WO2010069008A1 - A germline competent cell derived from adult tissue - Google Patents

A germline competent cell derived from adult tissue Download PDF

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WO2010069008A1
WO2010069008A1 PCT/AU2009/001665 AU2009001665W WO2010069008A1 WO 2010069008 A1 WO2010069008 A1 WO 2010069008A1 AU 2009001665 W AU2009001665 W AU 2009001665W WO 2010069008 A1 WO2010069008 A1 WO 2010069008A1
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cell
cells
mrna
homo sapiens
isolated mammalian
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WO2010069008A9 (en
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Catherine Browne
Alan Mackay-Sim
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Griffith University
The University Of Queensland
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Publication of WO2010069008A9 publication Critical patent/WO2010069008A9/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]

Definitions

  • THIS INVENTION relates to pluripotent mammalian cells and to methods of isolating, culturing and using same.
  • Pluripotent cells are cells that have the potential to differentiate into all cell types found in an adult organism, except for certain placental tissue and umbilicus. These cells naturally occur in the inner cell mass of an embryo and they differentiate to form three embryonic germ layers: ectoderm, endoderm and mesoderm. It is from these three germ layers that all adult tissues in a human are formed. There is considerable interest in using pluripotent cells in drug development and discovery, gene therapy and cell and tissue therapy. There has been clinical application of these cells in in vitro fertilisation and tissue and cellular regeneration and replacement therapies.
  • Pluripotent cells known to date may be classified into 3 groups.
  • the first of these includes cells derived predominantly from embryonic tissue such as: (i) embryonic stem cells (ESCs), which are derived by long-term culture of cells from the inner cell mass of a blastocyst (Thomson et al. 1998 Science 282:1145-1147); and (ii) embryonic germ cells (EG cells), which are derived from migratory primordial germ cells found in the region of the hind gut in transit to the genitalgonadal ridge in E8.5 - E9.5 mouse foetuses (Shamblott et al. 1998 PNAS USA 10:13726-31). EG cells of a late embryo have many of the properties of ESCs.
  • ESCs embryonic stem cells
  • EG cells embryonic germ cells
  • the primordial germ cells in an embryo develop into stem cells that in an adult generate the gametes. These cells are generally derived from embryos (created naturally or via cloning), fetal tissue or via the mixing of nucleus and cytoplasm of multiple species. Reprogramming of somatic cells to cells exhibiting pluripotent properties has been achieved by nuclear transplantation of a somatic nucleus into an enucleated egg. There are ethical issues that arise from the derivation of these cells.
  • a second group includes those cells obtained by introducing defined transcription factors into somatic cells.
  • induced pluripotent stem cells Cells formed by expression of a combination of transcription factors (e.g SOX2, OCT-3/4, NANOG and KLF4) expressed from a retrovirus or other compounds are referred to as "induced pluripotent stem cells” or “iPS cells” (Takahashi & Yamanaka, 2006, Cell 126:663-676).
  • transcription factors e.g SOX2, OCT-3/4, NANOG and KLF4
  • adult stem cells have been thought not to be pluripotent although recent studies have cast some doubt on this thinking. In this context some adult stem cells are thought to represent a third class of pluripotent cells.
  • the in vivo developmental potency of a given cell may be determined by assessing for germline competency or, for teratoma formation in an immune deficient animal.
  • a "germline competent" cell is capable of giving rise to functional gametes.
  • One form of assessing germline competence includes injecting a candidate cell into a blastocyst and determining whether Fl derived from an intercross involving a founder derived from the blastocyst contains the genetic complement of the candidate cell.
  • Germline competency is a defining feature of all pluripotent cells.
  • teratoma - a tumour containing tissue that is characteristic of endodermal, ectodermal and mesodermal lineages- is also understood to indicate that the candidate cell has pluripotency in vivo. All pluripotent cells known to date - ESCs, EG cells and iPS cells - have this defining property. It is generally understood that teratoma formation occurs as a consequence of a
  • reprogramming of the cell during culture to differentiate when placed in an environment in the absence of LIF. That is, the differentiation is a function of the cell itself, rather than stimuli from the tissue environment in which it is placed.
  • inner cell mass cells generally do not form teratomas whereas ESCs do.
  • Teratoma formation is generally understood to be a significant limitation to the use of all pluripotent cells identified to date in clinical applications. More particularly, it is generally understood that there is a significant risk that pluripotent cells identified to date will cause teratomas or other forms of neoplasia or unregulated cell or tissue growth if used in clinical applications.
  • the present invention is broadly directed to a mammalian pluripotent stem cell that is obtainable from adult cells and/or tissues.
  • a preferred advantage of the mammalian pluripotent stem cell is that it does not form teratomas.
  • an isolated mammalian cell having the developmental potency of an embryonic stem cell (ESC), characterised in that the isolated mammalian cell does not form a teratoma when provided in an immune deficient animal.
  • the isolated mammalian cell is a germline competent, pluripotent stem cell.
  • the isolated mammalian cell may be further characterized by a presence, absence, relatively high or relatively low level of expression of one or more genes or proteins set forth in Tables 1-12.
  • the invention provides:
  • the invention provides a method of producing a mammalian cell, said method including the step of culturing a one or more cells or tissues obtained from a mammal in a medium including one or more of FGF9, FGF2, SCF and LIF, to thereby produce the isolated mammalian cell.
  • the method includes culturing neurospheres or a neurosphere-like cellular mass in a medium comprising one or more of FGF2, FGF9, SCF and/or leukaemia inhibitory factor (LIF).
  • a medium comprising one or more of FGF2, FGF9, SCF and/or leukaemia inhibitory factor (LIF).
  • the medium includes one or more of FGF2, FGF9, SCF, LIF, TGF- ⁇ 2 and/or BMP-4.
  • the method includes: (a) forming a neurosphere or a neurosphere-like cellular mass; and (b) isolating the mammalian cell from the neurosphere or neurosphere-like cellular mass, thereby providing the isolating mammalian cell.
  • the one or more cells or tissues, inclusive of the neurosphere or a neurosphere-like cellular mass are obtainable from adult olfactory epithelium.
  • This aspect of the invention also provides an isolated mammalian cell obtainable by the method of this aspect.
  • a method of producing a differentiated mammalian cell including the step of culturing the isolated mammalian cell of any of the aforementioned aspects under conditions which facilitate the production of the differentiated cell.
  • This aspect of the invention also provides a differentiated cell obtainable by the method of this aspect.
  • an isolated mammalian cell, or differentiated cell, transformed or transfected with an isolated nucleic acid there is provided an isolated mammalian cell, or differentiated cell, transformed or transfected with an isolated nucleic acid.
  • the isolated nucleic acid is, or is provided in, a genetic construct.
  • the isolated nucleic acid encodes a therapeutic agent.
  • composition comprising an isolated mammalian cell according to the aforementioned aspects and/or a cell differentiated therefrom; and a suitable carrier, diluent or excipient.
  • a method of treatment of a disease or condition in a mammal including the step of administering an isolated mammalian cell according to the aforementioned aspects and/or a cell differentiated therefrom to said mammal to thereby treat said disease or condition.
  • an isolated mammalian cell according to the aforementioned aspects and/or a cell differentiated therefrom for use in treating a disease or condition mammal.
  • the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
  • the method further includes the step of implanting or otherwise transferring the blastocyst produced at step (i) to a female non-human mammal.
  • one or more isolated mammalian cells delivered at step (i) are genetically modified, wherein the progeny produced at step (ii) are genetically modified.
  • This aspect of the invention also includes a genetically-modified non-human mammal obtainable by the method of this aspect.
  • the invention provides a method of identifying, designing, screening or otherwise producing a compound having a desired activity, said method including the step of: (i) contacting a candidate compound with an isolated mammalian cell of any of the aforementioned aspects, or a cell differentiated therefrom; or (ii) administering a candidate molecule to a non- human mammal produced according to the method of the aforementioned aspect, to thereby produce a compound having said activity.
  • Non-limiting examples of activities include cell growth and/or differentiation, anti-tumour activity, pro- or anti-apoptotic activity, neuropharmacological activity; regulation of metabolism; hormonal activity; gene regulatory activity; cell cycle regulation and immunoregulatory activity,
  • the mammal is a preferably human, rat or mouse.
  • the non-human mammal is a rat or a mouse.
  • FIG. 1 Pluripotent adult stem cells were derived from adult olfactory mucosa.
  • Cells from adult, Rosa-EGFP mouse olfactory mucosa were grown as neurospheres, dissociated and cultured for 48 hours as an adherent monolayer of expanded neurospheres in the presence of EGF and FGF2 for 2 days.
  • the cells were then trypsinised and grown in POSE medium on mouse stromal feeder layers for 2 weeks (A) or 3 weeks (B) after which they were sorted on the basis of EGFP fluorescence, Y-axis, and forward scatter (X-axis (A, B).
  • Prior to sorting EGFP-negative cells were of similar undifferentiated phenotype (C). After sorting they were small and round (D).
  • E qPCR genotyping identified the EGFP amplicon in tail-tip DNA from 9 out of 13 live born offspring created from blastocyst injection of EGFP-dim cells (First experiment in G). Controls were DNA from non-transgenic mouse (WT negative control) and Rosa-EGFP mouse (EGFP-positive control). F: qPCR Control for FoxL2 amplicon from the same DNA samples.
  • G Summary Table of 67 separate blastocyst injections using EGFP-dim and EGFP-negative cells and different numbers of cells injected.
  • Figure 2 EGFP was detected in many tissues in chimeric mice and throughout the tissues of progeny of germ-line chimeras.
  • Immunochemistry detects EGFP in chimeric mouse generated from blastocyst injection of a single pOS cell (A-C). Small green dots are autofluorescence in blood cells which are also seen in controls (D-I).
  • D-F Negative control, adjacent section without primary antibody.
  • G-I Negative control, wild-type non-EGFP mouse with primary antibody. Images A-I are confocal, taken on the same settings, from similar regions of the embryo: A, D, G, head region showing brain (b); B, E, H, mid-region showing lung (Iu), skin (sk), dorsal root ganglia (drg); C, F, I, lower region showing liver (Ii), spinal cord (sc), stomach (st).
  • Y-axis shows log normalised intensity for each gene: Grey shows genes not detected or reduced in Negative pOS cells. Lighter shading shows genes expressed in Negative pOS cells but neither reduced or enriched. Darker shading shows genes enriched in Negative pOS cells.
  • B Relative expression in pOS cells of the chromatin modification subnetwork of PluriNet. Genes are shown that are significantly repressed or enriched in Negative pOS cells compared to Reference cells (p ⁇ 0.01). Low or no expression of two of the key pluripotency genes Nanog and Oct4 are also associated with low levels of expression of protein-partners and adjacent network members. The chromatin targets Myc, Klf4/5, HDACl are induced in pOS cells, as are the cell cycle subnetworks associated with PluriNet.
  • C Immunofluorescence for key pluripotency proteins. Left column: antibodies against: Sox2 (top line), Oct4 (2 nd line), Nanog (3 rd line) and Klf4 (bottom line).
  • Middle column the same cells imaged for D APIDAP-label led nuclei.
  • Right column merged images of other columns. Sox2, Oct4, and Nanog mRNAs were below detection thresholds on the microarray but their proteins were detected in about 10% of cells.
  • Figure 4 Fl, F2 offspring of FO chimaeras.
  • Detection of pOS cell-derived EGFP expression in first and second generation offspring of chimaeric founder mice On each slide the first column shows sections from the wild-type control reacted for anti-EGFP immunochemistry, the second column shows sections from the animals listed but without primary antibody, and the third column shows sections from the animals listed with primary antibody. Nuclei stained with DAPI. Endogenous EGFP expression visualised using a rabbit anti- EGFP primary antibody and an Alexa-488-conjugated goat anti-rabbit antibody. Each foetus is imaged using darkfield (DF), DAPI-labelled nuclei and EGFP filters, using an Olympus BX-51 fluorescent microscope and DP Manager software.
  • DF darkfield
  • DAPI-labelled nuclei and EGFP filters using an Olympus BX-51 fluorescent microscope and DP Manager software.
  • WT6 Wild-type, non-transgenic control FoI 1, Fo2, FoIO, FoI 3 - Chimaeric founders 11, 10, 13 and 2, respectively.
  • FoI 1/Fl 1 1st generation pup #1 bred from chimaeric founder #11.
  • F02/F11/F21 - 2nd generation pup #1 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
  • F02/F11/F22 - 2nd generation pup #2 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
  • F02/F11/F23 - 2nd generation pup #3 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
  • F02/F11/F24 - 2nd generation pup #4 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
  • F02/F11/F25 - 2nd generation pup #5 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
  • F02/F11/F26 - 2nd generation pup #6 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
  • Figure 5 EGFP immunochemistry in chimeric embryo SC14 after injection of a single pOS cell into a blastocyst.
  • A, C, E, G EGFP immunoreactivity in different tissues.
  • B, D, F, H Negative control - nearby sections without primary antibody showing autofluorescence, predominantly in blood cells.
  • C, D Sections through head showing developing brain (b).
  • E, F Sections through liver (i) and lung (Iu).
  • G, H Sections through spinal cord (sc) and dorsal root ganglion (drg). All images are composites of two images at different excitation and emission wavelengths: green (for EGFP), and red (for autofluorescence). All images show autofluorescent blood cells. Photomicrographs were taken on a Zeiss
  • Figure 6 qPCR for pluripotency gene expression in pOS cells. Positive controls (lighter shaded bars) indicate gene expression in primordial germ cells (PGCs) from El 1.5 embryos. Gene expression in pOS cells (darker shaded bars) and PGCs is expressed relative to the internal control, 18S ribosomal RNA sub-unit.
  • Figure 7 A: Mouse pOS cells; B: human pOS cells; and C: rat pOS cells.
  • Figure 8 Injection of 1 pOS cell into one blastocyst is sufficient to generate male and female chimaeric founder (Fo) mice and Fl offspring. PCR detection of an EGFP amplicon was performed using DNA obtained from Fl progeny of an Fo2 female.
  • Figure 10 Bar graph showing comparison of Sox2 and Oct4 expression by murine pOS cells, murine ES cells and murine embryonic fibroblast (MEF) cells.
  • the inventors have produced an isolated mammalian cell obtainable or derivable from adult mammalian tissue.
  • the isolated mammalian cell has germline competency, and therefore is by definition, a pluripotent stem cell.
  • the genetic complement of the isolated mammalian cell is inherited in Fl progeny formed from a founder mammal produced from a blastocyst into which the cell has been injected or otherwise delivered.
  • the genetic complement of the cell can be identified in tissues derived from ectodermal, endodermal and mesodermal lineages of mammals produced from a blastocyst into which the cell is delivered.
  • the inventors have observed that the isolated mammalian cell is unable to form a teratoma when provided in an immune deficient animal. Further none of the founders, Fl or progeny derived therefrom to date have been found to have neoplastic or other uncontrolled cell or tissue growth. The finding suggests that the culture methodology and/or conditions that the inventors designed to produce the isolated mammalian cell of the invention are unlike those for derivation of ESCs and EG cells in that they do not appear to reprogram the cell of the invention for teratoma formation. It will be understood that having produced a isolated mammalian cell capable of self renewal, that cell can then be produced by a variety of processes including those described further herein.
  • isolated material (e.g. cells) that has been removed from its natural state or otherwise been subjected to human manipulation. Isolated material may be partly, substantially or essentially free from components that normally accompany it in its natural state, or may be manipulated so as to be in an artificial state together with components that normally accompany it in its natural state.
  • isolated also includes "enriched” or “purified”, which in the context of cells, means that the frequency or proportion of cells after enrichment or purification is greater than before enrichment or purification.
  • an isolated mammalian cell having the developmental potency of an embryonic stem cell (ESC), the cell being characterised in that the cell does not form a teratoma when provided in an immune deficient animal.
  • ESC embryonic stem cell
  • the isolated mammalian cell is of human, mouse or rat origin.
  • An isolated mammalian cell having the developmental potency of an ESC is typically one that is capable of differentiating to form tissues derived from mesodermal, endodermal and ectodermal lineages. Typically the cell is also capable of self renewing proliferation.
  • An isolated mammalian cell having the developmental potency of an ESC is not a totipotent cell.
  • An ESC does not form extra embryonic tissues.
  • a "totipotent cell” is defined as a cell that may differentiate into an entire organism.
  • a totipotent cell has the capability to develop into a complete embryo including extra-embryonic cell types.
  • a "pluripotent cell” is generally understood as meaning a cell that may differentiate into all cell types that constitute an organism.
  • a pluripotent cell cannot develop into any extra-embryonic cell types.
  • Other cells that have the developmental potency of an ESC include embryonic germ cells (EG cells) and induced pluripotent stem cells (iPS cells). However, these cells form a teratoma when provided in an immune deficient animal.
  • the invention provides a pluripotent stem cell, that does not form a teratoma when provided in an immune deficient animal.
  • the pluripotent stem cell is obtainable, derivable or otherwise produced from adult tissue.
  • a teratoma is generally understood as meaning a malignant tumour that contains tissues derived from all three embryonic layers (mesoderm, endoderm and ectoderm) including bone, muscle, cartilage, nerve, tooth buds and various glands.
  • teratoma formation in an immune deficient, or immune compromised animal such as a SCID mouse had been regarded as a defining characteristic of pluripotency.
  • Assays for teratoma formation generally involve the injection of candidate pluripotent cells into such an animal and examination of the animal after a period in which a teratoma or related tumour would be expected to have formed without any other cell growth stimuli.
  • the isolated mammalian cell according to the invention is characterised in that it does not form a teratoma under these assay conditions.
  • the isolated mammalian cell retains an undifferentiated phenotype when provided in an immune deficient animal.
  • the cell may not differentiate in the immune deficient animal.
  • the cell after injection into an immune deficient animal the cell may retain capacity for self renewal.
  • the isolated mammalian cell may retain the developmental potency of an ES, EG or iPS cell.
  • the cell may retain the phenotype of a multipotent stem cell.
  • a “multipotent cell” is generally understood as meaning a cell that can develop into several cell types. A multipotent cell does not have the capability to develop into a complete embryo nor does it have the capacity to develop into all cell types that constitute an organism.
  • the cell may differentiate in the immune deficient animal to form tissue and cellular elements of the tissue in which it is placed. In other embodiments the cell may migrate to another site in the immune deficient animal or undergo cell death.
  • a germline competent cell is a cell that when injected into a blastocyst can give rise to germ cells. These germ cells can then give rise to progeny.
  • the invention provides a germline competent cell, that does not form a teratoma when provided in an immune deficient animal.
  • the germline competent cell is obtainable, derivable or otherwise produced from adult tissue.
  • the isolated mammalian cell hereinbefore described is obtainable, derivable or otherwise produced from adult cells or tissues.
  • Non-limiting examples include bone marrow, central nervous system tissue, neural tissue, skin, gut, pancreas, muscle, brain, heart, adipose, olfactory mucosa or other mucosa or epithelia.
  • the tissue is olfactory mucosa.
  • isolated mammalian cells of the invention may be characterized by levels of gene expression.
  • Levels of gene expression may be relative levels of gene expression compared to a Reference cell, or may be detected as the presence or absence of expression of a particular gene. Typically, although not exclusively, this may be through detection and/or measurement of RNA expression. This may be by transcriptome analysis or by mRNA expression profile analysis, for example. Suitable techniques for analysis of gene expression are provided in the Examples herein, inclusive of microarray analysis, RT-PCR, northern blotting and other techniques known in the art. The inventors have determined the protein-coding transcriptome of the isolated mammalian cell of the invention.
  • the inventors have compared the transcriptome with PluriNet genes - a regulatory network of genes that is shared by pluripotent ES cells, embryonal carcinomas and iPS cells - to identify genes in the isolated mammalian cell of the invention that are also expressed in these pluripotent cells.
  • PluriNet genes a regulatory network of genes that is shared by pluripotent ES cells, embryonal carcinomas and iPS cells - to identify genes in the isolated mammalian cell of the invention that are also expressed in these pluripotent cells.
  • certain genes that have been observed as being associated with pluripotency in these pluripotent cells are not actively transcribed in the isolated mammalian cells of the invention. These are Sox 2, Oct3/4, all of which appear to have little or no transcription, and Nanog which appears to have very little transcription.
  • the inventors recognise that the unique differences in mRNA expression profile of the isolated mammalian cell of the invention as compared with known pluripotent cells may mean that the isolated mammalian cell of the invention is incapable of forming teratoma because it does not have expression of certain genes that are observed in known pluripotent cells.
  • the invention identifies the genes that are transcribed in known pluripotent cells but not in the isolated mammalian cell of the invention as being tumourigenic genes that are not necessary for germline competency.
  • the isolated mammalian cell according to the invention does not contain, or contains relatively low amounts of Sox 2 or Oct3/4 mRNA.
  • the isolated mammalian cell does not contain, or contains relatively low amounts of one or more of SET, ZFP42, HMGBl or ARID38 mRNA.
  • the isolated mammalian cell does not contain, or contains relatively low amounts of one or more of the mRNAs shown in Table 3 herein.
  • the cell does not contain, or contains relatively low amounts of DNMT3b, HDAC2 and Nanog mRNA.
  • the isolated mammalian cell does not contain, or contains relatively low amounts of one or more mRNAs
  • the isolated mammalian cell does not contain a detectable level of the mRNA, or contains an amount that is significantly lower than in a
  • the isolated mammalian cell or population of said cells preferably contains a relative amount or abundance of said mRNA that is less than 50%, less than 40%, less than 30%, less than 20%, less than
  • a preferred Reference cell is a neurosphere-derived cell.
  • the isolated mammalian cell may contain SPl and/or
  • ANP32A mRNA ANP32A mRNA.
  • the isolated mammalian cell may contain one or more mRNAs shown in Table 2 herein.
  • the cell may contain one or more of Myc, HMGAl, SMARCADl, SMARCCl, PTMA, MCM6, PCNA, HDACl, KLF5, KLF4, BTBD14B, HoxA5, FoxAl, Meisl and/or ENl mRNA.
  • These mRNAs are enriched in the isolated mammalian cell of the invention as compared with Reference cells (described further herein) from which they are derived.
  • the isolated mammalian cell may express one or more genes at a level at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold or at least 20-fold greater than that of a Reference cell or cell population.
  • the cell may contain one or more mRNAs shown in Table 1 herein, wherein the Reference cell is, or derived from, expanded neurospheres.
  • the isolated mammalian cell has a profile of mRNA expression substantially as shown in Table 4 or Table 5 herein.
  • an isolated human cell of the invention is characterized by a presence, absence, relatively high or relatively low level of expression of one or more genes (e.g mRNAs) set forth in any one of Tables 9-12.
  • genes e.g mRNAs
  • microarray analysis of genes expressed in human cells of the invention has revealed that certain genes are expressed at higher or lower levels human cells compared to neurosphere-derived cells from which the cells were cultured. It is also evident that exposure to growth factors such as FGF-2, FGF9, leukaemia inhibitory factor (LIF), SCF, BMP-4 and/or TGF ⁇ 2 modulates gene expression in human cells.
  • isolated mammalian cells of the invention may be characterized by protein expression.
  • Protein expression can be determined using the techniques in the Examples herein and other standard protein chemistry and serology techniques such as western blotting, 2D gel electrophoresis (e.g. SDS-PAGE and isoelectric focussing), mass spectrometry, immunohistochemistry and immunofluorescence (e.g by flow cytometric analysis).
  • standard protein chemistry and serology techniques such as western blotting, 2D gel electrophoresis (e.g. SDS-PAGE and isoelectric focussing), mass spectrometry, immunohistochemistry and immunofluorescence (e.g by flow cytometric analysis).
  • the isolated mammalian cell expresses one or more of the proteins set forth in Table 6, or preferably the proteins expressed by at least 20% of isolated mammalian cells listed in Table 7 and/or wherein mean fluorescence is greater than 5000 units.
  • the proteins expressed by said isolated mammalian cell wherein mean fluorescence is greater than 18000 units include: CD13; CD16/32; CD23; CD34; CD28; CD38; CD40; CD45; CD61; CD69; CD95; CDl 17; CD122; CD124; CD201 and/or CD309.
  • the isolated mammalian cell expresses one or more of OCT-3/4, SOX2 , NANOG, KLF4, MVH, KIT and NESTIN.
  • OCT- 3/4 and SOX2 proteins appear to be less abundant than in a Reference cell such as an ES cell.
  • the isolated mammalian cell of the invention may include a label for detection of the cell.
  • GFP is one example.
  • the label may be passed on to subsequent generations so as to monitor the development and cellular fate of the progeny.
  • the isolated mammalian cell of the invention has a diameter of about 6 to 12 micron, preferably 8 to 10 micron and defines a spherical shape in suspension culture.
  • the diameter of the cell can be determined by microscopy or other standard methods in the art.
  • the adherent mammalian cell defines an elongated shape, with a morphology that resembles a fibrocyte or mesenchymal cell, with variable dimensions.
  • An isolated mammalian cell according to the invention may be provided, produced, cultured or obtained by any of a number of processes.
  • these processes do not require the use of embryonic tissues, nor do they require genetic manipulation or modification of cells or tissues.
  • an isolated mammalian cell according to the invention is provided by culturing the one or more cells or tissues in conditions for promoting cell proliferation and self renewal. These conditions prevent the cell from differentiating.
  • the isolated mammalian cell is provided by a process including culturing one or more cells or tissues in a medium containing factors for inducing plasticity and/or inhibiting differentiation and/or for inducing proliferation.
  • the sample is a sample of adult tissue, examples including bone marrow, central nervous system tissue, neural tissue, skin, gut, pancreas, muscle, brain, heart, adipose, olfactory mucosa or other mucosa or epithelia.
  • the tissue is olfactory mucosa.
  • olfactory mucosa Particularly preferred examples of olfactory mucosa and methods for isolation are discussed in the Examples below.
  • Isolated mammalian cells may be cultured "directly" from primary olfactory mucosa or from neurospheres or a neurosphere-like cellular mass which is derived from primary olfactory mucosa.
  • the isolated mammalian cell is provided by a process including culturing neurospheres or a neurosphere-like cellular mass in a medium containing factors for inducing plasticity and/or inhibiting differentiation and/or for inducing proliferation, thereby providing the isolated mammalian cell.
  • a “neurosphere” is generally known in the art as a heterogenous mixture of sometimes free floating cells generated by neural stem cells in vitro. Neurospheres are understood to form because daughter neural stem cells remain attached to their mothers through many rounds of cell division. They may also form by aggregation in which some aggregates are clonal whereas others are not.
  • a "neurosphere -like cellular mass” is generally understood as meaning a cellular mass that has the physical characteristics of a neurosphere. However the mass is generally not just derived from a neural stem cell.
  • a neurosphere is a heterogenous mass that contains multipotent cells (typically less than 0.5 - 1 % of total cells) plus proliferating progenation and precursom, plus differentiating progeny
  • neurosphere-like cellular mass Prior to the invention a neurosphere-like cellular mass was understood to be multipotent normally giving rise to neurons or glia, and not to contain pluripotent cells.
  • the neurosphere or neurosphere-like cellular mass is formed by the process discussed in Murrell et al. 2005 Dev. Dynamics 233: 496.
  • the cell is provided by a process including:
  • a medium containing factors for inducing plasticity and/or inhibiting differentiation and/or for inducing proliferation are described further herein.
  • the factors that are used in the cell culture are FGF2, FGF9, leukaemia inhibitory factor (LIF) and SCF or homologues thereof that retain the functional activity of these molecules.
  • SCF is provided in a form wherein it is attached to, or otherwise expressed by, a feeder layer of cells.
  • the cell obtained from the neurosphere or neurosphere-like cellular mass or tissue sample is cultured on a feeder layer and exposed to a gelatin coated surface. Examples of these culture conditions are described further herein.
  • the cell is provided by a process including the following steps:
  • the culture medium is POSE medium.
  • the cells are cultured in step (c) for greater than 7 days. More preferably, the cells are cultured for greater than 16 days.
  • the medium may further comprise one or more of TGF ⁇ 2 or BMP4.
  • the medium comprises FGF2, LIF, FGF9, SCF, TGF ⁇ 2 and BMP4.
  • FGF2, LIF, FGF9, SCF, TGF ⁇ 2 and BMP4 may be used.
  • feeder cells expressing SCF may support cell culture in the absence of any of the other factors.
  • the RNA and/or expressed protein is analysed for expression of genes that are required for pluripotency of cells.
  • the resulting gene expression profile can be compared to the PluriNet database to determine the genes expressed in common with those in the PluriNet database.
  • the analysis provides information in regard to the pluripotentiality of the cells by providing information in relation to the ability of cells to form teratomas and to undergo differentiation in culture along specific differentiation pathways.
  • isolated mammalian cells of the invention may be propagated and differentiated into one or more cells or tissues of interest. Differentiation may be facilitated by culture of isolated mammalian cells of the invention in suitable growth and/or differentiation factors, as are well known in the art.
  • suitable growth and/or differentiation factors include NGF, colony stimulating factors, EGF, FGF, VEGF, HGF, IGFs and the like.
  • isolated mammalian cells of the invention may be differentiated into particular cell or tissue types such as neural cells, glia, epithelial cells such as skin and corneal cells, bone marrow cells or more differentiated cell types of the lymphoid or myeloid lineages, hepatic cells, pancreatic islet cells, cardiomyocytes and other muscle cell types and endothelial cells such as vascular endothelium, although without limitation thereto.
  • isolated mammalian cells of the invention may be differentiated into cells or tissues known to be affected in a disease or disorder. Examples of such diseases are schizophrenia, Parkinson's disease, motor neurone disease, hereditary spastic paraplegia, MELAS mitochondrial mutational disorder and Alzheimer's disease.
  • differentiated cells and tissues may be useful for autologous or non-autologous cell or tissue transplantation for the treatment of a disease or condition responsive to such treatment.
  • these differentiated cells may be useful for identifying or screening compounds for a desired activity, such as by drug screening and identification, toxicology, pharmacological testing and the like.
  • the desired activity may biological, pharmacological or any other desired activity.
  • desired activities may include cell growth and/or differentiation activity, anti-tumour activity, pro- or anti-apoptotic activity, neuropharmacological activity; activity in regulation of metabolism; hormonal activity; gene regulatory activity; cell cycle regulation and immunoregulatory activity.
  • candidate drug ⁇ i.e. any suitable compound
  • candidate drug could be screened using these differentiated cells to test their toxicological or teratogenic effect.
  • isolated mammalian cells of the invention cells may be differentiated into corresponding normal cells.
  • a candidate drug or other compound may then be applied to the differentiated cells (i.e normal or non-cancerous) cells to determine which drugs or compounds that act on the cancer cell line, but not on normal cells.
  • the drug or other compound may be added to the cancer cell line and the differentiated cells to select a drug or compound and/or dose suitable for killing the cancer cell line, but not the normal cells.
  • isolated mammalian cells of the invention may be propagated and differentiated into a specific type of neuron (with a specific neurotransmitter profile) or glia and then drug effects and gene expression assessed. Differentiated cells may then be screened using nucleic acid expression profiling or protein expression profiling to identify nucleic acids or proteins that may be used to investigate a cause of the disorder or could be used for clinical diagnosis.
  • Nucleic acid and protein profiling is known in the art and may include methods such as an array, microarray and protein binding assays (e.g. ELISA and Western blot).
  • the arrays may be nucleic acid arrays or protein arrays.
  • a reference expression profile may be determined by profiling expression of a number of selected nucleic acids or proteins from one or more representative normal or diseased individuals (i.e. individuals having a disorder).
  • a particular reference expression profile may be correlated with normal or diseased condition.
  • isolated mammalian cells of the invention may be propagated from a patient presenting with a particular disease, such as those mentioned above, and a nucleic acid or protein expression profile determined. This patient expression profile may be compared with a reference expression profile of an unaffected control. Such a comparison may determine a nucleic acid or protein profile correlated with a particular disease.
  • a reference expression profile of a diseased condition may be determined once an expression profile is known that correlates with a diseased condition.
  • nucleic acid or protein expression of these differentiated cells may then be compared with a reference expression profile, e.g. a control or known profile correlated with a diseased condition.
  • Comparing an expression profile of a diseased condition with a normal control may reveal a biochemical pathway associated with the diseased condition. Such a finding may lead to a diagnostic test for that disease and may aid in defining a cause of the disease.
  • the reference nucleic acid or protein expression profile may comprise a variety of cell types or tissue types.
  • the reference profiles may be purchased commercially.
  • a reference profile may comprise a "control sample" from normal tissues of developmental stages of interest, such as those available commercially or the control sample may originate from cells of a particular disorder.
  • schizophrenia a change in gene expression is observed in post- mortem brain.
  • a similar change in gene expression may be assessed in cells available from a skin biopsy.
  • a comparison may be made between fibroblast cell from skin, olfactory tissue biopsies and isolated and propagated olfactory stem cells. All these samples may be compared with commercially available reference profile (s) or a unique reference profile may be discovered which may be compared with future samples for research or diagnostic purposes.
  • the isolated mammalian cells of the invention When assessing genetic fingerprints of disease it may not be necessary to differentiate the isolated mammalian cells of the invention uniformly into a specific cell type and a heterogeneous population of neurons and glia that are reproducibly presented in control and disease cultures may be sufficient to compare gene expression. Alternatively, if a particular neuron type is suspected to be affected in a disease the isolated mammalian cells may be differentiated into a single cell type.
  • the method described above does not require assaying for a previously known nucleic acid or protein.
  • a comparison between expressed nucleic acids or proteins of a test cell and a known normal and/or diseased cell may provide information in relation to the test cell being normal or diseased (i. e. associated with a disorder).
  • Toxicity or teratogenicity of a compound may be determined by abnormal or a change in behavior of the isolated mammalian cell and/or differentiated cell therefrom.
  • abnormal or changed behaviour may include a change when compared with control non-disease cultures or control non-compound exposed cultures.
  • Such changes include: cell death rate, cell division rate, proliferation rate, differentiation fate or abnormal differentiation, a change in morphology (perhaps due to cytoskeletal deficits), a changes in nuclear repair mechanisms such as in response to ionising radiation or a change in gene expression or protein expression.
  • a person skilled in the art would be able to consider other changes in cell behaviour.
  • an isolated mammalian cell of the invention or a cell differentiated therefrom as hereinbefore described, transformed or transfected with an isolated nucleic acid, referred to herein as a "genetically- modified cell of the invention".
  • the isolated nucleic acid encodes a therapeutic agent, such as a therapeutic protein or therapeutic nucleic acid.
  • therapeutic nucleic acids include RNA molecules, as wil be described in more detail hereinafter.
  • the isolated nucleic acid is, or is provided in, a genetic construct, such as an expression vector or construct.
  • the genetic construct comprises said isolated nucleic acid operably linked or connected to one or more additional nucleotide sequences.
  • additional nucleotide sequences may be regulatory sequences that facilitate and/or control expression of said nucleic acid.
  • Non-limiting examples include promoters, enhancers, repressors, polyadenylation sequences, introns and/or splice donor/acceptor sequences, although without limitation thereto.
  • the promoter may be constitutive, regulatable (Le inducible or repressible), tissue specific or subject to other desired functional constraints or influences on promoter activity.
  • the promoter may be any promoter useful for mammalian expression, including but not limited to a CMV promoter, an SV40 promoter, an elongation factor ⁇ promoter (e.g. pEF-BOS), a crystallin promoter (e.g. ⁇ A crystallin, ⁇ 2 crystallin) or a hybrid promoter (e.g. SRa), for example.
  • additional nucleotide sequences may be selection marker sequences to facilitate selection of stable transformants/transfectants (e.g by providing resistance to neomycin, geneticin etc., or susceptibility to gangcyclovir, for example).
  • additional nucleotide sequences may include sequences that facilitate homologous recombination, inclusive of gene "knock out” or “knock in” sequences such as Cre, loxP and/or FLP recombinase sequences.
  • Isolated mammalian cells of the invention, or differentiated cells may be transfected or transformed with a genetic construct, such as an expression vector or construct comprising a nucleic acid of interest.
  • any suitable means for delivering a nucleic acid into a cell may be used, for example transfection or transformation such as by electroporation, calcium phosphate precipitation, cationic lipid delivery, DEAE dextran or other methods known in the art.
  • the construct or vector may be integrated into the genome of the isolated mammalian cell, or alternatively may be maintained extra-chromosomally.
  • the nucleic acid may encode a protein or another molecule such as an RNA molecule, such as a therapeutic protein or RNA (e.g. an interfering RNA, microRNA, snoRNA, piRNA, ncRNA or a ribozyme). These RNA molecules may have a role in cellular activities including tumour suppression, regulation of transcription and/or of translation and/or regulation of the cell cycle, or of regulation of apoptosis.
  • Proteins encoded by the nucleic acid may be hormones, cytokines, growth factors, neurotransmitters, enzymes, antibodies, immunogenic and/or antigenic proteins, although without limitation thereto.
  • the protein may be a gene regulatory protein such as a transcription factor, repressor or other DNA-binding protein, or a protein that induces epigenetic changes in chromatin structure. Examples include but are not restricted to: histone modifiers (acetylases, deacetylases, DNA methyltransferases).
  • the nucleic acid may correspond to an "endogenous nucleic acid" normally expressed by the cell, or a fragment thereof, or may be homologous to an endogenous nucleic acid.
  • the construct or vector may comprise an endogenous nucleic acid that corresponds to a defective or mutated nucleic acid of a recipient. Accordingly, expression of the nucleic acid and/or encoded protein may treat a disease present in the recipient caused by the mutated or otherwise defective endogenous nucleic acid of the recipient.
  • Genetically modified cells of the invention may be suitable for delivering therapeutic agents to a mammal to thereby treat a disease or condition.
  • the nucleic acid may enable said genetically modified cell of the invention to express a secreted protein such as a hormone, growth factor or cytokine, or biologically active fragment thereof.
  • a secreted protein such as a hormone, growth factor or cytokine, or biologically active fragment thereof.
  • Expression of these proteins may have therapeutic benefit.
  • these proteins include: insulin for treating diabetes; thyroxine for treating hypothyroidism; and/or treatment of the nervous system such as by expressing dopamine or GDNF for Parkinson's Disease or acetylcholine to treat Alzheimer disease.
  • other growth factors might be useful such as BDNF, NGF, NT3.
  • the invention provides compositions, methods and/or uses of one or more isolated mammalian cell according to the invention, and/or one or more cells differentiated therefrom, for treating a disease or condition in a mammal.
  • Such treatments may be prophylactic or therapeutic, as required.
  • compositions of the invention may comprise one or more of said cells together with a carrier, diluent, excipient or preservative.
  • the composition is a pharmaceutical composition.
  • the pharmaceutical composition suitably comprises a pharmaceutically-acceptable carrier, diluent or excipient.
  • pharmaceutically-acceptable carrier, diluent or excipient is meant a solid or liquid filler, medium, diluent or encapsulating substance that may be safely administered to a mammal, such as a human-
  • carriers may be selected from a group including sugars, starches, phosphate buffered solutions, emulsifiers and isotonic saline.
  • any suitable route of administration may be employed for providing a patient with the pharmaceutical composition of the invention.
  • intravenous, intra-articular, intra-muscular, intra-dermal, subcutaneous, intraperitoneal, surgically implanted and the like may be employed.
  • the pharmaceutical composition is administrable to a specific site by surgical implantation.
  • Non-limiting examples include compositions administrable at a site of a spinal injury, as bone marrow for reconstitution in immune compromised patients, as heart muscle for regeneration in cardiac patients, as pancreatic ⁇ cells for diabetics, or as neural tissue for treating brain injury or degeneration.
  • cells may be administered into either the caudate nucleus or the substantia nigra for dopamine neuron replacement in treating Parkinson's disease patients.
  • a predetermined dosage form includes dispersions, suspensions, injections, solutions and the like. Dosage forms may also include implants, matrices, microcapsules, prostheses, gels, controlled-delivery devices, osmotic pumps and the like.
  • Pharmaceutical compositions of the present invention suitable for administration may be presented as discrete units such as vials containing a predetermined amount of one or more cells of the invention, as a solution or a suspension in an aqueous liquid or a non-aqueous liquid. Such compositions may be prepared by any of the methods of pharmacy, but all methods include the step of bringing into association one or more cells as described above with the carrier which constitutes one or more necessary ingredients.
  • stem cells obtained from a biopsy of human donor having the CCR5 allele may confer resistance to HIV infection (Samson et al., 1996, Nature 382 722, incorporated herein by reference).
  • Cells may be transplanted into a patient infected with HIV to prevent or reduce progression of AIDS.
  • cells may be transplanted into a non-infected patient to confer immunity or resistance to HIV infection.
  • Similar methods may be used to genetically modify a cell propagated in accordance with the methods of the invention such that the propagated cells express any nucleic acid of interest.
  • diseases may potentially be treated, for example, nerve injury, spinal injury, schizophrenia, Parkinson's disease, Alzheimer's disease, bipolar disorder, mitochondrial disorders, epilepsy, diabetes, kidney failure, neuro-degenerative diseases, plastic anemia, immune-deficiency diseases, autoimmune diseases, cancers including lymphomas and leukemias, sickle cell anemia and osteoporosis deficiency in expression of a protein.
  • the cells of the invention may be useful for treating genetic defects.
  • U. S. Pat. No. 5,760, 012 (incorporated herein by reference) describes methods to genetically modify hematopoietic stem cells in patients afflicted with hemoglobinopathies such as sickle cell anemia, beta-thalassemia, or Gaucher's Disease. Methods of treating sickle cell anemia are disclosed by Cole-Strauss, A., et al., 1996, Science, 273 1386, incorporated herein by reference.
  • genetically modified cells of the invention may express an antibody or an antigen.
  • the genetically modified cell of the invention may be differentiated into a "dendritic cell" (DC) for use in dendritic cell therapy.
  • DC dendritic cell
  • DCs are antigen presenting cells capable of initiating an antigen-specific T- cell response in an animal.
  • DCs may be isolated from various locations of an animal's body, including peripheral blood, however, it may be difficult and laborious to isolate and propagate DCs from blood.
  • DC precursors may be propagated.
  • a DC precursor may be propagated and expanded in accordance with the methods of the present invention so that a suitable number of cells may be cultured for use in dendritic cell therapy.
  • a isolated mammalian cell may be differentiated into a predetermined stage of development suitable for dendritic cell therapy.
  • Dendritic cell therapy refers to therapeutic cancer vaccines or cellular vaccines used for tumour immunotherapy as a method for treating cancer. Dendritic cell therapy typically involves isolating DC from a patient (or isolating propagating the DC precursor), culturing the isolated DC in the presence of a tumour-associated antigen or transfecting the isolated DC with a nucleic acid encoding a tumour- associated antigen ("antigen loading or pulsing"), and administering the antigen loaded or transfected DCs to the patient.
  • US Patent 5,788, 963 describes methods and compositions for use of human dendritic cells to activate T-cells for immunotherapeutic responses against primary and metastatic prostate cancer.
  • isolated DC are exposed in vitro to a prostate cancer antigen before administration to a patient.
  • Isolated mammalian cells may be used with a patient undergoing high dose chemotherapy and/or radiation therapy.
  • a neural tissue biopsy may be performed on a patient and the stem cells expanded in vitro in accordance with the invention and stored.
  • the stem cells may be genetically modified or not after biopsy.
  • the cells may later be infused into the patient after the chemotherapy treatment.
  • Isolated mammalian cells of the invention may undergo spontaneous or induced immortalisation in vitro.
  • the resulting immortalised, clonal or non-clonal cells may be useful as a cell line that may be genetically manipulated or not.
  • the cell line may be placed in conditions that induce or do not induce, lineage commitment in vitro or in vivo and/or undergo cell differentiation or not, in vitro or in vivo.
  • Isolated mammalian cells of the invention can be used for basic research to understand the fundamental biology of development, including genes, growth factors and nutrients, which direct cellular and tissue formation. Examples of typical methods that may be used with cells prepared in accordance with the present invention are well known in the art.
  • one particular aspect of the invention provides a method of producing a non-human mammal, said method including the steps of:
  • the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
  • the method further includes the step of implanting or otherwise transferring the blastocyst produced at step (i) to a female non-human mammal.
  • the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
  • progeny include and encompass immediate offspring and the progeny of subsequent generations.
  • One particular embodiment includes producing a genetically-modified non- human mammal.
  • one or more genetically-modified mammalian cells as hereinbefore described, may be delivered to the blastocyst of the non-human mammal at step (i).
  • Subsequent "transgenic" progeny may be bred which include the genetic modification of the cell delivered at step (i).
  • a non-human mammal e.g. a mouse or rat
  • a non-human mammal produced according to the invention, inclusive of genetically-modified non-human mammals, may be useful for drug screening, analysis of developmental gene expression and identification of candidate molecules having a desired biological activity, such as by high-throughput screening, although without limitation thereto.
  • the desired biological activity may include cell growth and/or differentiation, anti-tumour activity, pro- or anti-apoptotic activity, cell cycle regulation and immunoregulatory activity, although without limitation thereto.
  • Isolated mammalian cells of the invention may be used with a known animal model of disease to assess cell replacement therapy.
  • animal models include: (A) neurobiology and disorders thereof, in all of its manifestations, including: Alzheimer's disease, Amyotrophic lateral sclerosis, Huntington's disease research tools for neurobiology, spinal cord injury, spinal cord disease, multiple sclerosis, cerebral palsy, muscular atrophy, (B) cardiovascular biology and disorders thereof, in all of its manifestations including myocardial infarction, stroke, ischemia, (C) epilepsy in all of its manifestations, (D) reproduction and disorders thereof, in all of its manifestations, (E) endocrinology and disorders thereof, in all of its manifestations, including Diabetes Mellitus Type I and Type II, (F) sensorineural development and function and disorders thereof, in all of its manifestations, (G) immune deficiency in all of its manifestations, (L) inflammation in all of its manifestations, (H) vital organ development and function and disorders thereof, in all of its manifestations, (I) dermatology and disorders thereof in all of its manifestations, (J) lung and respiratory tract development and function and disorders thereof,
  • Olfactory mucosa was dissected from adult, transgenic Rosa-EGFP mice (Quah et al., 2008, Proceedings of the National Academy of Sciences of the United States of America 105, 4259) and the cells grown in serum-free medium with EGF and FGF2 to form neurospheres in order to select for a cell population that includes a multipotent, neural stem cell (Murrell et al, 2005, Dev Dyn 233, 496; Murrell et al, 2008, Stem cells (Dayton, Ohio) 26, 2183)
  • Neurosphere-derived cells were dissociated and grown on a feeder layer of mouse stromal cells expressing a membrane-associated form of mouse Stem Cell Factor (SCF; Matsui et al., 1992, Cell 70 841) in a medium containing FGF2, SCF, FGF9, and Leukemia Inhibitory Factor (LIF).
  • SCF Stem Cell Factor
  • FGF9 FGF9
  • LIF Leukemia Inhibitory Factor
  • EGFP-dim and EGFP-negative cells were selected for blastocyst injection; some were frozen and stored beforehand (Fig. IG).
  • the EGFP-bright cells were of mixed, more complex morphologies and were not selected for blastocyst injection.
  • chimeric mice from pOS cells and of Fl from chimerics pOS cells were injected into syngeneic C57BL/6 blastocysts (3.5 d.p.c.) which were then implanted in pseudo-pregnant CD-I females.
  • Chimeric embryos and neonates were identified by the presence in their tissues of the EGFP transgene identified using qPCR or PCR of DNA from tissue samples of tail, limb-bud or liver (Fig. IE, F; Supplementary Fig. 1).
  • Chimeric mice were generated in 5 out of 6 series of blastocyst injections (Fig. IG).
  • EGFP-dim cells were selected and 15-18 or 20-25 cells were injected into each blastocyst.
  • a new population of pOS cells was generated from a second culture preparation. This time, culturing for an extra week produced EGFP-negative pOS cells (Fig. IB-D), 15-18 of which were injected per blastocyst, producing 39 offspring; 22 were chimeric (Fig. IG). pOS cells were able to be frozen and thawed. The proportion of chimeras was similar whether the pOS cells were taken from fresh cultures or thawed from frozen aliquots of those same cultures (Fig. IG). Taken together these results demonstrate that the pOS cells robustly and repeatedly gave rise to chimeric mice after blastocyst injection. Significantly, we demonstrated germline chimerism in 5 of these chimeras of both sexes and demonstrated passage of the EGFP transgene through two subsequent generations.
  • Fig. IG blastocysts with single pOS cells
  • Fig. IG single pOS cells
  • the tissues of chimeric animals were demonstrably chimeric for the EGFP transgene identified immunochemically at 13.5 d.p.c.
  • Organs from all embryonic germ layers were EGFP-positive in some embryos (Fig. 2A-C; Fig. 5).
  • the developmental potency of stem cells is often evaluated by their ability to form teratomas when injected into immune deficient mice.
  • Pluripotency demonstrated by teratoma formation is taken as a marker for pluripotency (Okita et al., 2007, Nature 448 313; Takahashi et al., 2007, Cell 131 861; Thomson et al, 1998, Science 282 1145).
  • the injected pOS cells were from the same batch that produced chimeric mice. None of the 6 injection sites showed any tumours or teratomas during the 4 month period of observation. Independent veterinary post-mortem and pathological inspection revealed no tumours in any part of the body.
  • ES cells embryonic stem cells
  • ES cells embryonic stem cells
  • iPS cells induced pluripotent stem cells
  • pOS cells Preliminary analysis of pOS cells indicated that they did not express Oc ⁇ /4 or Sox2, although they robustly expressed Myc and Klf4 and only very low levels of Nanog (Fig. 6). It was therefore of interest to compare the transcriptome of pOS cells with other pluripotent cells, to seek a deeper understanding to the lack of expression of such "essential" pluripotency genes as Oct3/4 and Sox2( Kim et al., 2008, Nature 454 646). Whole transcriptome analysis was undertaken to compare cells at different stages of pOS cell generation: neurosphere-derived cells (Reference cells), EGFP- dim and EGFP-bright (FACS selected but not injected). Overall, the EGFP-bright cells were more similar in gene expression to the Reference cells, with an increasing trend to homogeneity of expression in EGFP-dim and EGFP-negative pOS cells (Fig. 3A).
  • the gene expression analysis confirmed the preliminary qPCR analysis in detecting mRNAs for Klf4 and Myc, but not Oct3/4 and Sox2, genes thought central for pluripotency in iPS cells (Kim et al., 2008, supra). Nanog mRNA was detected at low levels in EGFP-dim pOS cells but not in EGFP-negative pOS cells. Notably, OCT-3/4, SOX2 and NANOG proteins were detected in vitro by immunofluroescence in some clusters of pOS cells (Fig. 3C), indicating that a minority of cells (10%) retained these proteins while their mRNA was undetectable in the pOS cell population (Fig. 3C).
  • Murine pOS Cell culture Olfactory neurosphere cultures were prepared from olfactory mucosa
  • Neurospheres were grown for 7-8 d in a serum-free medium containing EGF and FGF2 then harvested by trypsin digestion and grown for a further 2 d as single cells. They were then dissociated and plated in flasks, pre-coated with a solution gelatin, and seeded with a confluent monolayer of freshly-thawed, immortalised, S7/S74-mSCF220 mouse stromal cells that were mitotically inactivated. The cells were grown at 37C and 5% CO 2 in humidified air in pOS enrichment (POSE) medium.
  • PES pOS enrichment
  • the cells were harvested by trypsin digestion and grown for 2 passages on gelatin-coated flasks without feeders, and harvested at 70-80% confluence by trypsin digestion. Trypsin was inactivated by the addition of surplus POSE medium.
  • pOS cells were analysed and sorted using a BD FACSVantage SE DiVa Cell Sorter according to levels of EGFP fluorescence.
  • Blastocysts were harvested at 3.5 days post coitus (dpc) after mating wild type, adult C57BL/6J females and males.
  • Single or multiple GFP-dim or GFP- negative populations of pOS cells, selected by FACS were injected into blastocysts after which they were placed within the oviduct (0.5 dpc,) or the anterior uterine horn (2.5 dpc) of pseudopregnant CD-I female mice, that were mated with vasectomised CD-I males (Nagy et ah, Manipulating the mouse embryo: a laboratory manual, 3rd ed. (Cold spring Harbor Laboratory Press, Cold Spring Harbor, 2003)).
  • Chimerism was detected in embryos harvested at 13.5 or 16.5 dpc and in neonatal pups by analysing DNA from tail, foetal liver or limb bud tissue, using quantitative, real-time polymerase chain reaction (qPCR). Some chimeric pups were grown to adulthood and mated with adult C57BL/6J mice to test for germ-line transmission of the EGFP transgene to produce transgenic offspring. These were identified by detection of EGFP using qPCR genotyping. Chimeric and transgenic embryos were also analysed for EGFP protein expression using immunofluorescence.
  • qPCR quantitative, real-time polymerase chain reaction
  • mice were adult male Rosa-EGFP Tg (EGFP-Tg) mice, 15 weeks old. The mice were generated by crossing a Rosa26 stop/flox-EGFP mouse (kindly provided by Martyn Goulding, Department of Neurobiology, SaIk Institute, University of California at San Diego, La Jolla, CA) with a generalized Cre recombinase-expressing mouse TNAP Cre, to activate expression of EGFP (Clarke et al., 2000, Science 288 1660). Blastocysts were obtained from naturally-mated adult female C57B16J mice, 7-12 weeks of age.
  • mice Outbred wild type CD-I, inbred, wild type C57BL/6J and immune deficient NOD.CB 11-Prkdc scid mice were purchased from the Animal Resources Centre, Canning Vale, Western Australia. All mice were maintained in specific pathogen free barrier conditions at all times. All experiments were performed with approval of the Animal Ethics Committees of Griffith University and the University of Queensland in accordance with the guidelines and recommendations of the National Health and Medical Research Council of Australia.
  • mice were killed with CO 2 and olfactory neurosphere cultures were prepared as described previously (Murrell et al., 2005, Dev Dyn 233, 496).
  • the olfactory mucosa was removed from the nasal septum and placed in ice cold Dulbecco's modified Eagle's medium /HAM F12 (DMEM/F12 ; GIBCO- Invitrogen) supplemented with 10% Foetal Bovine Serum (Bovogen, Australia) and 50 U/ml penicillin and 50 ⁇ g/ml streptomycin (GIBCO-Invitrogen).
  • HBSS Hank's buffered salt solution
  • Dispase II 2.5U/ml
  • the olfactory epithelium was isolated from lamina intestinal under the dissection microscope and both tissues were washed separately in HBSS.
  • the lamina propria was further digested with Collagenase I (Sigma- Aldrich) for 10 minutes and gently triturated.
  • the cells were washed with HBSS. In the mean time, the olfactory epithelium was gently triturated to break sheets of tissue into cells and washed with HBSS.
  • the cell pellets resuspended in DMEM/F12 supplement with 10% FBS and 50U/ml Penicillin and 50 ⁇ g/ml streptomycin and cultured together in a 6-well tissue culture plate (Nunc) in 5% CO 2 at 37°C.
  • the cells were passaged using 0.25% trypsin n 0.02% EDTA (GIBCO-Invitrogen) and seeded onto poly-L-lysine (0.85 ⁇ g/cm 2 ; Sigma) coated 6-well tissue culture plates (Nunc) in DMEM/F12 supplemented with Insulin, Transferrin and Sodium Selenite (ITS; GIBCO- Invitrogen), 50 ng/ml Epidermal Growth Factor (EGF; Chemicon) and 25 ng/ml Fibroblast Growth Factor 2 (FGF2; Chemicon) to generate neurospheres. After 7-8 days, the neurospheres were collected.
  • Cell clumps were disaggregated by gentle, repeated pipetting. Cell suspensions were transferred to polypropylene tubes and centrifuged (1,000 x g; 5 mins; 4C). Medium was aspirated. Cell pellets were dislodged by gently tapping the tubes. Cells were resuspended in fresh POSE medium and plated at 40% - 50% confluence in ventilated tissue culture-grade flasks, pre-coated with a solution of 0.1% (w/v) gelatin type A (Sigma- Aldrich), and seeded with a confluent monolayer of freshly-thawed, immortalised, Sl/Sl 4-mSCF220 mouse stromal cells (a kind gift from Prof. B.
  • pOS cells were pre-plated onto gelatin without feeders for 2 passages. Short-term culture without feeders did not appear to compromise pluripotency, as indicated by FACS, microarray, and qPCR data.
  • Cells were resuspended in 0.5 mL - 1 mL PBS/2% FBS and maintained on ice when not in use. Cells were analysed and sorted using a BD FACSVantage SE DiVa Cell Sorter. EGFP fluorescence was detected using a Coherent Innova 7OC argon laser at 488 nm wavelength.
  • Blastocysts were transferred to a dish containing KSOM-AA medium (Specialty Media) and incubated for 2-3 hrs (37C; 5% CO2 in humidified air). Immediately before microinjection into blastocysts, pOS cells were harvested and FACS-sorted. EGFP-dim or EGFP-negative populations were collected in PBS/2% FBS, washed, resuspended in POSE medium and placed on ice prior to blastocyst injection.
  • Blastocysts were removed from the incubator, transferred to a dish containing FHM medium and pOS cells. The dish was placed on a cooling stage set to 14C attached to a DM-IRB inverted microscope (Leica) fitted with DIC objectives and microinjectors (Narishige). Single or multiple pOS cells were injected into each blastocyst, as described elsewhere. Following microinjection, blastocysts were washed through KSOM medium and incubated in KSOM medium (37C ; 5% CO2 in humidified air) for 1 hr or until blastocysts re-expanded.
  • KSOM medium 37C ; 5% CO2 in humidified air
  • Tail, foetal liver or limb bud tissue was digested in a solution containing 50 mM Tris-HCl (pH 7.6) (Sigma- Aldrich), 100 mM Na 2 EDTA (Sigma- Aldrich), 100 mM NaCl (Sigma- Aldrich), 1% (w/v) sodium dodecyl sulfate (Sigma- Aldrich) and 0.4 mg Proteinase K (Roche) / mL. Tissue was incubated at 55C for 16 hours. Genomic DNA was then extracted by the addition of 0.5 vol. of Tris-buffered phenol (Fluka) biopsies plus 0.5 vol.
  • Tris-HCl pH 7.6
  • Tris-HCl 100 mM Na 2 EDTA
  • 100 mM NaCl Sigma- Aldrich
  • 1% (w/v) sodium dodecyl sulfate Sigma- Aldrich
  • Proteinase K Roche
  • chloroform :isoamyl alcohol (24:1) (Fluka).
  • the organic and aqueous phases were mixed thoroughly by inversion, then centrifuged (12,000 x g; 15 mins; room temp.).
  • An equal volume of chloroform:isoamyl alcohol (24:1) was added to the aqueous solution, mixed by inversion, and centrifuged as before.
  • the upper, aqueous phase was transferred to a clean tube and residual isoamyl alcohol allowed to evaporate.
  • An equal volume of isopropanol was added to each tube, shaken thoroughly, and centrifuged (12,000 x g; 20 mins; room temp.).
  • EGFP FP 5'CTGAGCAAAGACCCCAACGAS' SEQ ID NO:3
  • EGFP RP 5'TCGTCCATGCCGAGAGTGA3 1 SEQ ID NO:4
  • Reactions were performed in 25 uL volumes, in the following conditions: Stage 1: 50C; 2 mins (1 cycle); Stage 2: 95C; 10 mins (1 cycle); Stage 3: 95C; 15 sees; 6OC; 1 min (40 cycles).
  • Reactions contained 5 uL genomic DNA, diluted 1:10 in 10 mM Tris (pH 7.6): 1 mM EDTA, 0.15 uM forward and reverse primers, Ix SYBR Green PCR Mastermix (Applied Biosystems). Volumes were adjusted to 25 uL with MiIIiQ water. For each primer pair, a "no template" control reaction was included, as a test of primer specificity and to ensure the water was not contaminated with gDNA.
  • QPCR reactions were undertaken in 96-well plates, in an ABI Prism Detection System 7000 plate reader. Analyses were performed using ABI Prism SDS software (Applied Biosystems).
  • Non-denaturing polyacrylamide gel electrophoresis QPCR amplicons were electrophoresed through a 12% non-denaturing polyacrylamide gel, prepared according to Sambrook et al. Molecular Cloning: A Laboratory Manual 2 nd Ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989).
  • FACS-sorted pOS (GFP negative) and GFP-bright cells were each resuspended in sterile PBS at a concentration of 10 6 cells/mL.
  • 0.1 mL (10 5 ) pOS cells was injected subcutaneously at the right shoulder and hip of 3 male NOD/SCID mie (5 wks of age), The same mice were injected at the contralateral sites with 0.1 mL PBS.
  • a second group of 3 NOD/SCID males (5 wks of age) was injected s.c. at the right shoulder and hip with 0.1 mL (3 x 10 3 ) GFP-bright cells, and with 0.1 mL PBS at the contralateral sites.
  • Mice were maintained for 4 months, then euthanased prior to full histopathological analysis by an independent veterinary pathologist (Institute for Medical and Veterinary Science, Sydney, S.A.).
  • Pregnant females (12.5-16.5 dpc) were euthanased by cervical dislocation.
  • Foetuses were resected and placed in pre-chilled petri dishes containing sterile PBS, maintained on ice.
  • Foetuses were euthanased by hypothermia.
  • Foetuses were transferred to a dissecting microscope, to remove extra-embryonic structures.
  • a small piece of tissue e.g. tail or hindlimb was removed from each foetus for DNA extraction and determination of genotype.
  • Whole foetuses were fixed in Bouin's solution (Sigma- Aldrich) and incubated on a rocking platform at room temperature for 24 hrs.
  • Foetuses were processed overnight (Leica tissue processor), and embedded in Paraplast Extra embedding wax (Lomb Scientific). 7-10 um thickness saggital sections (Jung Biocut 2035 microtome (Leica)) were dried onto Menzel-Glaser SuperfrostTM Plus glass microscope slides (Lomb Scientific) and dried at room temperature.
  • Immunofluorescent detection of EGFP Sections were immersed in two changes of xylene (20 mins each; room temp.), then rehydrated through an ethanol series (100%, 100%, 95%, 80%, 70%, 50%, 30%), and finally, through two changes of MiIIiQ water. Sections were immersed in each solution for 3 mins and then in antigen unmasking solution (Vector Laboratories H-3300), prepared according to the manufacturer's instruction and brought to boiling point immediately before slides were boiled for a further 5 mins in a microwave.
  • antigen unmasking solution Vector Laboratories H-3300
  • Slides were sealed within a humidified chamber and incubated overnight at 4C. Slides were drained, immersed in PBTX, blocked for 30 mins at room temp., then overlaid with an Alexa 488-goat anti-rabbit IgG H+L secondary antibody (Invitrogen Al 1008), diluted 1:200 in blocking solution. Slides were sealed within a light-resistant humidified chamber and incubated at room temp, for 1 hr. Slides were rinsed with PBTX, and overlaid with DAPI (4'-6'-Diamidino-2- phenylindole dihydrochloride (2.5 ng/mL) (Sigma-Aldrich)), for 5 mins at room temp, in a light-resistant, humidified chamber.
  • DAPI 4'-6'-Diamidino-2- phenylindole dihydrochloride (2.5 ng/mL) (Sigma-Aldrich)
  • Slides were rinsed with PBTX, mounted with 70% (v/v) glycerol: 30% (v/v) PBS, and sealed with coverslips. Slides were stored at 4C in the dark when not in use. Sections were photographed using either an Olympus BX-51 fluorescent microscope with DP Controller and DP Manager imaging software or an Olympus FVlOOO Confocal Microscope system. Figures were compiled in Adobe Photoshop 7.0 and Adobe Illustrator 10.0 (Adobe Systems Incorporated).
  • a "no template" control reaction was included, as a test of primer specificity and to ensure the water was not contaminated with cDNA.
  • forward and reverse primers were designed to span an intron. 18SrRNA 5' GATCC ATTGGAGGGCAAGTCT3' (SEQ ID NO:5) 18S rRNA 3' CCAAGATCCAACTACGAGCTTTT ⁇ 1 (SEQ ID NO:6)
  • Oct-3/4 FP 5 1 TGCGGAGGGATGGCATACTG3' (SEQ ID NO:7)
  • Oct-3/4 RP 5' GCACAGGGCTCAGAGGAGGTTCS' (SEQ ID NO:8)
  • Stra8 RP 5 1 GCAGGTTGAAGGATGCTTTGAGCS' (SEQ ID NO: 10)
  • Nanog FP 5' AGCCTCC AGC AGATGC AA3' (SEQ ID NO: 19)
  • Nanog RP 5' GGTTTTGAAACCAGGTCTTAACC3' (SEQ ID NO:20)
  • Klf4 FP 5' CGGGAAGGGAGAAGACACTS' SEQ ID NO:23
  • Klf4 RP 5' GAGTTCCTCACGCCAACG3' (SEQ ID NO:24)
  • the specimens were rinsed in PBS triton (0.1 M PBS and 0.1% Triton-X-100 [TX-IOO]) and permeabilised in DMSO (100%) for 10 minutes, then rinsed in PBS triton for 5 min before being blocked with 10% donkey serum (Sigma Chemical Corporation)) in PBS triton. DMSO was omitted for cell-surface immunostaining.
  • the specimens were incubated with primary antibodies diluted in block buffer over night, at room temperature. The primary antibodies used in single and multiple labelling are listed in Table 1. The specimens were incubated for 30 minutes in block buffer before being incubated for 3 hours with the secondary antibodies diluted in block buffer, followed by washing.
  • the secondary antibodies were donkey anti- rabbit, anti-goat or anti-mouse antibodies (Invitrogen) conjugated with Alexa-488 (green), 594 (red), or 647 (far red).
  • the coverslips with adherent cells were mounted on glass slides using Vectashield DAPI (4'6-diamidino-2-phenylindole-2HCl, Vector Labs) mounting media which labels cell nuclei. No cross-reactivity occurred between the primary and secondary antisera combinations. Control experiments showed omission of either primary antisera abolished visible labelling with the appropriate secondary antibody/fluorophore combination.
  • the specimens were imaged on an Axio Imager Zl epi-fluorescence microscope using 1OX and 2OX Plan-Apochromatic objectives and an oil immersion 63X Plan-Apochromatic objective. Images were captured on an Axiocam Mrm camera using Axio Vision software. Figures were compiled in Adobe Photoshop 7.0 and Adobe Illustrator 10.0 (Adobe Systems Incorporated).
  • POSE culture medium is replaced daily. Cells are passaged every 2 - 3 days and seeded into sterile flasks, pre-coated with gelatin and seeded with freshly-thawed, mitotically-inactivated feeders. The cells may be passaged up to 10 times or more without loss of developmental potency.
  • Cryopreservation of pOS cells pOS cells are harvested by trypsin digestion (3 mins; 37C; 5% CO2 in humidified air). Trypsin is inactivated by the addition of surplus pOS cell enrichment medium. The cell suspension is transferred to polypropylene centrifuge tubes. Cells are pelleted (1,000 x g; 5-8 mins; 4C or room temp). The supernatant is aspirated and discarded. Cells are resuspended in 90% (v/v) FBS; 10% (v/v) cell culture-tested DMSO, dispensed into cryovials. The cryovials are placed on dry ice for 15 mins then stored for 24 hrs at -80C before transfer to LN2 (preferably vapour phase) for long-term storage.
  • LN2 preferably vapour phase
  • pOS cells are removed from the LN2 source and placed on dry ice. Cells are then thawed rapidly by immersion of the cryovial in a 37C waterbath. The cell suspension is diluted in surplus pOS cell enrichment medium and centrifuged (1,000 x g; 5-8 mins; 4C or room temp). The supernatant is aspirated and discarded. The cell pellet is resusupended gently in fresh pOS cell enrichment medium then plated into TC-grade plastic, pre-coated with gelatin and containing a confluent monolayer of feeders. EXAMPLE 2 Further characterization of murine pOS cells
  • mice were killed with CO2 and olfactory neurosphere cultures were prepared as described previously (Murrell et al., 2005, Dev Dyn 233, 496).
  • the olfactory mucosa was removed from the nasal septum and placed in ice cold Dulbecco's modified Eagle's medium /HAM F12 (DMEM/F12 ; GIBCO- Invitrogen) supplemented with 10% Foetal Bovine Serum (Bovogen, Australia) and 50 U/ml penicillin and 50 ⁇ g/ml streptomycin (GIBCO- Invitrogen).
  • HBSS Hank's buffered salt solution
  • Dispase II 2.5U/ml
  • the olfactory epithelium was isolated from lamina intestinal under the dissection microscope and both tissues were washed separately in HBSS.
  • the lamina propria was further digested with Collagenase I (Sigma- Aldrich) for 10 minutes and gently triturated.
  • the cells were washed with HBSS. In the mean time, the olfactory epithelium was gently triturated to break sheets of tissue into cells and washed with HBSS.
  • the cell pellets resuspended in DMEM/F12 supplement with 10% FBS and 50U/ml Penicillin and 50 ⁇ g/ml streptomycin and cultured together in a 6-well tissue culture plate (Nunc) in 5% CO2 at 37°C.
  • expanded neurospheres were cultured as a monolayer from disrupted neurospheres that are in turn, derived from primary olfactory mucosal cells (olfactory epithelium + lamina basement), as described in Murrell et al., 2005, supra.
  • cells were passaged using 0.25% trypsin in 0.02% EDTA (GIBCO-Invitrogen) and seeded onto poly-L-lysine (0.85 ⁇ g/cm2; Sigma) coated 6-well tissue culture plates (Nunc) in DMEM/F12 supplemented with Insulin, Transferrin and Sodium Selenite (ITS; GIBCO- Invitrogen), 50 ng/ml Epidermal Growth Factor (EGF; Chemicon) and 25 ng/ml Fibroblast Growth Factor 2 (FGF2; Chemicon) to generate neurospheres. After 7-8 days, the neurospheres were collected.
  • ITS Insulin, Transferrin and Sodium Selenite
  • pOS cell enrichment medium DMEM containing 4.5 g glucose/L; 20% (v/v) heat-inactivated (56C; 30 mins) foetal bovine serum; 2 mM Glutamax-1 or 2 mM L-glutamine; 1 mM Na pyruvate; 0.1 mM non-essential amino acids; 30 ⁇ M adenosine; 30 ⁇ M guanosine; 30 ⁇ M cytidine; 30 ⁇ M uridine; 10 ⁇ M thymidine; 50 U penicillin/mL; 50 ⁇ g streptomycin/mL; 50 ⁇ g gentamicin/mL; 0.1 mM beta-mercaptoethanol.
  • Mouse pOS cells were cultured on mitotically-inactivated S1/S14 mSCF220 stromal feeders, in pOS cell enrichment medium supplemented wtih 1 or more of: 1,000 units ESGRO murine LIF/mL; 40 ng recombinant murine Stem Cell Factor/mL; 20 ng recombinant human FGF-2/mL; 25 ng recombinant human FGF9/mL.
  • the cells were then seeded into a tissue culture-grade flask / dish / multi-well plate, pre-coated with 0.1% (w/v) gelatin (type A from porcine skin) and containing a confluent monolayer of mitotically-inactivated S1/S14 stromal cells, expressing a truncated, surface membrane-bound form of murine Stem Cell Factor.
  • pOS cells are cultivated on feeders in pOS cell enrichment medium (37C; 5% CO2 in humidified air). Medium is replaced daily. Cells are passaged every 2-3 days at 60-70% confluency and are seeded into new flasks, pre-coated with gelatin and containing new feeders at a dilution of 1:5 - 1:10.
  • pOS cells may be cultivated on gelatin in the absence of feeders for a short period without detectable changes to their phenotype.
  • the attainment of a stable, homogeneous population of pOS cells occurs as early as three weeks following initiation of culture of primary cells or expanded neurospheres in pOS cell enrichment medium.
  • Mouse pOS cells that are derived from primary cells exhibited a stable and homogeneous phenotype that is very similar to that shown by murine pOS cells that are derived from expanded neurospheres.
  • B6 Rosa26-EGFP XY pOS An example of an isolated mouse cell designated B6 Rosa26-EGFP XY pOS was deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121601
  • Murine pOS cells were produced as hereinbefore described and analysed for expression of CD antigens, intracellular OCT-3/4 and SCA-I by flow cytometry.
  • CD (cluster of differentiation) antigens are proteins expressed on the cell surface that are antigenic.
  • Mouse pOS cells were plated into a 96-well plate format. Each well was coated with one antibody, reactive against one species-specific CD or other antigen. All antigens tested are shown in Table 6.
  • Table 7 provides a ranking of expression levels according to mean fluorescence intensity.
  • Highest mean expression levels (>18,000 MFI units) were identified for CD13; CD16/32; CD23; CD34; CD28; CD38; CD40; CD45; CD61; CD69; CD95; CDl 17; CD122; CD124; CD201; and CD309.
  • GFP-dim or GFP-negative pOS cells from C57BL/6J ROSA26- EGFP/ROSA26-EGFP mice were collected by fluorescence-activated cell sorting (FACS), and injected into wild type C57BL/6J pre-implantation-stage mouse blastocysts.
  • Immunophenotypic analysis of pOS cells was performed on GFP negative cells grown at 37C and 5% CO2 in humidified air in pOS enrichment (POSE) medium, treated with trypsin and then fixed in 4% paraformaldehyde for 10 min at room temperature (RT).
  • PSE pOS enrichment
  • Triton-X 100 together with the following antibodies: anti-human/mouse SOX2 Allophycocyanin (APC)-conjugated (IC2018A, R&D), anti-human NESTIN phycoerythrin-conjugated (IC1259P, R&D), rabbit anti-OCT4 (AB3209, Chemicon), rabbit anti-human-NANOG (AB9220, Millipore), rabbit anti-KLF4 (AB4138, Millipore) and anti-MYC (9402, Cell Signalling Technology).
  • APC anti-human/mouse SOX2 Allophycocyanin
  • IC2018A, R&D anti-human NESTIN phycoerythrin-conjugated
  • IC1259P anti-OCT4
  • rabbit anti-OCT4 AB3209, Chemicon
  • rabbit anti-human-NANOG AB9220, Millipore
  • rabbit anti-KLF4 AB4138, Millipore
  • anti-MYC
  • OCT-3/4 and SOX2, KLF4, c-MYC, NANOG and a neuronal stem cell marker (NESTIN) were analysed in murine ES cells and pOS cells ( Figure 9).
  • OCT-3/4 and SOX2 expression were also compared between MEF, mouse ES cells and mouse pOS cells, as summarized in Figure 10.
  • OCT-3/4-positive staining was observed in all cell types but the level of expression was greater in the ES cells (48.6 vs 25.1). In both cases the staining was considered moderate to high.
  • SOX2 staining was moderate to high in ES cells and was low to moderate in 47% of pOS cells.
  • NESTIN was positive in only 5% of the ESC with very low levels of expression and in 23% of the pOS cells with low to moderate levels of expression.
  • KLF4, c-MYC and NANOG expression was clearly detected.
  • the MFI of each of these proteins was similar in mouse ES cells and mouse pOS cells. This suggests that these factors may be active in the maintenance of pluripotency in pOS cells.
  • mice pOS cells expressed low but detectable levels of SOX2 and OCT-3/4, whereas NANOG, KLF4, MVH, KIT and NESTIN proteins were expressed more abundantly.
  • Murine pOS cells were also analysed for CDl 17 and AP-2 ⁇ expression
  • Mouse anti- mouse AP-2 ⁇ Ab was used at a 1 :200 dilution with a rabbit anti-mouse Alexa 594 secondary Ab at a 1:200 dilution.
  • Rat anti-mouse CDl 17 Ab was used at a 1:50 dilution with a donkey anti-rat Alexa 594 secondary Ab at a 1 :200 dilution.
  • AP-2 ⁇ is a transcription factor and downstream target of Prdml. AP-2 ⁇ mediates the suppression of somatic differentiation and the reacquisition of pluripotency (Weber, S. et al. Biol Reprod 2009 [PMID: 19776388]).
  • CDl 17 is a regulator of gametogenesis, mast cell development, haematopoiesis and melanogenesis. Loss of function mutations in CDl 17 results in dose-dependent anaemia, hypopigmentation, infertility and survival.
  • Gain of function mutations in CDl 17 are associated with a range of neoplasms, including acute myelogenous leukaemia, gastrointestinal stromal tumours and mastocytomas (Roskoski, 2005, Biochem Biophys Res Commun; 337: 1-13). Both AP-2 ⁇ and CDl 17 were expressed abundantly by pOS cells, suggesting a role for these factors in the maintenance of pOS cell pluripotency.
  • Testis morphology Fixed testis sections (3 um thickness) of left (injected) and right (uninjected) testes, harvested from NOD-SCID male mouse at 3 months after injection of 1-1.5 x 10e6 pOS cells beneath the capsule of the left testis.
  • the tumour mass comprised fibrocytes of mesenchymal origin.
  • the morphology of the injected pOS cells was the same as that of the cells making up the bulk of the fibrosarcoma.
  • Cell source Cells were obtained from expanded neurospheres cultured as a monolayer from disrupted neurospheres that are in turn, derived from primary olfactory mucosal cells (olfactory epithelium + lamina basement), as hereinbefore described. It is anticipated that cells may be obtained from expanded primary adult human olfactory mucosal cells (olfactory epithelium + lamina propria).
