0,65812723 0,08371283 0,03949011 0,06699566 0,90835867 0,01651307 -0,046582541

194 GSM1213787 IB 71,22 0 3,43 1 2,913 47,3710017 0,70590271 0,12957187 0,16441709 0,274559 0,99664862 0,05460625 -0,04905008

195 GSM1213788 2 80,54 1 1,49 1 1,191 17,3772804 0,97609211 0,13057326 0,0678634 0,21793139 0,75808757 0,0253323 -0,004824392

196 GSM1213792 IB 79,62 1 2,92 0 2,916 32,1520527 0,62914443 0,29694967 0,10758199 0,16261316 0,55900962 0,02964389 0,002635346

197 GSM1213793 IB 72,67 0 2,69 0 2,686 56,9540335 0,34940119 0,06658404 0,0650405 0,21310224 0,83642122 0,14505744 -0,035516368

198 GSM1213794 1A 56,71 0 4,99 0 4,988 5,81239564 0,28783695 0,37405827 0,12197647 0,13155184 0,72437118 0,04905581 -0,036744664

199 GSM1213795 1A 60,29 0 6,67 0 6,675 31,3292752 0,6095536 0,28358498 0,25745822 0,17031351 0,67920775 0,01789729 -0,034290068

200 GSM1213797 1A 70,91 0 5,84 0 5,837 73,4576424 0,44158367 0,41041688 0,19466721 0,09843431 0,73644682 0,02047161 -0,02611378

201 GSM1213798 IB 75,03 0 10,88 NA 0,019 32,9625701 0,49142937 0,23895488 0,12285938 0,09731674 0,93844189 0,02895396 -0,022106227

202 GSM1213800 1A 84,48 0 0,51 0 0,515 5,05774083 0,99670967 0,26182157 0,05993979 0,17705004 0,86385489 0,01374459 -0,040304325

203 GSM1213801 2 76,94 1 4,04 NA 0,027 1,76951185 0,75923552 0,08299534 0,06167462 0,15447909 0,89464381 0,15967501 -0,014956906

204 GSM1213803 IB 73,69 0 1,54 0 1,536 -30,622013 0,80878027 0,21456648 0,15135427 0,17975644 0,7231623 0,05884472 -0,03076176

205 GSM1213804 IB 80,83 0 7,83 0 7,833 6,35159985 0,87257101 0,3245524 0,10310124 0,11454293 0,32690491 0,02154509 -0,00308455

206 GSM1213805 IB 47,09 0 6,02 0 6,021 22,5481026 0,74460232 0,15942672 0,07437729 0,23146409 0,92203202 0,12535141 -0,020605554

207 GSM1213806 IB 69,03 0 1,71 0 1,714 -11,3527 0,65967786 0,14366404 0,0530251 0,32894018 0,73526895 0,10323807 -0,006401658

208 GSM1213807 2 69,92 0 0,71 0 0,706 32,128005 0,69747834 0,22309528 0,03029869 0,19493328 0,72737518 0,04283166 -0,02160808

209 GSM1213808 1A 48,8 0 5 0 5,005 56,6761623 0,22583793 0,39065076 0,18778168 0,09960125 0,64627799 0,01908549 -0,034075288

210 GSM1213809 1A 78,58 0 1,27 0 1,273 55,7512198 0,49886103 0,26193068 0,17833556 0,07044145 0,89706131 0,03197377 -0,035337675

211 GSM1213810 IB 70,38 0 0,15 0 0,153 120,61426 0,1835528 0,39962366 0,15972647 0,07064749 0,3531906 0,00382419 -0,006785481

212 GSM1213811 2 62,68 0 1,37 0 1,372 98,2007571 0,78808573 0,13584634 0,06582709 0,20465383 0,82147996 0,06993276 -0,051192012

213 GSM1213812 2 62,17 1 0,8 0 0,802 25,9790407 0,68673117 0,3013052 0,07254406 0,17487878 0,95329796 0,05124043 -0,026569191

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv.

No surv. (years) Po fibro epith. vess. CD14 CD19

CD56 neutro

(years)

214 GSM1213814 IB 70,82 0 5,1 0 5,103 56,4707246 0,81179844 0,26682902 0,08630916 0,19290188 0,89852746 0,06975001 -0,032088572

215 GSM1213816 2 70,56 0 0,09 0 0,093 14,5986232 0,45796811 0,25217321 0,10521632 0,14966624 0,87486003 0,03883235 -0,025810982

216 GSM1213818 2 84,95 0 3,38 0 3,379 15,0927082 0,56720963 0,35729029 0,12769124 0,1811797 0,5619177 0,04197642 -0,027115335

217 GSM1213819 IB 75,7 1 1,52 0 1,522 -10,93603 1,11317827 0,50389319 0,05623998 0,0672387 0,66674987 0,00879987 -0,041264759

218 GSM1213820 IB 67,62 1 1,91 0 1,906 6,6599878 0,45121975 0,29396108 0,07453543 0,0829362 0,75017145 0,04131736 -0,019993759

219 GSM1213824 2 70,73 1 1,59 0 1,591 65,0324569 0,29496558 0,33999063 0,1004995 0,10408635 0,64753835 -0,0034963 -0,001733382

220 GSM1213825 1A 64,13 0 7,38 0 7,381 68,9956919 0,19860336 0,36829367 0,21279311 0,08928734 0,44306072 0,04160901 -0,028361657

221 GSM1213826 IB 71,7 1 0,57 0 0,569 -10,967654 0,45795506 0,41282058 0,0621049 0,01308334 0,8362507 0,02491293 0,007772704

222 GSM1213827 1A 61,13 0 4,17 0 4,17 75,5779022 0,39989261 0,32224524 0,15954673 0,02947499 0,60345605 -0,0025524 0,000315909

223 GSM1213831 2 76,71 0 5,13 0 5,125 -7,2613631 0,50133774 0,44177844 0,10886318 0,07856222 0,47648513 0,04583684 -0,026595586

224 GSM1213833 IB 68,95 1 0,56 1 0,126 96,2377605 0,50394795 0,26178329 0,11083862 0,09286952 0,94362794 0,03192336 -0,009107917

225 GSM1213834 IB 68,32 0 2,71 0 2,708 100,88281 0,50226534 0,23908184 0,16232651 0,22484846 0,87985781 0,02531139 0,05358512

226 GSM1213836 2 55,53 0 1,26 0 1,262 -2,6929122 0,2742576 0,16737163 0,12812134 0,09339585 0,3940503 0,03322673 -0,018806979

227 GSM1213837 IB 74,09 1 7,61 0 7,608 0,53290604 1,15033551 0,22781827 0,05691216 0,12943005 0,57226495 0,04056354 -0,011033303

228 GSM1213840 1A 65,69 1 1,23 NA 0,016 -38,411896 0,55180172 0,15121038 0,12690514 0,16140122 0,64618372 0,03307326 -0,02340574

229 GSM1213844 1A 70,62 0 4,54 0 4,539 0,24579522 1,0193591 0,24865746 0,09809734 0,2399395 0,84501434 0,02251413 -0,037694658

230 GSM1213846 IB 75,58 1 0,31 0 0,315 51,2592197 0,69487239 0,2087995 0,14844981 0,1728475 0,87239553 0,04181199 -0,031786086

231 GSM1213847 1A 76,07 0 8,26 0 8,263 74,6731524 0,38236394 0,31645709 0,2011291 0,14141537 0,80342793 0,02839072 -0,011267581

232 GSM1213848 2 76,25 1 0,1 0 0,099 117,717581 0,59581432 0,22635099 0,05908792 0,1721894 0,80811875 0,0175775 -0,025601486

233 GSM1213849 1A 60,08 0 4,16 0 4,162 127,837921 0,71486554 0,25362077 0,1370216 0,1889465 0,91757608 0,06694091 -0,005040267

GSE31210 (histology : ADC)

234 GSM773540 2 55 1 1,19644079 1 0,69267625 225,007707 0,34026708 0,19423623 0,07984936 0,0757678 0,0050361 -0,0022795 0,013635027

235 GSM773541 2 38 0 2,03422313 1 0,15605749 120,319103 0,51681586 0,23792888 0,03701746 0,21525233 0,47971496 -0,001894 0,012624598

236 GSM773542 2 30 0 7,1211499 0 7,1211499 131,524509 0,56772595 0,28970916 0,03733221 0,15595342 0,31802755 -0,0028066 0,010216885

237 GSM773543 2 64 0 3,21149897 0 3,21149897 126,576902 0,2052909 0,48168981 0,08031884 0,05773608 0,33673797 0,00274512 0,01026

238 GSM773544 2 63 0 6,48596851 0 6,48596851 100,600223 0,44017431 0,21873174 0,08988714 0,11135909 0,55654249 0,00498236 0,005821914

239 GSM773545 2 60 0 5,14442163 0 5,14442163 148,105253 0,24645286 0,27463054 0,12418182 0,20267026 0,6904269 0,01420462 -0,042593203

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv.

No surv. (years) Po fibro epith. vess. CD14 CD19

CD56 neutro

(years)

240 GSM773546 2 68 0 1,65913758 0 1,65913758 37,4404178 0,85518981 0,39455802 0,06396875 0,16239253 0,5389516 0,00343936 -0,035629266

241 GSM773547 2 58 1 0,82135524 0 0,39151266 171,532872 0,5333422 0,20284328 0,1004313 0,19365769 0,21489566 0,00729782 -0,004383281

242 GSM773548 1A 63 0 5,25393566 0 5,25393566 187,278249 0,43589443 0,19245685 0,09710181 0,09326635 0,08956199 -0,0102942 0,011468483

243 GSM773549 1A 56 0 5,02395619 0 5,02395619 218,263148 0,27107958 0,24589201 0,10014356 0,17317777 0,61174578 -0,0082169 -0,032879304

244 GSM773550 1A 34 0 5,00479124 0 5,00479124 122,795934 0,5402776 0,24920134 0,06550422 0,11787353 0,56175108 -0,0012508 0,035461627

245 GSM773551 2 75 1 5,0403833 NA 3,72073922 153,4627 0,29896872 0,26548797 0,0725143 0,22150797 0,39695774 0,03406043 0,009726717

246 GSM773552 2 60 1 1,74948665 NA 1,61533196 -1,5492092 0,88032431 0,16249964 0,06210674 0,18639269 0,58154325 0,02968081 -0,025934995

247 GSM773553 IB 46 1 3,58932238 NA 1,19917864 274,578252 0,22811658 0,3411577 0,06098352 0,05219756 0,34772403 -0,0147514 -0,042993289

248 GSM773554 IB 60 0 3,00616016 NA 2,35728953 255,407683 0,12339651 0,3704875 0,0537162 0,08246188 0,28767697 -0,0132845 -0,044593296

249 GSM773555 1A 61 0 3,25530459 NA 1,47296372 -26,143045 0,52801533 0,24302147 0,1007984 0,13246772 0,68342557 0,04577332 0,035063055

250 GSM773556 1A 63 0 10,5763176 NA 4,00273785 120,334792 0,32796553 0,230172 0,07211078 0,12522496 0,40571215 0,00729984 -0,021131944

251 GSM773557 2 47 0 4,03832991 NA 4,03832991 -3,8194702 0,68026197 0,27991897 0,08938794 0,20006515 0,78303625 0,0289215 -0,039636991

252 GSM773558 2 59 0 5,08145106 NA 5,08145106 -44,5979 0,76057418 0,19294809 0,10441365 0,0699331 0,41223022 0,01182843 0,047952277

253 GSM773559 2 64 0 8,39698836 NA 8,39698836 50,6242151 0,34848023 0,15496293 0,06816364 0,28727334 0,6069934 0,03100645 0,014627929

254 GSM773560 2 60 0 3,1266256 0 3,1266256 -11,5564 0,81232432 0,13156244 0,10458509 0,19609142 0,75180463 0,02745317 -0,019283227

255 GSM773561 IB 61 0 4,99657769 0 4,99657769 147,926206 0,44572878 0,31927543 0,12547249 0,13937642 0,59826775 0,01399752 -0,040236627

256 GSM773562 IB 53 0 4,40793977 0 4,40793977 0,81318438 0,50398335 0,2298047 0,14139872 0,21765249 0,58608528 0,02351257 0,008777231

257 GSM773563 IB 53 0 5,51403149 0 5,51403149 34,0402245 0,54945633 0,2303542 0,0741738 0,18807831 0,54831779 0,03770265 -0,011718618

258 GSM773564 IB 53 0 4,99931554 0 4,99931554 153,671068 0,22846542 0,35881996 0,12719593 0,15669881 0,34408467 0,01785258 -0,027849396

259 GSM773565 IB 67 0 5,99863107 0 5,99863107 99,6640709 0,74243311 0,26865658 0,04963785 0,24892332 0,63015661 -0,007764 0,001032633

260 GSM773566 IB 69 0 9,14989733 0 9,14989733 99,4200336 0,72771544 0,2704009 0,1144054 0,23036078 0,79634964 0,00966759 -0,052298218