  • Human cells were cultured on mitotically-inactivated S1/S14 hSCF220 stromal feeders, in pOS cell enrichment medium supplemented with one or more of: 1,000 units glycosylated human LIF/mL; 40 ng recombinant human Stem Cell Factor/mL; 20 ng recombinant human FGF-2/mL; 25 ng recombinant human FGF9/mL; 5 ng recombinant human TGF- ⁇ 2/mL; 10 ng recombinant human BMP-4/mL.
  • pOS cell enrichment medium supplemented with one or more of: 1,000 units glycosylated human LIF/mL; 40 ng recombinant human Stem Cell Factor/mL; 20 ng recombinant human FGF-2/mL; 25 ng recombinant human FGF9/mL; 5 ng recombinant human TGF- ⁇ 2/mL; 10 ng recombinant human BMP-4
  • Table 8 shows all of the growth factor combinations tested that have yielded human pOS cells from expanded neurospheres. The attainment of a stable, homogeneous population of human pOS cells occurs as early as three weeks following initiation of culture expanded neurospheres in pOS cell enrichment medium.
  • FIG. 7B An example of a human pOS cell is shown in Figure 7B.
  • pOS cells represent a new member of the pluripotent stem cell family with significant potential clinical application. Unlike other pluripotent stem cells, pOS cells do not form teratomas or tumours after transplantation and they could provide a source of autologous or non-autologous human stem cells for therapy. Human olfactory mucosa is safely accessible via biopsy through the external naris and multipotent olfactory neurosphere-derived cells. These may provide a source of human pOS cells.
  • Human pOS cell cultures were initiated from expanded human neurospheres in flasks pre-coated with 0.1% (w/v) gelatin and seeded with a confluent monolayer of mitotically-inactivated Sl/S14-hSCF220 feeders. The cells were cultured in POSE medium, either without added growth factors, or supplemented with the six growth factors (LIF, SCF, FGF- 2, FGF9, TGF ⁇ 2, as indicated in Table 8.
  • XS refers to expanded neurospheres
  • no GF's refers to an absence of growth factors (Cate did these cultures include feeders?)
  • 6 GF's refers to culture in the presence of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF- ⁇ 2.
  • Table 9 shows a ranked, fold change in expression of genes compared between pOS cells cultured with or without a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF- ⁇ 2 and expanded neurospheres from which the pOS cells were derived.
  • Table 10 shows a ranked, fold increase or induction in expression of genes in pOS cells cultured with a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF- ⁇ 2 compared to expanded neurospheres from which the pOS cells were derived.
  • Table 11 shows fold decrease in expression of genes compared between pOS cells cultured with or without a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF- ⁇ 2 and expanded neurospheres from which the pOS cells were derived.
  • Table 12 shows a ranked, fold difference in expression of genes compared between pOS cells cultured with and without a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF- ⁇ 2.
  • the expressed PluriNet genes in human neurospheres from which a human isolated mammalian cell may be derived are shown in Table 5. These genes were expressed in neurospheres before transfer to the POSE medium, and not because of the POSE medium.
  • Cell source Cells were obtained from expanded primary adult rat olfactory mucosal cells
  • DMEM containing 4.5 g glucose/L; 20% (v/v) heat-inactivated (56C; 30 mins) foetal bovine serum; 2 mM Glutamax-1 or 2 mM L-glutamine; 1 mM Na pyruvate; 0.1 mM non-essential amino acids; 30 uM adenosine; 30 uM guanosine; 30 uM cytidine; 30 uM uridine; 10 uM thymidine; 50 U penicillin/mL; 50 ug streptomycin/mL; 50 ⁇ g gentamicin/mL; 0.1 mM beta-mercaptoethanol.
  • Rat pOS cells are cultured on mitotically-inactivated S1/S14 mSCF220 stromal feeders, in pOS cell enrichment medium supplemented with 1 or more of:
  • pOS cells are cultivated on feeders in pOS cell enrichment medium (37C; 5%
  • pOS cells may be cultivated on gelatin in the absence of feeders for a short period without detectable changes to their phenotype.
  • Plurinet_ortholog> list median normalised pOS cells Rosa Mus
  • MRE11 B MRE11; ATLD;
  • BM28 CCNL1 ; CDCL1; cdc19; MITOTIN; CDCL1; D3S3194; MITOTIN; KIAA0030; KIAA0030; D3S3194; BM28; MGC 10606 cdc19 NM_004526 CDC2; POLD CDC2; POLD NM_002691
  • PrP33-35C PrPc PrP
  • PrP PrP
  • DBK DBK; PKN; PAK1; PRK1; PRKCL1; PRKCL1; PAK1 ; PKN; DBK;
  • DIL2 p100; DIL-2; HCTP4; FLS353; C20orf1; FLS353; DIL-2;

Abstract

An adult mammalian stem cell is provided which is pluripotent and non-teratogenic in immune deficient animals. The mammalian stem cell is obtainable by culturing olfactory epithelium in the presence of one or more of FGF2, FGF9, SCF, LIF, TGF- β2 and BMP-4. The mammalian stem cell expresses low levels of Sox2 and Oct4 mRNA and higher levels of SP1 and ANP32A mRNA. The mammalian stem cell expresses one or more proteins such as OCT-3./4, SOX2, NANOG, KLF4, MVH, KIT, NESTIN and also selected CD antigens. The mammalian stem cell may be useful in compositions and methods for treating diseases or conditions responsive to cell-based therapies, including but not limited spinal repair, heart muscle regeneration, skin repair, bone-marrow transplantation and repair of neural degeneration. The mammalian stem cell and non-human mammals generated therefrom may be useful in drug screening, disease modelling and identifying cell differentiation pathways.

Description

TITLE
A GERMLINE COMPETENT CELL DERIVED FROM ADULT TISSUE
FIELD
THIS INVENTION relates to pluripotent mammalian cells and to methods of isolating, culturing and using same.
BACKGROUND
Pluripotent cells are cells that have the potential to differentiate into all cell types found in an adult organism, except for certain placental tissue and umbilicus. These cells naturally occur in the inner cell mass of an embryo and they differentiate to form three embryonic germ layers: ectoderm, endoderm and mesoderm. It is from these three germ layers that all adult tissues in a human are formed. There is considerable interest in using pluripotent cells in drug development and discovery, gene therapy and cell and tissue therapy. There has been clinical application of these cells in in vitro fertilisation and tissue and cellular regeneration and replacement therapies.
Pluripotent cells known to date may be classified into 3 groups. The first of these includes cells derived predominantly from embryonic tissue such as: (i) embryonic stem cells (ESCs), which are derived by long-term culture of cells from the inner cell mass of a blastocyst (Thomson et al. 1998 Science 282:1145-1147); and (ii) embryonic germ cells (EG cells), which are derived from migratory primordial germ cells found in the region of the hind gut in transit to the genitalgonadal ridge in E8.5 - E9.5 mouse foetuses (Shamblott et al. 1998 PNAS USA 10:13726-31). EG cells of a late embryo have many of the properties of ESCs. The primordial germ cells in an embryo develop into stem cells that in an adult generate the gametes. These cells are generally derived from embryos (created naturally or via cloning), fetal tissue or via the mixing of nucleus and cytoplasm of multiple species. Reprogramming of somatic cells to cells exhibiting pluripotent properties has been achieved by nuclear transplantation of a somatic nucleus into an enucleated egg. There are ethical issues that arise from the derivation of these cells. A second group includes those cells obtained by introducing defined transcription factors into somatic cells. Cells formed by expression of a combination of transcription factors (e.g SOX2, OCT-3/4, NANOG and KLF4) expressed from a retrovirus or other compounds are referred to as "induced pluripotent stem cells" or "iPS cells" (Takahashi & Yamanaka, 2006, Cell 126:663-676).
Until recently, adult stem cells have been thought not to be pluripotent although recent studies have cast some doubt on this thinking. In this context some adult stem cells are thought to represent a third class of pluripotent cells.
The in vivo developmental potency of a given cell may be determined by assessing for germline competency or, for teratoma formation in an immune deficient animal.
A "germline competent" cell is capable of giving rise to functional gametes. One form of assessing germline competence includes injecting a candidate cell into a blastocyst and determining whether Fl derived from an intercross involving a founder derived from the blastocyst contains the genetic complement of the candidate cell. Germline competency is a defining feature of all pluripotent cells.
The capacity to form a teratoma - a tumour containing tissue that is characteristic of endodermal, ectodermal and mesodermal lineages- is also understood to indicate that the candidate cell has pluripotency in vivo. All pluripotent cells known to date - ESCs, EG cells and iPS cells - have this defining property. It is generally understood that teratoma formation occurs as a consequence of a
"reprogramming" of the cell during culture to differentiate when placed in an environment in the absence of LIF. That is, the differentiation is a function of the cell itself, rather than stimuli from the tissue environment in which it is placed. As an example, inner cell mass cells generally do not form teratomas whereas ESCs do.
Teratoma formation is generally understood to be a significant limitation to the use of all pluripotent cells identified to date in clinical applications. More particularly, it is generally understood that there is a significant risk that pluripotent cells identified to date will cause teratomas or other forms of neoplasia or unregulated cell or tissue growth if used in clinical applications.
SUMMARY The present invention is broadly directed to a mammalian pluripotent stem cell that is obtainable from adult cells and/or tissues. A preferred advantage of the mammalian pluripotent stem cell is that it does not form teratomas. In one aspect, there is provided an isolated mammalian cell having the developmental potency of an embryonic stem cell (ESC), characterised in that the isolated mammalian cell does not form a teratoma when provided in an immune deficient animal. Suitably, the isolated mammalian cell is a germline competent, pluripotent stem cell.
The isolated mammalian cell may be further characterized by a presence, absence, relatively high or relatively low level of expression of one or more genes or proteins set forth in Tables 1-12. In particular embodiments, the invention provides:
(i) an isolated human cell designated Human XY pOS-17 deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121602;
(ii) an isolated mouse cell designated B6 Rosa26-EGFP XY Pos deposited at the European Collection of Cell Cultures (ECACC) on
December 16 2009 with accession number 09121601; and/or
(i) an isolated rat cell designated SD Rat XY pOS deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121603. In another aspect, the invention provides a method of producing a mammalian cell, said method including the step of culturing a one or more cells or tissues obtained from a mammal in a medium including one or more of FGF9, FGF2, SCF and LIF, to thereby produce the isolated mammalian cell.
In one particular embodiment, the method includes culturing neurospheres or a neurosphere-like cellular mass in a medium comprising one or more of FGF2, FGF9, SCF and/or leukaemia inhibitory factor (LIF).
In a particular embodiment of this aspect relating to human cells, the medium includes one or more of FGF2, FGF9, SCF, LIF, TGF-β2 and/or BMP-4.
In further embodiments, the method includes: (a) forming a neurosphere or a neurosphere-like cellular mass; and (b) isolating the mammalian cell from the neurosphere or neurosphere-like cellular mass, thereby providing the isolating mammalian cell. Preferably, the one or more cells or tissues, inclusive of the neurosphere or a neurosphere-like cellular mass, are obtainable from adult olfactory epithelium.
This aspect of the invention also provides an isolated mammalian cell obtainable by the method of this aspect. In yet another aspect, there is provided a method of producing a differentiated mammalian cell, said method including the step of culturing the isolated mammalian cell of any of the aforementioned aspects under conditions which facilitate the production of the differentiated cell.
This aspect of the invention also provides a differentiated cell obtainable by the method of this aspect.
In one particular embodiment of the aforementioned aspects, there is provided an isolated mammalian cell, or differentiated cell, transformed or transfected with an isolated nucleic acid.
Preferably, the isolated nucleic acid is, or is provided in, a genetic construct. In one particular embodiment, the isolated nucleic acid encodes a therapeutic agent.
In a further aspect there is provided a composition comprising an isolated mammalian cell according to the aforementioned aspects and/or a cell differentiated therefrom; and a suitable carrier, diluent or excipient. In another further aspect there is provided a method of treatment of a disease or condition in a mammal, said method including the step of administering an isolated mammalian cell according to the aforementioned aspects and/or a cell differentiated therefrom to said mammal to thereby treat said disease or condition.
In yet another further aspect there is provided an isolated mammalian cell according to the aforementioned aspects and/or a cell differentiated therefrom for use in treating a disease or condition mammal.
In a yet still further aspect there is provided a method of producing a non- human mammal, said method including the steps of:
(i) delivering one or more isolated mammalian cells of the aforementioned aspects to a blastocyst of a non-human mammal; and (ii) producing one or more progeny from said blastocyst. Suitably, the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
Preferably, the method further includes the step of implanting or otherwise transferring the blastocyst produced at step (i) to a female non-human mammal.
In one embodiment, one or more isolated mammalian cells delivered at step (i) are genetically modified, wherein the progeny produced at step (ii) are genetically modified.
This aspect of the invention also includes a genetically-modified non-human mammal obtainable by the method of this aspect.
In a still yet another further aspect, the invention provides a method of identifying, designing, screening or otherwise producing a compound having a desired activity, said method including the step of: (i) contacting a candidate compound with an isolated mammalian cell of any of the aforementioned aspects, or a cell differentiated therefrom; or (ii) administering a candidate molecule to a non- human mammal produced according to the method of the aforementioned aspect, to thereby produce a compound having said activity.
Non-limiting examples of activities include cell growth and/or differentiation, anti-tumour activity, pro- or anti-apoptotic activity, neuropharmacological activity; regulation of metabolism; hormonal activity; gene regulatory activity; cell cycle regulation and immunoregulatory activity,
In particular embodiments of each of the aforementioned aspects, the mammal is a preferably human, rat or mouse.
Preferably, in aspects relating to non-human mammal, the non-human mammal is a rat or a mouse.
As used herein, except where the context requires otherwise, the term "comprise" and variations of the term, such as "comprising", "comprises" and "comprised", are not intended to exclude further additives, components, integers or steps.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1: Pluripotent adult stem cells were derived from adult olfactory mucosa. Cells from adult, Rosa-EGFP mouse olfactory mucosa were grown as neurospheres, dissociated and cultured for 48 hours as an adherent monolayer of expanded neurospheres in the presence of EGF and FGF2 for 2 days. The cells were then trypsinised and grown in POSE medium on mouse stromal feeder layers for 2 weeks (A) or 3 weeks (B) after which they were sorted on the basis of EGFP fluorescence, Y-axis, and forward scatter (X-axis (A, B). Prior to sorting, EGFP-negative cells were of similar undifferentiated phenotype (C). After sorting they were small and round (D). Scale bar = 100 μm. E: qPCR genotyping identified the EGFP amplicon in tail-tip DNA from 9 out of 13 live born offspring created from blastocyst injection of EGFP-dim cells (First experiment in G). Controls were DNA from non-transgenic mouse (WT negative control) and Rosa-EGFP mouse (EGFP-positive control). F: qPCR Control for FoxL2 amplicon from the same DNA samples. G: Summary Table of 67 separate blastocyst injections using EGFP-dim and EGFP-negative cells and different numbers of cells injected. Figure 2: EGFP was detected in many tissues in chimeric mice and throughout the tissues of progeny of germ-line chimeras. Immunochemistry detects EGFP in chimeric mouse generated from blastocyst injection of a single pOS cell (A-C). Small green dots are autofluorescence in blood cells which are also seen in controls (D-I). D-F: Negative control, adjacent section without primary antibody. G-I: Negative control, wild-type non-EGFP mouse with primary antibody. Images A-I are confocal, taken on the same settings, from similar regions of the embryo: A, D, G, head region showing brain (b); B, E, H, mid-region showing lung (Iu), skin (sk), dorsal root ganglia (drg); C, F, I, lower region showing liver (Ii), spinal cord (sc), stomach (st). All images show EGFP, autofluorescence, and DAPI-labelled nuclei. Bar (in I) = 200 μm. J-O: Fluorescence immunochemistry detects EGFP in transgenic offspring of chimeric founder (Pup 11 in Fig. IE, F) (J). Autofluorescence only is detected in Negative Controls: no primary antibody on adjacent section (L) and non EGFP mouse with primary antibody (N). K, M, O are the same sections as J, L, N, imaged for DAPI-labelled nuclei. Bars = lmm (J, K) and 2 mm (L-O). Figure 3: pOS cells express genes associated with pluripotency. A recent study identified 300 genes (the "PluriNet") associated with pluripotency in embryonic stem cells, induced pluripotent stem cells and embryonic carcinoma cells15. 273 probes on the mouse Illumina array map to 265 PluriNet members. A: Graph of expression of 166 PluriNet genes in different populations of olfactory cells: Reference (dissociated neurosphere cells prior to pOS cell culture and selection), Bright (EGFP-bright cells negatively selected from pOS cell cultures), Dim (EGFP-dim, pOS cells selected for initial blastocyst injections), Negative (EGFP-negative cells selected for blastocyst injections). Y-axis shows log normalised intensity for each gene: Grey shows genes not detected or reduced in Negative pOS cells. Lighter shading shows genes expressed in Negative pOS cells but neither reduced or enriched. Darker shading shows genes enriched in Negative pOS cells.
B: Relative expression in pOS cells of the chromatin modification subnetwork of PluriNet. Genes are shown that are significantly repressed or enriched in Negative pOS cells compared to Reference cells (p<0.01). Low or no expression of two of the key pluripotency genes Nanog and Oct4 are also associated with low levels of expression of protein-partners and adjacent network members. The chromatin targets Myc, Klf4/5, HDACl are induced in pOS cells, as are the cell cycle subnetworks associated with PluriNet. C: Immunofluorescence for key pluripotency proteins. Left column: antibodies against: Sox2 (top line), Oct4 (2nd line), Nanog (3rd line) and Klf4 (bottom line). Middle column: the same cells imaged for D APIDAP-label led nuclei. Right column: merged images of other columns. Sox2, Oct4, and Nanog mRNAs were below detection thresholds on the microarray but their proteins were detected in about 10% of cells.
Figure 4: Fl, F2 offspring of FO chimaeras.
Detection of pOS cell-derived EGFP expression in first and second generation offspring of chimaeric founder mice. On each slide the first column shows sections from the wild-type control reacted for anti-EGFP immunochemistry, the second column shows sections from the animals listed but without primary antibody, and the third column shows sections from the animals listed with primary antibody. Nuclei stained with DAPI. Endogenous EGFP expression visualised using a rabbit anti- EGFP primary antibody and an Alexa-488-conjugated goat anti-rabbit antibody. Each foetus is imaged using darkfield (DF), DAPI-labelled nuclei and EGFP filters, using an Olympus BX-51 fluorescent microscope and DP Manager software. Key to nomenclature: WT6 — Wild-type, non-transgenic control FoI 1, Fo2, FoIO, FoI 3 - Chimaeric founders 11, 10, 13 and 2, respectively. FoI 1/Fl 1 — 1st generation pup #1 bred from chimaeric founder #11.
FoI 1/F12 - 1st generation pup #2 bred from chimaeric founder #11.
Fol l/F13 - lst generation pup #3 bred from chimaeric founder #11.
Fol l/F14 - lst generation pup #4 bred from chimaeric founder #11. Fol l/F16 - lst generation pup #6 bred from chimaeric founder #11.
F02/F11/F21 - 2nd generation pup #1 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
F02/F11/F22 - 2nd generation pup #2 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2. F02/F11/F23 - 2nd generation pup #3 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
F02/F11/F24 - 2nd generation pup #4 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
F02/F11/F25 - 2nd generation pup #5 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
F02/F11/F26 - 2nd generation pup #6 bred from 1st generation Tg mouse #1, descended from chimaeric founder 2.
Fo 10/Fl 1 - 1st generation pup #1 bred from chimaeric founder #10.
Fo 10/Fl 3 - 1st generation pup #3 bred from chimaeric founder #10. Fo 13/Fl 1 - 1st generation pup #1 bred from chimaeric founder #13.
Fo 13/Fl 3 - 1st generation pup #3 bred from chimaeric founder #13.
Figure 5: EGFP immunochemistry in chimeric embryo SC14 after injection of a single pOS cell into a blastocyst. A, C, E, G: EGFP immunoreactivity in different tissues. B, D, F, H: Negative control - nearby sections without primary antibody showing autofluorescence, predominantly in blood cells. A, B: Sections through limb bud (Ib). C, D: Sections through head showing developing brain (b). E, F: Sections through liver (i) and lung (Iu). G, H: Sections through spinal cord (sc) and dorsal root ganglion (drg). All images are composites of two images at different excitation and emission wavelengths: green (for EGFP), and red (for autofluorescence). All images show autofluorescent blood cells. Photomicrographs were taken on a Zeiss
Axio Imager Zl epi-fluorescence microscope at the same exposures and assembled in Adobe photoshop and Adobe Illustrator without adjustment. Scale bar = 200 μm. Figure 6: qPCR for pluripotency gene expression in pOS cells. Positive controls (lighter shaded bars) indicate gene expression in primordial germ cells (PGCs) from El 1.5 embryos. Gene expression in pOS cells (darker shaded bars) and PGCs is expressed relative to the internal control, 18S ribosomal RNA sub-unit. Figure 7: A: Mouse pOS cells; B: human pOS cells; and C: rat pOS cells.
Figure 8: Injection of 1 pOS cell into one blastocyst is sufficient to generate male and female chimaeric founder (Fo) mice and Fl offspring. PCR detection of an EGFP amplicon was performed using DNA obtained from Fl progeny of an Fo2 female. Figure 9: Expression of OCT-3/4, SOX2, NANOG and NESTIN in murine ES cells and pOS cells. Representative flow cytometry analysis of cell number (count) vs fluorescence intensity. The unshaded histogram shows the binding profile of anti- Oct4, anti-Sox2 and anti-Nestin. The shaded histogram shows the binding of the isotype-matched control antibody. The % of positive cells and the normalized mean fluorescence intensity (nMFI= MFImarker/MFIisotype) is shown for each marker.
Figure 10: Bar graph showing comparison of Sox2 and Oct4 expression by murine pOS cells, murine ES cells and murine embryonic fibroblast (MEF) cells.
DETAILED DESCRIPTION The inventors have produced an isolated mammalian cell obtainable or derivable from adult mammalian tissue. The isolated mammalian cell has germline competency, and therefore is by definition, a pluripotent stem cell. As exemplified herein the genetic complement of the isolated mammalian cell is inherited in Fl progeny formed from a founder mammal produced from a blastocyst into which the cell has been injected or otherwise delivered.
Further, as exemplified herein, the genetic complement of the cell can be identified in tissues derived from ectodermal, endodermal and mesodermal lineages of mammals produced from a blastocyst into which the cell is delivered.
Surprisingly, as exemplified herein the inventors have observed that the isolated mammalian cell is unable to form a teratoma when provided in an immune deficient animal. Further none of the founders, Fl or progeny derived therefrom to date have been found to have neoplastic or other uncontrolled cell or tissue growth. The finding suggests that the culture methodology and/or conditions that the inventors designed to produce the isolated mammalian cell of the invention are unlike those for derivation of ESCs and EG cells in that they do not appear to reprogram the cell of the invention for teratoma formation. It will be understood that having produced a isolated mammalian cell capable of self renewal, that cell can then be produced by a variety of processes including those described further herein.
For the purposes of this invention, by "isolated" is meant material (e.g. cells) that has been removed from its natural state or otherwise been subjected to human manipulation. Isolated material may be partly, substantially or essentially free from components that normally accompany it in its natural state, or may be manipulated so as to be in an artificial state together with components that normally accompany it in its natural state. The term "isolated" also includes "enriched" or "purified", which in the context of cells, means that the frequency or proportion of cells after enrichment or purification is greater than before enrichment or purification.
Thus in one aspect there is provided an isolated mammalian cell having the developmental potency of an embryonic stem cell (ESC), the cell being characterised in that the cell does not form a teratoma when provided in an immune deficient animal.
In certain embodiments, the isolated mammalian cell is of human, mouse or rat origin. An isolated mammalian cell having the developmental potency of an ESC is typically one that is capable of differentiating to form tissues derived from mesodermal, endodermal and ectodermal lineages. Typically the cell is also capable of self renewing proliferation.
An isolated mammalian cell having the developmental potency of an ESC is not a totipotent cell. An ESC does not form extra embryonic tissues. In contrast to a pluripotent cell, a "totipotent cell" is defined as a cell that may differentiate into an entire organism. A totipotent cell has the capability to develop into a complete embryo including extra-embryonic cell types. In this context, a "pluripotent cell" is generally understood as meaning a cell that may differentiate into all cell types that constitute an organism. A pluripotent cell cannot develop into any extra-embryonic cell types. Other cells that have the developmental potency of an ESC include embryonic germ cells (EG cells) and induced pluripotent stem cells (iPS cells). However, these cells form a teratoma when provided in an immune deficient animal.
It will therefore be appreciated that in one embodiment, the invention provides a pluripotent stem cell, that does not form a teratoma when provided in an immune deficient animal. Suitably, the pluripotent stem cell is obtainable, derivable or otherwise produced from adult tissue.
A teratoma is generally understood as meaning a malignant tumour that contains tissues derived from all three embryonic layers (mesoderm, endoderm and ectoderm) including bone, muscle, cartilage, nerve, tooth buds and various glands.
Prior to the invention, teratoma formation in an immune deficient, or immune compromised animal such as a SCID mouse had been regarded as a defining characteristic of pluripotency. Assays for teratoma formation generally involve the injection of candidate pluripotent cells into such an animal and examination of the animal after a period in which a teratoma or related tumour would be expected to have formed without any other cell growth stimuli. The isolated mammalian cell according to the invention is characterised in that it does not form a teratoma under these assay conditions.
In certain embodiments the isolated mammalian cell retains an undifferentiated phenotype when provided in an immune deficient animal. For example, the cell may not differentiate in the immune deficient animal. In these embodiments, after injection into an immune deficient animal the cell may retain capacity for self renewal. For example, the isolated mammalian cell may retain the developmental potency of an ES, EG or iPS cell. In another embodiment, the cell may retain the phenotype of a multipotent stem cell.
A "multipotent cell" is generally understood as meaning a cell that can develop into several cell types. A multipotent cell does not have the capability to develop into a complete embryo nor does it have the capacity to develop into all cell types that constitute an organism.
In other embodiments the cell may differentiate in the immune deficient animal to form tissue and cellular elements of the tissue in which it is placed. In other embodiments the cell may migrate to another site in the immune deficient animal or undergo cell death.
It will also be appreciated from the foregoing that the inventors have produced a germline competent cell. A germline competent cell is a cell that when injected into a blastocyst can give rise to germ cells. These germ cells can then give rise to progeny.
It will therefore be appreciated that in one embodiment, the invention provides a germline competent cell, that does not form a teratoma when provided in an immune deficient animal. Suitably, the germline competent cell is obtainable, derivable or otherwise produced from adult tissue.
The isolated mammalian cell hereinbefore described is obtainable, derivable or otherwise produced from adult cells or tissues. Non-limiting examples include bone marrow, central nervous system tissue, neural tissue, skin, gut, pancreas, muscle, brain, heart, adipose, olfactory mucosa or other mucosa or epithelia. Typically the tissue is olfactory mucosa.
It will also be appreciated that isolated mammalian cells of the invention may be characterized by levels of gene expression. Levels of gene expression may be relative levels of gene expression compared to a Reference cell, or may be detected as the presence or absence of expression of a particular gene. Typically, although not exclusively, this may be through detection and/or measurement of RNA expression. This may be by transcriptome analysis or by mRNA expression profile analysis, for example. Suitable techniques for analysis of gene expression are provided in the Examples herein, inclusive of microarray analysis, RT-PCR, northern blotting and other techniques known in the art. The inventors have determined the protein-coding transcriptome of the isolated mammalian cell of the invention. The inventors have compared the transcriptome with PluriNet genes - a regulatory network of genes that is shared by pluripotent ES cells, embryonal carcinomas and iPS cells - to identify genes in the isolated mammalian cell of the invention that are also expressed in these pluripotent cells. Surprisingly the inventors have found that certain genes that have been observed as being associated with pluripotency in these pluripotent cells are not actively transcribed in the isolated mammalian cells of the invention. These are Sox 2, Oct3/4, all of which appear to have little or no transcription, and Nanog which appears to have very little transcription.
While not wishing to be bound by hypothesis, the inventors recognise that the unique differences in mRNA expression profile of the isolated mammalian cell of the invention as compared with known pluripotent cells may mean that the isolated mammalian cell of the invention is incapable of forming teratoma because it does not have expression of certain genes that are observed in known pluripotent cells. By extension it is recognised that the invention identifies the genes that are transcribed in known pluripotent cells but not in the isolated mammalian cell of the invention as being tumourigenic genes that are not necessary for germline competency.
In one embodiment, the isolated mammalian cell according to the invention does not contain, or contains relatively low amounts of Sox 2 or Oct3/4 mRNA.
Typically the isolated mammalian cell does not contain, or contains relatively low amounts of one or more of SET, ZFP42, HMGBl or ARID38 mRNA. Typically the isolated mammalian cell does not contain, or contains relatively low amounts of one or more of the mRNAs shown in Table 3 herein.
Typically the cell does not contain, or contains relatively low amounts of DNMT3b, HDAC2 and Nanog mRNA.
In embodiments where the isolated mammalian cell, or a population of said cells, does not contain, or contains relatively low amounts of one or more mRNAs, it will be understood that the isolated mammalian cell does not contain a detectable level of the mRNA, or contains an amount that is significantly lower than in a
Reference cell or cell population. Accordingly, the isolated mammalian cell or population of said cells preferably contains a relative amount or abundance of said mRNA that is less than 50%, less than 40%, less than 30%, less than 20%, less than
15%, less than 10%, less than 5%, less than 2% or less than 1% of that of a
Reference cell or cell population.
A preferred Reference cell is a neurosphere-derived cell.
A preferred method of mRNA quantification is quantitative PCR. In another embodiment, the isolated mammalian cell may contain SPl and/or
ANP32A mRNA.
Typically the isolated mammalian cell may contain one or more mRNAs shown in Table 2 herein. Typically the cell may contain one or more of Myc, HMGAl, SMARCADl, SMARCCl, PTMA, MCM6, PCNA, HDACl, KLF5, KLF4, BTBD14B, HoxA5, FoxAl, Meisl and/or ENl mRNA. These mRNAs are enriched in the isolated mammalian cell of the invention as compared with Reference cells (described further herein) from which they are derived. Although not wishing to be bound by theory, it is possible that culture conditions exemplified herein effectively direct the emergence and/or phenotype of the isolated mammalian cell of the invention.
In one embodiment, the isolated mammalian cell may express one or more genes at a level at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold or at least 20-fold greater than that of a Reference cell or cell population.
For example, the cell may contain one or more mRNAs shown in Table 1 herein, wherein the Reference cell is, or derived from, expanded neurospheres.
In other particular embodiments, the isolated mammalian cell has a profile of mRNA expression substantially as shown in Table 4 or Table 5 herein. In yet another particular embodiment, an isolated human cell of the invention is characterized by a presence, absence, relatively high or relatively low level of expression of one or more genes (e.g mRNAs) set forth in any one of Tables 9-12. As will described in more detail in the Examples and is evident from Tables 9-12, microarray analysis of genes expressed in human cells of the invention has revealed that certain genes are expressed at higher or lower levels human cells compared to neurosphere-derived cells from which the cells were cultured. It is also evident that exposure to growth factors such as FGF-2, FGF9, leukaemia inhibitory factor (LIF), SCF, BMP-4 and/or TGFβ2 modulates gene expression in human cells.
It will also be appreciated that isolated mammalian cells of the invention may be characterized by protein expression.
Protein expression can be determined using the techniques in the Examples herein and other standard protein chemistry and serology techniques such as western blotting, 2D gel electrophoresis (e.g. SDS-PAGE and isoelectric focussing), mass spectrometry, immunohistochemistry and immunofluorescence (e.g by flow cytometric analysis).
In one embodiment, the isolated mammalian cell expresses one or more of the proteins set forth in Table 6, or preferably the proteins expressed by at least 20% of isolated mammalian cells listed in Table 7 and/or wherein mean fluorescence is greater than 5000 units. Referring to Table 6, particular examples of proteins expressed by said isolated mammalian cell, wherein mean fluorescence is greater than 18000 units include: CD13; CD16/32; CD23; CD34; CD28; CD38; CD40; CD45; CD61; CD69; CD95; CDl 17; CD122; CD124; CD201 and/or CD309. In another embodiment, the isolated mammalian cell expresses one or more of OCT-3/4, SOX2 , NANOG, KLF4, MVH, KIT and NESTIN. Typically, OCT- 3/4 and SOX2 proteins appear to be less abundant than in a Reference cell such as an ES cell.
The isolated mammalian cell of the invention may include a label for detection of the cell. GFP is one example. The label may be passed on to subsequent generations so as to monitor the development and cellular fate of the progeny.
Typically the isolated mammalian cell of the invention has a diameter of about 6 to 12 micron, preferably 8 to 10 micron and defines a spherical shape in suspension culture. The diameter of the cell can be determined by microscopy or other standard methods in the art. The adherent mammalian cell defines an elongated shape, with a morphology that resembles a fibrocyte or mesenchymal cell, with variable dimensions.
An isolated mammalian cell according to the invention may be provided, produced, cultured or obtained by any of a number of processes. Advantageously, these processes do not require the use of embryonic tissues, nor do they require genetic manipulation or modification of cells or tissues.
In one embodiment, an isolated mammalian cell according to the invention is provided by culturing the one or more cells or tissues in conditions for promoting cell proliferation and self renewal. These conditions prevent the cell from differentiating. In another embodiment, the isolated mammalian cell is provided by a process including culturing one or more cells or tissues in a medium containing factors for inducing plasticity and/or inhibiting differentiation and/or for inducing proliferation.
Generally the sample is a sample of adult tissue, examples including bone marrow, central nervous system tissue, neural tissue, skin, gut, pancreas, muscle, brain, heart, adipose, olfactory mucosa or other mucosa or epithelia.
Preferably, the tissue is olfactory mucosa. Particularly preferred examples of olfactory mucosa and methods for isolation are discussed in the Examples below. Isolated mammalian cells may be cultured "directly" from primary olfactory mucosa or from neurospheres or a neurosphere-like cellular mass which is derived from primary olfactory mucosa.
In certain embodiments, the isolated mammalian cell is provided by a process including culturing neurospheres or a neurosphere-like cellular mass in a medium containing factors for inducing plasticity and/or inhibiting differentiation and/or for inducing proliferation, thereby providing the isolated mammalian cell.
A "neurosphere" is generally known in the art as a heterogenous mixture of sometimes free floating cells generated by neural stem cells in vitro. Neurospheres are understood to form because daughter neural stem cells remain attached to their mothers through many rounds of cell division. They may also form by aggregation in which some aggregates are clonal whereas others are not.
A "neurosphere -like cellular mass" is generally understood as meaning a cellular mass that has the physical characteristics of a neurosphere. However the mass is generally not just derived from a neural stem cell. A neurosphere is a heterogenous mass that contains multipotent cells (typically less than 0.5 - 1 % of total cells) plus proliferating progenation and precursom, plus differentiating progeny
(neurons and glia). Prior to the invention a neurosphere-like cellular mass was understood to be multipotent normally giving rise to neurons or glia, and not to contain pluripotent cells.
In one embodiment the neurosphere or neurosphere-like cellular mass is formed by the process discussed in Murrell et al. 2005 Dev. Dynamics 233: 496.
In another embodiment, the cell is provided by a process including:
(a) forming a neurosphere or neurosphere-like cellular mass from a sample of tissue; and
(b) obtaining the cell from the neurosphere or neurosphere-like cellular mass, thereby providing the cell.
Examples of a medium containing factors for inducing plasticity and/or inhibiting differentiation and/or for inducing proliferation are described further herein. Typically the factors that are used in the cell culture are FGF2, FGF9, leukaemia inhibitory factor (LIF) and SCF or homologues thereof that retain the functional activity of these molecules. In one embodiment SCF is provided in a form wherein it is attached to, or otherwise expressed by, a feeder layer of cells. In certain embodiments, the cell obtained from the neurosphere or neurosphere-like cellular mass or tissue sample is cultured on a feeder layer and exposed to a gelatin coated surface. Examples of these culture conditions are described further herein. Preferably, the cell is provided by a process including the following steps:
(a) forming a neurosphere or neurosphere-like mass from a sample of tissue;
(b) dissociating cells that form part of the neurosphere or neurosphere-like mass;
(c) culturing the dissociated cells on a feeder layer in a culture medium comprising one or more of the group selected from FGF2, LIF, FGF9 and/or SCF or homologues thereof; and
(d) harvesting cultured cells produced at step (c). Preferably, the culture medium is POSE medium.
Preferably, the cells are cultured in step (c) for greater than 7 days. More preferably, the cells are cultured for greater than 16 days.
In specific embodiments relating to isolated human cells of the invention, the medium may further comprise one or more of TGFβ2 or BMP4.
In one particular embodiment relating to isolated human cells of the invention, the medium comprises FGF2, LIF, FGF9, SCF, TGFβ2 and BMP4. As shown in Table 8, various combinations of some or all of FGF2, LIF, FGF9, SCF, TGFβ2 and BMP4 may be used. It is also noted that feeder cells expressing SCF (column I in Table 8) may support cell culture in the absence of any of the other factors.
In some embodiments, the RNA and/or expressed protein is analysed for expression of genes that are required for pluripotency of cells. The resulting gene expression profile can be compared to the PluriNet database to determine the genes expressed in common with those in the PluriNet database. The analysis provides information in regard to the pluripotentiality of the cells by providing information in relation to the ability of cells to form teratomas and to undergo differentiation in culture along specific differentiation pathways.
It will also be appreciated that isolated mammalian cells of the invention may be propagated and differentiated into one or more cells or tissues of interest. Differentiation may be facilitated by culture of isolated mammalian cells of the invention in suitable growth and/or differentiation factors, as are well known in the art. Non-limiting examples of such growth and/or differentiation factors include NGF, colony stimulating factors, EGF, FGF, VEGF, HGF, IGFs and the like.
By way of example only, isolated mammalian cells of the invention may be differentiated into particular cell or tissue types such as neural cells, glia, epithelial cells such as skin and corneal cells, bone marrow cells or more differentiated cell types of the lymphoid or myeloid lineages, hepatic cells, pancreatic islet cells, cardiomyocytes and other muscle cell types and endothelial cells such as vascular endothelium, although without limitation thereto. In particular, isolated mammalian cells of the invention may be differentiated into cells or tissues known to be affected in a disease or disorder. Examples of such diseases are schizophrenia, Parkinson's disease, motor neurone disease, hereditary spastic paraplegia, MELAS mitochondrial mutational disorder and Alzheimer's disease.
In certain embodiments, differentiated cells and tissues may be useful for autologous or non-autologous cell or tissue transplantation for the treatment of a disease or condition responsive to such treatment.
In certain other embodiments, these differentiated cells may be useful for identifying or screening compounds for a desired activity, such as by drug screening and identification, toxicology, pharmacological testing and the like. Accordingly the desired activity may biological, pharmacological or any other desired activity. By way of example only, desired activities may include cell growth and/or differentiation activity, anti-tumour activity, pro- or anti-apoptotic activity, neuropharmacological activity; activity in regulation of metabolism; hormonal activity; gene regulatory activity; cell cycle regulation and immunoregulatory activity.
For example candidate drug {i.e. any suitable compound) could be screened using these differentiated cells to test their toxicological or teratogenic effect. For example if a drug is being developed for treating cancer, isolated mammalian cells of the invention cells may be differentiated into corresponding normal cells. A candidate drug or other compound may then be applied to the differentiated cells (i.e normal or non-cancerous) cells to determine which drugs or compounds that act on the cancer cell line, but not on normal cells. In this manner, the drug or other compound may be added to the cancer cell line and the differentiated cells to select a drug or compound and/or dose suitable for killing the cancer cell line, but not the normal cells. In another example, isolated mammalian cells of the invention may be propagated and differentiated into a specific type of neuron (with a specific neurotransmitter profile) or glia and then drug effects and gene expression assessed. Differentiated cells may then be screened using nucleic acid expression profiling or protein expression profiling to identify nucleic acids or proteins that may be used to investigate a cause of the disorder or could be used for clinical diagnosis.
Nucleic acid and protein profiling is known in the art and may include methods such as an array, microarray and protein binding assays (e.g. ELISA and Western blot). The arrays may be nucleic acid arrays or protein arrays. A reference expression profile may be determined by profiling expression of a number of selected nucleic acids or proteins from one or more representative normal or diseased individuals (i.e. individuals having a disorder). A particular reference expression profile may be correlated with normal or diseased condition. In one embodiment, isolated mammalian cells of the invention may be propagated from a patient presenting with a particular disease, such as those mentioned above, and a nucleic acid or protein expression profile determined. This patient expression profile may be compared with a reference expression profile of an unaffected control. Such a comparison may determine a nucleic acid or protein profile correlated with a particular disease. A reference expression profile of a diseased condition may be determined once an expression profile is known that correlates with a diseased condition.
In embodiments where isolated mammalian cells of a patient are differentiated into cells of interest that are associated with a particular disease (e.g. neurons, glia), nucleic acid or protein expression of these differentiated cells may then be compared with a reference expression profile, e.g. a control or known profile correlated with a diseased condition.
Comparing an expression profile of a diseased condition with a normal control may reveal a biochemical pathway associated with the diseased condition. Such a finding may lead to a diagnostic test for that disease and may aid in defining a cause of the disease.
The reference nucleic acid or protein expression profile may comprise a variety of cell types or tissue types. The reference profiles may be purchased commercially. In general, a reference profile may comprise a "control sample" from normal tissues of developmental stages of interest, such as those available commercially or the control sample may originate from cells of a particular disorder. For example, in schizophrenia a change in gene expression is observed in post- mortem brain. A similar change in gene expression may be assessed in cells available from a skin biopsy. A comparison may be made between fibroblast cell from skin, olfactory tissue biopsies and isolated and propagated olfactory stem cells. All these samples may be compared with commercially available reference profile (s) or a unique reference profile may be discovered which may be compared with future samples for research or diagnostic purposes.
When assessing genetic fingerprints of disease it may not be necessary to differentiate the isolated mammalian cells of the invention uniformly into a specific cell type and a heterogeneous population of neurons and glia that are reproducibly presented in control and disease cultures may be sufficient to compare gene expression. Alternatively, if a particular neuron type is suspected to be affected in a disease the isolated mammalian cells may be differentiated into a single cell type.
The method described above does not require assaying for a previously known nucleic acid or protein. As will be appreciated by a person skilled in the art, a comparison between expressed nucleic acids or proteins of a test cell and a known normal and/or diseased cell may provide information in relation to the test cell being normal or diseased (i. e. associated with a disorder).
It will be appreciated that toxicity or teratogenicity of a drug or other compound may be assessed as described above. Toxicity or teratogenicity of a compound may be determined by abnormal or a change in behavior of the isolated mammalian cell and/or differentiated cell therefrom. For example, abnormal or changed behaviour may include a change when compared with control non-disease cultures or control non-compound exposed cultures. Such changes include: cell death rate, cell division rate, proliferation rate, differentiation fate or abnormal differentiation, a change in morphology (perhaps due to cytoskeletal deficits), a changes in nuclear repair mechanisms such as in response to ionising radiation or a change in gene expression or protein expression. A person skilled in the art would be able to consider other changes in cell behaviour. In one embodiment, there is provided an isolated mammalian cell of the invention, or a cell differentiated therefrom as hereinbefore described, transformed or transfected with an isolated nucleic acid, referred to herein as a "genetically- modified cell of the invention". In one preferred embodiment, the isolated nucleic acid encodes a therapeutic agent, such as a therapeutic protein or therapeutic nucleic acid. Examples of therapeutic nucleic acids include RNA molecules, as wil be described in more detail hereinafter.
In one particular embodiment, the isolated nucleic acid is, or is provided in, a genetic construct, such as an expression vector or construct.
Suitably, the genetic construct comprises said isolated nucleic acid operably linked or connected to one or more additional nucleotide sequences. In certain embodiments additional nucleotide sequences may be regulatory sequences that facilitate and/or control expression of said nucleic acid. Non-limiting examples include promoters, enhancers, repressors, polyadenylation sequences, introns and/or splice donor/acceptor sequences, although without limitation thereto.
Promoters operable in mammalian cells are well known the art. The promoter may be constitutive, regulatable (Le inducible or repressible), tissue specific or subject to other desired functional constraints or influences on promoter activity. By way of example only, the promoter may be any promoter useful for mammalian expression, including but not limited to a CMV promoter, an SV40 promoter, an elongation factor α promoter (e.g. pEF-BOS), a crystallin promoter (e.g. αA crystallin, β2 crystallin) or a hybrid promoter (e.g. SRa), for example.
Other embodiments of additional nucleotide sequences may be selection marker sequences to facilitate selection of stable transformants/transfectants (e.g by providing resistance to neomycin, geneticin etc., or susceptibility to gangcyclovir, for example). Yet further additional nucleotide sequences may include sequences that facilitate homologous recombination, inclusive of gene "knock out" or "knock in" sequences such as Cre, loxP and/or FLP recombinase sequences. Isolated mammalian cells of the invention, or differentiated cells, may be transfected or transformed with a genetic construct, such as an expression vector or construct comprising a nucleic acid of interest. It will be appreciated that any suitable means for delivering a nucleic acid into a cell may be used, for example transfection or transformation such as by electroporation, calcium phosphate precipitation, cationic lipid delivery, DEAE dextran or other methods known in the art.
The construct or vector may be integrated into the genome of the isolated mammalian cell, or alternatively may be maintained extra-chromosomally. The nucleic acid may encode a protein or another molecule such as an RNA molecule, such as a therapeutic protein or RNA (e.g. an interfering RNA, microRNA, snoRNA, piRNA, ncRNA or a ribozyme). These RNA molecules may have a role in cellular activities including tumour suppression, regulation of transcription and/or of translation and/or regulation of the cell cycle, or of regulation of apoptosis. Proteins encoded by the nucleic acid may be hormones, cytokines, growth factors, neurotransmitters, enzymes, antibodies, immunogenic and/or antigenic proteins, although without limitation thereto. The protein may be a gene regulatory protein such as a transcription factor, repressor or other DNA-binding protein, or a protein that induces epigenetic changes in chromatin structure. Examples include but are not restricted to: histone modifiers (acetylases, deacetylases, DNA methyltransferases).
In some embodiments, the nucleic acid may correspond to an "endogenous nucleic acid" normally expressed by the cell, or a fragment thereof, or may be homologous to an endogenous nucleic acid. By way of example only, the construct or vector may comprise an endogenous nucleic acid that corresponds to a defective or mutated nucleic acid of a recipient. Accordingly, expression of the nucleic acid and/or encoded protein may treat a disease present in the recipient caused by the mutated or otherwise defective endogenous nucleic acid of the recipient. Genetically modified cells of the invention may be suitable for delivering therapeutic agents to a mammal to thereby treat a disease or condition.
In one particular example, the nucleic acid may enable said genetically modified cell of the invention to express a secreted protein such as a hormone, growth factor or cytokine, or biologically active fragment thereof. Expression of these proteins may have therapeutic benefit. By way of example only, these include: insulin for treating diabetes; thyroxine for treating hypothyroidism; and/or treatment of the nervous system such as by expressing dopamine or GDNF for Parkinson's Disease or acetylcholine to treat Alzheimer disease. In brain and spinal cord regeneration other growth factors might be useful such as BDNF, NGF, NT3.
Accordingly, in other aspects the invention provides compositions, methods and/or uses of one or more isolated mammalian cell according to the invention, and/or one or more cells differentiated therefrom, for treating a disease or condition in a mammal. Such treatments may be prophylactic or therapeutic, as required.
In one particular embodiment there is provided a composition, methods and/or uses of an isolated mammalian cell according to the invention, and/or one or more cells differentiated therefrom, for autologous or non-autologous cell transplantation for the treatment of a disease or condition.
Compositions of the invention may comprise one or more of said cells together with a carrier, diluent, excipient or preservative.
Preferably, the composition is a pharmaceutical composition. The pharmaceutical composition suitably comprises a pharmaceutically-acceptable carrier, diluent or excipient. By "pharmaceutically-acceptable carrier, diluent or excipient" is meant a solid or liquid filler, medium, diluent or encapsulating substance that may be safely administered to a mammal, such as a human- Depending upon the particular route of administration, a variety of carriers, well known in the art may be used. These carriers may be selected from a group including sugars, starches, phosphate buffered solutions, emulsifiers and isotonic saline.
Any suitable route of administration may be employed for providing a patient with the pharmaceutical composition of the invention. For example, intravenous, intra-articular, intra-muscular, intra-dermal, subcutaneous, intraperitoneal, surgically implanted and the like may be employed. In a preferred form, the pharmaceutical composition is administrable to a specific site by surgical implantation. Non-limiting examples include compositions administrable at a site of a spinal injury, as bone marrow for reconstitution in immune compromised patients, as heart muscle for regeneration in cardiac patients, as pancreatic β cells for diabetics, or as neural tissue for treating brain injury or degeneration. For example, cells may be administered into either the caudate nucleus or the substantia nigra for dopamine neuron replacement in treating Parkinson's disease patients. A predetermined dosage form includes dispersions, suspensions, injections, solutions and the like. Dosage forms may also include implants, matrices, microcapsules, prostheses, gels, controlled-delivery devices, osmotic pumps and the like. Pharmaceutical compositions of the present invention suitable for administration may be presented as discrete units such as vials containing a predetermined amount of one or more cells of the invention, as a solution or a suspension in an aqueous liquid or a non-aqueous liquid. Such compositions may be prepared by any of the methods of pharmacy, but all methods include the step of bringing into association one or more cells as described above with the carrier which constitutes one or more necessary ingredients.
It may be possible to treat several diseases using cells of the present invention. For example, stem cells obtained from a biopsy of human donor having the CCR5 allele may confer resistance to HIV infection (Samson et al., 1996, Nature 382 722, incorporated herein by reference). Cells may be transplanted into a patient infected with HIV to prevent or reduce progression of AIDS. Alternatively, cells may be transplanted into a non-infected patient to confer immunity or resistance to HIV infection. Similar methods may be used to genetically modify a cell propagated in accordance with the methods of the invention such that the propagated cells express any nucleic acid of interest. Using the cells of the invention, several diseases may potentially be treated, for example, nerve injury, spinal injury, schizophrenia, Parkinson's disease, Alzheimer's disease, bipolar disorder, mitochondrial disorders, epilepsy, diabetes, kidney failure, neuro-degenerative diseases, plastic anemia, immune-deficiency diseases, autoimmune diseases, cancers including lymphomas and leukemias, sickle cell anemia and osteoporosis deficiency in expression of a protein.
The cells of the invention may be useful for treating genetic defects. For example, U. S. Pat. No. 5,760, 012 (incorporated herein by reference), describes methods to genetically modify hematopoietic stem cells in patients afflicted with hemoglobinopathies such as sickle cell anemia, beta-thalassemia, or Gaucher's Disease. Methods of treating sickle cell anemia are disclosed by Cole-Strauss, A., et al., 1996, Science, 273 1386, incorporated herein by reference. In particular embodiments, genetically modified cells of the invention may express an antibody or an antigen. For example, the genetically modified cell of the invention may be differentiated into a "dendritic cell" (DC) for use in dendritic cell therapy. DCs are antigen presenting cells capable of initiating an antigen-specific T- cell response in an animal. DCs may be isolated from various locations of an animal's body, including peripheral blood, however, it may be difficult and laborious to isolate and propagate DCs from blood. Alternatively, DC precursors may be propagated. For example, a DC precursor may be propagated and expanded in accordance with the methods of the present invention so that a suitable number of cells may be cultured for use in dendritic cell therapy. A isolated mammalian cell may be differentiated into a predetermined stage of development suitable for dendritic cell therapy.
"Dendritic cell therapy" refers to therapeutic cancer vaccines or cellular vaccines used for tumour immunotherapy as a method for treating cancer. Dendritic cell therapy typically involves isolating DC from a patient (or isolating propagating the DC precursor), culturing the isolated DC in the presence of a tumour-associated antigen or transfecting the isolated DC with a nucleic acid encoding a tumour- associated antigen ("antigen loading or pulsing"), and administering the antigen loaded or transfected DCs to the patient. Methods for loading or pulsing dendritic cells with an antigen are described in (Meidenbauer et al, 2001, Biol Chem 4 507; Rains, et al, 2001, Hepatogastroenterology 38 347; Nestle, 2000, Oncogene 56 6673; Gilboa & Lyerly, 1998, Cancer Immunotherapy 46 82).
By way of example, US Patent 5,788, 963, describes methods and compositions for use of human dendritic cells to activate T-cells for immunotherapeutic responses against primary and metastatic prostate cancer. In one embodiment isolated DC are exposed in vitro to a prostate cancer antigen before administration to a patient.
Isolated mammalian cells may be used with a patient undergoing high dose chemotherapy and/or radiation therapy. Prior to chemotherapy, a neural tissue biopsy may be performed on a patient and the stem cells expanded in vitro in accordance with the invention and stored. The stem cells may be genetically modified or not after biopsy. The cells may later be infused into the patient after the chemotherapy treatment. Isolated mammalian cells of the invention may undergo spontaneous or induced immortalisation in vitro. The resulting immortalised, clonal or non-clonal cells may be useful as a cell line that may be genetically manipulated or not. The cell line may be placed in conditions that induce or do not induce, lineage commitment in vitro or in vivo and/or undergo cell differentiation or not, in vitro or in vivo.
Isolated mammalian cells of the invention can be used for basic research to understand the fundamental biology of development, including genes, growth factors and nutrients, which direct cellular and tissue formation. Examples of typical methods that may be used with cells prepared in accordance with the present invention are well known in the art.
Accordingly, one particular aspect of the invention provides a method of producing a non-human mammal, said method including the steps of:
(a) delivering one or more isolated mammalian cells of the invention to a blastocyst of a non-human mammal; and (b) producing one or more progeny from said blastocyst.
Suitably, the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
Preferably, the method further includes the step of implanting or otherwise transferring the blastocyst produced at step (i) to a female non-human mammal.
Suitably, the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
It will be appreciated that "progeny" include and encompass immediate offspring and the progeny of subsequent generations.
One particular embodiment includes producing a genetically-modified non- human mammal. For example, one or more genetically-modified mammalian cells, as hereinbefore described, may be delivered to the blastocyst of the non-human mammal at step (i). Subsequent "transgenic" progeny may be bred which include the genetic modification of the cell delivered at step (i).
A non-human mammal (e.g. a mouse or rat) produced according to the invention, inclusive of genetically-modified non-human mammals, may be useful for drug screening, analysis of developmental gene expression and identification of candidate molecules having a desired biological activity, such as by high-throughput screening, although without limitation thereto. The desired biological activity may include cell growth and/or differentiation, anti-tumour activity, pro- or anti-apoptotic activity, cell cycle regulation and immunoregulatory activity, although without limitation thereto.
Isolated mammalian cells of the invention may be used with a known animal model of disease to assess cell replacement therapy.
These animal models include: (A) neurobiology and disorders thereof, in all of its manifestations, including: Alzheimer's disease, Amyotrophic lateral sclerosis, Huntington's disease research tools for neurobiology, spinal cord injury, spinal cord disease, multiple sclerosis, cerebral palsy, muscular atrophy, (B) cardiovascular biology and disorders thereof, in all of its manifestations including myocardial infarction, stroke, ischemia, (C) epilepsy in all of its manifestations, (D) reproduction and disorders thereof, in all of its manifestations, (E) endocrinology and disorders thereof, in all of its manifestations, including Diabetes Mellitus Type I and Type II, (F) sensorineural development and function and disorders thereof, in all of its manifestations, (G) immune deficiency in all of its manifestations, (L) inflammation in all of its manifestations, (H) vital organ development and function and disorders thereof, in all of its manifestations, (I) dermatology and disorders thereof in all of its manifestations, (J) lung and respiratory tract development and function and disorders thereof, in all of its manifestations, (K) apoptosis and disorders thereof, in all of its manifestations, (L) cancer in all of its manifestations, (M) cell biology and disorders thereof, in all of its manifestations, (N) developmental biology and disorders thereof, in all of its manifestations, (O) haematology and disorders thereof, in all of its manifestations, (P) rodent/human gene homologs / orthologs, and mutants thereof, in all of their manifestations, (Q) metabolism and disorders thereof, in all of its manifestations.
The following non-limiting examples illustrate the isolated mammalian cells, compositions and methods of the invention. These examples should not be construed as limiting: the examples are included for the purposes of illustration only. The pluripotent olfactory stem "pOS" cell discussed in the Examples will be understood to represent an exemplification of the isolated mammalian cell of the invention.
EXAMPLES Production and characterization of a murine pluripotent olfactory stem "pOS" cell
Generation of murine pOS cells
Olfactory mucosa was dissected from adult, transgenic Rosa-EGFP mice (Quah et al., 2008, Proceedings of the National Academy of Sciences of the United States of America 105, 4259) and the cells grown in serum-free medium with EGF and FGF2 to form neurospheres in order to select for a cell population that includes a multipotent, neural stem cell (Murrell et al, 2005, Dev Dyn 233, 496; Murrell et al, 2008, Stem cells (Dayton, Ohio) 26, 2183)
Neurosphere-derived cells were dissociated and grown on a feeder layer of mouse stromal cells expressing a membrane-associated form of mouse Stem Cell Factor (SCF; Matsui et al., 1992, Cell 70 841) in a medium containing FGF2, SCF, FGF9, and Leukemia Inhibitory Factor (LIF). After 2 weeks, fluorescence-activated cell sorting (FACS) of these cultures revealed three populations of cells based on their EGFP expression: bright, dim and negative (Fig. IA). After a further week, EGFP expression was lost completely (Fig. IB). Prior to FACS these EGFP-negative cells were relatively homogeneous and non-differentiated in appearance (Fig. 1C) and after sorting they were small and round and about 10 μM in diameter (Fig. ID). EGFP-dim and EGFP-negative cells (pOS cells) were selected for blastocyst injection; some were frozen and stored beforehand (Fig. IG). The EGFP-bright cells were of mixed, more complex morphologies and were not selected for blastocyst injection.
Generation of chimeric mice from pOS cells and of Fl from chimerics pOS cells were injected into syngeneic C57BL/6 blastocysts (3.5 d.p.c.) which were then implanted in pseudo-pregnant CD-I females. Chimeric embryos and neonates were identified by the presence in their tissues of the EGFP transgene identified using qPCR or PCR of DNA from tissue samples of tail, limb-bud or liver (Fig. IE, F; Supplementary Fig. 1). Chimeric mice were generated in 5 out of 6 series of blastocyst injections (Fig. IG). In the initial experiments EGFP-dim cells were selected and 15-18 or 20-25 cells were injected into each blastocyst. This produced 18 live born pups, 9 of which were chimeras (Fig. IG). Six of these chimeric founders (3 F, 3M) were bred with wild-type C57BL/6J mice to test for germ-line transmission. Of these, 3 females and 2 males were transgenic, producing 41 offspring, 26 of which were transgenic, identified by qPCR of DNA (Fig. IE and IF) or immunochemistry of tissues (Fig. 2J-N). A transgenic male offspring of a chimeric female founder was bred to produce a second generation of 11 pups, 7 of which were transgenic. Transgenic offspring expressed EGFP throughout their tissues (Figure 2 J and Figure 4).
For the next series of experiments, a new population of pOS cells was generated from a second culture preparation. This time, culturing for an extra week produced EGFP-negative pOS cells (Fig. IB-D), 15-18 of which were injected per blastocyst, producing 39 offspring; 22 were chimeric (Fig. IG). pOS cells were able to be frozen and thawed. The proportion of chimeras was similar whether the pOS cells were taken from fresh cultures or thawed from frozen aliquots of those same cultures (Fig. IG). Taken together these results demonstrate that the pOS cells robustly and repeatedly gave rise to chimeric mice after blastocyst injection. Significantly, we demonstrated germline chimerism in 5 of these chimeras of both sexes and demonstrated passage of the EGFP transgene through two subsequent generations.
As a more stringent test of pluripotency, we injected blastocysts with single pOS cells (Fig. IG). This generated 15 chimeras from a total of 15 embryos (Fig. IG), identified by qPCR for the EGFP transgene in fetal limb bud samples. The tissues of chimeric animals were demonstrably chimeric for the EGFP transgene identified immunochemically at 13.5 d.p.c. Organs from all embryonic germ layers were EGFP-positive in some embryos (Fig. 2A-C; Fig. 5). Negative controls included EGFP-containing tissues without primary antibody (Fig. 2D-F) and wild- type, non-EGFP tissues processed for immunochemistry with the primary antibody (Fig. 2G-I). These single pOS cells were previously frozen, stored and thawed before blastocyst injection (Fig. IG). These results revealed that the progeny of a single cell are capable of proliferation and contributing to multiple tissues of all germ layers in the chimeric offspring.
Assessment of chimerics and Fl for abnormalities and tumours
There were no abnormalities observed in any of the chimeric embryos and the live born chimeric pups were healthy and otherwise indistinguishable from their non- chimeric littermates. None of the 48 chimeras had any obvious tumours. Adult chimeric mice and their offspring were healthy and fertile. Thirteen chimeras were maintained until 14 months old without evidence of any tumours. Independent veterinary pathology analysis revealed no pathologies in any mice except those associated with normal ageing in this strain. Similarly, no tumours were observed in pathological analysis of the first and second generation offspring of the chimeric mice at 6 -12 months of age (n = 10). These results demonstrate that germline chimerism of pOS cells is not associated with the unrestrained growth associated with tumour formation in chimeras or their offspring.
Assessment of teratomas formation by murine pOS cells
The developmental potency of stem cells is often evaluated by their ability to form teratomas when injected into immune deficient mice. Pluripotency demonstrated by teratoma formation is taken as a marker for pluripotency (Okita et al., 2007, Nature 448 313; Takahashi et al., 2007, Cell 131 861; Thomson et al, 1998, Science 282 1145). The ability of pOS cells to form teratomas was assessed by subcutaneous injection of 100,000 cells into each of two sites per mouse (n=3). The injected pOS cells were from the same batch that produced chimeric mice. None of the 6 injection sites showed any tumours or teratomas during the 4 month period of observation. Independent veterinary post-mortem and pathological inspection revealed no tumours in any part of the body. These results suggest that pluripotency defined by teratoma formation and germline chimerism can be dissociated.
Gene expression in murine pOS cells
Several genes are thought to be essential for pluripotency in embryonic stem cells (ES cells). These include Nanog, Oct3/4, Sox2, Myc, and Klβ4 (Yamanaka, 2007 Cell stem cell 1 39). Remarkably, retroviral insertion of the latter 4 genes was able to induce pluripotency in adult fibroblasts (Takahashi & Yamanaka, 2006, Cell 126 663). These "induced pluripotent stem cells" (iPS cells) are germline competent (Okita et al., 2007 supra) and were recently generated without viral vectors (Okita et al., 2008, Science 322 949).
Preliminary analysis of pOS cells indicated that they did not express Ocύ/4 or Sox2, although they robustly expressed Myc and Klf4 and only very low levels of Nanog (Fig. 6). It was therefore of interest to compare the transcriptome of pOS cells with other pluripotent cells, to seek a deeper understanding to the lack of expression of such "essential" pluripotency genes as Oct3/4 and Sox2( Kim et al., 2008, Nature 454 646). Whole transcriptome analysis was undertaken to compare cells at different stages of pOS cell generation: neurosphere-derived cells (Reference cells), EGFP- dim and EGFP-bright (FACS selected but not injected). Overall, the EGFP-bright cells were more similar in gene expression to the Reference cells, with an increasing trend to homogeneity of expression in EGFP-dim and EGFP-negative pOS cells (Fig. 3A).
Comparison of gene expression in the different cell populations generated a list of genes whose expression was increased in the pOS cell population compared to the Reference population (Table 1). A recent study (Muller et al., 2008, Nature 455 401) compared the transcriptome of 150 pluripotent and non-pluripotent cell lines to define a regulatory network of genes that is shared by pluripotent human cells (ES cells, embryonal carcinomas and iPS cells). This "pluripotency network" (PluriNet) included Nanog and the iPS genes as well as many genes regulated by Oct3/4 and Sox2, but also included many genes outside these better studied regulatory pathways. The existence of a "pluripotency network" of gene regulation (rather than just a few regulatory genes) may help explain how pOS cells are pluripotent by one measure (germline chimerism) but not another (teratoma and tumour formation). This was tested by comparing the list of genes enriched in pOS cells (Table 1) and the list of genes in the pluripotency network (Muller et al., 2008, supra) to derive a list of PluriNet genes expressed in pOS cells (Table 2). Of the 299 PluriNet genes, 273 were represented on the mouse array, of which 166 were detected in pOS cells, and 49 were significantly enriched (pO.Ol) in the pOS cells compared to the original neurosphere population (Reference cells). Taking into account the number of probes on the microarray (24,620), the number of genes expressed by the pOS cells (7,475) and the number of mouse genes in the pluripotency network (273), the probability of finding 166 PluriNet genes expressed by pOS cells by chance was very small (p=l.l le-25, Fisher's exact test). This demonstrates that, while pOS cells share a significant number of pluripotency genes with other pluripotent cells, they do not share the full complement, just as they do not share the full phenotype that includes teratoma and tumour formation. The gene expression analysis confirmed the preliminary qPCR analysis in detecting mRNAs for Klf4 and Myc, but not Oct3/4 and Sox2, genes thought central for pluripotency in iPS cells (Kim et al., 2008, supra). Nanog mRNA was detected at low levels in EGFP-dim pOS cells but not in EGFP-negative pOS cells. Notably, OCT-3/4, SOX2 and NANOG proteins were detected in vitro by immunofluroescence in some clusters of pOS cells (Fig. 3C), indicating that a minority of cells (10%) retained these proteins while their mRNA was undetectable in the pOS cell population (Fig. 3C). Therefore, the high rate of chimerism (66%) after blastocyst injection of single pOS cells indicates that ongoing expression of Nanog, Sox2 and OcU/ 4 may not be required for pluripotency and germline competence, although they may initiate the process. Alternatively, these genes may be induced in pOS cells after they are injected into blastocysts and are exposed to the local milieu. This seems paradoxical given their importance for pluripotency in iPS cells but it is consistent with their transient induction of pluripotency in iPS cells without on-going expression (Okita et al., 2008). We examined this hypothesis indirectly by investigating the expression of genes that are connected to a subnetwork of the PluriNet in which Oct3/4, Sox2 and Nanog are responsible for chromatin modification (Fig. 3B). Low or absent expression of Oct3/4, Sox2 and Nanog were linked with low levels of expression of protein-partners and adjacent network members in pOS cells whereas the chromatin modifiers Myc, Kl/4/5, HDACl and their partners were induced in pOS cells, as were the cell cycle subnetworks associated with PluriNet (Muller et al., 2008, supra).
Murine pOS Cell culture Olfactory neurosphere cultures were prepared from olfactory mucosa
(Murrell et al., 2005, supra) from adult male Rosa-EGFP transgenic (Quah et al., 2008, supra). Neurospheres were grown for 7-8 d in a serum-free medium containing EGF and FGF2 then harvested by trypsin digestion and grown for a further 2 d as single cells. They were then dissociated and plated in flasks, pre-coated with a solution gelatin, and seeded with a confluent monolayer of freshly-thawed, immortalised, S7/S74-mSCF220 mouse stromal cells that were mitotically inactivated. The cells were grown at 37C and 5% CO2 in humidified air in pOS enrichment (POSE) medium. After 8 d the cells were harvested by trypsin digestion and grown for 2 passages on gelatin-coated flasks without feeders, and harvested at 70-80% confluence by trypsin digestion. Trypsin was inactivated by the addition of surplus POSE medium. pOS cells were analysed and sorted using a BD FACSVantage SE DiVa Cell Sorter according to levels of EGFP fluorescence.
Blastocyst injection, embryo transfer and detection of EGFP in chimeras and transgenic offspring
Blastocysts were harvested at 3.5 days post coitus (dpc) after mating wild type, adult C57BL/6J females and males. Single or multiple GFP-dim or GFP- negative populations of pOS cells, selected by FACS were injected into blastocysts after which they were placed within the oviduct (0.5 dpc,) or the anterior uterine horn (2.5 dpc) of pseudopregnant CD-I female mice, that were mated with vasectomised CD-I males (Nagy et ah, Manipulating the mouse embryo: a laboratory manual, 3rd ed. (Cold spring Harbor Laboratory Press, Cold Spring Harbor, 2003)). Chimerism was detected in embryos harvested at 13.5 or 16.5 dpc and in neonatal pups by analysing DNA from tail, foetal liver or limb bud tissue, using quantitative, real-time polymerase chain reaction (qPCR). Some chimeric pups were grown to adulthood and mated with adult C57BL/6J mice to test for germ-line transmission of the EGFP transgene to produce transgenic offspring. These were identified by detection of EGFP using qPCR genotyping. Chimeric and transgenic embryos were also analysed for EGFP protein expression using immunofluorescence.
Teratoma formation
In three animals 100,000 pOS cells were injected subcutaneously at two sites in immune deficient NOD. CB 17 -Pr kdcscι mice. Mice were examined weekly and underwent a detailed post-mortem 4 months later.
Gene expression profiling
Cells were analysed for their gene expression at different stages of the culture process: reference cells, prior to growing in POSE medium (dissociated neurosphere- derived cells grown in FGF2 and EGF); after 8 d in POSE medium, prior to FACS sorting; after FACS sorting as EGFP-bright and EGFP-negative. Purified RNA was hybridized to the Illumina Mouse-Ref8 vl.l BeadChip (Illumina, Inc.). Genes were identified that were enriched in the pOS cells (EGFP-negative) compared to the reference cells using a a series of stringent statistical criteria (see Example 23). For comparative purposes with human-mouse translation tables were built using Orthology tables at NIH DAVID (http://david.abcc.ncifcrf.gov/; Dennis et al, 2003, Genome biology 4 P3).
Mice
Donor mice were adult male Rosa-EGFP Tg (EGFP-Tg) mice, 15 weeks old. The mice were generated by crossing a Rosa26 stop/flox-EGFP mouse (kindly provided by Martyn Goulding, Department of Neurobiology, SaIk Institute, University of California at San Diego, La Jolla, CA) with a generalized Cre recombinase-expressing mouse TNAP Cre, to activate expression of EGFP (Clarke et al., 2000, Science 288 1660). Blastocysts were obtained from naturally-mated adult female C57B16J mice, 7-12 weeks of age. Outbred wild type CD-I, inbred, wild type C57BL/6J and immune deficient NOD.CB 11-Prkdcscid mice were purchased from the Animal Resources Centre, Canning Vale, Western Australia. All mice were maintained in specific pathogen free barrier conditions at all times. All experiments were performed with approval of the Animal Ethics Committees of Griffith University and the University of Queensland in accordance with the guidelines and recommendations of the National Health and Medical Research Council of Australia.
Olfactory mucosa cultures
For each experiment five mice were killed with CO2 and olfactory neurosphere cultures were prepared as described previously (Murrell et al., 2005, Dev Dyn 233, 496). The olfactory mucosa was removed from the nasal septum and placed in ice cold Dulbecco's modified Eagle's medium /HAM F12 (DMEM/F12 ; GIBCO- Invitrogen) supplemented with 10% Foetal Bovine Serum (Bovogen, Australia) and 50 U/ml penicillin and 50 μg/ml streptomycin (GIBCO-Invitrogen). After washing twice in Hank's buffered salt solution (HBSS; GIBCO-Invitrogen), the olfactory mucosa was incubated with Dispase II (2.4U/ml; Roche) for 45 minutes. The olfactory epithelium was isolated from lamina propria under the dissection microscope and both tissues were washed separately in HBSS. The lamina propria was further digested with Collagenase I (Sigma- Aldrich) for 10 minutes and gently triturated. The cells were washed with HBSS. In the mean time, the olfactory epithelium was gently triturated to break sheets of tissue into cells and washed with HBSS. The cell pellets resuspended in DMEM/F12 supplement with 10% FBS and 50U/ml Penicillin and 50μg/ml streptomycin and cultured together in a 6-well tissue culture plate (Nunc) in 5% CO2 at 37°C. The cells were passaged using 0.25% trypsin n 0.02% EDTA (GIBCO-Invitrogen) and seeded onto poly-L-lysine (0.85μg/cm2; Sigma) coated 6-well tissue culture plates (Nunc) in DMEM/F12 supplemented with Insulin, Transferrin and Sodium Selenite (ITS; GIBCO- Invitrogen), 50 ng/ml Epidermal Growth Factor (EGF; Chemicon) and 25 ng/ml Fibroblast Growth Factor 2 (FGF2; Chemicon) to generate neurospheres. After 7-8 days, the neurospheres were collected. They were incubated with ImI of TrypLE (GIBCO-Invitrogen) for 10 minutes to dissociate the spheres. The cells were washed once in DMEM/F12 and cultured in DMEM/F12 supplemented with ITS, 50ng/ml EGF and 25ng/ml FGF2 for 48 hours before culturing in POSE medium (see below).
Enrichment of pOS cells from adherent neurospheres
Medium was aspirated from cultures containing confluent neurospheres. Cells were detached from the poly-L-lysine substratum by digestion with 0.25% trypsin- EDTA in HBSS (5 mins; 37C; 5% CO2 in humidified air). Trypsin was inactivated by the addition of surplus pOS enrichment (POSE) medium (Dulbecco's modifed Eagle's medium containing 4.5 g L-glucose/mL (Invitrogen), and supplemented with 20% (v/v) heat-inactivated (56C; 30 mins) foetal bovine serum (Cambrex), 2 mM Glutamax-1 (Invitrogen), 20 units penicillin/mL: 20 ug streptomycin /mL (Invitrogen), 50 ug gentamicin/mL (Invitrogen), 30 uM adenosine (Sigma-Aldrich), 30 uM cytidine (Sigma-Aldrich), 30 uM guanosine (Sigma-Aldrich), 10 uM thymidine (Sigma-Aldrich), 30 uM uridine (Sigma-Aldrich), 1,000 units ESGRO murine Leukemia Inhibitory Factor (LIF)/mL (Millipore), 40 ng recombinant murine Stem Cell Factor (SCF)/mL (Millipore), 20 ng recombinant human FGF2/mL (Millipore), 25 ng recombinant human FGF9/mL (Sigma-Aldrich), and 0.1 mM 2- mercaptoethanol (Sigma-Aldrich)). Cell clumps were disaggregated by gentle, repeated pipetting. Cell suspensions were transferred to polypropylene tubes and centrifuged (1,000 x g; 5 mins; 4C). Medium was aspirated. Cell pellets were dislodged by gently tapping the tubes. Cells were resuspended in fresh POSE medium and plated at 40% - 50% confluence in ventilated tissue culture-grade flasks, pre-coated with a solution of 0.1% (w/v) gelatin type A (Sigma- Aldrich), and seeded with a confluent monolayer of freshly-thawed, immortalised, Sl/Sl 4-mSCF220 mouse stromal cells (a kind gift from Prof. B. Hogan, Duke University), that were mitotically inactivated by incubation in 10 μg Mitomycin C (Sigma- Aldrich M-4287) / mL POSE medium, minus LIF, SCF, FGF2 and FGF9, (3 hrs; 37C; 5% CO2 in humidified air). Culture medium was replaced daily. Cells were passaged every two days and seeded into sterile flasks, pre-coated with gelatin and seeded with freshly- thawed, mitotically-inactivated feeders. The culture medium caused feeders to detach from the gelatin substratum, and so were replenished every passage (every 2 days). When sufficient pOS cells were generated for blastocyst injections or tumour studies, pOS cells were pre-plated onto gelatin without feeders for 2 passages. Short-term culture without feeders did not appear to compromise pluripotency, as indicated by FACS, microarray, and qPCR data.
FACS analysis and sorting
Cells were pre-plated for 2 passages on 0.1% (w/v) gelatin-coated flasks without feeders, and harvested at 70-80% confluence by trypsin digestion. Trypsin was inactivated by the addition of surplus POSE medium. Between 5xlO5 and IxIO6 cells were deposited into each 5 mL, polystyrene round-bottomed tube (Becton Dickinson BD352054), and centrifuged (1,000 x g; 5 mins; 4C). Supernatants were aspirated and cells washed once in PBS containing 2% (v/v) heat-inactivated FBS (1,000 x g; 5 mins; 4C). Cells were resuspended in 0.5 mL - 1 mL PBS/2% FBS and maintained on ice when not in use. Cells were analysed and sorted using a BD FACSVantage SE DiVa Cell Sorter. EGFP fluorescence was detected using a Coherent Innova 7OC argon laser at 488 nm wavelength.