261 GSM773567 1A 64 0 3,63586585 0 3,63586585 46,5705038 0,37373552 0,20529969 0,1839151 0,42188353 0,86976714 0,00086611 -0,02067191

262 GSM773568 1A 69 0 8,00821355 0 8,00821355 58,9569051 0,9428127 0,2023202 0,06897216 0,28540045 0,35712874 0,01881168 -0,011500716

263 GSM773569 1A 50 0 7,88501027 0 7,88501027 143,680117 0,13909779 0,26135075 0,10284407 0,17736823 0,75725678 0,01625189 -0,035740482

264 GSM773570 1A 70 0 4,72005476 0 4,72005476 108,964364 0,49833676 0,24388681 0,15035873 0,18377242 0,87003682 0,02035761 -0,024352834

265 GSM773571 2 57 0 7,57015743 1 4,48459959 104,780447 0,85708724 0,17836441 0,07723347 0,21696175 0,1397864 0,01427532 0,020071893

266 GSM773572 2 58 0 4,18617385 1 0,862423 6,10462927 0,81296697 0,09705632 0,11861512 0,35946772 0,80116427 0,04171194 -0,024242269

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fibro epith. vess. CD14 CD19

No surv. (years) Po CD56 neutro

(years)

267 GSM773573 2 69 1 0,60506502 1 0,27104723 98,7737532 0,66929699 0,16134139 0,06630017 0,23888039 0,33036673 -0,0209757 0,023800387

268 GSM773574 2 61 1 1,49486653 1 0,27378508 6,76816701 0,74848191 0,29078974 0,12288666 0,27182066 0,65231511 0,01772734 -0,025416105

269 GSM773575 2 68 1 0,94729637 1 0,44626968 76,3934819 0,38813116 0,21080872 0,08644171 0,22345946 0,85630537 0,01562099 -0,026696835

270 GSM773576 2 64 1 2,33538672 1 0,53661875 54,5519954 0,90258823 0,09432417 0,23270768 0,26801193 0,95983989 0,01533062 -0,057627366

271 GSM773577 2 69 1 7,28542094 1 1,97946612 113,158738 0,52651971 0,23100019 0,09139401 0,17897509 0,41438667 0,0150052 -0,021196801

272 GSM773578 2 66 0 2,23682409 1 1,85078713 214,944009 0,27921124 0,20812425 0,07891158 0,09728473 0,14278425 0,00622715 -0,005065008

273 GSM773579 2 68 1 1,16358658 1 0,6844627 26,8631237 0,44701631 0,21412149 0,16621657 0,25682178 0,6594293 0,00631967 -0,030772625

274 GSM773580 2 69 0 3,50718686 1 3,50718686 7,26266119 0,98075879 0,0753354 0,16936013 0,28435283 0,85607377 0,023335 -0,007330412

275 GSM773581 IB 64 0 2,85831622 1 0,81314168 -26,777384 0,52993961 0,14413854 0,07865398 0,20451656 0,62387948 0,01009978 -0,006288342

276 GSM773582 IB 64 0 1,54688569 1 1,4017796 87,0518945 0,45709061 0,18296565 0,05305107 0,09987476 0,62864295 0,00660219 -0,019771194

277 GSM773583 IB 66 1 2,89938398 1 1,73853525 69,6285445 0,67052932 0,23322446 0,10577172 0,32031004 0,85679184 0,0328298 0,005397411

278 GSM773584 IB 64 1 4,44900753 1 2,22587269 27,2575568 0,51832629 0,21037601 0,10875481 0,28853895 0,43764084 0,00500755 -0,007016762

279 GSM773585 IB 68 1 4,64065708 1 3,79739904 91,7808643 0,59675836 0,35176854 0,07038404 0,19022934 0,22843398 0,00955022 0,002814912

280 GSM773586 IB 68 0 8,14784394 1 3,1321013 9,11431528 0,89851598 0,23229467 0,06483476 0,21315853 0,75264104 0,00743773 -0,034641562

281 GSM773587 IB 63 1 3,12936345 1 0,7063655 115,516009 0,41176898 0,39268889 0,08170929 0,22143534 0,70655831 -0,0154946 -0,037633793

282 GSM773588 IB 58 0 4,60506502 1 0,74469541 70,5872634 0,89202259 0,08509068 0,1861176 0,2923173 0,80387119 0,0090831 -0,057088035

283 GSM773589 IB 71 1 3,40041068 1 2,88021903 90,9183603 0,45057656 0,22224485 0,0742784 0,28273226 0,71439377 0,01390272 -0,024876057

284 GSM773590 IB 52 0 6,16563997 1 2,13552361 118,728493 0,53954931 0,21945453 0,10389585 0,23239085 0,82269584 0,02809853 -0,031852869

285 GSM773591 1A 66 1 2,58179329 1 1,70294319 66,3102712 0,78951659 0,28183254 0,11241319 0,26098301 0,24201508 0,01242842 -0,004213785

286 GSM773592 1A 66 1 3,68514716 1 0,78576318 10,4204757 0,90555548 0,36397137 0,066698 0,14890994 0,44552158 0,01567358 -0,023282745

287 GSM773593 1A 47 1 4,05749487 1 3,73169062 170,728596 0,36662308 0,20782394 0,08191453 0,16061024 0,1203471 0,01359067 0,015193062

288 GSM773594 1A 64 0 6,53251198 1 0,54209446 141,572314 0,48777341 0,31972422 0,12739013 0,15844803 0,59555719 0,01784219 -0,022834697

289 GSM773595 1A 54 0 4,27104723 1 2,72963723 95,9759381 0,36261105 0,31272693 0,12539092 0,18162307 0,4750656 0,01276861 -0,024455588

290 GSM773596 1A 67 1 2,74058864 1 1,79603012 161,350619 0,57919923 0,19578447 0,17935501 0,2549007 0,39053192 0,01644531 0,00385719

291 GSM773597 2 54 1 0,70910335 0 0,70910335 115,339807 0,29594722 0,28126058 0,12244455 0,20470945 0,61637286 0,00488578 -0,017092841

292 GSM773598 2 65 0 6,26694045 0 6,26694045 142,18468 0,3223208 0,21953662 0,04852807 0,14021582 0,40604733 0,00824581 -0,03357685

293 GSM773599 2 49 0 5,24572211 0 5,24572211 -31,504681 0,62911638 0,19346479 0,13855191 0,14385856 0,96202709 0,02898509 -0,0083801

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. f epith. vess. CD14 CD19

No surv. (years) Po ibro

CD56 neutro

(years)

294 GSM773600 2 62 0 5,60711841 0 5,60711841 16,0131812 0,93981579 0,11502975 0,11096121 0,26647768 0,83506241 0,01355678 -0,044251644

295 GSM773601 2 61 0 4,03832991 0 4,03832991 45,9096067 0,39362799 0,31933986 0,08986857 0,16483018 0,18577873 -0,0015647 0,084724485

296 GSM773602 2 57 0 4,21355236 0 4,21355236 118,677562 0,52097604 0,17301636 0,21902632 0,22248996 0,63427254 0,00553444 -0,044877682

297 GSM773603 2 60 0 1,7412731 0 1,7412731 -30,634486 0,69164594 0,26747754 0,12922678 0,2677604 0,70541738 0,01002375 -0,013233148

298 GSM773604 2 46 0 3,49075975 0 0,87063655 75,5265822 0,45939871 0,14713668 0,09290215 0,28738477 0,76144292 0,05163707 0,043720762

299 GSM773605 2 52 0 5,48939083 0 5,48939083 22,7626136 0,79250942 0,11439432 0,15339036 0,19109728 0,8014571 0,03004742 0,006494486

300 GSM773606 2 54 0 5,3798768 0 5,3798768 260,86888 0,39210005 0,0775128 0,27272741 0,21292794 0,06356993 0,02141261 0,009659776

301 GSM773607 IB 58 0 6,63928816 0 6,63928816 193,889063 0,20333053 0,07397593 0,14528814 0,4833618 0,48242128 -0,0083272 -0,055133365

302 GSM773608 IB 64 0 4,28747433 0 4,28747433 82,0157246 0,47367888 0,16305316 0,21800631 0,18616037 0,58449913 0,00813175 -0,008835752

303 GSM773609 IB 65 0 2,71047228 0 2,71047228 172,298991 0,37893331 0,26024197 0,15887677 0,192814 0,32820069 0,01164206 0,005182909

304 GSM773610 IB 52 0 1,99589322 0 1,99589322 147,03683 0,52452101 0,32716944 0,09211867 0,20825714 0,30001646 0,01879502 -0,02967626

305 GSM773611 IB 61 0 6,44490075 0 6,44490075 114,755723 0,21391615 0,20720237 0,12685948 0,24686742 0,58770658 0,02086668 -0,030918456

306 GSM773612 IB 61 0 2,23956194 0 2,23956194 43,2558537 0,81082217 0,05980524 0,13463299 0,27995059 0,91985478 0,03900647 -0,023105669

307 GSM773613 IB 62 0 5,50034223 0 5,50034223 19,8623608 0,4422919 0,20870787 0,11771931 0,29972656 0,730876 0,03243609 -0,006465723

308 GSM773614 IB 47 0 6,97878166 0 6,97878166 76,7935832 0,53351612 0,27227527 0,11919325 0,20876457 0,50448024 0,01526245 -0,009529233

309 GSM773615 IB 64 0 9,33880903 0 9,33880903 279,205246 0,12472921 0,37384874 0,09758838 0,05351888 0,30978865 -0,0255953 -0,042362707

310 GSM773616 IB 50 0 4,94455852 0 4,94455852 26,8634373 0,36526855 0,12827084 0,08288076 0,21042825 0,69548114 0,01810302 0,033102692

311 GSM773617 1A 66 0 5,30321697 0 5,30321697 96,5113438 0,23481401 0,32322684 0,14411917 0,21851847 0,64528767 0,01278756 -0,017298492

312 GSM773618 1A 56 0 4,1615332 0 4,1615332 195,40347 0,25338442 0,21684094 0,15810844 0,15285011 0,40632684 -0,00556 -0,035155469

313 GSM773619 1A 76 0 3,76454483 0 3,76454483 121,231628 0,78373784 0,20411232 0,10552165 0,20090735 0,14949563 0,01496493 -0,016608588

314 GSM773620 1A 56 0 4,80766598 0 4,80766598 241,329613 0,40608078 0,25929747 0,18893064 0,14465416 0,34909355 -0,0078202 -0,035954472

315 GSM773621 1A 53 0 4,37234771 0 4,37234771 -79,680464 0,91800386 0,19470347 0,14106729 0,26145356 0,78834459 0,03522478 0,018317089

316 GSM773622 1A 57 0 4,69267625 0 4,69267625 240,228135 0,39940209 0,07472626 0,24402626 0,21170499 0,10604692 0,00462248 0,02445146

317 GSM773623 1A 61 0 4,48186174 0 4,48186174 157,785076 0,25141712 0,22233035 0,11497968 0,18131475 0,44472805 0,00559202 -0,007697413

318 GSM773624 1A 66 0 4,52566735 0 4,52566735 238,03286 0,39063382 0,20196802 0,12355709 0,10097582 0,31183673 0,00062385 -0,041467446

319 GSM773625 1A 66 0 3,27446954 0 3,27446954 56,7817696 0,73207406 0,09857776 0,22466773 0,29762789 0,60299595 0,02718341 0,013919185

320 GSM773626 1A 57 0 4,65982204 0 4,65982204 75,2786724 0,42898753 0,23457664 0,12312021 0,20707916 0,44728942 0,03083031 -0,009289538

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. f epith. vess. CD14 CD19

No surv. (years) Po ibro

CD56 neutro

(years)

321 GSM773627 1A 61 0 5,61259411 0 5,61259411 139,91488 0,42607825 0,22743413 0,09749492 0,16865096 0,32199013 0,0127363 -0,022268792

322 GSM773628 1A 63 0 3,43874059 0 3,43874059 12,948187 0,88781262 0,27375048 0,08004382 0,15745772 0,33796436 0,00882863 -0,011049842

323 GSM773629 1A 60 0 2,23956194 0 2,23956194 94,2698699 0,76330583 0,09780526 0,14325656 0,36024117 0,60323995 0,03531001 -0,021290486

324 GSM773630 1A 59 0 3,15947981 0 3,15947981 43,5188107 0,33157725 0,09095224 0,09993191 0,21180499 0,7985462 0,02567399 0,002799142

325 GSM773631 1A 55 0 8,37234771 0 8,37234771 150,730321 0,31409702 0,31405826 0,16520862 0,13250967 0,21105774 0,01016121 -0,005544249

326 GSM773632 1A 52 0 5,31416838 0 5,31416838 298,46524 0,33350585 0,12277267 0,0772799 0,093207 -0,0171582 -0,00915 -0,008126168

327 GSM773633 1A 68 0 4,36960986 0 4,36960986 92,3367377 0,49616216 0,20196798 0,07759527 0,15064136 0,81129662 0,01029408 -0,037999702