Blastocyst injection and embryo transfer Wild type, adult C57BL/6J females (7-12 weeks of age), in oestrus, were naturally mated with adult C57BL/6J males (8-24 weeks of age). The morning after the mice were paired, females were examined for the presence of a copulatory plug. Noon on the day of the plug was designated 0.5 days post coitus (dpc). At 3.5 dpc, plug-positive females were euthanased by cervical dislocation or CO2 overdose. Uterine horns were resected and blastocysts harvested by flushing with FHM (Specialty Media). Blastocysts were transferred to a dish containing KSOM-AA medium (Specialty Media) and incubated for 2-3 hrs (37C; 5% CO2 in humidified air). Immediately before microinjection into blastocysts, pOS cells were harvested and FACS-sorted. EGFP-dim or EGFP-negative populations were collected in PBS/2% FBS, washed, resuspended in POSE medium and placed on ice prior to blastocyst injection.
Blastocysts were removed from the incubator, transferred to a dish containing FHM medium and pOS cells. The dish was placed on a cooling stage set to 14C attached to a DM-IRB inverted microscope (Leica) fitted with DIC objectives and microinjectors (Narishige). Single or multiple pOS cells were injected into each blastocyst, as described elsewhere. Following microinjection, blastocysts were washed through KSOM medium and incubated in KSOM medium (37C ; 5% CO2 in humidified air) for 1 hr or until blastocysts re-expanded. Blastocysts were placed within the oviduct (0.5 dpc,) or the anterior uterine horn (2.5 dpc) of pseudopregnant CD-I female mice, that were mated with vasectomised CD-I males. CD-I females were placed under general anaesthesia during embryo transfers, as described in Nagy
DNA isolation and QPCR genotyping
Tail, foetal liver or limb bud tissue was digested in a solution containing 50 mM Tris-HCl (pH 7.6) (Sigma- Aldrich), 100 mM Na2EDTA (Sigma- Aldrich), 100 mM NaCl (Sigma- Aldrich), 1% (w/v) sodium dodecyl sulfate (Sigma- Aldrich) and 0.4 mg Proteinase K (Roche) / mL. Tissue was incubated at 55C for 16 hours. Genomic DNA was then extracted by the addition of 0.5 vol. of Tris-buffered phenol (Fluka) biopsies plus 0.5 vol. chloroform :isoamyl alcohol (24:1) (Fluka). The organic and aqueous phases were mixed thoroughly by inversion, then centrifuged (12,000 x g; 15 mins; room temp.). The upper, aqueous phase minus the interface, was transferred to a clean tube. An equal volume of chloroform:isoamyl alcohol (24:1) was added to the aqueous solution, mixed by inversion, and centrifuged as before. The upper, aqueous phase was transferred to a clean tube and residual isoamyl alcohol allowed to evaporate. An equal volume of isopropanol was added to each tube, shaken thoroughly, and centrifuged (12,000 x g; 20 mins; room temp.). The supernatant was aspirated. Nucleic acid was rinsed with 70% EtOH and centrifuged for 5 mins. Ethanol was aspirated and residual moisture evaporated by incubating tubes at 37C for 10 mins. DNA was resuspended in TE buffer (10 mM Tris-HCl (pH 7.6): 1 mM EDTA), incubated at 37C for 1 hr, and then stored at 4C. QPCR forward and reverse primers (Sigma-Aldrich) were designed to anneal within the same exon FoxL2 FP 5'GCTACCCCGAGCCCGAAGAC3• (SEQ ID NO:1) FoxL2 RP 5tGTGTTGTCCCGCCTCCCTTG31 (SEQ ID NO:2)
EGFP FP 5'CTGAGCAAAGACCCCAACGAS' (SEQ ID NO:3) EGFP RP 5'TCGTCCATGCCGAGAGTGA31 (SEQ ID NO:4)
Reactions were performed in 25 uL volumes, in the following conditions: Stage 1: 50C; 2 mins (1 cycle); Stage 2: 95C; 10 mins (1 cycle); Stage 3: 95C; 15 sees; 6OC; 1 min (40 cycles). Reactions contained 5 uL genomic DNA, diluted 1:10 in 10 mM Tris (pH 7.6): 1 mM EDTA, 0.15 uM forward and reverse primers, Ix SYBR Green PCR Mastermix (Applied Biosystems). Volumes were adjusted to 25 uL with MiIIiQ water. For each primer pair, a "no template" control reaction was included, as a test of primer specificity and to ensure the water was not contaminated with gDNA. QPCR reactions were undertaken in 96-well plates, in an ABI Prism Detection System 7000 plate reader. Analyses were performed using ABI Prism SDS software (Applied Biosystems).
Non-denaturing polyacrylamide gel electrophoresis QPCR amplicons were electrophoresed through a 12% non-denaturing polyacrylamide gel, prepared according to Sambrook et al. Molecular Cloning: A Laboratory Manual 2nd Ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989).
Teratoma assay
FACS-sorted pOS (GFP negative) and GFP-bright cells were each resuspended in sterile PBS at a concentration of 106 cells/mL. 0.1 mL (105 ) pOS cells was injected subcutaneously at the right shoulder and hip of 3 male NOD/SCID mie (5 wks of age), The same mice were injected at the contralateral sites with 0.1 mL PBS. A second group of 3 NOD/SCID males (5 wks of age) was injected s.c. at the right shoulder and hip with 0.1 mL (3 x 103) GFP-bright cells, and with 0.1 mL PBS at the contralateral sites. Mice were maintained for 4 months, then euthanased prior to full histopathological analysis by an independent veterinary pathologist (Institute for Medical and Veterinary Science, Adelaide, S.A.).
Histology of embryos
Pregnant females (12.5-16.5 dpc) were euthanased by cervical dislocation. Foetuses were resected and placed in pre-chilled petri dishes containing sterile PBS, maintained on ice. Foetuses were euthanased by hypothermia. Foetuses were transferred to a dissecting microscope, to remove extra-embryonic structures. A small piece of tissue (e.g. tail or hindlimb) was removed from each foetus for DNA extraction and determination of genotype. Whole foetuses were fixed in Bouin's solution (Sigma- Aldrich) and incubated on a rocking platform at room temperature for 24 hrs. Surplus fixative was decanted and diluted by washing foetuses in several changes of 70% (v/v) ethanol over a period of 2-3 days. Foetuses were processed overnight (Leica tissue processor), and embedded in Paraplast Extra embedding wax (Lomb Scientific). 7-10 um thickness saggital sections (Jung Biocut 2035 microtome (Leica)) were dried onto Menzel-Glaser Superfrost™ Plus glass microscope slides (Lomb Scientific) and dried at room temperature.
Immunofluorescent detection of EGFP Sections were immersed in two changes of xylene (20 mins each; room temp.), then rehydrated through an ethanol series (100%, 100%, 95%, 80%, 70%, 50%, 30%), and finally, through two changes of MiIIiQ water. Sections were immersed in each solution for 3 mins and then in antigen unmasking solution (Vector Laboratories H-3300), prepared according to the manufacturer's instruction and brought to boiling point immediately before slides were boiled for a further 5 mins in a microwave. Slides were cooled to room temperature in the antigen retrieval solution, submerged in MiIIiQ water (10 mins; room temp.), then PBTX (PBS containing 0.1% (v/v) Triton X-100), (10 mins; room temp.). Surplus PBTX was drained from the slides before they were overlaid with blocking solution (PBTX containing 10% (v/v) heat-inactivated horse serum), sealed within a humidified chamber, and incubated overnight at 4C. Excess blocking solution was drained from the slides before they were overlaid with either fresh blocking solution, or, with the primary rabbit anti-EGFP polyclonal antibody (Invitrogen A6455), diluted 1 :200 in blocking solution. Slides were sealed within a humidified chamber and incubated overnight at 4C. Slides were drained, immersed in PBTX, blocked for 30 mins at room temp., then overlaid with an Alexa 488-goat anti-rabbit IgGH+L secondary antibody (Invitrogen Al 1008), diluted 1:200 in blocking solution. Slides were sealed within a light-resistant humidified chamber and incubated at room temp, for 1 hr. Slides were rinsed with PBTX, and overlaid with DAPI (4'-6'-Diamidino-2- phenylindole dihydrochloride (2.5 ng/mL) (Sigma-Aldrich)), for 5 mins at room temp, in a light-resistant, humidified chamber. Slides were rinsed with PBTX, mounted with 70% (v/v) glycerol: 30% (v/v) PBS, and sealed with coverslips. Slides were stored at 4C in the dark when not in use. Sections were photographed using either an Olympus BX-51 fluorescent microscope with DP Controller and DP Manager imaging software or an Olympus FVlOOO Confocal Microscope system. Figures were compiled in Adobe Photoshop 7.0 and Adobe Illustrator 10.0 (Adobe Systems Incorporated).
RNA isolation and q RT-PCR genotyping
Total RNA was extracted from cells using an SV Total RNA Isolation System (Promega), with manufacturer's instructions. Total RNA was reverse transcribed using a Superscript III First Strand Synthesis System (Invitrogen) with manufacturer's instructions. QRT-PCR amplification of cDNA was performed in 25 uL reaction volumes, using a dissociation temperature of 6OC. Reactions contained 5 uL cDNA (diluted 1:5 in MiIIiQ water), 0.15 uM forward and reverse primers, and IX SYBR Green PCR Mastermix (Applied Biosystems). Volumes were adjusted to 25 uL with MiIIiQ water. For each primer pair, a "no template" control reaction was included, as a test of primer specificity and to ensure the water was not contaminated with cDNA. To guard against amplification of genomic DNA contaminants, forward and reverse primers (Sigma-Aldrich) were designed to span an intron. 18SrRNA 5' GATCC ATTGGAGGGCAAGTCT3' (SEQ ID NO:5) 18S rRNA 3' CCAAGATCCAACTACGAGCTTTTπ1 (SEQ ID NO:6)
Oct-3/4 FP 51 TGCGGAGGGATGGCATACTG3' (SEQ ID NO:7) Oct-3/4 RP 5' GCACAGGGCTCAGAGGAGGTTCS' (SEQ ID NO:8)
Stra8 FP 5' CCTAAGGAAGGCAGTTTACTCCCAGTC3' (SEQ ID NO:9) Stra8 RP 51 GCAGGTTGAAGGATGCTTTGAGCS' (SEQ ID NO: 10)
Mvh FP 5' AAGCAGAGGGTTTTCCAAGC3' (SEQ ID NO: 11) Mvh RP 5' GCCTGATGCTTCTGAATCGS' (SEQ ID NO: 12)
LIFR FP 51 GACTGGTCGCAATCCACTG3' (SEQ ID NO: 13) LIFR RP 51 GTCGGATCATGAGGAGCAACS' (SEQ ID NO: 14)
Sox2 FP 5' AGGGTGGGGAAAGGAGATT3' (SEQ ID NO: 15) Sox2 RP 5' CGTCGCCAGCCTCTTACTT3' (SEQ ID NO: 16)
Ifitm3 (Fragilisl) FP 5' GTCGGTGCCTGACCATGT3' (SEQ ID NO: 17) Ifitm3 (Fragilisl) RP 5 ' C ATCTTCCGATCCCTAGACTTC3 ' (SEQ ID NO: 18)
Nanog FP 5' AGCCTCC AGC AGATGC AA3' (SEQ ID NO: 19) Nanog RP 5' GGTTTTGAAACCAGGTCTTAACC3' (SEQ ID NO:20)
c-Kit FP 5' GGTTGTCCAACTTATTGAGAAGCS' (SEQ ID NO:21) c-KH RP 5' GCAGTTTGCCAAGTTGGAGTS' (SEQ ID NO:22)
Klf4 FP 5' CGGGAAGGGAGAAGACACTS' (SEQ ID NO:23) Klf4 RP 5' GAGTTCCTCACGCCAACG3' (SEQ ID NO:24)
CdM FP 5' CAGAAGGCGCTGTTCCAG3' (SEQ ID NO:25) CdM RP 5' GTTGACGTCATCGTCTGCAT3' (SEQ ID NO:26) Reactions were performed in 25 uL volumes, in the following conditions: Stage 1: 50C; 2 mins (1 cycle); Stage 2: 95C; 10 mins (1 cycle); Stage 3: 95C; 15 sees; 6OC; 1 min (40 cycles). Reactions contained 5 uL cDNA, diluted 1:5 in MiIIiQ water, 0.15 uM forward and reverse primers, Ix SYBR Green PCR Mastermix (Applied Biosystems). Volumes were adjusted to 25 uL with MiIIiQ water. For each primer pair, a "no template" control reaction was included, as a test of primer specificity and to ensure the water was not contaminated with gDNA.
QRT-PCR reactions were undertaken in 96-well plates, in an ABI Prism Detection System 7000 plate reader. Analyses were performed using ABI Prism SDS software (Applied Biosystems).
RNA extraction, labelling and microarrav hybridization
Total RNA was isolated by RNaqueous Micro column (Ambion). Quality was checked with an Agilent 2100 Bioanalyser (RNA Pico chips). 50ng of RNA was biotin labelled using a Illumina® TotalPrep™ Amplification Kits (Ambion, Inc) with a 14 hour in vitro transcription. 750ng of cRNA was hybridized to Illumina Mouse- Ref8 vl.l BeadChip (Illumina, Inc.). Slides were then scanned on an Illumina Beadstation and bead summarization was performed using BeadStudio Version 3.1.7 (Illumina, Inc). After summarization raw data was exported from BeadStudio with no additional processing.
Data normalisation and filtering
The data exported from BeadStudio was imported into R/BioConductor using the readBead function from the BeadExplorer package (http://bioconductor.Org/packages/l.9/bioc/vignettes/BeadExplorer/inst/doc/BeadHel p.pdf). Background adjustment and quantile normalization5 was performed using algorithms within the Affymetrix package
(http://bioconductor.Org/packages/l.8/bioc/vignettes/affy/inst/doc/affy.pdf) (function: bg.adjust and normalize.quantiles). The normalized data was exported out off R/BioConductor using write.beadData function for further analysis in Genespring GX 7.3.1. software (Agilent Technologies). Genes were initially filtered using Illumina® detection p-value of 0.99 and a floor of 100FU. Genes enriched in the pOS (EGFP-negative) state compared to the reference cells were identified using a Welch parametric t-test, p- value cutoff 0.01, multiple testing correction: Benjamini and Hochberg False Discovery Rate. This restriction tested 8,511 genes. Genes were further described as differentially expressed using a volcano plot fold difference of 2 with a P-value < 0.01. Human-mouse translation tables were built for the Loring dataset using Orthology tables at NIH DAVID (http://david.abcc.ncifcrf.gov/).
Immunochemistry
Cultures of pOS cells plated onto gelatin without feeders on glass coverslips, were cultured for two days, then incubated for 30 minutes in HBSS prior to fixation in modified Zamboni's fixative (2% paraformaldehyde and 0.2% picric acid in 0.1 M phosphate buffer, pH 7.2) from 5 to 30 minutes. The adherent cells were stored in PBS azide (PBS containing 0.1% sodium azide) at 40C until immunofluorescence processing.
The specimens were rinsed in PBS triton (0.1 M PBS and 0.1% Triton-X-100 [TX-IOO]) and permeabilised in DMSO (100%) for 10 minutes, then rinsed in PBS triton for 5 min before being blocked with 10% donkey serum (Sigma Chemical Corporation)) in PBS triton. DMSO was omitted for cell-surface immunostaining. The specimens were incubated with primary antibodies diluted in block buffer over night, at room temperature. The primary antibodies used in single and multiple labelling are listed in Table 1. The specimens were incubated for 30 minutes in block buffer before being incubated for 3 hours with the secondary antibodies diluted in block buffer, followed by washing. The secondary antibodies were donkey anti- rabbit, anti-goat or anti-mouse antibodies (Invitrogen) conjugated with Alexa-488 (green), 594 (red), or 647 (far red). The coverslips with adherent cells were mounted on glass slides using Vectashield DAPI (4'6-diamidino-2-phenylindole-2HCl, Vector Labs) mounting media which labels cell nuclei. No cross-reactivity occurred between the primary and secondary antisera combinations. Control experiments showed omission of either primary antisera abolished visible labelling with the appropriate secondary antibody/fluorophore combination. The specimens were imaged on an Axio Imager Zl epi-fluorescence microscope using 1OX and 2OX Plan-Apochromatic objectives and an oil immersion 63X Plan-Apochromatic objective. Images were captured on an Axiocam Mrm camera using Axio Vision software. Figures were compiled in Adobe Photoshop 7.0 and Adobe Illustrator 10.0 (Adobe Systems Incorporated).
Production of pOS cells in vitro Cells obtained as previously described were resuspended in fresh POSE medium and plated at 30% - 40% confluence in ventilated tissue culture-grade flasks, pre-coated with a solution of 0.1% (w/v) gelatin type A (Sigma- Aldrich), and seeded with a confluent monolayer of freshly-thawed, immortalised, iS7/57¥-mSCF220 mouse stromal cells that were mitotically inactivated by incubation in 10 μg Mitomycin C (Sigma- Aldrich M-4287) / mL POSE medium, minus LIF, SCF, FGF2 and FGF9, (3 hrs; 37C; 5% CO2 in humidified air). POSE culture medium is replaced daily. Cells are passaged every 2 - 3 days and seeded into sterile flasks, pre-coated with gelatin and seeded with freshly-thawed, mitotically-inactivated feeders. The cells may be passaged up to 10 times or more without loss of developmental potency.
Cryopreservation of pOS cells pOS cells are harvested by trypsin digestion (3 mins; 37C; 5% CO2 in humidified air). Trypsin is inactivated by the addition of surplus pOS cell enrichment medium. The cell suspension is transferred to polypropylene centrifuge tubes. Cells are pelleted (1,000 x g; 5-8 mins; 4C or room temp). The supernatant is aspirated and discarded. Cells are resuspended in 90% (v/v) FBS; 10% (v/v) cell culture-tested DMSO, dispensed into cryovials. The cryovials are placed on dry ice for 15 mins then stored for 24 hrs at -80C before transfer to LN2 (preferably vapour phase) for long-term storage.
Culturing of thawed pOS cells pOS cells are removed from the LN2 source and placed on dry ice. Cells are then thawed rapidly by immersion of the cryovial in a 37C waterbath. The cell suspension is diluted in surplus pOS cell enrichment medium and centrifuged (1,000 x g; 5-8 mins; 4C or room temp). The supernatant is aspirated and discarded. The cell pellet is resusupended gently in fresh pOS cell enrichment medium then plated into TC-grade plastic, pre-coated with gelatin and containing a confluent monolayer of feeders. EXAMPLE 2 Further characterization of murine pOS cells
Cell culture protocol Cell source
For each experiment five mice were killed with CO2 and olfactory neurosphere cultures were prepared as described previously (Murrell et al., 2005, Dev Dyn 233, 496). The olfactory mucosa was removed from the nasal septum and placed in ice cold Dulbecco's modified Eagle's medium /HAM F12 (DMEM/F12 ; GIBCO- Invitrogen) supplemented with 10% Foetal Bovine Serum (Bovogen, Australia) and 50 U/ml penicillin and 50 μg/ml streptomycin (GIBCO- Invitrogen). After washing twice in Hank's buffered salt solution (HBSS; GIBCO-Invitrogen), the olfactory mucosa was incubated with Dispase II (2.4U/ml; Roche) for 45 minutes. The olfactory epithelium was isolated from lamina propria under the dissection microscope and both tissues were washed separately in HBSS. The lamina propria was further digested with Collagenase I (Sigma- Aldrich) for 10 minutes and gently triturated. The cells were washed with HBSS. In the mean time, the olfactory epithelium was gently triturated to break sheets of tissue into cells and washed with HBSS. The cell pellets resuspended in DMEM/F12 supplement with 10% FBS and 50U/ml Penicillin and 50μg/ml streptomycin and cultured together in a 6-well tissue culture plate (Nunc) in 5% CO2 at 37°C.
Alternatively, expanded neurospheres were cultured as a monolayer from disrupted neurospheres that are in turn, derived from primary olfactory mucosal cells (olfactory epithelium + lamina propria), as described in Murrell et al., 2005, supra. Briefly, cells were passaged using 0.25% trypsin in 0.02% EDTA (GIBCO-Invitrogen) and seeded onto poly-L-lysine (0.85μg/cm2; Sigma) coated 6-well tissue culture plates (Nunc) in DMEM/F12 supplemented with Insulin, Transferrin and Sodium Selenite (ITS; GIBCO- Invitrogen), 50 ng/ml Epidermal Growth Factor (EGF; Chemicon) and 25 ng/ml Fibroblast Growth Factor 2 (FGF2; Chemicon) to generate neurospheres. After 7-8 days, the neurospheres were collected. They were incubated with 1 ml of TrypLE (GIBCO- Invitrogen) for 10 minutes to dissociate the spheres. The cells were washed once in DMEM/F12 and cultured in DMEM/F12 supplemented with ITS, 50ng/ml EGF and 25ng/ml FGF2 for 48 hours before culturing in pOS cell enrichment medium.
pOS cell enrichment medium DMEM containing 4.5 g glucose/L; 20% (v/v) heat-inactivated (56C; 30 mins) foetal bovine serum; 2 mM Glutamax-1 or 2 mM L-glutamine; 1 mM Na pyruvate; 0.1 mM non-essential amino acids; 30 μM adenosine; 30 μM guanosine; 30 μM cytidine; 30 μM uridine; 10 μM thymidine; 50 U penicillin/mL; 50 μg streptomycin/mL; 50 μg gentamicin/mL; 0.1 mM beta-mercaptoethanol.
Mouse pOS cells
Mouse pOS cells were cultured on mitotically-inactivated S1/S14 mSCF220 stromal feeders, in pOS cell enrichment medium supplemented wtih 1 or more of: 1,000 units ESGRO murine LIF/mL; 40 ng recombinant murine Stem Cell Factor/mL; 20 ng recombinant human FGF-2/mL; 25 ng recombinant human FGF9/mL.
Cell manipulation
Medium was aspirated. Primary cells or their expanded neurosphere derivatives, were flooded with a solution of 0.25% trypsin/EDTA in HBSS. Cells are detached by incubation in the trypsin solution (3-5 mins; 37C; 5% CO2 in humidified air). Trypsin is inactivated by the addition of surplus pOS cell enrichment medium. A uniform cell suspension was generated by gentle pipetting. The cells were then seeded into a tissue culture-grade flask / dish / multi-well plate, pre-coated with 0.1% (w/v) gelatin (type A from porcine skin) and containing a confluent monolayer of mitotically-inactivated S1/S14 stromal cells, expressing a truncated, surface membrane-bound form of murine Stem Cell Factor. pOS cells are cultivated on feeders in pOS cell enrichment medium (37C; 5% CO2 in humidified air). Medium is replaced daily. Cells are passaged every 2-3 days at 60-70% confluency and are seeded into new flasks, pre-coated with gelatin and containing new feeders at a dilution of 1:5 - 1:10. pOS cells may be cultivated on gelatin in the absence of feeders for a short period without detectable changes to their phenotype. Depending on the species and strain, the attainment of a stable, homogeneous population of pOS cells occurs as early as three weeks following initiation of culture of primary cells or expanded neurospheres in pOS cell enrichment medium.
Generation of mouse pOS cells
Cells were cultivated on feeders, and in the presence of one or more of: LIF, SCF, FGF-2, FGF9. Mouse pOS cells that are derived from primary cells, exhibited a stable and homogeneous phenotype that is very similar to that shown by murine pOS cells that are derived from expanded neurospheres.
An example of an isolated mouse cell designated B6 Rosa26-EGFP XY pOS was deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121601
CD antigen expression by murine pOS cells
Murine pOS cells were produced as hereinbefore described and analysed for expression of CD antigens, intracellular OCT-3/4 and SCA-I by flow cytometry. CD (cluster of differentiation) antigens are proteins expressed on the cell surface that are antigenic. Mouse pOS cells were plated into a 96-well plate format. Each well was coated with one antibody, reactive against one species-specific CD or other antigen. All antigens tested are shown in Table 6. Table 7 provides a ranking of expression levels according to mean fluorescence intensity. Highest mean expression levels (>18,000 MFI units) were identified for CD13; CD16/32; CD23; CD34; CD28; CD38; CD40; CD45; CD61; CD69; CD95; CDl 17; CD122; CD124; CD201; and CD309.
Demonstration of pluripotency in vivo
GFP-dim or GFP-negative pOS cells from C57BL/6J ROSA26- EGFP/ROSA26-EGFP mice (see Figure. 1), were collected by fluorescence-activated cell sorting (FACS), and injected into wild type C57BL/6J pre-implantation-stage mouse blastocysts. PCR analysis of EFGP expression was performed using one or both of two sets of primers and cycling conditions: Protocol 1 Forward primer 5' CGA CGT AAA CGG CCA CAA GTT CA 3'(SEQ ID NO:27) Reverse primer 5' GCT TTA CTT GTA CAG CTC GTC CAT 3' (SEQ ID NO:28) under the following PCR cycling conditions: 950C 3 mins; 41 cycles of: 950C 15 sees; 650C for 15 sees, 720C for 1 min; followed by one cycle of 720C for 3 mins; followed by one cycle of 250C for 5 mins and pause at 80C. This generated a 661 bp product from the EGFP template.
Protocol 2
Forward primer 5' CCT GAA GTT CAT CTG CAC CA 3' (SEQ ID NO: 29) Reverse primer 5 ' CCG TCC TCC TTG AAG TCG 3 ' (SEQ ID NO: 30) under the following PCR cycling conditions: 950C 10 mins; 41 cycles of: 950C 15 sees; 650C 30 sees; 720C 50 sees; followed by one cycle of 720C 2 mins and pause at 80C. This generated a 273 bp product from the EGFP template.
Injection of 1 pOS cell into one blastocyst was sufficient to generate chimaeric founder (Fo) mice, and to colonise tissues of endo-, meso- and ectodermal origin, plus the germ cells. All transgenic mice (Fo, Fl, F2) were viable, fertile and remained tumour-free, even after 14 months. The pOS cell-derived EGFP transgene was confirmed in tissues of founder (Fo) mice, and in their Fl and F2 offspring, by qPCR and also by PCR (Figure 8) and Southern analysis. These data show conclusively that pOS cell-derived gDNA contributes to all three embryonal germ layers plus sperm and oocytes.
Protein expression by murine pOS cells
Immunophenotypic analysis of pOS cells was performed on GFP negative cells grown at 37C and 5% CO2 in humidified air in pOS enrichment (POSE) medium, treated with trypsin and then fixed in 4% paraformaldehyde for 10 min at room temperature (RT). Approximately 1 x 105 cells were washed twice with HBSS and incubated 30 min at RT in 0.2 ml PBS/ 1% BSA/ 1% NGS (normal goat serum)/ 0.1% Triton-X 100 together with the following antibodies: anti-human/mouse SOX2 Allophycocyanin (APC)-conjugated (IC2018A, R&D), anti-human NESTIN phycoerythrin-conjugated (IC1259P, R&D), rabbit anti-OCT4 (AB3209, Chemicon), rabbit anti-human-NANOG (AB9220, Millipore), rabbit anti-KLF4 (AB4138, Millipore) and anti-MYC (9402, Cell Signalling Technology). All antibodies and their isotype controls were diluted according to the manufacturer's instructions, or were determined empirically. Cells were washed twice in PBS/1%BSA and incubated 30 min RT with goat anti-rabbit Alexa-488 (Al 1078, Invitrogen). After two washes the cells were resuspended in 200 μL of PBS and analysed by flow cytometry (BD FAC S Aria flow cytometer). Isotype-matched controls were run in parallel for all antibodies. Results shown correspond to a representative flow cytometry histogram chosen from the analysis of 3 independent experiments. For each marker the mean fluorescence intensity (MFI) was normalized to the MFI of the corresponding isotype control. The % of positive cells was calculated as the staining observed above the isotype control.
The level of expression of the pluripotentiality markers OCT-3/4 and SOX2, KLF4, c-MYC, NANOG and a neuronal stem cell marker (NESTIN) were analysed in murine ES cells and pOS cells (Figure 9). OCT-3/4 and SOX2 expression were also compared between MEF, mouse ES cells and mouse pOS cells, as summarized in Figure 10. OCT-3/4-positive staining was observed in all cell types but the level of expression was greater in the ES cells (48.6 vs 25.1). In both cases the staining was considered moderate to high. In addition, SOX2 staining was moderate to high in ES cells and was low to moderate in 47% of pOS cells. NESTIN was positive in only 5% of the ESC with very low levels of expression and in 23% of the pOS cells with low to moderate levels of expression. KLF4, c-MYC and NANOG expression was clearly detected. The MFI of each of these proteins was similar in mouse ES cells and mouse pOS cells. This suggests that these factors may be active in the maintenance of pluripotency in pOS cells.
Immunohistochemistry
Expression of SOX2 and OCT-3/4, NANOG, KLF4, MVH, KIT and NESTIN proteins was compared between murine ES cells and pOS cells. Cells were fixed in Zamboni's solution (13.33% (w/v) paraformaldehyde in phosphate-buffered saturated picric acid, (pH 7.3) 5 mins; room temp.), washed in situ with three changes of PBS then permeabilised with PBS containing 0.1% (v/v) Triton X-100. Nucleic acid was visualised with DAPI stain. Antibodies were Alexa-conjugated, except for anti-SOX2, which was an APC conjugate. All antibodies were used at a 1:200 dilution together with a 1 :200 diluted isotype control. Mouse pOS cells expressed low but detectable levels of SOX2 and OCT-3/4, whereas NANOG, KLF4, MVH, KIT and NESTIN proteins were expressed more abundantly. Murine pOS cells were also analysed for CDl 17 and AP-2γ expression Mouse anti- mouse AP-2γ Ab was used at a 1 :200 dilution with a rabbit anti-mouse Alexa 594 secondary Ab at a 1:200 dilution. Rat anti-mouse CDl 17 Ab was used at a 1:50 dilution with a donkey anti-rat Alexa 594 secondary Ab at a 1 :200 dilution. Secondary antibody controls were used at the same dilution. AP-2γ is a transcription factor and downstream target of Prdml. AP-2γ mediates the suppression of somatic differentiation and the reacquisition of pluripotency (Weber, S. et al. Biol Reprod 2009 [PMID: 19776388]). CDl 17 is a regulator of gametogenesis, mast cell development, haematopoiesis and melanogenesis. Loss of function mutations in CDl 17 results in dose-dependent anaemia, hypopigmentation, infertility and survival. Gain of function mutations in CDl 17 are associated with a range of neoplasms, including acute myelogenous leukaemia, gastrointestinal stromal tumours and mastocytomas (Roskoski, 2005, Biochem Biophys Res Commun; 337: 1-13). Both AP-2γ and CDl 17 were expressed abundantly by pOS cells, suggesting a role for these factors in the maintenance of pOS cell pluripotency.
NOD-SCID tumour assay 1-1.5 million pOS cells were injected beneath the capsule of the left testis of immune-deficient NOD-SCID adult mice (n=8), to test whether pOS cells were similar to mouse ES cells in their capacity to form teratoma in this tissue. None of the mice developed a teratoma. Instead, each mouse developed a slow-growing fibrosarcoma that infiltrated the abdominal wall anterior to the left (injected) testis. Within the testis, there was extensive proliferation of the injected pOS cells, which compromised the blood supply. This led to a loss of integrity of the testis cords, and impaired spermatogenesis. Typically, the fibrosarcoma was evident on palpation, 3 months after injection of the pOS cells.
Testis morphology Fixed testis sections (3 um thickness) of left (injected) and right (uninjected) testes, harvested from NOD-SCID male mouse at 3 months after injection of 1-1.5 x 10e6 pOS cells beneath the capsule of the left testis.
Fibrosarcoma
A 3 μm section of fibrosarcoma, resected from left abdominal wall, anterior to left testis. The tumour mass comprised fibrocytes of mesenchymal origin. The morphology of the injected pOS cells was the same as that of the cells making up the bulk of the fibrosarcoma. These observations suggest that the fibrosarcoma originated from the injected pOS cells. The sub-capsular niche failed to elicit teratoma formation from pOS cells. This phenomenon distinguishes pOS cells from ES cells.
EXAMPLE 3
Production and characterization of a human pluripotent olfactory stem "pOS" cell
Cell culture protocol
Cell source Cells were obtained from expanded neurospheres cultured as a monolayer from disrupted neurospheres that are in turn, derived from primary olfactory mucosal cells (olfactory epithelium + lamina propria), as hereinbefore described. It is anticipated that cells may be obtained from expanded primary adult human olfactory mucosal cells (olfactory epithelium + lamina propria).
Human pOS cells
Human cells were cultured on mitotically-inactivated S1/S14 hSCF220 stromal feeders, in pOS cell enrichment medium supplemented with one or more of: 1,000 units glycosylated human LIF/mL; 40 ng recombinant human Stem Cell Factor/mL; 20 ng recombinant human FGF-2/mL; 25 ng recombinant human FGF9/mL; 5 ng recombinant human TGF-β2/mL; 10 ng recombinant human BMP-4/mL.
Table 8 shows all of the growth factor combinations tested that have yielded human pOS cells from expanded neurospheres. The attainment of a stable, homogeneous population of human pOS cells occurs as early as three weeks following initiation of culture expanded neurospheres in pOS cell enrichment medium.
An example of a human pOS cell is shown in Figure 7B. An example of a human pOS cell human XY pOS-17 was deposited at the
European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121602. pOS cells represent a new member of the pluripotent stem cell family with significant potential clinical application. Unlike other pluripotent stem cells, pOS cells do not form teratomas or tumours after transplantation and they could provide a source of autologous or non-autologous human stem cells for therapy. Human olfactory mucosa is safely accessible via biopsy through the external naris and multipotent olfactory neurosphere-derived cells. These may provide a source of human pOS cells.
Illumina Microarray analyses of pOS cell transcriptomes
Microarray analysis of human pOS cell gene expression. Human pOS cell cultures were initiated from expanded human neurospheres in flasks pre-coated with 0.1% (w/v) gelatin and seeded with a confluent monolayer of mitotically-inactivated Sl/S14-hSCF220 feeders. The cells were cultured in POSE medium, either without added growth factors, or supplemented with the six growth factors (LIF, SCF, FGF- 2, FGF9, TGFβ2, as indicated in Table 8.
In Tables 9-12, the following code is used. "XS" refers to expanded neurospheres; "no GF's" refers to an absence of growth factors (Cate did these cultures include feeders?) "6 GF's" refers to culture in the presence of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF-β2.
Table 9 shows a ranked, fold change in expression of genes compared between pOS cells cultured with or without a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF-β2 and expanded neurospheres from which the pOS cells were derived.
Table 10 shows a ranked, fold increase or induction in expression of genes in pOS cells cultured with a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF- β2 compared to expanded neurospheres from which the pOS cells were derived. Table 11 shows fold decrease in expression of genes compared between pOS cells cultured with or without a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF-β2 and expanded neurospheres from which the pOS cells were derived.
Table 12 shows a ranked, fold difference in expression of genes compared between pOS cells cultured with and without a combination of LIF, FGF-2, FGF9, SCF, BMP-4 and TGF-β2.
Analysis of these data using Ingenuity™ software shows that human pOS cells cultured with or without added growth factors, exhibit an increase in expression of transcripts that encode chromatin modifying proteins, including transcriptional repressors, histone proteins, histone modifying enzymes, and the Ubiquitin pathway. This is coordinated with the down regulation of expression of the interferon signalling pathways that are mediated by SRC, STAT5 and IRF1/7. AKT is implicated as a central coordinator of these events.
PluriNet gene expression in human neurospheres
The expressed PluriNet genes in human neurospheres from which a human isolated mammalian cell may be derived are shown in Table 5. These genes were expressed in neurospheres before transfer to the POSE medium, and not because of the POSE medium.
EXAMPLE 4 Production and characterization of a rat pluripotent olfactory stem "pOS" cell
Cell source Cells were obtained from expanded primary adult rat olfactory mucosal cells
(olfactory epithelium + lamina propria), as hereinbefore described. It is anticipated that cells may be obtainable from expanded neurospheres cultured as a monolayer from disrupted neurospheres that are in turn, derived from primary rat olfactory mucosal cells (olfactory epithelium + lamina propria)
pOS cell enrichment medium
DMEM containing 4.5 g glucose/L; 20% (v/v) heat-inactivated (56C; 30 mins) foetal bovine serum; 2 mM Glutamax-1 or 2 mM L-glutamine; 1 mM Na pyruvate; 0.1 mM non-essential amino acids; 30 uM adenosine; 30 uM guanosine; 30 uM cytidine; 30 uM uridine; 10 uM thymidine; 50 U penicillin/mL; 50 ug streptomycin/mL; 50 μg gentamicin/mL; 0.1 mM beta-mercaptoethanol.
Rat pOS cells
Rat pOS cells are cultured on mitotically-inactivated S1/S14 mSCF220 stromal feeders, in pOS cell enrichment medium supplemented with 1 or more of:
1,000 units ESGRO murine or rat LIF/mL; 40 ng recombinant murine or rat Stem
Cell Factor/mL; 20 ng recombinant human FGF-2/mL; 25 ng recombinant human FGF9/mL.
Cell manipulation
Medium was aspirated. Primary cells or their expanded neurosphere derivatives, were flooded with a solution of 0.25% trypsin/EDTA in HBSS. Cells are detached by incubation in the trypsin solution (3-5 mins; 37C; 5% CO2 in humidified air). Trypsin is inactivated by the addition of surplus pOS cell enrichment medium. A uniform cell suspension was generated by gentle pipetting. The cells were then seeded into a tissue culture-grade flask / dish / multi-well plate, pre-coated with 0.1%
(w/v) gelatin (type A from porcine skin) and containing a confluent monolayer of mitotically-inactivated S1/S14 stromal cells, expressing a truncated, surface membrane-bound form of murine Stem Cell Factor. pOS cells are cultivated on feeders in pOS cell enrichment medium (37C; 5%
CO2 in humidified air). Medium is replaced daily. Cells are passaged every 2-3 days at 60-70% confluency and are seeded into new flasks, pre-coated with gelatin and containing new feeders at a dilution of 1:5 - 1:10. pOS cells may be cultivated on gelatin in the absence of feeders for a short period without detectable changes to their phenotype.
The attainment of a stable, homogeneous population of human pOS cells occurs as early as three weeks following initiation of culture of primary cells or expanded neurospheres in pOS cell enrichment medium. An example of a rat pOS cell is shown in Figure 7C. An example of a isolated rat cell designated SD Rat XY pOS was deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121603.
Throughout the specification the aim has been to describe the preferred embodiments of the invention without limiting the invention to any one embodiment or specific collection of features. It will therefore be appreciated by those of skill in the art that, in light of the instant disclosure, various modifications and changes can be made in the particular embodiments exemplified without departing from the scope of the present invention. All computer programs, algorithms, patent and scientific literature referred to herein is incorporated herein by reference.
Table 1
Plurinetgenes enriched in pOS cells
2-fold compared to
Reference
Genbank RefSeq SymbolJ
NM 008569 NM 008569.1 Anapd
NM 013470 NM 013470.1 Anxa3
NM 009689 NM 009689.1 Birc5
NM 025788 NM 025788.2 Btbd14b
NM 172301 NM 172301.2 Ccnbi
XM 131801 XM 131801.1 Cda
NM 011991 NM 011991.1 Cops3
XM 128714 XM 128714.3 Ddx11
NM 027148 NM 027148.2 Exoscδ
NM 007999 NM 007999.2 Fen1
XM 130877 XM 130877.3 Gmps
NM 010325 NM 010325.1 Got2
NM 008228 NM 008228.1 Hdad
NM 146165 NM 146165.1 Jtv1
XM 130821 XM 130821.1 Kpna2
NM 010693 NM 010693.1 Lck
NM 026309 NM 026309.1 Lsm3
NM 025349 NM 025349.1 Lsm7
NM 008567 NM 008567.1 Mcm6
NM 008628 NM 008628.1 Msh2
NM 010830 NM 010830.1 Msh6
NM 008652 NM 008652.2 Mybl2
NM 010849 NM 010849.2 Myc
NM 053089 NM 053089.2 Nargi
NM 024193 NM "024193.1 Nol5a
NM 053086 NM 053086.1 NoId
NM 019716 NM~ 019716.1 Orc6l
NM 011045 NM 011045.1 Pcna
NM 011072 NM "011072.2 Pf n1
NM 007905 NM 007905.1 Phd
NM 024250 NM 024250.3 Phf10
NM 016966 NM 016966 Phgdh
NM 026398 NM 026398.2 Pop5
NM 031868 NM 031868.1 Pppica
NM 133948 NM 133948.2 Psipi
XM 132528 XM 132528.3 Rfc3
NM 145480 NM 145480 Rfc4
XM 132348 XM 132348.2 Rfc5
NM 026014 NM 026014.3 Ris2
NM 026653 NM 026653.1 Rpa1 NM 026632 NM 026632.1 Rpa3
NM 011358 NM 011358.1 Sfrs2
NM 025656 NM 025656.1 Sip1
NM 031196 NM 031196.1 SId 9a 1
NM 017407 NM 017407.1 Spagδ
NM 178652 NM 178652.1 Supt3h
NM 011552 NM 011552.1 Tcofi
NM 011605 NM 011605.1 Tmpo
NM 024187 NM 024187 U2af1
Table 2
Plurinet genes detected in pOS cells
Genbank RefSeq SymbolJ
NM_019816 NM_019816.1 Aatf
NM 008569 NM_008569.1 Anapd
NM_009672 NM 009672.2 Anp32a
NM_007585 NM_007585.2 Anxa2
NM_013470 NM_013470.1 Anxa3
NM 009687 NM 009687 Apexi
NM_026195 NM_026195.1 Atic
XM_181344 XM_181344.3 Aurkb
NM_057171 NM_057171.1 Bat3
NM 025392 NM 025392.1 Bccip
NM_009689 NM_009689.1 Bircδ
NM 007550 NM_007550 BIm
NM_025788 NM_025788.2 Btbd14b
NM_009773 NM_009773 Bubib
NM_009811 NM 009811.2 Casp6
NM 146089 NMJ46089.1 Ccdcδ
NMJ 72301 NMJ 72301.2 Ccnbi
NM 007631 NM 007631.1 Ccndi
NM_007633 NM_007633.1 Ccnei
XM 131801 XMJ 31801.1 Cda
NM_009862 NM 009862.1 Cdc45l
NM_009863 NMJD09863.1 Cdc7
NM 013733 NM 013733.2 Chafia
NM_016706 NM_016706.1 Coil
NM_011991 NM 011991.1 Cops3
NM_012002 NM_012002.1 Cops6
NM 007829 NM_007829.1 Daxx
XMJ28714 XMJ28714.3 Ddx11
NM_053272 NM_053272.1 Dhcr24
NM 007858 NM_007858.1 Diapi
NM_023479 NM_023479.1 Elac2
NM 011729 NM 011729 Ercc5
XM_284543 XM_284543.2 Exosc7
NM_027148 NM_027148.2 Exoscδ
NM_007991 NM 007991.2 FbI
NM_007999 NM_007999.2 Fen1
NM 057172 NM_057172.1 Fubpi
NM_139149 NM 139149.1 Fus
NM_007836 NM_007836.1 Gadd45a
NM_026053 NM_026053.1 Gemin6
NM 027189 NM 027189.1 Gemin7
XM_130877 XMJ 30877.3 Gmps
NM 010325 NM_010325.1 Got2
NM_022011 NMJ322011.2 Gtf2h2
NM 008228 NM 008228.1 Hdad NM 008229 NM_008229.1 Hdac2
NM_016660 NM_016660.1 Hmgal
NM_010448 NM_010448.2 Hnφab
NM 025279 NM_025279.1 Hnrpk
NM_013559 NM 013559.1 Hsp105
NM_008301 NM_008301.2 Hspa2
NM_031165 NM_031165.3 Hspaδ
NM_010477 NM_010477.2 Hspdi
NM 008303 NM_008303.2 Hspel
NMJI46165 NM 146165.1 Jtv1
XM_130821 XM_130821.1 Kpna2
NM 008379 NM_008379.2 Kpnbi
NM 010693 NM 010693.1 Lck
NM_026309 NM_026309.1 Lsm3
NM_015816 NM 015816.1 Lsm4
NM_025349 NM_025349.1 Lsm7
NM 027290 NM 027290.1 Mem 10
NM_008564 NM_008564.1 Mcm2
NM 008563 NM_008563.1 Mcm3
NM_008566 NM 008566.1 Mcm5
NM_008567 NM_008567.1 Mcm6
NM 019939 NM 019939.1 Mpp6
NM_018736 NM_018736.2 Mre11a
NM_011885 NM_011885.2 Mrps12
NM 008628 NM_008628.1 Msh2
NM_010830 NM 010830.1 Msh6
NM_013602 NM_013602.2 Mt1
NM_138745 NM 138745 Mthfdi
NM_016776 NM_016776.2 Mybbpia
NM 008652 NM_008652.2 Mybl2
NM_010849 NM_010849.2 Myc
NMJ77619 NM 177619.2 Myst2
NM_053089 NM_053089.2 Nargi
NM 010880 NM_010880.2 NcI
NM_008704 NM 008704.2 Nme1
NM_024193 NM_024193.1 Nol5a
NM_026578 NM_026578.1 NoIaI
NM_053086 NM 053086.1 NoId
NM_008726 NM_008726.2 Nppb
NM_008743 NM_008743.1 Nthl1
NM 008637 NM_008637.1 Nudti
NM_016714 NM 016714.2 Nup50
NM_001014425 NM_001014425.1 Orel I
NM 019716 NM_019716.1 Orc6l
NM_011119 NM 011119.1 Pa2g4
NM_008778 NM_008778.1 Pak3
NM_008783 NM_008783.1 Pbx1
NM 011045 NM_011045.1 Pcna
NM_029231 NM 029231.2 PeIpI
NM 011072 NM_011072.2 Pf n1
NM_007905 NM 007905.1 Phc1
NM 024250 NM_024250.3 Phf10
NM_016966 NM_016966 Phgdh NM_177262 NM_177262.3 Pkn1
NM 011636 NM_011636.1 Plscri
NM_025928 NM 025928.1 Pmf1
NM_011131 NM_011131.2 PoIdI
NM 008894 NM_008894.1 Pold2
NM_015810 NM_015810 Polg2
NM 026398 NM_026398.2 Pop5
NM_028753 NM 028753.1 Pop7
NMJ45610 NMJ45610 Ppan
NM 026352 NM_026352.2 Ppid
NM_031868 NM 031868.1 Ppplca
NM_011170 NM_011170.1 Prnp
NM_133948 NM_133948.2 Psipi
NM 011192 NM 011192.2 Psme3
NM_008972 NM_008972.1 Ptma
NM_011223 NM 011223.1 Pxn
NM_009015 NM_009015.2 Rad54l
NM 011237 NM 011237.1 Rad9
NM_026557 NM_026557.2 Rchyl
NM 058214 NM_058214.1 Recql4
XM_132528 XM 132528.3 Rfc3
NM_145480 NMJ 45480 Rfc4
XM_132348 XMJ 32348.2 Rfc5
NM 026014 NM 026014.3 Ris2
NM_026653 NMJD26653.1 Rpa1
NM 011284 NM_011284.2 Rpa2
NM_026632 NM_026632.1 Rpa3
NM 009085 NM_009085.1 Rpo1-1
NM_009087 NM 009087.1 Rpo1-3
NM_009087 NM_009087.1 Rpo1-3
NM_019685 NM_019685.1 RuvbH
NM 173374 NMJ 73374.2 Sfrsi
NM_011358 NM 011358.1 Sfrs2
NM_013663 NM_013663.3 Sfrs3
NM 025656 NM_025656.1 Sip1
NM_019812 NM 019812.1 Sirti
NM_031196 NM_031196.1 Slc19a1
XM 132597 XMJ 32597.3 Smarcadi
NM_009211 NMJ009211.1 Smarcd
NM 011420 NM_011420.1 Smn1
NM_015782 NM_015782.2 Snrpa
NM_009225 NM_009225.1 Snrpb
NM_009226 NM_009226.2 Snrpdi
Snrpf
NM 009896 NMJ309896.1 Socsi
NM_017407 NM 017407.1 Spag5
NM 021448 NM_021448.1 Statipi
NMJ 52220 NMJ 52220.1 Stx3
NM_011503 NMJ011503.2 Stxbp2
NM_009460 NMJD09460.1 Sumol
NM 178652 NMJ 78652.1 Supt3h
NM_019666 NM_019666.1 Syncrip
NM 009319 NM_009319 Tarbp2 NM 011552 NM_011552.1 Tcofl
NM_011605 NM 011605.1 Tmpo
NM_028109 NM_028109.2 Tpx2
NM 011588 NM_011588.1 Trim28
XMJ 27444 XM_127444.3 Trip13
NM_011640 NM_011640.1 Trp53
NM_009446 NM_009446.1 Tuba3
NM_024187 NM_024187 U2af1
NM 011676 NM_011676.2 Unci 19
NM_016794 NM_016794.2 Vamp8
NM_021499 NM_021499.1 Wdr8
XMJ28102 XM 128102.2 Wdyhvi
NM 020570 NM 020570.2 Xrcc2
NM_177643 NM_177643.2 Zfp281
NM 024215 NM 024215.1 Zpf593
Table 3
Plurinet_orthology list median normalised \ )OS cells Rosa Mus
Hand edited on Tue Nov 04 15:21:21 EST 2008
Genes present in [pluri_2] or [Plurinet] pOS cells
Raw fluorescence Genbank SymbolJ
99.05 NM_020567 Gmnn
95.54 NM_007415 Adprti
86.11 NM 001025378 Orc2l
85.65 NM_010068 Dnmt3b
82.52 NM_011237 Rad9
80.64 NM 011677 Ung
77.45 NM_010829 Msh3
72.34 NM_009406 Tnni3
70.94 NM_013672 Sp1
70.50 XM 358372 Ctbp2
62.10 NM_009828 Ccna2
59.30 NM 007523 Bak1
58.45 NM_175400 Sephsi
56.42 NM_211138 Pcytib
53.18 NM_007691 Cheki
52.77 NM_009387 Tk1
48.63 NM_146203 Zpf764
48.36 NM 013545 Hcph
45.41 NMJ72612 Rnd1
38.48 NM 080850 Pask
36.40 NM 011237 Rad9
35.78 NM_177309 4933421 E11Rik
35.37 NMJI33188 Dazapi
34.89 NM 016681 Chek2
34.39 NM_021451 Pmaipi
33.69 NM_010049 Dhfr
33.15 NM 019869 Rbm14
32.31 NM_019689 Arid3b
32.16 NM_133250 Mutyh
31.71 NM 145938 Rpp40
30.44 NM_031181 SiglecM
30.15 NM_030152 Nol3
29.25 NM_009696 Apoe
29.01 NM_011237 Rad9
28.76 NM_009882 Cebpz
27.23 NM_181730 Rpo1-3
27.10 NM 009499 Vasp
24.01 NM_008565 Mcm4
23.58 NM_011634 Traip
22.51 NM_144848 Eppki
22.34 NM 009227 Snrpe
21.46 NM_013902 Fkbp3
21.15 NM 019551 Ttrap
20.65 NM 009860 Cdc25c 19.95 NM_011151 Ppmib
19.44 NM 011968 Psma6
16.96 NM_177309 4933421 E11Rik
16.91 NM_025513 Exosc3
16.85 NM 013633 Pou5f1 Oct3/4
16.58 NM_008110 Gdf9
15.48 NM 008722 Npm1
14.53 NM_007659 Cdc2a
14.48 NM_007546 Biklk
12.80 XM 132755 Nanog
12.62 NM_018789 Mllt7
12.18 NM_009261 Strbp
12.09 NM 009516 Wee1
11.81 NM_033174 Snurf
9.77 NM 010908 Nfkbib
9.49 NM_009556 Zfp42
9.20 NM 015817 Ppap2c
9.14 NM_025415 Cks2
9.02 NM_019512 Tcergi
8.86 NM 009741 Bcl2
8.60 NM_015733 Casp9
8.44 NM 019733 Rbpms
8.07 NM_009401 Tnfrsfδ
8.04 NM_009988 Cxadr
7.82 NMJ 75303 SaIM
7.69 NMJ 73762 Cenpe
7.58 NM_019393 Exosc9
7.09 NM 178616 Psmd11
7.00 NM_008034 FoIrI
6.92 NM 013632 Pnp
6.84 XMJ 25954 Erbb3
6.71 NM 011184 Psma3
6.70 NMJD13773 Tcl1b1
6.65 NM 010346 Grb7
6.33 NM_008891 Pnn
6.28 NM_010848 Myb
6.22 NM 009606 Actal
6.19 XM_358869 Dppa2
6.09 NM_013670 Snrpn
5.95 NMJ023871 Set
5.88 NM_010773 Mbd2
5.74 NM 008831 Phb
5.70 NM_007858 Diapi
5.57 NM_025520 Lsm5
5.47 NM 024285 Bves
5.42 NM_010439 Hmgbi
5.32 NM_010768 Matk
5.04 NMJ 75749 Nup153
4.99 NM 029977 PoIq
4.96 NM_021099 Kit
4.91 NM 007630 Ccnb2
4.90 NMJ311504 Stxbp3
4.63 NM 016859 Bvsl 4.62 NMJ309874 Cdk7
4.45 NMJ44841 Otx2
4.44 NM 010849 Myc
4.44 NM_009533 Xrccδ
4.41 NM_011562 Tdgfi
4.35 NM_015765 Hspa14
4.19 NM_012012 Exo1
4.13 NM 011721 Wrn
4.11 NM 013552 Hmmr
4.04 NM 009278 Ssb
Table 4
Plurinet_ortholog> ' list median normalised pOS cells Rosa Mus
Hand edited on Tue Nov 04 15:21:21 EST 2008
Genes present in [pluri_2] or [Plurinet] pOS cells
Raw fluorescence Genbank Symbol I
29811.32 NM 013602 Mt1
27477.97 NMJ307585 Anxa2
24153.31 NM_031165 Hspaδ
18331.27 NM_010448 Hnrpab
16224.09 NM_008704 Nme1
13468.14 NM_016660 Hmgai
10018.97 NM_009226 Snrpdi
9426.97 NM 013470 Anxa3
8829.10 NM_011072 Pf n1
7622.83 NM_031868 Pppica
7592.03 NM_011991 Cops3
7257.88 NM_026653 Rpa1
7014.66 NM_008972 Ptma
6694.12 NM 025349 Lsm7
6551.64 NM_003095 Snrpf
6369.04 NM_173374 Sfrs1
5751.13 NM_008566 Mcm5
5555.94 NM_026352 Ppid
5361.51 NM_019716 Orc6l
4772.94 NM 012002 Cops6
4352.20 NM_011588 Trim28
4023.31 NM 007991 FbI
4000.61 NM_007999 Fen1
3572.81 NM_009087 Rpo1-3
3358.59 NM 026578 NoIaI
3103.30 NM_011170 Prnp
3095.99 XM_284543 Exosc7
2791.05 NM_010830 Msh6
2650.19 NM_008564 Mcm2
2617.83 NM_009087 Rpo1-3
2433.70 NM_011640 Trp53
2270.74 NM_007631 Ccndi
2201.13 NM_013559 Hsp105
2186.59 NM_024193 Nol5a
2126.41 NM_024250 Phf10
2097.10 NM_008894 Pold2
2050.14 NM 026014 Ris2
2029.67 NM_024187 U2af1
2009.90 NM_172301 Ccnbi
1993.73 XM_130821 Kpna2
1985.69 NM_009225 Snrpb
1977.14 NM_026632 Rpa3
1957.23 NM_021448 Statipi 1901.50 NM_008228 Hdad
1898.49 NM_008567 Mcm6
1756.42 NM 146165 Jtv1
1745.35 NM_022011 Gtf2h2
1738.24 NM_026398 Pop5
1734.67 NM 008303 Hspel
1641.33 NM_015816 Lsm4
1608.78 NM 011420 Smn1
1606.76 NM_009863 Cdc7
1600.43 NM_009687 Apexi
1576.08 NM 011192 Psme3
1520.74 NM_011119 Pa2g4
1482.60 NM_178652 Supt3h
1477.52 NM 007905 Phd
1473.17 NM_009689 Birc5
1467.90 NM 008229 Hdac2
1382.04 XMJ81344 Aurkb
1363.66 NM 017407 Spag5
1285.07 NM 011885 Mrps12
1246.03 NM_026309 Lsm3
1222.51 NM 008569 Anapd
1210.59 NM_139149 Fus
1201.31 NM_009015 Rad54l
1192.71 NM 010477 Hspdi
1190.14 NM_008379 Kpnbi
1151.51 XM 132348 Rfc5
1108.94 NM 015782 Snrpa
1101.00 NM_011552 Tcofi
1024.67 NM 011131 PoIdI
1023.60 NMJD27148 Exoscβ
1020.94 NM_019816 Aatf
1010.47 NM 011284 Rpa2
1006.28 NM_008301 Hspa2
996.12 NM_016794 Vampδ
962.63 NM 011636 Plscri
945.55 XM 128714 Ddx11
941.83 NM_057171 Bat3
919.60 NM 019685 RυvbH
866.90 NM_009773 Bubib
815.01 NM 009085 Rpo1-1
803.10 NM_011503 Stxbp2
803.01 NM_145610 Ppan
781.07 NM_013733 Chafia
779.94 NM_133948 Psipi
776.72 NM 009811 Casp6
772.82 NM_008778 Pak3
740.43 NM_007550 BIm
736.75 NM_011045 Pcna
728.94 NM 026053 Gemin6
691.73 NM_138745 Mthfdi
663.02 NM 010325 Got2
631.26 NM_026195 Atic
598.45 NM 031196 SId 9a1 587.05 NM_009672 Anp32a
566.58 NM 146089 Ccdc5
554.79 XM 132528 Rfc3
542.08 NM_007633 Ccnei
536.25 NM_013663 Sfrs3
530.06 XM 131801 Cda
524.49 NM_016966 Phgdh
520.38 NM_021499 Wdr8
505.62 NM_026557 Rchyl
483.21 NM_025279 Hnrpk
471.06 NM 058214 Recql4
461.21 NM_152220 Stx3
457.60 XM_130877 Gmps
454.00 NM 008743 NthM
447.49 NM_057172 Fubpi
446.36 NM_010880 NcI
438.57 NM_025928 Pmf1
425.69 NM 053089 Nargi
421.40 NM_008563 Mcm3
416.25 XM_132597 Smarcadi
401.23 NM_007829 Daxx
386.03 NMJ77619 Myst2
385.98 NM_011605 Tmpo
383.80 NM 027290 Mem 10
382.31 NM_007836 Gadd45a
375.83 NM 029231 PeIpI
361.17 NM_028753 Pop7
338.41 NM 016714 Nup50
315.28 NM_008783 Pbx1
298.22 NM_025392 Bccip
277.04 NM_011237 Rad9
262.70 NM 019939 Mpp6
254.26 NM_009460 Sumol
252.15 NM_025788 Btbd14b
250.56 XM 128102 Wdyhvi
242.98 NM_010693 Lck
242.81 NM_008637 Nudti
234.69 NM 001014425 Orel I
233.99 NM_177643 Zfp281
230.51 NM_009862 Cdc45l
227.98 NM_008628 Msh2
226.60 NM 177262 Pkn1
224.27 NM_023479 Elac2
219.76 NM_019666 Syncrip
215.06 NM 009446 Tuba3
214.19 NM_053086 NoId
210.39 NM_019812 Sirti
201.09 NM_009896 Socsi
200.60 NM 015810 Polg2
200.14 NM_007858 Diapi
191.39 NM 025656 Sip1
185.13 NM_011729 Ercc5
176.18 NM 145480 Rfc4 153.43 NM 018736 Mre11a
149.41 NM_027189 Gemin7
147.74 NM_010849 Myc
147.22 NM 008652 Mybl2
146.06 NM_020570 Xrcc2
145.15 NM_009319 Tarbp2
140.04 NM_008726 Nppb
139.50 NM_024215 Zpf593
138.25 NM 011676 Unci 19
133.36 NM_053272 Dhcr24
124.42 NM_016706 Coil
110.33 NM 028109 Tpx2
110.12 XM_127444 Trip13
106.53 NM_011358 Sfrs2
103.29 NM_009211 Smarcd
103.20 NM 011223 Pxn
101.97 NM_016776 Mybbpia
99.05 NM_020567 Gmnn
95.54 NM 007415 Adprti
86.11 NM_001025378 Orc2l
85.65 NM 010068 Dnmt3b
82.52 NM 011237 Rad9
80.64 NM_011677 Ung
77.45 NM_010829 Msh3
72.34 NM 009406 Tnni3
70.94 NM_013672 Sp1
70.50 XM 358372 Ctbp2
62.10 NM_009828 Ccna2
59.30 NM 007523 Bak1
58.45 NM_175400 Sephsi
56.42 NM_211138 Pcytib
53.18 NM_007691 Cheki
52.77 NM 009387 Tk1
48.63 NMJ46203 Zpf764
48.36 NM_013545 Hcph
45.41 NM 172612 Rnd1
38.48 NM_080850 Pask
36.40 NM_011237 Rad9
35.78 NM_177309 4933421 E11Rik
35.37 NM 133188 Dazapi
34.89 NM 016681 Chek2
34.39 NM_021451 Pmaipi
33.69 NM 010049 Dhfr
33.15 NM_019869 Rbm14
32.31 NM_019689 Arid3b
32.16 NM 133250 Mutyh
31.71 NM_145938 Rpp40
30.44 NM_031181 Siglecli
30.15 NM_030152 Nol3
29.25 NM_009696 Apoe
29.01 NM 011237 Rad9
28.76 NM_009882 Cebpz
27.23 NMJ81730 Rpo1-3 27.10 NM 009499 Vasp
24.01 NM_008565 Mcm4
23.58 NM_011634 Traip
22.51 NM 144848 Eppki
22.34 NM_009227 Snrpe
21.46 NM_013902 Fkbp3
21.15 NM_019551 Ttrap
20.65 NM_009860 Cdc25c
19.95 NM 011151 Ppmib
19.44 NM_011968 Psma6
16.96 NM_177309 4933421 E11Rik
16.91 NM 025513 Exosc3
16.85 NM_013633 Pou5f1 Oct3/4
16.58 NM_008110 Gdf9
15.48 NM_008722 Npm1
14.53 NM 007659 Cdc2a
14.48 NM_007546 Biklk
12.80 XM_132755 Nanog
12.62 NM 018789 Mllt7
12.18 NM_009261 Strbp
12.09 NM 009516 Wee1
11.81 NM_033174 Snurf
9.77 NM_010908 Nfkbib
9.49 NM 009556 Zfp42
9.20 NM 015817 Ppap2c
9.14 NM_025415 Cks2
9.02 NM 019512 Tcergi
8.86 NM_009741 Bcl2
8.60 NM 015733 Casp9
8.44 NM_019733 Rbpms
8.07 NM_009401 Tnfrsfβ
8.04 NM_009988 Cxadr
7.82 NM 175303 SaIW
7.69 NM_173762 Cenpe
7.58 NM_019393 Exosc9
7.09 NMJ78616 Psmd11
7.00 NM_008034 FoIrI
6.92 NM 013632 Pnp
6.84 XM_125954 Erbb3
6.71 NM 011184 Psma3
6.70 NM_013773 TcH b1
6.65 NM_010346 Grb7
6.33 NM 008891 Pnn
6.28 NM_010848 Myb
6.22 NM_009606 Actal
6.19 XM 358869 Dppa2
6.09 NM_013670 Snrpn
5.95 NM_023871 Set
5.88 NM_010773 Mbd2
5.74 NM_008831 Phb
5.70 NM 007858 Diapi
5.57 NM_025520 Lsm5
5.47 NM 024285 Bves 5.42 NM_010439 Hmgbi
5.32 NM 010768 Matk
5.04 NMJ 75749 Nup153
4.99 NM_029977 PoIq
4.96 NM 021099 Kit
4.91 NM_007630 Ccnb2
4.90 NM_011504 Stxbp3
4.63 NM_016859 Bysl
4.62 NM_009874 Cdk7
4.45 NM 144841 Otx2
4.44 NM_010849 Myc
4.44 NM_009533 Xrcc5
4.41 NM_011562 Tdgfi
4.35 NM_015765 Hspa14
4.19 NM_012012 Exo1
4.13 NM_011721 Wrn
4.11 NM 013552 Hmmr
4.04 NM 009278 Ssb
Table 5
List of genes detected in pOS cells and in neurosphere-derived cells generated from human olfactory mucosa (equivalent to the Reference cells in the pOS transcriptome analysis)
These are genes shared by pOS cells and human neurosphere-derived cells that are also present in the PluriNet, the network of 300 genes common to a set of human pluripotent cell types - ES, iPS, EC.
Reference: F. J. Muller, L. C. Laurent, D. Kostka et al., Nature 455 (7211 ), 401 (2008).