328 GSM773634 1A 55 0 6,70773443 0 6,70773443 80,2786592 0,32292892 0,32591657 0,13748474 0,23414332 0,6477364 0,0420935 -0,02258835

329 GSM773635 1A 64 0 5,14989733 0 5,14989733 85,3669487 0,37885427 0,23947033 0,18426852 0,28543594 0,76403595 0,03510402 -0,030073622

330 GSM773636 1A 51 0 4,48186174 0 4,48186174 4,33730134 0,41501217 0,24783261 0,24567025 0,12692121 0,77569199 0,0157048 -0,030761604

331 GSM773637 1A 55 0 5,5687885 0 5,5687885 124,842463 0,3409589 0,27175239 0,11251792 0,25621883 0,50460248 0,00721998 -0,005411932

332 GSM773638 1A 65 0 5,84257358 0 5,84257358 170,206036 0,52388509 0,2238038 0,17493145 0,15557438 0,67340832 -7,01E-05 -0,029044671

333 GSM773639 2 60 1 2,13278576 1 1,26214921 71,204364 0,42952602 0,2409882 0,12303395 0,14748518 0,70167853 0,01640191 -0,038670902

334 GSM773640 2 58 1 1,47843943 1 0,8569473 102,648836 0,65959464 0,21764782 0,15224337 0,23803074 0,38252544 -0,001413 -0,027070357

335 GSM773641 2 68 0 3,60574949 1 1,47843943 84,3123194 0,33537857 0,24870246 0,1395586 0,11974225 0,3121616 0,00296067 -0,019612965

336 GSM773642 2 65 0 5,42094456 1 0,93360712 228,21713 0,16887733 0,16445951 0,04511526 0,10004847 0,11241685 -0,0030058 -0,010634476

337 GSM773643 2 66 1 1,92197125 1 1,72758385 21,4718793 0,74647688 0,2081 0,09277716 0,26825287 0,74071416 0,0313962 -0,027650847

338 GSM773644 2 66 1 1,54414784 1 0,69267625 123,517848 0,37029008 0,26594043 0,08965368 0,26012353 0,59940635 0,02803454 -0,030178693

339 GSM773645 2 62 1 2,15742642 1 1,07323751 112,158259 0,59051333 0,2453926 0,07590628 0,07224962 0,17054424 0,00134545 -0,003706313

340 GSM773646 2 58 0 4,0054757 1 1,31416838 46,3736915 0,6837888 0,19470837 0,14228473 0,24620013 0,80978336 0,02461607 -0,022653477

341 GSM773647 2 49 1 3,68240931 1 1,67830253 62,5416849 0,43515944 0,24883138 0,12773439 0,21364644 0,74807925 0,02588882 -0,041333816

342 GSM773648 2 61 0 2,27789185 1 2,16290212 36,1383471 0,74441088 0,20130306 0,10339285 0,26899816 0,49723697 0,0041184 -0,024162397

343 GSM773649 2 59 0 7,35660507 1 2,2587269 40,9424299 0,66559054 0,26121962 0,07017514 0,32172676 0,55944801 0,02343058 -0,010313782

344 GSM773650 2 53 1 3,07186858 1 1,47296372 111,924465 0,31591341 0,2633341 0,10403467 0,11979922 0,65296708 -0,0052308 -0,039971748

345 GSM773651 2 64 0 7,3045859 1 4,72279261 32,8123875 0,90859978 0,23897912 0,08330912 0,10575621 0,13808912 0,00858888 0,002034025

346 GSM773652 IB 67 0 5,30047912 1 1,0513347 89,7451232 0,32410742 0,33696459 0,11824143 0,18363822 0,49301218 0,03236838 -0,035358049

347 GSM773653 IB 69 0 2,38466804 1 1,60711841 106,923732 0,43133932 0,28456326 0,14005335 0,24290335 0,4442636 0,02652413 -0,025985809

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fibro epith. vess. CD14 CD19

No surv. (years) Po CD56 neutro

(years)

348 GSM773654 IB 61 0 7,31279945 1 6,2477755 67,8423998 0,66650255 0,18927631 0,06126498 0,29735867 0,70399156 0,02910904 -0,040736764

349 GSM773655 IB 64 0 4,05749487 1 2,27789185 122,711358 0,36405016 0,26174512 0,06517909 0,06504602 0,65923995 0,00422803 -0,014080437

350 GSM773656 IB 53 0 3,08829569 1 3,08281999 39,4458548 0,55122133 0,11282229 0,21866733 0,27091913 0,92529677 0,01599527 -0,006129974

351 GSM773657 IB 71 1 2,85284052 1 2,11362081 120,904367 0,49301928 0,19591134 0,16678644 0,23880783 0,49894593 0,02057528 -0,010401126

352 GSM773658 IB 52 1 3,36481862 1 1,35523614 -12,748502 0,70479568 0,23657509 0,08121938 0,17011324 0,67074227 0,00692778 -0,021759796

353 GSM773659 IB 52 1 6,19575633 1 3,40041068 -22,672518 0,7947535 0,20249152 0,09163238 0,19578263 0,65761341 0,01364732 0,025826444

354 GSM773660 1A 54 0 4,84599589 1 2,70225873 80,1295256 0,59515479 0,23037132 0,14789203 0,14521051 0,52567484 0,00953866 -0,032210673

355 GSM773661 1A 49 1 3,92334018 1 2,2642026 44,0245116 0,6706385 0,25966464 0,1001995 0,19024135 0,74882787 0,01595842 -0,041728055

356 GSM773662 1A 68 0 4,99110198 1 2,86652977 157,098795 0,35344845 0,20191256 0,14258959 0,28757735 0,56478502 0,01815116 -0,015617785

357 GSM773663 1A 62 0 5,44284736 1 4,67077344 62,2382606 0,48999627 0,27307617 0,13660248 0,17852331 0,6198671 0,00943274 -0,020050824

358 GSM773664 1A 63 0 3,92607803 1 0,97467488 162,587558 0,20004391 0,24077144 0,10237801 0,16781153 0,08671192 0,00759639 -0,011404576

359 GSM773665 1A 63 1 1,724846 1 1,26762491 45,5839637 0,45745738 0,21021333 0,08913604 0,46127305 0,81294042 0,02877443 -0,023282103

360 GSM773666 1A 62 0 4,20807666 1 1,49760438 16,0850132 0,47558206 0,28409452 0,13602549 0,23910997 0,67306787 0,03268777 -0,036161992

361 GSM773667 1A 57 1 3,91238877 1 3,42778919 64,0297119 0,31691349 0,2005601 0,15135491 0,2563942 0,73328479 0,02614103 -0,010214232

362 GSM773668 1A 39 1 2,84188912 1 1,5523614 195,825101 0,19079761 0,22761129 0,09905041 0,12082497 0,08539528 -0,0031448 0,004648399

363 GSM773669 2 55 0 6,80629706 0 6,80629706 70,2286729 0,50341886 0,22118605 0,10905139 0,1768576 0,83348503 0,01618675 -0,013588556

364 GSM773670 2 47 0 2,02600958 0 2,02600958 29,5792414 0,93449928 0,20468427 0,10539747 0,22905684 0,70951449 0,00594485 -0,047713945

365 GSM773671 2 64 0 2,85284052 0 2,85284052 207,017859 0,55021038 0,15187838 0,11082934 0,18588202 0,15728527 0,00891106 -0,02399402

366 GSM773672 2 60 0 3,46885695 0 3,46885695 93,7279267 0,38477799 0,24470357 0,11519081 0,19621469 0,56522483 0,02068969 -0,015899869

367 GSM773673 2 48 0 2,78439425 0 2,78439425 82,6561464 0,37532775 0,22841004 0,11720583 0,15922156 0,43325254 0,00795307 -0,015743593

368 GSM773674 2 60 0 2,85010267 0 2,85010267 53,0059093 0,66754281 0,13140135 0,0688128 0,26186105 0,79001155 0,04117742 0,013351129

369 GSM773675 2 52 0 5,08966461 0 5,08966461 34,2444613 0,67232068 0,25195258 0,10601226 0,23850888 0,54621179 0,00658816 -0,021143744

370 GSM773676 2 48 0 4,7008898 0 4,7008898 123,226278 0,47932588 0,24384764 0,10685122 0,27559795 0,51237189 0,01212573 -0,028964094

371 GSM773677 2 60 0 4,09034908 0 4,09034908 61,6175006 0,50671493 0,22198587 0,09604036 0,2686736 0,90694436 0,03862813 -0,035444504

372 GSM773678 2 49 0 2,06433949 0 2,06433949 99,4983739 0,71997977 0,3042464 0,1685093 0,1723309 0,42086519 0,00728295 -0,027512729

373 GSM773679 2 63 0 6,47227926 0 1,10335387 44,9305778 0,75129113 0,13798361 0,12718287 0,28385969 0,87217212 0,03311184 -0,007285269

374 GSM773680 IB 68 0 4,74469541 0 4,74469541 82,7882522 0,39470748 0,33451259 0,10572415 0,2111507 0,80137387 0,00697676 -0,043241686

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. f epith. vess. CD14 CD19

No surv. (years) Po ibro

CD56 neutro

(years)

375 GSM773681 IB 58 0 5,31416838 0 5,31416838 124,578776 0,4493866 0,16475731 0,21310394 0,21341256 0,69369816 0,00245654 -0,0255848

376 GSM773682 IB 68 0 2,11909651 0 2,11909651 51,3767335 0,55283686 0,25829985 0,12724692 0,17422249 0,64311812 0,01421555 -0,038687616

377 GSM773683 IB 64 0 7,97535934 0 7,97535934 25,3402973 0,87380495 0,20158554 0,10283128 0,08277077 0,27694688 0,01370353 0,020472711

378 GSM773684 IB 58 0 4,93634497 0 4,93634497 164,647003 0,24836811 0,28428862 0,09786909 0,14700941 0,52975113 0,00127764 -0,022456374

379 GSM773685 IB 62 0 5,2347707 0 5,2347707 198,076744 0,27100042 0,33628596 0,14164671 0,16110814 0,10325584 0,00865086 0,018258434

380 GSM773686 IB 66 0 4,05475702 0 4,05475702 178,598725 0,38471851 0,24862174 0,13745759 0,13228911 0,22759392 0,01314018 -0,006560433

381 GSM773687 IB 68 0 3,37029432 0 3,37029432 202,090581 0,55964694 0,20751056 0,15925946 0,15646675 0,04472362 -0,0098715 0,036611124

382 GSM773688 IB 68 0 5,37713895 0 5,37713895 108,129624 0,63994592 0,20173278 0,08911044 0,2362614 0,66811356 0,00194206 -0,040247992

383 GSM773689 IB 72 0 9,17727584 0 9,17727584 170,377598 0,40943818 0,26371784 0,15774574 0,1394904 0,64234686 0,0024418 -0,034251667

384 GSM773690 IB 62 0 5,908282 0 5,908282 137,017412 0,2771136 0,31151406 0,12055204 0,1382028 0,59273432 0,01191585 -0,000882653

385 GSM773691 IB 67 0 9,48939083 0 9,48939083 213,996875 0,28563155 0,27067956 0,09143383 0,10189071 0,40318909 -0,0061362 -0,009180594

386 GSM773692 IB 52 0 8,93360712 0 8,93360712 70,8103881 0,67350656 0,29702415 0,13064264 0,22675953 0,42211887 0,01365178 0,02318194

387 GSM773693 IB 67 0 4,99110198 0 4,99110198 66,1997896 0,30790972 0,2779577 0,15895626 0,23707635 0,49994379 0,01355109 -0,002008622

388 GSM773694 IB 59 0 5,08145106 0 5,08145106 100,704353 0,30854077 0,22759553 0,11094379 0,19781727 0,95450054 0,04221224 -0,042108725

389 GSM773695 IB 70 0 6,70499658 0 6,70499658 130,166247 0,64014694 0,1371298 0,22743377 0,27729436 0,46215322 0,00414365 0,015087979

390 GSM773696 IB 59 0 5,08966461 0 5,08966461 102,845699 0,25609926 0,33863426 0,15840504 0,13843771 0,49305627 0,01625528 -0,022977727

391 GSM773697 IB 56 0 5,47022587 0 5,47022587 -8,7399783 0,74802316 0,37361192 0,08850494 0,1031055 0,31348212 0,03013265 0,039325749

392 GSM773698 1A 69 0 5,07049966 0 5,07049966 78,0528937 0,34443511 0,27159941 0,10289857 0,13392726 0,54623099 0,01875254 -0,028282578

393 GSM773699 1A 61 0 5,18548939 0 5,18548939 197,977808 0,21767616 0,2816697 0,1077745 0,12915357 0,30907644 0,00854214 -0,012707505

394 GSM773700 1A 54 0 5,09514031 0 5,09514031 75,8575045 0,44502878 0,17035685 0,18158848 0,20160902 0,73914634 0,04458548 -0,003672817

395 GSM773701 1A 64 0 4,56947296 0 4,56947296 114,350593 0,65363888 0,11948891 0,19689042 0,20788355 0,32281075 0,02675517 -0,032715634

396 GSM773702 1A 45 0 8,73100616 0 8,73100616 225,489432 0,20543783 0,21820792 0,07184841 0,13108109 0,01493412 -0,0007838 -0,013346941

397 GSM773703 1A 55 0 4,98836413 0 4,98836413 81,6735073 0,37463832 0,22696828 0,09611854 0,13764979 0,30706632 0,01466257 -0,01451881

398 GSM773704 1A 61 0 4,95277207 0 4,95277207 91,8605939 0,29209908 0,2766756 0,13003773 0,17846302 0,61264713 0,03113559 -0,039784593

399 GSM773705 1A 65 0 6,98699521 0 6,98699521 250,724381 0,32243211 0,12679024 0,19506231 0,20851823 0,04802642 0,00271399 -0,001803043

400 GSM773706 1A 65 0 8,12594114 0 8,12594114 205,027083 0,27066423 0,24691729 0,08478326 0,20594449 0,16889182 -0,0054883 -0,03639703

401 GSM773707 1A 47 0 8,39425051 0 8,39425051 189,87815 0,40857202 0,25860975 0,17245229 0,20823726 0,19004803 0,00238256 0,003931593

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv.