Gene Common Names Synonyms Genbank
16E1BP 16E1BP NM_004237
A1; RFC37; MGC27291 A1; RFC37; MGC27291 NMJ81573
ABBP1; FLJ40338 ABBP1; FLJ40338 NM_031266
ABBP1; FLJ40338 ABBP1; FLJ40338 NM_004499
ANX3 ANX3 NM_005139
APC 1; MCPR; TSG24 TSG24; MCPR; APC 1 NM_022662
APE; APX; APE1; APEN; APEX; APEX; REF1; APE1; HAP1; HAP1; REF1; REF-1 APE; APX; REF-1; APEN NM_080649
ASF; SF2; SF2p33; SRp30a; SF2; SF2p33; MGC5228; MGC5228 ASF; SRp30a NM_001078166
MRE11 B; MRE11; ATLD;
ATLD; HNGS1; MRE11; MRE11B HNGS1 NM_005591 AWD; GAAD; NM23; NDPKA; NDPKA; NM23-H1; NM23; NM23-H1 AWD; GAAD NM_000269
AWD; GAAD; NM23; NDPKA; NDPKA; NM23-H1 ; NM23; NM23-H1 AWD; GAAD NMJ 98175
PRAD1; D11S287E; BCL1;
BCL1; PRAD1; U21B31 ; D11S287E U21B31 NM 053056
MGC10606; CCNL1 ;
BM28; CCNL1 ; CDCL1; cdc19; MITOTIN; CDCL1; D3S3194; MITOTIN; KIAA0030; KIAA0030; D3S3194; BM28; MGC 10606 cdc19 NM_004526 CDC2; POLD CDC2; POLD NM_002691
MGC5315; CDC46; P1-
CDC46; MGC5315; P1-CDC46 CDC46 NM 006739
CJD; GSS; PrP; ASCR; PRIP; PrPc; CD230; PrP33-35C; ASCR;
CD230; MGC26679; PrP27-30; PrP27-30; GSS; CJD; PRIP;
PrP33-35C PrPc; PrP; MGC26679 NM_001080121
CLN80; p80-coilin p80-coilin; CLN80 NM_004645 c-Myc c-Myc NM_002467
PRO2249; CNA43;
CNA43; PRO2249; MGC 126776 MGC126776 NM_018518 COD; SNRPB1; snRNP-B; snRNP-B; SNRPB1 ; COD; SmB/SmB1 SmB/SmB1 NM_003091
COD; SNRPB1; snRNP-B; snRNP-B; SNRPB1 ; COD;
SmB/SmB1 SmB/SmB1 NM_003091
CPN10; GROES; HSP10 CPN10; GROES; HSP10 NM_002157
CPN60; GROEL; HSP60; HSP65; HuCHA60; GROEL; HSP60;
SPG13; HuCHAβO SPG13; CPN60; HSP65 NM_002156
CPN60; GROEL; HSP60; HSP65; HuCHA60; GROEL; HSP60;
SPG13; HuCHA60 SPG13; CPN60; HSP65 NM 002156 CSBP; TUNP; FLJ41122;
CSBP; TUNP; HNRNPK; FLJ41122 HNRNPK NM_031263
CSN6; MOV34-34KD MOV34-34KD; CSN6 NM_006833
CYPD; CYP-40; MGC33096 MGC33096; CYPD; CYP-40 NM_005038
DAP6; BING2; MGC126245; MGC126246; BING2;
MGC126246 MGC126245; DAP6 NM_001350
DBK; PKN; PAK1; PRK1; PRKCL1; PRKCL1; PAK1 ; PKN; DBK;
MGC46204 PRK1; MGC46204 NM. _213560
DDIT1 ; GADD45 GADD45; DDIT1 NM 001924
DED; CHE1; CHE-1 CHE1; CHE-1; DED NM. _012138
GD:C20orf1; HCTP4;
DIL2; p100; DIL-2; HCTP4; FLS353; C20orf1; FLS353; DIL-2;
HCA519; REPP86; C20orf1; HCA519; DIL2; p100;
C20orf2; GD:C20orf1 REPP86; C20orf2 NM. _012112
DRF1; DFNA1 ; LFHL1; hDIA1; LFHL1; hDIA1; DFNA1 ;
FLJ25265 FLJ25265; DRF1 NM 005219
DUP; RIS2 DUP; RIS2 NM. .030928
EBP1 ; HG4-1; p38-2G4 p38-2G4; HG4-1 ; EBP1 NM. _006191
EDB; VAMP5 VAMP5; EDB NM 003761
EDR1 ; HPH1; RAE28 HPH1; EDR1; RAE28 NM. .004426
ELC2; HPC2; FLJ10530; FLJ36693; ELC2; FLJ10530; FLJ36693;
FLJ42848 HPC2; FLJ42848 NM. .018127
FBP; FUBP FBP; FUBP NM 003902
FIB; FLRN; RNU3IP1 RNU3IP1; FLRN; FIB NM. .001436
FLJ 16691 FLJ 16691 NM 002859
FLJ20430; MGC99569 FLJ20430; MGC99569 NM. .017818
FLJ23459 FLJ23459 NM 024775
FLJ40994 FLJ40994 NM. .002080
G3; D6S52E BAG-6; G3; D6S52E; BAG6 NM. .080702
Ga19; NAT1 ; NATH;
Ga19; NATH; TBDN 100 TBDN 100 NM 057175
GAR1 GAR1 NM. .018983
GAR1 GAR1 NM _032993
GEMIN2; SIP1 -delta GEMIN2; SIP1-delta NM. .001009182
GTBP; HSAP; HNPCC5 HSAP; GTBP; HNPCC5 NM_ .000179
H2-ALPHA NM_ .207312
HCC5; P1.h; RLFB; MGC1157; P1- RLFB; HCC5; P1-MCM3;
MCM3 MGC1157; P1.h NM_ .002388
HD1 ; RPD3; GON-10; RPD3L1; GON-10; DKFZp686H 12203;
DKFZp686H 12203 HD1; RPD3; RPD3L1 NM_ .004964
HEI-C; HsT1461; FLJ21094; FLJ40084; HEI-C; FLJ21094;
FLJ40084 HsT1461 NM_ .138443
HERMES HERMES NM .006867
HERMES HERMES NM_ .001008710
HMX3; MNAR; P160 P160; HMX3; MNAR NM_ .014389
HP55; POLB; PEOA4; POLGB; POLB; POLGB; HP55;
MTPOLB MTPOLB; PEOA4 NM 007215
HRG4 HRG4 NM_ .054035
HRI; KIAA1369 KIAA1369; HRI NM_ .014413
Hsk1; CDC7L1; HsCDC7; huCDC7; MGC126237; CDC7L1; MGC 117361 ; MGC 126237; huCDC7; MGC126238;
MGC 126238 HsCDC7; Hsk1; MGC117361 NM 003503 HSP105B;
HSP105; HSP105A; HSP105B; DKFZp686M05240; HSP105; KIAA0201; NY-CO-25; HSP105A; NY-CO-25;
DKFZp686M05240 KIAA0201 NM_006644
RPA70; REPA1; RF-A;
HSSB; RF-A; RP-A; REPA1; RPA70 HSSB; RP-A NM_002945
IPOB; NTF97; MGC2157;
IMB1; IPOB; Impnb; NTF97; Impnb; MGC2155; IMB1;
MGC2155; MGC2156; MGC2157 MGC2156 NM_002265
JAB; CIS1; SSH ; TIP3; CISM; SSI- SSI-1 ; CISH1; SSH; CIS1;
1; SOCS-1 JAB; TIP3; SOCS-1 NM_003745
JTV1; P38; AIMP2; PRO0992 AIMP2; PRO0992; P38 NM_006303
KAP1 ; TF1B; RNF96; TIF1B; FLJ29029; TIF1B; RNF96;
FLJ29029 TF1B; KAP1 NM_005762
Ki; PA28G; REG-GAMMA; PA28- PA28-gamma; PA28G; Ki; gamma REG-GAMMA NM_005789
KIAA0018; SELADIN 1; NblaO3646; NblaO3646; seladin-1; seladin-1 SELADIN 1 ; KIAA0018 NM_014762
C15orf1; PP32; PHAPI;
LANP; MAPM; PP32; PHAP1; MGC150373; PHAP1; PHAPI; I1PP2A; C15orf1 ; I1PP2A; LANP; MAPM; MGC119787; MGC150373 MGC119787 NM_006305
MGC131511 ; HSC54;
LAP1; HSC54; HSC70; HSC71; HSPA10; MGC29929; HSP71; HSP73; NIP71; HSPA10; HSC70; HSP71; HSP73; MGC29929; MGC131511 LAP1; HSC71; NIP71 NM_153201
MGC131511; HSC54;
LAP1; HSC54; HSC70; HSC71 ; HSPA10; MGC29929; HSP71; HSP73; NIP71; HSPA10; HSC70; HSP71; HSP73; MGC29929; MGC131511 LAP1; HSC71; NIP71 NM_006597 hMAP126; DEEPEST;
MAPI 26; DEEPEST; hMAP126 MAPI 26 NM_006461
MCH2 MCH2 NM_001226
MF1; RAD2; FEN-1 RAD2; FEN-1 ; MF1 NM_004111
DKFZp686B09108;
MGC126627; DKFZp686B09108 MGC126627 NM_002585
MGC8367 MGC8367 NM_182649
MMTRA1B MMTRA1B NM_021105
MTH 1 MTH 1 NM_198950
MTHFC; MTHFD MTHFC; MTHFD NM_005956
NME1-NME2; NME2 NME2 NM_001018136
NOP56 NOP56 NM_006392
NPAP60; MGC39961;
NPAP60; NPAP60L; MGC39961 NPAP60L NM_007172
NTH1; OCTS3 NTH1; OCTS3 NM_002528
ORC6 ORC6 NM_014321
P130; NOPP130; NOPP140; P130; NOPP140; KIAA0035; KIAA0035; NS5ATP13 NOPP130; NS5ATP13 NM_004741 P160; PAP2; FLJ37886 P 160; PAP2; FLJ37886 NM_014520 P36; LPC2D; ANX2L4;
P36; ANX2; LIP2; LPC2; CAL1H; ANX2; PAP-IV; CAL1H; LPC2D; ANX2L4; PAP-IV LIP2; LPC2 NM_001002857 p52; p75; PAIP; DFS70; LEDGF; MGC74712; PAIP; LEDGF; PSIP2; MGC74712 p75; PSIP2; p52; DFS70 NM 033222 p52; p75; PAIP; DFS70; LEDGF; MGC74712; PAIP; LEDGF; PSIP2; MGC74712 p75; PSIP2; p52; DFS70 NM_021144 p53; LFS1; TRP53 TRP53; p53; LFS1 NM 000546 hRrp42p; FLJ26543; Rrp42p; p8; EAP1; RRP42; Rrp42p; KIAA0116; p8; EAP1; hRrp42p; FLJ26543; KIAA0116 RRP42 NM 015004 p9; CIP3; EAP2; OIP2; RRP43; Rrp43p; EAP2; RRP43; Rrp43p; bA421P11.3; RP11- RP11-421 P11.3; CIP3; 421 P11.3 bA421P11.3; OIP2; p9 NM 181503
PGD; 3-PGDH; PGDH; PDG;
PDG; PGD; PGAD; PGDH; SERA; SERA; PGAD; MGC3017;
3PGDH; 3-PGDH; MGC3017 3PGDH NM_006623
PFN 1 NM_005022
PMF1 NM_007221
PP-1A; PPP1A; MGC1674; PP-1A; MGC15877;
MGC15877 MGC1674; PPP1A NM 001008709 dJ3J17.2; pp68; RP1-3J17.2; pp68; NSAP1 ; HNRPQ1; GRY- HNRPQ1; hnRNP-Q; RBP; dJ3J17.2; RP1-3J17.2 NSAP 1; GRY-RBP NM_006372 puf; NDPKB; NM23B; NM23-H2; MGC111212 NME2 NM_001018136
PURH; AICAR; AICARFT; PURH; AICARFT; AICAR;
IMPCHASE IMPCHASE NM_004044
RAD9 RAD9 NM_004584
REPA2; RPA32 REPA2; RPA32 NM_002946
REPA3 REPA3 NM_002947
DKFZp313J1712; U2AFBP;
RN; FP793; U2AF35; U2AFBP; U2AF35; RN; RNU2AF1 ; RNU2AF1; DKFZp313J1712 FP793 NM_001025203
RPA5; RPA39; RPA40; RPAC1; RPAC 1 ; RPA40; RPA5;
RP3-337H4.4 RPA39; RP3-337H4.4 NM_203290
RPA5; RPA39; RPA40; RPAC1; RPAC1; RPA40; RPA5;
RP3-337H4.4 RPA39; RP3-337H4.4 NM_203290
MGC9850; RPAC2; RPA16;
RPA9; RPA16; RPAC2; POLR1C; RPA9; POLR1C; FLJ20616; RPO1-3; MGC9850; FLJ20616 RPO1-3 NM_152705
MGC9850; RPAC2; RPA16;
RPA9; RPA16; RPAC2; POLR1C; RPA9; POLR1C; FLJ20616; RPO1-3; MGC9850; FLJ20616 RPO1-3 NM_015972 RPD3; YAF1 YAF1 ; RPD3 NM_001527
0610037N12Rik; RPP20;
RPP2; RPP20; 0610037N12Rik RPP2 NM_005837
RPP2; RPP20; HSPC004 HSPC004; RPP20; RPP2 NM_198202
RPS12; RPMS12; RPSM12; MPR- MPR-S12; MT-RPS12;
S12; MT-RPS12 RPS12; RPSM12; RPMS12 NM_033362
Rsc8; SRG3; SWI3; BAF 155; BAF155; CRACC1; SWI3;
CRACC1 Rsc8; SRG3 NM_003074
RVB1; ECP54; TIP49; NMP238; ECP54; RVB1; NMP238;
TIP49A TIP49; TIP49A NM_003707
SC35; PR264; SC-35; SFRS2A; PR264; SRp30b; SC35;
SRp30b SFRS2A; SC-35 NM_003016
SGN3 SGN3 NM_003653
SIR2L1 SIR2L1 NM 012238 SMA; SMN; SMA1; SMA2; SMA3; SMNT; SMA2; SMN; SMA3;
SMA4; SMA@; SMNT; BCD541 ; T- SMA@; SMA; BCD541; T-
BCD541 BCD541 ; SMA4; SMA1 NM_000344
SMD1; SNRPD; HsT2456 SNRPD; HsT2456; SMD1 NM_006938
SMN; SM-D; RT-LI; HCERN3;
SNRNP-N; SNURF-SNRPN NM_005678
SNURF-SNRPN; HCERN3;
SMN; SM-D; RT-LI; HCERN3; SMN; RT-LI; SM-D; SNRNP- SNRNP-N; SNURF-SNRPN N NM_022806 SMX4; USS2; YLR438C USS2; YLR438C; SMX4 NM_014463
SNURF-SNRPN; HCERN3; SMN; RT-LI; SM-D; SNRNP-
SNRPN N NM_022806
MGC4980; SELD; SPS;
SPS; SELD; SPS1; MGC4980 SPS1 NM_012247
SPT3; SPT3L SPT3L; SPT3 NM_181356
SPT3; SPT3L SPT3L; SPT3 NMJ81356
SRp20 SRp20 NM_003017
SSF; SSF1; SSF2; BXDC3; MGC14226; SSF2; SSF1 ;
MGC14226; MGC45852 BXDC3; SSF; MGC45852 NM_020230
SSK1; BUBR1; ButrtA; MAD3L; Bub1A; hBUBRI; MAD3L; hBUBR1; BUB1beta BUB1beta; SSK1; BUBR1 NM_001211 SHINC-2; ELP2; StIP;
StIP; SHINC-2; STATIP1; FLJ10879 FLJ10879; STATIP1 NM_018255
STX3A STX3A NM_004177
TOK-1 TOK-1 NM_078468
TOK- 1 TOK-1 NM_016567
TOK-1 TOK-1 NM_016567
TP; LAP2; CMD1T; PRO0868; MGC61508; PRO0868;
MGC61508 CMD1T; TP; LAP2 NM_003276
TRBP; TRBP1; TRBP2 TRBP1; TRBP; TRBP2 NMJ34323
U1A U1A NM_004596 pp10122; UNC18B;
UNC18B; Hunc18b; UNC18-2; MUNC18-2; UNC18-2; pp10122; MUNC18-2 Hundδb NM_006949 VAM1; p55T; PALS2; VAM-1 p55T; PALS2; VAM-1 ; VAM 1 NM_016447 WDR50; CGI-48 WDR50; CGI-48 NM_016001
XAP135; FLJ10975;
XAP135; FLJ10975; MGC111009 MGC111009 NM_018288
XPG; UVDR; XPGC; COFS3; XPG; ERCM2; UVDR;
ERCM2 XPGC; COFS3 NM_000123
YER112W YER112W NM_012321
YNL147W YNL147W NM_016199
ZBP-99; ZNP-99; FLJ 12859; FLJ 12859; ZNP-99; ZBP-99;
FLJ 14378 FLJ14378 NM_012482
ZT86 ZT86 NM 015871 TABLE 6
Protein P1 #Events P1 % Parent P1 PE (575/26) -A Mean P2 #Events P2 VoParent P2 PE (575/26) -A Mean
CD1d 3079 95.5 140 2 0.1 588
Noab 2762 95.5 150 1 0 826
Noab 2021 95.2 30 0 0
CD2 2896 94.8 85 1 0 792
CD3 3030 95 110 14 0.5 11526
CD4 3478 95 108 3 0.1 4152
CD5 3723 95.2 170 17 0.5 608
CD8a 4063 94.5 139 19 0.5 2239
CD11a 3485 95.6 148 18 0.5 6197
CD11b 3869 94.6 152 9 0.2 926
CD11c 3377 94.7 72 7 0.2 7269
CD13 3939 94.8 1752 307 7.8 20839
CD14 3685 95.7 184 28 0.8 6879
CD16/32 3806 95.7 496 53 1.4 26987
CD18 2522 94.5 58 12 0.5 2824
CD19 3612 95.2 119 3 0.1 1602
CD23 3386 94.7 173 21 0.6 21510
CD24 3577 92 6003 3015 84.3 7098
CD25 4367 95.1 256 148 3.4 3078
CD27 4007 95.4 160 33 0.8 2942
CD28 4184 95.1 576 51 1.2 38652
CD29 4292 95.1 738 2942 68.5 927
CD30 3414 93.6 100 80 2.3 828
CD31 4673 94.8 98 10 0.2 1211
CD34 3963 95.4 275 63 1.6 13697
CD38 4084 94.9 711 34 0.8 70226
CD40 3990 95.2 191 9 0.2 34346
CD41 3639 94.3 467 106 2.9 18510
CD43 3825 94.6 213 56 1.5 8182
CD44 3622 94.8 2428 2292 63.3 3633
CD45 4012 94.4 323 79 2 10254
CD48 4222 96.1 191 21 0.5 11203
CD49b 3782 95.2 131 5 0.1 794
CD49d 4420 95.5 147 16 0.4 1422
CD49e 4378 95.1 235 85 1.9 3211
CD51 4566 95.2 265 128 2.8 2339
CD54 4018 96 124 3 0.1 1085
CD55 3836 95.3 246 29 0.8 15442
CD61 4298 95.6 170 9 0.2 23642
CD62E 3944 95.1 156 20 0.5 7473
CD62L 4068 94.5 124 7 0.2 3984
CD69 2994 94.7 211 17 0.6 31004
CD71 3382 94.8 2895 2302 68.1 4106
CD73 4015 94.6 836 596 14.8 4757
CD80 4058 95.2 158 48 1.2 1638
CD81 4467 95.8 11050 3089 69.2 15869
CD86 3849 94.9 316 129 3.4 6131
CD90 4273 95.4 190 42 1 6482
CD90.2 4201 95.2 104 6 0.1 1449
CD93 4129 95.5 154 21 0.5 7079
CD95 2183 94.5 290 22 1 23639
CD103 3752 95.6 147 20 0.5 8488
CD105 2573 93.9 531 110 4.3 9072
CD117 2742 95.6 146 10 0.4 20683
CD120b 3859 95.3 155 13 0.3 773
CD121a 4211 95.5 147 9 0.2 8728
CD121b 3867 94.5 235 34 0.9 15088
CD122 3034 94.8 199 9 0.3 25478
CD124 3809 95.8 217 12 0.3 23626
CD126 4988 95.7 252 36 0.7 19941 Protein P1 #Eveπts P1 % Parent P1 PE (575/26) -A Mean P2 #Events P2 %Parent P2 PE (575/26) -A Mean
CD127 4236 95.9 425 75 1.8 17669
CD131 4270 95.9 176 17 0.4 11002
CD132 3927 95.5 120 16 0.4 3241
CD133 4377 95.5 172 68 1.6 5428
CD135 1899 94.7 163 25 1.3 2843
CD137 2867 95.7 67 18 0.6 3345
CD138 3688 95.3 187 51 1.4 3620
CD140a 4272 95.5 127 11 0.3 3494
CD140b 4301 95.9 127 20 0.5 2678
CD150 4567 94.9 139 4 0.1 10829
CD152 4620 95.4 347 70 1.5 16101
CD153 4467 95.3 249 86 1.9 6674
CD166 4226 95.2 1038 272 6.4 13867
CD178 4024 95.2 210 25 0.6 14600
CD 184 3962 95.4 211 43 1.1 13840
CD201 2538 95.4 5484 666 26.2 20381
CD202 2947 95.7 307 81 2.7 8919
CD212 2709 95.3 86 11 0.4 7440
CD273 4434 95.5 301 49 1.1 18034
CD274 4462 95.8 271 111 2.5 7659
CD284 4629 95.8 222 66 1.4 7447
CD309 3834 95.3 320 37 1 28476
Oct3/4 interne 3820 94.9 271 147 3.8 4247
Sca-1 3101 96.2 2236 1102 35.5 5931
CD45 4369 95.8 273 44 1 15082
CD45 4101 95.1 169 8 0.2 19338
Sca-1 4356 95.2 537 978 22.5 1716
Sca-1 3193 95.6 905 1184 37.1 2047
Table 7
Figure imgf000079_0001
Figure imgf000080_0001
Table 8
Growth factor combinations used in cultures of human expanded neurospheres (XS)
Figure imgf000081_0001
TABLE 9
° Raw XS pOS + 6 GFs „ Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l change GFs
26134763 17804309 1733 2686 NUP153
5 796 18767662 102 79762 116 77678 CDC25C CDC25
Fold Raw XS pOS + β GFe ^°S +"° Common Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l change GFe
4 671 84 88533 395 4768 230 7143 HMGBl
NM_007370
3943 1914006 75466226 73088643 SFRSl „ '«, " ' ' NMJJ01078166
3743 3129226 12126143 1435406 BAT3 G3, D6S52E NMJJ80703
3 11 14956429 465 1643 444 64758 ITGB3BP ™?™' "™?J"9' 0^"' NMJ314288
MGC26679
2 607 30697263 78657263 652 2101 CHEKl CHKl
2569 11737262 30145596 22089345 STX3
2 524 8048529 203 1726 19396011 CCDC5
Fθld Raw XS pOS + 6 GFe £°S +"° Common Synonyms Genbank Description Probe_Sequence Probe Id Probe SequβncθJ change v GFs
2021 39019763 7894143 805756 BRIX, FUlIlOO
2 O03 5984143 11964435 1251 6143 EX0SC3
1063 6226 2120 3977
1951 4498351 8777018 7973684 PRMTS !""' ""UfT?15' 'BP72' NM_001039619
5KBInS, JBrI
824 2726
1 796 91 647675 163 63512 132 34761
Fold Raw XS pOS + β GFe ^°S +"° Common Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l change GFs
0272 69372266 19178928 122 20595 SOCSl
00421 349 69763 17 690117 102 4527 KLF4
TABLE 10
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Geπbank Description Probθ_Sβquβnce Probe Id Probe SequenceJ
Homo sapiens fibroπectin leucine rich transmembrane protein 3 AGTGCATTGTACGCCCTTTGGCCAGT
3346367237 12910944 4320476 10284102 10384102 NM 198391 (FLRT3), transcript variant 2, CTTGTATGTGCCTTGATCCAACGC mRNA
GACAGTGTGGGGAAGTGTC
Hek6, EPHT2, NET, Homo sapiens EPH receptor B1 CAGACAGGAAACAGGTGAGTGGTTTG
2694332874 10906446 29385596 35249313 36249313 NM 004441 CCTGTGATCTTGGCAGTGGA ILMNJ 779794 FLJ37986, ELK (EPHB1), mRNA AATTGGATGCAGTGTGGGCCATCC ACATGCAAGGC
PREDICTED Homo sapiens solute
ATGGTGCATTCTGTAACCATGGAGTCT
2598898971 1028856 26738928 14040182 14140182 XM 001132419 carrier family 35, member F3 TCTGTTTCCTGGGGGAAAGGGGC (SLC35F3), mRNA
SgV, 7B2, P7B2, Homo sapiens secretogranin V (7B2 AGAAGGCTGTACTCAAGAGGAGGAGC
2359394326 446775 10541184 47015976 48015976 NM 003020 SGNE1 protein) (SCG5), mRNA TGACACATTTCACTTGGCTGCGTC
PTBLP, nPTB, nPTB7,
GCTGTGGATTACATCTTGTG PTB, nPTBβ, nPTB6, Homo sapiens polypyrimidiπe tract GTGGCAGTTTTCTAAAACTGACAACCA
1523240794 98 13929 14948977 13700643 1371 0643 NM 021190 TGTGTCAGAGAAACTGCAGA ILMNJ 712360 FLJ34897, MIBP, binding protein 2 (PTBP2), mRNA GGTGGGACCAAAGTTTATGTGCC GAACCTGGAG nPTB5, brPTB
KIAA1580, NGL1. NGL Homo sapiens leucine rich repeat TTACGGGAGACACACCCATGGAAAGC
1303930798 6671953 8699765 35 163696 36 163696 NM 020929 containing 4C (LRRC4C), mRNA CACCTGCCCATGCCTGCTATCGAG
Homo sapiens ovo-like GCCAAACCCCACCTGAAGCAGAACCA
1091868321 56919904 62 14904 22 580227 23 580227 HOVO1 NM 004561 1(Drosophιla) (OVOL1), mRNA CTTTGGCCTCCCCTGCCCAAAATG
STMP, PCANAP1, Homo sapiens six transmembrane
GTGTTGGCCAGTGAGATGAAGTCTCC
1027813522 36069866 37073096 15553513 15653513 STAMP1, IPCA1, IPCA NMJ52999 epithelial antigen of the prostate 2 TCAAAGGAAGGCAGCATGTGTCCT
1 (STEAP2), mRNA
Homo sapiens radical S-adenosyl vιg1, cιg33, CGCTGGAACCTTGGGCAAGGAAGAAT
10 19431299 6 5091376 66356186 49971592 50 971592 NM 080657 methionine domain containing 2 2510004L01Rιk, cιg5 GTGAGCAAGAGTAGAGAGAGTGCC (RSAD2), mRNA
Homo sapiens ATP-biπding
ABC37, FLJ36852, cassette, sub-family C CGAGTACACACTATTCTGACGGCAGA
10 12510993 7 253701 7344452 15674002 16674002 NM 020297 SUR2, CMD1O (CFTR/MRP), member 9 (ABCC9), CCTGGTTATTGTGATGAAGCGAGG transσipt variant SUR2B, mRNA
Homo sapiens dual specificity
GTTGTCGCAAAGGGGATAATCTGGGA
8991019535 94 28131 8476851 6096226 6106226 MKP3, PYST1 NM 022652 phosphatase 6 (DUSP6), transcript AAGACACCAAATCATGGGCTCACT variant 2, mRNA
GAATGGCAGGACCCTGAGTT
Homo sapiens hect domain and TCACCTTCCTCTGTACACTTGGAAATG
860146103 31 612083 271 9101 81 1853 82 1853 KIAA0032 NM 014606 GATGAGAGACGTGGAAGCA ILMNJ 729827 RLD 3 (HERC3), mRNA CCTCTGGCTTGTTGCAGCCCTCC GCCACAGGGCA
UKp68, FLJ11806, Homo sapiens zinc finger CCCH- GTAGCAGAAGAGGAGGAGT
GATGGTGTCCCCAGCCCCCCAGGATA
8 574296039 34 590996 29659344 363 56427 364 56427 MGC26892, NY-REN- NM_024824 type containing 14 (ZC3H14), GGCTACACAAACAAGCTGAG ILMNJ 812523 CATGTCAGATCAAGAGGAGGACAT
37 transcript variant 1 , mRNA GCACGAAGAGC
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe_Sβquencβ Probe Id Probθ_Sequence_l
Homo sapiens annexin A8 (ANXA8), mRNA XM_931361 XM_931369
XM_931374 XM_931375 GGCCATCCCAAAGCTATTCT
GGCCCTTATGTACCCGCCATACAGATA
8040458133 7 3495235 59093536 81 198135 82 198135 bA301J7 3, ANX8 NM 001040084 XM_931378 XM_931383 GGGGGCAACAGAGGTGAAA ILMN_1744914 CGAAGCCAAGGAGCTGCATGACG
XM_931388 XM_931391 CTACTGGGCCA
XM_931399 XM_931404
XM_931411 p53BP2, ASPP2, Homo sapiens tumor protein p53 CTCCTGGATAGTTCCAAACA
CATCATGTTGGCCAGGATGGTCTCGA
7 844616811 24 109648 189 13095 381 7976 382 7976 53BP2, PPP1R13A, NM_005426 binding protein, 2 (TP53BP2), TCTTCCTTGTGGCAGGTTTC ILMNJ 724487 TCTCCTGACCTTGTGATCCGCCTG
BBP transcript variant 2, mRNA CTGGCTGAGC
Homo sapiens ATP-binding cassette, sub-family C AGACGTTCGGGGCAGGGTG
ABC37, FLJ36852, CCTGGAGGTCTAGATGCGGTTGTCAC
7644057119 11 707075 8948955 46772972 47 772972 NM 020298 (CFTR/MRP), member 9 (ABCC9), GGAGTGGGTATGGAGATGC ILMN_1664896 SUR2, CMD1O TGAAGGTGGGGAGAATTTTAGCGT transcript variant SUR2A-delta-14, AATTTGGGACTG mRNA
Homo sapiens protein kinase (cAMP
CTCCTTGCAATCATGTGGACACCAATC
7025617547 40647335 28557263 33038095 331 38095 PRKACN1 NM 006823 dependent, catalytic) inhibitor alpha ACAAAAGTAAAGCCCTGGTGTTG (PKIA), transcript variant 6, mRNA
CTTGAGTGTCTTGCTGAGGG
Homo sapiens nucleoporin 153kDa CACTGATTTGACATAGTCTGGCTGTAC
6812500653 261 34763 17804309 17332686 17342686 HNUP153, N153 NM_005124 TTACTGTATCTAGCAGGTGA ILMNJ 750412 (NUP153), mRNA CCAGGAATGGAGCCTGCACGGTG TGGAGCTTGG
FLJ21474,
MGC119474, CTCCCAGCCATCTCCTCTTC
Homo sapiens SATB homeobox 2 GCAGTGGTTCTAAGTGAATCTGTGGG
6501949884 11673512 7590059 494 1601 495 1601 FLJ32076, NM_015265 CCTAAGGCCTCTGTCTCCAT ILMNJ 804993 (SATB2), mRNA CATTTTAGCCTGTGGTCTTGCCAG
MGC119477, AGCTCTGGTT
KIAA1034
CCCAGCAGGGCCAGGTCGG
Homo sapiens legumain (LGMN), TGGCACAATCTTGGCTCACTGCAACCT
633186362 11 402901 72201614 229 13097 230 13097 AEP, LGMN1. PRSC1 NM_0O1O08530 AAGGTGATTGAATACAAAAG ILMNJ 804444 transcript variant 2, mRNA CTGCCTCCCGGGTTCAAGCAATT CACCAGGGACC TCCCCACTCTAAGCACTGCC
Homo sapiens arylformamidase GGCGTGAGCCACTGCGCCCGGCCAG
5766845981 9651041 55656067 68971115 69 971115 KF, DKFZp686F03259 NM_001010982 TCCCCTACTCCCCGCATCTT ILMNJ739605 (AFMID), mRNA AATGGCATTATATTTAAATAGTTCA TGGGGAATCG
Homo sapiens nuclear receptor
NY-SAR-105, GCCAAGACTCCCATGCTGCCTCATTTG
5258358801 18726012 9846809 764 9143 7659143 NM 020645 interacting protein 3 (NRIP3),
C11orf14 TATTCAAGCCTTTAACAGGAGGG mRNA
Homo sapiens nucleoporin like 1 ATTACTGTACATAGAGAGAC
GTTACTACTGGACCCACTCCTTTCAGC
5 108507008 3476181 177 58095 18365594 18465594 PRO2463, KIAA0410 NM_014089 (NUPL1), transcript variant 1, AGGTGGGCAI I I I I GGGCTA ILMNJ 735930 ACCATGCCAAACGCAGCAGCCGT mRNA CCTGGTTCGT CAAGTCTCAAGAGACACTTA
FU10545, C6orf139, Homo sapiens centromere protein Q GCCAATGGCTTACAGTTTCTGTCTGGT
4964831302 5759127 28593094 19349762 19449762 NM 018132 ATTCAGATGACTTGGATGCC ILMNJ720955
CENP-Q (CENPQ), mRNA CATCTGGAACTTGAAAAATCCTC ACTGACAAAC
Homo sapiens regulator of
AGCGCCGGAGTTCCTTGTGGCCGACG
4863801288 16468401 8009903 9807051 9907051 RCC1-I, CHC1 NM_001269 chromosome condensation 1 TGCACCAAGGACAGGAAGATGTCA (RCC1), transcript variant 3, mRNA
GTCCAGATGAGAGCAGAGAT
Homo sapiens histone cluster 1 , TGGGACTCTTCGAAGACACCAATCTGT
4622106413 11 189314 51 7182 7605653 7705653 H3/C, H3FC, H3 1 NM_003531 ACAGTGAGAAATTATGTGAT ILMNJ 742324 H3c (HIST1H3C), mRNA GCGCTATTCACGCTAAACGCGTC CTGTGTGTTG
Fold change XS XS-i- β GFs pOS +no GFe pOS +no GFs Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens solute carrier family 25 (mitochondrial earner, adenine
PEO2, ANT1.PEO3, GTGCCTGGTCCAATGTGCTGAGAGGC
4283732806 15946309 68309727 8530181 8531 181 NM 001151 nucleotide translocator), member 4 T1.ANT ATGGGCGGTGCTTTTGTATTGGTG (SLC25A4), nuclear gene encoding mitochondrial protein, mRNA
RDJ2, DNAJ, DJA2, Homo sapiens DnaJ (Hsp40)
AAAAAATGGGCTTTGCACACAATGGGT
4135770497 21504392 8893723 10224697 10225697 DNJ3, HIRIP4, NM 005880 homolog, subfamily A, member 2 TTGGAGCTGACTGGGAACAATGG PRO3015, CPR3 (DNAJA2), mRNA p40, PRKM2, MAPK2, PRKM1, p38, p41, Homo sapiens mitogen-activated
GTAGAACAGGCTCTGGCCCACCCATA
3978921515 20603094 81978094 100714764 100814764 ERK, ERT1, NM 138957 protein kinase 1 (MAPK1 ), transcript TCTGGAGCAGTATTACGACCCGAG P42MAPK, p41mapk, variant 2, mRNA ERK2
Homo sapiens v-ral simian leukemia CACCTGT AATCCGACTGT AA
GCTTTGAGACCTTTCCTCTCCTGGGTA
3866772299 19235309 7437856 32082976 32092976 MGC48949, RAL NM 005402 viral oncogene homolog A (ras GCTCATCACCTTGGGAGGC ILMNJ 669201 CTGAGGTGCTATGAAGCCAACTG related) (RALA), mRNA CACTGTAGGAG
Homo sapiens SEH1-lιkβ (S CCTACTCATCCAAGACCCAG
Sβh1, SEH1A, ATGCTGACACTGCCAACCTCCAGTATC
3772072238 29478094 1111935 11781309 11791309 NM 001013437 cerevisiae) (SEHU), transcript CTTCATTGTCTCCATCTCTG ILMNJ 717195 SEC13L, SEH1B CTCACCCTCGCAGACGATATCTC variant 1 , mRNA GGAAGCCTGC
Homo sapiens family with sequence
GCCCTTCACTCCCACCTGCTGCCAAA
3762270598 57965594 21808225 25453892 25463892 C5orf6 NM_016605 similarity 53, member C (FAM53C), GTCCCTGTGCTAATGGGATTACAA mRNA
GGCAATACCTGATGTCAGTC
FLJ14724, FLJ10430, Homo sapiens neuropihn (NRP) and GTTCACATCAGTGGCTTTGTATGCAAA
3761254149 16311429 6135143 5847726 5857726 NM 018092 ACAGGCATCCAACTCATGAC ILMNJ 811050
NEOT2, FLJ90456 tolloid (TLL)-hke 2 (NETO2), mRNA TATGCTGTGTTGGACCTGGACGC
AAGAGATACC
AATGCACCTCATTCTTCCCT
MGC130009, SPR-1, Homo sapiens Sp4 transcription ATGCATGTCACTAAGTTGTCATCCCAC
33885441 4057228 13748096 10475186 10575186 NM 003112 GGCCTCTTTCCCACCCACAG ILMNJ 732323 HF1B, MGC130008 factor (SP4), mRNA ATAAATTGATGTGCAGCATAGGG
CCCCCAGAGG
Homo sapiens Usher syndrome 1G TGGATAG I I I I I I GCCCTATT
ANKS4A, SANS, TGCCTGCCACCGCCATCTGGAGCCCA
3373783841 23652443 7979823 7215463 7315463 NM 173477 (autosomal recessive) (USH1G), GAATCATTCAGTTGGTGTAC ILMNJ 799843 FLJ33924 CCACAGCTCTTCTCCCTGTTCTCT mRNA AAACATGCC
Homo sapiens v-abl Abelson murine
FLJ31718, ABLL, leukemia viral oncogene homolog 2
3309017321 2525606 8357274 22341427 23341427 ARG, FLJ22224, NM 005158 (arg, Abelson-related gene) (ABL2), FLJ41441 transcript variant a, mRNA
M11S1, p137GPI, Homo sapiens cell cycle associated
322653257 71698926 23133892 2875356 2876356 GPIP137, GPIAP1, NM_005898 protein 1 (CAPRIN1), transcript caprιn-1 variant 1 , mRNA
Homo sapiens SH3-bιndιng domain
2907064608 24711845 7183893 2822393 2832393 FLJ33845, KIAA1720 NM_030645 protein 5-lιke (SH3BP5L), mRNA
Homo sapiens zinc finger protein
2883793461 12571685 36254143 4412081 4413081 DKFZp761N202 NM 001032293 207 (ZNF207), transcript variant 2, mRNA
Homo sapiens chromosome 19
2867175551 17842679 51158093 4979018 4989018 MGC13170 NM 199250 open reading frame 48 (C19orf48), mRNA
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe Sequence Probejd Probe_Sequence_l
Homo sapiens solute carrier family 25 (mitochondrial thiamine
TPC, MCPHA, DNC, pyrophosphate carrier), member 19 ACACTCCTGGTCTGGATGGGGCTGCT
2766789751 2996322 8290193 6949157 7049157 NM 021734 MUP1 (SLC25A19), nuclear gene GCTTGAGTGCAGAGGGCTGCGGTA encoding mitochondrial protein, mRNA
MGC120612, ARL2L1,
DKFZp761H079,
Homo sapiens ADP-πbosylation GAGCGGGCAAAGGAAATGT
MGC120611, CTTGGAGTTTGTACATGGGACTTAGCA
2757929189 265355 7318303 32136074 33136074 NM 144996 factor-like 13B (ARL13B), transcript GACAAGGAGAAGAAAGAAGA ILMNJ 680379
DKFZp686M2074, ACCACACTGAGTGAGGTAAAAGC variant 2, mRNA CACACTTGGGC
DKFZp686L2472,
DKFZp686E2075
Homo sapiens ATPase, Ca++
DAR, ATP2B, transporting, cardiac muscle, slow GCTGAACGTGACCCAGTGGCTGATGG
2724976168 12709644 34633477 33960977 33970977 MGC45367, DD, NM 170665 twitch 2 (ATP2A2), transcript variant TGCTGAAAATCTCCTTGCCCGTGA SERCA2
1, mRNA
Homo sapiens poly(rC) binding
MGC110998, CCACCCATGATCCATCTGTGTAGTTTC
2705198935 9985873 27013773 29913398 29914398 NM 005016 protein 2 (PCBP2), transcript variant HNRPE2, hnRNP-E2 TGAACAGTCAGCGATTCCAGGTT
1, mRNA
Homo sapiens EDAR-associated
GCAACATTTGTAGGGGCCGCTGCTAG
2694008456 58268852 15697678 22590594 22690594 ED3, EDA3 NM 145861 death domain (EDARADD), TTAGCTACCCTTGCCCACCGCCGT transcript variant A, mRNA
CGGAGCACGGAAGCACACA
Homo sapiens chromosome 5 open AGGAAACACAACTGGTTACCTATGAGA
2690585215 213 33095 5739851 48001013 481 01013 FLJ25291 NM 033211 CAAGCTCTTTATGAATTCTG ILMNJ 810593 reading frame 30 (C5orf30), mRNA CCTGTTCTGTCCGTGTGCCTACG CTCTCCATCAG
Homo sapiens striatin, calmodulin ATAGCCCAAAGAGTATGGTTAACTTCA
2667056556 29329708 7822399 54 512367 55 512367 MGC125642, SG2NA NM_003162 binding protein (STRN), mRNA CGCAGCTGCTTTTGCAGAAGCAC
Homo sapiens syntaxiπ 3 (STX3), GGCCGGTCACAATCCAGCACTCAGAC
2568366967 11737262 301 45596 22089345 221 89345 STX3A NM 004177 mRNA AGAGCCAAGGCAATATCCTCTTGC
Homo sapiens 0-sιaloglycoprotθin TGTACTGTGCTAGTGACTGG
CGTGCTGGCTTGGGCATTTTACATGA
2 557956172 4249556 10870178 124 77261 12577261 NM_022353 endopeptidase-hke 1 (0SGEPL1), AGGCCCTGCTACTGCAAATA ILMNJ666904 CATAGAAGGCATCCGCTATGAACC mRNA TAAAACCTAA
Homo sapiens glucosamine- CCACTAGCCCCTTACCCAGA
Gpnatl, GNPNAT, GGTGATCTTAGATTTGATGAAGCACAG
2 547248747 71 61555 182 42262 11304346 11404346 NMJ 98066 phosphate N-acetyltransferase 1 GTGGCCCACAGGAAACAGC ILMNJ699599 FLJ10607 TATGCAGGTAGGCCTAATGGGGG
(GNPNAT1), mRNA CTGCACCATTT
Homo sapiens ubiquitin specific ACATGTCCTGGGTGACATGG
MGC3394, USP16, CGGAGAATGCCCCAGTGTGTGACCGA
2545708766 187 31429 47684763 5938976 5948976 NMJ312475 peptidase 21 (USP21), transcript GATGTGACTTTCGGGTGTCG ILMNJ717702 USP23 TGTCGGCAGAAAACTCGAAGTACC variant 1 , mRNA GGGCAGCATG
Homo sapiens zinc finger, DHHC- TGTCAGGACGCGGAAAGCA
GGACAGGATTCGATTAAGTATTCCCTC
2 538535884 49395973 125 39345 67 78848 6878848 ZNF372 NM_016353 type containing 2 (ZDHHC2), GGGAGGCAAGGCCCGCGCT ILMNJ 747589 TTGTCAAACTGGAAGCTAGGGGA mRNA AAGGCCAAGTCG
Homo sapiens coiled-coil domain
FLJ40084, HEI-C, TAGTAAAGTGGCGGGAGCCGCAGCTA
2 524344511 8048529 203 1726 19396011 19496011 NM 138443 containing 5 (spindle associated) FLJ21094, HsT1461 TGGAGCCGCAGGAGGAGAGAGAAA
(CCDC5), mRNA
Npn3, SRX1, Homo sapiens sulfiredoxin 1 GGCCAAAGGAGCAGCTGTG
GGCAGGCCTTGTTCTCACTGCCCTCT
2479860984 409 16846 10146809 1091 781 1092 781 C20orf139, YKL086W, NM_080725 homolog (S cβrevisiae) (SRXN1), GAAGTGAACCTAAACACAAT ILMNJ 721926 AAGGGAACTTGGTCACTCGGCACT dJ850E92 mRNA GACAAGTGTGG
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probβ_Sequβncβ Probejd Probe_Sequence_l
GGCAGGAACCACCTTCCTCC
FRMD4, KIAA1294, Homo sapiens FERM domain CCCCATCCAGGTGCTATCAGATGACC
2475289645 18862679 46690594 332 88928 33388928 NM 018027 AAGATCCTCACTATGGCAAC ILMNJ 762170 bA295P94, FLJ10210 containing 4A (FRMD4A), mRNA AGTTACTGCTTAGTTAACTAGGTG TGTGGACCCC
DKFZP547N043,
Homo sapiens chromosome 1 open TACCAGACTCCGACACAATG PRO4323, DDDL1880, GGGTGCTACATTCACTCTTGCCTTAGG
2475199096 6372792 157 73929 14822263 14922263 NM_001010984 reading frame 124 (C1orf124), GGCCACCACCAGTGTGACA ILMNJ 804419 dJ876B10 3, RP5- TATACTGTAACCCAGGTTCTGCC transcript variant 2, mRNA GCAGGACATCC 876B10 3
MGC3331. MSSP-1, Homo sapiens RNA binding motif, MSSP, YC1. SCR2, single stranded interacting protein 1 TAGTCCGACTTCACCCATGGTGTTCTG
2451653597 761 8726 18678477 15824226 15834226 NM 002897 MSSP-3, MGC15146, (RBMS1), transcript variant 3, TGCTTGCAGTGCGAGTGTTGCTG MSSP-2 mRNA
TCTTAACCAGCTGAGGGAGC
MGC22671, Homo sapiens popeye domain CAGCCTGAGGGTGGGTTGCTACTGTC
243551012 12745178 3104101 21801428 21901428 NM_022361 TTGTACAACACCTTATGTATG ILMNJ805148 bA355M14 1, POP3 containing 3 (POPDC3), mRNA CACATAGGCATTTCCGGAATTCAC CTGGTTGGG
Homo sapiens protein
GTAGGGGGATTTGCCAAGTGGCCAGA
24025985 54 894432 131 88928 1122518 1132518 BGGI, GGTI NM 005023 geranylgeranyltransferasθ type I, CAGTCATCCAGATGCTTTGCATGC beta submit (PGGT1B), mRNA
GTAGAACAGGCTCTGGCCCA
Homo sapiens transmembrane ACCTAGGATGGGGTTTCTCTAATTGCT
2400318237 40988365 9838512 9849486 9949486 FU10846 NM_018241 CCCATATCTGGAGCAGTATT ILMNJ 767320 protein 34 (TMEM34), mRNA AATCACAACCCCACTGGGTCATG ACGACCCGAG
Homo sapiens aldo-keto reductase
ALR. ALDR1, family 1 , member A1 (aldehyde ATCTTGCTCAGGTGGCAGGTCCAGCG
2 393387444 1211 5768 28997727 3621 2559 3622 2559 MGC1380, MGC12529 NM-006066 reductase) (AKR1A1 ), transcript GAAAGTGATCTGCATCCCCAAAAG variant 1 , mRNA
Homo sapiens inosine
HLC14-O6-P, triphosphatase (nucleoside AGAGGCTGCCAGGACTTTGGCTGGGA
2384570378 40344345 9620393 1094 1726 1095 1726 dJ794l63, ITPase, NM_033453 triphosphate pyrophosphatase) CCCCTGCTTTCAGCCTGATGGATA
C20orf37 (ITPA), transcript variant 1 , mRNA
MGC163279, IRE1, Homo sapiens endoplasmic
ACTGACATGTGTGTGCCTGAGTGCCA
2 347559778 64 37612 151 12679 94 044495 95044495 IRE1P, FLJ30999, NMJ 52461 reticulum to nucleus signalling 1 GCCACCGTGTGAACTCTTTGGAGG
MGC163277 (ERN1), transcript variant 2, mRNA
Homo sapiens katanin p60 subunit AACGCCCCGGGCAAAGGGT
TCATATGATGGTACGGCAGCAGGGAG
2 3319628 273 35596 637 45593 452 7851 453 7851 MGC2599 NM 001014380 A-hke 1 (KATNAL1), transcript CTTTTGCAGCTTTTGCAGAC ILMNJ 753550 TGGCCCCCAGTTAACATGGCTGTG variant 2, mRNA GGGCAAGAAGC
Homo sapiens hepatoma-deπved AGGCAAACACAACTCTTGAC
TAAAGCTGGAATCAGCAACAGCCCTAT
2298844153 327 18512 752 1476 472 37262 473 37262 HDGF2, CGI-142 NM 016073 growth factor, related protein 3 TGCCCTCCCACCCTCCTACC ILMNJ764617 GGGAAACCAGACAAAGCATTGAC (HDGFRP3), mRNA TGTTCAGTAC Homo sapiens asparagine-linked
YGL047W, GLT28D1, AGGACTTACTATTGI I I I I IAAGGATCT
2284190884 45755493 104 51428 8625282 8725282 NM 018466 glycosylation 13 homolog (S MDS031 CCTCTCACAGTGGTAATGAAAC cerevisiae) (ALG13), mRNA Homo sapiens heterogeneous
MGC102835, nuclear ribonucleoprotein A1 TTATGGAGGAGGCGGCCCTGGTTACT
2267744374 130 13928 29512262 25440594 25540594 NM_031157 HNRNPA1 (HNRNPA1), transcript variant 2, CTGGAGGAAGCAGAGGCTATGGAA mRNA
FLJ12673, PRMT9,
Homo sapiens F-box protein 11 TCCCCCCAGTCATATCTCAT
UG063H01, CAATACTTTTCCTTTTGTAGCCACTTTG
2258477032 41 58118 9391014 7644257 7744257 (FBX011 ), transcript variant 2, GATTTCCACAGTTGTTGTATT ILMNJ 808636
MGC44383, FBX11 , - AGTCTGCAGTTGTCAGTAAGCC mRNA GGTGTGGAG
VIT1
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Gβnbank Description Probe_Sequence Probejd Probe_Sequence_l
CGCCTGGCCTATTGAAGGTT
Homo sapiens sβptiπ 10 (SEPT10), GCACTGACTTGACCCCACAAGTGGAA
2 226506517 106 15178 23634763 171 78094 172 78094 NMJ 44710 TTTAATCTTCAGAGTTTCGAC ILMNJ 658713 transcript variant 1 , mRNA AATTCCCCACCCGACACCTTTGCT TTTATCAAC
Homo sapiens hypothetical protein AGGGCAGCCTCTGTTGGCCTGAGGGT
2223727465 16494345 36678928 25631427 25731427 MGC99481 NM_138353 BC002926 (LOC90379), mRNA CTGGACGCTTTTTATTTATGCCTA
GCTCAAGGAAAGATAAAGCT
Homo sapiens KIAA0182 CCGGTGCCTCGGTCACTCTGGGGGCA
2 157742534 217 96011 470 3018 481 2976 482 2976 GSE1 NM_014615 GGGCGGAAGGAGGTGTGCG ILMNJ 700681 (KIAA0182), mRNA GTTTAGATGCTGTGAAATTAAACC
TGGCTTCTGGG
Homo sapiens chromosome 16 TTTTCTATCAACAATTGGGAA
AGCAGAGGGGCCCCGGAGACAGCGG
2 153210771 31 19235 67 163704 39281055 40281055 MGC21830 NM 182563 open reading frame 79 (C16orf79), ATGCTTATACATGTAAATATG ILMNJ673815 CTGATTTATCTCTGCATCGACATCT mRNA AAAATGTT
Homo sapiens UbiA AAGCTGGGTTGTGTACTTTC
GGAATGTGATTTGGCAGTCAGGGTAC
2 144857526 110555954 237 12677 22832262 22932262 RP4-796F18 1. TERE1 NM_013319 prenyltransferase domain containing TGGTGACACTCCTGGGCTCC ILMNJ793033 TAAGCATGGGTGGGAACTCCTGCC
1 (UBIAD1), mRNA TCCCCATCCC CAGTGGAGAACCAAGCCCC
Homo sapiens cadheπn 13, H-
2 134165271 19623096 4187893 206 35178 207 35178 CDHH NM 001257 ATGGCCTCAGAATTTCCCCC ILMNJ 700770 cadheπn (heart) (CDH13), mRNA GCTCGCCACGAACTAGGGTAAGG CAGTTCCCCAA
Homo sapiens similar to RIKEN
MGC150539, CCAGAAGCTTTATCATCGGTTATTAAG
2094395317 14286429 2992143 30497263 30597263 NM 001071775 cDNA 2410129H14 (LOC440145), FLJ21869 GAGCTTCGCAAGGCTACTGAAGC mRNA
COD1. CORDX1, Homo sapiens retinitis pigmentosa CTGAAACTCCCTTGTGTTCC
GATGCCGACCAGAACCACATGAGTCA
2092095105 6635977 13883095 71 15883 72 15883 XLRP3, RP15, CRD, NM_001023582 GTPase regulator (RPGR), TTCTGTGAAGAAGCCCTGTT ILMNJ 753613 GAATCATCAGAATATCCCACCAAC orf15, PCDX, RP3 transcript variant B, mRNA CTCGTTGCCC
AGCGAGGCACCCTTACTGG
Homo sapiens paxillm (PXN), ATGACCAGAAAGGGGCCACCGGGGTC
2075133114 127 13928 26383093 36334763 364 34763 FLJ16691 NM 002859 CTTACCTCCTCATGGCAGCC ILMNJ 725560 mRNA TAATGGTGACAGTCCAAACCACTC TACTCTCCTTG
Homo sapiens zinc finger protein
ACTGTACCCGGCATGAGAAAACCCAC
2074732756 32976276 6841696 48 57859 49 57859 MGC45293 NM 198088 200 (ZNF200), transcript variant 3, TCAGCCTGTAAGACCCGAAAGCAG mRNA
CATGTATCGGAACTTAGAAC
PZF, FKSG11, Homo sapiens zinc finger protein 91 GAAGAAGGACAGCGTAGTGGCACACA
2 050050516 41 88808 85 87268 10483512 10583512 NM 053023 TGGTGGGCGCGGTGGCTCT ILMNJ 661519 ZNF757 homolog (mouse) (ZFP91), mRNA AGGCAAAAAGCCACCCTGAGGTGC TGCCTGTAATC
Homo sapiens mitochondrial ribosomal protein L3 (MRPL3), GTGAAATAGTGGTTGTGGAACAGTAG
2 038574951 45404335 92 56014 75 18869 76 18869 MRL3, RPML3 NM 007208 nuclear gene encoding AAAACCATATGGGGACTATAGTGC mitochondrial protein, mRNA
CACTCTATGGGAAACTCTTC
Homo sapiens chromosome 1 open TATACCTGCTCTATGTGGGTGCTGCAT
2 010135763 48944515 98 38512 102 126785 103 126785 FLJ25078 NM 152485 AGCACCTACCTGCGCCCCC ILMNJ674759 reading frame 74 (C1orf74), mRNA GCTAGGAAAGTAGGGCTGGGGGC CACACACCTCT
DKFZD686M1969,
FLJ90492,
Homo sapiens transmembrane and TTCCATACTGCAAGGGCAAC
DKFZp686O2342, CTGATACCAGTGGGAGTTGGTCTTGA
1 991629516 131 62679 262 1518 182 15594 183 15594 tetratπcopeptide repeat containing 3 GTCATACCCCACACCTACTG ILMNJ 770442
DKFZp686O22167, NM-181783 TCTAGGAGATTCTGTTAAGCATCC (TMTC3), mRNA TGACCACATG
DKFZp686C0968,
SMILE
MGC75174, Homo sapiens La ribonucleoprotein GGAAAGGCTGCTCTTGCTCT
TTCTCTGCAGGGTAGGTAAGATAGGT
1 990849952 164 5893 327 6726 24674762 24774762 DKFZp686L13217, NM_032239 domain family, member 2 (LARP2), CCCTCCCAGGGCTTGAGGC ILMNJ697081 CAGTCAAGTTGGTAATGCCTGTCC
MGC 117277 transcript variant 3, mRNA TCCCTATACTT
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Gβnbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens serpin peptidase
GCTGCTGCCCACACCGCGT inhibitor, clade B (ovalbumin), AGGAGCTGAGCATGGTCATTCTGCTT
196831009 24658511 48535598 36212262 36312262 CAP2, PI8 NM_002640 CGACGCCTTCACTGCCATCC ILMNJ 738473 member 8 (SERPINB8), transcript CCCGATGACAACACGGACCTCGCC CCGCTGTCCTT variant 1 , mRNA
NAP57, NOLA4, Homo sapiens dyskeratosis GGGGAGGAAGACACCTCAT
GTACAGTGCTCACCTAAATCCATCTGA
1967603512 14154559 2785056 23462144 23472144 XAP101, dyskeπn, NM_001363 congenita 1, dyskenn (DKC1), ATCAGCCCTCAAAGGCTCCC ILMNJ 686587 CTACTTGTTCCTGTGCCCTCTTG
DKC mRNA CTCACTGTCTC
Homo sapiens ribosomal RNA GCTAATAGCCTAACTGCAGA
KIAA0507, CGI-115, CTGCTTGACCAGCGAGATGTGCATTTT
1960293978 5412101 10609309 100588513 100688513 NM_016052 processing 15 homolog (S GGAACTGAGTGGATGGGGT ILMNJ 790008 MGC22291 GCCAGGATCATATTGGTCATGTC cerevisiae) (RRP15), mRNA AGCTGCTGTAT GTGCGACCTCGATCTGTCCC
SPD, BDE, HOX4I, Homo sapiens homeobox D13 CCAGGTTGGCCACAGACAGCTTAGAA
195255194 69454895 13561429 13241846 13341846 NM_000523 AAGCATTCATGTTCCCTCAC ILMNJ757336 BDSD (HOXD13), mRNA GCCATTCGGTTGTCTCCAAAAGGC CAGCTGTAGT
Homo sapiens protein arginine
SKB1. HRMT1L5, GGTGCAGTACATCTATGGGCTGTGAT
1951163437 4498351 8777018 7973684 7983684 NMJ301039619 methyltransferase 5 (PRMT5), IBP72, SKB1HS, JBP1 TCCCCTTGCCCATCAGAGAGGAGC transcript variant 2, mRNA
Homo sapiens transmembrane GAGGCTTGCTCCTATGGCTCCATTCCT
1936256195 9220143 17852559 24372893 24382893 HP10481 NMJ314254 protein 5 (TMEM5), mRNA GTGGTGGAAGACGTGATGACAGC
CIP3, Rrp43p, EAP2, OA421P11 3, RRP43, Homo sapiens exosome component GGCAAACTCTGTTGTCTTCACAAACCA
1931251388 70070593 13532393 11584642 11594642 NM 181503 OIP2, RP11-421 P11 3, 8 (EXOSC8), mRNA GGTGGAAGTGGGCTAACTGGAGC P9
Homo sapiens NIMA (never in
CAAGGGAGAAGGTATAGTGGAATGAG
1919072538 73619385 14128094 8888519 8988519 MGC29949, HSPK36 NM_152720 mitosis gene a)-related kinase 3 TGTGAGCATCGGGCTTTGCAGTCC (NEK3), transcript variant 2, mRNA
Homo sapiens solute earner family
CTGACCAAAGCATGTTTTAAGCTGCAA
1915002084 11884762 22759344 14151428 14251428 ACATN, AT-1 , AT1 NMJ304733 33 (acetyl-CoA transporter), TGCAGTAGTCACGGGTGGTAACC member 1 (SLC33A1), mRNA
Homo sapiens ubiquitin-activating
GTGATTGGGAATGGATGGG
FU23251Uba5, Uba5, enzyme E1 -domain containing 1 GTTTGGAGACTCATAAATACCATGCAG
190775658 6610607 12611429 81873 82873 NM 198329 GGACAGTGAGGAGGACACA ILMNJ798690 FLJ23251 (UBE1DC1), transcript variant 2, GTGTAACCACTGCCAATAGGCTG CCAGCCCATTAG mRNA
Homo sapiens small nuclear ACCCCCGCGCTCCACCTGC
GGCTGTTCAGCAGAGAAACCCATGTC
1884910481 40941895 77171807 75930645 75940645 MGC117317, SMG NM_003096 πbonucleoprotein polypeptide G AGTGTTTCTGCCCTGTAAAT ILMNJ 659599 CTCTCTCCATAGGGCCTGTTTTAC
(SNRPG), mRNA AGGACCAGTCT
KIAA1646, dA59H18 3, hCERK,
TGCATTTGTTTATGTAATTTC dA59H182, FLJ23239, Homo sapiens ceramide kinase GCTCTGATTTCCGGGGCAGCCTTTCA
1881696537 53370593 10042726 9514435 9524435 NM 022766 . « oM« AGGAGGAATACTGAACATCT ILMN 1791466 MGC131878, LK4, (CERK), transcript variant 1, mRNA GAGTCCTGG GATGCGGCAGACATACAACACCTG FU21430, DKFZp434E0211
RA-GEF-2, DKFZp686l15116, Homo sapiens Rap guanine CTCTCGCTTGCTCTCTCTCA
TTCTGCAGCATGCCTCCCCCACATCTC
1872783601 10809762 20244345 19383511 19483511 DKFZp667N084, NM 016340 nucleotide exchange factor (GEF) 6 CCATGTGACACACTGGCTCC ILMNJ718309 ATAGCACCAGGTTGTGTCTGACC PDZGEF2, PDZ- (RAPGEF6), mRNA CCTTCACCTT GEF2, KIA001LB
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe_Sequence Probe Id Probe_SequenceJ
GAGAGAGACCCGTTTCCTTT
Homo sapiens glypicaπ 6 (GPC6), ACCGGGTGCCAGACTGAACTGCTTCC
1 872208993 4869568 91 16849 11397262 114 97262 MGC126288 NM_005708 CAGGGATGTGGACAGGGTA ILMNJI 787922 mRNA TCTTTCCTTCAGCTATCTGTGGGG AGGGCAGCAAG
Homo sapiens glutathione S- GGGACTTCCCTTGACTGGGT
P28, GSTTLp28, GACTGGCAAGGTTTCCTAGAGCTCTA
1 867771311 5084048 9495839 6432231 6433231 NM 004832 transferase omega 1 (GSTO1 ), TGTGTTTCTTTTCCTGCCTCA ILMNJ 796288 DKFZp686H13163 CTTACAGAACAGCCCTGAGGCCTG mRNA GCCCAGCTC
GCGGTGTCAGCCTTTTCTTC
MBDIN. ATPBD1A. m ∞72&. Homo sapiens XPA binding protein GCCTCTACTCCCCCAGCTTCTTGCTCT
1 813808153 60473926 1096881 11642726 11652726 AGAGCATTTGTTTGACTGAC ILMNJ 682910 NTPBP 1, GTPase (XAB1), mRNA TGACCCTGCACTGTAAGTTGCCC TTCCAAAGCA
TGCAAGGGACAGGGGGCCT
Homo sapiens chromosome 9 open CTTCTGTCCCCCTTATGCCAACAAGAT
1 792543021 123 78928 221 89761 162 55594 163 55594 CG-8, FLJ20457 NM 017832 GACTACCCAGTCTTTGACTT ILMNJ 749006 reading frame 6 (C9orf6), mRNA GGCCTTCCCCTCTGAAACAAAGT GTATCCTCTCC
PP1. IOPPP, GCCTTTATGGGTGATCCAGG
Homo sapiens pyrophosphatase GAGAGCCCCTTCAAGTGTGATCCTGA
1 790955641 5437 798 9738855 9947 848 9948848 MGC111556, PP, SID6 NM_021129 GAAGATTGGTTTTGCTGATC ILMNJ 745529 (inorganic) 1 (PPA1), mRNA TGCTGCCAGAGCCATTGTGGATGC
8061 AGATTCCACC
Sthip, SNF2L2, SWI2, Homo sapiens SWI/SNF related, FLJ36757, SNF2, matrix associated, acttn dependent
1 763483907 1092 3392 19263226 1893 5892 18945892 BAF190, MGC74511, NM_003070 regulator of chromatin, subfamily a, GTTGCAAGTCATAAGCCTGAGGC BRM, hBRM, SNF2LA, member 2 (SMARCA2), transcript hSNF2a variant 1 , mRNA
Homo sapiens membrane-
CCTGCCAGGGAAGGCCACTGGGTGTT
1 748632897 10289644 1799281 1572 7935 15737935 NM_020814 associated ring finger (C3HC4) 4 CACCTGCAAAGTTTCTGGTTGTCA (MARCH4), mRNA
ZNF-U69274, Homo sapiens zinc finger and BTB CAGATACAACTACGGGGTTG
CAGCTGTGTGGCTGACTTTCAATTTTA
1 74507554 4855436 84731026 47 989887 48989887 FLJ13426, NM_014415 domain containing 11 (ZBTB11 ), TGGAGAGCTTCACAGTGCAG ILMNJ 752592 AGACGTGAATTGACATACAGCCC MGC 133303 mRNA CGGCGAGTCC
Homo sapiens target of myb1-lιke 2 AGGGACCGCTTGGAGCAGT
TGGCACGCTGCTGAGACGACACTACC
1 742671384 86 19772 1502143 185 10596 186 10596 FLJ32746 NM_001082968 (chicken) (T0M1L2), transcript TAGAAAGGAAGCGGGAGCG ILMNJ711078 AATAAACCAAACTGCCACGCACAC variant 3, mRNA GGAGCGCAAGAT
Homo sapiens TNF receptor-
TATTAGTGCGCTGTGAGGTCTCCACC
1 720888068 73981735 127 314285 10072284 101 72284 MGC 3310, RNF85 NM_004620 associated factor 6 (TRAF6), CGCTTTGACATGGGTAGCCTTCGG transcript variant 2, mRNA
KIAA1454, 2fp291, Homo sapiens S phase cyclin A-
CCAAGACTATCTTGAGCTGGCTAACAG
1 707359521 57 62902 98393456 90772705 91 772705 FLJ31533, 2NF291, NM_020843 associated protein in the ER ATTTCCTCAGCAGGCCTGGGAAG MSTP063, FLJ31953 (SCAPER), mRNA
FLJ25412, PDZK8,
Homo sapiens PDZ domain CCTCGTATGCACTCTGGCCTGCTTCTC
1 700776303 89585144 152 36429 14966846 15066846 DA129M162, NMJ 73791 containing 8 (PDZD8), mRNA CAGTTACTTGCTTGTGTAAGAAC FLJ34427
Homo sapiens ELMO/CED-12
MGC10084, CCCCTCTGTAGAGTCATGCGAACTACA
1 697950579 127 468445 21643512 15305594 15405594 NMJ 53702 domain containing 2 (ELMOD2), 9830169G11Rιk GTTTGGAACTTGGGACTTAGCCC mRNA
GCTGGGCACTATGCTAAGCA
Homo sapiens nuclear VCP-like CCATCAAGCCGGCAGAGAATCCCCCA
1 685436394 80 50197 13568095 10973095 11073095 NM_206840 CTTTGGGAGCAAGAACCTCC ILMNJ 690887 (NVL), transcript variant 2, mRNA CACGCTCTGAAGGACCCACTTTCA TACCTTCCAG
CCGCCTCATTTGCGCCTTGC
Homo sapiens transmembrane GAGAAAGATGGGTTGCTAGAGGATGG
1 670884956 18343929 30650595 29705594 29805594 MGC45714, C17orf32 NM 152464 AGCACTGCTGGACCAGGTTA ILMNJ 723398 protein 199 (TMEM199), mRNA TAGAACTGGAAGCAAGGCAGCTAC CAAGATGTTC
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequencβ_l
Homo sapiens eukarγotic translation elongation factor 1 beta 2 GTGTCCAGCCCACCGCCTGCCGACTT
1 667052451 61368477 10230447 10951 897 10952897 ™ Ctrlϋ D',iEF1 B' NM.001959 (EEF1B2), transcript variant 1, GTGTCATGCCCTACGTTGGTATAA mRNA
Homo sapiens SH3-domaιn kinase g protein 1 (SH3KBP1), CTΠTGCTTCAGGCTAAGAGCTGCCTC
1 660709729 18798977 3121 9644 2067 4644 20684644 GIG10, MIG18, CIN85 NM_031892 bindin transcript variant 1 , mRNA GCTCTTTGTCCCCCCATTAGGAT
Homo sapiens epithelial membrane GAGGGCAAGCCACCAAATTACCTAGG
1 658087645 5699873 9450889 6218006 6219006 CL-20, EMP-1. TMP NM_001423 protein 1 (EMP1), mRNA CTGAGGTTAGAGAGATTGGCCAGC
TCCCCCGGCGGAGCCAACC
Homo sapiens ancient ubiquitous TACGCAAGAAGGAGATTCACAGAGAG
1 65688212 234 19345 38803094 314 5976 315 5976 NM_181575 CTCACTGATGGGAGCCCTG ILMNJ658427 protein 1 (AUP1), mRNA ACGAGCCCAGGAGGCTGACTGAGC GGGTCATCTGTG GAATGGGTGTCATTGGACAG
Homo sapiens ubiquitin specific GGTGTGGGAGATGTGAGACCATTCTG
1 65582243 47 22109 78 18974 32 8719 338719 FLJ12552 NM_022832 GATGGTCTGC I I I I IAAAGT ILMNJ 734194 peptidase 46 (USP46), mRNA AGGTCAGCGATAGCCCAAAGGCTC GACTCTGGGC
Homo sapiens general transcription
CATTCCCTACTCTCTAAGGC
KIAA0011, TFIIIC- factor IHC, polypeptide 2, beta CCACAGACACCCTACCGATAGAACAG
1 639011209 7036393 11532727 10936434 10946434 NM_001521 CAAAATATCCTGAGCAAGGC ILMNJ 739374 BETA, TFIIIC110 11OkDa (GTF3C2), transcript TGGCTCAGATCTTACTTGCTCCTG TGGCAACCCC variant 1 , mRNA
Homo sapiens ER degradation CGCCTGGCAACCAAGTATCA
GGGGGGTAGAATTTAGTAAATATTCCA
1 633660764 33074347 54032263 36609763 36709763 C1orf22 NM_025191 enhancer, mannosidase alpha-like 3 TACCGTTCCACTGCCACCAA ILMNJ 766851 GCCGGTCGTTTTATGCACAAGGC
(EDEM3), mRNA AAGGAAGGGT
Homo sapiens ribosomal protein
ACCCGGCGCTCCATTAAATAGCCGTA
1 631528726 9667679 157 73096 17263928 17363928 NM_001035267 L41 (RPL41), transcript variant 2, GACGGAACTTCGCCTTTCTCTCGG mRNA
TNRC2, PACIP1,
Homo sapiens PAX interacting (with ACAGTCAGTGATGGTGGAGA
CAGF29, PAXIP1L, CCTTCACATGCTCTTGTTTTCCAGCTG
1 627355291 10633928 17305179 161 53513 162 53513 NM_007349 transcription-activation domain) TGGAAGCAGCAGTGAGGAA ILMNJ699317 CAGF28, PTIP, CTTTCCTGGGGGATCAGACTGTG protein 1 (PAXIP1), mRNA ATTAGGATTCC
FLJ41049
CCACCATGCCCAGCCTGAAT
Homo sapiens LEM domain TACCTGAAACTGTTAAGCCGACCAAGA
1 610462167 385 1726 6203059 40806427 40906427 MAN1 NM_014319 GATGAATTTATGTGAACACA ILMNJ 702244 containing 3 (LEMD3), mRNA TCCCTCCCTGCAAGACAGATGGG AAGCCCTCTG
Homo sapiens chromosome 3 open
CATATAAGCCCTGGGTCGGGGGGTAA
1 608048834 84295593 13555143 101490173 101590173 DKFZP434F2021 NM_001025072 reading frame 17 (C3orf17), CTGTGGGGATCACTGCCTGAGACA transcript variant 2, mRNA
Homo sapiens similar to C367G8 3 ηd10, C367G83, (novel protein similar to RPL23A CACAAGATGGCGCTGAAAGCAAAGAA
1 597832961 1842976 29447678 32328928 32428928 NM_001045548 RPL2B, RPL23AL (60S ribosomal protein L23A)) GGAAGCTCCTGCCTCTCCTGAAGC (LOC441743), mRNA
Homo sapiens ankyrin repeat AACAGAAGAGCAGGTGACGGGAGAGG
1 594984055 234 96428 37476428 355 78094 356 78094 NMJ 38797 domain 54 (ANKRD54), mRNA AGGTTGGAGGTGTAGCGATGGAGC
Homo sapiens chromosome 14 ACTCCAGCCCGCAGCACATT
TRM61, FLJ40452, TCTGACAGCCTCAAGGAAGGAGCAGT
1 594308848 118 35178 18868929 16488512 16588512 NMJ 52307 open reading frame 172 TCCGCTGTCCGTCAGTAATT ILMNJ 722056 GCD14, Gcd14p GCCTGTGTCAGCCATGGGGCCCTT (C14orf172), mRNA GTGTCCTCTC
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Gβnbank Description Probe Sβquβncβ Probe Id Probe_Sequence_l
MRTF-B,
GGGTGCGATCCTTTGCTGTA
DKFZP686J1745. Homo sapiens MKL/myocardiπ-like GGAGAAAGATACCAATCTACAGAGCC
1 584040743 7568573 11988928 8848572 8948572 AACTGGAGAGACCAGTCCCA 778734
FLJ31823, FLJ45623, ™m-u"tu*0 2 (MKL2), mRNA CTGCTTGTTGAAGCACTAGTTTAA AACAGAGGGG
NPD001
Homo sapiens alkB, alkylation alkB, hABH, ALKBH, AGTCAGTCCAAGGAGGTATGTTCTTCC
1 574749569 107 59761 16943929 1337768 1347768 NM 006020 repair homolog 1 (E coll) ABH ACAACAGCCTTCTCAGCCTCTGC (ALKBH1), mRNA
OEBT, MGC120398, Homo sapiens prickle homolog 4 GGCACCTCAGCCAGGGGTGTAGCCAA
1 557231407 16982476 26445645 29827642 29837642 NM 013397 OBTP, C6orf49 (Drosophila) (PRICKLE4), mRNA GTAGACAAATGGAATCCTGTGCTG
MGC10999, RP11- Homo sapiens chromosome 9 open GCCACAGTCACGCCACTGCATTCTATC
1548102347 8629766 13359761 107564285 108564285 NM 032307 575L7 5 reading frame 64 (C9orf64), mRNA CTGGGCAACAGATGGAGACCTTG
PMSCL2, PM-ScI,
Homo sapiens exosome component PM/Scl-100, PMSCL, CAGTTTGATCCAAATAAACAGACCCCG
1538701406 66548926 102398926 8743976 8753976 NM 002685 10 (EXOSC10), transcript variant 2, RRP6, p4, Rrp6p, p2, TCTGGCAAGAAATGCATTGCAGC mRNA P3
Homo sapiens serpin peptidase
PAI, PAI-1. PAI1, inhibitor, clade E (nexin, GGAGCAGAAATGCAAGGGGCTGCATG
1536818035 6375639 9798197 36477725 36487725 NM 000602 PLANH1 plasminogen activator inhibitor type ACCTACCAGGACAGAACTTTCCCC 1), member 1 (SERPINE1), mRNA
AD026, RP11- Homo sapiens adenosine A3 GCAGCGAGAGCTCACGGAA
CCTTCAGATTCCCCATCAACAAACACT
1528886574 85935165 13138512 13349344 13449344 552M11 7, A3AR, NM 000677 receptor (A0ORA3), transcript TTCCTCTCGTGCCAAAAGGA ILMNJ 795139 TGAGGGCCTGTATGCCTGGGCCA OA552M11 5 variant 2, mRNA AACCCAGTTGG
Homo sapiens zinc finger protein TTGTCCCTTTCGCTTCCACG
KIAA1339, P71, P51, CCAGACAAGATAGGAAAGGGGAAACC
1525588651 8911431 13595178 8668529 8768529 NM 170686 398 (ZNF398), transcript variant 1, TCCAAACCCCTTTAAGAAGG ILMN_1665416 2ER6 CCAGAAACGTGCTCTTCATCTGTC mRNA ATGAATGGGC
BRMS2, MRPS4, Homo sapiens IMP3, U3 small GTCAGAATCACAAAGACAGA
CTGGAAATCCCCACGCCCTGTTTCCCT
1525142048 20725977 31610059 3450331 3451331 C15orf12, FLJ10968, NM_018285 nucleolar ribonucleoprotein, GTGGTGGTTGGCAGGGGCT ILMNJl 717064 TTATCGTCTTGTGGTTGGACTGG
DKFZp586L0118 homolog (yeast) (IMP3), mRNA GCAGGAAGGGG
PMSCL2, PM-ScI,
Homo sapiens exosome component AGGAGAGAGGTTTGAGTTCT
PM/Scl-100, PMSCL, GACAGAGGCTTCAGGTACAACTGGCC
1509572477 7803518 11779976 10460559 10470559 NM 001001998 10 (EXOSCIO), transcript variant 1, GGGTATCCTCCCTTTCTGTA ILMN_1685472
RRP6, p4, Rrp6p, p2, ACAGAGATAGTCCTGGAAGACACG mRNA ACAGCCTCAA p3
Homo sapiens Sec61 gamma
GCTACGTGTCCCTGGCATTTTAGGTGT
150041281 7813531 11723522 9620764 9621764 SSS1 NM 001012456 subunit (SEC61G), transcript variant CGGTTGGGCAGTCATGGATCAGG 2, mRNA
GAGGCAGCATCCCGCGGCG
FLJ33201, FLJ12788, Homo sapiens tetratπcopeptide GCTGCCCTGTGGGTCTTGCTCAATAC
1495692183 3706518 554381 34540594 34640594 NM 022492 CTGACGGTCCTGGGGAGAG ILMN_1701937 MGC 120200 repeat domain 31 (TTC31), mRNA TGTTCATACCTGGAGAGAGAAGGT CATGGCGCCGAG
Homo sapiens zinc finger, DHHC-
GCCTACTCTGGTTAAGATGTTCTTTTC
1494423027 7386893 11039143 9420226 9430226 ZNF376, FLJ21952 NM_022494 type containing 6 (ZDHHC6), CTCAAAGGTGCCCTAGTGCCATG mRNA
IPOB, NTF97,
GGCTCGAAAGGCAAGAGCC MGC2157, Impnb, Homo sapiens karyopheπn TCAGAATTGGCAGCACAAAGAAAACG
1483318581 7551456 11201215 11606256 11607256 NM 002265 CAGCATCGGTTTTCAGAACA ILMNJ 805998 MGC2155, IMB1, (importin) beta 1 (KPNB1), mRNA CCCTCTCCTGACTTGTATTGTGGC CCTACATCTGG MGC2156
GATGCCTTCTGGATCTTAAG
Homo sapiens histone deacetylase AGGAACCAAATCAGAACAGCTCAGCAA
146030923 3156031 46087812 48090894 48100894 YAF1. RPD3 NM 001527 CCAGTTGTCAGTGGAGGTCC ILMNJ 739496 2 (HDAC2), mRNA CCCCTGAATTTGACAGTCTCACC TCAGGGCTGC
Fold change XS XS+ β GFs pOS +no GFs pOS +πo GFs Synonyms Genbank Description Probe Sequonce Probejd Probe_Sequence_l
GCTAAAGAATAAGACCTTGC
Homo sapiens SFRS protein kinase GGCAGCTGTAGATCTTGATCTTCCAG
1 458695475 484 38095 706 5643 851 9976 852 9976 SFRSK1 NM_003137 TTGAGAAGGCTGACCTGGAC ILMNJ 659985 1 (SRPK1), mRNA GTACCCCATGTACCTTTATTGAGC CCCTCCCTGG
Homo sapiens solute carrier family
AGCTCTCTCCAGATCATCCCTGTGAAT
1 449864221 16993094 24637679 217 87262 21887262 FLJ38932, PAT4 NMJ52313 36 (proton/ammo acid symportβr), GCCAAAGTAAACTTTATGTACAG member 4 (SLC36A4), mRNA
Homo sapiens nudix (nucleoside GATATGGTGCCCTGTGTATC
GCCGAAAACGCAAGGCCGAAGCCAAA
1 435618909 14162893 20332517 18446643 18456643 hYSAH1, YSA1H NM_014142 diphosphate linked moiety X)-type CCAGAGATGCTAGAAAACTG ILMNJ676448 GCCAGGGGATGGAGAGTTTGTGGA motif 5 (NUDT5), mRNA TTCTTTGCTC
CCGTTCAGTGTGGCCTGAAA
Homo sapiens kelch-like 18 AACAAGGAGATAGGGTAGACATTGTAC
1 425244024 8487268 12096428 94 90597 9590597 FLJ13703, KIAA0795 NM_025010 ACACCATGTGTGCCAAGTTC ILMNJ 814397 (Drosophila) (KLHL18), mRNA TCAGTGGGCCTTGGGGCCTAGCC CAGTTCACGC AAGATGCTGAGTGTCTGCAC
MGC42237, Homo sapiens RNA binding motif CCTGATAGTCTGTGTACAGCATTGTTT
1 424574845 24073096 34293927 311 48096 31248096 NM_152945 TGCTCCACTTGTCCCCCCGC ILMNJ697800 FU44612, DRB1 protein 45 (RBM45), mRNA. TGTCTGGGAAGCAGGGATTGCTG TCTCTCCTCA
Homo sapiens phenylalanyl-tRNA synthetase 2, mitochondrial ACATCCAAAGACGCACAAGACCAGCC
1 422574271 38691428 5504143 57420593 57520593 HS^C320 ^heRS^ ' 1^-006567 (FARS2), nuclear gene encoding ACTGCTACCGCATCACGTACCGCC mitochondrial protein, mRNA
Homo sapiens zinc finger protein 35 CTAGTCTCCATGGCCAAGCACTCAAG
1 415799115 1549226 219 33928 202 85596 20385596 Zfp105, HF 10, HF10 NM_003420 (ZNF35), mRNA GATTGATGGACACCACACACCAGC
Homo sapiens mitochondrial
TGGCATCGTCCCTGAAACGT ribosomal protein L13 (MRPL13), CTGCTACAGTTCAGCACCTGTTTTATG
1 405395262 741 2726 1041 781 11359727 1136 9727 NM_014078 GGATTGATGGCCCCAAAGAC ILMNJ695576 nuclear gene encoding TGCCGAATCACTGTGGGGAAAGG ACATCAGTGG mitochondrial protein, mRNA
Homo sapiens tuftelin interacting GCCCCAGGATTAAGATGGAT
GGCATTGGCGTGGCCGCTAGCTCTGT
1 391650292 23053094 32081845 331 38095 332 38095
Figure imgf000096_0001
NM_012143 protein 11 (TFIP11), transcript GCCTTAAGCGATGGCCCAG ILMNJ 746682 GCCCATGAACTTTAAGGACCTCAT variant 2, mRNA GGGTGCTTGGT
Homo sapiens signal recognition TGACACCCCTGCCCATTTTCTGTCTTT
1 389486973 5486298 7623 1396 70286978 70296978 ALURBP, MGC110981 NM_003133 particle 9kDa (SRP9), mRNA AATTAACCAAGGTGTTAGGTGTG
Homo sapiens mitochondrial ribosomal protein L47 (MRPL47),
CACCTGCTACCTTAGAGTGTGAAGGT
1 383296551 19301846 267 00177 270 74762 271 74762 MGC454°3' NMJ 77988 nuclear gene encoding GATGGTAACTGCCACAGCAAAGGC mitochondrial protein, transcript variant 2, mRNA
Homo sapiens cleavage stimulation rrArAfiτrτRTRr,rf5rτRAT
MGC75122,
1 38100461 428 2976 591 48096 6959976 6969976 MGC43001, NMJ301326
MGC117398, CSTF-77 (CSTF3), transcript variant 1 , CACTTAACCT TCAAGGGTGTCTTGTATGTGCCG mRNA
GPCR41, PAR1, Homo sapiens G protein-coupled AGGCCCGCACACCGGTACACTCGTGG
1 378241891 94236426 1298 8059 1112 56 1113 56 NM 024531 D15Ertd747e, GPCR receptor 172A (GPR172A), mRNA ACACCTACACACTCCATAGGAGAT
FEM1A,
AGACCATTTCTGCAGTTTGC
EUROIMAGE686608, Homo sapiens fem-1 homolog c (C GCCCTTATGTGTCACTAAACAACTAGT
1 3737574 404 1726 5552351 47735596 47835596 NM 020177 CCAAACCTCTACTGTTTGGG ILMNJ 773643 KIAA1785, elegans) (FEM1C), mRNA TTCTCTCCCTTTTGTCAGTTCCC ACAGTAAGCC EUROIMAGE783647
Fold change XS XS+ β GFs pOS +πo GFe pOS +no GFe Synonyms Gβnbank Description Probe_Sequence Probβ ld Probθ_Sβquenco_l
GATGCACAGAGGACACAGAA
Homo sapiens STARD3 N-terminal GAGTCTCCCTGTCGACAGTAAAGTTGA
1 368173048 344 85596 471 82263 441 62262 44262262 MGC3251, MENTHO NM_032016 GGACTTGGCAGCAGGGTGA like (STARD3NL), mRNA AATGGTGACGTCCACTGCTGGCT
TGACCTGATCA
Homo sapiens DPH2 homolog (S
CAAGTGTTCAGACAGCCACATGAGGG
1 361593065 647 68933 881 8893 81001843 811 01843 DPH2L2 NM 001384 cerevisiaθ) (DPH2), transcript GACAGTGCAGCTACAGGATATGCC variant 1 , mRNA
MGC997, DXS8237E,
Homo sapiens RNA binding motif KIAA0122, ZRANB5, GAGGTGGTGACTTTTGTTGGAAAATTG
1 360511622 1834 1184 2495 3394 2266306 2267 306 NM 152856 protein 10 (RBM10), transcript GPATC9, GPATCH9, GGCTGGGATCACGTCCTGTTTTG variant 2, mRNA MGC1132
TGCCACCAGACCAACACCCC
AAC-11, AAC11 , Homo sapiens apoptosis inhibitor 5 GACCAGCTAATCTGGACCTCAGAGATA
1 349210351 99398096 1341 0894 1257 6477 12586477 NM 006595 CAGACTTCCCCACCTTCAGC ILMNJ 784477 API5L1 (API5), mRNA GATCAGCCAGTGGCCCAAAGCCA CACCATCAGA
Homo sapiens blood vessel
TCACTGCTTCGGTTCTGCTCATCAGG
1 336476004 146 09761 19525595 8360916 8460916 POP^EtVE^42413 NM-147147 epicardial substance (BVES), GGACACGCTCCCTTACTCATGGCA transcript variant 5, mRNA Homo sapiens citrate synthase
GGCTGTTCAGCAGAGAAACC (CS), nuclear gene encoding CCTCAGGCAGAGGATGTTCTGGACCT
1 325465401 4680476 6203809 5894976 5904976 NM 004077 CATGTCCTCTCTCCATAGGG ILMNJ 683562 mitochondrial protein, transcript CCCCCTCTTGGTCCCTACTAGAGA CCTGTTTTAC variant 1 , mRNA
GGAGCTTGCCTCCTTTGAAT
Homo sapiens olfactomedin-like 3 AGAGCCCGAAGAGTCAAAACCCTCAA
1 303330702 349 9893 456 1518 34526013 34626013 OLF44, HNOEL-ISO NM_020190 GACCTAGAGCACAGGGAGG ILMNJ 813840 (OLFML3), mRNA TGTTCCCTCCTGCTCTCCTGCCCC AACTTGTCCAT
Homo sapiens thymosin beta 10 AAGAACACCCTGCCGACCAAAGAGAC
1 302543959 33132957 43157 133 40647 273 40648273 MIG12, TB10 NM_021103 (TMSB10), mRNA CATTGAGCAGGAGAAGCGGAGTGA