No surv. (years) Po fibro epith. vess. CD14 CD19

CD56 neutro

(years)

402 GSM773708 1A 60 0 3,86584531 0 3,86584531 243,769138 0,15177132 0,17505025 0,11676704 0,05554723 0,23763698 -0,0085705 -0,028735209

403 GSM773709 1A 55 0 3,60574949 0 3,60574949 107,211624 0,5360538 0,15442438 0,11638171 0,20761748 0,39353104 0,03957723 -0,001710013

404 GSM773710 1A 61 0 3,23066393 0 3,23066393 169,697888 0,25157144 0,27893164 0,14810361 0,14891516 0,49373557 0,00428675 -0,028198035

405 GSM773711 1A 67 0 4,62149213 0 4,62149213 105,372233 0,4489676 0,20564631 0,18907361 0,25626447 0,68752701 0,01019656 -0,023291643

406 GSM773712 1A 69 0 3,87953457 0 3,87953457 194,161222 0,30070401 0,21455276 0,11266703 0,12219167 0,08314225 -2,09E-05 0,044715538

407 GSM773713 1A 65 0 3,90417522 0 3,90417522 97,8690592 0,48998708 0,2634249 0,11504394 0,19655182 0,50816244 0,01730124 -0,036389944

408 GSM773714 1A 65 0 4,58316222 0 4,07665982 141,62274 0,11376764 0,33160402 0,11781462 0,13263358 0,25955067 -0,0021143 0,004669465

409 GSM773715 1A 56 0 5,05954825 0 5,05954825 182,251683 0,07380103 0,2854317 0,15602986 0,11115792 0,12917059 0,00515523 0,017338769

410 GSM773716 1A 65 0 5,08145106 0 5,08145106 52,9915484 0,70321854 0,23118123 0,11876546 0,22933372 0,77796934 0,0040951 -0,045419047

411 GSM773717 1A 56 0 4,8733744 0 4,8733744 30,4848447 0,38298498 0,21040598 0,09925614 0,16853646 0,82978079 0,02947307 -0,023122586

412 GSM773718 1A 59 0 5,70568104 0 5,70568104 87,8824791 0,52926626 0,28986665 0,11045401 0,25209803 0,62314325 0,03887923 -0,034852533

413 GSM773719 1A 56 0 5,14442163 0 5,14442163 147,762166 0,74828313 0,15640308 0,13690387 0,16394902 0,41413401 0,00807458 -0,023071754

414 GSM773720 1A 63 0 3,04996578 0 3,04996578 196,889517 0,40338272 0,23072447 0,10517784 0,1396935 0,12137963 0,00173714 0,013007604

415 GSM773721 1A 49 0 7,68240931 0 7,68240931 207,741452 0,36299323 0,21375208 0,18653835 0,16807248 0,04223125 0,03032118 -0,024099485

416 GSM773722 1A 58 0 4,55304586 0 4,55304586 153,011491 0,44448996 0,28032427 0,1071771 0,14046925 0,21777718 0,01184971 -0,023798582

417 GSM773723 1A 62 0 4,72553046 0 4,72553046 23,8059005 0,87480422 0,14814442 0,08898196 0,31128476 0,8206038 0,0229703 -0,035282554

418 GSM773724 1A 68 0 4,45995893 0 4,45995893 103,782433 0,56638434 0,24518746 0,11709073 0,18191319 0,41999174 0,02663224 -0,022537846

419 GSM773725 1A 66 0 5,96577687 0 5,96577687 154,253047 0,32617479 0,20538772 0,10424693 0,21519267 0,48222418 0,02674268 -0,034897819

420 GSM773726 1A 57 0 5,24845996 0 5,24845996 73,6888305 0,43676764 0,2733504 0,11021271 0,19438079 0,57228654 0,02399733 -0,029314044

421 GSM773727 1A 57 0 3,95893224 0 3,95893224 88,340446 0,37405414 0,27638784 0,07140515 0,19852339 0,62956309 0,00899445 -0,003372486

422 GSM773728 1A 52 0 3,18138261 0 3,18138261 29,4053751 0,78723464 0,21688095 0,22112538 0,19729809 0,62011422 0,01949183 -0,033217427

423 GSM773729 1A 65 0 3,37029432 0 3,37029432 93,5515638 0,3522083 0,30741697 0,26027589 0,13832161 0,50516724 0,00707435 -0,029079319

424 GSM773730 1A 65 0 2,57631759 0 2,57631759 53,6892643 0,57999894 0,24763685 0,0925712 0,18361269 0,61805159 0,01255507 -0,016126216

425 GSM773731 1A 50 0 4,44353183 0 4,44353183 243,345683 0,24757634 0,20584368 0,14449845 0,11687139 0,07156998 0,02755549 -0,028281808

426 GSM773732 1A 53 0 5,07871321 0 5,07871321 250,073364 0,16657512 0,26035166 0,05051907 0,14819278 0,20844149 0,00173022 -0,02279563

427 GSM773733 1A 53 0 3,84394251 0 3,84394251 166,395412 0,19616854 0,22372558 0,10501002 0,15075371 0,45901282 0,01714697 -0,024599332

428 GSM773734 1A 66 0 6,0807666 0 6,0807666 159,185855 0,35645953 0,12557664 0,18740671 0,19203498 0,42149985 0,05939466 -0,034721892

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv.

No surv. (years) Po fibro epith. vess. CD14 CD19

CD56 neutro

(years)

429 GSM773735 1A 62 0 2,32443532 0 2,32443532 140,899977 0,23252023 0,25471468 0,16129542 0,10964688 0,52879575 0,0044303 0,020962237

430 GSM773736 1A 66 0 2,275154 0 2,275154 83,4106159 0,34144786 0,25383888 0,19661453 0,20124465 0,36807577 0,00885983 -0,010141832

431 GSM773737 1A 35 0 8,81314168 0 8,81314168 171,17636 0,24896333 0,17831936 0,12018952 0,17847981 0,2781594 0,01048683 0,002608639

432 GSM773738 1A 59 0 7,07734428 0 7,07734428 239,989727 0,12049043 0,20168278 0,12465966 0,06488964 0,22669937 -0,00445 -0,031036085

433 GSM773739 1A 67 0 6,68583162 0 6,68583162 78,7026998 0,35418128 0,20933466 0,1086276 0,13235195 0,70641859 -0,000115 -0,01977372

434 GSM773740 1A 56 0 5,229295 0 5,229295 158,564394 0,41223004 0,22100445 0,06011428 0,10584282 0,44511922 0,00306124 -0,022708438

435 GSM773741 1A 62 0 5,02121834 0 5,02121834 45,131308 0,63636542 0,3169024 0,06811253 0,12830833 0,45770116 0,02315265 -0,035524123

436 GSM773742 1A 46 0 7,9890486 0 7,9890486 39,9877238 0,32634135 0,32957387 0,08377671 0,12615958 0,44194956 0,01758469 -0,006590448

437 GSM773743 1A 67 0 6,25598905 0 6,25598905 173,195207 0,32152773 0,25014066 0,14527165 0,16165385 0,58734755 -0,0104993 -0,0417979

438 GSM773744 1A 62 0 5,88364134 0 5,88364134 131,217813 0,27906155 0,22464271 0,153802 0,13299253 0,5988732 -0,0026486 -0,034497946

439 GSM773745 1A 63 0 7,01163587 0 7,01163587 101,399426 0,66354907 0,16821328 0,08404254 0,31432421 0,43797224 0,00637825 -0,025910246

440 GSM773746 1A 52 0 5,33059548 0 5,33059548 97,9036924 0,30057161 0,26945728 0,11958434 0,33644853 0,71874769 0,01946612 -0,028636339

441 GSM773747 1A 60 0 5,0403833 0 5,0403833 263,78027 0,15337756 0,20994862 0,10705893 0,07432855 0,2356569 -0,0173236 0,018288831

442 GSM773748 1A 47 0 5,3963039 0 5,3963039 205,989151 0,3001627 0,18700427 0,08317819 0,14376975 0,56392377 0,01819245 -0,042501407

443 GSM773749 1A 56 0 6,59548255 0 6,59548255 -6,7125381 0,65061098 0,21794711 0,12805305 0,25542496 0,8194168 0,0167723 -0,042693159

444 GSM773750 1A 56 0 4,44626968 0 4,44626968 167,378029 0,41299193 0,27843337 0,09482763 0,23779664 0,29706721 0,00980574 -0,016468002

445 GSM773751 1A 63 0 6,65297741 0 6,65297741 199,472726 0,36432485 0,18354312 0,05483636 0,11724532 0,37333654 -0,0013621 0,009161363

446 GSM773752 1A 59 0 5,08145106 0 5,08145106 161,958017 0,22966123 0,30148816 0,1660959 0,08328615 0,14792821 0,00212298 -0,014616921

447 GSM773753 1A 62 0 4,15058179 0 4,15058179 86,514673 0,3599054 0,23144018 0,15756271 0,20101529 0,62634363 0,01880473 -0,032905637

448 GSM773754 1A 50 0 4,98015058 0 4,98015058 119,328515 0,27865633 0,24667139 0,12690663 0,18784875 0,50907883 0,03531031 -0,025090831

449 GSM773755 1A 55 0 6,60643395 0 6,60643395 98,4498617 0,3193737 0,30554657 0,08960035 0,16204483 0,43898538 0,00462073 -0,023084509

450 GSM773756 1A 54 0 5,06228611 0 5,06228611 80,1071133 0,54029143 0,18153259 0,09061134 0,23747019 0,94162818 0,02651834 -0,032422835

451 GSM773757 1A 65 0 5,97125257 0 5,97125257 100,544317 0,35170125 0,30633954 0,13778793 0,17132959 0,57088039 0,003398 -0,007283853

452 GSM773758 1A 66 0 5,93566051 0 5,93566051 120,900567 0,41843634 0,27544313 0,14416661 0,20775675 0,48636609 0,01768343 -0,016437176

453 GSM773759 1A 62 0 5,8973306 0 5,8973306 207,601566 0,29629475 0,26122496 0,10904948 0,10192713 0,26201783 -0,004292 -0,024996039

454 GSM773760 1A 64 0 5,67556468 0 5,67556468 186,498091 0,36173278 0,25653092 0,11429465 0,13956919 0,0963077 0,01483911 -0,016585551

455 GSM773761 1A 64 0 5,45927447 0 5,45927447 86,4105171 0,44349479 0,26830149 0,18812122 0,21935318 0,60047244 0,01589264 -0,030235004

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. Po fibro epith. vess. CD14 CD19

No surv. (years) CD56 neutro

(years)

456 GSM773762 1A 61 0 5,85078713 0 5,85078713 90,2012893 0,35695161 0,32558929 0,18886135 0,13884632 0,65327162 0,00505042 -0,025010485

457 GSM773763 1A 58 0 5,47022587 0 5,47022587 183,113473 0,29888617 0,2879473 0,16548539 0,20351446 0,29862199 0,01743293 0,007281065

458 GSM773764 1A 49 0 5,2238193 0 5,2238193 80,4382375 0,33669378 0,2431888 0,10714053 0,16889037 0,85058244 0,01870833 -0,038667782

459 GSM773765 1A 58 0 4,54483231 0 4,54483231 265,394772 0,51509159 0,18494284 0,07249762 0,12399431 0,16583042 0,01420333 -0,032872661

GSE 10245 (histology : ADC)

460 GSM258552 IB 52 0 5,05 0 5,05 125,005569 0,52288211 0,16268317 0,09804777 0,10601089 1,05154285 0,00192467 -0,009260129

461 GSM258554 2 54 1 1,866666667 0 1,866666667 5,8320536 0,58940109 0,27219822 0,11536935 0,23236579 0,93000036 0,00909467 -0,031396314