Homo sapiens eukaryotic translation ATGAAAGAGGACGCGAAAG
EIF-2B, EIF2Bβpsιlon, GAGGAGCTAAGCAGGCCCGGCAGTTG
1 276538656 191 88095 24494345 24331012 244 31012 CACH VvWM CLE NM 003907 initiation factor 2B, subunit 5 GGAAGAGCGAGGAGGAGCT ILMNJ693428 GAGGAAGGCCAGAGGAACAGCTTT epsilon, 82kDa (EIF2B5), mRNA GGCCGAGTGCTT
Homo sapiens ubiquitin-conjugating GATGTATGGTATCTCCCTTT
1 274209653 35000595 44598096 417 4726 4184726 UBE2G, UBC7, E217K NM_003342 enzyme E2G 1 (UBC7 homolog, GCCAAGCCATCCTGGATGAA ILMNJ 681783 yeast) (UBE2G1 ), mRNA ACCAAAGGAG
Homo sapiens stomatin (EPB72)-
1 266100965 2267 4976 28708809 31554727 31564727 HSPC108, SLP-2 NM 013442 like 2 (STOML2), mRNA
Homo sapiens cAMP responsive
MGC131709, BBF2H7, NMJ 94071
1 261682069 2544 1812 3209 9478 2657 3892 26583892 element binding protein 3-lιke 2 (CREB3L2), mRNA
Homo sapiens coiled-coil domain
1 25638015 1311 756 16480642 16806976 1681 6976 FLJ10294, HSPC128 NM.014167 containing 59 (CCDC59), mRNA
LBP-1B, LBP1A,
Homo sapiens upstream binding
1 253228219 1473 506 18466393 1602 5559 16035559 LBP1B, LBP-Ia, NMJ514517 protein 1 (LBP-Ia) (UBP1), mRNA
DKFZp686L1745
FLJ 10766, KIAA0483, Homo sapiens F-box protein 28
1 253200211 28923096 3624643 37337262 374 37262 NM 015176 Fbx28 (FBXO28), mRNA
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe Sβquence Probejd Probe_Sequence_l
DRP, DRP1, DMDL, Homo sapiens utrophin (UTRN), ACCGCACGACACCAGCACGGATCTCA
1249480053 4624128 57777557 50697205 51 697205 NM 007124
FLJ23678 mRNA CGGAGGTCATGGAGCAGATTCACA
Homo sapiens cleavage and
CPSF, CPSF73, CPSF AGCGTCACAGTGGACGGGAAAACTGC
1238598163 7660893 9488768 11209392 1121 9392 NM 016207 polyadenylatioπ specific factor 3, 73 CAACCTTAACTTGGAGACACGGAC
73kDa (CPSF3), mRNA
Homo sapiens zinc finger and BTB TTATTGGGCAGGGGGAGGG
TGGGGCTCCTGAAACACCTCGTTTTGA
1235616826 11489345 14196428 151 82678 152 82678 ZNF450, BIF1. PATZ2 NMJ314797 domain containing 24 (ZBTB24), GGAGGGCACAGGCAAGAAG ILMNJ693975 AGGTGAATCTTTGGTTTTCTCCC mRNA AGATTCACAGTG
Homo sapiens chaperoπin
CCTG, TRIC5, TCP-1- containing TCP1 , subunit 3 GCCAGGAACACTGTGGACGTCTTTGT
1195219843 47233093 5645393 611 381 612 381 gamma, PIG48, CCT- NM_001008800
(gamma) (CCT3), transcript variant TCAGAAGGGATCAGGTTGGGGGGC gamma
3, mRNA
Homo sapiens fasciculation and AGACTTCCCTACTGAGCCAC
AGTGTGTGTCCTCTGAGGTGCTTGAG
1 187472386 3265 5476 3877 7476 35489644 35499644 MGC117372, HUM3CL NM_005102 elongation protein zeta 2 (zygin II) CTTCTCTGCCACGAACCGGT ILMN_1777663 AAAGTGTACACTGCAGAACTGCCC
(FEZ2), transcript variant 1 , mRNA CGGGCTAGGA
FLJ26680, cC1qR, Homo sapiens calreticulin (CALR)1 CCCTCCAACCTGGGGGGCAGTGGTGT
1 183482704 1738856 2057 906 2062 0977 20630977 NM 004343 RO, SSA mRNA GGAGAAGCCACAGGCCTGAGATTT
SF3a66, SAP62, Homo sapiens splicing factor 3a, TTTTGTACTGCCCCCCGCTCATTAAAC
1 177628734 1999 3477 23544893 23497227 23507227 NM 007165 PRPF11. PRP11 subunit 2, 66kDa (SF3A2), mRNA AGCCTCCCCCAGCCCTGAGTGCA
FLJ20232, Homo sapiens Smith-Magenis CCCAAGGGTCTCAAGCCTGC
GGCAGCTTAGCCCTGAGGCCCAGAGA
1 175472196 24973096 293 5518 25181429 25281429 dJ1104E153, NM 019008 syndrome chromosome region, AAGTCCAGAAGGTGACAAAC ILMNJ 805979 CCTGCTGTCCTTTTTCTCCTTGAG HSU79252 candidate 7-lιke (SMCR7L), mRNA CCAGGAGCAC
Homo sapiens KDEL (Lys-Asp-Glu-
CAGCAGCCTTAATCTACATAATTCTTC
1 174074865 96558093 11336643 10903351 10913351 MGC33424 NM 153705 Leu) containing 2 (KDELC2), ATCTCGCCAATTCAGCCGCAGCC mRNA
Homo sapiens family with sequence GAAGGGCATGGGGTGCAGC
TTGGAGGTTGTGAATCAGTGCCTGTC
1 124498103 947 73926 1065731 96577673 96677673 CGI-128 NM 016062 similarity 96, member B (FAM96B), TAGAACAGTGTAGGTTCCCT ILMNJ673215 AGCCCGCTCCTGAGCCTGGCCTTT mRNA CAATAACCCCT
MGC142259, CSIG1 L12, PBK1, Homo sapiens πbosomal L1 domain CCTCAATGCTGCCTCCAGAGCTTTTTG
1 10832817 10669727 1182 5559 13543726 13553726 NM 015659 DKFZP564M182, containing 1 (RSL1D1), mRNA GAAATACTCAGATCCTGGCCGCC MGC138433
GGACAGAGTCCCCAAGGTTC
Homo sapiens xylosyltransferase I CCAGGTGTGCACTGGAAGTGAGGTCA
1 033414285 8584143 8870976 98898096 98998096 XT2, XT-II, xylT-ll NM_022167 CTGTTGTTGCCTCCTTCCTA ILMN_1681236 (XYLT2), mRNA CATGAGCAGCGTGGGAAGAAGACT AGCCTCATAT
ZNHIT5, Homo sapiens DEAD (Asp-Glu-Ala-
CTGGGATATTGCAAAACGAGTAAAGCC
0954120553 25256429 24097678 20074344 20174344 DKFZP564B1023, NM 001031725 Asp) box polypeptide 59 (DDX59),
CACAGGATCCATTCTTCCCCCTC RP11-92G122 transcript variant 1 , mRNA hsyπ16, SYN16, Homo sapiens syntaxin 16 (STX16), GTGCTGGCTGGGCCATGCTTGTGAAG
0893938756 1137 4727 101683093 74738513 74838513 NM_001001433 MGC90328 transcript variant 1 , mRNA TGATGTGTGTCTCTGATTTAACGG
Homo sapiens ribosomal protein
TCAAGGACTTCCTGCTCACAGCCCGA
0823093297 25317 39 20838574 24803848 24804848 NM 001035258 L38 (RPL38), transcript variant 2, CGAAAGGATGCCAAATCTGTCAAG mRNA
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens transmembrane BAX
CGI-119, ZPRO, S1R, GGAGTTGGTCTTAGCCGCTGCAGGAG
0807618512 3140 981 25367144 2924 3643 2925 3643 NM 016056 inhibitor motif containing 4
GAAP CCCTTCTTTTCTGTGGATTCATCA
(TMBIM4), mRNA
Homo sapiens leucine-zipper-like CTGGCTAAACAACCTGACAA
TCFL2, LZTR-1, GAGGGGCCTACCCAGAAGCCTCCTTG
0797878712 18568059 1481 5059 1359 1143 1360 1143 NM 006767 transcription regulator 1 (LZTR1 ), ACTGTGGCCAGGGGAACCG ILMNJ 735495 MGC21205 AACCAGTCTGCAACCCTGCTCTAT mRNA ACACAACCCTC TATTTAGGGCAATAAGCAGC
MGC87783, H33A, Homo sapiens H3 histone, family 3A TACAGGCCTGGTACTGTGGCGCTCCG
0795990745 10373098 825689 9004 189 9005 189 NM 002107 ATTGGCCTGGAGTGCCAGA ILMN_1675190 H3F3, MGC87782 (H3F3A), mRNA TGAAATTAGACGTTATCAGAAGTC GCGTCACCTCC
CLC-7, CLC7,
Homo sapiens chloride channel 7 CCTCACAGGGCCCCAAGGTGTCCGAG
079299651 16037976 1271 8059 1353 9476 1354 9476 FLJ39644, FLJ26686, NM_001287 (CLCN7), mRNA TGTGTTGGGTCTGAACGCGAAATA
OPTA2, FLJ46423
Homo sapiens spastic paraplegia 21 (autosomal recessive, Mast
BM-019, GL010, syndrome) (SPG21), mRNA CCCCGAAGTATCAGGTGTCCTCTCATA
0789297602 47345593 37369763 381 56427 382 56427 NM 016630 ACP33, MAST XM_945612 XM_945613 TTCCTGCCCCCTGTCAGTGGAAC XM_945615 XM_945617 XM 945619 XM 945622
Homo sapiens zinc finger protein TAAATTAACCTACCTGGCCAGGCACAG
0775008601 37068097 28728094 14664345 147 64345 MGC4400 NM_032679 577 (ZNF577), mRNA TGGCTCACACCTGTAATCTCAGC
NAG-2, NAG2, Homo sapiens tetraspanin 4
CCCTCACCTACATTCCATAGTGGGCC
0769703812 15370059 11830393 14085393 14095393 TETRASPAN, NM_001025235 (TSPAN4), transcript variant 3, CGTGGGGCTCCTGGTGCATCTTAA
TM4SF7, TSPAN-4 mRNA
L5, p15(PAF), Homo sapiens KIAA0101
TACTCGGGAGGCTGAGGCAGGAGAAT
0760310871 19342062 1470598 10281 739 10282739 OEATC1. OEATC-1, NM_001029989 (KIAA0101), transcript variant 2, GGCGTGAACCCGGGAAGTGGAGCT
NS5ATP9 mRNA
FLJ 36146,
Homo sapiens nbosome binding
DKFZp586A1420, GGTATGTCTGCCCATTTATT protein 1 homolog 18OkDa (dog) CTCACCCCTAGACGTTGCCAACCAGA
0750959019 58994644 4430256 4142 164 4143 164 MGC 157720, ES/130, NM_001042576 GCCGCTCTCTTTTCTGGAGG ILMN 1657141 (RRBP1), transcript variant 1, ACTGACGTGTGACCTCCTGGGTGT
MGC 157721, ES 130, AGCGAACCGG mRNA hES
PREDICTED Homo sapiens CDC- GTCTACACCCAGGTGCTAAG
GGGATATCAGTCGGTGACGATCAGGC
0743692001 24283928 18059763 16220178 16320178 XM_941392 like kinase 2, transcript variant 3 CTACACAGACTGGATTCAGA ILMN_1770765 CCTGGGCCCCCCTGCATCTTTTAT (CLK2), mRNA GAACCCTGGC Homo sapiens KH domain
T-STAR, SLM-2, GTCCCTGCTCCTCATGTTTC containing, RNA binding, signal GCACCCCAGCCCAAAGTGGTGCTGAT
0743498453 26156427 19447263 30269345 30369345 SLM2, EtIe, TSTAR, NM_006558 TGGTTTGGTGAGTCCTTTGT ILMNJ 731648 transduction associated 3 TACTATGATTACGGACATGGACTC etoile, SALP GCCACCACCC (KHDRBS3), mRNA
MGC 138220, Homo sapiens
FLJ11838, RP11- phosphopaπtothenoylcysteine AGAAAGGGAAAAGGCAGTGGTGTGTA
0741511578 11847726 8785226 9750143 9760143 NM_001077447 163G10 1, synthetase (PPCS), transcript GGCAAATATGGTTTGGCATTTGTC
MGC 117357 variant 2, mRNA
Homo sapiens ADP-nbosylation GGTCCTTGTCTAGCAGGAGACAACTG
0738420452 9613393 7098726 7380393 7390393 ARFL1 NM_001177 factor-like 1 (ARL1), mRNA CACAGGTATACTACCAGCGTTTGG
Homo sapiens WD repeat, sterile
FLJ36175, WDSAM1, CGTACAAGTCCCATGACAAATCTTGTT
0735434369 26543512 19521011 2002143 201 2143 NM 152528 alpha motif and U-box domain
UBOX6 CTTCCTTCAGCGGTACTTACACc containing 1 (WDSUB1), mRNA
Fold change XS XS+ 6 GFs pOS -mo GFs pOS +no GFs Synonyms Gβnbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens chromosome 1 open CTATGTTGACGCTAGCCTGC
STRF2, FLJ12666, CGGAAAGTCAACCTCACTCCTCAGCA
0729058698 431 44345 314 5476 478 35596 479 35596 reading frame 108 (C1orf108), ACAGACACTTGGGTCTATGA ILMNJ 680225
RP11-781D11 2 NM-024595 CTCACAGCACCTAGCTCTCCAGGT mRNA GAGCACAGTG GTAGTGAGCACAGGAGTCTT
Homo sapiens glutathione CCTGTGTGAGGGCACAACCAGGCCAC
0720670392 54845593 39525595 41904346 42004346 MGC14098, GSHS NMJ3OO178 GGGACGAGGCCTAGACTTG ILMN_1665414 synthetase (GSS)1 mRNA GGGACCTTCTATCCTCTGTATTTG ATCAGTGTCAG
Homo sapiens ubiquitin-conjugating
CCCCTGGATTGCCCCAGTCCTGTGAC
0718805088 1765 7976 12692643 10958976 10968976 NCE2, MGC18120 NM_080678 enzyme E2F (putative) (UBE2F), CATGTTGCCCTGAAGAAGACCATC mRNA
GCCCTTCTGCACAGGAGAG
Homo sapiens SREBF chaperone AATGCACTGAACCTGGACTTGGGGGA
0716882816 5122143 367 19763 39926428 40026428 KIAA0199 NM 012235 CAAGGCACTTGCAGTAGTGA ILMN_1712365 (SCAP), mRNA AAGAGCCGAGTATCTTCCAGCCGC TCTATGCCAGC
PSK1, TAO1, TAO2, Homo sapiens TAO kinase 2 ACCTGGAGTTTAATACAGTG
CTGTGTTCTCCTGGCGCTCCTCCCCT
0715837275 27730597 19850595 19562677 19662677 MAP3K17, KIAA0881, NMJ316151 (TAOK2), transcript variant 2, AGCTCTAGCAAGGGAGGCG ILMN_1665276 AAGTTATTGCTGTTCGCCCGCTGT
PSK mRNA CTGCCTTTTGT
DKFZp686D1664, CGATGACAAGGGAGACCATC
Homo sapiens heat shock factor GACCATCCGAAACCTGCGTCCCTGGT
0713232468 2130 1226 15192726 1440781 1441 781 NPC-A-13, NM_001537 CCCCACCCCCGGAGTCCAA ILMN_1800172 binding protein 1 (HSBP1), mRNA GATGTTCTCAAGCCTCGGAAGTGG
DKFZp686O24200 AATACAGAGTT TTGGGGCTGAATCTCCAGGC
FLJ12270, Homo sapiens WD repeat domain CTCTTGATGCCAGTGCAGAGACCAGA
0713215071 617 1726 440 1768 486 5976 487 5976 NM_030581 CTCACGAGGTCCCCTGTGG ILMNJ 774387 MGC11230, FP977 59 (WDR59), mRNA GTCAGATGCCCGAGGACAGTGGGT GGATGCTGCTA
KIAA0905, HSPC334,
MGC90305, ABP125, Homo sapiens SEC31 homolog A TGCAGCTCCAGGAAGTCCCC
CCCAGGCCAATAAGCTGGGTGTCTAA
0696526199 3212 331 2237 4727 1963606 1964606 SEC31L1, HSPC275, NM_014933 (S cβrevisiae) (SEC31A), transcript GCAATGTCTCACGTTGTCTT ILMNJ808919 AAGGACAGCTTCTCTTCCACTCAA
DKFZD686N07171 , variant 1 , mRNA TGACCAGTGG
ABP130
Homo sapiens shroom family CGAAAATGTTATTAAGAAAACAGTTCC
0695965815 1107 7976 77098926 460 1643 461 1643 KIAA1202 NM_020717 member 4 (SHROOM4), mRNA GGCCGGGCATGGTGGCTCACGCC
Homo sapiens twiπfiliπ, actin-
MSTP011, A6RP, ACCGGGCTGGCATTTTGTGACCCTTC
0695942333 1255 1892 873 5393 7530476 7540476 NM_007284 bindmg protein, homolog 2
PTK9L, A6r CCTGTTGCTGTCCCTGCATCTCGT (Drosophila) (TWF2), mRNA
CCTTCTGGAAGCTCAATTAT
Homo sapiens hypothetical protein TAAAAGTAGTACAAGCCTTAGCCAGGC
0695047898 6996726 486 30597 3159893 3169893 NM 197964 CACGAGCACATGGTGGAAAA ILMNJ 766219 HSPC268 (HSPC268), mRNA ACGGTGGCTCACGCCTGTAATCC CGTGGGCCGG
Homo sapiens postmeiotic
AACTTCGAAGGCTTAATGATGTCACCA
0694099559 13428928 9321013 11496428 11596428 MGC34222, PMS7 NMJ 74930 segregation increased 2-lιke 5 TTTCTACCTGCCACGTATCGGCG (PMS2L5), mRNA
CTTGGTCGCTGGCTGCGCT
Homo sapiens lactate CTGGTTAGTGTGAAATAGTTCTGCCAC
0689090901 41520 11 28611 13 27673639 27674639 LDH-M, PIG19, LDH1 NM_005566 CCACCCGATTCTCGGGATCA ILMNJ655171 dehydrogenase A (LDHA), mRNA CTCTGACGCACCACTGCCAATGC TTGGACCGTTT
Homo sapiens trafficking protein GCCAAACTTCCATTGGTCAG
ACAAGCTGGAGCAGGCCAACGATGAC
0688778796 12387227 85320593 984 5059 985 5059 MGC52424 NM 001042462 particle complex 5 (TRAPPC5), GTAATTCAGGAGGGTGGGG ILMNJ655504 GCGCGCACCTTCTACATCATCGAG transcript variant 3, mRNA AGGACCGGCTA Homo sapiens RAB34, member AACCATGCCATCATTCAGAC
GCTTGACCCCTGGACATTTGCACTGA
0688702581 1969981 1356731 1614 856 1615856 RAH, RAB39 NM_031934 RAS oncogene family (RAB34), GCTGCTCAACTCCATGGCAC ILMNJ 803881 CTTTATCCAGACCAAAGAGCTGCC mRNA CAGACGCGGC GCCATCCGAGTTACTCATGA
HSPA1 , HSP70-1, Homo sapiens heat shock 7OkDa GGAGCTTCAAGACTTTGCATTTCCTAG
0683115186 1852 0269 1265 1477 12749019 12759019 NM 005345 GACCAGTGCCCATGAAGGTC ILMNJ660111
HSPA1B, HSP72 protein 1A (HSPA1 A), mRNA TATTTCTGTTTGTCAGTTCTCAA AGACTGAGGC
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sβquence_l
Homo sapiens adaptor-related
TGACTTGAGTCCACAAGGAC
CLAPA1 , AP2-ALPHA, protein complex 2, alpha 1 subunit CAAAGCCAACCACCCCATGGACGCAG
0680743776 24186429 16464761 17304346 17404346 NM 130787 ACAAACACCTGAGTAGCTGG ILMN_1730347
ADTAA (AP2A1 ), transcript variant 2, AAGTTACTAAGGCCAAGCTTCTGG GCAGCCCTTG mRNA
NICE-4, FLJ42300, Homo sapiens ubiquttøn associated TGCTATGGGCCCTGCACTTCCTTTGCT
0679783151 94108093 63973096 87111426 87211426 NM 014847 KIAA0144 protein 2-lιke (UBAP2L), mRNA TCCTCCTGTTCACCCTGGTGGTG
MGC138220, Homo sapiens
FLJ11838, RP11- phosphopaπtothenoylcysteme AATATTGGTTGAATGCCTATGTATGTC
0678646611 84671844 5746226 65408093 65508093 NM 024664
163G10 1, synthetase (PPCS), transcript AGGCCCTGTGCTGAGCCATGAGG
MGC117357 variant 1, mRNA
D1S155E, FLJ26882,
Homo sapiens cold shock domain
UNR, containing E1 , RNA-binding GATGACAAGGGTCAGCTCAGGGGATG
067428617 11859762 79968735 92844215 93844215 DKFZp779B0247, NM_001007553 (CSDE1), transcript variant 1, TGGGGGAGGGCGGTTTTATCTTCC
DKFZp779J1455, RP5- mRNA
1000E10 3
AAGGAGACAGTGCCATCCAT
Homo sapiens WDR45-lιke GCCTGTGGTCTTCTCCGTACCCGCAA
0670159098 6181643 41426843 41220178 41320178 WIPI-3, WIPI3 NM 019613 GGAAACGGGAGACCTCTGT ILMN_1708529 (WDR45L), mRNA CGTGGTCATCTGTGCCCGTGACGT GCCGACACCGC
Homo sapiens chromosome 10 ATTCACATTGAAGAGGACTC
TCCTCACACCTTGCACCTTCCCTACTT
0668414993 23230595 15527678 25338095 25438095 FLJ11218 NM 001031709 open reading frame 59 (C10orf59), CTTAAAAGCCGATTTGCATG ILMNJI 770266 TTCTGAATTGCTATGACTACTCC transcript variant 1 , mRNA TGTGAAAGCC
MGC150640,
KIAA1610,
Homo sapiens mesoderm induction
MGC131940, ER1. MI- early response 1 homolog (Xenopus TTGCACTAC I 1 1 I I CAGTGGTTCTTGG
0666797486 291 16428 19414761 14834763 14934763 ER1, NM_020948 laevis) (MIER1 ), transcript variant 1 , TCCCCTTTACCACATCTTGGGTG
DKFZp781GO451, mRNA
RP5-944N151,
MGC150641, hMI-ER1
Homo sapiens small nuclear GTGAGGCACACATGATTGAT
TGGCCAGTTGCAGGTTAAGCCCCAGA
0659985386 9318513 61500824 10689761 10789761 SMD3 NM 004175 πboπucleoprotein D3 polypeptide GGGTATGGGGCCATGAAGA ILMNJ 705984 AAAGTTCACCTTGGAGAAGCTCCG
18kDa (SNRPD3), mRNA CCTTGAAGAGC
HGPS, EMD2, FPLD, LDP1 , LMNC, FPL, LFP, CDCD1, o sapiens lamm A/C (LMNA), ILMN 17
0659205502 36523477 24076477 32769644 32779644 NM 005572 Hom 37416 ACAGAACACCTGGGGCTGCGGGAACA LGMD1B, IDC, transcript variant 2, mRNA ILMNJ737416 CMT2B1. PRO1 , LMN1. CMD1A, CDDC
CFR-1. FLJ23319,
Homo sapiens golgi apparatus GGCAGTCCAGCCTGACCTTTCTGCAC
0656178854 2361789 1549756 10242393 10252393 MG160, FLJ23967, NM 012201 protein 1 (GLG1), mRNA ACTCCAGACAAACTTCCCAGACAA MG-160, ESL-1
Homo sapiens HLA-B associated TCTGGCTCGGAAGCATCTGCACAACTT
0655548829 3837143 25154346 30850177 30950177 D6S82E, NG26 NM 021160 transcript 5 (BAT5), mRNA TGAGGCCACTCACTGCACCCCAC
0655021957 22227261 14559344 17499762 17599762 VRF, VEGFL NM_003377 Homo sapiens vascular endothelial growth factor B (VEGFB), mRNA
Figure imgf000101_0001
AGGCAGCAAGAGGGGTCACATACC
Fold change XS XS+ 6 GFs pOS +no GFs pOS +πo GFs Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l
CDA1 , codanin, Homo sapiens congenital CCTGGGGATTGGGTGCCAT
AGGTCGCACCACTGCACTCCAGTCTG
0653797115 5355289 35012725 25282559 25292559 PRO1295, CDA-I, NMJ38477 dyserythropoietic anemia, type I CTCTCTAGGGGTAACACAAA ILMNJ 704368 GGTAACAGAGCGAGACTTTCTAGA
CDAI (CDAN1), mRNA GGGCAAGAGGT
Homo sapiens transmembrane GTCTATATTTGTAAACCAAGAGACCGG
0641932594 4376481 28094058 24829727 24839727 FLJ34583 NM_198276 protein 17 (TMEM17), mRNA CTGGGTGTGGTGGCTCACGCCTG
Homo sapiens PRKR interacting
FLJ13902, FLJ40957, GTGTAGATTGCCCCGGCCCCTCTCTG
0637953454 17338928 11061429 901103 911103 NM_024653 protein 1 (IL11 inducible) C114 AGCCCTGTAGCATCTGTGATAGCT
(PRKRIP1), mRNA
Homo sapiens hypothetical gene CCAGGGGCCTGTCAGTCTG
GAGGATCCCTTGAGCCCAGAGGTTCG
0637815401 11688095 7454847 42310047 43310047 NM_001013701 supported by AK096951 , BC066547 AATGGTTGTCCTGACCAGTA ILMNJ704599 AGACTAGCCTGGGCAACACAGTCA (LOC440157), mRNA ACCCAAGCCTA
Homo sapiens dexamethasone- CGCTCCTTCATTTCAGGTTACTCGTTC
0633892417 11847727 75101843 9719768 9729768 MYLE NM 014015 induced transcript (DEXI), mRNA TTCAGCAAGTTGGCAAAACAGAC
ATP6N1, VPP1,
Homo sapiens ATPase, H+
GCCCTGGTGTCCTGGGTTTTCGTGAT
0629083546 8142893 512256 58136426 58236426 transporting, lysosomal VO subunit GATCTTTGCTCTGTTTCCAGTGGG a1 (ATP6V0A1 ), mRNA Vph1
Homo sapiens CD46 molecule,
TLX, MCP, TRA2 10, ACTCAGGCAGATCTCAGCCCTCTACT
0628646639 14082727 8853059 8431101 8441101 NM 172358 complement regulatory protein MGC26544, MIC10 GAGTCCCTTAGCCAAGCAGTTTCT (CD46), transcript variant m, mRNA
Homo sapiens regulatory factor X, 5 GCAGAAAAACGCCTTAGCAG
GCTAGTTCTGTGGTCAGGCGGCACCA
0625982959 68313513 42763095 51396844 51496844 NM_001025603 (influences HLA class Il expression) CCTGTGTGAGGCTCGGAGT ILMN_1699859 ATGAGAAAGGAATGCAGACCCTCC (RFX5), transcript variant 2, mRNA AGTGGAGAAGA
Homo sapiens microtubule- GCCAAATGGCAACACCACGT
EBF3-S, RP3, EBF3, ACTCCCTCCAGCAGCCTGGTTCACCA
0624969577 16636429 10397262 19685596 19785596 NM 012326 associated protein, RP/EB family, CTAAAGCAGTTTCACAGCAT ILMNJ 720606 EB3 CACAAACTCTGCCTGGACCCCATT member 3 (MAPRE3), mRNA GGTCCCCTAC
Homo sapiens cholinergic receptor, TCCGCAGACGCTATTGCCAG
GCTTGATATAATAATTACTTAATGTGG
0623495322 11760809 73328094 530756 531756 NM_000745 nicotinic, alpha 5 (CHRNA5), GTGCTCAATGCTGTTCGCAT ILMNJ 786570 CCGGGCACGGTGGCTCACACCTG mRNA CATCCAGGCT
RP3-465N244,
Homo sapiens chromosome 1 open TGCAGATATGAGAGATAGCACAGATG
0618258746 20085596 124180954 843134 853134 NPD014, NM_020317 reading frame 63 (C1orf63), mRNA GACCAAAGGTTATGCACAGGTGGG
DJ465N24 2 1
FLJ23633, FLJ23807, Homo sapiens leukocyte-derived
ACTTAAATGGTCAATAGAAAAAGTAGG
0616715692 5876556 36241643 2863539 2864539 FLJ23701, L-RAP, NM_022350 arginine aminopeptidase (LRAP), CTGGGCGCGGTGGCTCACGCCTG
ERAP2 mRNA
TGGGTACCCCAAAAAGTGGA
Homo sapiens Josephm domain CCTGTGCGAGGTGCTGCTGGTAGTGA
0614935049 5517143 33926846 45596008 45696008 FLJ29018, SBBI54 NMJ 38334 ACTGCTGGATCACATGGTAC ILMNJ 739814 containing 2 (J0SD2), mRNA CCAAGGAGGTGGAGGAGAAGGGCA TTCTAACTTT
Homo sapiens iduronate 2-sulfatase
ATGTGCTCCCTTCCAGCTGGTGAGAG
0614405166 42403094 2605268 28241846 28341846 MPS2, SIDS NM 000202 (Hunter syndrome) (IDS), transcript GAGGAGTTAGAGCTGGTCGTTTTG variant 1 , mRNA
Homo sapiens FK5O6 binding
TTCTGTCTCATCAAAAACTGAAGTTAG
0614169196 17074518 10486643 6140393 6150393 FLJ20731. FKBP22 NM_017946 protein 14, 22 kDa (FKBP14), CTGGGTGTGGTGGCTCATGCCTG mRNA
Fold change XS XS+ 6 GFs pOS +no GFs pOS +πo GFs Synonyms Gβnbank Description Probe Sequence Probe Id Probe_Sequence_l
Homo sapiens zinc finger protein TGCCTTTGCCTCTCCATGACGCAATTC
0613405945 123 73928 7590241 73 33264 74 33264 HZF3, MGC126498 NM_003415 268 (ZNF268), mRNA CTGTGCGACATACGTAGCGGCCG
Homo sapiens family with sequence
TGCCGGGCAGGGCTGGAGCTGGACA
0609596043 78685596 47966428 601 9018 6029018 FU32495, CFBP NM_138401 similarity 125, member A (FAM125A), mRNA GAAGCCAGTGCCTTTAAGTCATTTG
ATCCCCGACTCGGAAAGCAA TST1, TPC, PTC, H4, Homo sapiens coilθd-coil domain AGAGGAGAGCCAAGCGCTAGCATGCC
0608990266 2008 3477 12230642 1361 0143 1362 0143 NM 005436 TCTGGATCAGAACTGTTTGT ILMNJ 676254
D10S170, FLJ32286 containing 6 (CCDC6), mRNA TTTTGCCTCTGCATATCTGTGCAC CTCGCTGCAG GTCTGCATTTTGGAGAGTCC
DKFZp686K23158, Homo sapiens actinin, alpha 4 AGGAGATGGCCCCAACAAGCACCCCG
0608267583 62600977 3807 8145 33396477 33406477 NM 004924 ACACCACGGACCAGGTTTTC ILMNJ692742 FSGS1. FSGS (ACTN4), mRNA CTΠTGCAGCAGAGGAGCTGAGTT CCCCAAGGCT
Homo sapiens alanyl-tRNA
NM 001605 AGATAACGGCTCTCCAGACCTGAGCT
0606244039 4381 331 2656 1558 2775 5728 2776 5728 synthetase (AARS), mRNA TTCCGCGTCAGCAAGTAGGAATCG
FιnGER3, dJ337H4 3, KLIP1 GGACTTCCCGGAGGAGGAC
Homo sapiens Yιp1 domain family, TGCAGCCAATGCAGAAAATGGGTCAG
0605624937 2001 3309 12120559 10969727 1097 9727 TACGGGTTGGACGAGATATG ILMN_1790953
DKFZP566C243. RP3- NM-015388 member 3 (YIPF3), mRNA CTCCTTTGAGAACCCCTCCCCACC ACACCTAAGGA 337H43, C6orf109
TCACGGTGGGGGAGGAATG
MGC138210, SKRP1, Homo sapiens dual specificity CTGAATTAAAAAATCTGTTGGTGGCCG
0602429387 25196895 1517 935 1158231 1159231 NM 080876 TGAGCTGGAGACAATGACAG ILMNJ 772328 DUSP17 TS-DSP1 phosphatase 19 (DUSP19), mRNA GGCGCAGTGGCTCATGCCTGTGG GGGAGAAAGTC
Homo sapiens ATP-bindiπg
TAPL, KIAA1520, cassette, sub-family B (MDR/TAP), AGCCCAGGATCTGGCTTTGCCAGAGG
05993542 153 71011 92 1268 161 57262 162 57262 NM 019624 EST122234 member 9 (ABCB9), transcript TTGCAACATGTTGAGAGAACCCGG variant 2, mRNA
Homo sapiens transmembrane and
MGC5442, C7orf21, TTAGTGTTCTGCCGGAGGACCCAGCC
0 593829582 91703094 544 5601 6154435 6164435 NM 031434 ubiquitin-like domain containing 1 SB144 GCCTCCAATCCCTGACAGCTCCTT (TMUB1), mRNA
SAC3, RP1-249I4 1,
Homo sapiens FIG4 homolog (S GATCTTCCAAGCCCACATCCAGGCCA
0 586090963 178 31012 104 50595 124 91429 125 91429 hSac3, dJ249l4 1 , NM_014845 cerevisiae) (FIG4), mRNA GCCAAGGTATCATGCAGCCCCTAG
KIAA0274
Homo sapiens solute carrier family
0 580051095 392 88513 227 89345 321 34763 322 34763 GLUTX1, GLUTS GGATCTTTGTCTTCTGGCTGGAGGTG
NM 014580 2, (facilitated glucose transporter) CTTTTGGAGGTTGGGTGCTGGGCA member 8 (SLC2A8), mRNA
C20orf81, bA12M19 1, Homo sapiens family with sequence CCATCCTTGCCCTGGCAGCT
CACTCAGAGAGACTGATCCACACATAC
0575832958 20600179 11862262 107 99762 10899762 FLJ22376, NM_022760 similarity 113, member A GTGGTGGTCATTATAAGCAT ILMNJ 750312 AAACTGGACAGACGGCCTCCTGC
DKFZp547L054 (FAM113A), mRNA GGTCCTCCTG
MGC141937, FBH1,
Homo sapiens F-box protein, Fbx18, MGC131916, CTTGCCTCCCCTCTGGATGTATCTGGT
0574010549 73039764 41925595 482 72263 48372263 NM 178150 helicase, 18 (FBX018), transcript FLJ14590, CAGGGAAGTGGGGGATGTTCTTT variant 2, mRNA MGC141935
GCCTCTTCCCAGATGGCAAT
Homo sapiens chondroitin CCCCCTGACGCTGCTGATTCGGGCTG
057042723 751 82263 4288601 429 18927 430 18927 FLJ22678, CSS2 NM 024536 « - ,.„„„ -,.,. CTGTCCTATCTCTGTGCTGG ILMN 1767113 polymerizing factor (CHPF), mRNA MGfijGCTAG TGGCCTCCACGTATTTATGCAGTA
Homo sapiens family with sequence CCTACTGGGAGGTGGGACC
GTGCCTGGTGCCAGGTACACGGTCCT
0563404601 34344345 19349762 27541428 27641428 FAM108A2, C1orf47 NM_001080422 similarity 108, member A3 CCTTTCATTTTCAGTTTTGCT ILMNJ 746171 CTTCTCGCACGGCAATGCCGTGGA
(FAM108A3), mRNA CATCTAGGGA
Fold change XS XS+ 6 GFs pOS +no GFe pOS +no GFs Synonyms Genbank Description Probe Sβquence Probe Id Probe__Sequence_l
Homo sapiens endoplasmic
ERGIC32, MGC14345, reticulum-golgi intermediate CTGCGAGTTGGTTGGGCTTGACATTC
0561836648 16486429 926268 16473929 16573929 NM 020462 KIAA1181, ERGIC-32 compartment (ERGIC) 1 (ERGIC1), AGGATGAGATGGGCAGGCACGAAG transcript variant 2, mRNA
CSIF, IL-10, IL10A, GCTCAGCGGCTATGACCAG
Homo sapiens interleukin 10 (IL10), GGAAGTTGCAGTGAGCTGATATCATG
0557679737 1056531 58920593 4310101 4320101 MGC126451. TGIF, NM_O0O572 GTGCTCCACGAAGACGAAAC ILMNJ 800381 mRNA CCCCTGTACTCCAGCCTGGGTGAC MGC126450 CACGAACCGCA
Homo sapiens cytochrome b5
GGGCCCTCCCAGAACCTCAGCATTTC
0556429571 25001475 1391156 12542101 12552101 DIA1. B5R NM 000398 reductase 3 (CYB5R3), transcript CTTCCAGCCCATCCAAACACTGAG variant M, mRNA
Homo sapiens signal recognition
CCCCGTATGCAACCCTTGCC particle 14kθa (homologous AIu AGCAGTTCCTGACGGAGCTGACCAGA
0555538632 68510645 3806031 39565435 39575435 ALURBP, MGC14326 NM_003134 TCAGAATTCCTTCAGAGAGA ILMNJ 744817
RNA binding protein) (SRP14), CTTTTCCAGAAGTGCCGGACGTCG GGTGACTGTC mRNA
Homo sapiens zinc finger protein 32
CTGTACCCAGTGCAGGAAGAGTTTCC
0551728253 33763928 18628513 27676428 27776428 KOX30 NM 001005368 (ZNF32), transcript variant 2, ACACCAGGGGGAATTGTATTCTGC mRNA
Homo sapiens RAB22A, member
GCCTGGTTACCTGTCATGGAATGCTG
055133506 5381893 29672263 32787262 32887262 MGC 16770 NM 020673 RAS oncogene family (RAB22A), CAGTGGTGGTTTGCCAAGCTTCTG mRNA
Homo sapiens DMC 1 dosage
MGC 150473, suppressor of mck1 homolog, GCCAGGACAGCCCTCCCAG MGC150472, DMC1H, CAAGTGCAGTGGCATGTGCTTGTAATC
0550581367 2773806 15272059 96783514 96883514 meiosis-specific homologous CCATGAATCCTTACTCAGCT ILMNJ 758529 Hsϋm15, dJ199H16 1, NM-007068 CCAGCTACTCTGGAGGCTGAGGC recombination (yeast) (DMC1), ACCTCGGGTTG LIM15 mRNA
Homo sapiens hydroxysteroid (17-
TGCAGCAAGAAGATTGGTCTTTACCTA
0545161734 32039226 1746656 20320977 20330977 KAR NM 016142 beta) dehydrogenase 12 GGCTGTGTTTCCTAAGCTCTGAG
(HSD17B12), mRNA
Homo sapiens macrophage
EMLP, HLC-10, EMP, TCCGCCCATGATGCTGCCCAACGGCT
0539813908 7841393 4232893 567631 568631 NM 005882 βrythroblast attacher (MAEA), PIG5 ACGTCTACGGCTACAATTCTCTGC transcript variant 2, mRNA
MGC125857, AMP,
Homo sapiens adenine CTCAGGGATGTGACTGAGG MGC 125856, TCCCTGGAGTACGGGAAGGCTGAGCT
0538308076 6085226 32757263 518 3976 519 3976 NM 000485 phosphoribosyltransferase (APRT), CCCAGGAGGGACCTGTGAG ILMNJ 760628 DKFZp686D13177, GGAGATTCAGAAAGACGCCCTGGA transcript variant 1 , mRNA GGTCTGTTTACA MGC129961
SEC15L1, SEC15L3,
EXOC6A, Sec15p, Homo sapiens exocyst complex CGGAGCCCCTACGGCTTTA
GTGCGAGGGTAGATGGTTCCTGCACA
0533381597 14926428 7961482 133 55595 134 55595 DKFZp76112124, NMJ319053 component 6 (EXOC6), transcript GGCATGGAGCCAGCGTCAA ILMNJ 676822 CAGAAGTTACCACAGGGGTCAGGT
FLJ1125, FLJ11251 , variant 1 , mRNA CTACGATGACTA
SEC15L, MGC33397
MGC138424, Homo sapiens catalase (CAT), ACATTTAATACAGCAGTGTCATCAGAA
053099092 4998393 26541013 311 9643 3129643 NM 001752 MGC138422 mRNA GATAACTTGAGCACCGTCATGGC
Homo sapiens melanoma antigen TACAATAGGACTGTTTACTG
CAGCCAGTGCCAACTTCGCTGCCAAC
0529289963 15775848 8349998 9824 389 9825 389 NRAGE, DLXIN-1 NM 001005332 family D, 1 (MAGED1), transcript CCCACCTCCGCCTGCCAGC ILMNJ716957 TTTGGTGCCATTGGTTTCTTCTGG variant 3, mRNA CCACCCCAGCC
O-Fuc-T, O-FUT, Homo sapiens protein O-
AATAATAGCCAGGCGTGGTGGCACAT
0528694471 36343726 19214727 1301 1892 1302 1892 FUT12, O-FucT-1, NM 015352 fucosyltransferase 1 (POFUT1 ), GCCTGTATTCCCAGCTGCTTGGGA MGC2482, KIAA0180 transcript variant 1 , mRNA
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probθ Sβqueπce Probe Id Probe_Sequence_l
Homo sapiens phosphodiesterase
DKFZp686F2182, 4B, cAMP-specific GGTGCTTTGGCCCTAATAGC
TTCTTCTGAATGCTCCCGAACTACTGA
0526894405 11009762 5800982 14135178 14235178 MGC126529, DPDE4, NM_002600 (phosphodiesterase E4 dunce ACTGGACAACACCACGACCA ILMNJ 670807 CTTTGAAGAGGTAGCCTCCTGCC
PDE4B5, PDEIVB homolog, Drosophila) (PDE4B), CATGGAAACA transcript variant a, mRNA
MGC125648, Homo sapiens chromosome 10
GCAGTCCCCTGTGTTTGCCAGAGATA
0524752801 30715594 16118094 14458511 14558511 FLJ20367, FLJ20154, NM 001083913 open reading frame 26 (C10orf26), CTGTGCTCGAAGTAGAGGTTTTAC OPAL1 transcript variant 1 , mRNA
Homo sapiens LYR motif containing ATGTATGGAGTCATTACTTCTGACCTT
0516537309 81198096 41941846 55955597 56055597 NM_001001660 5 (LYRM5), mRNA GAAATAGCCTGCTGGTGACTGGC
Homo sapiens ferritin, heavy GTGCCACCTCCTGTCTACTC
GGCCGCCATAAACCGCCAGATCAACC
0512576384 35501062 18197006 1962304 1962404 NR_002202 polypeptidθ-likβ 7 (FTHL7) on ATTGTTGCATGAGCCCTGTC ILMNJ 796490 TGGAGCTCTACGCCTCCTACGTTT chromosome 13 TGCCAGCCCA
Homo sapiens transcription factor
CTGCTCGGCCCCCAGCCCA
TFAP2, AP-2, AP2TF, AP-2 alpha (activating enhancer GGTGCGAGACCGAGAGGGGCATATCC
0495481585 20774762 10293512 109180954 110180954 NM_003220 CCCAGCCAAAAATACAGCTG ILMNJ 659660 AP-2alpha binding protein 2 alpha) (TFAP2A), GTTCACGCCGATCCATGAAAATGC GGCTGAAACCT transcript variant 1 , mRNA
Homo sapiens rettnoic acid AGCTACTTTTCCAGTAGTTT
CCTGGAGCCCGTGGGTGCACCTGTTA
049209589 991 19763 48776428 50857678 50957678 NR1B1. RAR NM_000964 receptor, alpha (RARA), transcript GCCACTTTCTCCGAGGTAGT ILMNJ 751615 CTGTTGGGCTTTCCACTGAGATCT variant 1 , mRNA TTGGCTGCTC
Homo sapiens sirtuin (silent mating
TCTTCGGGTCCTTTTTCCTC type information regulation 2 GGCCACACGCAGAGGAGAAATGGTCT
0487674688 21696011 105805954 16873929 16973929 SIR2L5 NM_012241 homolog) 5 (S cerev,s,ae) (SIRT5). I^^^f^∞∞ ILMN-170193° TATGGGTGGTGAGCTGAGTACTGA transcript variant 1 , mRNA ACAATTTGCGC
Homo sapiens chromosome 19
CAGCCTGACTCCTGCCTGATAGCTCC
0486387667 16435059 799381 8406476 8416476 MGC16353 NM_138774 open reading frame 22 (C19orf22), TGTGTCCCCATGCTGGTCCTCCTG mRNA
Homo sapiens cyclin G1 (CCNG1), GCTGCTGAAGTAGTGTTTAGGATCCTC
0484681646 16402643 795006 10965977 10975977 CCNG NMJ 99246 transcript variant 2, mRNA CATGGCAGTTAGTGAATGTAAGA
Homo sapiens aryl hydrocarbon TAGGAATCTATGATGCTGAT
ARA9, FKBP16, XAP2, TTCTCCCATTGACAGGAGCACTTGGC
048418884 6549393 3171143 26478094 26578094 NM_003977 receptor interacting protein (AIP), GGTGATGGAGATTTTGATGT ILMNJ693771 SMTPHN, FKBP37 CCTGCCTTACCTGCCAAGCCCACT mRNA GGATGATGCC
MGC 133309,
Homo sapiens iπterleukin 17 FLJ35755, ATTAATCAGGCGTGGTTGTGTGTGCCT
0484066151 8447143 4088976 32402264 32502264 NMJ301080973 receptor D (IL17RD), transcript
DKFZp434N1928, IL- GTAATCCCAGCTACTCGAGAGGC variant 1 , mRNA 17RD, SEF, IL17RLM
Homo sapiens protθasome bβta2ι, MGC1665, ACCCTGGAGCTAGTGGAGGAAACTGT
0483801807 15470559 74846844 100997266 101097266 NM_002801 (prosomθ, macropain) subuntt, beta LMP10, MECL1 GCAGGCTATGGAGGTGGAGTAAGC type, 10 (PSMBIO), mRNA
Homo sapiens double homeobox A GAATTGGGCAGCTCATGCTT
TGTGGTGGCATGTGCCTGTAATCCCA
0483740768 19251309 9312643 6419309 6429309 NR 002220 pseudogene 3 (DUXAP3) on GAGACCCAATCTCCATGATG ILMNJ792922 GCTACTCTGGAAGCTGAGGTAGGG chromosome 10 ACCTACAAGC
FLJ34709, AXLLG, GATTGCAGGGTCCGCCTTCT
Homo sapiens growth arrest-specific GCTGAGAGCTGGGCTTTCCTCTGTGA
047954595 3787206 18161393 21382559 21392559 AXSF, NM_000820 CAAACCCCACTTCCTGGACC ILMNJ 705433 6 (GAS6), mRNA CCATCCCGGCCTGTAACATATCTG
DKFZp666G247 ACATCATCCA
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probβ Sβquencθ Probejd Probe_Sequence_l
PRDX6, AOEB166,
MGC 142285, B 166, Homo sapiens peroxiredoxin 5
TCCCACTCCGCCACCTCCGT
PRXV, PLP, MM -„„ . (PRDX5), nuclear gene encoding GGCCAAGGGAGTCCAGGTGGTGGCC
047589945 3110456 14802643 15918477 15928477 CCACACCTCGGTCTGATGG ILMNJ715110
MGC117264, SBBHO. NM-012094 mitochondrial protein, transcript TGTCTGAGTGTTAATGATGCCTTTG GCGAGAAATAT
ACR1. PMP20, variant 1 , mRNA
MGC142283
Homo sapiens snurportiπ 1
^π. Snuφortml, NM_∞1042588 CCCAAGTTGAAGGGTTCTTCCCATAGC
0474428932 62673096 2973393 4212726 4222726 (SNUPN), transcript variant 3, KPNBL CCAGACCACCCTGGATGCCTCAT mRNA
Homo sapiens
GAGTGGGGCTTCATGACCAT glycerophosphodiester GCTTACCGCTTCTCACCTTTCAACCCC
047056792 41250177 1941101 27118097 27218097 GDE1. 363E62 NM 016641 GTGCATCAGAATTGCCTGGA ILMNJ 797903 phosphodiesterase 1 (GDEI)1 ATCTGTGGCCTTTGTCCAGGCCC GTGTGCACTG mRNA
AAACAACCCTGAGCCCAGG
Homo sapiens modulator of GTGCAGTGCTCTGAGGGGACAGACAA
0465124943 36622263 17033928 23443929 23543929 MAP-1. PNMA4 NM_022151 GCCAACCCCTACGGAACACC ILMNJ 662383 apoptosis 1 (M0AP1), mRNA GGCTTGGGTGTATATGCCAACCAG ACTACTTTACC
FLJ39091. PGR-2, Homo sapiens zinc binding alcohol ACGATTGCCAGCCGCCCGC
ACAGCCGGGCCTGATGTCTCAAGCCT
0462923758 20198096 93501785 7296098 7396098 PGR2, NM_152444 dehydrogenase, domain containing GTACACCTACAACAACATCA ILMNJ673488 GTAATCCTAGCACTTTGGGAGGCA
DKFZp686P10120 1 (ZADH1), mRNA CCTGTGCCAGC
Homo sapiens zinc finger, AN1-type TTTACCACTGCTGTCAAGCCACAGCCC
0453864618 46758093 21221844 20784761 20884761 FLJ13222, TEX27 NM_021943 domain 3 (ZFAND3), mRNA TTGGCCACCATACGGGCCATCCT
Homo sapiens solute carrier family CCGTGTGAGCCAGTCCAGG τrτr-rrτrrΔP4rΛΔΛr-f-τrτΔrΔr
MLVAR, PIT-2,
0452037606 54923926 2482768 23739761 23839761 NM_006749 20 (phosphate transporter), member AGGGTGTAAGTTCTGAATGG ILMNJ687501 c^CCAGGCTCTAC^CCrAπ GLVR2, Glvr-2 2 (SLC20A2), mRNA TTCCTTGCTGA CCCCAGGCTCTACTCCATCCCATT
Homo sapiens lipoma HMGIC fusion TCCCCACACACGCCTATGCACAAACGT
0450345985 13027893 58670593 73145593 73245593 NM_005780 partner (LHFP), mRNA GGATTATCGCACAGACTGGGAGG
Homo sapiens cysteine and glyc,ne- ™^°∞^^TCAGC GAGCTGGAAAGCCCTGGCACAAAAAC
0443868574 7596226 3371726 26813095 26913095 CRP2, LMO5, SmLIM NM_001321 rich protein 2 (CSRP2), mRNA GCTCCCAGTGcf ILMNJ798138 TGTπccGAjGjGCMAGjGjGGG FLJ10420, RP4- Homo sapiens NECAP endocytosis TGTTGTCATGGAGCTGTGGGAGTTGG
0438254685 12197476 5345601 6024643 6034643 NM 018090
798A10 1 associated 2 (NECAP2), mRNA CACTCTGTCTGCTGGTGGCCCTCT
PAST1. PAST, TGGACGCGTCCAGCCAGAC
Homo sapiens EH-domain CACTCCATACAGTATTAGGTGAGGATG
0437917295 2858706 12518768 22072644 22082644 HPAST1. FLJ42622, NM_006795 CCAAGGGGCTGGGGGCCCT ILMNJ 768427 containing 1 (EHD1), mRNA GATGCGGGCGCTGTCCTTGCCGG FLJ44618, H-PAST GCTGGAGTGATT
Homo sapiens phosphatidyl inositol- TGTCCAGAGGGGGTTCTGC
PIP5Kgamma, PIP5K- TGGTGCGTGACAATCCAAAGCGCCGA
0434473309 10767101 4678018 50581012 50681012 4-phosphate 5-kιnase, type I, CCCTTGTGAAGGCCCATTCC ILMNJ745365 GAMMA, KIAA0589 - GACGAGGGTGCTGTGTCCCTCAAA gamma (PIP5K1C), mRNA TGGCACTTAGA
Homo sapiens carboxymethylenebutenolidase GGACCAGCTGACAGGTCAAGTGTGGC
0431694425 5204726 22468512 543631 544631 FLJ23617 NM 138809 homolog (Pseudomonas) (CMBL), CTTTTCTGGTCTTTGAACACATCA mRNA
Homo sapiens brain and GTACGTTGGTGCCCGCTGCT
CCTGCCTCTG I I I I I
0429060045 7122976 30561844 50885178 50985178 BRCC45, BRCC4 NMJ99191 7 (T5NHF£RS£F1A1 m "ToduIlTator™) (BRE), G rTrCrTrArArTrGrCrCrCTGGAGCCTC ILMN 1693060 GCCAACTCTCACATTTCAGTCCG transcript variant 3, mRNA CCTGGCCCCC
Fold change XS XS+ β GFs pOS +no GFs pOS +πo GFs Synonyms Genbank Description Probβ Sequence Probejd Probe_Sequence_l
GGTGAGCCCACCAGTGAGG
Homo sapiens somatostatin TGTAAATTAGTCGGGCGTGGTGTCAC
041871783 32332263 135 38095 41 610107 42610107 NM_001050 ATTACTGATGTGGACAGTTG ILMNJ 787680 receptor 2 (SSTR2), mRNA GTGCCTGTAATCCTAGCTGCTCGG ATGGGGTTTGT
Homo sapiens S-phase kinase- CCCATCTTCCTGCTATAAAT
FBL1. MGC1366, AGTGACAAGAGCTGGGGTTAGGATCC
0417857496 2284206 9544726 1457656 1458656 NM_032637 associated protein 2 (p45) (SKP2), GTGGGTGTGATGGCTGGAT ILMN_1764577 FBXL1. FLB1 GGTTGGACTCTGACATCGGATGCC transcript variant 2, mRNA CTGGGGCAGCC
HUS, MGC88246, HF1 , FH, ARMD4, Homo sapiens complement factor H GGATCACATTCATTGCACACAAGATGG
0417701378 183 51012 7665243 18224762 18324762 NM_001014975 ARMS1. HF, CFHL3, (CFH), transcript variant 2, mRNA ATGGTCGCCAGCAGTACCATGCC FHL1. HF2
GCTGTGGAACAATCAGCCCA
PWDMP, KIAA1638, Homo sapiens WD repeat domain ACCTCTCCAGGTCGGCACTTTCCACTT
0401038578 26501428 10628095 118 180954 119 180954 NM 025132 TCTCTTTGTGACCTGGAGCA ILMN_1680367 FLJ23127, ORF26 19 (WDR19), mRNA CTGTACGGTGGCAAAACGATGAC GTCAGAGGGC with sequence CAGTTCTCACTCTCTTAAATG
ACCAGAGACGGCTTTGTTCTCCCAGC
0 397927384 9629762 38 31946 59494514 60494514 FLJ00001, C9orf28 NM_033446 GTACCTCAAAAAGCTGGAGC ILMN 1661833 TAAGGCCGTGGAGCTGCTGTGTGA
Figure imgf000107_0001
CTCTCTGCC
Homo sapiens microtubule- TATCAATTCTGCTGTGTTCC
CCCTCTTTAACACAAGGGCCCTCCTTG
0377937991 12152393 4592851 651 85596 652 85596 RP1 , EB1, EB2 NM 014268 associated protein, RP/EB family, CTGGCCTGCAGGGAGGTCC ILMNJ 743784 TCATTGACCTTAGCTAAACCATG member 2 (MAPRE2), mRNA CCACAACCACG
MGC125831, Homo sapiens family with sequence GAATAGTCTCACTGTCCCCC
AGAGACACCCCCTCCCAAACACATAAA
0377634922 3734143 141 01428 16247263 16347263 DKFZp686J07229, NM_001002034 similarity 109, member B GTTTGCCTCCACGAGCCTGC ILMNJ 709247 ACTTGCCCCTTCCTAGCCTCGGC
MGC125832 (FAM109B), mRNA TGTTTCCAGG
Homo sapiens poly (ADP-nbose)
ADPRT3, ADPRTL3, TGAGGTCAACGGCAGAGACT polymerase family, member 3 CTGTGCCTGGCTTATTTCACTCAGCAT
0377383484 2100885 7928393 922 5476 9235476 pADPRT-3, ADPRTL2, NM_005485 TATCCAGAGCAACTCATGAC ILMNJ 742949
(PARP3), transcript variant 2, AATGTGCACCGGGTTCACCCATG
IRT1 , hPARP-3 CAGGCTGTGG mRNA
RNF49, MALT2, API2, Homo sapiens baculoviral IAP
GTGGTGGTATGTGCCTGTAGTCCCAG
0 364462925 10320143 376 13095 242 88095 24388095 HIAP1, AIP1. MIHC, NMJ82962 repeat-containing 3 (BIRC3), GCTGAGGCAAGAGAATTACTTGAG
HAIP1. CIAP2 transcript variant 2, mRNA
Homo sapiens CDC42 effector
UB1 , CEP3, CCATGACTCTCCAGTG I I I I I I CTGTT
0360290889 56090594 202 0893 311 45593 31245593 NM 006449 protein (Rho GTPase binding) 3 FLJ46903, BORG2 GGACCACACCCGTCACAGTTCAC
(CDC42EP3), mRNA
Homo sapiens chromosome 16 GGAGATGGTGTGTCCTGAAC
CTCACCTTGGCTGTGGGCTGTGAACA
0 35363462 3282393 11607678 9850185 9950185 ATP-BL NM 004913 open reading frame 7 (C16orf7), AGTGTAGCTCAGGTCAGCTT ILMNJ 788786 TTCCGGGACCCTGGGCATCTTATC mRNA GAACTTTCCA
Homo sapiens annexin A11 AAGCGGGGAGAGGGTACAC
GCCAAAACTTGTTTCCACATTAAGAGT
0350496348 49426846 17323929 2254226 2264226 CAP50, ANX11 NM 001157 (ANXA11 ), transcript variant a, AATGGGTATCTAATAAATACT ILMNJ 808732 CAGCCAGCTCTGGAATGGTCTGG mRNA TAAGAGGTGG
Homo sapiens pterιn-4 alpha- carbinolamine
PHS, PCD, DCOH, GTGGGATGTGCCAGTGTCCCCACCAA
0348155907 411 6143 14330595 230 57262 231 57262 NM 000281 dehydratase/dimenzation cofactor of PCBD hepatocyte nuclear factor 1 alpha CACCAGGAATTTAGACCTTTTCCC
(PCBD1), mRNA
Homo sapiens collagen, type XVI, CCATGCCGATGGAGCAGCAGTACCCA
0344702664 1001 33923 345 1643 234 30179 23530179 FP1572, 447AA NM 001856 alpha 1 (COL16A1), mRNA CCCATGAAAACCATGAAGGGGCCT
Fold change XS XS+ 6 GFs pOS +no GFs pOS +πo GFs Synonyms Genbaπk Description Probe_Sequence Probe Id Probe_SequenceJ
Homo sapiens small nuclear
SNURF-SNRPN, CTCTGTTCACTCCACTGAAT πbonucleoprotein polypeptide N GGTCCACCTCCCCCAGGAATGCGTCC
0344648808 97553925 33621844 46068097 46168097 HCERN3, SMN, RT-LI, NM_022805 GCAACCCATATAGTTTCTTG ILMNJI 729617
(SNRPN), transcript variant 2, ACCAAGACCTTAGCATACTGTTGA
SM-D, SNRNP-N CACAAGGTGC mRNA
Homo sapiens RAB7, member RAS GCTGGGGCCCGGGGATCTA
RAB7L, GCAAGTGACATCAGCTGGCTGTGATG
0324503107 34873096 11316428 161 70178 162 70178 NM 003929 oncogene family-like 1 (RAB7L1 ), ATTGTTTAGAGAGCCCCAAA ILMNJ 669753 DKFZp686P1051 CTTCGAAATAGGTCTGCTCCTCAC mRNA AGTGGCTCAGA
Homo sapiens F-box and leucine-
FBL2, FBL3, GCTCGGAGTCTGTGTTGCCTGATTGG
0321629554 33549762 10790595 18844762 18944762 NM 012157 πch repeat protein 2 (FBXL2), DKFZP564P0622 AAAGTAGAAGCTCTGGTGTATGCT mRNA
Homo sapiens
CTCTCTGTATGACAACTCTACAGAAGT
0320342906 8540643 27359344 4077726 4087726 AGU, ASRG, GA NM 000027 aspartylglucosaminidase (AGA), TGTGCGCGTGCTTTCTCAGCAGC mRNA
Homo sapiens fibroblast growth CCAGGGCGGTTCCAAACTCT
AATGATGGAAGGAAGACTGGGTTGCA
0319156288 7442726 23753928 35362262 35462262 FGFR5, FHFR NM 021923 factor receptor-like 1 (FGFRL1), AAACCGTTCCCACCGTCAGG ILMNJ 775956 GGGACTGTGGTCTCTCCTGGGGCC transcript variant 3, mRNA GAGACCTACA
TGCATCCGACACCCACCCCC
THIF, EST01027, Homo sapiens thioredoxin CAGCCATAGCACTTTGTTCACTGTCCT
0314364607 35498096 11159345 2654226 2664226 NM 006472 TCTTTGTGTACTTCAGTCTTG ILMNJ698297 VDUP1. HHCPA78 interacting protein (TXNIP), mRNA GTGTCAGAGCACTGAGCTCCACC GAGTTTGGA
MGC5179,
ZC3HDC5L, Homo sapiens unkempt homolog ACTAGGAGGAAGGGGGCAG
TCTGTGCGCCTGCGCCTCGGAGAGCA
0313860666 16736844 5253037 91 239296 92239296 FU12623, KIAA0734, NMJJ23076 (Drosophιla)-hke (UNKL), transcript AGAGAGTTATGACCCCGAGA ILMNJ 734660 AGTGAAGGAGCATCATGGGTTTTG
ZC3H5L, C16orf28, variant 1 , mRNA GGGCGCACAGA
FLJ23360
Homo sapiens selenoprotein M GAATACTTCTCTTGCTGAGAGCCGATG
0312664152 47115977 14731477 11802144 11812144 MGC40146, SEPM NM_080430 (SELM), mRNA CCCGTCCCCGGGCCAGCAGGGAT
Homo sapiens cysteine-rich with
GGTGGCTGCTAGAGCTTTGGCCCCTG
031251618 28816428 90056 12421011 12521011 S5= --°<™ EGF-likβ domains 1 (CRELD1), CTTAGGATTAGGTGGTCCTCACAG transcript variant 1 , mRNA Homo sapiens cellular repressor of AGCAAGTGCCTCGGCCCAG
CCAGCTTCAGCCAGGGACAAAATCCC
0309020538 5079143 15695595 17647263 17747263 CREG NMJD03851 E1A-stιmulatθd genes 1 (CREG1), TCTTCCTGTATTTATGTGGAA ILMNJ 701629 CTCCCAAACCACTCTCCACAGCTT mRNA GGCGGCGGCT
DKFZp686l10125,
MLCK108, FLJ12216, Homo sapiens myosin light chain
AGAGCTGGAGAACTCCATGTACTTTG
0303648113 10260977 311 57263 4100393 411 0393 MSTP083, KRP, NM_053032 kinase (MYLK), transcript variant 8, GAATCTCCTCCAAGATAGCCAGAG
MLCK210, smMLCK, mRNA
MLCK, MYLK1
MGC138864,
Homo sapiens deltex 3 homolog AAGGGAGGGTCTCTTGATTCCTAACC
0303183999 17993095 54 552185 97 264465 98264465 FLJ34766, NM 178502 (Drosophila) (DTX3), mRNA GCCCCCACATACTGCTCCACCGCT MGC138863, RNF154
MGC131937, FLJ21478, NOD26, Homo sapiens NLR family member
GGATGCCCTCACATTGGTGCTTTCTCC
0285947305 30960596 88 53099 12062262 121 62262 NOD9. CLR11 3, NM 170722 X1 (NLRX1), transcript variant 2, TCATCCTCATGCCCCCTTTGCCA NOD5, DLNB26, mRNA MGC21025
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens ubiquitin-conjugating AGGAGCTGGAATATGGGGA
UBCH8, RIG-B, CCTCCAGCATTCAGTCCAGGGGGAGC
028578188 1401 6143 400 55597 934 881 935881 NM 004223 enzyme E2L 6 (UBE2L6), transαipt GTCAGCGAGGACGGTGGGG ILMNJ 659773 MGC40331 CACGGAAACCATGTTCTTGCTTAA variant 1, mRNA CCAGGAGCCCTT
TSA-1, RIGE, RIG-E, Homo sapiens lymphocyte antigen 6 CAGGGAGACCGTGTCAGTAGGGATGT
0285279011 6349 1562 1811 281 54193975 54203975 NM 002346
SCA2, SCA-2 complex, locus E (LY6E), mRNA GTGCCTGGCTGTGTACGTGGGTGT
Homo sapiens nudix (nucleoside
CCGGACATCCCCAAGACCCTCGGCGT
0280661916 419 16428 11764345 20649762 207 49762 UGPP NM_177533 diphosphate linked moiety X)-type CATCTTTGGTGTCTCATGGTTCCT motif 14 (NUDT14), mRNA
GAATGCTATCATCCTGCTTG
PKD, PKCM, PKC-MU, Homo sapiens protein kinase D1 AGACAATGCACCTAGCTGTGCAAGAC
0280407363 441 34344 123 75595 151 37262 152 37262 1 NM 002742 CCTGTCCATTTGTGGAACAG
PRKCM (PRKD1), mRNA CTAGTGCTCTTAAGCCTAAATGCC CATCTGGTGA AAAGTGATGGCGAGCGACC
DKFZp686L17253, Homo sapiens SID1 transmembrane GGGCTGGGAGATGAGGTGGGTCTGG
0278116464 13290809 36963928 33351428 334 51428 NM 001040455 ACCGAGAGGCGCTGCTGGA ILMNJ 754827 CGI-40, FLJ90656 family, member 2 (SIDT2), mRNA ATCTTTTCTCAGAGCGTCTCCATGC CAGGGAGAGCGA
Homo sapiens PYD and CARD CAGAAGGCAACGCTTCTCTT
TMS 1, MGC 10332, ACGTTGAGTGGCTGCTGGATGCTCTG
0261287789 565 34766 147 71844 307 16846 308 16846 NM 013258 domain containing (PYCARD), TCTGGTCAAAATGGCTGGTA ILMNJ 759453 ASC, CARD5 TACGGGAAGGTCCTGACGGATGAG transαipt variant 1 , mRNA AGCAGGCCGT
Homo sapiens Enah/Vasp-like CAGCTCCGTCCCCAGCGCTCATGGTG
024709248 15196643 37549762 705 9518 706 9518 RNB6 NM 016337 (EVL), mRNA TTGAAACTGTCTGTCATGCACCAC
Homo sapiens FYN oncogene CCTCGGGTGGCCAACTTGCT
CAGCGGAACCGCCCAGGATCAGATTG
0246843604 37043512 91 43954 1983393 1993393 MGC45350, SYN, SLK NM_153047 related to SRC, FGR, YES (FYN), ATCTGGTGGGTGACTTGGG ILMNJ 715901 CATGTGACTCTGAAGCTGACGAAC transcript variant 2, mRNA GACTAGAAAGA
Homo sapiens guanidinoacetate N-
ACGACACGTACCCACTCTCGGAGGAG
0245369312 427 3393 104 85595 36805597 36905597 TP53I2, PIG2 NM_000156 mβthyltransferasβ (GAMT), ACCTGGCACACACACCAGTTCAAC transcript variant 1 , mRNA
GCCCTGGTCCCGAGTGGCG
Homo sapiens fibulin 1 (FBLN1), TCACCAGGGGAATGGCTGGGATTTCT
0244972272 6280 1226 15384559 2321 8977 23228977 FBLN NM_006486 TGGGGACGGGCCATCACTG ILMNJ 766346 transcript variant D, mRNA CGGCACTCTGCATCATCCATCTTT TATGTATTAAAA
ADAR2a, ADAR2,
DRABA2, DRADA2, Homo sapiens adenosine
AGAGGTGTTGGCTGGACCC
ADAR2a-L1, ADAR2a- deaminase, RNA-specific, B1 TACACCACACGTTACAACTGCATGAGC
0234412734 472 5893 11078095 13008095 131 08095 CTCCTGGCTCCTACAAAGTG ILMNJ654960
L2, ADAR2g, ADAR2c, NM-001 1 12 (RED1 homolog rat) (ADARB1), TTCCTCTCGCACAAGACCAGCTG GAAATGGCTCG
RED1, ADAR2a-L3, transαipt variant 1 , mRNA
ADAR2b, ADAR2d
Homo sapiens coatomer protein GCTGTTTTCAGCCATGTTTC
TTCCCCAATCCTGGCAAAAGCCCAAAG
023370653 85333923 19943095 30670593 307 70593 MGC23008 NM 016429 complex, subunit zeta 2 (COPZ2), TCTGTGCATCTCCAGTAAGC ILMNJ 729640 ATCCCAGGGTCAGGAGAGACCCC mRNA AGAAGGCTAC
Homo sapiens fumarylacetoacetate
CGGCTCCATGTTGGAACTGTCGTGGA
0232070062 662 86426 153 83095 42298096 42398096 NM 000137 hydrolase (fumarylacetoacetase) AGGGAACGAAGCCCATAGACCTGG (FAH), mRNA
Homo sapiens chromobox homolog CTGGGGGCAGGCGCTGTGCTTCTGTG
0227004272 12051012 27 356312 8024065 81 24065 NM 175709 7 (CBX7), mRNA AGGTGGTTTAGCTTTTGCTTTCGA
Fold change XS XS+ 6 GFs pOS +no GFs pOS +no GFs Synonyms Gβnbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens Cbp/p300-ιnteractιng transactivator, with Glu/Asp-πch GTTCTGGATCAGGAAAGTCATACTGTT
0209537531 11513798 24125728 63941807 63951807 P35SRJ, MRG1 NM_006079 carboxy-terminal domain, 2 CACTTTCAAGTTGGCTGTCCCCC (CITED2), mRNA
NGX6, RP11- Homo sapiens chromosome 9 open GCATCAGAAGGAACTGGAAA
TTCCACCACGTTCTCCGAGGGTTTGG
0202216313 27856845 56331085 82910965 83910965 112J3 10, NM.016446 reading frame 127 (C9orf127), ACGTGGCACAACCCCCTCAA ILMN_1659306
MGC120460, NAG-5 mRNA GCTCCGCACC GAATGTCTGTGCCTTCACTGTGTC
Homo sapiens revβrsion-induαng-
AAGCTTTCAGAATATGTCAGTGCTGAT
0191625889 12020476 23034344 28257678 28357678 ST15, hRECK NM 021111 cystoine-πch protein with kazal GTAGCATGCTTGTTGCAATTGCC motifs (RECK), mRNA
Homo sapiens adenylate kinase 3- like 1 (AK3L1), nuclear gene GGGGTTGAGCAGAATGTTGTACTAGC
0191468412 29843927 57141693 7026468 7126468 AK4, AK3 NM 013410 encoding mitochondrial protein, TGTGCCTGGACTGAGTATAACAGC transcript variant 6, mRNA
Homo sapiens chromosome 1 open GAACGATGCCGTGTCCAGTTTGCGAA
0181433944 75331433 13667679 3542768 3552768 FLJ23221 NM 024579 reading frame 54 (C1orf54), mRNA GTCCTATTCCCCTCCTCCTGTCGC
GTCTTGAGGATATGGGAAGC
Homo sapiens serine dehydratase- GCCCATGGACAGTCCTGTGTCTGGAT
0161660748 23533928 38045124 14824762 14924762 SDS-RS1 NM_138432 CTAGAGAAACGCAAGCAGAC like (SDSL), mRNA GAGGAGGACTCAGTGCTGGCAGAT TGGATTGGGA
Homo sapiens acylphosphatase 2, TGGCTGGGTGAAGAATACCAGCAAAG
0158183471 43928094 69486984 11769765 11869765 ACYP, ACYM NM 138448 muscle type (ACYP2), mRNA GCACCGTGACAGGCCAAGTGCAGG
Homo sapiens nbosomal protein CACTGCAGATGCGGTCACCT
AGAGCAGCCCAGGTGGTCATCAGAGT
0150562473 960881 14467262 28913928 29013928 NM 001030001 S29 (RPS29), transcript variant 2, GACTGACCACCTGGGTTTTC CACCAATGCCAATGCCAGCCTGCA mRNA TATTACCAGT
GGCCATCTGTGGCTGGAGG
AM2, FU21135, Homo sapiens adrenomedullin 2 CGCCCTAACAACTTCCCATCCGCTGAC
0149965271 5629226 8441884 58469288 59469288 NM 024866 GTTCTGAATGTCCTCTCTCC ILMNJ 734184 dJ579N164 (ADM2), mRNA CCCTCCAACGCCATCAATCTCCA ATGTCAGGCAG
ICAP-1 alpha,
Homo sapiens calcium/calmodulin- AAAGTCGCATCAGAGAGCTG MGC22256, TATGACCGACAAGGCACCTCCTGGTG
014942023 8031806 12001143 24240642 24250642 NM 018584 dependent protein kinase Il inhibitor AGGGTAAGACTCAGGTGTCC ILMNJ 661627 PRO1489, RP11- TCTAACTCCCCCAAAGACAATGAG
1 (CAMK2N1), mRNA TGACTCCCAG 401M16 1
Homo sapiens retinoic acid receptor
MGC8906, HRASLS4, GGCCACGGCGCTTGGAATCCTGGTTG
0140246942 109093445 15300022 680383 690383 NM 004585 responder (tazarotene induced) 3 TIG3, RIG1 TTGCTGGATGCTCTTTTGCGATTA
(RARRES3), mRNA
Homo sapiens regulator of G- TGACTCTTACCCAGCGCATG
CTGCAGTGTCCGTTATGAGTGCCAAAA
0134345299 43083093 5788011 3044726 3054726 G0S8 NM 002923 protein signalling 2, 24kDa (RGS2), TCTTTATCAGTGTGTACTCG ILMNJ652434 ATCTGTCTTGAAGGCAGCTACAC mRNA TGACGATTTG
MGC138902,
FLJ31627, Homo sapiens prickle homolog 1 CTGTGCATCTTATTGTGAGGCCAGCTT
0128826756 7480476 96368546 25738513 25838513 MGC138903, RILP, NM-153026 (Drosophila) (PRICKLE1), mRNA GTCCCCTCGAACCCTCTTTGGCC
FLJ31937
Homo sapiens pregnancy specific TAAGTAAGTCAGGTCCCTAA
PSBG2, PSGGB, CEA,
0126176324 16693929 21063786 120884796 121884796 NM 031246 beta-1 -glycoprotein 2 (PSG2), GCCCCGTCCCAAGAAGTGA ILMNJ765746 CCAACATAGCAGCTGTGATGTCATTTC PSG1 mRNA CACAAGTGGCC TGTATTTCAGGAAGACTGGCAGG
Homo sapiens pregnancy specific AATTCCTACTTCACTAACCCT
CCAAAGATGTCAGAACAAGACTCCCCA
0109503583 21353726 23383095 65916846 66016846 PSG9 beta-1 -glycoprotein 4 (PSG4), TCCTTATCCTGCCACCTCGC ILMNJ740104 transcript variant 1 , mRNA CGGGGGCCA TCATGATAAGGCTCCCACCCCTC
Fold change XS XS+ β GFs pOS +no GFs pOS +no GFs Synonyms Geπbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens damage-regulated CACTGAGAACGCCTGCCAG
CTTCTGCCTCACTTCGAGCAGACTTTT
0 105854725 6043 756 63976013 771 506 772 506 FLJ11259 NM_018370 autophagy modulator (DRAM), CTTCCCCATGCCCTCACTTG ILMN_1707232 GTTCTCGGCGCTCCTCACGATGG mRNA GTTTGTGTTTT
Homo sapiens pregnancy specific
GCTAAATGGTCAGAGCCTCCCTGTCA
0 104732912 21844226 22878094 507 6976 5086976 PSG9 NM_002780 beta-1 -glycoprotein 4 (PSG4), GTCCCAGGGTAAAGCGACCCATTG transcript variant 1 , mRNA
Homo sapiens ADAMTS-like 4 AGCGTGCGGAGCATCTGAA
GGGTAACCACGCCCAGGACACCTCAG
0076132985 476 5976 36284798 10951433 110 51433 TSRC1 NM_025008 (ADAMTSL4), transcript variant 2, GTTGCAGTCTTGCGTGTGGA ILMNJ 784737 CCTTTCCAGCATAGCTCAATAAAC mRNA TGGTGCAGCCA
Homo sapiens Fc fragment of IgG, AAGACAAGCAGGAGGGTCG
TGTGATTCCAGCCACCGCCTGACCAT
0067751851 94068506 63733154 18640178 187 40178 FCRN, alpha-chain NM_004107 receptor, transporter, alpha ACATGGACTGAAATCACCCT ILMNJ 734508 CCGCCATTCCGACTGCTAAAAGCG
(FCGRT)1 mRNA CTGCAGCTGGG
Homo sapiens collagen, type IV,
CAGATGTGTGCAATGTGGCAAACTGA
0042392629 194 09761 8228308 30635596 307 35596 MGC88184 NM 001847 alpha 6 (COL4A6), transcript variant AGCTGCACAGTGTTGGTTTCCTTG
A, mRNA
RTP801, Dιg2,
Homo sapiens DNA-damage- REDD1, FLJ20500, GCTGCGTTTAAGCCTTCCCCCATCGT
0038494152 2721 6726 10476848 54837307 55837307 NM 019058 inducible transcript 4 (DDIT4), RP11-442H21 1, GTACTGCAGAGTTGAGCTGGCAGG mRNA REDD-1
Homo sap.ens cellular retinoic acd ATTTTGGGGGTCTGTAC™ ILMN 1702691 CCAAGTCAGCAGTCCTAGCCCCAAAC
0022994124 49538095 11 390851 793989 803989 CRABP-II, RBP6 NM_001878 binding protein 2 (CRABP2), mRNA '" -■ ■ —" ■ CAGCCCAGAGCAGGGTCTCTCTAA
Homo sapiens hypothetical protein CCTGGTCAAAGAGAGCTACGTTTGGG
0014212892 1171 4476 16649658 115 31845 116 31845 NM 177964 LOC130576 (LOC130576), mRNA CAGTTCTGCAGAGAGGATCCTGGC
Homo sapiens insulin-like growth GGCGGGGGCCGGGCTTGGA
0006603313 12596923 83 18143 15205518 1521 5518 IBP5 NM 000599 factor binding protein 5 (IGFBPS), AC GATGTAC GATAC C CTCAT ILMNJ665095 mRNA AGTGACCATTA
Figure imgf000111_0001
TABLE 11
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequβnce Probejd Probe_SβquenceJ
GCCACTTAACAGCTCTGGGTCC
9658 6593893 6566969 7 3681846 WFDC1 ILMN_1751028 CTGTTTTACCATCCTGGGAGCA AGGCCC
CACCGATGACAACAGAGGAAGA
1053 76 33146 7 2162538 7 288069 PTGFRN FUriOOi ' SMAP-6 NM-020440 receptor negative AGGGAACTGGGATTTGGGTAAG TTCTCC
TGTTTGATCCACCCCCTTCCCT
1842 14662262 8 171854 7 7511916 C10ORF54 G'24' NM_022153 ILMNJ663447 GAAAATCCTGGGAGGTTTTATT GCTGCC
CTGTGCAGCCTTGGTGGCAAAT
3981 307 39764 6 745281 9418619 ITGA11 HsT18964 NM 012211 ILMNJI 768556 ATCTCATCTGCCGGCCCCCAGG
Figure imgf000112_0001
ACAAGT
Homo sapiens ADAM metallopeptidase with TGGTGGTGTCCAGCGGCGCCT
3357 19876428 57550135 6493353 ADAMTS7 ^ffttt"204' NM_014272 thrombospondin type 1 GGTCAAGTGTGTCAACACCCAG motif, 7 (ADAMTS7), ACAGGGC mRNA
Homo sapiens vav 3 guanine nucleotide CTTTGTCTTGCCTGTATGCAGC
2975 23040594 7995535 76548815 VAV3 FLJ40431 NM_006113 exchange factor CCTCGTGTAATACGGTGAATTA (VAV3), transcript GAGTGG variant 1 , mRNA Homo sapiens dehydrogeπase/reducta TGACCCCCACAGGGAGGCAGG rβtSDRI SDR1 7537 489 1726 7 4008894 59536495 DHRS3 Rβdrt RDH17 ' NM_004753 se (SDR family) AAAACAGCCAGAAGCCACCTTG member 3 (DHRS3), ACACTTT mRNA
Homo sapiens death-
GCAGAAGAGGGTGTGTTTGAAA
DAPK, associated protein
1444 121 297615 7 1823564 9777615 DAPK1 NM 004938 TCATCGGAGTCAGCCAGGAGCT DKFZp7811035 kinase 1 (DAPK1), GTCACC mRNA
CTAGGGGTTTGGGGTG
Homo sapiens GTCCCTATGCTGACCCCAATAC
H2-Bf, CFAB, BFD, GGTGACTTAGGGGCGG
1958 16503094 7 0495872 10288898 CFB NM 001710 complement factor B ILMN 1805126 TTGCAGAGGTGATTCTGGCGGC BF, GBG, PBF2 CTTTTGTGTTCTCCCTC (CFB), mRNA CCCTTG
T
Homo sapiens
AGTCAACACCTACTATG complement GGCAGCCCCGAAACCTGCCTAA
TACCAGGCACCAGGAA
63 14 556 3143 8450003 9812315 C1R NM 001733 component 1 , r ILMN 1734655 TGGTGACTTCCGTTACACCACC GCCAGAAGCTCAGGGC subcomponent (C1 R), ACAATG C mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probβ_Sequence Probβjd Probe_Sβquβnce_l
Homo sapiens C-type GGGGCAACCCCCTTCA
CCCGCATCGCCTACAAGAACTG
TN, TNA, lectin domain family 3, TTTATCTCGTGAGCGG
13 3 11548929 68430586 11 048524 CLEC3B NM 003278 ILMNJ 712313 GGAGACTGAGATCACCGCGCAA
DKFZp686H 17246 member B (CLEC3B), TATCGGAAGCTCCATTT CCCGAT mRNA G
Homo sapiens poliovirus receptor-
GATGCTCTGTCCTATAGCAGCC
PVRR2, HVEB, related 2 (herpesvirus
5913 51 319107 8547511 9686537 PVRL2 NM 001042724 CCTCTGATTCCTACCAGGGCAA PRR2, CD112 entry mediator B) AGGCTT (PVRL2), transcript variant delta, mRNA
Homo sapiens nuclear
GAGTCTGTTTGCTGTTA factor of activated T- TCAGCCCCCTGCCAGAGTCACT ATTTCTTTGTGGGGGC
6699 6055719 8 341914 10577591 NFATC4 NFAT3, NF-ATC4 NM 004554 cells, cytoplasmic, ILMN 1727813 GCCCCATAATCACCATGTCAGA AGCAGGAGCCTCTCAG calcineurin-dependent AGGGAC C 4 (NFATC4), mRNA
Homo sapiens
GTCTGCATTTTGGAGAGTCCAC DENN/MAOD domain
4236 4366072 11 3614855 9471571 DENND3 KIAA0870 NM 014957 ACCACGGACCAGGTTTTCCCCC containing 3 AAGGCT (DENND3), mRNA
GGGTAAGAAATGAGCC
MGC70561, CAGAGCAGGCAGAGCACCAGC
Homo sapiens vitnn TAGTCACCAAGAACTC
1599 12694762 6 540902 10772864 VIT DKFZp313L1517, NM 053276 ILMN 1696087 AAGTGCTGCTTTACTAACTGAC (VIT), mRNA CACCCCCAGAGGAAGT
MGC149746 GTGTTGG GG
Homo sapiens leptin AGGCTACGTGGGAGAC
TGGGAAGATGTTCCGAACCCCA receptor (LEPR), TCGGCGCTGCAGCTGG
1409 11462262 5968002 11 407572 LEPR OBR, CD295 NM 001003680 ILMN 1702636 AGAATTGTTCCTGGGCACAAGG transcript variant 3, AGAGAATCAACGTCTA ACTTAA mRNA CT
Homo sapiens
AGAGCATGTGACCCTGAACCAG
FLJ23849, chromosome 10 open
9849 94 84346 11 585701 8 145906 C10ORF33 NM 032709 CTCTGACCCAGGAAGAAGACTC MGC 13047 reading frame 33 CACCCC (C1Oorf33), mRNA
Homo sapiens alcohol GCGAAACCTGTATCCG
HOT, FLJ32430, CCAGGCTCGACTTCAGGGGTCA dehydrogenase, iron GGCCCAACCTGAAAAC
5438 53527428 11 897458 8204365 ADHFE1 ADH8, MGC48605, NM 144650 ILMN 1785272 GTGTTCCTGTCCCAAACCCCAC containing, 1 ATCCCAGCCAAGAACT
HMFT2263 ACAGAA (ADHFE1), mRNA GG
Homo sap.ens HERV-H MCCjGCCACJACATTC
ATCTGAGCCTCCCGCAGAGGAA
LTR-associating 3
6553 6869252 894445 12277002 HHLA3 NM 001031693 TGGTTTACATTAGTTAC ILMNJ 715814 TGCAGAATGACGCCACGGCACG (HHLA3), transcript TTCATGCTGGCTGGGG CAGGAT variant 1 , mRNA
_ . „ CAGGTTTCCTGCAGCT Homo sapiens RAS- .„„ „ „„ AGAAGAGCCTCCATCATCCCTC
6 055 50963234 74994097 10732244 RASL11A NM 206827 like, family 11, member ™ ILMNJ750596 GGCCCCGCTCTCCCAACATGCA A (RASL11 A), mRNA TGTAGGGGAAGGAGCC GGACCT
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens
GCGCCTGGATTCTGCC extracellular matrix GCACCACTGGTCATAGCATCTA
MGC126355, ATTGCGACACATTTTTG
26 1 24921011 12 398535 79340425 ECM2 NM 001393 protein 2, female organ ILMN 1715636 TCTCCTTTGCCTTAATTTACTGA MGC126356 TGCCTTTCAGCCCCTG and adipocyte specific AATAC (ECM2), mRNA
Homo sapiens TBC1
GGCACTGATTCCGACCAGGGCA domain family, member
6938 71 65485 8428581 12 723093 TBC1D3G NM 001040282 CCCCCTTCAGAGCTAGGGACGA 3G (TBC1D3G), ACAGCA mRNA
Homo sapiens interleukin 18 binding GCAGCTGCTTCGGATCCACACT
4982 51 401573 12 797788 8382192 IL18BP IL18BPa NM 173042 protein (IL18BP), GTATCTGTGTCATCCCCACATG transcript variant A, GGTCCT mRNA
TAGGGCCTGGGGATTT
Homo sapiens CCTGGCCACCGACTATGAGAAC GGGTCAGTTGTAGTTG