462 GSM258558 2 83 0 3,966666667 0 3,966666667 186,957443 0,44660435 0,16177101 0,05409036 0,12748294 1,01160368 -0,0027986 -0,043239076

463 GSM258559 IB 71 1 2,6 1 2,6 62,5735294 0,47976275 0,32700238 0,07422063 0,25380503 0,47266327 0,03775888 0,015782675

464 GSM258560 IB 62 1 2,8 1 0,216666667 60,6330493 0,54517178 0,27111629 0,13140093 0,09233373 0,5124941 0,00221969 0,016381682

465 GSM258561 2 62 1 1,225 0 1,225 36,5855366 0,42114867 0,3139104 0,08559789 0,0932583 0,51791838 0,07300706 0,041787077

466 GSM258564 IB 74 1 2,7 1 0,733333333 68,7462441 0,58379211 0,21633187 0,12990855 0,10486098 0,82682038 -0,013284 -0,021606929

467 GSM258567 2 57 0 3,683333333 0 3,683333333 57,2898755 0,77922028 0,16680432 0,10370921 0,22556389 0,70187038 0,01023884 -0,018249396

468 GSM258568 IB 54 1 3,416666667 1 3,416666667 149,634835 0,19980988 0,33492243 0,12449274 0,1349485 0,2232312 -0,0060365 -0,019013453

469 GSM258569 2 68 0 4,875 0 4,875 101,692638 0,29552851 0,26426547 0,06258212 0,07376979 0,82184584 0,00091504 -0,007450043

470 GSM258571 1A 59 0 4,866666667 0 4,866666667 11,4691525 0,49913772 0,26133853 0,05182729 0,05052455 0,62099257 0,05157329 0,071233434

471 GSM258572 IB 53 0 3,05 0 3,05 7,64713383 0,66657364 0,30294202 0,11410745 0,33674507 0,76598203 0,02663907 -0,023445547

472 GSM258573 IB 72 0 3,283333333 0 3,283333333 20,821583 0,38806177 0,32648144 0,19533084 0,13990481 0,88946827 0,02106187 -0,037475856

473 GSM258574 2 71 0 2,683333333 0 2,683333333 103,743194 0,60936201 0,19440472 0,09430714 0,1978291 0,92687155 0,00172952 -0,035934752

474 GSM258575 IB 70 0 4,191666667 0 4,191666667 102,534046 0,52436486 0,31306807 0,11185966 0,14844984 0,60205312 0,00443759 -0,001793216

475 GSM258576 IB 76 0 3,908333333 1 3,5 104,690647 0,12450572 0,28675741 0,18698284 0,29401982 0,65013691 0,01535573 -0,034424589

476 GSM258577 IB 57 1 1,825 1 1,508333333 87,3197589 0,72449397 0,10506908 0,11625586 0,28868207 0,95576171 -0,0091903 -0,029541039

477 GSM258579 2 77 0 3,066666667 0 3,066666667 132,104279 0,5633268 0,14502975 0,11734766 0,45648553 0,88293682 0,04159113 -0,02604668

478 GSM258581 IB 72 0 3,4 1 3,4 73,6549823 0,34108687 0,35164376 0,23160488 0,27352453 0,82815769 0,02042924 -0,050631879

479 GSM258582 IB 67 0 3,308333333 0 3,308333333 7,39347945 0,46677977 0,19330107 0,05633852 0,08669544 0,66656297 0,01205703 0,01644652

480 GSM258586 2 60 0 3,025 0 3,025 21,2858461 0,96712442 0,17398392 0,14921645 0,1440919 0,85773372 0,01227821 -0,031610552

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. vess. CD14 CD19

No surv. (years) Po fibro epith.

CD56 neutro

(years)

481 GSM258587 IB 79 1 2,908333333 1 1,666666667 64,181372 0,26347107 0,25408448 0,10775708 0,18772885 0,68859724 0,01839529 -0,0251749

482 GSM258588 1A 60 1 0,683333333 1 0,533333333 110,494 0,38636178 0,13517733 0,05723238 0,2834305 0,73902267 0,04165785 -0,038776734

483 GSM258589 IB 58 1 1,225 1 0,433333333 108,603283 0,48895512 0,2781855 0,0713783 0,11519226 0,70546438 -0,0129743 -0,027832332

484 GSM258591 3 66 1 1,241666667 1 1,241666667 64,5085766 0,49295168 0,25104304 0,12242903 0,21273929 0,6814322 0,00630013 -0,021607308

485 GSM258592 2 55 1 0,358333333 1 0,291666667 92,3047709 0,49883872 0,27790325 0,04567796 0,11007838 0,37399537 0,01441197 0,022053953

486 GSM258593 IB 71 1 1,816666667 1 0,616666667 -47,684221 0,50031419 0,53027253 0,0793746 0,08372024 0,97851954 -0,0015303 -0,03402458

487 GSM258595 2 56 1 0,791666667 1 0,266666667 -21,861676 0,63246568 0,33054493 0,14111338 0,10777843 0,72205071 0,00152138 -0,005882165

488 GSM258597 3 77 1 0,55 1 0,55 128,736852 0,19818349 0,19487475 0,21521332 0,17480956 0,7659316 0,00470943 -0,038334978

489 GSM258598 IB 72 1 1,308333333 1 0,916666667 161,587654 0,26070623 0,33162098 0,18454037 0,08051735 0,55556235 -0,0116792 -0,006251499

490 GSM258600 IB 64 0 2,333333333 1 2,05 149,896944 0,47277575 0,303853 0,05681282 0,14963844 0,96423741 -0,0014173 -0,052724655

491 GSM258601 3 48 1 1,708333333 1 0,5 60,088576 0,48452107 0,22480377 0,0422336 0,09288787 0,71747489 0,0072765 -0,01472479

492 GSM258602 1A 57 0 1,783333333 0 1,783333333 57,0960101 0,44119773 0,17541324 0,08685493 0,09566835 0,52500481 0,02670021 0,029648418

493 GSM258604 2 60 0 1,991666667 0 1,991666667 4,03278972 0,68343309 0,37718315 0,09770185 0,1018402 0,7382428 0,0062856 -0,031372273

494 GSM258605 IB 66 0 1,866666667 0 1,866666667 -56,185136 0,67581905 0,35699808 0,05409747 0,11952767 0,48611547 0,02254399 7,25E-05

495 GSM258606 3 78 0 0,658333333 0 0,658333333 79,200794 0,44219907 0,24681134 0,09814511 0,16663619 0,78033403 0,01719504 -0,035898231

496 GSM258607 IB 74 0 1,9 0 1,9 30,5885111 0,47004156 0,20497984 0,0690793 0,17180587 0,84974635 -0,0003314 -0,01209774

497 GSM258608 2 70 0 2,033333333 0 2,033333333 49,504856 0,81773283 0,18585198 0,12132303 0,17999166 0,95088384 0,01508108 -0,043897355

GSE50081 (histology : ADSQ)

498 GSM1213669 1A 63,57 1 4,11 0 4,115 -110,71582 1,08394856 0,39479295 0,06335652 0,14859868 0,72916984 0,0338504 -0,031625108

499 GSM 1213745 2 63,21 1 4,76 1 4,758 25,6942004 0,66397258 0,22544445 0,09844233 0,21013752 0,35261049 0,07640718 0,005440242

GSE31210 (healthy)

500 GSM773766 NA 30 NA 0 NA NA 256,442475 0,24851735 0,09565289 0,20218052 0,22812282 0,09232722 0,02363624 -0,010694676

501 GSM773767 NA 64 NA 0 NA NA 273,437967 0,30582506 0,09174471 0,23416707 0,23221812 0,12336642 0,02384654 -0,008781264

502 GSM773768 NA 49 NA 0 NA NA 216,335092 0,21999512 0,12923223 0,1752537 0,1570067 0,23384154 0,00907984 -0,007067856

503 GSM773769 NA 48 NA 0 NA NA 176,289296 0,2792104 0,0791613 0,20003382 0,30298165 0,34909802 0,04969014 -0,015868006

504 GSM773770 NA 38 NA 0 NA NA 257,602061 0,31175732 0,10491174 0,23073306 0,23355669 0,09063131 0,03252656 -0,01923625

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. epith. vess CD14 CD19

No surv. (years) Po fibro .

CD56 neutro

(years)

505 GSM773771 NA 59 NA 0 NA NA 174,829482 0,46938635 0,05073434 0,24159045 0,27517236 0,18541687 0,00349382 0,080319174

506 GSM773772 NA 57 NA 0 NA NA 146,754272 0,4421143 0,07337163 0,23159161 0,28513912 0,34910514 0,01457475 0,014132015

507 GSM773773 NA 68 NA 0 NA NA 177,605062 0,39752645 0,09183992 0,22108848 0,29220272 0,28244669 0,00502318 0,013696578

508 GSM773774 NA 59 NA 0 NA NA 112,578073 0,4686374 0,11957183 0,19860556 0,32582476 0,4635285 0,01338659 0,024668657

509 GSM773775 NA 61 NA 0 NA NA 218,600319 0,3509779 0,16401094 0,19925143 0,18827053 0,08646862 0,02377603 0,042354625

510 GSM773776 NA 54 NA 0 NA NA 149,514754 0,35001552 0,13073905 0,21709584 0,29662409 0,49534902 0,01742956 -0,027922595

511 GSM773777 NA 56 NA 0 NA NA 151,464632 0,62293749 0,04746548 0,26139889 0,24979902 0,54961849 -0,0087185 -0,039113188

512 GSM773778 NA 62 NA 0 NA NA 190,667903 0,37026491 0,12016955 0,21098865 0,27720525 0,37218565 0,02168387 -0,02868924

513 GSM773779 NA 64 NA 0 NA NA 226,723272 0,31392396 0,0726572 0,23064759 0,27918776 0,19392804 0,02747021 -0,012889633

514 GSM773780 NA 39 NA 0 NA NA 216,113364 0,44663027 0,07380381 0,2299928 0,27135224 0,12085491 0,00230052 0,028774253

515 GSM773781 NA 67 NA 0 NA NA 94,0962381 0,62337109 0,12480715 0,20324833 0,23019813 0,54432024 0,00415851 0,047662035

516 GSM773782 NA 89 NA 0 NA NA 119,581847 0,40207104 0,12374072 0,20638854 0,28280817 0,56094538 0,00718195 0,021007657

517 GSM773783 NA 75 NA 0 NA NA 149,624029 0,38627063 0,08056987 0,19455636 0,24775415 0,38500993 0,02145568 0,071429498

518 GSM773784 NA 70 NA 0 NA NA 105,533129 0,32816558 0,25886583 0,15612144 0,17957063 0,46682965 0,00485372 -0,013036239

519 GSM773785 NA 74 NA 0 NA NA 193,756509 0,40877202 0,11696591 0,18097511 0,18282959 0,27091646 0,00910103 -0,025435019

GSE50081 (histology : LCC)

520 GSM1213713 IB 70,52 0 4,94 0 4,945 117,75173 0,38592771 0,32100975 0,00704114 0,08020116 0,5014028 -0,0048807 -0,03108143

521 GSM1213725 IB 71,92 0 6,43 0 6,434 -71,305411 0,6612227 0,2821165 0,05212528 0,23976914 0,63402136 0,16087006 0,000884442

522 GSM1213755 1A 71,5 0 5,32 0 5,322 45,4405735 0,43171373 0,29414972 0,04558292 0,09471622 0,4775824 0,00734854 -0,014169096

523 GSM1213799 1A 54,73 1 0,19 0 0,194 100,986544 0,3678065 0,18185225 0,06472889 0,15522638 0,95891621 0,04905783 -0,034152931

524 GSM1213823 1A 73,55 1 4,04 1 3,647 -174,30783 0,41913789 0,08868961 0,10218658 0,1120317 0,76288794 0,06344188 0,016852535

525 GSM1213832 2 68,7 1 1,67 0 1,667 111,602785 0,45795304 0,11445001 0,0774374 0,21883833 0,49102044 0,06251195 -0,024480114

526 GSM1213842 IB 67 1 1,05 1 0,745 121,831697 0,70498413 0,24655148 0,14169001 0,2002086 0,88993846 0,0671698 -0,003434441

GSE37745 (histology : LCC)

527 GSM1019148 IB 65 1 0,69267625 1 0,67123288 96,2997402 0,40039248 0,18178863 0,07161194 0,1996429 0,48646237 0,02605867 0,020516487

528 GSM1019155 IB 64 1 0,42436687 1 0,26027397 50,654238 0,46962637 0,2623106 0,05633719 0,15641088 0,85678689 0,00639762 0,005231066

529 GSM1019161 IB 64 1 0,82135524 1 0,72876712 57,6061872 0,23414982 0,07750197 0,04673991 0,09675863 0,48498945 -0,0038022 0,008392711

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. pith. vess. CD14 CD19

No surv. (years) Po fibro e

CD56 neutro

(years)

530 GSM1019167 IB 61 1 0,76933607 1 0,67123288 44,6758686 0,41741893 0,21008624 0,08577279 0,18448279 0,95056794 0,03199559 -0,006000471

531 GSM1019173 3 44 0 12,1533196 0 5,32054795 6,84417427 0,56467982 0,19764046 0,0741988 0,28415738 0,69951221 0,08465415 0,040490606

532 GSM1019178 IB 56 0 11,7180014 0 12,1178082 -60,39105 0,53341247 0,40777568 0,06151772 0,23084627 0,6872541 -0,0002482 -0,022626721

533 GSM1019179 IB 66 1 0,76112252 1 0,38082192 58,1498343 0,68430471 0,26240351 0,02324315 0,0864236 0,52642067 0,00481439 -0,007259284

534 GSM1019182 IB 61 0 10,8774812 0 11,5260274 92,8059265 0,43009766 0,05781744 0,05182731 0,066208 0,92066445 -0,0044366 -0,00273564

535 GSM1019189 IB 68 1 8,21355236 0 8,33972603 88,4247911 0,44704477 0,06529026 0,06439964 0,09309782 0,59450288 0,00405585 -0,026826649

536 GSM 1019208 2 69 0 12,6543463 0 13,4630137 -14,666303 0,57253754 0,11710917 0,12614639 0,12056656 0,43221794 0,03575812 0,00500195

537 GSM1019219 IB 69 1 0,20807666 1 0,14794521 -29,153534 0,45616496 0,30050687 0,05229691 0,03472188 0,31297614 0,01305359 0,046697324

538 GSM 1019222 1A 73 1 8,04928131 1 7,8109589 -23,118922 0,79788078 0,31298235 0,07578258 0,11470476 0,81371201 0,01849582 0,004106485

539 GSM 1019223 IB 61 1 1,05954825 NA NA 9,98514654 0,36212982 0,25702527 0,13015415 0,08520197 0,85166331 0,03177911 0,010226135

540 GSM1019231 1A 57 1 5,50855578 NA NA 93,7668993 0,23141206 0,0862405 0,03859653 0,13650991 0,65094247 0,02640161 -0,028980595

541 GSM1019237 1A 48 0 13,9575633 0 6,04931507 28,3470107 0,52406334 0,33566043 0,13597716 0,17027854 0,75432206 0,01824549 -0,006543494

542 GSM 1019248 IB 64 0 7,90691307 NA NA 98,6786123 0,24526906 0,13868773 0,05321374 0,12888955 0,82454788 0,00620324 -0,038019865

543 GSM1019262 IB 56 0 6,52977413 NA NA 184,589903 0,68966036 0,46427106 0,02983303 0,0183007 0,21830268 -0,011269 -0,028544177

544 GSM1019287 IB 59 0 4,94455852 NA NA -45,415024 0,4806855 0,28424311 0,08641465 0,14277878 0,64734799 0,023037 -0,015559263

545 GSM1019301 3 52 1 0,48733744 NA NA 45,0502185 0,68274058 0,28751639 0,06879903 0,13449403 0,75365009 0,00903941 0,002814283

546 GSM1019304 IB 75 1 3,59206023 NA NA 148,803882 0,50106314 0,20035994 0,02207937 0,06945864 0,98006364 8,98E-05 0,011521459

547 GSM1019315 1A 68 1 10,5598905 NA NA 124,0722 0,54300699 0,25746679 0,07857494 0,05750648 0,72995996 -0,0008535 -0,012751917

548 GSM1019317 3 52 1 3,36481862 NA NA 66,3310186 0,21414032 0,15513783 0,12255699 0,12304741 0,80622762 0,02634412 -0,03004688

549 GSM1019327 IB 39 1 2,49691992 NA NA -22,069549 0,50543171 0,23711175 0,06923945 0,08444632 0,42160715 0,01431223 0,013720526

550 GSM1019333 IB 70 1 2,69678303 NA NA 250,260039 0,14522551 0,12773984 0,01088487 -0,0182345 0,12204319 -0,0007541 0,006674719

GSE50081 (histology : LCC for patient 551, SCC for others)

551 GSM1213721 IB 57,41 0 6,11 0 6,111 -81,599653 0,78477075 0,14794801 0,05418075 0,15969018 0,77045614 0,07552651 -0,011560576

552 GSM1213674 IB 57,31 0 7,03 0 7,034 99,2130308 0,82782118 0,23859578 0,06670191 0,15990318 0,97235236 0,02577823 -0,039704709

553 GSM1213675 2 63,63 0 6,85 0 6,85 88,9759254 0,65361519 0,45954978 -0,0099089 0,0059334 0,38503779 0,00606349 -0,014127212

554 GSM1213684 2 73,26 0 3,47 0 3,466 77,2138412 0,75352032 0,07732911 0,07997238 0,08100001 0,87027108 0,01089971 -0,036988088

555 GSM1213701 1A 73,66 1 5,22 1 5,194 -27,627992 0,57162639 0,37233449 0,0951479 0,12252278 0,74604751 0,0429424 -0,024991244

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. epith. vess. CD14 CD19

No surv. (years) Po fibro

CD56 neutro

(years)

556 GSM1213705 2 59,11 1 0,48 1 0,287 126,956828 0,61000325 0,26506002 -0,0031339 0,05914436 0,38869712 -0,00338 -0,029743477

557 GSM1213706 2 49,53 0 7,5 0 7,499 79,5187105 0,84186239 0,14056082 0,02932768 0,11396051 1,01200366 0,10455683 -0,028406776

558 GSM1213708 2 63,1 0 6,11 1 5,227 105,138574 0,87826995 0,43404524 0,01097649 0,09183587 0,52533428 -0,0108367 -0,040469032

559 GSM1213709 IB 77,27 0 5,2 1 4,679 112,199127 0,43901639 0,23540483 0,04688392 0,08950764 0,84066911 0,03577436 -0,039823299

560 GSM1213711 2 70,85 0 4,62 0 4,624 69,0270904 0,8245066 0,30337159 0,05090543 0,10782777 0,84534122 0,0215207 -0,02949289

561 GSM1213712 IB 69,07 0 6,58 0 6,582 134,294312 0,53242124 0,24760207 0,01118356 0,058473 0,87860996 0,00779014 -0,037952592

562 GSM1213714 2 62,91 0 6,15 0 6,149 -16,298902 0,67846642 0,5089129 0,02672778 0,10192009 0,76906657 0,02168691 -0,035560606

563 GSM1213718 IB 81,17 0 4,95 0 4,947 7,96854861 0,61564291 0,24204965 0,04819328 0,04855935 0,84945539 0,01962212 0,002226276

564 GSM1213719 IB 72,55 1 0,93 1 0,808 -60,082203 0,81520066 0,25818952 0,08067567 0,08001711 0,82583922 0,03133787 -0,010711475

565 GSM1213729 IB 69,7 1 2,42 1 1,933 91,0881872 0,70181552 0,22208071 -0,0054463 0,0968186 0,75460707 0,02055244 -0,043386348

566 GSM1213731 2 69,17 0 5,81 0 5,81 118,825489 0,84847068 0,41586133 0,07402581 0,13518992 0,78095373 0,02276369 -0,04827756

567 GSM1213732 1A 74,13 0 7,56 0 7,556 39,8452041 0,53623247 0,22702131 0,01881847 0,08911411 0,75263868 0,05585549 -0,013630884

568 GSM 1213744 1A 71,47 0 5,04 0 5,043 42,327315 0,5859481 0,08624473 0,04607113 0,13389716 0,90046433 0,03432663 -0,037773825

569 GSM1213748 1A 60,7 0 5,08 0 5,079 38,6698219 0,56732309 0,47441008 0,07432266 0,13404858 0,76901014 0,00539439 -0,034638989

570 GSM1213765 IB 73,23 1 2,7 0 2,7 248,434273 0,07282822 0,11632283 0,02967269 0,02367562 0,05363398 0,00978257 -0,022145683

571 GSM1213766 IB 87,11 1 3,48 0 3,48 72,5850159 0,47977093 0,37010616 0,02346795 0,09685507 0,82983978 0,03409331 -0,052187512

572 GSM1213767 IB 73,25 1 3,64 0 3,641 49,6291518 0,73582241 0,55214708 0,02979428 0,14379861 0,85795051 0,02656563 -0,025606051

573 GSM1213771 2 83,87 0 7,38 0 7,384 -15,177247 0,74110923 0,44759147 0,04034917 0,08235517 0,77017285 0,01993933 -0,029410354

574 GSM1213772 IB 87,93 0 7,44 0 7,436 -2,9890046 1,03271431 0,12032041 0,10366171 0,20035892 0,58436122 0,05050194 -0,009428876

575 GSM1213778 1A 67,64 0 5,67 0 5,667 55,5885964 0,83412978 0,28768916 0,07895333 0,14049677 0,96479956 0,01667089 -0,048839305

576 GSM1213786 IB 73,79 0 5,96 0 5,958 -8,9317451 0,49498257 0,34749468 0,08050768 0,08861412 0,93496534 0,06664796 -0,023195534

577 GSM1213789 IB 80,34 1 1,83 1 0,709 47,7539786 0,89012541 0,33823882 0,00836333 0,11871503 0,83631167 0,01582256 -0,052870805

578 GSM1213790 IB 67,29 0 5,18 0 5,183 -88,378037 0,82259304 0,37728158 0,12130732 0,30467285 0,78644079 0,07975305 -0,011198245

579 GSM1213791 1A 69,07 1 5,18 NA 0,077 -26,742944 0,81474849 0,37535722 0,09180979 0,12430588 0,86831909 0,04367209 -0,035537594

580 GSM1213796 2 61,86 1 5,6 0 5,604 25,1710201 0,87049095 0,24599969 0,0325497 0,12896282 0,80842193 0,01601562 -0,017347748

581 GSM1213802 2 63,8 0 4,73 0 4,726 49,7439139 0,62700696 0,14120069 0,08194947 0,08357568 0,68026261 0,01478449 -0,012930499

582 GSM1213813 IB 71,35 1 0,95 0 0,947 138,197646 0,62459101 0,27813326 0,01247205 0,05036978 0,04662816 0,01544138 -0,007978442

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. Po fibro epith. vess. CD14 CD19

No surv. (years) CD56 neutro

(years)

583 GSM1213815 2 73,4 0 4,76 0 4,761 96,547608 0,43781195 0,46410811 -0,0054091 0,08746621 0,82585722 0,03118561 -0,044615875

584 GSM1213817 IB 69,62 1 3,46 0 3,461 64,7092239 0,45806093 0,33194717 0,08862095 0,05157912 0,94543241 0,01936964 -0,031340393

585 GSM1213821 IB 64,6 0 11,39 0 11,392 29,8115772 0,496433 0,28579157 0,08321137 0,09890888 0,8072885 0,04794954 0,016700255

586 GSM1213822 IB 55,68 0 12,04 0 12,036 -79,004324 0,76986309 0,26412058 0,10155243 0,06015907 0,84246018 0,0317492 -0,013463668

587 GSM1213828 1A 72,76 1 2,49 1 1,128 13,9648112 0,4848291 0,37900692 0,07221607 0,15411016 0,40850777 0,03947585 -0,004434717

588 GSM1213829 2 63 0 1,37 0 1,369 81,1507796 0,52735702 0,27632373 0,01099132 0,06706582 0,60408861 0,00717146 -0,033938942

589 GSM1213830 1A 54,83 0 8,34 0 8,339 133,684439 0,7262179 0,35018381 0,04540977 0,08209469 0,80459333 0,00541801 -0,048513373

590 GSM1213835 IB 85,48 1 1,97 1 1,881 -3,3258963 0,72415922 0,23359556 0,07056592 0,16600334 0,94160178 0,03706039 -0,042045665

591 GSM1213838 2 82,71 0 3,85 0 3,855 70,3119348 0,51550923 0,31081135 0,18749944 0,1682332 0,81108034 0,04424479 -0,041043961

592 GSM1213839 2 52,4 1 1,35 1 0,093 106,302104 0,67749985 0,39829124 0,03004466 0,13855677 0,3615638 0,02633847 -0,030679443

593 GSM1213841 2 73,45 1 6,47 1 2,927 115,814726 0,37316592 0,5243098 0,04953419 0,04980114 0,31290492 0,06837634 0,018335527

594 GSM1213843 IB 61,07 1 7,74 0 7,737 1,24547773 1,149994 0,2298783 0,05478045 0,13080561 0,58675612 0,04291948 -0,012912038

GSE10245 (histology : SCC)

595 GSM258553 2 63 0 5,883333333 1 5,841666667 127,779819 0,37978258 0,36191674 0,01261597 0,11284883 0,86656849 -0,0062398 -0,033028113

596 GSM258555 2 61 0 5,058333333 0 5,058333333 305,859871 0,36497048 0,32427501 0,01478296 0,00445531 0,07829642 -0,0414857 0,003723614

597 GSM258556 IB 60 0 5,225 0 5,225 67,526106 0,4472621 0,20595406 0,05674253 0,14928462 0,70161664 0,00594681 0,006542319

598 GSM258557 IB 79 0 4,241666667 0 4,241666667 121,847734 0,79191894 0,27897116 0,05912174 0,20808509 0,95361576 0,00172707 -0,027758237