42 71 384 8643 7 101533 12654845 APOD NM 001647 apofipoprotein D ILMN 1690614 TATGCCCTCGTGTATTCCTGTAC CCTCTCCCCCACCCTC (APOD), mRNA CTGCA
Homo sapiens opposite CGAGAAGCAGATGACA
ACACCTTGTAAGTGTCCCCTCT strand transcription unit GGCTCAGGCCTTACCA
9 004 77 18435 132048435 53930697 GATS DKFZp686B07267 NM_178831 GGTTTCCTCGGTGGTGGCGCC to STAG3 (GATS), GGGATGCACTTGCCAC " CTGAACT mRNA AT
Homo sapiens
AAATTGAGGTGGGGGTGTCAGA
MGC2650, TRS33, trafficking protein
5738 57 957413 9637452 11 523018 TRAPPC6A NM 024108 GGAGGCAAAGGGGTCCCAGCT HSPC289 particle complex 6A GCGGTCA (TRAPPC6A), mRNA
Homo sapiens yippee- GTATGGAGCTGTTGCGGGTTTG
DKFZp761C2021,
549 57 91084 8360489 13403777 YPEL2 NM 001005404 like 2 (Drosophila) CTCC I I I I I CTTGCTTTGCGTGC FKSG4 (YPEL2), mRNA TCAGT
PC3, TIS21, Homo sapiens BTG CCAAACACTCTCCCTACCCATTC
1068 131 00595 11 924184 12 725094 BTG2 MGC126064, NM 006763 family, member 2 CTGCCAGCTCTGCCTCCTTTTC
MGC126063 (BTG2), mRNA AACTC Homo sapiens ATGGGCCCTACAGTCCCTGGGC
2871 330 7101 13804459 9680338 ADCY4 NM 139247 adenylate cyclase 4 TACACCTGCTACAGCCGGGGTG (ADCY4), mRNA TCATCA Homo sapiens ubiquitin TCAGCAAAGTCATACACTCCCT
2036 222 20178 10916097 11 747284 UBL4B FLJ25690 NM 203412 like 4B (UBL4B), GTGGCCAGCGTGAACAGAGCC mRNA ATGCCCC
Homo sapiens
DKFZP761L0424, GCAAGTGTGGTGCCTTGGATGT KIAA1217 (KIAA1217),
7 724 71 55003 5955261 14 534442 KIAA1217 RP11 -324E23 1 , NM 001098500 GGCCTGTTGGCTCGCTTTCTTC transcript variant 2, MGC31990, SKT TCTGTG mRNA
Homo sapiens vav 3
GTGAGATGAAAGAAGA guanine nucleotide GTTGCATTTCATGGGCCTGGGG GCCTACTAGTGAGAAG
6772 6646344 63943424 14949141 VAV3 FLJ40431 NM 006113 exchange factor ILMN 1769540 GTTTCCTAGCAGAGGATATTGG AAGTTGGAGGATGAAG (VAV3), transcript AGCCCC GA variant 1 , mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens trefoil GCCTGATGTCTTAACGAATAAA
TFI, hP1 B, HITF,
6 142 7359032 10961201 14258721 TFF3 NM 003226 factor 3 (intestinal) GGTCCCATGCTCCACCCGAGGA ITF (TFF3), mRNA CAGTTC
Homo sapiens ubiquitin ACTGAGTATGTTCATTG
TCAATGGAGCCCCGGATCCCAA like modifier activating CCACCCCTGTCCTCCC 179117a
1923 222 83095 8369144 15850397 UBΛ7 %££%&„ NM.003335 GCCCTGCATTGTAAGCCCACAG enzyme 7 (UBA7), CTGGGCACCCCTCACT - TAGGCA mRNA T
V, CALDAG-GEFI,
Homo sapiens RAS CALDAG-GEFII, GCCGGTGACTGGACAT guanyl releasing TCAAGCCTAGTGTAAATTTCTGC ATCACCTCTACTTAAAT
7985 93 12684 8 389942 16 046589 RASGRP1 "ϋ^9,9"' NM_005739 protein 1 (calcium and ILMN 1713124 ATCTCACACGACTTTAGTTTGGC
RASGRP, CCGTCCTGTTTAGCGA DAG-regulated) CAGG
MGC 129998, C (RASGRP1), mRNA hRasGRPI
TCCTCCAGCTGCAAGA
Homo sapiens GTTAGCCTTGCATATCCCTTCTG AGGGAGCCATGAGCCA
4261 51 18611 10705215 14806075 ARSG KIAA1001 NM 014960 arylsulfatase G ILMN 1697412 TATCCTGTCCCTCCTCCACGCC
GAAGGAGGCCCCTTTC (ARSG), mRNA GACCC
CA
Homo sapiens similar
CCCTGAACAGACTCGAAGGGTC to RIKEN CDNA
12 36 107 74762 5838048 16430946 LOC388135 MGC131524 NM_001039614 ACGAGGAACAGCAGCACCCAGA 6030419C 18 gene CAGTGT (LOC388135), mRNA
Homo sapiens
CAGGCAGCTCTGGGACCTAGGA junctophiliπ 2 (JPH2),
8 145 98614334 16099365 9638924 JPH2 JP2, JP-2, FLJ40969 NM_020433 GTTTGCTTCTGATAGGGTCAGC transcript variant 1 ,
TTTCCC mRNA
Homo sapiens ring CCAGAATGGAAGGGGGTGGGG
4717 60206085 15071852 11 7032585 RNF122 ^H^ NM_024787 finger protein 122 ATTTTCTGTTCCTCCCTGGAGTG
(RNF122), mRNA GGTGAG
Homo sapiens GCAGGGAAAACTGCGG
CCAGGTGCCCTCCAACTTAGCC
RAB33A, member RAS CTGCAAAAATGGTACCT
5335 58 177677 1625819 8359183 RAB33A RabSIO, MGC1488 NM_004794 ILMN 1751345 CTGAAATTTGCTGATGCCCACA oncogene family GGCCACTTCGGACAAG ACATGC
(RAB33A), mRNA G
Homo sapiens serpin peptidase inhibitor, clade G (C1 inhibitor), GGGCAGAGGTGAAAAA
TGGGACCAGCAGCACAAGTTCC
C1NH, HAE2, C1 IN, member 1 , GAAGGAACAACAGCGA
4278 401 95593 60140285 17424347 SERPING1 NM 001032295 ILMNJ685760 CTGTCTTCATGGGGCGAGTATA HAE1. C1 INH (angioedema, GTCCGGATTTAAGGAG TGACCC hereditary) GC
(SERPING1), transcript variant 2, mRNA
Homo sapiens limb bud
MGC 163287, GTCCCTAGACCACTTTGTATGA and heart development
807 942 5893 17 46439 8366522 LBH MGC104312, NM 030915 CCGTTTGCAGTCTGAGCAGGCC homolog (mouse) DKFZP566J091 AGGGGC (LBH), mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probβ_Sequence Probe Id Probe SβquencθJ
Homo sapiens MACRO ACGCTGCGAGAGTGGCTGGAG
5 353 804065 15 077138 15606528 MACROD1 LRP16 NM 014067 domain containing 1 CAGCACAAGGACAAGGTGGACC (MACROD1), mRNA GGCTGAT
Homo sapiens
VE-JAM, PRO245, GCAGCCGTAGTAGTTGTGGCCT junctional adhesion
3049 421 83096 15515303 13398872 JAM2 JAMB, VEJAM, JAM- NM_021219 TAGTGATTTCCGTTTGTGGCCTT molecule 2 (JAM2),
B, CD322, C21orf43 GGTGT mRNA
Homo sapiens XIAP TGCTTAAAGGCAGAGC
TCTGGGCCCTACAGCCTGGAGA
HSXIAP AF1, associated factor 1 CGCCTGGTTGGTCTCC
8468 119 98512 14805477 14789437 XAF 1 NM 199139 ILMN_1812489 ACCTGGAGAATCCTACACCCAC BIRC4BP (XAF1), transcript ACCCTGTGCATTGGGA AGAACC variant 2, mRNA GC
Homo sapiens ACCTCCCTGGATAGCA
CAAGCACATGATAGTGGGCGAT chromosome 22 open GGAACTTGACCTGCCA
1065 12421428 18 940153 74639544 C22ORF36 MGC131773 NM 207644 ILMNJ 673555 GAAGGTCAAGGAGGACTCACAG reading frame 36 TGTGTGCCCTGCCTTC GCCCCC (C22orf36), mRNA CT
PREDICTED Homo
CCACCCAACCCGGTGGTTAACG sapiens PDZ domain
4852 62 587822 11 104998 17 170095 PDZRN3 XM 001133042 ATTTAATACATATAACCAAACCG containing RING finger GCAGC 3 (PDZRN3), mRNA
OPS, LR3, EVR4, Homo sapiens low TAACCTGCCTGTGTCC
ACTACCTGGATTTGAACTCGGA EVR1. BMND1, density lipoprotein ATGGCGAACCCTCTAC
4 064 6628836 18013142 15316745 LRP5 NM 002335 ILMN 1814487 CTCAGACCCCTATCCACCCCCA HBM, VBCH2, LRP7, receptor-related protein ATCCTAACCTGCCGGC CCCACG OPTA1. OPPG 5 (LRP5), mRNA GA
PREDICTED Homo
GAGTTCGAGTCTGTCTGAAACC sapiens katanin p60
3 16 52 734077 14074348 19933693 KATN AL2 XM 001129888 ACATTTACCCTGACCTGGCCAC subunit A-like 2 AAAGGC (KATNAL2), mRNA
MGC142208, Evι3, Homo sapiens zinc ACTCTGCAGTCTGAACCTGGAG
3062 5273545 19961712 15 132526 ZNF521 MGC142182, EHZF, NM_015461 finger protein 521 ATTACTGGAATTGTTTTCCAAGA DKFZp564D0764 (ZNF521), mRNA GGAAA
CACCCGACTTCGCAAC
Homo sapiens SMAD CCAGAGACACAGCCCCCACGGA
MADH6, HsT17432, ACTGGGGTTCAGGTGA
1554 17942679 6 74092 20433655 SMAD6 1 NM 005585 family member 6 ILMN 1805938 CAAAACCCCCCAGATATCATCTA MADH7 CTCATAACCATGTTGAG (SMAD6), mRNA CCTAG G
Homo sapiens Ras association GCATCTGGATGGTCAG
GATGCGTTTACTCATCTAACATA
(RalGDS/AF-6) domain CTTCATCCTCTCCACAC M 1 RBRnQ-
4222 584 2893 10474273 1982494 RASSF2 κrr1747' --— ATCTGACAGGGCCTCAGCAAGG family 2 (RASSF2), TGCCCTCCATTGGCTG ILMN-l bBbu8s GAGCC transcript variant 2, G mRNA
Homo sapiens SH3 and GTTGGGAACTGAGAGGGGATG
6942 8441091 7695239 2062691 STAC FLJ32331. STAC1 NM_003149 cysteine rich domain GCTGCTGGTTTCACAGAAGTTT (STAC), mRNA GGATGCC
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens zinc
ACCTGGTCAGCCTAAA finger and SCAN ACCTGGAGAGTGAAGACGGGC TCTTCCCAGTCCCGCT
3206 57996643 20774296 1605943 ZSCAN2 FLJ20595, ZFP29 NM_181877 domain containing 2 ILMN_1721225 ATGACGGCAGGTGAAGGGGTTT GTGGAGCTGTCAGTCA (ZSCAN2), transcript GCTGTGA CC variant 1 , mRNA
Homo sapiens sterile CACTGTCTCAGAGAGG
TCCCACGCTCTCAGGGGGGACA alpha motif domain TTTTCCTGTGCTCGCC
4 972 65 51621 15366575 13865348 SAMD14 FLJ36890 NM_174920 ILMN_1751851 TGCTCTCTCTTACCCTGTCACTT containing 14 CTGTTTCTCTCAGGAA GGTCT (SAMD14), mRNA GC
CGAGCCCAGAGGGATT
KIAA0137, Homo sapiens zinc CCAGGTGGGCACAGAGAAGGG
TTGCCGCTGCTTCCTC
3022 53 868073 1524472 21 075993 ZNF248 bA162G103, NM 021045 finger protein 248 ILMNJ 766904 TGGAGAGAGAATCTGGGAAGAG
TACCCCTGTATTTCACG MGC131882 (ZNF248), mRNA AAATGGA
C
Homo sapiens
GGGCTGCCTGAAGACG complement TCCCAAAAGGCAGGTGCAATGA
CLSPa, C1RL1, AAGAGAAAGAGCAAGG
1462 197 39345 14 988178 14675433 C1RL NM 016546 component 1 , r ILMNJ 779743 TGCACACTTATACCCCCAGCCA C1RLP, CIr-LP TTATTGTTGGCTCAGG subcomponent-like CTCAGG CC (C1 RL), mRNA Homo sapiens
TACCAGTCTGTCCTCACTGCCA gasdermin-like
5939 10686429 18 392096 1846216 GSDML PRO2521. PP4052 NM_001042471 TCGCCACTACCATCCTGTCACC (GSDML), transcript AGTGGG variant 1 , mRNA Homo sapiens proline AGTGGAGAGCAAACTT
GGTTGGAAATACCATCAGCCTT rich 5 (renal) (PRR5), CGAGGACGTACCCTGG
9675 11675597 1702741 11 109085 PRR5 PP610, FLJ20185 NM 001017530 ILMNJ 776674 CCTTGCTCGGCCCAGGTCTGTT transcript variant 4, AGGAGGTGGTCATGGC TCAGGC mRNA AG
Homo sapiens
RP11-230122 3, DENN/MADD domain ACTTAGGTGTTTCAGCATAGATT
2965 5072525 16975222 18 170595 DENND1A FLJ38464, NM_020946 containing 1A CCAGTTTCGCACCCTGGGCAGA
KIAA1608, FAM31A (DENND1A), transcript CCCCC variant 1 , mRNA
Homo sapiens vaccinia CGCATTGGCAATGCCA
ATGGTCCAGCACCGTCACCTCT related kinase 3 AAGGAGATGATGCTTT
3674 6424432 16879091 18952023 VRK3 NM 016440 ILMNJ 712563 CCCCGATTATCCCTCTTCTCAGA
(VRK3), transcript AGAAAAAAGATTTCTTG TGGTG variant 1 , mRNA A
PREDICTED Homo sapiens poly (ADP- GATGGCCATAAGGCGGTGTTCG
4 326 81 67314 16 164707 21 941345 PARP10 XM 001127571 ribose) polymerase TGGCACGGGTGCTGACTGGCG family, member 10 ACTACGG (PARP10), mRNA Homo sapiens
ACHRB, CMS1D, cholinergic receptor, CTGCAGCATGCCCAGTGCCACG
3289 55 166992 18362453 17 14515 CHRNB1 CHRNB, CMS2A, NM 000747 nicotinic, beta 1 CACAGGTGCTGACCTATAGTAA SCCMS (muscle) (CHRNB1), GTGCTT mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probβ_Sequence Probejd Probβ SequβπcβJ
Homo sapiens interferon regulatory GCCTCGGAACTGTGACACCCCC
3152 5617286 18423567 18314775 IRF7 IRF7A, IRF-7H NM 004029 factor 7 (IRF7), ATCTTCGACTTCAGAGTCTTCTT transcript variant b, CCAAG mRNA
Homo sapiens Meis TCACAGTGATGTCTGC
TCCAGCTTCAGGACCCCACCTC
DKFZp547H236, homeobox 3 (MEIS3), ATTCAACCTGCTGCATT
7082 117314285 19754322 15800739 MEIS3 NM 001009813 ILMNJ 779333 CAAAGGCCCCTCTGCTCAATGC MRG2 transcript variant 2, TGGTGACAAAGAGCCA CTACCT mRNA G
Homo sapiens tubulin
CTACCTCAAGGACAAG tyrosine ligase-like TCTGTATGATGAAGAATTGGCC
C22orf7, ATGCGCAAAGCGGTGG
4606 7934465 16429674 19515984 TTLL1 NM 012263 family, member 1 ILMN_1783728 CAGGGTGACGGGGCTGACCGG HS323M22B CTGAGGAGCTGGCCAA
(TTLL1), transcript GT GAGCTGA variant 1 , mRNA
Momo sapiens ChaC,
GCAGGCTGGATGAGGGATAGTA cation transport
6621 12070595 1955054 18101063 CHAC1 MGC4504 NM 024111 GGGCATGAGGAGAAGGAGCCC regulator homolog 1 (E
TGTAAGG colι) (CHAC1), mRNA
Homo sapiens family
GGTGCTTTGGCCCTAATAGCAC with sequence
6443 9571846 1001433 22997429 FAM84B BCMP101. NSE2 NMJ74911 TGGACAACACCACGACCACATG similarity 84, member B GAAACA (FAM84B), mRNA
Homo sapiens ATH1, AAAGCCGGTGCAGGCT
MGC129858, AATCCCAGGCTCCTCTTGACTC acid trehalase-like 1 CTGCTGTCATCGTCAG
882 14393094 23748478 11 128967 ATHL1 FLJ22635, NM 025092 ILMN_1760049 TGGGCAGCTTTAATCAGGTTGG (yeast) (ATHL1), GACTCCTTGTGGGCTG MGC129859 GCAGCC mRNA TG
Homo sapiens tumor
CAGGGCAAAAGGCAACTGCAGC
D53, MGC8556, protein D52-lιKe 1
5407 6188476 65615797 24462276 TPD52L1 NM 001003397 TTTCAGCAACGTTGGAACGGCC hD53, TPD52L2 (TPD52L1), transcript ATCAGC variant 4, mRNA
Homo sapiens
CGTGGAATGGGACAGT
RAB27, HsT18676, RAB27A, member RAS GAGGAAAAGATTTAGACATTTCA GGCTAGAGGTATGGAT
2 39 50708527 23337925 2004875 RAB27A GS2, MGC117246, NM 004580 oncogene family ILMN_1740949 AGAGCAGGGTTGGCCAGGCGC GGAGCAAGGTCAAATA RAM (RAB27A), transcript GGTGGC TG variant 1 , mRNA
Homo sapiens signal
GGATGAATGGAGAGGA transducer and GCCATGTGCTGCGTGCCTGTGG CAAAGGCAGCTTCTGA
1035 19909344 2481089 1565372 STAT5A MGF, STAT5 NM 003152 activator of ILMN_1694539 AATCTGGAGTGAGGGGTAAAAG CACACCAGCCCCAGGA transcription 5A CTGATC CC (STAT5A), mRNA Homo sapiens
TACATGTCCTATCACCTGTTCAT
MGC17150, glycoprotein M6B
3 542 6966217 20 386515 20305532 GPM6B NM 001001995 TGTGGCCTGTGCAGGAGCTGGT MGC54284, M6B (GPM6B), transcript GCCAC variant 1 , mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens mucin 1 ,
PEMT, PUM, PEM, CCCACCAATTTCTCGGACACTT cell surface associated
963 181 51845 16850765 22 77221 MUC1 EMA, H23AG, NM 001044390 CTCAGTGTGTGGAAGCTCATGT (MUC1 ), transcript MAM6, CD227 GGGCCC variant 5, mRNA
PGII, DSPG2, Homo sapiens decorin TCAACCTAGTCACAGAGCAGCA
6588 138 19345 20784874 21 869213 DCN CSCD, PGS2, NM_001920 (DCN), transcript CCTACCCCCTCCTCCTTTCCAC
SLRR1B, PG40 variant A1 , mRNA ACCTGC
Homo sapiens TNF
GGGGGGAGGGAGCTA receptor-associated CTGTGGGATTTTCAAAATGCTAA TTAGAGAAGGATGAGG
6872 11641428 22718605 15230082 TRAF5 MGC 39780, RNF84 NM_004619 factor 5 (TRAF5), ILMNJ 732913 AGACTCACACTGCAGCAATCAT CAGACCATGTACAGTTA transcript variant 1 , CCCAG AA mRNA
Homo sapiens family CACTGGTGGGATATTTT
GACTGCAGGCTCCCCTTCCTGC with sequence GGGATGTCAAGGGGTG
1075 163 94762 12 319529 23 500063 FAM116B MGC33692 NM_001001794 ILMN_1743806 ACCACCATTGTCTCAGCAGTAA similarity 116, member GAGGCAGAGCACAAGT AGGCGA
B (FAMI 16B), mRNA C
Homo sapiens TCCCAGCGGGTGCGG
AGAGTAGATGCTGACCTGGGCA chromosome 16 open GGGGTCCACCAGGCCC
5 539 92 06848 14408596 22 931309 C16ORF45 FLJ32618 NM_033201 ILMN_1660816 CTCCACCATTCCGGGGCACCAC reading frame 45 TTACACACCGGTCTCT AGAGAT (C16orf45), mRNA GCT
Homo sapiens vacuolar protein sorting 41 CTCAGCATTTCCTTATCCCAAGA
2689 55 805008 23 17091 19675726 homolog (S cerevisiae) CTAGTGTGCTTTCTGCTACACT
VPS41 HVPMi' hVPS41 P' NM-014396 (VPS41), transcript GCTAG variant 1, mRNA
Homo sapiens
GGAAGATGCCCCGACT transcription factor 7- CAGTGGAGAAAGCGGTCCTCTG TCTTTGGCCAGTGATG
1096 2202976 26 52577 15382851 TCF7L1 TCF-3, TCF3 NM_031283 like 1 (T-cell specific, ILMNJ 669015 AAATGGTTTCCTCCCAACCCCC GGGAATCAGTGAGTGC
HMG-box) (TCF7L1), GCATTT TC mRNA
Homo sapiens puπnergic receptor GCAGTCTGTTCTTGGCTGGGTC
7 133 137 04762 13435646 27 071133 P2RX4 P2X4R, P2X4 NM_002560 P2X, hgand-gated ion AACTCTGCTTTTCCCGCAACCT channel, 4 (P2RX4), GGGGTT mRNA
Homo sapiens CKLF- likβ MARVEL CTCCTCCAGCTACCGC
ATTTAATCGGTACCCTGCTCCTC transmembrane domain AGAGCCCACAAACCCA
2 352 58 962425 239418 26401073 CMTM7 CKLFSF7, FLJ30992 NM_138410 ILMNJ 713397 CTCATCGCCTCCATTGTGGCAG containing 7 (CMTM7), GGCATCTATCAAAGTC CTTCC transcript variant 1 , CC mRNA
Homo sapiens odd- TGGGCTCTCTCGACAC
CCAAGCACCCCGGGTCTTTACA skipped related 2 GTTGCTCAGCCAGTCA
22 33 3688476 12623283 26 126007 OSR2 FLJ90037 NM_053001 ILMNJ 692163 CAGTCCGCGTCCACAGACTCTG (Drosophila) (OSR2), CTCCTTCCCCTGTGGA ACGAAG mRNA
Fold change XS pOS+βGF pOS Common Synonyms Gβnbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens C1q and
LORD, GTCCTGCTGCTGGCAAGGAATG tumor necrosis factor
2555 512 7476 2767228 14 124338 C1QTNF5 DKFZp586B0621, NM_015645 GGAACAGTGGCTGTCTGCGATC related protein 5
CTRP5 AGGTCT (C1QTNF5), mRNA
Homo sapiens Ras association
GCGCCCCCTTCTTCCAGATGTA
DKFZp781O1747, (RalGDS/AF-6) domain
16 268 1768 17 722754 21 687426 RASSF2 NM 170774 ATAGAAAGCTCTGCCCTATCAC KIAA0168 family member 2 AAGGGG (RASSF2), transcript variant 2, mRNA
Homo sapiens cytidine moπophosphate-N- acetylneuramimc acid CACAGACAAATGGGAT
CACCCAACTGGAAGTCATTCCT hydroxylase (CMP-N- AACACTCATTAATTGGT
9 506 18903513 27986189 15656141 CMAH CSAH NR 002174 ILMN_1812163 GATGTGCTGTGAGCAGAATGGG acetylneuraminate GGGCGATGGCTCGTGT CCTGCG monooxygenase) T (CMAH) on chromosome 6
Homo sapiens
GGCTGAAAGAGGCCAA cytochrome P450, CAGTGTGGATTACACTGTACCT TGCCCCACTGGCAGCA
7018 14408096 16 59635 28 731052 CYP2U1 P450TEC NM 183075 family 2, subfamily U, ILMNJ 781824 TGGGCGGGAGAGTTTGTTCTTG TCTTCACTTCTAAATGC polypeptide 1 ATATGG A (CYP2U1), mRNA
CAGTGAGCCTTCGCAG C
Homo sapiens TBC 1 ACATCAACGAGCTGACTATGAA
ATGCTGGAGATCCTGG
6 887 158 18929 18014797 2950241 TBC1D17 FLJ12168 NM 024682 domain family, member ILMN_1760245 GCTGAGCGTGGAGGACGTGCT
GGTTGGTCTGCTTTGT 17 (TBC1D17), mRNA GACCCGC
GT
GACCGGAAGCAACCCC
Homo sapiens reticulon CGTGGCTAGGCCTTTCCTGCCG
TTCACAGACACGAGCA
5937 115 189285 12 80694 29590256 RTN 1 NSP, MGC133250 NM_021136 1 (RTN1), transcript ILMNJ 745994 AGTGCTCTGATGCAATAGTGGA
CATCGGCAAACCCTAT variant 1 , mRNA AATCGC
GA
Homo sapiens complement
ACCCCCCGTGAGGACTAATCCA component 1 , s
54 11 1088906 14 77713 29676437 C1S NM 001734 GATACATCCCACCAGCCTCTCC subcomponent (C1S), AAGGGT transcript variant 1 , mRNA
Homo sapiens activating transcription CTCCCAGCGTTAACACAAAATC
5609 12246011 29764801 1728556 ATF3 NM 001040619 factor 3 (ATF3), CATGGGCAGTATGATGGCAGGT transcript variant 4, CCTCTG mRNA
Homo sapiens klotho TCCACCACAGGAATGTATCACA
1686 227 2351 62385783 30364079 KL NM 153683 (KL), transcript variant ACTTAACCGTTCCCGTTTGTTAG 2, mRNA ACTAG
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequeπce_l CCCAGGTCGGCCCCTG
Homo sapiens GGCACTGTAACGTACCAACGTA
GAGACTCTGGTTTTTAA
5971 15866428 28889027 24 773756 ADAMTSL5 THSD6 NM 213604 ADAMTS-like 5 ILMN 1804884 CCAATTTCCCCTTTTCCCCTGG
GAAATGCACACAGCTA (ADAMTSL5), mRNA CTACCA C
Homo sapiens
TCAGACCAAGGGCTCC
DKFZP586C1522, hematopoietic cell GGGCTGACCCTCCTGCAGCTTG
AAGGAAATACTGCCCA
5899 11396428 12609679 30544498 HCST DAP10, PIK3AP, NM 001007469 signal transducer ILMN 1768979 GACCTTTGACTTCTGACCCTCT
CGTCTAGTGCAGGAGC KAP10 (HCST), transcript CATCCT AG variant 2, mRNA
FLJ00032, KR18, Homo sapiens zinc
TGGGAGCCCAGAAGAA TGGAGATCATTCCATTACACTCC DKFZp686B16128, finger protein 160
4 804 111 243454 24612354 23627666 ZNF160 NM 198893 ATGCTCTTTTGCTTGGA ILMNJI 724533 AGCCTGGGCACCAGGAACGAAA KIAA1611. F11, (ZNF160), transcript GTTTGTCATCCTACACC CTCGT HZF5, HKr18 variant 2, mRNA
Homo sapiens membrane-associated TGTGCCACACGGAGTTTGCAGT
HSPC240, RNF172,
3343 7801481 17372307 3180603 Mar-02 NM 001005415 ring finger (C3HC4) 2 GGAGAAACGGCCTCGACCCCTC MARCH-II (MARCH2), transcript ACAGAG variant 2, mRNA
CACACTGCTGGGACAT Homo sapiens euαne GGCAGGGACTTCACAG CGCCTGATCTTTGAAAACACTAC
11 75 2668393 16293777 31 814331 LRRC32 GARP, D11 S833E NM_005512 ILMNJ654112 ACAGGGCTGCTGTCACTTCCCA
» JKSS TGGGGGTTTTTAGCTG GGGCC
GC
Homo sapiens protein phosphatase 1 , ATGGCCGCTGCCAGCCCAGAC p53BP2-lιke, p85,
2273 59810417 28253895 25317493 PPP1R13B NM 015316 regulatory (inhibitor) GCTGCTGACGCTGTGTAAATGT KIAA0771. ASPP1 subunit 13B GCACAAT (PPP1R13B), mRNA
Homo sapiens rhomboid 5 homolog 2 TGCTCGAGGCGCATCAGGCCC
RHBDL6, RHBDL5,
2 828 7245819 29512218 23285923 RHBDF2 NM 001005498 (Drosophila) G M I I I IACCAGTTTATATCACG FLJ22341 (RHBDF2), transcript GTCTTC variant 2, mRNA
Homo sapiens AGGAGAAGATGCCTCTGGAGTT
4071 11727678 32026337 25875755 CBLN3 PRO1486 NM 001039771 cerebellin 3 precursor TGGATCGGGTGTTACAGGTACA (CBLN3), mRNA AGTAGG
Homo sapiens sterile CTGTGCCCCCTGATTT
AGCTGTGTGACCGGGAGTAGTC
SAMD2, FLJ36296, alpha and TIR motif GAGGGTAAGAAGTAGA
8288 23262262 26618277 2974316 SARM1 NM 015077 ILMNJ 748474 ACTTAACCTATGTCTCCCCTTCC KIAA0524, SARM containing 1 (SARM1), TAATGAGGCCACTGTG TCACC mRNA GG
Homo sapiens acyl- CCTGGGCTCAAGCAGT
PTE1, hTE, TGCTGCTCAGGAGGTCCCCATT CoA thioesterase 8 CCTTCTGCCTTAGCCT
321 8557266 22355888 32948074 ACOT8 HNAACTE, PTE-2, NM 005469 ILMNJ665550 GAGATCAAGCCAGTAAACCCAT (ACOT8), transcript CCTAAGTAGCTGAGAC PTE2, hACTE-lll CCCCCC variant 1 , mRNA TA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe Sequeπce l
Homo sapiens protein phosphatase 1 , CTAACTTGCTCTGTGAC TCTCCCTGCCCCCCGGACGCC
CPI-17, CPI17,
9802 22982678 2508123 25399117 PPP1R14A NM 033256 regulatory (inhibitor) TTTGACCAAGTCATTTG ILMNJ 738536 GCCCAGCTTGCTTGTGTATAAG PPP1INL subunit 14A ACCTCTCTGGGCCCCA TTGTATT (PPP1R14A), mRNA
GCCCAGTTTTCTCTGG
Homo sapiens CCACCGCTCTTCGGGCGGCAG
TGGGTCCAGTGTTTTG
2736 73449295 27 890568 27698284 TMEM91 FLJ27310 NM_001042595 transmembrane protein ILMN 1660732 CAACCTGAGATTAAACACCAGA
TTCCTAGGTGTCTGCT 91 (TMEM91), mRNA CACCCTT
GC
GCTGAAGTGCTCACGG
Homo sapiens integnn, TGATAATGCCCCAAGGACAAGG
CTCACTGCAGTTTCAA
2862 46499344 15042843 27 307652 ITGA11 HST18964 NM 001004439 alpha 11 (ITGA11), ILMN 1763765 GGCGTGCCTGGCGCCCAGTGG
GTTCCTGGGCTCAAAG mRNA AGTAATT
AT
Homo sapiens
TGTCACACCTGCTGCCCTACTT transmembrane 7
4 784 11776012 26805578 26301428 TM7SF2 ANG1. DHCR14A NM_003273 CTACCTCCTCTACTTCACCGCG superfamily member 2 CTGCTG (TM7SF2), mRNA Homo sapiens acyl- Coenzyme A GTTTTCCCGTTTTATGT AGGACCTGGGCGCCTGGGAAA
3024 81 65616 30 550749 25 995897 ACAD10 MGC5601 NM_025247 dehydrogenase family, GGGCAATAATGTCAAAT ILMN_1654583 ATGGAATGCAACCCACATTGTA member 10 (ACADIO), GTGCTATGCAGCCAGG AAGCCAC mRNA
Homo sapiens cytochrome P450, family 27, subfamily A,
GGAGACGGGGGAGTTGAAGAG polypeptide 1
7453 2069226 22614029 36453587 CYP27A1 CYP27, CTX, CP27 NM_000784 TGTGGCCCGCATTGTCCTGGTT (CYP27A1), nuclear CCCAATA gene encoding mitochondrial protein, mRNA
Homo sapiens zinc CTCAGCACACACTGCC GGAAAGACGTGCCAGTTGTGGA
2682 8878516 32 85228 33 7026 ZNF425 MGC150568 NM_001001661 finger protein 425 AGTCTTCCCCAATATCT ILMNJ 772798 GGAAACATTCACACTGATCTGC (ZNF425), mRNA GTCTCCTCTCAATTCCC TAGTCC
Homo sapiens TCCAGAATTCCTCCTTC
TGTGACACCACGCCAGATCACA
FLJ20515, slingshot homolog 3 TTGGTGTGTCTGGAGG
12 52 24509763 10877688 3687484 SSH3 NM 017857 ILMN 1672635 GGGCACCAGGCCAGAGATAGT FU10928, SSH-3 (Drosophila) (SSH3), GTGGGCAAGGCTGGG CTTCTTT mRNA AG
Homo sapiens
CCTTCTGGGTGGAGGC TGGATCAAGGAAGGCTGCCCCT chromosome 9 open
2873 850602 28 811693 32 012035 C9ORF7 D9S2135 NM 017586 TTTCCGACTCCCAATCA ILMNJ 746632 GTACCCTGTGGGGAAATGGTGG reading frame 7 TGAAGGCAAGTTAATCT GTGCAT (C9orf7), mRNA Homo sapiens CAAGGGGTATTACTCAGGCACT
MGC119564, TSP3,
1005 2767393 20744036 37 367134 THBS3 NM 007112 thrombospondin 3 AACCCCAGGAAAGATGACAGCA MGC119565 (THBS3), mRNA CATTGC Homo sapiens
CTGAGAACTCCAAGTCTGTGAG
MGC71151, PASD4, neuronal PAS domain
5486 12802261 15996029 37 528507 NPAS2 NM 002518 GGGAGAGGTTTTACAAGCCAGA M0P4, FLJ23138 protein 2 (NPAS2), CAGGCC mRNA
Fold change XS pOS+βGF pOS Common Synonyms Gβnbank Description Probe Sequθnce Probejd Probe_Sequence_l
Homo sapiens
MGC4307, GCACACAGCTGGCACC oxysterol binding GGTTGCAAGCTGAGAACATCCA KIAA0772, ORP2, TTCTCCTTATCCTACTG
3015 90 5268 37 81977 23868866 0SBPL2 NM 144498 protein-like 2 ILMN_1656724 GAGGTGAGACTCAGACACATTG MGC8342, TGGGTCCAACATGGTC (0SBPL2), transcript AAAGTG FLJ20223, ORP-2 C variant 2, mRNA Homo saptens phospholysine
GTATTGGTGGATCCAG
MGC142189, phosphohistidine CCAAGGCACACAGGGTACTTTC GGATAAATCCCAAACTT
6641 21046011 34 39969 3088544 LHPP MGC142191, NM 022126 inorganic ILMNJ714738 TGGACCCACTGCTGGACAGACT CTTAACCCCTAGACCG MGC117251 pyrophosphate TGAAGG G phosphatase (LHPP), mRNA
FLJ37451, Homo sapiens CTGACATGAGTCCAGG glycerophosphodiester GAGAGGCAAGATTGAG AGACTATTGGATACATTTGGCAT MGC35046,
2446 89 122635 35859634 37476196 GDPD1 NM 182569 phosphodiesterase ILMNJ 804870 TGGGCTGAGTGTGGTGGCTCAT FLJ27503, GDE4, CAATAGTCAGTGGCAC domain containing 1 GCCTG UGPQ CA (GDPD1), mRNA
Homo sapiens
TTTTCCTGGCCACAGA spermatogenesis GGCACAGGTAGCTCAGTTTATT GAGATCCACGTGCTGG
6993 17843927 28587152 28439234 SPATA18 FLJ32906 NM 145263 associated 18 homolog ILMN_1761917 TGCTtTCTACCCTGCCTGGCCA ACACCGACTACGAGGG (rat) (SPATA18), CTTGCT CT mRNA
GGGCC I I I I I GGTGTT
Homo sapiens TGACCAGTAACCACCTTCCTTCA
RP11-227F8 1, GAAGGGAATCAAACTA
11 81 26988928 28070717 25 533855 OLFML2B NM 015441 olfactomedin-like 2B ILMNJ 737320 AGCCTTCAGCCCCTCCAGCTCC MGC51337 CATTTGCTGCTTGTGT (0LFML2B), mRNA AAGTC GC
Homo sapiens solute
GGATGGGGAGGATGGT
FATP1, ACSVL5, earner family 27 (fatty CAGACATCCCTACTGGCTTCGC TGCACAACAGTGTGAG
7 858 2708976 30451405 40298264 SLC27A1 FU00336, NM 198580 acid transporter), ILMNJ688104 TGGTGGCTCATCTCGAACATCC TGTACTTAATGCCACTG MGC71751, FATP member 1 (SLC27A1), ACGCCA C mRNA
Homo sapiens tumor CTAAGAAGGGAACTTG
CCCGCTGGGAAAAACCCAGGCC
D53, MGC8556, protein D52-lιke 1 CCATCAAGATTCCTGTA
2022 4832351 14 831423 42 019188 TPD52L1 NM 001003396 ILMNJ 788315 TTGACATTGTTATTCAAATGGCC hD53, TPD52L2 (TPD52L1), transcript CCAGGCCCACGGCCGT CCTCC variant 3, mRNA C
Homo sapiens GGCCCAGCATGGCTCA
ATTTGTACCGAAACACCCCGCT superoxide dismutase CCTGTCCCGTGGGCTG
107 263 93097 14629435 4367214 SOD3 MGC20077, EC-SOD NM_003102 ILMNJ663080 CACGCTGACAGCCTCCTAGGCT 3, extracellular (SOD3), TGTTTCTTGTTGTTTTT CCCTGA mRNA C
Homo sapiens
CTGTTCTGCTGGGGACCCTCGT hypothetical protein
4875 17091428 31 700298 4057979 L0C652968 NM 001037666 TCCGCTCTCTGTATGTAAGCTG LOC652968 CGTGCA (LOC652968), mRNA
Homo sapiens AGAAAGTCCCTGGTCA
TATGCAGGTGACTGTGTTTGAC
ASMTU, ASTML, acetylserotonin O- GGTCTCAGGTAGTGCG
4 327 152 30594 28618969 44034157 ASMTL NM 004192 ILMNJ 696284 CTCCCAGACATTATCGAGCTGG ASMTLY methyltransferase-like GTGTGGCTCAGCTGGG CCGCCC (ASMTL), mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbaπk Description Probβ_Sequence Probe_ld Probe_Sequence_l
CD339, AWS, HJ1, TGTGGAAGGGGCCTCT
Homo sapiens jagged 1 CTGCCACCCTGCTGAGTCTGTT
GGGTGGCAGCTCTGG
23 11 667 97266 44 124336 20285776 (Alagillθ syndrome) CTGGTAATCGGGGTATAATAGG
JAG1 MGC104644, AGS. NM-°°°214 GCTTTTGGGTGTTGGA (JAG1), mRNA CTCTGC
AHD CAA
Homo sapiens GCTGCGTTTAAGCCTT
FLJ10332, TGACCCAAGGGCCAGCATGGG cryptochrome 2 CCCCCATCGTGTACTG
2 741 96 58513 3629148 36 51824 CRY2 KIAA0658, PHLL2, NM_021117 AAAA (photolyase-like) CAGAGTTGAGCTGGCA GAAGAGATGGTTGCAGGC
HCRY2 TGCACTT (CRY2), mRNA GG
CGGTGCAGGCTTCCTG
Homo sapiens TCTGCCCCAGGCCCTACTACCC
GATGACAGTTGGGTGA
2038 8366022 43581738 389263 PLD2 NM 002663 phospholipase D2
TATGTGTCATGTGGCC ILMN-1660841 ATTGTTCCCTTCCTCTTCCTGCC (PLD2), mRNA CTTGA
TA
Homo sapiens pleckstrin homology
TGGGCCAGGACTGCTCTGAGAT domain containing,
3824 167 84763 4088865 47202198 PLEKHH3 FLJ21019 NM 024927 TTGAGGGAAACATGGACCCTTT family H (with MyTH4
TGGCCC domain) member 3 (PLEKHH3), mRNA
Homo saptens
CCAGCCCTGCGTTTCCATTCTG hypothetical protein
3785 12941428 24850315 47 346428 FU20489 NM_017842 CCTTCTCAGAGTGCCCTTGCTG
FLJ20489 (FLJ20489), CACCCA mRNA
Homo sapiens placenta CAGACACATGGCTGTGCAACGC
27 22 672 1018 13 574909 47 503815 PLAC9 MGC104710 NM_001012973 specific 9 (PLAC9), CGTCTAGATGTCATGGAGGAGA mRNA TGGTAG
Homo sapiens calcium
GGTTCCTCTTTCTGTTCCCCCAT binding and coiled-coil
7 08 22655179 43024178 27401142 — ocoi SSSSSTS NM-020898 TGACTTCTGTGCCCCACCCTAG domain 1 CCTTT (CALCOC01), mRNA
CGTGGGGAGAGGGCG
Homo sapiens TCAAAGCAAGAAGGGAGCGCTG - u , ,- -. .. TAAATTGTCTTGTGAAT .-,„..-,
3557 161 81429 4292425 48667336 PLCD3 MGC71172 NMJ33373 ssssr AGGCATGAAGCCCTGGGGAAAC ΪΓGC™ CCMMC TGGCAG
Homo sapiens
GCATGAGGAACCAGTT chromosome 5 open GAGTCTTGTGGGCTCAGAAGTA GACATGCTGGGTTGTG
2457 108 76428 43305183 46241035 —3 SSI8' reading frame 33 ILMN 1690963 AATTCTGTGAAAGCTGGACGGA ACTGGCAGCTTTAGCA (C5orf33), transcript TAGTCG GC variant 2, mRNA
Homo sapiens ankyrin GACCTACCAGGGACM repeat and BTB (POZ) TCGAGGACCTGCTCGTGTCCAT
GCAGGTAAGAGCTGAT
5448 211 04346 50 118958 30000599 «™ ^"S*."*-™ domain containing 1 ILMN_1719433 CGGTCTGGACTGTTGAGCCCCT GTGAGTGTGTGTGATG (ABTB1 ), transcript GGCTGG GG variant 3, mRNA
Homo sapiens inturned GGTGACGATCAGGCCC
INT, PDZD6, planar cell polarity TGGGCCCCCCTGCATC ACCTTGTAGCTGTGCTTTCTTGA
2 818 112 34761 42 170662 4007399 INTU KIAA1284, NM 015693 effector homolog ILMNJ811652 TGCGTAGAAACACGTGCATGGA
TTTTATAGCAGTGGGT FU41326, PDZK6 (Drosophila) (INTU), GGATC GT mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probβ Sequencβ Probejd Probe Sequence l
Homo sapiens ras GCAGACAAAACCTCTT
ARHJ, TCL, GCATGTTTCTACCAAAGCTATTA homolog gene family, GAAACCCTTCCCCCAT
6636 199 78513 42 292854 26857582 RHOJ RASL7B, FLJ14445, NM_020663 ILMN_1657129 GAACCAACACGTACCTCTGAAT member J (RHOJ), GGCACAAACTCGCCCA
TC10B, MGC34777 GCCCG mRNA TG
Homo sapiens dystrophia myotonica- TCCGACTCGCTGACAGGCTACA
953 33072678 40768097 33457928 DMPK
Figure imgf000125_0001
^~ protein kinase (DMPK), GGACCCCCAACAACCCCAATCC transcript variant 4, ACGTTT mRNA
H2BFQ, MGC119804, GAACAAAGTCTCTGGG
Homo sapiens histone CACTTACCACCTCATTTGCTTTT MGC129733, H2B/q, TCACGTTTTGCCTCATG
5 375 17656429 30 811539 41 76604 HIST2H2BE cluster 2, H2be ILMNJ 797531 CTGGAGGCCATGCAATATAGGC GL105, MGC129734, - AACACTGGCTGCAAGT (HIST2H2BE), mRNA GGGAC H2B. MGC119802, G H2B 1
Homo sapiens superoxide dismutase
GTGTCCAGTATGGCTT 2, mitochondrial TACGACTACGGCGCCCTGGAAC
MNSOD, IPO-B, Mn- TCCAGGCTAATCACTTA ,
3634 154 51428 37299747 50 115944 S0D2 NM.001024466 (S0D2), nuclear gene GGGCAGAGACCCAGCC ILMNJ 747047 CTCACATCAACGCGCAGATCAT SOD encoding mitochondrial GCAGCT protein, transcript variant 3, mRNA
Homo sapiens enabled
CCCCACCACTACCTCC CTGGCCCTGTCACTGTGGTGGA homolog (Drosophila)
8931 345 1101 3896357 41 88762 ENAH NDPP1. MENA NM_018212 ATGGTTGTTCATTTAGG ILMNJ 689059 TCAGTGGACCTGCTGAAGTCAC (ENAH), transcript ATGCTTCTAATTCAGCC TGGACT variant 2, mRNA
AGGAGGGCCTGGGTTTGGGTT
Homo sapiens myosin
8859 3826726 48 843613 3967196 MYO1D KIAA0727, myr4 NM_015194 CTTTCCTCCCAGCCTTTGGATG ID (MYOID)1 mRNA GTGCCTT
Homo sapiens SH3-
FLJ43054, domain GRB2-lιkβ ACTCTCAGTTGGCCCCCTACAG
3 16 142 85596 39241722 52 72283 (endophilm) interacting CAGTCTGGTGTTGAAGTTTCTTT protein 1 (SGIP1), GAACG DKFZp686A16142 mRNA
INCAM-100, Homo sapiens vascular ATGGATCCCAACTTCTC
TTCACGAAGTTTGTTCATCAGAC cell adhesion molecule CCCGGCAGCTCTGCCT
154 5 27440977 70687838 5323925 «™ DK6F0S2333, NM-°°1078 ILMN 1798624 TCCTGTGCAACTTTCCCAATGT 1 (VCAM1), transcript CCCTAAGTCTGTGAAG
GGCCT
CD106 variant 1 , mRNA C
Homo sapiens TBC1 AGCTGCTGTTGCCATC dJ130H162, GGCAGCTAAGGCCTCCAGGGC domain family, member TTGAACAACTCACCAAC 17388I9
2 723 12022261 38860733 5206681 TBC1D10A TBC1D10, NM_031937 GGGGTCTCCATATAACTACACG
10A (TBC1D10A), CTCCAACCCAGAGCCC "-1^"-1 "0015* dJ130H16 1, EPI64 GTTCATG mRNA C
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequθπce Probβjd Probe_Sequence_l
BBS2L2,
MGC51114, Homo sapiens Bardet- CTCCCATTCTCTAGTACTGCTCC
3973 20528928 56788776 47 137867 BBS1 FLJ23590, NM 024649 Btedl syndrome 1 CCTACCCAGCAGTCACTTCCAG
MGC126184, (BBS1), mRNA TTCAT
MGC126183
Homo sapiens zinc
GGGTCCTAGTTGCTTGGGTTGG
FLJ14451, finger CCCH-type
2445 11782678 4658336 51 097603 ZC3H10 NM 032786 ACAATACAGGAATTGCTTCTGG ZC3HDC10 containing 10 GCCCTG (ZC3H10), mRNA
TGGATGCCCAGGGGAA
Homo sapiens dual GCCAGGCCTATGTTGGAGGGA
JSP1, JKAP, MKPX, GGCATACAGGCCTCAT
2411 11576428 40753162 57 77529 DUSP22 NM 020185 specificity phosphatase ILMNJI 737819 GTTAAATACCTGTGCATCCCAG VHX CCACCAGGCAATAGAC 22 (DUSP22), mRNA CAGCGGA AG
Homo sapiens
CCGGTTCTGGGGCGAA phosphodiesterase 1C, GACCTGGCTTTCAAGGCATCTG AATGCCTGCCCTTCAC
6 113 218 80179 25964321 57 560844 PDE1C Hcam3 NM 005020 calmodulin-dependent ILMN_1782419 TCTGGCCTGATGAGAATGGACA
ATCGAAGATTTGCCAG 7OkDa (PDEIC), TCCTGG
AG mRNA
GCTATGAGTTTGTGCC
Homo sapiens TCCGAAAGGCAGACCTCTGAGC TTTGCTGAGGACACTA
3074 13941013 3746571 57 731255 DOCK6 ZIR1 NM 020812 dedicator of cytokinesis ILMNJ 797731 CCACAAGGACCAAAGCTGTACC GAACCTGGCTTGCCTC 6 (DOCK6), mRNA TAGAGG CC
Homo sapiens
ACCTGAGCGCCCCCGTTACCTT mannosidase, alpha,
422 191 36429 40603954 54 822678 MAN2B1 LAMAN, MANB NM_000528 GAACTTGAGGGACCTGTTCTCC class 2B, member 1 ACCTTC (MAN2B1), mRNA Homo sapiens GAAGGATACTGGTCTG
GGTCCCAGCCAGGCACACACAA
C90RF3, APO, chromosome 9 open GATTTGGTTGCTGATG
4472 206 16013 4299923 5220766 C9ORF3 NM 032823 ILMNJI667907 AAGGCAGATTCTCGTAAACGCA FLJ14675, AP-O reading frame 3 CTCTGGGGGCAGGAGT GCCTCC (C9orf3), mRNA AG
Homo sapiens trophinin TCCCCATGTTTACAGATACCGCT
KIAA1114, MAGE-
6 131 304 56845 4990547 50961853 TRO NM 001039705 (TRO), transcript AATAAATTGCAGTAGTCCTTCCC d3, MAGED3 variant 6, mRNA ATGG
Homo sapiens elastin (supravalvutar aortic
FLJ38671, SVAS, ACCCAAGCACCTGAAGCCTCAA stenosis, Williams-
1547 5630851 23440025 59470417 ELN WS, FLJ43523, NM_001081754 AGCTGGATTCGCTCTAGCATCC Beuren syndrome)
WBS CTCCTC (ELN), transcript variant 4, mRNA Homo sapiens methionine sulfoxide TCACAGTGATGTCTGCATTCAAC
FLJ36866,
4919 23674762 4727073 51 247543 MSRB3 NM 001031679 reductase B3 (MSRB3), CTGCTGCATTTGGTGACAAAGA DKFZp686C1178 transcript variant 2, GCCAG mRNA
Homo sapiens GRB2- associated binding CGAGGGGGTCCCCAAGAGATC
2937 14884344 4988272 53 177002 GAB2 KIAA0571 NM 080491 protein 2 (GAB2), CAGGCTGTCATGTGATTTATGG transcript variant 1 , TGGCATG mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbaπk Description Probe_Sequence Probe_ld Probe_Sequence_l
Homo sapiens
GAGAAGGAATCTGGACTCCCCA hypothetical protein
377 19869762 57 373505 4947748 FU11286 FLJ40743 NM_018381 TCCCCCCACCAGGATAAAAGTC FLJ11286 (FLJ11286), CTGACC mRNA
Homo sapiens transient
GTGTCAGAGGACCTTG receptor potential GTCCTTGGGGTAACAGGGACCA ACTGGGTTCATTTTATG
5511 2967393 51 76651 5696234 TRPIVM FLJ20041. TRPM4B NM 017636 cation channel, ILMNJ 669142 CAGACCCCTCACCACTCACAGA TCCAGACATCACCCCT subfamily M, member 4 TTCCTC G (TRPM4), mRNA
Homo sapiens mucin 1 ,
PEMT, PUM, PEM, TAGCGGGGATCCTGAACTGGAC cell surface associated
8455 4599226 6396224 45615658 MUC1 EMA, H23AG, NM 001044391 TGAATAAAACGTGGTCTCCCAC (MUC1), transcript MAM6, CD227 TGCGCC variant 6, mRNA
Homo sapiens p8
AGCTGCAGAATTCAGAGAGGAA protein (candidate of
284 11938059 5648385 35 517784 P8 C0M1 NM 012385 GAAGCGAGGGGCACGGCGCTG metastasis 1) (P8), AGACAGA mRNA
Homo sapiens catenin, beta interacting protein GAGCCCACCTTTCTTCT AGTCAGGTGTCGAGGCCACATT
2 568 141 32262 503254 61 736164 CTNNBIP1 MGC15093, ICAT NM_020248 1 (CTNNBIP1), I I I I I GCTATTAGATGG ILMNJ 678684 GCTGGCTGCCCCCTCTTTGTAG transcript variant 1 , GCTTGCTGCTCCCGCC CTCCTA mRNA
Homo sapiens
TGAGCATCCTGGAACAGGCGGC glutathione S-
2 105 121 930954 6595953 5096361 GSTT2 NM_001080843 CAAGAAAACCCTCCCAACACCC transferase theta 2
TCACCA (GSTT2), mRNA
CMT1A, GAS-3, Homo sapiens
ATTTCACTGTGGATATC
DSS, CMT1E, peripheral myelin CCAACGCACCCGAGTTTGTGTT CCTGAGGCCATGAGGG
5487 24857262 49 80632 47 89319 PMP22 MGC20769, NM_153321 protein 22 (PMP22), ILMN 1716999 TGAGGCCACCCTGAGGATCGG TGGGAGCCGGCCTGG
HMSNIA, HNPP, transcript variant 2, GACAGCT GC
Sp110 mRNA
Homo sapiens adaptor- AGCAGCAGAGCGTGCC
TGCACCCCACAATGTCTGCGGC
CLAPA2, HYPJ, related protein complex AGCCGCAGTGTTTGGG
2658 15061429 51 421036 63896503 AP2A2 NM 012305 TCTTCTTCCGGCGTGTCGGGCT HIP9, ADTAB 2, alpha 2 subunit AGCCTGAAGGAAGACT "-MN-U n u0' TTGATC
(AP2A2), mRNA GA
TGCTGTACTGTGAGCC shootini , shootιn-1 , TTGCACGTGTGGTAAGCATAGG
2 248 134 75595 53 179333 6848308 KIAA1598 MGC40476, NMJ318330 K=^598,, SSSSE5 -J668683 CTTGAAGAGGTGGGTAGGCAG
DKFZp686A0439 mRNA GTACATG
Homo sapiens protein
TAACCAGGAAGGCCAA argmiπθ GACTGGAAGATGCAGACCTTGG
HRMT1L1, CAGCTCAGGAGAAGCC
2 595 163 59344 69 54125 5788778 PRMT2 NM 206962 mθthyltransferase 2 ILMN 1714522 TTCCTGTTAGTGGAAACACTGTA MGC111373 ATGTCACTGGGGAGCC (PRMT2), transcript AGGTC AC variant 1 , mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe_Sequeπce Probe Id Probe_Sequence_l
Homo sapiens aldehyde dehydrogenase 4
GGATAATCACCCCCTT
P5CDh, P5CD, family, member A1 GTTCTACTGGTTCTACACTGTGA CATAGTCTTCAGGCTG
4095 22273929 42 153183 7042 ALDH4A1 ALDH4, P5CDhL, NM 170726 (ALDH4A1), nuclear ILMNJ 675597 GGTGGCAATGGGATTTGCTCAG AGGGAGGTCTGGCAAG P5CDhS gene encoding ATGCC CC mitochondrial protein, transcript variant P5CDhS, mRNA ccccTTTGACAAGCTT
CSP2, ZAKI-4, Homo sapiens AGTGTTGCAAGGGAACCTCCTA
CCATAGTCTTCAGACAC
13 1 482 53094 33741356 56241808 RCAN2 MCIP2, hRCN2, NM_005822 regulator of calcinβuπr ILMN_1721292 GCACTGTGAAAGTCAGAATCGC
GCACATTGATGGCATC
DSCR1L1. RCN2 2 (RCAN2), mRNA CTCAGC
C hT T G GGGGACAATGAAGACAAGCACA CGTGCAACCCCCTCT ILMN
5 757 285 10178 47 967438 5943971 ITGBL1 OSCP, TIED NM 004791 beta-fli-kTe 1 (with ESGϊF"- 1 A GACGTAGGTTCTTTGT 1728049 CAGGAGGTAGAATATCAGAGTG like repeat domains)
TTCAGTCTCATCTAACC GGGCTG
(ITGBL1), mRNA
Homo sapiens
GTGTCACTGTTGGTTGGAGGAC
HS984G1A, C22orf3, rhomboid domain
2 074 1442351 6948305 6964098 RHBDD3 NM 012265 AAGTGGGCACTGAGACCCTGGT PTAG containing 3 GACCCA (RHBDD3), mRNA Homo sapiens
CTGTTGAGAACTTTTAC
CENTB6, ACAP4, development and GTGGTTCCCACAGGAACAGGGT ACTCTGGTGATAAGCA
7 818 317 10596 22 856537 7243669 DDEFL1 FLJ20199, UPLC1, NMJ317707 differentiation ILMN 1683942 TGTCTTTTGAGCCCCCAGTGTC CGGCCCTGGACCGGG
ASAP3 enhancing factor-like 1 TGGTTT AG (DDEFL1), mRNA Homo sapiens polycystic kidney
TAGGTGTGGTGGCGTTATGGCA disease 1 (autosomal
4661 312 53928 67 03815 67 72975 PKD1 PBP NM 001009944 GCCCGGCTGCTGCTTGGATGC dominant) (PKD1),
GAGCTTG transcript variant 1 , mRNA
GGATTGCTGGTGTCCA
PGII, DSPG2, Homo sapiens decorin GCTTTGGGAGCAGAGAAGAGG
GCATGACCCATAAACA
1586 795 1643 42 36229 6905347 DCN CSCD, PGS2, NM_133503 (DCN), transcript ILMN_1741613 GAGAAAGCAGCATCTTGCCTGG
GGTCAGAAGAATGATG
SLRR1B, PG40 variant A2, mRNA ATGAGCC GA
FLJ12979, Homo sapiens WD
FLJ14217, repeat domain,
GGAACCTGGAGTCAAAAAGAAC
DKFZP434J154, phosphomositidθ
2 561 157 06427 7062503 5588077 WIPI2 TGCTTCAGTCCCCGCTGTACCG
DKFZp686P02188, "^1-" 10""-3 interacting 2 (WIPI2), CCTGCC
Atg21, WIPI-2, CGI- transcript variant 2,
50, FLJ42984 mRNA
Fold change XS pOS+6GF pOS Common Synonyms Gβnbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens aldehyde TAAGGCCCTGCACTGA
GCAAGCTTCCTCCCTCAGCCAT
ALDHI, MGC1806, dehydrogenase 2
4 026 262 38095 6967496 61 721268 ALDH2 NM 000690 TGATGGAAAGTTCAGCAAGATC ALDM, ALDH-E2 family (mitochondrial) £S£S££ ILMN-1653026
(ALDH2), nuclear gene _ AGCAAC encoding mitochondrial protein, mRNA
.„ . , GGCACCGTGTCCAAGT Homo sapiens IQ mot,f ππ^cccπc™ ACTGTCCCCTTTAGAGATCCCA
2 547 157 1518 7525716 52 194458 IQSEC1 KIAA0763 NM 014869 and Sec7 domain 1 ILMN 1780036 CCTGTCAGAGCCACAGCTTCGG
GCCAGACCGAGGTGTC (IQSEC1), mRNA GGTCCT C
Homo sapiens motile
CTGGGAAAGTGCTCGA sperm domain TCTTCTTGCTGACGGGGATTGT CTGAGACCTTGGGAGT
2 465 167 78928 67 02692 7028679 MOSPD3 CDS3 NM 001040097 containing 3 ILMN 1759848 GTCTGTGGCCTTCCTGCTGCTC CTTGGGAAGTCCAATG (MOSPD3), transcript CCACTC GG variant 2, mRNA
Homo sapiens lιn-7 CTGTTGTCGGTGAACGGTGTGA
LIN-7B, MALS-2,
2447 15051845 76448166 49482178 LIN7B NM 022165 homolog B (C elegans) GCGTTGAGGGTGAGCAGCATGA VELI2 (LIN7B), mRNA GAAGGC
Homo sapiens SIN3 homolog B, CTAAGAAGGGAACTTGCCATCA
2721 17479762 76 540665 55529587 SIN3B KIAA0700 NM 015260 transcription regulator AGATTCCTGTACCAGGCCCACG (yeast) (SIN3B), GCCGTC mRNA
Homo sapiens PTPRF
GTGGGAAAACTATAAA interacting protein, CCACAGTCTTGGCTGAGATCAA
CcIpI, MGC42541,
8 131 49598926 71 49109 54 894814 PPFIBP2 NM 003621 DKFZp781K06126 bindmg protein 2 (hpπn
Figure imgf000129_0001
AGGGATGAGCAACAGGGACTTC beta 2) (PPFIBP2), TGCCAC mRNA
Homo sapiens TCGACGGTGATTTGCA
GAGTAGTCCCACGCTGTTGTTG
SSH-1. FLJ38102, slingshot homolog 1 GGTGGAGAGTGCTGG
4433 26687262 7042941 56 191177 SSH1 NM 018984 ILMN 1730379 AGCTGACTCTGTGCCCGAATGG KIAA1298 (Drosophιla) (SSH1), GATGGAAGGCCGGGAT TGGTGC mRNA ACT
Homo sapiens deoxvuridine GCAAGAGGGACAGGAG triphosphatase (DUT), CCCAGAAGAGACACTG AAATGACTCCCCTCTGCCCTCG
2 325 16428928 67 259575 75086975 DUT dUTPase, FLJ20622 NM_001025248 nuclear gene encoding AGGACAAGAGATCACA ILMN.1740903 CCCCGCGCTCTGCTACCATTTC mitochondrial protein, CTTACG transcript variant 1 , mRNA
Homo sapiens RNA GAGCGAGATATGCTCA
CTACCTTGGGGGAATGCCGTTG
MGC20460, PRR8, binding motif protein 33 GAGAGGAGCTGGCTGA 1749239
2 388 15348096 79 354774 53 128277 RBM33 NM 001008408 CCTGTTCCACCCCTTTGTTCACT DKFZp434D1319 (RBM33), transcript CCTGCAGGAGACAGTG ILMN-η 'w∞ TCGCG variant 1, mRNA AA
Fold change XS pOS+6GF pOS Common Synonyms Gβnbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens tubby
CCTAGAACGCAACTTAGGATGG homolog (mouse)
2473 164 56012 62344383 73 33541 TUB rd5 NM_177972 CTAGGAAAGGGAAGCCTGACTG (TUB), transcript CTCGGT variant 2, mRNA Homo sapiens GAGCGCTATGCCACCG
GTGGAGGCCTGGTTTCTGGGTA adenylate cyclase 6 AAGCGTTGACCTGAAC
3648 2592726 63360695 80 16894 ADCY6 DKFZψ779F075 ATGCCTCCCTTGGGCATCTTCA (ADCY6), transcript ATATTAGTGCAATCCAG TGCATC variant 2, mRNA T
CAAATATGTCGGGATG
Homo sapiens leptin CGGGAGGCTGAGACAGGAGAA
ATTGGCGGGGTCCTCA HRSBom
3589 22372263 80288734 49 720566 LEP OB1 OBS NM 000230 (obesity homolog, TCGCTTAAACCTGGGAGGCGGA
TGGGCCTGCTCTTCGG ILMN-1658003 mouse) (LEP), mRNA GAGTACA
GA
Homo sapiens seven in GCCCACCTCAGCCTCC
GTGGGAAAGGGTCCAGATTTTA absentia homolog 2 AGAGTAGCTGGAAATA ,7,,™
2235 1574226 807186 61 42121 SIAH2 hSιah2 NM 005067 AAGGTGCTTTAAGGTTGCCCTC (Drosophila) (SIAH2), CAGTGCCACCCAGATA ILMN-1734267 TGCCGA mRNA GC
Hm7aP™T, CAGGACTGTGATGGTA
BPOZ PP2259 repeat and BTB (POZ) CAGGAAGGGAACGTGG 3469 23002678 8251982 55 542526 ABTB1 EF1ABP, MGC20585 NM-°32548 domain containing 1 (ABTB1 ), transcript variant 1 , mRNA
NGX6, RP11-
4 098 278 56845 56331085 82 910965 C9ORF127 112J3 10, NM_016446
MGC120460, NAG-5
5329 373 26428 72 789566 696468 UST 2OST NM 005715 C
GGTCC
CTGGCTTGGATCTCG I I I I IAAC
6357 48897263 7347356 81 71993 YPEL3 MGC10500 NM 031477 CCGTTCCTGCCCCACCTGCCCT
ATAGT
SDCCAG28, GGCTCCCAAGGCCATGAAGAAG
2 986 192 31012 86 59468 49293694 STARD10 MGC14401, PCTP2, NM_006645 ILMNJ 778974 ATGTACAAGGCGTGCCTCAAGT
NY-CO-28, CGI-52 ACCCCG
CGCCCTAACAACTTCCCATCCG
8 341 562 9226 8441884 58469288 ADM2 ^'g^ie V ^' NM-024866 ILMNJ 734184 CTGACCCCTCCAACGCCATCAA TCTCCA
GTGTAGAGTGTGCCCCGTGACA
4026 27266428 67 571045 7243248 MRAS ^2964 ^33 NM-012219 ILMNJ 813517 TCCCTCCATCTTCTCCTCCATTA TCATC
Fold change XS pOS+βGF pOS Common Synonyms Gβnbank Description Probe Sequence Probe Id Probe_Sequence_l
Homo sapiens solute carrier family 35 (UDP- CAGGTTGCAATATGAG
UGALT, UGT2, CCCCCCAGCCCCTGCCAGCTCC galactose transporter), GACTTCTCTGTCTCCTC
2 451 174 89761 7497554 71 6702 SLC35A2 UGT1, UGT, UGTL, NM_005660 ACACTATCTCTTAGCTGAGTTTT member A2 TGAAGCCTGGGACACT ILMN-1771689
UGAT TGCAA
(SLC35A2), transcript G variant 1 , mRNA
Homo sapiens coiled-
CTCTCTGAGGGAGAGGGAGCC coil domain containing
2744 197 83511 91 106415 58268333 CCDC128 "G,?«"I81' NM 152994 CTCCAAACTTCAGATCCTGTGG
128 (CCDC128), GTTTAGT mRNA
Homo sapiens cysteine CATGTCGCTCCGGTCA
PCAP, MGC119355, GCCTTTTTAGGCCACAGTGACC sulfinic acid GATTAGTTGGCTTTGG
5477 46263513 9072263 79 574036 CSAD MGC119354, NM_015989 ILMN 1697787 TGCGCAATGTTTATATGCTTTGA decarboxylase (CSAD), CCCCTCGACCCTGTGC
MGC119357, CSD CCTAC mRNA AG
Homo sapiens
GCCTCTTTGGAGCATA membrane bound O- AGGGGCTCACATCTCCCCTCTG
2 654 2098601 68 3605 93 14772 MBOAT5 C3F, OACT5, nessy NM_005768 acyltransferase domain ILMN.1697872 ATTCCCCCATGCACATTGCCTTA containing 5 TCTCT (MBOAT5), mRNA
SEST1, CCTGACACTGGAGGGCAGCTGT MGC138241, Homo sapiens sestrin 1
2 975 229 37262 7261534 86406235 SESN1 NM 014454 CTTGTGCATTACTTGTGTTCCCA MGC142129, PA26, (SESN1), mRNA GCACC RP11-787I22 1
Homo sapiens
GACTGTCCCCTGGTAC amplified in TGTGGACCTCTCGGGCAACTCT ACATATGCAAGAGACTT
2099 1751726 8926431 79592186 OS9 NM 006812 osteosarcoma (OS9), ILMN 1801236 GTGGGTGTGGGGGCCCTGGGT TATGCGTAAGAGTGGA transcript variant 1 , GAATGCT G mRNA hMusTRD1alpha1,
Homo sapiens GTF2I WBSCR11, AGGAGCCTTTCCAGTT repeat domain AACCCGGATTCAGTGGCATCGG
PRFAM1 RRΔP9 ATCTTGAGTTGCAGCT 2764 20664761 57782814 9600595 GTF2IRD1 WBSCR12 NM_016328 containing 1 ILMN 1773906 CCAACCAGATCTCACTCGTGCA CTGTAGTTTCTTGAGG (GTF2IRD1), transcript ATGGCC
MUSTRD1, WBS, CC variant 1, mRNA GTF3
Homo sapiens
TGCCTTCCTTGACCATCTACCTT abhydrolase domain
2 04 17423929 87 501816 85 19069 ABHD14A OKFZP564O243 NM-015407 GAACTAACCCACTCCCAGCTCC containing 14A CAGCC (ABHD14A), mRNA
Homo sapiens dynein,
D2LIC, CGI-60, cytoplasmic 2, light CCCATCACAGGTGACACCTTAC
2254 18883096 7207077 97 98097 DYNC2LI1 LIC3, NM_016008 intermediate chain 1 GGACGTTTTCTCTTGTTCTCGTT
DKFZP564A033 (DYNC2LI1), transcript CTGGA variant 1 , mRNA
ACCTGCTTTGCGGTGC
MGC 126758, Homo sapiens ring GGAAAGCTGTAACTCACGAAGC
AGACCCTCTCAGGAGC
2754 24398929 8002329 98 15179 RNF10 MGC126764, RIE2, NM_014868 finger protein 10 ILMN 1727220 CCTGAGACCTGCTACCCCTAAG AGGAAGACTCAGAGCA
KIAA0262 (RNF10), mRNA ATCGAG AG
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe Sequence Probe Id Probe_Sequence_l
Homo sapiens zinc CTCCTTTCCTGGAGCT
AGCCCACTTGGCCCCACCCCTC finger and BTB domain GGTTTAGCTGGATATG
2 189 204 52261 90085175 97 180954 ZBTB48 pp9964, HKR3 NM 005341 AATAAACCGTGTGGCTTTGGAC containing 48 GGAGGGGGTTTGGCTG IL - 5 TCTCGT
(ZBTB48), mRNA CC
Homo sapiens B-cell CTGTCCGGAATGCCACCCACAT
344 31899347 8547684 10089348 BCL3 D19S37, BCL4 NM 005178 CLL/lymphoma 3 CTTCCATTTCCATGTCCCCTCCC (BCL3), mRNA AGAGC
FU37039,
Homo sapiens solute
BA394O2 1, GGGTAGGGGTGGGAA carrier family 35, ATAAATGGTTCACGGTCCACTG
OVCOV1, ACTGGCATACTGTGTG
2064 17605179 89322975 8394922 SLC35C2 member C2 ILMN 1752954 GCCGCCTTGTGTTGCTGGAGAC
MGC39183. CGI-15, NM-015945D TATAGCACTGCCGATT (SLC35C2), transcript GTGGGG
C20orf5, MGC32079, GGC variant 2, mRNA
MGC20633
Homo sapiens seizure related 6 homolog ATGGCCCTGGAGATCCTACAGT
6489 527 6893 66 17761 103 19762 SEZ6L2 FLJ90517, PSK-1 NM_201575 (mouse)-lιke 2 AAATAAACCAGCATCCTGCCGC (SEZ6L2), transcript CCAAAA variant 2, mRNA
Homo sapiens DIX
GAGTCATTGCATCCTCT CTCTTCTTGCTCAGTTCCCTAAA domain containing 1
5464 389 15594 90 17309 62 17785 DIXDC1 KIAA1735, CCD1 NMJ301037954 ACCAGCTGTTAATCCAT ILMNJ 696702 TTAGCTGGGGGGATTGGGATAC (DIXDC1), transcript CACTCTGAGGGGGAGG TTTAC variant 1 , mRNA
Homo sapiens TGGAGCTGGGGGCCA
GGCCTTCCTACACATTAGCTCC sarcospan (Kras GAAAGGGGCTGGGTAC
6 116 55973096 8998132 94589294 SSPN SPN1 , SPN2, KRAG NM_005086 ILMN 1660321 AGCTAAAAAGACACATTGGAGA oncogene-associated CTCTTCTGGTTGCTGA GCTTAG gene) (SSPN)1 mRNA GTG
TTCCAGCCTGCCAGTC
Homo sapiens tubulin, CCATGCCTGCTCCCTCTGACCC ATGAATCTCAGACAGC
2727 237 08095 72053696 10742262 TUBG2 MGC131994 NM_016437 gamma 2 (TUBG2), ILMN 1666727 AGCTTCACCTCATGGACAACCC CTGCCACCTATTGCCC mRNA TTCTTG TG
Homo sapiens potassium channel GCGGGGCTCCCCAGCCATCAC
3229 285 1643 10023931 81 009125 KC™5 M1S7 NM-024076 tetramensation domain CATCCTGTGTACAATGGCTGTA containing 15 GACTTGT (KCTD15), mRNA
Homo sapiens Mov10,
FLJ32791, AGCTCTGAAGACACAGCACCCA Moloney leukemia virus
2322 217 13928 8001471 108 98929 MOV10 DKFZp667O1423, NM_020963 GCCTTCTCGCACCAGCCAAGCC 10, homolog (mouse) gb110, KIAA1631 TTAACT (MOV10), mRNA
CCTTCCTGATTGATCTTCTGAGA
Homo sapiens shroom
6 383 602 57263 8821452 10241014 SHRM MSTP013, KIAA1481 NM_020859 GCTCGAATGCTGCTGGACACGT (SHRM), mRNA ACCCC
Homo sapiens
AGCGTGCGGAGCATCT ADAMTS-like 4 GGGTAACCACGCCCAGGACACC GAAGTTGCAGTCTTGC
7 668 4765976 36284798 10951433 ADAMTSL4 TSRC1 NM 025008 (ADAMTSL4), ILMN 1784737 TCAGCCTTTCCAGCATAGCTCA GTGTGGATGGTGCAGC transcript variant 2, ATAAAC CA mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe_ld Probe_Sequence_l
Homo sapiens
CCAAGGTTCTCACACTGGCCTG interferon-induced
4387 4033018 77 33238 110485115 IFI35 FLJ21753, IFP35 NM_005533 GGCTTGGGTGCCCATATAGGAG protein 35 (IFI35), GTCTGT mRNA
Homo sapiens F-box
SHFM3, SHSF3, CCAATAGCCTCCTGGCACCAGC and WD repeat domain
2 111 22866846 10873096 10803095 FBXW4 FBWD4, DAC, NM_022039 CAGACCTCACCCTTGACCAACC containing 4 (FBXW4),
FBW4 TCTCGG mRNA
Homo sapiens CGGACATCTACCCCTG
CCCACTGCTTCAACTGGCACTC
AEP, LGMN1, legumain (LGMN), TTATCATGGAGGGGGT
3 157 302 38928 11349762 81 59433 LGMN NM 001008530 ILMNJ 775002 CCCCACGTACGAGTATGCGTTG PRSC1 transcript variant 2, ACAGGAAGAGACTGAC AGACAT mRNA AC
Homo sapiens unc-93
ACGGTCAGGGTCTTCTTGCGAC
UNC93B, UNC93, homolog B1 (C
2 586 257 38095 91 14419 111 805954 UNC93B1 NM 030930 CCGGCCCGCTCCAGATCCCCAC MGC126617 elegans) (UNC93B1), AGCTCT mRNA
Homo sapiens pleckstπn homology
GGACTCTGTCCTGTGTCACCTC
APPD. ZFYVE15, domain containing,
2706 26540594 10326435 9580598 PLEKHF1 ILMNJ 698330 TCTCCAGGTGTCCAGCTGTCTC PHAFIN1, MGC4090 N -024310 family F (with FYVE ccccACCCTGCCACTA ATGCCT domain) member 1 T
(PLEKHF1), mRNA
Homo sapiens ztnc
GGCTGTACCCGTCGAATGGAGT finger protein 419
2 531 2529643 116 17262 86393814 ZNF419 ZNF419A, FLJ23233 NM_001098495 TTTGATCTCGCTGAGTTTGGAG
(ZNF419), transcript TTGGGG variant 6, mRNA
GTCTTCCACCCCTTGTT
Homo sapiens growth GAATCCATTTGTCATCAGGAATC CCATCTGCCTGCCAAC
15 82 12806267 116218445 5603944 GAS1 NM 002048 arrest-specific 1 ILMNJ 689874 AAAACCCACAGTCCATTGTGAA CCATCGGAAAGGAATC (GAS1), mRNA GTGTG C
Homo sapiens TNFRSFIA-assoαated CTATTGCTGAACCCCTGTCCAT
MGC11078,
2 898 28469763 1105643 8944772 TRADD NM 003789 via death domain CCACGGGACCCTGAAACTCCAC Hs 89862 (TRADD), transcript TTGGCC variant 1 , mRNA
Homo sapiens
TGGCTGGGTGAAGAATACCAGC acylphosphatase 2,
4 929 43928094 69486984 11769765 ACYP2 ACYP, ACYM NM 138448 AAAGGCACCGTGACAGGCCAAG muscle type (ACYP2), TGCAGG mRNA
MGC131937,
Homo sapiens NLR
FLJ21478, NOD26, GGATGCCCTCACATTGGTGCTT family member X1 2 989 30960596 8853099 12062262 NLRX1 NOD9, CLR11 3, NM_170722 TCTCCTCATCCTCATGCCCCCTT (NLRX1), transcript
NOD5, DLNB26, TGCCA variant 2, mRNA
MGC21025
AAGGATGGTCCCAGCT
Homo sapiens CCTCAACAGGCCCAGGGAGGG GTGTCAAAAGGAAGCT 2 324 24665594 10301012 111 901794 IRF1 IRF-1, MAR NM 002198 interferon regulatory ILMNJ 721657 AAGTGTGAGCGCCTTGGTATGA TGTTTGTAATACGTGTG factor 1 (IRF1), mRNA CTTAAAA C
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens GGAGATGGTGTGTCCT
CTCACCTTGGCTGTGGGCTGTG chromosome 16 open GAACAGTGTAGCTCAG
3 1 3282393 11607678 9850185 C16ORF7 ATP-BL NM_004913 ILMN_1788786 AACATTCCGGGACCCTGGGCAT reading frame 7 GTCAGCTTGAACTTTCC CTTATC (C16orf7), mRNA A
Homo sapiens splA/ryanodine TGGAGCCCGCGTTGCTGTTCCC
3566 361 1726 12270178 85875336 SPSB3 SSB3, C16orf31 NM_080861 receptor domain and ACAGGGCCTCGGTTTTTCCTAA SOCS box containing 3 CTTGCT (SPSB3), mRNA
Homo sapiens TRAF- AACTGGGCCTTGACAA
CAGTAACGAGGCTTTTGATGTG type zinc finger domain AGTGTAAACCGCATGG
2041 211 97263 8883934 12342678 TRAFD1 FLN29 NM 006700 ILMNJ 704477 TTGAGCTGGAGGTGAGTGGACC containing 1 (TRAFD1 ), ATGGGCTTCCCCAAGG GGGGGC mRNA AT
Homo sapiens
ATACCTGTGGCCCCCC suppression of AAGCCTCCTTCTCAGTAGCAGA
HTS1, MGC33090, ACACAACTGAGCCCAT
3306 321 95593 10446846 96 580414 ST5 NM 139157 tumoπgeπicity 5 (ST5), ILMNJ 705266 GTCCAGTGCCTTGCAGAGCCTG DENND2B, p126 GCTGATGGAGTACCCT transcript variant 2, AAGCCT GA mRNA
Homo sapiens
GTCTGGCAGCCTGTGTCCACAA transmembrane protein
4504 1845 156 15202364 124 79967 TMEM119 NM 181724 TATTCGTCAGTCCTCGACAGGG
119 (TMEM119), AGCCTG mRNA
Homo sapiens TNF receptor-associated CATATCCAAGTTCACTCTGTCTT
5075 5482976 1289018 90460175 TRAF5 MGC 39780, RNF84 NM_004619 factor 5 (TRAF5), CCTGAGCAGTGGAAGATCATAT transcript variant 1 , TGCTG mRNA
GCTGTGGAACAATCAG
Homo sapiens WD ACCTCTCCAGGTCGGCACTTTC
PWDMP, KIAA1638, CCCATCTCTTTGTGACC
2394 26501428 10628095 118 180954 WDR19 NM 025132 repeat domain 19 ILMNJ680367 CACTTCTGTACGGTGGCAAAAC FLJ23127, ORF26 TGGAGCAGTCAGAGGG (WDR19), mRNA GATGAC C
Homo sapiens
CATGCCACCCTGTTTTC secretion regulating AAAGCCGGTGCAGGCTCTGCTG AGCTAAAGCCCAACCT
3979 40481427 8380601 13023512 SERGEF Gnefr, DELGEF NMJ312139 guanine nucleotide ILMNJ 738742 TCATCGTCAGGACTCCTTGTGG CCTGACCTGTCACCGT exchange factor GCTGTG G (SERGEF), mRNA
FLJ25909,
Homo sapiens multiple CCCAACCCCTAGCTCACCTCCT
DKFZP781P216,
2 105 23264761 13040594 93 33514 MPDZ PDZ domain protein ACTGTAAAGAGAATGCACTGGT
FLJ34626, MUPP1 , ™™I-UU'*«B (MPDZ), mRNA CCTGAC
FLJ90240
Homo sapiens myeloid
MZF1B, ZSCAN6, TGTCCGCCATGGTCAGAACACC zinc finger 1 (MZF1),
2307 281 5476 12245595 12228928 MZF1 MZF-1. ZNF42, NMJ98055 TACCTCCCCTGGTTATTGTGAG transcript variant 2,
Zfp98 GCTGGC mRNA
CTCCTGCCCTCCAACCCTTCTG
Homo sapiens paired
5556 462 86426 53757637 13284761 PAX9 NM 006194 CCTTGAAAGCTGGCTGTACGGA box 9 (PAX9), mRNA CTCACA
Fold change XS pOS+βGF pOS Common Synonyms Gβnbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens AGCTTCTGGGAAGGGA
GGCCATCTGTGGCTGGAGGGTT mannose-6-phosphate GAGAGGGGAGGTCTG
2 274 28037262 113610115 13341013 P76 NMJ 73542 ILMN 1737699 CTGAATGTCCTCTCTCCATGTCA protein p76 (P76), CATAAAGAGGGAGTTT GGCAG mRNA TGG
MAN6A8, Homo sapiens
TTTTCCGTGTCTTCACCCGCGG
DKFZp686E23167, .„..,. mannosidase, alpha,
202 23079346 11020178 121 74762 MAN2C1 MANA1. MANA, NM_006715 TCGTATTGGAGACCGTCAAGCA class 2C, member 1 GGCGGA
MGC87979 (MAN2C1), mRNA
Homo sapiens leucine CCCCAGAGCCTGTGGA rich repeat and sterile GATAGAGCCTGTTTGC CCTGCTCTCCACAACTGTCCCT
FLJ31641, RIFLE,
2 768 319 1101 1065435 12848094 LRSAM1 NM 138361 CCTTACCCCATGTAGCTCGATC TAL fP,h* m° ∞ntainin9 TGCTTTTTCTTCCCGCT 'LMNJ752923 1 (LRSAM1), transcript CGAAGC variant 1, mRNA
TGAGCAACCAAGAGTC
Homo sapiens dual TTCCCCTTATCCCCACTGCTGT
JSP1, JKAP, MKPX, CCAGCCCCACCAGTAT
2 176 271 55594 111 430954 139 38928 DUSP22 NM 020185 specificity phosphatase ILMNJ 754035 GGAGGTTTCTGTACCTCGCTTG VHX CTGCTTCTGTAGCCCA 22 (DUSP22), mRNA GATGCC
CG
Homo sapiens BAM- GTGGCAAGGAAGAAAG
TCTGCCACGTGCTGACGGTCGG associated protein 2- TGTTCCGAGCATCGGT
379 43059344 11306012 119651794 BAIAP2L1 IRTKS NM 018842 ILMNJ 742260 GAAGCTTCAGTGGAGAGGCCTA likβ 1 (BAIAP2L1 ), GGCTCTAACGCCAACA ACTCTA mRNA GC
Homo sapiens poly
ADPRTL3, (ADP-πbose) CACATGAACACAGACA
GCAAGGCTGGACTGTGATCTTC ADPRTL2, ADPRT3, polymerase family, CGCAGGGAGAAGGCA
3603 45218927 11365178 14062679 PARP3 NM 001003931 ILMNJ 662463 AATCATCCTGCCCATCTCTGGTA pADPRT-3, IRT1, member 3 (PARP3), GCCGTGTGAAGGAGTC CCCCT hPARP-3 transcript variant 1 , GGA mRNA
Homo sapiens
MGC4307, oxysterol binding CCAGAGGTGGAGGAAGAACGG KIAA0772, ORP2,
2628 3355268 14543095 114751785 0SBPL2 NM 144498 protein-like 2 TAGGAAGGCTGATGGCAAAAGC MGC8342, (0SBPL2), transcript GGCTGTG FLJ20223, ORP-2 variant 2, mRNA
Homo sapiens CDC14 cell division cycle 14 GCGCTGCCTTTCTTCA
CDC14B3, CCGCTGAAACTGCCCTGGAGAG homolog B (S GCAACAGACCCTCAAA
3093 40507263 115814285 14780595 CDC14B hCDC14B, Cdc14B1, NM_033331 ILMNJ 724959 GCTATCTGCTGCTCTTCCATTTA cerevisiae) (CDC14B), CCAAGAGGAAGCTAGA
Cdc14B2 CCCAC transcript variant 2, TG mRNA
GAATGCTATCATCCTG
Homo sapiens protein AGACAATGCACCTAGCTGTGCA
PKD, PKCM, PKC- CTTGCCTGTCCATTTGT
324 44134344 12375595 15137262 PRKD1 NM 002742 kinase D1 (PRKD1), ILMNJ 652826 AGACCTAGTGCTCTTAAGCCTA MU, PRKCM GGAACAGCATCTGGTG mRNA AATGCC A
Homo sapiens N-
CCCTCGGCCTTGTCCC acetylglucosaminidase, TCGCCACCACTGGGCCTTGTTT
MPS IHB, NAG, GGGATCGCTCCGTCGC
2163 3006726 12991013 1499851 NAGLU NM 000263 alpha- (Sanfilippo ILMNJ 690284 TCCGCT AATTCCAGGGCAGATT MPS3B, UFHSD ACCCACCATGATGGAA disease MIB) (NAGLU), CCAGGG GA mRNA
Fold change XS pOS+βGF pOS Common Synonyms Gβnbank Description Probβ Sβqueπce Probejd Probe SequβnceJ
Homo sapiens solute carrier family 3
GGGGACCCCACCTCCC
CD98HC, 4T2HC, (activators of dibasic AGGGGCTGTAAGTGCCAACATG TCCAGGCCTCTTCAGA
226 31975595 14564761 138 58511 SLC3A2 MDU1, NACAE, NM 001012661 and neutral ammo acid ILMN 1742221 ACTGTGAAGGGCCAGAGTGAAG GAAGACCCAACAGTGA 4F2HC, CD98, 4F2 transport), member 2 ACCCTG CG (SLC3A2), transcript variant 1 , mRNA
CTGTACTAGGCCTACT Homo sapiens myosin, rnrr..τr.nAnττrrr GGCTGACAAGATGACGGCGGA
258 34660596 11696428 15525595 MYL5 NM 002477 ss^r^ AGAGGTGGACCAGATGTTCCAG TTCGCCT
C
Homo sapiens ^^ ILMN-1813581
FLJ11743, GGGGGGCTGGCGCCACCGAAC abhydrolase domain
2409 31795178 111 91846 15885596 ABHD8 MGC14280, NM 024527 CTGCACATCTCAACTTGTAACTC containing 8 (ABHD8),
MGC2512 AATAAA mRNA
Homo sapiens HCV F- GTGGTAGATCACTTGAGGTCAA
2918 42282263 131 14345 15933511 LOC401152 NM 001001701 transactivated protein 1 GAGTTGTGACACCAGCCTGGCC (LOC401152), mRNA AACCTG
Homo sapiens GGAGTTTAGAAGAAGG
PP791, RP4- ATGGCCCCGCTGTGGTCCCCTC
KIAA0319-hke TCAGAGCCCTGGGCAG
2407 34068097 139 39761 146 3393 KIAA0319L 765A10 3, NMJ324874 ILMN_1716994 TCTGTCCCTCCATCTGTATGTGT
(KIAA0319L), transcript TGTTGGGCCAGGCTTT
KIAA1837, PKD1-lιke TCTGT variant 1 , mRNA AG
Homo sapiens RAB7, GCTGGGGCCCGGGGA
GCAAGTGACATCAGCTGGCTGT
RΔR7I member RAS TCTAATTGTTTAGAGAG
2 595 34873096 113 16428 161 70178 RAB7L1 DKFZp686P1051 NM_003929 GATGCTTCGAAATAGGTCTGCT oncogene family-like 1 CCCCAAAAGTGGCTCA CCTCAC (RAB7L1), mRNA GA Homo sapiens nuclear CACCTGCCCCGGGTTT
CTGGCCCTACCTCACAGCTGAA pore complex TGGAGAGGATGTGCCC „ ,.., ,„„ ...
3 159 444 1476 161 79346 122 82678 NPIP NM 006985 AAACAGGATGGGCC interacting protein AATAGGCTTGTCGATAA ILMN-1806473 ACTTTAAA ACCAGC (NPIP), mRNA C Homo sapiens CAAGCCACGACCAACC
GATCAGAGTGGGAAGACCTCAG adenylate cyclase 6 AGAGCCCAAACTGCCT
3456 48626428 119 80595 167 34344 ADCY6 ^^s NM-.020983 CCTTGGGTGGCTTGTCTCTGCT (ADCY6), transcript GCCACCACGAGCATAT ILMN-1736929 TCTTGC variant 2, mRNA CC
Homo sapiens aldehyde TAGCCCTGATAGTCGG
GCTTGAGAAACCTACATTTGGA dehydrogenase 3 GCAGCTTAGAGGAGTG
6263 720756 85 39186 16763095 ALDH3B1 ^33' ALDH7' NM.000694 ILMN_1808530 CAATGAGAGGCTGCTCCTGCGG family, member B1 GGGAGGAGAACTCAGC CCTGCG (ALDH3B1), transcript CT variant 1 , mRNA
Homo sapiens
MGC125648, chromosome 10 open GCAGTCCCCTGTGTTTGCCAGA
2019 307 15594 161 18094 144 58511 C10ORF26 FLJ20367, NM 001083913 reading frame 26 GATACTGTGCTCGAAGTAGAGG FLJ20154, OPAL1 (C10orf26), transcript TAC variant 1 , mRNA
Fold change XS pOS+6GF pOS Common Synonyms Geπbank Description Probe Sequencβ Probejd Probe_Sequence_l
Homo sapiens Rab
FLJ30380, GATGCCTGGCAAAACCACCTCC interacting lysosomal
2805 42233096 13422263 16925595 RILPL2 MGC7036, NM_145058 CTGTGCCACACAGACACACTAG protein-like 2 (RILPL2),
FLJ32372 GCCTGT mRNA
CTTcccGCCCGGCACCccACTT
1353 1565 9392 17059344 7672356 CDC42EP5 NM-145057 ILMN_1705685 CTGTAT ACATAAACGGCCAAGG TGTGTG
Figure imgf000137_0001
GGGGACTGTCTGTCAT
DKFZp564C206, Homo sapiens zinc CCCCAGCAGAGTTGAGTAGTTG GCCTGGAGGCTCTTCG
2211 3536726 167 10596 15386429 ZNF25 KOX19, Zfp9, NMJ45011 finger protein 25 ILMNJ 662417 TAGCAGACACCACATGCCCTTG GCACACTTCCCCATCTT
FLJ31890 (ZNF25), mRNA AGCCTA
T
Homo sapiens
MGC131853, FGE, GGGCAGTCATAAGCTCTGTTTC sulfatase modifying
2 363 39922263 16007262 17846428 SUMF1 AAPA3037, NM_182760 CCCCTCTCCCCAAAGCCTTCAG factor 1 (SUMF1),
MGC150436 CGAACG mRNA
Homo sapiens Fc
AAGACAAGCAGGAGGG fragment of IgG, TGTGATTCCAGCCACCGCCTGA TCGACATGGACTGAAA
94068506 63733154 18640178 FCGRT FCRN, alpha-chain NM_004107 receptor, transporter, ILMNJI 734508 CCATCCGCCATTCCGACTGCTA TCACCCTCTGCAGCTG alpha (FCGRT), AAAGCG GG mRNA
Homo sapiens TGACTAGAGGCAGAGC
SSI-1. CISH1, SSM, CTCCTGGTGCTCCCTCTGGGTC suppressor of cytokine CCGAGTAGAAACAGGT
4564 693 72266 191 78928 122 20595 SOCS1 CIS1, JAB, TIP3, NM_003745 ILMNJ 808018 CCCCTGGTTGTTGTAGCAGCTT signaling 1 (SOCS1), CTGAACGGATGGAACT
SOCS-1 AACTGT mRNA GC
ATCCAGGCGGGAGCAGAAGCTA
2 17 352 18512 19318512 136 1101 MAGED2 NM-201222 family D, 2 ,MAGED2), ^^^^ ^NJ668242 AAGCCAAAGCCCAAGAGAGTGG CAGTGC
Figure imgf000137_0002
Homo sapiens G GTGCTATCTGTTCAGT
GTGCAGCCACTGTTAAGCCATG protein-coupled GATGCCCTCAGAGCTC
2463 43873096 174 28928 182 97263 GRK5 GPRK5 NM 005308 ILMNJ 724686 TGTTCCAAGGCATTTTAGCGGG receptor kinase 5 TTGCTGTTAGCTGGCA GAGGGG (GRK5), mRNA GC Homo sapiens
TGAAGAAGTGCATCAGGTGCCA
ZZZ5, ZZANK1, mindbomb homolog 2
3 557 571 82263 15527261 17631012 MIB2 NM 080875 GGTGGTCGTCAGCAAGAAACTG
FLJ20648, FLJ39787 - (Drosophila) (MIB2), CGCCCA mRNA
Homo sapiens cellular AGCAAGTGCCTCGGCC
CCAGCTTCAGCCAGGGACAAAA repressor of E1A- CAGTCTTCCTGTATTTA
3 118 507 9143 156 95595 17647263 CREG1 CREG NM 003851 ILMNJ701629 TCCCCTCCCAAACCACTCTCCA stimulated genes 1 TGTGGAAGGCGGCGG CAGCTT (CREG1), mRNA CT
Homo sapiens
GCCAGGCCATGCAGGGAATGC metastasis associated
2051 36328094 16744762 1904643 MTA3 KIAA1266 NM_020744 CAGTCCGAAACACTGGGAGTCC 1 family, member 3
AAAGTCT (MTA3), mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe Sequence Probe_Sequence_l
Homo sapiens RAB13, CATCATCAACTTCCAAT
GAGCAGGGGAGAAATAGCAGA member RAS GTCTGGACAACTCCTT
2 485 437 68097 15505595 20224344 RAB 13 GIG4 NM 002870 ILMN_1770228 GGGGCTTGGAGGGTCACATAG oncogene family CCTGTTGAGGGTCGAG GTAGATGG
(RAB13), mRNA C
Homo sapiens leptin
TGAATTGAGCTTTTTGCCCACA receptor (LEPR),
15 18 2179481 10398166 20519345 LEPR OBR, CD295 NM 001003679 GATTCTTGATTTGTAGTTGTTTG transcript variant 2, GCAGG mRNA
GCGTGAAGTCTCAGCTTTGAGC
Homo sapiens netrin 4
1496 1705 1143 137 13104 134 3891 NTN4 FLJ23180, PRO3091 NM_021229 TGGAGGCTAGATTCCAAGATGA (NTN4), mRNA CAGCCA
Homo sapiens ubiquitin conjugating enzyme GAAAGTGAGCGAGGAG
GCCTGCTGAACTCGGAGGGGA
UBCH2, E2-20K, E2H (UBC8 homolog, TCAGAAACTCAGCCAC
2 394 46073096 18986429 19646011 UBE2H NM 003344 ILMN 1704912 GTTTGGAGAAATTTTAGACAGCA UBCH, UBC8 yeast) (UBE2H), TGGTTGCCTTGGTAGG
GCTCTG transcript variant 1 , CA mRNA
Homo sapiens PTEN induced putative kinase GGACTGAGGGACCAAG
CACGAGGAACTCGTTTGAAGGG
FLJ27236, PARK6, 1 (PINK1), nuclear GAAACATGATGGGGGA
3408 66621423 18838095 20403928 PINK1 NM 032409 GGCAGCGTAGCATGTCTGATTT BRPK gene encoding GGCAGAGAGGGCAAGA - GCCACC mitochondrial protein, GT mRNA
I-FLICE, CASP8AP1, CASH, C-FLIPL, Casper, FLAME1, Homo sapiens CASP8 GGGCTGAGAGTATGGG
GTGCCTACGAATAGCCACTGCA CLARP, USURPIN, and FADD-likβ GAAAAGAATCAAGAGA
2433 49662262 21842679 191 49762 CFLAR NM 003879 ILMN_1696827 TACCAACCTGGGCAATATAGCA FLIP, c-FLIPR, c- apoptosis regulator CCTGACTGCCGCCAAC AGATCC FLIPS, c-FLIP, (CFLAR), mRNA TC MRIT, FLAME, FLAME-1
Homo sapiens ACTAAGCCCACCTCCC
TCACAGTAGCCTTGCTGAAGCC
KIAA0113, NAF1, TNFAIP3 interacting CTGCTCTCCTTCCCAG
3021 633 10596 22081427 19844762 TNIP1 NM 006058 ILMN_1666819 ATCACAGATGGGAGAAGGCCAT ABIN-1, VAN protein 1 (TNIP1), CATTGAGCCCTTGGTT GCCAGC mRNA GC
Homo sapiens CAGAAGGCTCAGAAGT
FU, serine/threonine kinase rrτrhτrτrl.rrΛ~Λ~ GGCTCAACCCCTCTTTCAGCTT
2 169 433 13095 2022143 20051845 STK36 DKFZp434N0223, NM_015690 36, fused homolog ∞^^? ILMNJ770610 CTATGTGGTGTTGGAGGTGCTG
KIAA1278 (Drosophila) (STK36). GTGCGGGGAGACATTC GTATCG mRNA
Homo sapiens annexin AAGCGGGGAGAGGGTA
GCCAAAACTTGTTTCCACATTAA A11 (ANXA11), CACAATGGGTATCTAAT
2 505 49426846 17323929 2254226 ANXA11 CAP50, ANX11 NM 001157 ILMN_1808732 GAGTCAGCCAGCTCTGGAATGG transcript variant a, AAATACTTAAGAGGTG TCTGG mRNA G
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probβ_Sβquence Probejd Probe_Sequence_l
Homo sapiens v-src sarcoma (Schmidt-
GAGGAGGTGCCTTCTG Ruppin A-2) viral ACCCAAGTCTTCTCCCGTCCATT GGTATCTCTGTGTTGG
4 185 83641016 192 93512 208 77261 SRC ^ ^ NM-198291 oncogene homolog ILMNJ 794829 CCAGTCAAATCTGGGCTCACTC TGTATCTGTGCCATTG (avian) (SRC), ACCCC GC transcript variant 2, mRNA
Homo sapiens
TGGGGACAAGGGCTGC transcription elongation CACGTCCTCCGTTGACACAGCT
TTCCAGTTCTTGGATG
84308093 17836012 22689343 TCEA2 TFIIS NM 198723 factor A (SII), 2 ILMN_1732149 TCTCTGGAGACCCT AGAAGGCG
GCGTTCTCCTATCTACC (TCEA2), transcript GCATGT
T variant 2, mRNA
Homo sapiens
TCTGCCCCTCCCTGCC argininosuccmatθ CCAGAGCAAGGTCACTGCCAAA CGCGTTTCAGGGCCTC
2885 27404976 48385597 227 03513 ASS1 CTLN1. ASS NM_054012 synthetase 1 (ASS1), ILMN 1789240 TAGACCCGTGTACAATGAGGAG GGTCCATAGAGAACAC transcript variant 2, CTGGGG CA mRNA
TGCTGCTCTTGCACTT
Homo sapiens SIX GCCCTTGTCCTCATTATCCGGC GCTGGAATGTACAGGG
3028 547 19763 22923929 14409763 SIX5 DMAHP1 B0R2 NMJ75875 homeobox 5 (SIX5), ILMNJ 813670 CCAGACCAAAGATTCCCTCATC TGGGCTGGTTGGCCCT mRNA CCTGGG AT
Homo sapiens zinc
TTTACCACTGCTGTCAAGCCAC finger, AN1-typβ
224 467 58093 21221844 207 84761 ZFAND3 FLJ13222, TEX27 NMJ321943 AGCCCTTGGCCACCATACGGGC domain 3 (ZFAND3),
CATCCT mRNA
Homo sapiens family GAGGCGCTCAGGGAAA
GCATGTGTGCGCGTGGCCGTG with sequence GCTGGACTACTAAAGT
2443 496 13928 229 11845 183 55179 FAM100A FU31223 PP11303 NM-145253 ILMNJ 763347 TCTGTGTATTTCTACGTGTGTCG similarity 100, member GAACTGGATGGCCCAC CTCTTC A (FAM100A), mRNA AC
AGGGACACACCCTGAT
GGTCCCCATGTGCCTGTTGTTC Homo sapiens sortilm 1 AGCACAATCTCCTTGG
369 675 9309 20338512 175 56427 SORT1 NT3, Gp95 NM 002959 ILMNJ 775048 AGCCCTCTCTCTTGTTCCCTTTC (SORT1), mRNA GGCCCTGCCCACCTCC TGAGC
AG
CYT19, AS3MT,
Homo sapiens RP11-753C186, GTGGTATCATTATCAGGCCAGC chromosome 10 open
2 427 46096014 151 08511 239 05595 C10ORF32 FLJ40752, NMJ44591 TGCAGCCTCTTGCCTTGACCTG reading frame 32
DKFZp686B2219, CATTCC (C10orf32), mRNA MGC27171
Homo sapiens vestigial GCGCTGCCTGCAGTGCGCTCT
2 952 631 35596 24037262 191 06429 VGLL4 KIAA0121, VGL-4 NM_014667 like 4 (Drosophila) GACCTTCTCTTCATGTGTGTAAA (VGLL4), mRNA TCTGTA
ACGCCGCTGCTGCTCC
Homo sapiens CCCTAGAAATTAGAAAATCAAGC GGCTGAGTATCTAGCT
2672 5006726 24063095 147 5893 LMOD3 DKFZp313F0135 NM_198271 leiomodin 3 (fetal) ILMNJ 709734 TTTGGGCCAGGTGCGGTGGCT TGTCTCCCCGATGGGA (LMOD3), mRNA CATGCC
Homo sapiens zinc GGCCACACAGCCAAGA
GTCCCAACAGCCATGAACCATG finger protein 90 AGAGCCCATGCAACTC
329 7302226 20423929 241 69762 ZFP90 ZNF756, NK10 NM_133458 ILMNJ671142 CACTTATGGATACCCAGCCTTTT homolog (mouse) AGTCCAGGATΠTACTG AGGGC (ZFP90), mRNA G
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probβ_Sequencβ Probejd Probe_SβquenceJ
Homo sapiens sperm CTGCTATTAGAGCCCATCCTGG
ACRP, FSA-1,
2681 6183268 23706845 22540594 SPAG7 NM 004890 associated antigen 7 AGCCCCACCTCTGAACCACCTC MGC20134 (SPAG7), mRNA CTACCA
GAGGGTTGTCCGTGAT
Homo sapiens stomatin CTCTGGATGATGCCACTGATGC
CCACAAGGCATTAGAG
2735 60076013 2462768 19828513 STOM EPB7, EPB72, BND7 NM_004099 (STOM), transcript ILMNJI 815205 CTGGGGAAT AAAGGTGGAGCGT
CATGGGTGGCATGGAG variant 1 , mRNA GTGGAA AA
Homo sapiens poliovirus receptor-
CAGTCTGTTCAATACCACCTTCG
PVRR2, HVEB, related 2 (herpesvirus
2 849 623 10596 198 14345 247 76012 PVRL2 NM 001042724 TCTGCACAGTCACCAATGCCGT PRR2, CD112 entry mediator B) GGGCA (PVRL2), transcript variant delta, mRNA
Homo sapiens solute
CCGTGTGAGCCAGTCC earner family 20 TCTGAGGCCCACACAAAGCTGG
— -VAR, ^ NMJ)∞749 AGGAGGGTGTAAGTTC
2273 54923926 2482768 237 39761 (phosphate ILMN_1687501 ACACCCCCAGGCTCTACTCCAT TGAATGGTTCCTTGCT transporter), member 2 CCCATT GA (SLC20A2), mRNA
PREDICTED Homo
AAATGTAGGACCTATCGTCCAG sapiens brain
3526 7537643 21404346 222 97679 BEXL1 XM 936467 ACTCACAGAGTGGGGCTCCAGA expressed X-linked-like ATCTCC 1 (BEXL1), mRNA
Homo sapiens RhO
KIAA0337, guanine nucleotide TCCCACTTGAGAGCAGCCTCTA
2042 4544226 26428928 18793095 exchange factor (GEF) CCTGACCCCCTGGACCACAGAG 17 (ARHGEFI 7), AGCCAC TEM4 mRNA
H2a-615, H2A, CGCTACAAAGCAGCCA Homo sapiens histone CTGTGCπACTGAACG GGCCCGCGTCTCGAAGGGGCA
3021 636506 1928601 2427976 HIST2H2AA3 "SAA. H2A/q, NM-°∞516 cluster s, i-uaad -,___________.._.__ ILMNJ 764231 CCTGTGAACTCAAAAGGCTCTTT
(HIST2H2AA3), mRNA 6CCTCCCCCTGTATCG TCAGAG H2A/O, H2A 2 KYO-T, SLIM1,
Homo sapiens four and CTAGAGGGGGAGTTGAGCAGG
2592 39052227 9469763 26958093 ■*» ^11PHUB, -.001449 a half LIM domains 1 CGCCAGGGCTGTCATCAACATG (FHL1), mRNA GATATGA bA535K18 1
Homo sapiens von
GAAGCTGACAATGACT Hippel-Lindau tumor TTCCTGTGCTCAAAAATGAGAGT
HRCA1. RCA1, GCATTCAACGGGGCCA
2542 6495143 24280594 2702726 VHL NM 198156 suppressor (VHL), ILMNJ 793537 GACGGCTGGCATGGTGGCTCC VHL1 TGGCAGGAAAGCTGAC transcript variant 2, CGCCTG CC mRNA
Homo sapiens tnbblθs CATGGGGCTTCTGACCTGAGCA
TRB3, C20orf97,
3 563 821 18097 27624762 18965594 TRIB3 NM 021158 homolog 3 (Drosophila) CCAAGGTTGAGGGACAGGATTA SKIP3, NIPK, SINK (TRIB3), mRNA GGCAGG
AGTGGTCCATGTCTGT
Homo sapiens testis- AGCCCGTGGTCTCAGGCCTCCA
GCTGGCTGGAAGAGG
2251 54744763 254 1726 2369226 TESK1 NM 006285 specific kinase 1 ILMNJI 706088 ACTTTGGCCTTCAGGACACCCT
GCTTGCTTAGGGCAGC (TESK1), mRNA GTAAGA
TTC
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
RP1, G11, D6S60, Homo sapiens GAGCGTCCTGTTAAGG
TTGGGAAGGCTTGGGAGCCAG HLA-RP1, serine/threonine kinase CACATGCTAACTTCCCA
2 944 715 11426 271 8018 2246518 STK19 NM 004197 ILMN 1807072 GATGAGTGTCGGGCTCTCGTGT MGC117388, 19 (STK19), transcript CTCAAGTCTGGCAGCG
GTGCAAA D6S60E variant 1 , mRNA C
Homo sapiens protein CAGCGGAACCGCCCAG
HRMT1L1, argiπine GATCAGATTGCATGTG GCACCTGGCTTCTGCACACTCC
2824 76833923 25695593 28831012 PRMT2 NM 001535 methyltransferase 2 ILMN 1686555 TGCGAAAGTCGGTGAACATTCA MGC111373 ACTCTGAAGCTGACGA
(PRMT2), transσipt CTCCAC AC variant 2, mRNA
Homo sapiens annexin
GGTAGCCTGTGCATCTGGTGAG
A11 (ANXA11),
2 799 807 58093 28393097 2937143 ANXA11 CAP50, ANX11 NM_001157 TGTGTCACGAGCTTTGTTACTG transcript variant a,
CCAAAC mRNA
Homo sapiens
FLJ11656, CED12, engulfment and cell GCCTCTCTCCCTGGACATACGT
2 142 624381 29268512 2907726 ELMO2 CED-12, KIAA1834, NMJ 33171 motility 2 (ELMO2), TAGCACATTGGCATTCAGTATTG
ELMO-2 transcript variant 1 , GTGGC mRNA
Homo sapiens
GCTGTTTTCAGCCATGT TTCCCCAATCCTGGCAAAAGCC coatomer protein
3476 85333923 19943095 30670593 COPZ2 MGC23008 NM 016429 TTCTCTGTGCATCTCCA ILMNJ 729640 CAAAGATCCCAGGGTCAGGAGA complex, subunit zeta 2 GTAAGCAGAAGGCTAC GACCCC (COPZ2), mRNA
Homo sapiens solute earner family 3
4F2HC, CD98, 4F2, (activators of dibasic TAGGGGTTGAGCCACCATCTGA
2 001 581 0643 30329346 28071844 SLC3A2 CD98HC, 4T2HC, NM_001013251 and neutral ammo acid CCGCAAGCTGCGTCGTGTCGCC
MDU 1, NACAE transport), member 2 GGTTCT (SLC3A2), transcript variant 6, mRNA
Homo sapiens aryl TAGGAATCTATGATGCT
ARA9, FKBP16, TTCTCCCATTGACAGGAGCACT hydrocarbon receptor GATGGTGATGGAGATT
2268 6549393 317 1143 264 78094 AIP XAP2, SMTPHN, NM 003977 ILMNJ693771 TGGCCCTGCCTTACCTGCCAAG interacting protein TTGATGTGGATGATGC FKBP37 CCCACT (AIP), mRNA C
Homo sapiens
TTCACTGTGGGTTGGG phospholipase D CCCTGGCCCACCCCCACTTTCC GGAGCTAATTTTAAGCA
3239 8906726 235 10178 323 97678 PLD3 HU-K4 NM 001031696 family, member 3 ILMNJ 798187 AGGGCAAAAAGGGCCCAGGGT TGTTCAGTGGCAGCTC (PLD3), transcript TATAATA C variant 1 , mRNA
FLJ13308, Homo sapiens YEATS GCAAGTACAGAAGGAATCTATT
3814 1068856 23406427 3354018 YEATS2 KIAA1197, NM 018023 domain containing 2 CTCAGCAGGGCATAGGGCACG FLJ10201. FLJ12841 (YEATS2), mRNA CACTGGC
Homo sapiens
TCCAACGCATCCCTGCTGATCC pregnancy specific beta
3978 100057263 18862677 33606845 PSG9 PSG11 NM 002784 AGAATGTCACCCGGAAGGATGC 1 -glycoprotein 9 AGGAAC (PSG9), mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
TGCACGGCTCCAGCTC Homo sapiens cysteine AGCCCATTGAGCCAAT GAGCTGGAAAGCCCTGGCACAA
2 538 7596226 337 1726 268 13095 CSRP2 smUM^05 NM_001321 and glyαne-nch protein ^cTGCTGCTCCCAGT ILMN-1™138 AAACTGTTTCCGATGTGCAAAGT 2 (CSRP2), mRNA AACTGCTGCTCCCAGT GTGGG
Homo sapiens ral guanine nucleotide AGTGCCATTCACCACTGCGTCC
2 165 653 006 271 1643 3398476 RALGDS
Figure imgf000142_0001
EF' NM_006266 dissociation stimulator TGGGCTTTACGAGACCATGCAA (RALGDS), transcript GACGGG variant 1 , mRNA pp9320, Homo sapiens nuclear
ACCTCTTTTGTTGGGGAAGGGT receptor binding 2824 8836893 3354643 29215594 NRBP2
Figure imgf000142_0002
NM_178564 GGCATTCTGCTGACCACAGCAC protein 2 (NRBP2), TCCAAC
DKFZp434P086 mRNA PEDF-R, FP17548,
Homo sapiens patatin- AAAACCACAAGGACCA TTS2, TTS-22, TGAGGCCCCGCGCACCTGTGC like phosphohpase CCCCCACAAGGAGGAA
2 753 85934766 283 87262 342 95593 PNPLA2 ATGL, NM_020376 CTTAATCTTCCCTCCCCTGTGCT domain containing 2 AGCCACAAGGACCACC -
DKFZp667M109, GCCCGA
(PNPLA2), mRNA CG 1110001 C14Rιk
Homo sapiens GGGGTTTGAAGAGGAA
GTCAACACGCATTGTCCTTGTC bromodomain
2459 7743893 313 3351 320 1143 BRD3 KIAA0043, RING3L, ^007371 GCCAGTTGTGGGAGTC
ILMN 1792931 ATTTGGGCCCCGAGCTCTGACC containing 3 (BRD3), TCTTTGTTACACCCCCT CTCGTG mRNA C
Homo sapiens
CCATGCCGATGGAGCAGCAGTA collagen, type XVI,
3559 1001 33923 345 1643 23430179 C0L16A1 FP1572, 447AA NM_001856 CCCACCCATGAAAACCATGAAG alpha 1 (COL16A1), GGGCCT mRNA
Homo sapiens protein arginine TGGCTGGGTCGGAGCTCCATGT
HRMT1L1,
2661 837256 28506427 34894763 PRMT2 NM 001535 methyltransferase 2 TCCTAAGCTAGGTCTAGGTCTA MGC111373 (PRMT2), transcript CACTCC variant 2, mRNA Homo sapiens CCAAT/enhancer GGGATCAACTGTACGC CGCCGGGTGCCCGCTGCAGTT
C/EBP-delta, NF-IL6-
11 73 24666475 125797615 3492893 CEBPD NM 005195 binding protein CTTTGGTATCTGACCAT ILMN_1656413 TCTTGGGACATAGGAGCGCAAA beta, CELF, CRP3 (C/EBP), delta AAAGTCTTTTGCTCCGC GAAGCTA (CEBPD), mRNA Homo sapiens
CCAGGGCGGTTCCAAA fibroblast growth factor AATGATGGAAGGAAGACTGGGT CTCTAAACCGTTCCCAC
2604 7442726 237 53928 35362262 FGFRL1 FGFR5, FHFR NMJ321923 receptor-like 1 ILMN 1775956 TGCAGGGACTGTGGTCTCTCCT CGTCAGGGAGACCTAC (FGFRL1), transcript GGGGCC A variant 3, mRNA Homo sapiens GGAACTCTGATGCTCT
TTAAAACGCTCTCCCGACTCGC chromosome 16 open GCGTGGGACCATGCCT
2 169 717 6726 334 1643 32970596 C16ORF68 MQC2g^' NM_024109 ILMN 1803197 CCACAGATTGAAAAATGCCTGC reading frame 68 GAACTCCCCGAATAAC ACAGCC (C16orf68), mRNA TG
GGAGAGTGCAGAGAAG
CCCTCCCATGCCGTTCCACTCC
Homo sapiens cortexin GAGATCGGCTTGTGGT
3758 10903142 231 14761 3626101 CTXN1 CTXN, FLJ25968 NM_206833 ILMN 1741133 TCCCTGCCTCTGAGCCGAACAT 1 (CTXN1), mRNA TTCACCCTGAGGAACT GATAAT GG
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe_ld Probe_Sβquence_l
Homo sapiens GACTGTGTGAAGCCGTTTGTGT
3582 10509642 3669601 237 54346 KIAA0355 NM_014686 KIAA0355 (KIAA0355), GGTCTCCATGTAGGTGCTGTGT mRNA TCCCGG
GAGGATGACTCTGAAG
DKFZp686B09139, Homo sapiens BSD CCAATGAGTGAAAGGGATCGTG AGGAGCAAAGGCAGCT
2905 1039231 361 95593 3538018 BSDC1 RP4-811H247, NM_018045 domain containing 1 ILMNJ 788689 GGTCAGGGACACCGAGAGAGT GTTGTTCGAAGACACC
FLJ10276 (BSDC1), mRNA GAGGTCA TC
Homo sapiens
RNF49, MALT2, baculoviral IAP repeat- GTGGTGGTATGTGCCTGTAGTC
347 1032 0143 376 13095 242 88095 BIRC3 API2, HIAP1, AIP1, NMJ82962 containing 3 (BIRC3), CCAGGCTGAGGCAAGAGAATTA
MIHC, HAIP1. CIAP2 transcript variant 2, CTTGAG mRNA
FLJ45605, dJ187J11 3, ESNA1, ACAAGGTGCTAAAACA
Homo sapiens nuclear CTGTAGCCTGGGTGTACGTTTC Nbla00052, GGTTCACCCCGATACT
8442 2346606 1979643 380 1726 NCOA7 NM 181782 receptor coactivalor 7 ILMNJ716195 ACTCAAGTTCTCCTACTGAGGA NbIaI 0993, GGCATCTCATCCAAGG (NCOA7), mRNA CTCTTG ERAP140, CC MGC88425
GGGAACGGGTTGTTGG
Homo sapiens MAX GGCCACCTGTCCACCGTGTGG
MSTP149, MAD4, CCAGACAAGTCCCAGA
7615 21859727 217 12262 394 9768 MXD4 NM 006454 dimerization protein 4 ILMNJI 702107 GCCGTGCTGTGTCCTTATGTCA MST149 AACTGCCTGCTTTGAA (MXD4), mRNA TTGTAAT GC
Homo sapiens cccTGTGCCGTTATTA pregnancy specific beta CTCTATCTGAGTGCCCCAGAAT
CCTAGCAACCCTTGCA
4 596 14969309 2992851 3674143 PSG6 PSG10 NM 001031850 1 -glycoprotein 6 ILMNJ 792434 TGGGAAACTATTCATGAGTATTC ATGAAGATGAGCAGAT (PSG6), transcript ATAGG CC variant 2, mRNA Homo sapiens major CAGAGCAATCTGCTGC
CTGCAGTCACTGACAGTGCCCA histocompatibility CAATAGAGTTTGGAGG
3818 1303 3351 315 18512 37900177 HLA-F ILMNJ 800253 GGGCTCTGGGGTGTCTCTCACA c£i524' HLAF' HLA' NM-018950 complex, class I, F TGGATATTTAGTTTACA GCTAAT (HLA-F), mRNA G Homo sapiens solute carrier family 25 (mitochondrial carrier, phosphate carrier), TCCTTCGACCTCCACTGCGCCC
MGC2615, MCSC2,
342 1127 0059 267 44763 405 18094 SLC25A23 NM 024103 member 23 CACCTCCCTGCCTGTGTGTGTT SCaMC-3, APC2 (SLC25A23), nuclear ATTTCA gene encoding mitochondrial protein, mRNA
Homo sapiens CTCTCTGTATGACAACTCTACAG
2 603 854 0643 273 59344 407 7726 AGA AGU, ASRG, GA NM_000027 aspartylglucosaminidas AAGTTGTGCGCGTGCTTTCTCA e (AGA), mRNA GCAGC
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe_Sequence Probejd Probe_Sequence_l
Homo sapiens pleckstnn homology domain containing, family A ATCCTTGTTCGATAGCATAGGAA
2 703 997 7101 35900595 3834268 PLEKHA1 TAPP1 NM 001001974 (phosphoinositidθ AATGTTCTGGTGATTGTCAGGG binding specific) TCTCC member 1 (PLEKHA1), transcript variant 2, mRNA
DKFZp686l10125, MLCK108, Homo sapiens myosin
AGAGCTGGAGAACTCCATGTAC FLJ 12216, light chain kinase
2 902 10260977 311 57263 4100393 MYLK NM 053032 TTTGGAATCTCCTCCAAGATAGC MSTP083, KRP (MYLK), transcript CAGAG MLCK210, smMLCK, variant 8, mRNA MLCK, MYLK1
CTGAGGAAGTATCTAG
Homo sapiens CAGGGGGAGTGAAACTTGGCTG CCTCCGTCCCCCTCGC
2289 833756 387 33093 34868512 KIAA0913 FLJ34302 NM 015037 KIAA0913 (KIAA0913), ILMN 1809582 GACAGATCATCCTCACTCAGTT CTGATCCATGAAGATG mRNA CCCTGG GC
CTPP3, SNF7, Homo sapiens AGCTGAAAGTGGGGGT
GTGTATTGGCCCTGTGTTTACC dJ553F44, chromatin modifying AAAGGTGGAGTAATCT
2236 863 1393 35821014 41741846 CHMP4B NM 176812 ILMNJ657436 ACTCTGGCCCACTCCTCACCCC CHMP4A, Shaxi, protein 4B (CHMP4B), GTGGATTTGTTTCTGTT CTTGCT SNF7-2, C20orf178 mRNA G
Homo sapiens
CCAACGACTAACCCTGAAATGG chromosome 10 open
2776 921 35596 2589268 42662262 C10ORF56 FLJ90798 NM 153367 GGGTGTTCCAGCCTTCAGCGAG reading frame 56 ATGGCC (C10orf56), mRNA Homo sapiens
GCTGTTTGTGGCAGGAACCCCT
B5R 1, NQO3A2, cytochrome b5
2061 7792893 324 7393 43938928 CYB5R1 NM_016243 GGCTGTGCAAATAAATGGGGCT humb5R2 reductase 1 (CYB5R1), GAGGCC mRNA
Homo sapiens small nuclear
SNURF-SNRPN, GCTCCATCTACTCTTTGAAGCTT ribonucleoprotein
2291 8724393 32981427 4397976 SNRPN HCERN3, SMN, RT- NM_022806 CTGCCCAGCTTGCATTGTTTCTA polypeptide N
Ll, SM-D, SNRNP-N GGAG (SNRPN), transcript variant 3, mRNA Homo sapiens GDP- TCAGTCACATTCGCTTC
CCTCCAGGGTTTGGGTCGCTTT mannose 4,6- AGTCCTACGGGCGAGT
2 591 961 0893 30560596 44905594 GMDS GMD NM 001500 ILMNJ 675188 GCGTTTGTCGAAGCCTCCTCTG dehydratase (GMDS), GGACGGAGGGCTTGCT AATGGC mRNA G
Homo sapiens
RSK3, S6K-alpha, ribosomal protein S6 TTTGTATTTTAAGAGTC
S6K-alpha2, GCAGCATCTGTGTCGTTCTACT kinase 9OkDa, TCATGCTCTACCGTTG
6 109 22553892 375 15594 37885178 RPS6KA2 PP90RSK3, HU-2, NM_001006932 ILMNJ 683305 GAGCACGCTTCTCTGCCTCGCT polypeptide 2 GAACTAGCCAGATGGC
RSK, MAPKAPK1C, CCTGAC (RPS6KA2), transcript C
P90-RSK3 variant 2, mRNA
Fold change XS pOS+6GF pOS Common Synonyms Geπbank Description Probe_Sequeπce Probejd Probe Sequβnce l
Homo sapiens TACCCTTCATGAGACC
CAAGGGTCCAGAGAAGGAGGA nicotinamide N- CAACTCTGCCACAGCT
4 391 1307281 4596601 191 45178 NNMT NM_006169 ILMNJ 697975 GAAGTTGAGACAGGCGGTCAAG methyltransferase CATCCTCGGAGGCAAT CAGGTGC (NNMT), mRNA CC Homo sapiens
AGACTACAGCTGGATA interleukin 11 receptor, GCTGCCCTTTAAGCCT TGCATGTATGTAGGTGCCTGGG
2 496 1077 231 459 38928 40590594 IL11RA MGC2146 NM_004512 alpha (IL11 RA), ILMN_1801869 GAGTGTGTGTGGGTCCTTGGCT
TGGAGATGGGGAGGAT transcript variant 1 , CTTGGC CC mRNA
Homo sapiens WD CACCTGTGCTTGATGTCAGCTT
2 178 948 07263 47087262 4039226 WDR13 pUk^^MGΣi ' NM-017883 repeat domain 13 CAACTGCGACGAGAGCCTACTG
(WDR13), mRNA GCCTCC
MGC126191. GE, Homo sapiens GCCCCAGGAGAAGCCC CD236R, GYPD, g ycophorin C (Gerbich CAGTCCTTGGAAAAGG GGGCAGTGCAGGACAACATCAG
3634 13997144 31493512 48368094 GYPC CD236, GPC, NM_016815 blood group) (GYPC), ILMNJ 693961 CTCACTGGCAGGAAAGTCCTTG
TGGATGAGAAGTAGCT
MGC 117309, transcript variant 2, TTGAGG GG MGC126192 mRNA
CCCTTGATGCTGGGGC
Homo sapiens
NGBE, PPCA, GSL, ATccGGGTTGGGATGG
2 336 10283392 49506012 392 50595 CTSA NM 000308 cathepsin A (CTSA), PPGB, GLB2 AGATAGGAGGATCTCA mRNA
GT
TBC1D11. RP11- Homo sapiens RAB GTPase activating
4842 21639226 437 1643 464 83093 RABGAP1 DKFZp586D2123 NM_012197 protein 1 (RABGAP1),
GAPCENA mRNA
Homo sapiens pregnancy specific beta
6518 21844226 22878094 507 6976 PSG4 PSG9 NM 002780 1 -glycoprotein 4 (PSG4), transcript variant 1 , mRNA
Homo sapiens laminin,
357 1616 5642 504 18927 411 81012 LAMB2 LAMS NM 002292 beta 2 (laminin S) (LAMB2), mRNA
Homo sapiens chromosome 3 open
2024 9390768 522 9643 41563095 C3ORF21 FU35155 NM 152531 reading frame 21 (C3orf21), mRNA
Homo sapiens chromosome 20 open
2 878 13553726 422 8518 5292018 C20ORF108 ^gyH^"^ NM_080821 reading frame 108 (C20orf108), mRNA
H°m0 / faf'e "S , , „ TGTCCAGAGGGGGTTC Phosphat,dyl,nos,tol-4- TGCCCCTTGTGAAGGC
2225 10767101 467 8018 50581012 PIP5K1C
Figure imgf000145_0001
NM-012398
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe Sβquencβ Probejd Probe_Sequeπce_l
GCCTATAAACAGATTGA
Homo sapiens TEA AGTGGGTGCTAGGGTCTTGACT
TGCACGTGGTGGGAAC
2 783 1310 7559 411 2143 545381 TEAD2 ETF, TEF-4, TEF4 NM_003598 domain family member CCTGAGCTAGTAGCCT ILMN-1692276 TTATCTCCGCTGCACAAGCAGT 2 (TEAD2), mRNA GTGTTG
T
Homo sapiens GGCCTGCCAGAGTGTG
CGGAACATATCCAGTACTCCTG interferon gamma GTTTGTGGTCCCATTTC
2 008 981 66016 5362476 4502768 IFNGR1 FLMWM^^ NM_000416 receptor 1 (IFNGR1), AGGGGGAAGATACTTG ILMN-1675428 GTTCCTAGGTGAGCAGGTGATG
CCCCAG mRNA A
Homo sapiens Rab CTGACTTCTGAGCAGG
MGC105128, CCCACAAACGGAGGCCAGACTT interacting lysosomal TGAGGAAGCACTACCT
2688 13186477 4807268 507 05594 RILPL1 FLJ39378, NNM78314 CTGCGTTAACTTCAGTAACACAA protein-like 1 (RILPL1), GAGTGGGGGACCCGA
MGC99793 GCTTC mRNA
Homo sapiens collagen, type VIII,
6745 27688975 311 96844 5586268 COL8A1 C3orf7, MGC9568 NM_020351 alpha 1 (COL8A1), transcript variant 2, mRNA
Homo sapiens kθlch
2017 10074435 561 65594 44582263 KLHDC2 LCP, HCLP-1 NM_014315 domain containing 2 (KLHDC2), mRNA Homo sapiens methyl- CpG binding domain
2 577 1201 631 5667351 39451843 MBD4 MED1 NM 003925 protein 4 (MBD4), mRNA
Homo sapiens zinc finger protein 580
2 359 12620726 49050177 5890851 ZNF580 NM 016202 (ZNF580), transcript variant 1 , mRNA Homo sapiens
SYNC, MGC149626, syncoilin, intermediate
3454 1572 8394 3864893 573 9518 SYNC1 SYNCOILIN, NM_030786 filament 1 (SYNC1),
MGC149625 mRNA
Homo sapiens NECAP
2 154 1219 7476 5345601 6024643 NECAP2
Figure imgf000146_0001
"^" NM_018090 endocytosis associated 2 (NECAP2), mRNA CCCTCT
Homo sapiens twist homolog 1 GTCTTCCCAGTTTCTCC
AGACGGGCAGCGGCACCATCC
(acrocephalosyndactyly AAGCTGCTTCTGGAAT 177BOR4
2 172 1101 1726 42647678 60331006 TWIST1 ™^' SCTBPESS NM-000474 TCACACCTCTGCATTCTGATAGA
3, Saethre-Chotzen GCAGGTCTGTCGGCTG -
AGTCTG syndrome) (Drosophila) G
(TWIST1), mRNA
Homo sapiens cyclin- dependent kinase 7
GGGCCAACACCTGGATGTCAGC (MOi 5 homolog,
2408 13904976 604 15594 5524643 CDK7 c^STK^^71 NM-001799 TGCCAAGACCAAACTGTCCAGT Xenopus laevis, cdk- GGAAAC activatmg kinase) (CDK7), mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probβ_Sequβnce Probe ld Probe_Sequeπce_l
Homo sapiens
CTCCCGTCTTCCTCCTCCCCTG cystathionine-beta-
6951 29992559 603 381 345 7143 CBS HIP4 NM_000071 GCAACTGCTGATCGACTTTGTG synthase (CBS)1 TCTCTG mRNA solute
TGGGAGGCTGAGGTGGGTGGA 35,
2 371 1298 3643 632 34766 4892351 SLC35E1 NM_024881 TCACTGGAGTTTGAGACCACCC TGGCCAA
Figure imgf000147_0001
mRNA
Homo sapiens
TATCAATTCTGCTGTGT microtubule-associated CCCTCTTTAACACAAGGGCCCT TCCCTGGCCTGCAGGG
2228 12152393 4592851 651 85596 MAPRE2 RP1, EB1, EB2 NM_014268 protein, RP/EB family, ILMNJ 743784 CCTTGTCATTGACCTTAGCTAAA AGGTCCCCACAACCAC member 2 (MAPRE2), CCATG G mRNA
Homo sapiens tyrosyl- DNA CTGTATTAAAAAGGCAAATCGAA
2041 1160206 631 19763 52465594 TDP1 MGC104252 NM_018319 phosphodiesterase 1 GGCCGGGCGCGGTGACTCACG (TDP1), transcript CCTGTC variant 1 , mRNA
Homo sapiens ub,qu,t,n
GAGACTCTGTTTATCACTAGCCT T" AAGGCCAGGTCACCTA
261 1601 3477 661 8726 5709351 UBE2E2 UBCH8, FLJ25157 NM_152653 E2E 2 (UBC4/5 CAAAGGGAAGCCCTTC ILMNJI 815447 TCTGTCCCTCCCGCAGAAGACT homolog, yeast) GTTGG (UBE2E2), mRNA
Homo sapiens TAP
GGTGAGCCATGGAGCC binding protein CGCCGCGCGTCCCTCTTGTGC CCTCTTATCTGGGCCC
2311 14264309 56969763 66949347 TAPBP TpSN NM_003190 (tapasin) (TAPBP), ILMNJI 750497 GGTTCACCACAGTTGTATTTAAG AACCTCTCCTTAAATAA transcript variant 1 , TGATCG C mRNA
Homo sapiens peptidylprolyl CCGTCACCCTTTAGTTTGCTTGA
3 177 1713 3309 673 5226 4337893 PPIC MGC3673, CYPC NM_000943 isomerase C ACTTTAGTAAACCACCTGCTTAG (cyclophilm C) (PPIC), GGAC mRNA
Homo sapiens
PRO2160, FP504, maternally expressed 3
CTAGGGGAGCTGTTGAGCCTTC -002766 (MEG3) on
5 503 2774 3145 69501013 3776101 MEG3 s AGTGTCTGCATGTGGGAAGTGG chromosome 14 GCTCCT
FLsJ425c89, P1R'O0518 NR XRJ001346- XR_001372 Homo sapiens CAGCTCCGTCCCCAGCGCTCAT
2 937 15196643 37549762 7059518 EVL RNB6 NM 016337 Enah/Vasp-hkθ (EVL), GGTGTTGAAACTGTCTGTCATG mRNA CACCAC
Homo sapiens UBX TCTGCCCTCCTGACCTTCTCGT
2 133 1307 4727 52586426 714 22266 UBXD1 uBXD^?D1°9 NM_025241 domain containing 1 GGGACATGGCTGTGCTGGAGG (UBXD1), mRNA ACATCAA Homo sapiens CCCATAATACAGGGGG
AATTACTATGTTCGGGCCGTCC cytochrome b-245, AGCCACTTGGGCAGGA
3551 20206975 4442768 72890594 CYBA NM 000101 ILMN 1657571 TGCATCTCCTGCTCTCGGTGCC alpha polypeptide GGCAGGGAGGGGTCC CGCCGG (CYBA), mRNA ATT
Fold change XS pOS+βGF pOS Common Synonyms Genbaπk Description Probe Sequence Probe Id Probe_Sequence_l
Homo sapiens
DKFZp686F18175, phosphatase and actin GGGCTTAACTTTACCTC TGCATGCCCAGGTGTCTGTCTC
2 164 14598976 626531 729 381 PHACTR2 KIAA0680, C6orf56, NM 001100164 regulator 2 CTTGAAAATGACATGGA ILMN_1685521 TGGCTGAGGTTTTGTCTATTTTA MGC176642 (PHACTR2), transcript CTTGGGTGGATGGTTC CAGTG variant 1 , mRNA
Homo sapiens CXXC TCTGGCCTTGCTAATGGCAACA
625 3251 3726 354 35596 768 3393 CXXC5 HSPC195 NM 016463 finger 5 (CXXC5), GAAGAAAGGGCTTCTTTGCGTG mRNA GTCCCC
Homo sapiens myosin, TGAGCCACGTTATCTC
LC20, MYRL2, AAGAACCCCACAGACGAATACC light chain 9, regulatory GGCGCTGGTTTCCGAG iβqβiβq
4 583 33444976 7730893 6958143 MYL9 MRLC1. MLC2, NM 006097 TGGAGGGCATGATGAGCGAGG
(MYL9), transcript TACCGCTGAACTGTGG "-MN-l bbbl BJ MGC3505 CCCCGGG variant 1 , mRNA GT
Homo sapiens microtubule-associated ACATGCTTGGGTTGGA
CCCCTCGGTCTCCACGTGGTGT protein 1 light chain 3 GCGCAGCAGTAAACAC
7436 5120 1475 6526018 74748096 MAP1LC3A ^Ip!"^1 NMJ81509 ATGGATCTGTGGTCATTGTCCC alpha (MAPI LC3A), CCTGCCCAGTGACCTG ILMN-1 "M^aJ TCTGCA transcript variant 2, GA mRNA
Homo sapiens collagen, type VIII, GAGACCGGGTGTTCCTCCAGAT
627 39680977 488 99762 8535768 COL8A1 C3orf7, MGC9568 NM_020351 alpha 1 (COL8A1), GCCCTCAGAACAGGCTGCAGGA transcript variant 2, CTGTAT mRNA
Homo sapiens damage- CACTGAGAACGCCTGC
CTTCTGCCTCACTTCGAGCAGA regulated autophagy CAGCTTCCCCATGCCC
8825 6043756 639 76013 771 506 DRAM FLJ 11259 NM 018370 CTTTTGTTCTCGGCGCTCCTCA modulator (DRAM), TCACTTGGTTTGTGTTT "-™™-"u'*" CGATGG mRNA T
Homo sapiens
CCCAGAGCACTTTGCAACTCCC
HLF, ECYT4, HIF2A, endothelial PAS
9342 57787646 44989343 870 7643 EPAS 1 NM 001430 TGGGTAAGAGGGACGACACCTC MOP2, PASD2 domain protein 1 TGGTTT (EPAS1), mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probe Id Probe_Sequence_l
Homo sapiens major histocompatibility complex class I HLA- A29 1 (HLA-A29 1), mRNA XM_001132736 XM_001132742 XM_001132747 XM_001132750
GGCGTTGATTTCAACC XMJD01132753 ACGGACGCCCCCAAGACGCATA CTCCTTCACTCTGGCTT
3 176 23192476 611 23096 B71 58923 HLA-A29 1 NM 001080840 XM_001132757 ILMN_1721106 TGACTCACCACGCTGTCTCTGA
CTTCAGGCAACCACGT XM_001132760 CCATGA
G XM_001132769 XMJ301132772 XM_001132776 XM_001132779 XMJJ01132781 XM_001132783 XM_001132785 XM 001132794
CGI-151. PNCA1, Homo sapiens palladia
GCACCGGGTGGCAGATGTTCTA KIAA0992, cytoskeletal associated
3791 5393 6296018 810 3393 PALLD NM 016081 TGCAGTGTGGTTCAAGTTTCTTT FLJ22190, SIH002, protein (PALLD), GACCG FLJ38193, FLJ39139 mRNA
Homo sapiens
CAGCATGTCAGGCCAG potassium channel GCCCAGGAAGGTTAGATGTGTT
MGC14254, GATTATTAGGGAGATTC
5754 39052144 52365594 8907434 KCTD20 tetrameπsation domain ILMNJ 753016 TGCAAATAAGTTGCCCAAAGGG dj108K11 3, C6ort69 NM-173562 CTCGAAACTAGTGTGT containing 20 TCCCCC G (KCTD20), mRNA
Homo sapiens solute carrier family 25 (mitochondrial earner,
GCATTGTGGCTGTCAAATCCAT citrate transporter),
2608 19044559 5766476 9254143 SLC25A1 SLC20A3, CTP NM 005984 GTGTCCCCCCTGTGGTCTGTGT member 1 (SLC25A1), GTGACA nuclear gene encoding mitochondrial protein, mRNA
Homo sapiens 6- CCGCCTCCTGACCGTGCCCTTC
2 858 24969392 792 84766 96997266 PGLS 6PGL NM 012088 phosphogluconolacton GAGAAGCATTCCACTTTGTAGC ase (PGLS), mRNA TGGCCA
Homo sapiens poly
ADPRT3, ADPRTL3, (ADP-πbosβ) TGAGGTCAACGGCAGA
CTGTGCCTGGCTTATTTCACTCA pADPRT-3, polymerase family, GACTTATCCAGAGCAA
248 2100885 792 8393 922 5476 PARP3 NM 005485 ILMN 1742949 GCATAATGTGCACCGGGTTCAC ADPRTL2, IRT1, member 3 (PARP3), CTCATGACCAGGCTGT CCATG hPARP-3 transcript variant 2, GG mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe_Sequence Probejd Probe Sequence l
Homo sapiens solute
MPE16, CD98, carrier family 7 CTAAGTACGATGTTCAA
AGGCTGGACACCCTCTGCCGAG 4F2LC, hl_AT1, (canonic amino acid GTGAGAGCAGCAGTGA
2 7 2167 9226 1081 0642 591 46844 SLC7A5 NM 003486 ILMNJ 756455 TAATGACGTGTGTGGCTGGGAC D16S469E, LAT1, transporter, y+ system), GCTCCATGTGCAGAGA CTTCTT E16 member 5 (SLC7A5), G mRNA
Homo sapiens milk fat CCCTGTGGAATTCAAC
GGGCCCTCATGCTGGCTTTTCA
HST19888, BA46, globule-EGF factor 8 CCCAACTTCGTGGCGC
7 973 5290456 8059435 692 23096 MFGE8 NM 005928 ILMNJ 690802 CCCCAGAGGACACAGGCAGCTT OACGD3S, EDIL1 protein (MFGE8), GTATGATACCTAAAGTG CCAAAA mRNA G
FLJ32603, Homo sapiens inlegrin
GCTGTGGAATGCGTGTTTGGGT DKFZP761D0211, alpha FG-GAP repeat
2707 26535728 84420593 1145 1393 ITFG3 NM 032039 CAGTCTGTGCCCTCTCAGTAGA gene +108, C16orf9, containing 3 (ITFG3), CACTGG gs19 mRNA
PREDICTED Homo CAAATGTGCCTTCTCCT
TCTCCGCTCTGACTTGTGGCTC sapiens radical fringe CCCAGGAACCGTACTT
2 103 2163 031 9242893 11559559 RFNG XM 001132711 ILMNJ677920 AGGACTACTTTCTGGGTCGTGC homolog (Drosophila) CAGCTACTCTGGTGCC TCCTGC (RFNG), mRNA T
Homo sapiens solute CCTAGCTGCTCGGGAG
FLJ44586, GCACACCCCTGCGTGTAACTGC carrier family 44, GCTGAGGCAGGAGAAT
3236 3082 1143 7755893 1171 8477 SLC44A2 DKFZp666A071, NMJ320428 ILMNJ 772492 ATTCCAACCACTAATAAAGTGCC member 2 (SLC44A2), CTCTTTCTTAATTGGCC
PP1292, CTL2 TATTG mRNA A
Homo sapiens major histocompatibility GGCAACAGTGCCCAGGGCTCT
3775 38399893 8706809 11904976 HLA-H NR 001434 complex, class I, H GATGTGTCTCTCACGGCGTGAA (pseudogene) (HLA-H) AGTGTGA on chromosome 6
Homo sapiens hKIAA1049, NULP1, GGGAGTGGGACTGAGCGTCCG transcription factor 25
2289 24537642 9998893 11634309 TCF25 PRO2620, HuIpI, NM_014972 CAGAGGTGACCGAAAAGCCGTA (basic helιx-loop-he!ιx)
FKSG26, KIAA1049 TGATGAT (TCF25), mRNA
Homo sapiens
GGTTCTGCCTTCCAGT
PC2, PKD4, APKD2, polycystic kidney ATTTGAAGTGCAGCTATTATGTG ATGAGTATGAGCCACC
2 544 2831 0142 101397266 1241 3142 PKD2 MGC138468, NM_000297 disease 2 (autosomal ILMNJ 716480 GTATCCATGTGTATCGACCATG CTGCACGTCCCTCTGT
MGC138466 dominant) (PKD2), TGCCA GC mRNA
Homo sapiens cytochrome c oxidase ACCGCCCGGAACCGCTTTCAGA
COX7AH, COX7A,
3719 34546143 933 5226 1049 9976 COX7A1 NM 001864 subunit Vila ACCGAGTGCGCGAGAAACAGAA COX7AM polypeptide 1 (muscle) GCTCTT (COX7A1), mRNA
Homo sapiens AT rich CCCTGGGGAAATTGAT
GTCCAGTGTTGGCTGTTAGTGT
MRF2, FLJ21150, interactive domain 5B GGGTGTGGCAGTGGAC
429 45157896 79822266 1382 156 ARID5B NM 032199 ILMNJ 674941 ATTTGATATTCTGCCTGTCTCCT RP11-341A19 1 (MRFMike) (ARID5B), CTGTGAAGAGGGAGAA CATGG mRNA TC
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe_Sequence Probejd Probe SequenceJ bA216L13 10, CGI-
Homo sapiens TGCAGGACAATGCTGC 202, PHP14, CGGGCGCATCTCCCACCAGAGT phosphohistidine CAGAGGCCTGGTCCTC
2673 3480 1892 13322101 1281 581 PHPT1 HSPC141 , RP11- NM_014172 ILMNJ 713038 CAGGACAAGAAGATTCACGTGT phosphatase 1 AGAGCTCACGTAAGCA
216L13 10, ACGGCT (PHPT1), mRNA TC DKFZp564M173
Homo sapiens CTGGATTTCACCTTCTT
GGTGAGCTGAGATCACACCACT chromosome 10 open GCACCTGCCGCGACTG
2474 32126895 1162 9644 1448 3684 C1OORF58 MGC4248 NM 032333 ILMNJ 762290 GTATTCCAGCCTGGGTGACTGA reading frame 58 CAGGAGCTTCACCTGC GACTCT (C10orf58), mRNA A Homo sapiens GAATACTTCTCTTGCTGAGAGC
3591 4711 5977 1473 1477 11802144 SELM MGC40146, SEPM NM_080430 selenoprotein M CGATGCCCGTCCCCGGGCCAG (SELM), mRNA CAGGGAT
Homo sapiens inhibitor of DNA binding 2, GCAGACTTTGCCTTTTTTCAAAG
GIG8, MGC26389,
3454 4553 106 10984476 1577 1643 ID2 NM 002166 dominant negative helix GTGGAGCGTGAATACCAGAAGG ID2A, ID2H loop-helix protein (ID2), ATCCA mRNA
Homo sapiens signal recognition particle
AGGAGGGCCTGGGTTT 14kDa (homologous TGCCGGACGTTGGGCAGCGTC GGGTTCTTTCCTCCCA
2428 3459831 14026101 14636809 SRP14P1 NR 003273 AIu RNA binding ILMNJ 805999 TATATCACCTTGAAGAAGTATGA GCCTTTGGATGGTGCC protein) pseudogene 1 TGGTCG (SRP14P1) on chromosome 12
SULF-1. FLJ30905, Homo sapiens CCTCACTGAGTCATCAGTACCC
795 7588456 1203 1143 1023 1601 SULF1 KIAA1077, HSULF-1, NMJ515170 sulfatase 1 (SULF1 ), TCCTATTCAGCTCCCCAAGATG
FLJ38022, FLJ41750 mRNA ATGTGT
Homo sapiens GCCCTCCTGCATTGCTGCTGCG
45 52690728 834 1726 1621 3143 PGM1 NM 002633 phosphoglucomutase 1 TGGGTATTTGTCTCCTTAGCCAT (PGM1), mRNA CAGGT
PRDX6, AOEB166, Homo sapiens MGC142285, B166, peroxiredoxm 5 TCCCACTCCGCCACCT
GGCCAAGGGAGTCCAGGTGGT PRXV, PLP, (PRDX5), nuclear gene CCGTCCACACCTCGGT I 71 K1 10
2 033 3110456 14802643 1591 8477 PRDX5 NM 012094 GGCCTGTCTGAGTGTTAATGAT MGC117264, encoding mitochondrial CTGATGGGCGAGAAAT ILMN-17151 10 GCCTTTG SBBI10, ACR1, protein, transcript AT PMP20, MGC142283 variant 1 , mRNA
Homo sapiens zinc GATGGGGTACTGCCGGTCTGTG
MGC51082, Zfp428,
2051 3227 5562 14292142 17359976 ZNF428 NM 182498 finger protein 428 TTGTCTTAGAAGTAGATGTGTGA C19orf37 (ZNF428), mRNA TGGCC
Homo sapiens amino-
AGTTCCAGACACCTCCACGCCC tβrmiπal enhancer of
2 114 33897144 14654893 17706726 AES AES' ESPI ^ES-I NM-°°113° ACCTGGTCCTCTCCCATCGCCC split (AES), transcript ACAAAA variant 2, mRNA
Fold change XS pOS+βGF pOS Common Synonyms Genbank Description Probe Sequence Probe Id Probe_Sequence_l
Homo sapiens myosin, CCAGCTGTTGAAAGGA
LC20, MYRL2, CGTGTATCCCCACACAAATGCA light chain 9, regulatory TGCTCTCTGCTCGTGC
3995 6401 539 16774559 1535 5059 MYL9 MRLC1, MLC2, NM_006097 ILMN_1682959 AGCTCACCAAGGTCCCCTCTCA (MYL9), transcript CTCAAACGCTTGGATT
MGC3505 GTCCCC variant 1, mRNA CT
Homo sapiens
GGCCAGGGGGGTCTTT TAACGCCTGCAACGACATGGGT chromosome 12 open
2 059 34396978 1887 9392 1482 3976 C12ORF57 C10, GRCC10 NMJ38425 CTGCACCTTCATCCTTA ILMNJ 800976 AAGATGCTGCAATTCGTGCTGC reading frame 57 ATATGTCACAGTTTGTG CCGTGG (C12orf57), mRNA
O-Fuc-T, 0-FUT1 Homo sapiens protein
AATAATAGCCAGGCGTGGTGGC O-fucosyltransferase 1
2 318 3634 3726 1921 4727 1301 1892 POFUT1 MCKΪ2482 ^^ ' NM-015352 ACATGCCTGTATTCCCAGCTGC (POFUT1), transcript TTGGGA
KIAA0180 variant 1 , mRNA
Homo sapiens 3'- phosphoadenosme 5'- CAAGGTTGCCACAGCT
TGCCCTGTCTACACCAGACAAC phosphosutfate CCCACAGCCCTTCCTA
3 199 6652 139 19667476 22189143 PAPSS2 SK2, ATPSK2 NM_004670 ILMNJ 748378 ACAGGAGCTGGGTCAGATTCCC synthase 2 (PAPSS2), CAAGCACCTATCATTG CTCAGC transcript variant 1 , GG mRNA
Homo sapiens glioma
ACGCAAGTACAAGGTGAAGCTG tumor suppressor
2 119 4794856 21784644 2355781 GLTSCR2 PICT-1, PICT1 NM_015710 GTGGAGAAGCGGGCGTTCCGT candidate region gene GAGATCC 2 (GLTSCR2), mRNA
TATGACCGACAAGGCACCTCCT
4771 8031 806 1200 1143 24240642 CAMK2N1 NM_018584 dependent protein ILMNJ661627 GGTGTCTAACTCCCCCAAAGAC AATGAG
Figure imgf000152_0001
Homo sapiens protβasome (prosome, GACAGCCACCAGTAGG
PA28A, MGC8628, ACCGGGACATCCGGCTGATGGT macropain) activator CTTGGCAGTGGGCTGC
2425 4818414 16154268 2451 0059 PSME1 PA28alpha, NM_006263 ILMNJ778213 CATGGAGATCCGCAATGCTTAT subunit 1 (PA28 alpha) AGTGGAAATCAACTCAA
REGalpha, IFI5111 GCTGTG
(PSME1), transcript G variant 1 , mRNA
Homo sapiens insultn-
GCAACTCCAGACTGAGGTCTAC tike growth factor
464 11292 197 1881 5393 3151 906 IGFBP6 IBP6 NM 002178 CGAGGGGCTCAAACACTCTACG binding protein 6 TGCCCA (IGFBP6), mRNA Homo sapiens calponin GTGGCCTGTGGACATTTAGGCC
2 031 6157 3394 2852 9644 3228281 CNN3 NM 001839 3, acidic (CNN3), TGGGTGATGCATTTGCTCTTCC mRNA TGTTTG
Homo sapiens collagen, type III, alpha
TCAACTGCTTGTAAAGGTGCTC 1 (Ehlers-Danlos
6316 16732 38 29038477 24757393 COL3A1 FLJ34534, EDS4A NMJ3OOO9O CTC I I I M I CTTGTCATTGCTGG syndrome type IV, TCAAG autosomal dominant) (C0L3A1), mRNA
Fold change XS pOS+6GF pOS Common Synonyms Genbank Description Probe Sequeπce Probe Id Probβ_Sβquencβ_l
Homo sapiens calpain,
CDPS, 3OK, CANPS, TCCCCTGTACCTGTGCCAAGCC small subunit 1
2 198 7367 8896 34369976 32838977 CAPNS1 CANP, CAPN4, NM_001003962 TAGCACTTGTGATGCCTCCATG (CAPNS1), transcript
CALPAIN4 CCCCGA variant 2, mRNA
PRDX6, AOEB166, Homo sapiens
MGC 142285, peroxiredoxin 5
AGAAGAATTGGTGTTAA GGTGTCCATCTTTGGGAATCGA
SBBI10. ACR1, „, (PRDX5), nuclear gene
2665 10477 322 3785856 4087 1978 PRDX5 AAATGCTTCACCTATAT ILMNJ 672935 CGTCTCAAGAGGTTCTCCATGG
MGC142283, B166, NM-181652 encoding mitochondrial CTACTTTATTCAACGA TGGTAC
PRXV, PLP, protein, transcript
MGC 117264, PMP20 variant 3, mRNA
GAAGAGTAACAAGAGT
GCCTTGGCAGGGCACAATGACC Homo sapiens cystatin AGACTGGACCAGAAAT
2 105 8538 164 38306558 43156562 CST3 MGC 117328 NM 000099 TTGTCGAAATCCACCTGTCAGG C (CST3), mRNA CGGAGGGTGGCAAGCA "-1^"-1 ACGCCT
GC
Homo sapiens interferon induced GATCTTCCAGGCCTATGGATAG
4339 19777 998 3910656 5335006 IFITM3 1-8U, IP15 NM 021034 transmembrane protein ATCAGGAGGCATCACTGAGGCC 3 (1-8U) (IFITM3), AGGAGC mRNA
Homo sapiens glutathione peroxidase AGGCTCACTTGCCTTT
AGTTCCTCATCGACAAGAACGG
PHGPx, snPHGPx, 4 (phospholipid GGCTTCCTGTTGACTT
2784 14078605 42566895 60135645 GPX4 NM 001039847 ILMN 1723843 CTGCGTGGTGAAGCGCTACGGA snGPx, MCSP hydroperoxidase) CTTCCCGACCCAGAAA CCCATG
(GPX4), transcript GC variant 2, mRNA
Homo sapiens CTGACACTGCTCCGCATCCTGC
DKFZp686A15286,
2 328 13693 381 6412 4473 5429256 NUCB1 NM 006184 nucleobtndin 1 TGTGTGTCCTGTTCCATGTTCC NUC, FLJ40471 (NUCB1), mRNA GGTTCC Homo sapiens interferon induced TATCTTCCATTCCTCGCCCTGC
2 907 1643969 47062646 6769 831 IFITM2 1-8D NM 006435 transmembrane protein CCCCAGAGGCCAGGAGCTCTG 2 (1-8D) (IFITM2), CCCTTGA mRNA
TABLE 12
Fold
Synonyms Description Probe_Sequence Probe Id Probe_Sequence_l
Change XS No GFs pOS β GFs pOS No GFs Common Genbank
Homo sapiens collagen, type IV,
CAGATGTGTGCAATGTGGCAAACTGAAGC
MGC88184 alpha 6 (COL4A6), transcript TGCACAGTGTTGGTTTCCTTG
37 51 19409761 8228308 30635596 COL4A6 NM_001847 variant A, mRNA
Homo sapiens synaptotagmin-like GGGTCCCCAGCTTTGCCCCTG
MGC102768, CHR11SYT, GGGTCTGGTACCCTTGCAGGACCTTTGTA
2 (SYTL2), transcript variant e, GAGGTCTCAATCCTCTCTACAT ILMN_1766178 SGA72M, KIAA1597, SLP2 GGTTGTGGGAAAAAGTCGCAG
3572 51971423 8 50958 307 54346 SYTL2 NM_206929 mRNA TCTGAGG
Homo sapiens peroxisome
NR1C3, PPARG1, proliferator-activated receptor CCTGAGCCACTGCCAACATTTCCCTTCTT PPARG2 gamma (PPARG), transcript CCAGTTGCACTATTCTGAGGG