599 GSM258562 2 55 1 0,875 1 0,45 106,415246 0,42224259 0,06835429 0,04174722 0,04788879 0,60727365 -0,008566 0,005929699

600 GSM258563 IB 65 0 4,4 0 4,4 86,8980337 0,93470925 0,41491841 0,045151 0,13218455 0,78201334 -0,0194756 0,002688785

601 GSM258565 IB 70 0 3,358333333 0 3,358333333 237,516119 0,53512734 0,1975094 0,03187075 0,09726368 0,45006515 -0,0304683 -0,024358099

602 GSM258566 IB 76 0 4,666666667 0 4,666666667 182,02989 0,50422128 0,28314348 0,02274952 0,07432869 0,46734154 -0,0172677 -0,021359299

603 GSM258570 3 39 1 0,566666667 1 0,566666667 118,142467 0,48388292 0,34251585 0,0338712 0,0314696 0,71234523 -0,0078883 0,014482364

604 GSM258578 IB 61 0 3,65 0 3,65 114,028422 0,4077153 0,27892796 0,03632743 -0,0638452 0,5989339 -0,0190025 0,068846298

605 GSM258580 1A 75 0 3,091666667 0 3,091666667 74,110174 0,41661244 0,05878094 0,08302733 0,22511905 0,83188734 0,04202607 -0,029146128

606 GSM258583 2 63 0 3,633333333 1 2,1 0,48900853 0,93659677 0,23030798 0,06408861 0,23272755 0,7580007 -0,0006141 -0,01680846

607 GSM258585 IB 74 0 3,15 0 3,15 34,9546256 0,78528528 0,15673383 0,19585476 0,26730125 0,85064785 0,00606928 -0,034671638

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fib

No surv. (years) Po ro epith. vess. CD14 CD19

CD56 neutro

(years)

608 GSM258594 3 64 0 2,375 0 2,375 154,694517 0,62649131 0,23373463 0,0319277 0,09726904 0,6735032 -0,024258 -0,049683662

609 GSM258596 2 75 0 1,558333333 0 1,558333333 68,3247083 0,65866563 0,14386022 0,05630651 0,09775411 0,93336635 -0,0090805 -0,032364613

610 GSM258599 2 56 0 2,35 1 0,925 118,493724 0,54949917 0,48638593 0,01605651 0,14552013 0,74696372 0,00295493 -0,024397543

GSE37745 (histology : SCC)

611 GSM1019138 2 66 0 9,35797399 0 7,22465753 165,926813 0,28889621 0,15813005 0,02824557 0,11361574 0,602076 -0,009134 -0,029146239

612 GSM1019141 2 72 1 0,0164271 NA NA -0,2765206 0,87794512 0,2015626 0,01514743 0,18307784 0,68783394 0,01647062 0,008985777

613 GSM1019142 IB 63 0 8,64613279 NA NA -62,161861 0,66397095 0,23554553 0,06714947 0,27479227 0,70715788 0,04756688 0,01967197

614 GSM1019146 2 76 1 1,36618754 1 0,76438356 99,5133104 0,59841898 0,33346288 0,04922459 0,05903276 0,51352699 -0,0078227 0,030333473

615 GSM1019151 2 62 0 8,00273785 NA NA 258,956025 0,34312129 0,1805796 0,03030886 0,052783 0,67569493 -0,0321808 0,00225165

616 GSM1019156 IB 80 1 0,43258042 NA NA -14,638646 0,90120098 0,23389524 0,04417454 0,16474482 0,75893099 0,01652026 0,008575464

617 GSM1019157 IB 70 1 1,62628337 0 1,35616438 164,079727 0,37217072 0,43666136 0,00759792 0,10348859 0,78612415 -0,0156474 -0,003747568

618 GSM1019159 IB 55 1 0,29842574 1 0,23013699 34,682498 0,35157593 0,09781006 0,09994553 0,12608798 0,71429388 0,02331595 -0,020697325

619 GSM1019168 3 59 0 14,6173854 NA NA 83,4259977 0,29423598 0,15294309 0,03284565 0,06099966 0,70003305 0,00046034 -0,020820626

620 GSM1019172 2 60 1 1,26488706 1 1,09863014 66,9901774 0,29639856 0,23367581 0,04758987 0,03134689 0,65106953 0,01668717 -0,007362469

621 GSM1019177 2 70 1 5,30595483 NA NA 218,534122 0,14081468 0,14023017 0,04367102 0,03675629 0,31768316 0,00680299 -0,01110576

622 GSM1019184 IB 71 1 1,17453799 1 0,6630137 46,3318727 0,23519973 0,5977093 0,01132314 0,0689104 0,45884902 0,00866641 0,005619811

623 GSM1019191 IB 80 1 0,26830938 0 0,10136986 37,6419193 0,39832341 0,19143014 0,04100455 0,0739422 0,62276446 0,00587106 0,024961978

624 GSM1019193 IB 69 1 6,29705681 1 3,57534247 39,5829463 0,65233411 0,23592568 0,12975438 0,09388484 0,7179547 -0,0084339 0,014720338

625 GSM1019195 3 58 1 1,21560575 1 0,92054795 203,658938 0,22631004 0,42977037 -0,006336 -0,0553143 0,66379061 -0,0327382 0,037430679

626 GSM1019198 2 75 1 0,33675565 0 0,28219178 63,4731171 0,91974313 0,22398748 0,03458513 0,13755653 0,43077667 0,00915756 0,005009658

627 GSM1019199 IB 75 1 7,49897331 0 7,49589041 111,746771 0,26594927 0,26842372 0,04355686 0,09925833 0,70850897 -0,0102608 -0,019697356

628 GSM1019201 IB 62 0 13,5386721 1 11,660274 182,886373 0,95287469 0,47311445 -0,0058241 0,05726136 0,41453687 -0,0250287 -0,053640173

629 GSM 1019202 3 60 1 0,91444216 1 0,89041096 151,289903 0,56581633 0,429521 -0,0029549 0,11703649 0,70253339 -0,0098587 -0,042435144

630 GSM 1019206 3 41 1 0,76933607 1 0,19452055 184,716101 0,8670911 0,3333708 -0,024296 -0,0345406 0,68137919 -0,0214428 0,007726597

631 GSM 1019209 IB 62 1 4,82135524 0 4,63013699 -3,1969267 0,64066778 0,35984005 0,07953434 0,17235224 0,76351487 0,01378852 -0,009025265

632 GSM1019212 IB 61 0 12,347707 0 11,8191781 -19,640933 0,85308138 0,40167616 0,07695751 0,16544953 0,87799196 0,04131719 -0,027914127

633 GSM1019215 IB 65 1 8,76659822 1 8,57534247 268,187774 0,52556404 0,20483777 0,01325825 0,07375615 0,25974314 -0,0088049 -0,02692068

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. fibro epith. vess. CD14 CD19

No surv. (years) Po CD56 neutro

(years)

634 GSM1019221 3 65 1 0,24366872 1 0,17534247 118,319216 0,31124428 0,30248883 0,00829134 0,0276988 0,62215848 -0,0085185 0,001884427

635 GSM 1019226 2 74 1 1,52224504 0 1,54520548 61,594606 0,3584947 0,57331063 0,02358264 0,12668346 0,71905931 0,01109526 -0,044955111

636 GSM 1019227 IB 61 1 1,27857632 0 1,0739726 157,052845 0,29210559 0,2578232 0,01116252 -0,0433486 0,29830027 -0,0011929 0,036917992

637 GSM 1019229 IB 58 1 9,0403833 0 9,17260274 185,815031 0,42361058 0,16651172 0,01456586 0,1757362 0,70709807 0,01785601 -0,046599732

638 GSM1019232 IB 70 1 14,5407255 0 14,7534247 79,8454388 0,29396145 0,1810799 0,05713275 0,0702087 0,51366633 0,00736964 -0,014854805

639 GSM1019233 3 66 1 6,17385352 0 6,23287671 120,845697 0,55692042 0,4618809 0,04478007 0,06078545 0,18012173 -0,0172221 -0,015742854

640 GSM1019235 IB 66 1 0,26557153 NA NA 211,287012 0,35148335 0,12587231 0,02590594 0,03987478 0,36767132 0,00622634 0,025620222

641 GSM1019238 IB 78 1 3,46064339 NA NA 119,176102 0,39885509 0,63671712 -0,0179697 0,09204925 0,71976623 -0,0093846 -0,057225723

642 GSM 1019240 2 75 1 2,93771389 NA NA 104,372072 0,63731256 0,42484682 -0,0016879 0,0678077 0,82966304 -0,0202825 -0,008082681

643 GSM1019241 IB 80 1 3,1156742 NA NA 91,6968813 0,76013806 0,30286637 0,04195468 0,06577297 0,77333811 -0,0095032 -0,02913751

644 GSM 1019245 3 56 1 0,39151266 NA NA 138,062797 0,5839304 0,27823806 0,02533442 0,07589812 0,45715588 -0,0078246 -0,010599277

645 GSM 1019246 1A 67 1 3,67693361 NA NA 73,5551606 0,68983147 0,34487999 0,04581606 0,17280003 0,6595961 0,01280114 -0,013175577

646 GSM 1019250 IB 67 0 8,55852156 0 6,58630137 150,519975 0,3518849 0,3421528 -0,0187084 0,01019099 0,14997865 -0,0111381 -0,006791351

647 GSM1019251 IB 62 1 2,90485969 NA NA 67,3657681 0,85122419 0,31531268 0,01038672 0,08772733 0,86486264 -0,0020507 -0,034771933

648 GSM 1019252 1A 76 1 1,71115674 1 1,11506849 155,780147 0,34522826 0,3093916 0,03195917 0,04303527 0,63292338 -0,0264631 -0,007544218

649 GSM 1019255 IB 73 0 7,57563313 NA NA 169,126194 0,11820786 0,07865565 0,01566181 0,12875048 0,83576958 0,02360327 -0,028079026

650 GSM1019263 IB 62 1 2,0752909 NA NA 65,5724215 0,65125459 0,28167483 0,04757715 0,03380552 0,2053381 0,0272784 0,036240463

651 GSM1019266 2 67 0 6,88295688 NA NA 98,8434226 1,01462812 0,51952564 -0,0268919 0,08701618 0,55529672 -0,0153892 -0,04779267

652 GSM1019267 2 57 1 2,49691992 NA NA 86,3880958 0,31773784 0,32012589 0,04541176 0,13009629 0,56742992 0,02719051 0,008275021

653 GSM1019269 IB 69 1 4,28473648 NA NA 41,0502038 0,49406113 0,25880002 0,04195453 0,10885473 0,64885439 -0,000161 -0,039383617

654 GSM1019271 IB 65 0 5,96030116 NA NA 115,213989 0,41240604 0,37670386 0,00851908 0,09089461 0,69010689 -0,0077131 -0,036697607

655 GSM1019276 1A 68 1 2,97604381 NA NA 88,5451399 0,37847706 0,27108325 0,07176526 0,10501112 0,8369206 -0,0080835 -0,042258859

656 GSM 1019277 IB 78 0 5,65639973 NA NA 83,7634368 0,26227658 0,137169 0,09027038 0,07633674 0,42217817 0,00600205 -0,005020858

657 GSM1019278 IB 67 0 5,724846 NA NA 186,636411 0,51326381 0,27993796 0,01072294 0,10095985 0,87106307 -0,0095533 -0,037524293

658 GSM 1019279 3 56 1 4,04654346 NA NA 186,488359 0,11792175 0,26534158 0,03578672 0,01999692 0,32019573 -0,011353 -0,022944814

659 GSM1019280 IB 84 1 4,41341547 NA NA 207,996298 0,15745948 0,1209199 -0,0115926 0,09288139 0,7258488 -0,0219373 -0,039353376

660 GSM1019281 1A 58 1 5,85352498 NA NA 172,39769 0,68591316 0,24152561 -0,0076366 0,13000715 0,5639578 0,00182082 -0,036638008

dis. free

Pt over, over. surv. CD8 eosino

GSM stage age recur. surv. 14 CD19

No surv. (years) Po fibro epith. vess. CD

CD56 neutro

(years)

661 GSM1019282 IB 77 1 4,16974675 NA NA 99,3515963 0,11777465 0,0609768 0,04469685 0,05469288 0,61664227 0,0111438 -0,022434439

662 GSM 1019284 IB 51 1 2,48049281 NA NA 132,462822 0,74317764 0,32303035 0,00505319 0,11845468 0,67959188 -0,0097671 -0,047866933

663 GSM1019291 IB 62 1 1,98767967 NA NA 197,344184 0,25249119 0,39563101 0,01965587 0,05835722 0,45068685 -0,0062278 -0,002710669

664 GSM1019293 2 70 1 1,80971937 1 1,02465753 130,978347 0,5464943 0,35537848 0,00996683 0,09159959 0,81600806 0,00234986 -0,031420567

665 GSM 1019294 IB 68 1 3,54004107 NA NA 198,182048 0,3078682 0,04879548 0,0362338 -0,0262107 0,86336047 -0,0256012 0,005202787

666 GSM1019296 2 66 1 2,16837782 NA NA 194,482551 0,85919926 0,17855744 -0,0054497 0,05756835 0,40331192 -0,0181127 -0,028564066

667 GSM 1019297 3 61 1 0,32306639 NA NA -25,923484 0,72106933 0,22616249 0,08952404 0,24963932 0,80076538 0,0095704 0,031373816

668 GSM1019306 2 65 1 3,42231348 NA NA 32,7865378 0,58354781 0,34360011 0,06746176 0,13830888 0,35798097 0,01725087 0,013798839

669 GSM1019307 1A 50 1 3,08008214 NA NA 22,9068597 0,303827 0,15237533 0,07012626 0,08538557 0,54213049 0,02787846 0,0020583

670 GSM1019319 1A 70 1 0,49555099 1 0,32328767 -77,233605 0,55513897 0,27119157 0,05672779 0,2121413 0,70547125 0,07129811 0,028745715

671 GSM1019322 3 58 1 0,62696783 NA NA 206,802657 0,63400719 0,22547192 0,01312968 0,00062569 0,12526197 -0,0214545 0,006359869

672 GSM1019323 3 72 1 0,93634497 NA NA 37,4476471 0,61996278 0,32640657 0,01121411 0,07661143 0,50497841 0,01715457 -0,012865897

673 GSM1019325 1A 77 1 1,96577687 1 1,64931507 -82,737227 0,55338396 0,29978771 0,05690873 0,21000286 0,78028319 0,08366779 0,026376662

674 GSM1019326 2 70 0 14,973306 0 12,4575342 118,751123 0,90598545 0,42298951 0,01162527 0,07357134 0,86125119 -0,0144055 -0,054312314

675 GSM1019329 1A 40 0 7,2991102 NA NA 66,0803527 0,54325159 0,57764211 0,04289919 0,14485516 0,72547942 0,0181012 -0,037357662

676 GSM1019331 IB 71 1 1,7522245 1 0,65479452 219,109891 0,35218884 0,12066189 0,01511682 0,03146575 0,67968304 -0,0237584 -0,024826393

Pt No: patient number β₀: constant calculated using the approach described in Example 1

ADC: lung adenocarcinoma fibro : fi ro iasts calculated using the approach described in Example 1

ADSQ: adeno-squamous carcinoma epith. : epitheiiai calculated using the approach described in Example 1

LCC: large cell carcinoma vess. : vesseis calculated using the approach described in Example 1

SCC: squamous cell carcinoma CD14 : c_D calculated using the approach described in Example 1

stage : stage of lung cancer (1 A, 1 B, 2 or 4) CD19 : CDI9 calculated using the approach described in Example 1

age: age in years CD8_CD56 : estimated coefficient, calculated using the approach described over. surv. : overall survival (0=alive, 1 =dead) Example 1 , associated with the CD8 and CD56 subpopulations

over. surv. (years) : overall survival in years before death or lost from sight Eosino_neutro : estimated coefficient, calculated using the approach described recur. : recurrence (0=no recurrence, 1 recurrence) Example 1 , associated with the eosinophils and neutrophils subpopulations dis. free. surv. (years) : disease free survival in years before recurrence

For each patient, the inventors estimated the coefficients associated with each of the subpopulations fibroblasts, epithelial cells, vessels cells, CD14 cells, CD19 cells, CD8 cells, CD56 cells, eosinophils and neutrophils, using the deconvolution method disclosed in Example 1 , as well as the coefficients associated with the combination of the subpopulations CD8 cells and CD56 cells, and eosinophils and neutrophils.

From the coefficients estimated for patients of the cohort suffering from adenocarcinoma, they build a decision tree using the CART modeling algorithm from the R package (Goerg (2013) Licors: Light cone reconstruction of states - predictive state estimation from spatio-temporal data. R package version 2.0) depicted on Figure 18.

Briefly, the CART modeling algorithm aims at explaining a variable Y from explanatory variables and in particular at determining how the observations of Y can be gathered according to the observations of the explanatory variables. In the present decision tree, each knot corresponds to a question involving an explanatory variable. For each knot, if the i^th observation of that explanatory variable responds positively to this question, the i^th observation of Y falls in the left branch following the knot. The leaves gather all the corresponding observations of Y. The mean value of these observations is then used as coefficient in a regression model which involves identity functions.

This decision tree enabled distinguishing a subgroup of 159 patients (group A of Figure 18) from other patients (groups B, C, D, E, F, G, H, I, J, K and L of Figure 18), who display a coefficient associated with the vessels subpopulation superior to 0.1099, and who did not had recurrence. The mean value of the coefficient associated with the vessels subpopulation observed in this group of patients A was called "high score".

The inventors further demonstrated on overall survival curves (Figure 19) and disease free survival curves (Figure 20) that patients displaying such a high score of the coefficient associated with the vessels subpopulation had a better survival than patients displaying a low score of the coefficient associated with the vessels subpopulation.

This example thus confirms that, by modeling the global transcriptional expression level pattern of genes from a biological sample from a tumor according to the transcriptional expression level pattern of these genes in specific subpopulations from the tumor stromal environment, it is possible to distinguish patients with a good prognosis from patients with a poor prognosis.

Claims

1 . A method for determining prognosis of a patient suffering from cancer, comprising:

A) determining the global transcriptional expression level pattern Y of at least N genes in a biological sample from the tumor of said patient, wherein N is an integer≥ 9

v — a a v veplthelial , n _v y ibroblasts ■ a _v γ vessels ■ a

' — Pa ' P epithelial ^{x Λ} τ P fibroblasts ^{x Λ +} Pvessels ^{x A} FCD14

X X^C014 + ficDW ^x X^{CD lg} + ficDSG ^x X ^{[)S (}' + ficBB X X^C + β eosinophils v veosinophUs i _v ytieutrophlls

-r PrieutropMls ^Λ

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

3fibrobiasts is the estimated coefficient associated with the fibroblasts subpopulation, ^fibroblasts j_s ^_Q transcriptional expression level pattern of said n genes in the epithelial cells subpopulation, 3_Vesseis is the estimated coefficient associated with the vessels endothelial cells subpopulation,

^vessels jg ^_e transcriptional expression level pattern of said n genes in the vessels endothelial cells subpopulation,

(NK cells) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

^eosinophils j_s ^_e transcriptional expression level pattern of said n genes in the eosinophils subpopulation,

3neutrophiis is the estimated coefficient associated with the neutrophils subpopulation, ^neutrophils j_s ^_e transcriptional expression level pattern of said n genes in the neutrophils subpopulation,

by estimating the estimated coefficients by partial deconvolution using the least squares method or the ridge method, D) based on the coefficients estimated in step C), determining whether said patient has a good or poor prognosis.

2. The method according to claim 1 , wherein the prognosis is global survival prognosis or survival without relapse prognosis.

3. The method according to claim 1 or 2, further comprising a step C) of determining at least one ratio between at least two coefficients estimated in step C), and wherein step D) is carried out on the basis of said at least one ratio determined in step C).

4. A method for stratifying patients suffering from cancer based on the transcriptomic pattern of cell subpopulations from their tumor stromal environment, comprising:

v— o a v vepitkelial , a _v ψ ibroblasts , _v vvesseis o

¹ - Po + PepliheUal ^{x Λ} ' P fibroblasts ^Λ + Pvessels ^{x Λ} + PCD\* x X^{CD l4} + ficD w ^x X^CDl9 + fi DS ^{x CD56} + cDo X X^CDS + v veosirtophils i a v or, when the cell subpopulations are gathered into 7 groups of cell subpopulations, according to the transcriptional expression level pattern X® of said genes in said 7 groups of cell subpopulations according to the following equation

r — PQ + epltheUal ^{x A +} P fibroblasts ^{x x} + Pvessels ^{x A} + PC014 v VCD14 yCD19 < ft WCD564-CD8

yeosino+neat™

β₀ is a constant,

(monocytes) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

5. A method for selecting a patient suffering from cancer for an anticancerous therapy targeting a specific cell subpopulation from tumor stromal environment, comprising:

v— o a v vepitkelial , a _v ψ ibroblasts , _v vvesseis o

¹ - Po + PepliheUal ^{x Λ} ' P fibroblasts ^Λ + Pvessels ^{x Λ} + PCD\* x X^{CD l4} + ficD w ^x X^{CD l9} + fi DS ^{x CD56} + cDo X X^CDS + (^eosinophils v veosirtophils i a v yneutrophils

^" ' ne trop lls ^{Λ Λ}

or, when the cell subpopulations are gathered into 7 groups of cell subpopulations, according to the transcriptional expression level pattern X® of said genes in said 7 groups of cell subpopulations according to the following equation I — po + p epithelial ^{κ Λ +} fi blmts ^{x Λ} + Pvessete ^{Χ Λ} + PCD

K A -t pc .9 *^■* T PCDSS+CDS » Λ ^"Γ PeBstee+mMire v yeosiBO+iientre

wherein

Y is the global transcriptional expression level pattern of said n genes,

β₀ is a constant,

(monocytes) subpopulation,

(NK cells) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

6. The method according to claim 5, wherein said patient is selected for an anticancerous therapy targeting the cell subpopulation, the estimated coefficient of which has been determined as the highest in step C).

7. A method for determining the response of a patient suffering from cancer to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment, comprising:

B) providing the transcriptional expression level X^G) of said at least N genes from biological samples from the following 9 cell subpopulations j from a tumor stromal environment: epithelial cells, fibroblasts, vessels endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), CD56 cells (NK cells), CD8 cells, eosinophils and neutrophils, wherein said cell subpopulations may optionally be gathered into the following 7 groups of cell subpopulations from a tumor environment: epithelial cells, fibroblasts, vessel endothelial cells, CD14 cells (monocytes), CD19 cells (B cells), the group consisting of CD56 cells (NK cells) and CD8 cells, and the group consisting of eosinophils and neutrophils, C) modeling said global transcriptional expression level pattern Y of n genes, wherein 9<n<N, according to the transcriptional expression level pattern X® of said genes in said 9 cell subpopulations according to the following equation

v — a j- a v veplthelial , <> _v γ fibroblasts , o _v v vessels , o ϊ — p₀ 1- p epitheli l ^{x Λ} ' P fibroblasts ^{x A "}·^" P vessels ^{x Λ} ' PCD l*

X X^{CB l4} + ?CDI9 ^x j^cow + ^_CDS6 x A'^C£)56 + βαοΒ X X^C08 + β_β05ί_ηθρΜΐί v yeesiK£»i» ls o _v yneutrophlls

-r PftetitropAils ^Λ

— At + Pe≠theUal + Pfibroblasts ^{χ λ} + Ppessets ^{Κ Λ} + FCM4

X A f PCBl.9 Χ Λ " FCD56+CD8 *^■* T P«Sf«#+t1.«Mt"£l v Λ Λ yeeias+«i§atre

wherein

Y is the global transcriptional expression level pattern of said n genes,

βο is a constant,

3CD56 is the estimated coefficient associated with the CD56 cells (NK cells) subpopulation, X^CD56 is the transcriptional expression level pattern of said n genes in the CD56 cells (NK cells) subpopulation,

3CD8 is the estimated coefficient associated with the CD8 cells subpopulation,

D) based on the coefficients estimated in step C), determining the response of said patient to an anticancerous therapy targeting a specific cell subpopulation from the tumor stromal environment.

8. The method according to any one of claims 1 to 7, wherein said modeling step C) comprises a step (a) of homogenizing the transcriptional expression levels of the 9 cell subpopulations or of the 7 groups of cell subpopulations by:

9. The method according to any one of claims 1 to 8, wherein said modeling step C) comprises a step (b) of selecting the n genes to be used among said N genes, said selecting step comprising: (b1 ) determining the median transcriptional expression level of each gene in each cell subpopulation or group of cell subpopulations to obtain a "median subject" for each cell subpopulation or group of cell subpopulations,

(b2) withdrawing control genes from the N studied genes,

(b3) withdrawing sexual genes from the N studied genes,

(b4) withdrawing the genes the expression level of which is inferior to a reference value in each sample of each subpopulation or group of subpopulations, and

(b5) withdrawing housekeeping genes from the N studied genes, said housekeeping genes being preferably identified, using the kmeans ++ method, as the genes, the variance of which, calculated on the 9 "median subjects" determined at step (b1 ), is the lowest;

10. The method according to any one of claims 1 to 9, wherein the patient suffers from lung cancer.

11. The method according to any one of claims 1 to 10, wherein the global transcriptional expression level Y is obtained in step A) using DNA microarrays.

12. The method according to any one of claims 1 to 1 1 , wherein N is superior to 54 500.

13. The method according to any one of claims 1 to 12, wherein n is comprised between 1 157 and 2521 .

14. The method according to any one of claims 1 to 12, wherein n is 140.

15. The method according to any one of claims 1 to 14, wherein said step C) is implemented by a computer.