2067 157 86429 14 545191 301 20593 PPARG NM 015869 variant 2, mRNA
FOAP-13, EEG1, Homo sapiens solute carrier ACCGGGTGCCAGACTGAACTG
CCACCACCTTTGAGGACCTCGTGTCCCAA
PRO1659, family 43, member 3 (SLC43A3), CTTCCTCTTTCCTTCAGCTATC ILMN_1805216 AAGACTTTGCCTATCCCAGCA
DKFZp762A227. SEEEG-1 NM 017611 mRNA TGTGGGG
20 13 8392769 15095779 29800177 SLC43A3
Homo sapiens insulin-like growth GGCGGGGGCCGGGCTTGGAA
CACCTGAATGCGGAAGAGCTCGGCTCCC
IBP5 factor binding protein 5 CGATGTACGATACCCTCATAGT ILMNJ 665095 GTTTAGCATTTTGTACTTAAGG
17 95 12596923 83 18143 15205518 IGFBP5 NM 000599 (IGFBP5), mRNA GACCATTA Homo sapiens guaπylate binding AAACACAAGAAGTTCTCGAAAT
GCCTGTCCAGCTCCCTCTCCCCAAGAAAC protein 2, interferon-inducible GGGAGTTTGAAGACCTGGAAT ILMNJ 798129 AACATGAATGAGCAACTTCAG
13 17 12002893 12 185763 157 73929 GBP2 NM 004120 (GBP2), mRNA GGGGGAG
GGGCTTTGATGCCAGCATCCT
MAGI1 , RP11-486M3 1, Homo sapiens CNKSR family TGCATTTTGACCTGTTCAGTGTCTGTCTT
TGGATCAGTACTGAACTCAGTT ILMNJ810176 FU31349 member 3 (CNKSR3), mRNA CCAGCACGGTGTGTACACTTC
12 31 46498096 23201757 28602264 CNKSR3 NM 173515 CCATCCG
Homo sapiens chromosome 15
GCCTTTCCTCGCTCACCAGGC
FLJ22645, MGC32925, open reading frame 48 GAAGAGTTGCAAAATGTCCAAAGGGTGAC CAGTCTCAGGGCCTCACCGTA ILMNJ 800418 NMES1. FOAP-11 (C15orf48), transcript variant 2, CAAATGACGAGCCCTCGCCTC TTTCTACT
11 77 20017391 20217756 24525595 C15ORF48 NM 032413 mRNA
Homo sapiens collagen, type IV,
MGC42377, ATS, alpha 5 (Alport syndrome) AGCTCCAGCTGTGGTGATCGCAGTTCACA MGC167109, ASLN, CA54 (COL4A5), transcript variant 2, GTCAGACGATCCAGATTCCCC
11 38 257 87262 12 824924 141 45178 COL4A5 NM 033380 mRNA
GCTTGGACTATAGGTGCATGC
Homo sapiens annexin A10 ACTGCTTGCCATCTGTGCTGGTGATGCTG
ANX14 CACCATGCCTGGCTAATCTTTT ILMNJ771066 (ANXA10), mRNA AGGACTACTAAAATGAAGAGG
11 29 8 345976 9320261 107 30597 ANXA10 NM 007193 GCAGCGA
TCAAACTATTCTCTCCCGGGCT
Homo sapiens noggin (NOG), GGATTCCCATCCAGTACCCCATCATTTCC
SYNS1. SYM1 TAACAGCCTCGCAGCCCAGTC ILMNJ 812702 mRNA GAGTGCAAGTGCTCGTGCTAG
9797 11 755294 7983902 797632 NOG NM 005450 ACGGCCT
Homo sapiens bone AGACCGGTTCTGGAGACAAAA
AGTAGAGGGATGTGGGTGCCGCTGAGAT
BMP2B1. BMP2B, ZYME morphogenetic protein 4 (BMP4), GGGGCCGCGGCGGCCGGAGC ILMNJ 706440 CAGGCAGTCCTTGAGGATAGAC transcript variant 3, mRNA GGGACGGGC
7 792 190 57263 14412636 11028928 BMP4 NM 130851
TGCTTGCTCCCGAATCAGACG
RP5-11980202, Homo sapiens coiled-coil domain CCGGCAGCCAAACTTGTCCCC ILMN 1721440 AGGCCTCCACAAAGGCCTGGCAGACAGA containing 24 (CCDC24), mRNA TCCTGTAG GGTCTCATTCCAGCCTGACTCT
584 60 19111 6914125 40297394 CCDC24 MGC45441 NM_152499
MADH3, JV15-2,
HSPC193, MGC60396, TTCGATGATCTGCTCACATTCC
Homo sapiens SMAD family TGCAACTCGGCTGTTCTGGACTCTGATGT
Smad 3, HST17436, TGCTCTCTACCTACTTCTTGGT ILMNJ668498 member 3 (SMAD3), mRNA GTGTGGAGGGATGGGGAATAG
DKFZp686J10186, ATTCCG
5511 69948096 3782922 20658095 SMAD3 DKFZP586N0721 NM_005902
Fold
Synonyms Gβnbank Description Probe Sequence Probe Id Probe_Sequence_l
Change XS No GFs pOS 6 GFs pOS No GFs Common
IGFBP-rP10, FKSG40,
Homo sapiens Kazal-type serine GCTCAGAAGCTGGCAAATCTG
FKSG28, BONO1, CCTAAGCCCCAGTTGCACCTACTAACTGC peptidase inhibitor domain 1 GCTGTGACTTCAAGCATGCCC ILMN_1705865 bA108L7 1, FLJ24094, AGTCCCTTTTGCTGTCTGCCG
(KAZALD1 ), mRNA CACCAACC
5339 7372434 β 690823 46073246 KAZALD1 RP11 -108L7 10 NM_030929
Homo sapiens ST6 (alpha-N- acetyl-neuraminyl-2,3-beta-
SIAT7C, ST6GALNACIII, galactosyl-1 , 3)-N- TCACACCCATAAACATTACTAAGCCCCAG PRO7177 acetylgalactosaminide alpha-2,6- TTCTATCGTTGGAAGGAGTTG sialyltransferase 3
4767 54 187973 51 743732 24605594 ST6GALNAC3 NM 152996 (ST6GALNAC3), mRNA Homo sapiens synaptogynn 1
CAACCAGTGGCAGGTCTCCAAGCCCAAG
MGC 1939 (SYNGR1), transcript variant 1a, GACAACCCACTGAACGAAGGGA
4 705 142 46011 13921049 6550559 SYNGR1 NM 004711 mRNA
Homo sapiens retinoic acid
MGC8906, HRASLS4, GGCCACGGCGCTTGGAATCCTGGTTGTT receptor responder (tazarotene TIG3, RIG1 GCTGGATGCTCTTTTGCGATTA induced) 3 (RARRES3), mRNA
4467 109093445 15300022 680383 RARRES3 NM 004585
Homo sapiens nuclear factor I/C
CTF5, CTF, NF-I, NFI, (CCAAT-bmdiπg transcription AAGCCCCTCCCAAAGCGCCGGCCGACTC MGC20153 factor) (NFIC), transcript variant GCTGTCTCGCTGGGGACTCTTT
4444 7260902 14649551 6543894 NFIC NM 005597 1, mRNA
Homo sapiens transmembrane GTCGCTGAGAGTCCTGGAACTAACAGTCT
PRP2 protein 171 (TMEM171), mRNA GCTTCCGAATGAAAACCCCCC
4066 61 171288 26945152 110597626 TMEM171 NM 173490
FOAP-13, PRO1659, Homo sapiens solute carrier
TGGCTAGAGAACTCACAGCTCTGGGAAAA
DKF2p762A227, SEEEG- family 43, member 3 (SLC43A3), AGAGGAGCAGACAGGGTTCCC
4 035 45226368 37 3899 15084763 SLC43A3 1. EEG1 NM_014096 mRNA
DKFZP434B044, Homo sapiens cysteine-rich GCTCCTCACGGGCGATGGCTG
ACGGCGTTCCTGGCTCTCCTGCCCACAG MGC74865, CRISP11, secretory protein LCCL domain TCTTTTCTTGACTTTGTATCTTC ILMN_1671281 GATGAACATTTTCGGCTTCCTT LCRISP2 containing 2 (CRISPLD2), mRNA ACTGCC
3994 4729 881 221 51428 89223926 CRISPLD2 NM 031476
Homo sapiens major CACCGATGCCCCCATTTCACG
HLADM, RING6, DMA, CCAGAGTGGCCTGCCTATCACAACCACAT histocompatibility complex, class CCTGAGGAAGCGGAGGCTCAG ILMNJ731525 D6S222E CCCTTCCCCCCACAAGGCAAT II, DM alpha (HLA-DMA), mRNA ACGGGCCA
393 11831011 8 852243 344825 HLA-DMA NM 006120
Homo sapiens 1-acylglycerol-3- GCGCATGCACCTTCGTCAGTA
MAG1. AGPAT8, LPAAT- TCCTTGTTTGAATGCTGTAGATCTGTACC phosphate O-acyltransferase 9 CGAGCTGCTCTAAGAAGGGAA ILMN_1769191 thβta, GPAT3, MGC11324 TAGTACCCCTCCCATCTACTG
3909 32 390465 131 76845 516 86847 AGPAT9 NM_032717 (AGPAT9), mRNA CCCCCAAA
Homo sapiens insulin-like growth
IBP4, HT29-IGFBP, IGFBP ACCGGGATGAACCTATCCTTCCAGTGGCT factor binding protein 4 CGCTCCCTGTAGCTCTGCCTC
3892 16556098 1475381 57464473 IGFBP4 NM_001552 (IGFBP4), mRNA
Homo sapiens prostaglandin E CATGGCCGCCCTACGGAAAAT
GGGGCACTTAATGGTCACCTTGTAACAGT
EP4R, MGC126583, EP4 receptor 4 (subtype EP4) CACATCCACAGAGGCCAGGGC ILMNJ676880 TTTGTGTAACTCCCAGTGATG
3783 35385967 393032 15057262 PTGER4 NM_000958 (PTGER4), mRNA TACCCAAG vzg-1 , Gpcr26, Mred 3, Homo sapiens lysophosphatidic GGATAAGACCCCAGCAGCCCT
CTTTGTTTGAGGGACTCGTTATCCAGCTC βdg-2, red 3, LPA1, acid receptor 1 (LPAR1), GACATTTCTCCTCCACACTCCC ILMN_1678627 TTGGTAGCCACACCTGCAATG
LPAR1 transcript variant 2, mRNA CACTCAC
3744 2289 5225 75543933 2811 5645 LPAR1 NM_057159
TGAAGAACTCGACTTTATGTGA
Homo sapiens claudiπ 1 GTGCTATCTGTTCAGTGATGCCCTCAGAG
SEMP1, ILVASC, CLD1 TCATGGTATTGGTATACATGTG ILMNJ 763730 (CLDN1), mRNA CTCTTGCTGTTAGCTGGCAGC
3685 10022262 11 095724 40722214 CLDN1 NM 021101 GGGTGG
Fold
Synonyms Description Probe_Sequence Probe Id Probθ SequθnceJ
Change XS No GFs pOS β GFs pOS No GFs Common Genbank
Homo sapiens excision repair cross-complementing rodent repair deficiency, GGGGAGCCAGGAATGAGGCG
GATGAGAACGTAGACGCCAGTGGCTCAC
UV20, C0FS4 complementation group 1 GCAGCCGGGCCGTTTGGGCTC ILMN_1699854
TCGCTCCTGGCACCTTCCCTTT (includes overlapping antisense AAGACACAC sequence) (ERCC1), transcript
3526 7421506 90 10183 31673096 ERCC1 NM_202001 variant 1 , mRNA
Homo sapiens guanidinoacetate
ACGACACGTACCCACTCTCGGAGGAGAC
TP53I2, PIG2 N-methyltransferase (GAMT), CTGGCACACACACCAGTTCAAC transcript variant 1 , mRNA
3497 427 3393 104 85595 36805597 GAMT NM_000156
Homo sapiens follistatin (FST), TGGCTGTATCAGAGGGCTTTGAAAACATA
FS transcript variant FST317, mRNA CACTGAGCTGCTTCTGCGCTG
3489 60070377 98 82262 34551013 FST NM_006350
Homo sapiens follistatin (FST), AGAGGCCGGTGTTCCCTCTGTGATGAGC
FS transcript variant FST344, mRNA TGTGCCCTGACAGTAAGTCGGA
3 108 1123 1143 13769768 43076226 FST NM_013409
Homo sapiens lymphocyte
TSA-I1 RIGE1 RIG-E, CAGGGAGACCGTGTCAGTAGGGATGTGT antigen 6 complex, locus E SCA2, SCA-2 GCCTGGCTGTGTACGTGGGTGT
2 993 6349 1562 1811 281 54193975 LY6E NM_002346 (LY6E), mRNA Homo sapiens slit homolog 2 CTGACGGCTCCTCCTTTGTGGACGAGGTT
Sht-2, SLIL3, FLJ14420
2 931 63387256 1092 0476 31897642 SLIT2 NM_004787 (Drosophila) (SLIT2), mRNA GAGAAAGTGGTGAAGTGCGGC Homo sapiens solute earner TGTGACTCAGTGACCCGGAGG
GGGGATGGTGGTCTTTGCCTTTGCCACTA MGC9564, HCP1. PCFT family 46 (folate transporter), GCAAGCAGGACTGTGGGTGAC ILMNJ 658864 TCACGCCTCTCATGTTCACAG
2837 53823128 18275572 52 084 SLC46A1 NM 080669 member 1 (SLC46A1), mRNA ACCTTGTG
Homo sapiens proteasome
RING10, D6S216, (prosome, macropain) subunit, CTCCCTTGGAAGACAGGAGAG
AGGTCTCCTCTGGGAGGTCTTGGCCGAC MGC1491. LMP7, beta type, 8 (large multifunctional ATGACTCCCTTGGAAGACAGA ILMNJI 707005 TCAGGGACCTAAGCCACGTTAA D6S216E peptidase 7) (PSMBβ), transcript TGACAGCC variant 1 , mRNA
2803 441 19345 147 86429 41463513 PSMB8 NM_004159
Homo sapiens chemokine (C-X-C GCTCTGAGTGTCCACGGGTGA
SRPSOX, CXCLG16, SR- CCATACGGGTTGGTTTCACCTCCTCAGTC motιf) lιgand 16 (CXCL16), AGAAGTGAGTGTCCACGGGTG ILMNJ 651819 PSOX CCTTGCCTACCCCAGTGAGAG
2 758 101 52732 7 983549 21 970535 CXCL16 NM_022059 mRNA AAGAAGTG
GGTTTAAGGTCCCCCACTGCA
Homo sapiens somatostatin GCCAGAGTGTATTACAACAATCTGGAGAT
SRIF-2 CACCTTCCTCAAGTCATAGCTG ILMNJ 694653 receptor 1 (SSTR1), mRNA ACTAAATCTGGGGTTCTCAGG
2 725 9085647 29649762 8138059 SSTR1 NM_001049 CTTGCAG
CDW127, CD127, IL-7R- Homo sapiens iπterleukin 7 CTGACATTGAACCCAGTTGCTCAGGGTCA
2 67 621 13513 10463512 27890594 IL7R alpha NM_002185 receptor (IL7R), mRNA GCCCATTCTTACTTCCCTGGG
TGATCAGCTCTGAGGTGCAAC
Homo sapiens heat shock 7OkDa GTAACCACGGGGTCCATCTTTTACATCTG
Osp94, APG-1 TTCTTCACATACTGTACATACC ILMNJ 724544 protein 4-lιke (HSPA4L), mRNA GTACACACAACAGACGCTCAG
2 585 38244774 21 042715 54 5054 HSPA4L NM_014278 TGTGACC
Homo sapiens ATPase, class I, TGAGCGACATCCGTGCTGATC
FIC1, PFIC1, PFIC, TAAGATCCAGAAGCATCGCAAGCGGTTGA type 8B, member 1 (ATP8B1), ACAATACTGTCCTGCCAGGGC ILMNJ 814200 ATPIC, BRIC AGGCGGAGGAGCAGTGGCAGC
2 573 15898929 87 81048 225 97263 ATP8B1 NM_005603 mRNA GGCCAAGA
Homo sapiens chromosome 9
CATTGTGCCATCACAAACCTCGTTCCAGC bA522l202 open reading frame 103 CGCCTTGCCCATACTAGATTC
2 535 18095178 59047707 14991846 C9ORF103 NM_001001551 (C9orf103), mRNA Homo sapiens ST3 beta-
SIAT9, ST3GalV, galactoside alpha-2,3- GGAGAGGGGAGGTCACTCTTTTGATGGT SIATGM3S sialyltransferase 5 (ST3GAL5), GGCCCTGAACCTCATTCTGGTT
2 522 6440842 18 532312 46545357 ST3GAL5 NM 001042437 transcript variant 2, mRNA
Fold
Synonyms Description Probe_Sequeπce Probe Id Probe_Sequence_l
Change XS No GFs pOS 6 GFs pOS No GFs Common Gβnbank
Mart2, KIAA1051, Edr, Homo sapiens paternally
CGGAGGGAACTGCAGGGAGACCAACTTA RGAG3, MEF3L, Mar2, HB expressed 10 (PEG10), transσipt TTTAGAGCGAATTGGACATGGA 1 variant 1, mRNA XM_940378
248 28491112 443478 11006845 PEG10 NM_001040152
Homo sapiens phosphodiesterase 4B, cAMP-
DKFZp686F2182, GGTGCTTTGGCCCTAATAGCA speαfic (phosphodiesterase E4 TTCTTCTGAATGCTCCCGAACTACTGACT MGC126529, DPDE4, CTGGACAACACCACGACCACA ILMNJ 670807 dunce homolog, Drosophila) TTGAAGAGGTAGCCTCCTGCC PDE4B5, PDEIVB TGGAAACA
(PDE4B), transcript variant a,
2425 11009762 5800982 14135178 PDE4B NM_002600 mRNA
Homo sapiens thioredoxin TGCATCCGACACCCACCCCCT
THIF, EST01027, VDUP1 , CAGCCATAGCACTTTGTTCACTGTCCTGT interacting protein (TXNIP), CTTTGTGTACTTCAGTCTTGGA ILMNJ 698297 HHCPA78 GTCAGAGCACTGAGCTCCACC
2379 35498096 11159345 2654226 TXNIP NM_006472 mRNA GTTTGGA
Homo sapiens ADAM
CCTCTCCCCTCTCCCATTTTGC metallopeptidase domain 15 GGCTTCAAGAGGCGGGCGTGCCCTCTGG
MDC15 ACTGTGTGTCGATGCAATCTTC ILMNJ676526
(ADAM15), transcript variant 2, AGTCCCCTACCATGACTGAAGG GCTAGC
2316 26045596 115172615 26650595 ADAM15 NM_003815 mRNA
Homo sapiens family with
CTCAAGGCCAAGCTCACCCCTCAAGTGCT
RNS DMP4 sequence similarity 20, member CTCACACTCGGGACCTAATTC
2235 1178006 42256427 9458976 FAM20C NM_020223 C (FAM20C), mRNA
Homo sapiens tripartite motif- CTGCCCAGAGGTGGGAACTGGAGGAGTG
FLJ16558, FLJ10759 contaming 62 (TRIM62), mRNA GGCTGCAAGACTGAGCCTAAAT
2194 53406754 24186794 52910774 TRIM62 NM_018207
COUP-TFII, TFCOUP2, Homo sapiens nuclear receptor CCTTGAAAGGTGCAGTGGAAA
CTGTGGAATTTATTGGCAGCCAAGGAATG MGC117452, COUPTFB, subfamily 2, group F, member 2 TATTAAGGCAGATACCACTGGA ILMNJ 809597 TGTCCAAGACACATGCTGAGG SVP40, ARP1 (NR2F2), mRNA GGGCAGG
2176 23746143 16510226 35805142 NR2F2 NM_021005
Homo sapiens CXXC finger 5 TCTGGCCTTGCTAATGGCAACAGAAGAAA
HSPC195
2162 32513726 35435596 7683393 CXXC5 NM_016463 (CXXC5), mRNA GGGCTTCTTTGCGTGGTCCCC Homo sapiens pyruvate CCCAGCTTGCTTCCATGGCCA
ACGCCTGAAGCCGATGATTGGAGCAATC dehydrogenase kinase, isozyme ATCTAAGGGCAGAGAAGAATA ILMNJ 756811 CCAGCAGTGAACCCAGGGATGC
2149 6059512 43959152 9439763 PDK3 NM_005391 3 (PDK3), mRNA AAGTGGAG
Homo sapiens potassium channel ACCCCTGCTGGCGGATAGCAA
GTAGTAGGTGCTTTCCTGATCCCCTTTGC
MGC2376 tetramerisation domain GACTCTGTGGAGTTTGTTCAGT ILMNJ661717 GAGATGCTGTGGGTGCTAACA containing 14 (KCTD14), mRNA GGTACGG
2138 9965596 8669766 18563095 KCTD14 NM_023930
Homo sapiens component of
GCCCCTCGCCTTTATCCTGCCAAAGAGAG
FU22315, DOR1 oligomeric golgi complex 8 AGACGCTTTTCACCCTGGATG
2138 63865067 39669365 8471434 COG8 NM_032382 (COG8), mRNA
Homo sapiens pterιn-4 alpha- carbinolamiπe AAGCCCCTGTGAAGGACAACA
TGCTGCCAAACCTGAGGGCTGTGGGGTG
PHS, PCD, DCOH, PCBD dehydratasθ/dimenzation ccccTGCTTGGGAGAGAGTCc 744628 GAATGAGCTGGAAGGCCGTGAT cofactor of hepatocyte nuclear CATGTCCA factor 1 alpha (PCBD1), mRNA
2125 3387726 10267262 21837679 PCBD1 NM_000281 myO36, p29ING4, Homo sapiens inhibitor of growth GGATTCATCCTGGGAGAGGGGGCAAGGT MGC12557 family, member 4 (ING4), mRNA GGAATGCAGATAACTCACATGT
211 11983096 20483475 4327829 ING4 NMJ316162
CCCGGCATGCACCTTGTTTCC
FLJ13813, LPSB, hSP56, Homo sapiens selenium binding GCTCCGCTACCCTGGGGGCGATTGTAGC ATGTTGTCATCCTCCCATGGCT ILMNJ691790 SP56, hSBP protein 1 (SELENBP1), mRNA TCTGACATCTGGATTTGAACTC
2 091 87 69475 7 026443 14716523 SELENBP1 NM 003944 TCCCCTG
Fold
Synonyms Description Probe_Sequence Probe ld Probe SequencβJ
Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
Homo sapiens NAD(P)H
CCCCTTGCTCCTTGTCTGGCC
NMOR1, NMORI, DHQU, dehydrogenase, quinone 1 GGCACTGGTGG I I I I I TAGAAGTGTGGGAAATTCAGG ILMNJ 758229 DIA4, DTD, QR1 (NQO1), transcript variant 1, TCCACAATAGCTGACGGCTGG AAAACGAG
2087 8688406 5791 289 12071 939 NQO1 NM 000903 mRNA
Homo sapiens chromosome 19 CTGGGCTCTATCATATAGACAG
GGAGCCTGCCTCTTTCCCAAACTGCTCAT
FLJ41131, MGC103014 open reading frame 54 GCTTCTGATAGTTTGCAACTGT ILMN_1726161 TATCCTGTTACCCCACCCAGC
2081 7249823 22 777435 47467953 C19ORF54 NM 198476 (C19orf54), mRNA AAGCAG
Homo sapiens RGM domain
FLJ90406, MGC86970, AGGTGACTGCCAACAGCCAGCCCAATGT family, member B (RGMB), DRAGON CGAATCCAGAAATGCACCACGG
208 4244354 8054361 16760596 RGMB NM 173670 transcript variant 2, mRNA
Homo sapiens mitogen-activated ACAAGACTGGCAGAGGCTGGG
CCTAGTTCCTTCCTGGCCCCTCTCTCACT
MAPKAP3, 3PK protein kinase-activated protein CAGCCTGGGGCTGATGAAGCA ILMNJ 678899 GGCTGGGAAACCCTAGACCAT kinase 3 (MAPKAPK3), mRNA GAGATGTT
2 036 47302264 51867676 1055 8477 MAPKAPK3 NM 004635
Homo sapiens purinergic
GCAGTCTGTTCTTGGCTGGGTCAACTCTG
P2X4R, P2X4 receptor P2X, ligand-gated ion CTTTTCCCGCAACCTGGGGTT channel, 4 (P2RX4), mRNA
2016 137 04762 13435646 27 071133 P2RX4 NM_002560
Homo sapiens chromosome 8
AGCACTGCCCGATAGAACACGCCCGCCC
DSCD75 open reading frame 55 (C8orf55), TCACTGCTGTTCTTGCCTTACA
1 987 247 17262 309 56845 61468933 C8ORF55 NM 016647 mRNA
CATACGATGCTCCATCAGCCTT
Homo sapiens YdjC homolog TGGAACCCTCCCTACTCTGACCCCCTACA
MGC133160 ACCTAAAGCTACCAGAAAGGC ILMNJ 744146 (bacterial) (YDJC), mRNA GACAACCAAGCACTAATCCCC
1 987 141 7768 8305623 16541013 YDJC NM_001017964 TTTGGGC
Homo sapiens dipeptidyl- CGCGCTATGCCATCCAGCAGA
FLJ11387, FLJ22331, GACAGGCCCATATGCAGGCCCGGTTTGT peptidase 3 (DPP3), transcript AATTGAAAGAAGCCCACGACG ILMNJ 670595 DPPIII GATCCTGAGAGTCTTGCTGGAG
1 966 11872261 594431 11692262 DPP3 NM 005700 variant 1 , mRNA CCCTGCAC
Homo sapiens scavenger
TTCCCCCCACTGCTCAGAGAC
APC7, MSLR1. MSRL1, receptor class A, member 3 TCCACCGCCCGCAAGGTTAGGGCATAGA GGCGAGAACTATGTTGTGCTT ILMNJ678730 CSR, CSR1 (SCARA3), transcript variant 1 , GTTGTCTCCTTCCCAACACGGA CTGGACTC
1 965 127 942696 111 51428 21841428 SCARA3 NM_016240 mRNA
Homo sapiens RanBP-type and
XAP4, RNF54, ZRANB4,
C3HC4-type zinc finger CCCACCACAACACTCATCTGTCAAACACC RBCK2, UBCE7IP3, containing 1 (RBCK1 ), transcript AAGCACTCTCAGCCTCCCCGC C20orf18
1 933 63808093 1629226 315 93927 RBCK1 NM 006462 variant 1 , mRNA
Homo sapiens AT-hook AGCCGGACCCGCCTCCGCATC
TGGCAGCAGAGGCCTTTCCCTCAGACAA
RP11-8211 4, KIAA1968 transcription factor (AKNA)1 GGGTTGCGATGCCCTCTGCAT ILMNJ 736584 GCTACAAAGTGCCCAGGATGCC
1 921 2669268 63 78645 122689285 AKNA NM 030767 mRNA AGTTTCTT
FLJ4S605, dJ187J11 3,
ACAAGGTGCTAAAACAGGTTCA ESNA1 , Nbla00052, Homo sapiens nuclear receptor CTGTAGCCTGGGTGTACGTTTCACTCAAG CCCCGATACTGGCATCTCATC ILMNJ 716195 Nbla10993, ERAP140, coactivator 7 (NCOA7), mRNA TTCTCCTACTGAGGACTCTTG CAAGGCC
1 919 2346606 197 9643 380 1726 NCOA7 MGC88425 NM 181782 KILLER/DR5, TRICK2,
Homo sapiens tumor necrosis TRAILR2, TRICK2A, factor receptor superfamily, TTAGGCTTTGCTATATCCCCAGGCCAAAT KILLER, TRICKB, member 10b (TNFRSF10B), AGCATGTGACACAGGACAGCC ZTNFR9, TRAIL-R2, DR5, transcript variant 1 , mRNA
10495892 353 98926 678 1935 TNFRSF10B TRICK2B, CD262 NM 003842
Homo sapiens DnaJ (Hsp40)
GAAGATGACAGTCCTTGCTCTCAGGGAG
TIM14, TIMM14 homolog, subfamily C, member CCCCCACTTTAATGGGAGACTG 19 (DNAJC19), mRNA
1 912 895149 51 93021 9899762 DNAJC19 NM 145261
Fold
Synonyms Description Probe_Sequence Probe Id Probe SequenceJ
Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
Homo sapiens hypothetical
CCAGCCCTGCGTTTCCATTCTGCCTTCTC protein FLJ20489 (FLJ20489), AGAGTGCCCTTGCTGCACCCA
1 91 12941428 24 850315 47 346428 FLJ20489 NM 017842 mRNA
Homo sapiens ubiquitm-like ACTGAGTATGTTCATTGCCACC
UBA7, UBE2, D8, TCAATGGAGCCCCGGATCCCAAGCCCTG modifier activating enzyme 7 CCTGTCCTCCCCTGGGCACCC ILMNJ 721178 MGC12713, UBA1B CATTGTAAGCCCACAGTAGGCA
1 896 222 83095 8369144 15850397 UBA7 NM 003335 (UBA7), mRNA CTCACTT
Homo sapiens family with CCCATGGCAGTCAGGCAAAGT
MGC11034, FLJ45505, GGGGCCCTGGTAGGCTCCTTTAGAAGGA sequence similarity 107, member GTTGCCAGGACGTACTGAAAA ILMNJ 803609 MGC90261, C10orf45 CCATTTCTGTTCCTAGAGCTTA
B (FAM107B), mRNA TCAGCCAG
1 888 633 59766 42560596 802 59766 FAM107B NM 031453
GGCGGCAGAATGCCATCAAGT
Homo sapiens supervillin (SVIL), GTTTCCTGCAGCATTAGGTATGACTTGTT
DKFZp686A17191 GTGGGTGGCTGAGGAAGCAAG ILMNJ 765876 transcript variant 1 , mRNA CTGAGTACTGCTTCCGGTGCT
1 871 392 8601 2993643 5607351 SVIL NM 003174 GAGGCTTT
Homo sapiens phosphorylase, glycogen liver (Hers disease, ATCCAAAGGCCTGGAACACAATGGTACTC glycogen storage disease type AAAAACATAGCTGCCTCGGGG
1 862 6388143 204 75595 381 38095 PYGL NM 002863 Vl) (PYGL), mRNA
Homo sapiens transglutaminase 2 (C polypeptide, protein- CCGGGACCACACAGACAGGCT
AAGGGCGAACCACCTGAACAAACTGGCC
TGC, TG2 glutamine-gamma- GAGGACGACTTTATGACCAAG ILMNJ 700935 GAGAAGGAGGAGACAGGGATGG glutamyltransferase) (TGM2), AGCTGAAC transcript variant 2, mRNA
1 81 96826454 15535178 2808601 TGM2 NM 198951
Homo sapiens ADAM
GCGCCAGGTTGTCAATGGCCT metallopeptidase domain 15 CGGGATTGAGGAAGGTCCGCACAGCCTG
MDC15 CATGCTGGGACAGGCCAGGAT ILMNJ698185 (ADAM15), transcript variant 4, TCTCTGCTCAGTTGCAATAAAC TCACGTAA
1 809 1792456 82353516 14906477 ADAM15 NM_207195 mRNA
Homo sapiens ATPasβ, H+ transporting VO subunit e2 TCTGAGCCTCCGTCGCCCCTCCTGTTGG
ATP6V0E2L, C7orf32 (ATP6V0E2), transcript variant 1, GTAAGGGTGTTGAGTGTGACTT
1 8 537 5601 551 1476 992 11426 ATP6V0E2 NM 145230 mRNA
Homo sapiens mitochondrial ribosomal protein L4 (MRPL4), TGTGATGCATGTTGTCGCTTTC
MGC16367, L4mt, ACTTAACACACGAGGAGATGCCACAGAGC nuclear gene encoding CCACCCCGGGATCTCCATCTC ILMNJ 658160 MGC2681. CGI-28 ATCGTGGAGGCCACCTCTAGG mitochondrial protein, transcript TCTTCCC variant 2, mRNA
1 785 236 5893 151 15594 270 12262 MRPL4 NM 146387
Homo sapiens endoplasmic reticulum-golgi intermediate
ERGIC32, MGC14345, CTGCGAGTTGGTTGGGCTTGACATTCAG compartment (ERGIC) 1 KIAA1181. ERGIC-32 GATGAGATGGGCAGGCACGAAG (ERGIC1 ), transcript variant 2,
1 781 16486429 92 6268 16473929 ERGIC1 NM 020462 mRNA
Homo sapiens molybdenum GCCAGAAGGCAGAAGGGTAAG
CAATTGGCTCTTTGCGTTTCCAGGTTTTG
MOS, FLJ20733, HMCS cofactor sulfurase (MOCOS), AGAGGGCAAGAGTGAGCAAGA ILMNJ 695087 GGGCCTTGTCACAGATGCCAG
1 765 942 381 2890476 5107393 MOCOS NM 017947 mRNA GATGGAAG
RNF59, OGS1. TRIM18, Homo sapiens midline 1 CAGAGCTGGACGAAGTCTGCT
TTCCCGCTCCCCCATATCAATTTTCCTTTT FXY, OS, XPRF, GBBB1, (Opitz/BBB syndrome) (MIDI), AAGAGAGATGGAGGCTGTGGC ILMNJ 745389
GTCTCCGGGGCTGAGTAAAT OSX, BBBG1, ZNFXY NM 033290 transcript variant 3, mRNA GGACTCCT
1 764 887 8393 18039761 318 30176 MIDI
Fold
Synonyms Description Probe Sequence Probe Id Probβ_Sβquence_l
Change XS No GFs pOS 6 GFs pOS No GFs Common Geπbaπk
Homo sapiens peroxisomal
AACGCACCCTCTCTGTGGAGC
DRS1, KIAA0536, HCA88, D3,D2-enoyl-CoA isomerasθ GATCTGACTAACTTCACTGATATTCCCCC TCTGACTGGTGTAGCTGGAAA ILMN_1678353 dJ1013A10 3, ACBD2 (PECI), transcript variant 1, TGGTGGAGTAGAGGAGAAAGC CAAACAGC
1 762 641 69763 66491016 11720559 PECI NM 006117 mRNA
Homo sapiens zinc finger protein GAAATGAAGTGGACGGCAGCA
CGCTGCTGCGGGCTCGGCGCCGGCCTTT
KOX30 32 (ZNF32), transcript variant 1, ATGAAAAAGCAGCCCTTCTCCC ILMN_1707175 GTCTGCGGGCACGCGCCGCTGC
1 762 91 47681 6533559 11506012 ZNF32 NM 006973 mRNA AGCCCCC
Homo sapiens neurolysin
KIAA1226, AGGTGTGACCTCTCCTTTGCCTGCATACC
(metallopeptidase M3 family) DKFZp564F123, AGTBP TCAAGGCCAGGGGAATATGCC
1 759 9204765 74 235886 13062262 NLN NM 020726 (NLN), mRNA
Homo sapiens ATP-binding
TAPL, KIAA1520, cassette, sub-family B AGCCCAGGATCTGGCTTTGCCAGAGGTT EST122234 (MDR/TAP), member 9 (ABCB9), GCAACATGTTGAGAGAACCCGG transcript variant 2, mRNA
1 753 15371011 92 1268 161 57262 ABCB9 NM 019624
Homo sapiens adducin 3 ACGTCGTACCTGACGCTGAGC
GTGAATGTGCCTGAGGAGTCTCGGAACG
ADDL (gamma) (ADD3), transcript CTGTCATGAGAATGCAACAGG ILMNJ652777 GAGAAACCAGTCCCCGAACCAA
1 751 339 13095 98 785126 172 81429 ADD3 NM 001121 variant 3, mRNA AGCAAACC
GATGCCGACCAGAACCACATG
BBP, DKFZp586E1621, Homo sapiens transmembrane GAACCTTTTCCAAGTTGATCTATCCAGTG AGTCAGAATCATCAGAATATCC ILMNJ 768097 RIS1, p40BBP protein 158 (TMEM158), mRNA ACGTGGCCTGGTGGGCGTTTC
1 747 17185559 5377 7476 9397 739 TMEM158 NM 015444 CACCAAC
Homo sapiens small nuclear GTGAGGCACACATGATTGATG
TGGCCAGTTGCAGGTTAAGCCCCAGAAAA
SMD3 ribonucleoprotein D3 polypeptide GGTATGGGGCCATGAAGACCT ILMN_1705984 GTTCACCTTGGAGAAGCTCCG 18kDa (SNRPD3), mRNA TGAAGAGC
1 738 93 18513 61 500824 10689761 SNRPD3 NM 004175
Homo sapiens COMM domain AGGGACCATGCTGGGCCTCTG
FLJ14987, C20orf92, CAGAGCCCCCACGGATTTCTGCACACTCT containing 7 (COMMD7), CGCCTCTGTACAACCACTGCT ILMN_1815581 MGC33315, dJ1085F17 3 GGGTCTGTGCTGGTGGAACAT
1 737 2546 306 931 2893 1616281 COMMD7 NM 001099339 transcript variant 2, mRNA CCGAACTC Homo sapiens transmembrane AGACCTGACTGCCTGGTTCAG
GTGGAGGAACCTAGCACCTGCCATCCTCT
DKFZP564K1964 protein 98 (TMEM98), transcript CCTCTTCGCTGACCTCGACCC ILMN_1814787 TCCCCAATTTGCCACTTCCAG
1 666 2939226 89589325 14904346 TMEM98 NM 015544 variant 1 , mRNA ACTCTCAA
Homo sapiens brain and
GTACGTTGGTGCCCGCTGCTG reproductive organ-expressed CCTGCCTCTG I 1 1 1 1
BRCC45, BRCC4 TCTAATGCCCTGGAGCCTCCC ILMN_1693060 (TNFRSF1A modulator) (BRE), CAACTCTCACATTTCAGTCCG TGGCCCCC transcript variant 3, mRNA
1 664 7122976 30561844 50885178 BRE NM 199191
Homo sapiens ubiquitm- GGCTCCCAAGGCCATGAAGAA
GGTTTTCAAGGCCTCTGTGGCTTTCTTCT
NICE-5, PRO3094, UBE2Q conjugating enzyme E2Q GATGTACAAGGCGTGCCTCAA ILMNJ 717052 GAACTTACCACCAGCCCTGGC
1 664 19889761 11031012 183 7976 UBE2Q1 NM 017582 (putative) 1 (UBE2Q1), mRNA GTACCCCG Homo sapiens RWD domain GTGCTACAGCAACTGAGACAG
CCAGCCATTCCCAACCCCCTTCTCCCTTA
C21orf6, GL011 containing 2B (RWDD2B), CAACCAAGAGGCAAGAAACCT ILMNJ 732193
NM 016940 CCTGCCTTCACTAAAGAACCC
1 655 12822261 95930954 15900595 RWDD28 mRNA GGGATTGG
Homo sapiens chromosome 10
CCAACGACTAACCCTGAAATGGGGGTGTT
FLJ90798 open reading frame 56 CCAGCCTTCAGCGAGATGGCC
1 646 921 35596 2589268 42662262 C10ORF56 NM 153367 (C10orf56), mRNA
AGATGGATTATCAAGTGTCAAG
Homo sapiens glycogen synthase CCACCCCTAACCTGGCTTATTCCCAACTG
GYS, GSY TCCAATCTATGACATCAATTAT ILMNJ 653395 1 (muscle) (GYS1), mRNA CTCTGCCCACTGTGAAACCAC
1 637 321 78094 14228928 232 70596 GYS1 NM 002103 TATACA
Homo sapiens serum deprivation GTGGGATCGAGACATGTAAGC
GGCCCAGGAAGCAAATCCCCTGCCTTTA
SDR, PS-p68 response (phosphatidylseπne AGCATCATGGAGGTTTGAAGA ILMNJ 725427 GTATGAACCACTATAAGTAACC binding protein) (SDPR), mRNA TGCCGCAT
1 637 121 03928 7367797 12066846 SDPR NM 004657
Fold
Synonyms Description Probe_Sequence Probe Id Probe_Sequence_l
Change XS No GFs pOS β GFs pOS No GFs Common Genbank
Homo sapiens O-6-
CAGCTAGGTGGGGAAAATTCA methylguanine-DNA CAGGTGGGCTGTCTGTAGAGA ILMNJI 721525 GCTGGCCGAAACTGAGTATGTGCAGTAG methyltransferase (MGMT), GATGGATGTTTGAGCGACACAC GAACTGGC
1 627 656 9643 24373096 39708096 MGMT NM 002412 mRNA
Momo sapiens chromosome 14 TGGGGGAGCAAAGCCTGCAAC
GGTGACCTATCCTGGCCCTCTACTCAGAA
MGC24447 open reading frame 147 AAACGGGAGTGGCTGCTCAGG ILMNJ 692113 ACCGGCAATTTGTCTTCACTC
1 626 25876428 11552678 18788512 C14ORF147 NM 138288 (C14orf147), mRNA GGAACATT
Homo sapiens chromosome 3 CACGTTTTCCCATTTGCCCTGT
GCCAGCGGTGATTGCTACTTGAGGTAGTT MGC33365 open reading frame 58 (C3orf58), GGCTCACTGTCTTACAATCACT ILMNJ 742789 TTTTACAACTACCATTTCCCC
1 624 36684344 25221011 41001013 C3ORF58 NM 173552 mRNA GCTGTG
Homo sapiens NADH
GAAAAGCTGTGTCGTGTTCcc
MGC138266, KFYI, dehydrogenase (ubiquinone) 1 , GGCCCTTCAGTGCGATCAAAGTTCTACGT
TGTGAAACTGAGCAGGTGTGT ILMN 1785424 MGC126847, MGC117464 subcomplβx unknown, 1 , 6kDa GCGAGAGCCGCCGAATGCCAA GTTGGCGC
1 618 16835393 717 5601 1160906 NDUFC1 NM 002494 (NDUFC1), mRNA
Homo sapiens chromosome 7 CTCTCTTCCCTGATCCTTGGAG
ACGGGCCTCCGTTTGTGGAGCCGCTGCT
CGI-20 x TAACTTCATCTGGTTCCTGCTG
XM 946T083Jss, χM(Cs i CTsCTGTG rcτGAπcτGGAG ILMN-1700428
1 596 2689226 242 18094 386 88095 C7ORF20 NM 015949
SFM2, DKFZp686F1470, GCTTCCTGGATGAGAAGAGCG
Homo sapiens cullin 4B (CUL4B), GTTAGGAGGAGACTCTTGATGTCACCTTC MRXSC, MRXHF2, GCAGTTTCGTGAGCGACCTCA ILMNJ652280 transcript variant 2, mRNA AGTATCTTGAAAGCGGGTCCC KIAA0695 GCAGTTAC
1 595 53394763 18087262 28853094 CUL4B NM 001079872
Homo sapiens acylphosphatase
CCCCAGAGACGCTCAGCTTGT 1 , erythrocyte (common) type GCTGAAACTCACAGCAAGAGCTGTGTTCC
ACYPE ATCCATTGACTGGAAGTCTGTC ILMNJ 728369 (ACYP1 ), transcript variant 2, AGTTAGCTTTGCTACCAGTTA ACGTGGC mRNA
1 584 16034212 41 121185 65 198235 ACYP1 NM 203488
Homo sapiens mitochondrial
C2orf1, RPL33L, ribosomal protein L33 (MRPL33), CTCCCCAGGAGGATAGTGCAG
GCGAAGCTGGGACAGGTTTCTGCTTCAA MGC23922, MGC111093, nuclear gene encoding AGGACACATCAGGGGCAGAAA ILMNJ 675053 CACCAAGAGAAACCGACTGCGG MGC13694 mitochondrial protein, transcript TGACATCG variant 1 , mRNA
1 573 19746143 1966 106 3091 0227 MRPL33 NM 004891
GGGCCTCCCTTGACCCCAGTA
DKFZp781P1796, Homo sapiens lipin 1 (LPIN1), ACCCAGTGATGCTGAGGTCATGTGCTGG CGAAGTCTATGCCCTGAATCC ILMNJ697554 KIAA0188 mRNA AATGCTGTATTTGGACCACACA
1 566 1141 8392 543 11426 85020593 LPIN1 NM 145693 CCAGAGTA
G6PT3, GSDIb, TRG19, Homo sapiens solute earner
GCATTAGCCTGCATGTTTCTAG PRO0685, G6PT2, family 37 (glucose-6-phosphate GACTGCTGTTGCCAATACCTCAGACTCCA GTCTTCTGCCAAGTGCTTTTCT ILMNJ 805645 GSDId, GSDIc, transporter), member 4 GGGAAAGAGAGGAGGCCATCA CAGTTG
1 559 171 43927 226 30594 35300177 SLC37A4 MGC15729, G6PT1 NM 001467 (SLC37A4), mRNA Homo sapiens NIMA (never in GACAGTTCAGAGGCAGGGACA
GGGCGGCTGCTGTTTCCACACGTGGACT
SID6-1512 mitosis gene a)-related kinase 6 ACAGATGGGGGTGGCCAAGTG ILMNJ 763365 CGGATCTGCTGTGACACCGTCA
1 554 22864761 13957262 21663095 NEK6 NM 014397 (NEK6), mRNA ACAATCGA
GTACAAGGCTTCAAAGTACCT
Homo sapiens THO complex 4 TGGACATGTCTCTGGACGACATCATTAAA
ALY, BEF GTGTGTGTCCCTCATGGAGCC ILMNJ 726415 (THOC4), mRNA CTGAACCGGAGCCAGCGAGGC
1 536 63555597 8484768 1302 7935 THOC4 NM 005782 ACCTGCAG
Homo sapiens BCL6 co-
FLJ11362, AGAGAGGAGCTTGGGTTGCTTCCCTGTC repressor-hke 1 (BC0RL1), B930011H20Rlk CCCGCCCCCTCTGTGGCATTGT
1 535 71 35026 41 92161 6435622 BCORL1 NM 021946 mRNA
Fold
Synonyms Gβnban(( Description Probβ Sβquβπcβ Probe Id Probe_Sequence_l
Change XS No GFs pOS β GFs pOS No GFs Common
Homo sapiens tRNA splicing βndonuclease 34 homolog (S TGCAGTGAACTCCAGAGACCTAGGGGAT
LENG5, SEN34, SEN34L cerevisiae) (TSEN34), transcript GTGGCTGTGTCGGCAGCAAGAG
1 534 17902726 9930226 15237393 TSEN34 NM 001077446 variant 2, mRNA
Homo sapiens deleted in
XTP6, MGC22430, DLB 1, GAGACAGAAGATTGAAGCCTTTGCCAGCC lymphocytic leukemia, 1 (DLEU1 ) LEUI1 BCMS ATTCTTTCCC I I I I I GCTTCC
1 534 20958096 4434018 679 96014 DLEU1 NR_002605 on chromosome 13
Homo sapiens RWD domain GTGGGGACCCTCTTCCTCTAG
CCTGTATAGCTCCAGTCCTGTTCATGTTC
CGI-24, PTD013 containing 1 (RWDD1), transcript CACAGTAAAGCTGGCCTCCAG ILMN_1790574 TCTCTCACCAGCAGTACATCT
1 53 35640625 54 819443 83864365 RWDD1 NM 016104 variant 2, mRNA AAACACGG
Homo sapiens chromosome 1 CTATGTTGACGCTAGCCTGCA
STRF2, FLJ12666, RP11- CGGAAAGTCAACCTCACTCCTCAGCACTC open reading frame 108 CAGACACTTGGGTCTATGAGA ILMN_1680225 781D11 2 ACAGCACCTAGCTCTCCAGGT
1 521 431 44345 314 5476 478 35596 C1ORF108 NM 024595 (C1orf108), mRNA GCACAGTG
Homo sapiens solute carrier family 25 (mitochondrial carrier,
MGC2615, MCSC2, phosphate earner), member 23 TCCTTCGACCTCCACTGCGCCCCACCTCC SCaMC-3, APC2 (SLC25A23), nuclear gene CTGCCTGTGTGTGTTATTTCA encoding mitochondrial protein,
1 515 1127 0059 26744763 405 18094 SLC25A23 NM 024103 mRNA
Homo sapiens ribosomal protein TTGAGAACTGCTGGACCAGAG
ATGGGCAGTATCCGCCGCCATCCTCTTCC
L8 (RPL8), transcript variant 2, CCTTTAGAGCTCTGATAAGGTG ILMNJ719089 GTGAGGCGCGCTGAGACCCGG
1 502 2390726 192 56429 2892351 RPL8 NM 033301 mRNA TCAACAG
Homo sapiens ankyrin repeat and TCCACCCTTCCCCACATCAGTC
ANKS1. KIAA0229, GCCCAGGCCAGCAGAAAGCAGCTCAGAA sterile alpha motif domain GGCCTAATCCAAACCTTGAAAG ILMNJ 737642 MGC42354 GTATTGTTGCTCATGGTGTGGC containing 1A (ANKS1A), mRNA CCTGGC
1 494 244 94345 14684763 21948096 ANKS1A NM 015245
Homo sapiens coiled-coil domain TTTTCCCCTTCGGTCTTCCACA
GGAGGAAGGGACTTTGGAGAATGGAACT
MGC104248, FLJ23031 containing 126 (CCDC126), GCAGTATTATTGTCTTTGTGGA ILMNJ737462 CTTGAGGACTTTAGCCAGGTGT
1 493 59252243 38964825 58206024 CCDC126 NM 138771 mRNA GTTGAC
Homo sapiens zinc finger protein
CTGTACCCAGTGCAGGAAGAGTTTCCACA
KOX30 32 (ZNF32), transcript variant 2, CCAGGGGGAATTGTATTCTGC
1 486 33763928 18628513 276 76428 ZNF32 NM 001005368 mRNA
DJ858B16, Homo sapiens
ATACAGACCTTTGCAGGACCTGATGAGTG DKFZP566G2246, phosphatidylserine ACCCTTCTGGAGCTGGCCAGG
1 485 361 06012 227 42679 337 51013 PISD dJ858B162, PSSC NM 014338 decarboxylase (PISD), mRNA
Homo sapiens piggyBac GGCCAGCGGGGCCGAAAGCG
CCCATGGTCATCCTCCAGAACCTGGCCAA
FLJ90201 transposable element derived 3 GAGTTGGGTTTGCTTA I I M GC ILMN_1680113 AAAGGAAGACCTCAGAAGCGT
1 479 12999345 14702261 21742679 PGBD3 NM 170753 (PGBD3), mRNA TCATTGGA
Homo sapiens LAG1 homolog,
CerS6, MGC 129950, CACAGGTCCATGAAAGTTTGGCTTCCTGG ceramidθ synthase 6 (LASS6), MGC129949 TTTGATGTCTGTTGCGTGGCC
1 476 93478094 72573096 10705768 LASS6 NM 203463 mRNA
Homo sapiens glutaredoxin 2
GGAGGTGCAACTGACACTCATAGGCTTCA
GRX2, bA101E13 1 (GLRX2), transcript variant 1, CAAAGAAGGAAAATTGCTCCC
1 472 55065594 51786426 762 17676 GLRX2 NM 016066 mRNA
TCAGTCACATTCGCTTCAGTCC
Homo sapiens GDP-mannose 4,6 CCTCCAGGGTTTGGGTCGCTTTGCGTTTG
GMD TACGGGCGAGTGGACGGAGG ILMN_1675188 dehydratase (GMDS), mRNA TCGAAGCCTCCTCTGAATGGC
1 47 961 0893 30560596 44905594 GMDS NM 001500 GCTTGCTG
Homo sapiens chromosome 11
CCCCTCAGGAGAGAGAAAACTTAGTGCTT
P5326, BlesO3 open reading frame 68 CCAGCCCTTCTTGGAGCCTTC
1 463 44609344 27933093 4086476 C11ORF68 NM 031450 (C11orf68), mRNA
Fold
Synonyms Description Probe_Sequence Probe Id Probe_Sequence_l
Change XS No GFs pOS β GFs pOS No GFs Common Geπbaπk
Homo sapiens heat shock 6OkDa
HuCHA60, GROEL, protein 1 (chaperoπin) (HSPD1 ),
GAGGGGACACGGGCTCATTGCGGTGTGC HSP60, SPG13, CPN60, nuclear gene encoding GCCCTGCACTCTGTCCCTCACT HSP65 mitochondrial protein, transcript variant 1 , mRNA
1 455 3762336 636984 92 75597 HSPD1 NM 002156
Homo sapiens proteasome
GCTCCGAGGTGACCCAGCACA
PA28bela, REGbeta, (prosome, macropain) activator TGATTTTGGGGTAGCAATCCAGGAGAAG TCACCATCCACTGCCTTAACAT ILMNJ 788377 PA28B subunit 2 (PA28 beta) (PSME2), GTGCTGGAGAGGGTGAATGCCG GACCGTG
1 45 1819406 10786726 15642727 PSME2 NM 002818 mRNA
Homo sapiens MAP kinase interacting serine/threonine ATCGGTGTCTGCTGCTGTGTCCCCAGGT
MNK1 kinase 1 (MKNK1), transcript CTTGTGTGGGTGGCACAGATCT
1 447 312 37262 13227261 191 20178 MKNK1 NM 003684 variant 1 , mRNA
Homo sapiens fibroblast growth
GGATCCGCTCTACTCAGGGGC factor (acidic) intracellular GGCTCCTTGGGAACTGAGACATATCTCAG
FGFIBP, FIBP-1 AACACAAAGCCATTTCCACCTG ILMNJ655449 binding protein (FIBP), transcript GGAATGGTGTCTGTGCTCAGC TGGCTCC variant 1 , mRNA
1 446 346 13928 19768929 28600177 FIBP NM 198897
Homo sapiens interferon induced
TATCTTCCATTCCTCGCCCTGCCCCCAGA
1-8D transmembrane protein 2 (1-8D) GGCCAGGAGCTCTGCCCTTGA (IFITM2), mRNA
1 438 1643969 47062646 6769831 IFITM2 NM 006435
Homo sapiens inhibitor of DNA
GIG8, MGC26389, ID2A, binding 2, dominant negative GCAGACTTTGCC M I I I I ID2H helix-loop-helix protein (ID2), CGTGAATACCAGAAGGATCCA
1 436 4553 106 10984476 1577 1643 ID2 NM 002166 mRNA
Homo sapiens cytochrome b5
CATGTCTTGCCTCAGACCCTCACACACTG
FLJ32499 domain containing 1 (CYB5D1 ), TCCTCTCTGCCTGCAACACTC
1 431 27995178 262 78513 37584344 CYB5D1 NM 144607 mRNA
Homo sapiens sperm CCAGGTCAGAAACCATTGTTCA
CTGTCAAAATCCAAGCTGCCTTCCGGGGA
SP17, SP17-1 autoantigenic protein 17 GAAGACCTCCCTGTGAGAGAG ILMN_1787552 CACATAGCCAGAGAGGAGGCA
1 428 34599762 482 79346 68964343 SPA17 NM 017425 (SPA17), mRNA TTGCTCC
Homo sapiens RAB, member of
RAS oncogene family-like 2A CAAGAAGAGCTTCCTTTAAAGTTCCTATTT
MGC117180
(RABL2A), transcript variant 1 , CAGCATAAAGAGGCTGTCCT
119 32678 58683617 83 13521 RABL2A NM 013412 mRNA
Homo sapiens twist homolog 1
GTCTTCCCAGTTTCTCCAAGCT
TWIST, ACS3, BPES2, (acrocephalosyndactyly 3, AGACGGGCAGCGGCACCATCCTCACACC GCTTCTGGAATGCAGGTCTGT ILMNJ 778964 SCS, BPES3 Saethre-Chotzen syndrome) TCTGCATTCTGATAGAAGTCTG CGGCTGG (Drosophila) (TWIST1), mRNA
1 414 1101 1726 42647678 60331006 TWIST1 NM 000474
Homo sapiens calmodulin 3 TTCCACCCCAAGAGAACTCGC
CAGCCAAGAGCTGAGGGTAAGGGCAGGT
PHKD, PHKD3 (phosphorylase kinase, delta) GCTCAGTAAACGGGAACATGC ILMNJ 699704 AGGCGTGAGGCTGTGGACATTT
1 401 5736756 6732 0645 9429206 CALM3 NM 005184 (CALM3), mRNA CCCCTGCA Homo sapiens excision repair cross-comptementing rodent repair deficiency,
CCCGGAGGCTGTTTGATGTCCTGCACGA
UV20, C0FS4 complementation group 1 GCCCTTCTTGAAAGTACCCTGA (includes overlapping antisense sequence) (ERCC1), transcript
1447 0894 16860977 23606143 ERCC1 NM 001983 variant 2, mRNA
Fold
Synonyms Description Probβ_Sequβπcβ Probe Id Probe_Sequencβ_l Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
Homo sapiens ribosomal protein CGTAAAATGGGGGTCCCTTACTGCATTAT SURF3, TRUP
1 398 96507263 76661426 1071 9518 RPL7A NM_000972 L7a (RPL7A), mRNA CAAGGGAAAGGCAAGACTGGG Homo sapiens chromosome 22 CTGCGGGCTGCGCGAGTCCC
CACCACTCAGAGTGACCTGTCCCTGTGTG
MGC70831. N27C7-4 open reading frame 16 GGGGCGGCGAGTCCCGGCGC ILMNJ689380 AGGGCTTCAGCGAGGCCCTGA
1 396 10455977 645 78094 90229346 C22ORF16 NM_213720 (C22orf16), mRNA TGTCCGCGTC
CCCCATGTGCTGCTGAGTGGC
Homo sapiens tetraspamπ 5 GGCTGTGTGCCCCAGTTTGAGAAGTGGT
TSPAN-5, TM4SF9, NET-4 I CAAGATGATGCCAGGCTGCCC ILMN_1769787 (TSPAN5), mRNA TGCAGGACAATTTAACCATCGT
1 393 5196893 869 1726 12107643 TSPAN5 NMJD05723 TATACACT
Homo sapiens crystallin, zeta
DKFZp779E0834, CATTATTGGTTGGCTGCCAATGACCCCAT
(quinone reductase) (CRYZ), FU41475 ATGTTCTGTGAGAATAGTAGC
1 388 50072263 575 5559 7986643 CRYZ NM_001889 mRNA
Homo sapiens NADH
AGCAGGCACCCAGGCTTTAGA dehydrogenase (ubiquinone) 1 GAGACAAAGATGGCTGCGAGAGTCGGCG
B9 GAAGTATAGGGGGCTTCTTCC ILMN_1712755 alpha subcomplθx, 3, 9kDa CCTTCCTCAAGAATGCCTGGGA CTGCTGGG
1 386 3457831 1690856 2343 1643 NDUFA3 NM_004542 (NDUFA3), mRNA
PREDICTED Homo sapiens abl TGGTTGGTATGAGGGAGTTATGAATGGAG interactor 2 (ABI2), mRNA TGACTGGGC I I I I I CCTGGGA
634 7976 5996643 8304393 AB I2 XM_001126750
Homo sapiens stress-associated bA269C23 1 , RP11- endoplasmic reticulum protein TGCTTTTCTGTTGGCAGGATTAGTAGCCA 269C23 1, C13orf21, family member 2 (SERP2), CGCGGGTCGTCCGCAGCAGTG MGC35505
1 383 26062677 184 72678 255 5476 SERP2 NM_001010897 mRNA
GTTCTGCGCGGCGGGGGCCG
LPTS, MGC8850, Homo sapiens PIN2-ιπteractιπg TTCCAAATGAATCCTTCCCAGCCGGGGCC TACCCGCGGCGGAGCGAGGA ILMNJ 707099 FLJ20565, LPTL protein 1 (PINX1), mRNA TTCCGACCACTCAGCTGTCAG
1 383 72 31564 97 305954 134 5476 PINX1 NM_017884 GGCGAGAATG
Homo sapiens layilin (LAYN), ACGACCTCCTGTTGGACCCCCACGTTTTG
FU30977, FLJ31092 1 382 9593726 373 15594 515 76013 LAYN NM_178834 mRNA GCTGTATCCTTTATCCCAGCC
CATATAAGCCCTGGGTCGGGG
Homo sapiens KIAA0240 AGGGAGGCCTTACAGACTGACTTTACTTA
DKFZp686P0250 GGTAACTGTGGGGATCACTGC ILMN_1688372 (KIAA0240), mRNA AAGAGGACGCGTCACTCGCTG
072 23226012 22022263 15864346 KIAA0240 NM_015349 CTGAGACA
TUBB-5, MGC132410, Homo sapiens tubulin, beta 6 AGGCTACGTGGGAGACTCGGCGCTGCAG 0718 1687981 2604806 1871 0809 TUBB6 HsT1601, MGC4083 NM_032525 (TUBB6), mRNA CTGGAGAGAATCAACGTCTACT Homo sapiens MyoD family CCTAAGCCCCAGTTGCACCTA
CAGACTCTGAATGCCGACTGTGTGGACTC
HIC inhibitor domain containing CTAACTGCAGTCCCTTTTGCTG ILMN_1684755 TCTTCCTCAGACTGTGGGGAC
0714 1678393 233 16428 1664226 MDFIC NM_199072 (MDFIC), mRNA TCTGCCG
KIAA0337, P164RHOGEF, Homo sapiens Rho guanine
TCCCACTTGAGAGCAGCCTCTACCTGACC p164-RhoGEF, FLJ90019, nucleotide exchange factor (GEF) CCCTGGACCACAGAGAGCCAC TEM4 17 (ARHGEFI 7), mRNA
0711 4544226 264 28928 187 93095 ARHGEF17 NM_014786
Homo sapiens methyl-CpG
GTGATGATGCGACTGAGGATTATGCAACG
KIAA1887 binding domain protein 6 (MBD6), TGGTCCAACCGGAGCGGCCAG 0711 381 03094 274 98096 19540594 MBD6 NM_052897 mRNA
Homo sapiens interleukin 15
GCCCTGAGGGCTGAGTTCTGCACCCAGT
MGC9721. IL-15 (IL15), transcript variant 1, CAAGCTCAGGAAGGCCAAGAAA 0711 4842914 69291595 49202026 IL15 NM 172174 mRNA
MINI, MIN2, PROTECTIN,
Homo sapiens CD59 molecule, MIN3, 16 3A5, MSK21, GGCAGGAGAAGGGGTGTTCAT complement regulatory protein CCTCATAGGGACTTTGCCTCCTGACAGCA MGC2354, EJ16, EL32, AGAAGCAGTGTGCAGGTGAGG ILMNJ 655245 (CD59), transcript variant 2, GTTTATGGGTGTTCATTGTGG EJ30, p18-20, G344, CAAAGTGC mRNA MIC11
361 91846 5067851 35882263 CD59 NM 000611
Fold
Synonyms Description Probθ Sβquβnce Probejd Probe_SequenceJ
Change XS No GFs pOS β GFs pOS No GFs Common Genbank
HSEC10, DKFZp666H126,
Homo sapiens exocyst complex CACACTCGCCCATTTTCTAAGTGGTTTAG PRO1912, SEC10P, component 5 (EXOC5), mRNA AAGGTTGCAGTCTGCCTCACC SEC10L1, SEC10
0706 80835495 79464554 56081486 EXOC5 NM_006544
MAGE-D2, MGC8386, Homo sapiens melanoma antigen CATGGACTCCTGCCGACTCTG
ATCCAGGCGGGAGCAGAAGCTAAAGCCA MAGED, JCL-1. BCG1, family D, 2 (MAGED2), transcript GTAGCTGGGACGCTGGTTTAT ILMN_1668242
AAGCCCAAGAGAGTGGCAGTGC 11B6, HCA10 variant 3, mRNA GGCATCCT
0705 352 18512 193 18512 136 1101 MAGED2 NM_201222
DRDL5813, KIAA1980, Homo sapiens tetratricopeptide CCGCTGAAGCTGTAGGAAGCG
ATAGAAGGTGGGAACCAGGTTCTGTGAG DKFZp313M1015, repeat domain 14 (TTC14), CCATTCTTCCCTGTATCTAACT ILMNJ 767470
GCATTCTACCTCACCAGCAAGC FLJ00166, PRO19630 transcript variant 2, mRNA GGGGCTG
0703 25643512 30009344 211 14761 TTC14 NM_001042601
Homo sapiens BMH polycomb
MGC12685, PCGF4, BMM, ring finger oncogene (BMH), TGGTCGAACTTGGTGTGTGTTCATCACCC RNF51 ATCAGTTATTTGTGAGGGTGT
0702 706 9226 8906101 6246809 BMH NM_005180 mRNA
Homo sapiens RB1 -inducible GCTAGAGGCCAGGA I I I I GAG
CAGTGGATTGGTCATCTGGGTTCTAAAGG
DRAGOU14, FIP200, CC1 coiled-coil 1 (RB1CC1), transcript ACCAGCTTCGGCAATACGGTG ILMNJ657701
NM_001083617 GAAGAGTCTGTGCTACTAACC
07 800 99347 557 4976 390 1476 RB1CC1 variant 2, mRNA AGACCTTG
Homo sapiens synovial sarcoma
MGC78386, MGC26711, translocation gene on CTGATΠTGTCAGGGTTTTTCTACGTGTA
LP2261. KIAA0693, chromosome 18-lιke 1 (SS18L1), GGCGTGAATAGGGGGCACCCC
CREST
0698 9977262 137 08928 95714294 SS18L1 NM_198935 mRNA
Homo sapiens interferon AGGGGCTTTTGTATTTCCTGCC
CTTTGGGTGGCCTTTGTGGACGGCTCGT
MGC72189 2 T (&IRFZ2ϊSBPX2),* t Orarnscript variant T 1, TCTGCCCCACCCCCAAACCTC ILMN 1667761
U „I o„IA._IA. AGCTGGAAAGTGTTGATCTGGG
0698 17966013 19990178 13959763 IRF2BP2 NM_182972 mRNA
Homo sapiens squaleπe GTCAGAACCTTGGATTACAAAACCTCGAG
FLJ30795
0697 11287893 113006 78698926 SQLE NM_003129 epoxidase (SQLE), mRNA CCCTTCTCAGTAGTGGTGCTG
TGATGGCTCCAGAGAACACAC
SLRR1A, PG-S1. PGI, Homo sapiens biglycan (BGN), TCCAGCGCAAGGAGGGGCTGCTTCTGAG CAGCTATTTATGAGCCTCTGCC ILMNJI 713029 DSPG1 mRNA GTCGGTGGCTGTCTTTCCATTA
0696 31918273 22501 648 15651 064 BGN NM_001711 CCCAGGC
Homo sapiens protein kinase,
MGC57364, AMPK, AMP-activated, alpha 1 catalytic TGATTTCTCACTGAGAGGAACTTTTCTAC MGC33776, AMPKaI subuπit (PRKAA1), transcript CAGGTTGGGGCATATGGGAGC
0694 43081427 690 15173 47922678 PRKAA1 NM_206907 variant 2, mRNA
HST17250, PRKM6, Homo sapiens mitogen-activated
TGCCTACCTAGCTGCATCTATAATGTCAG P97MAPK, ERK3, protein kinase 6 (MAPK6), CTTATCCTAAGGCTGTCCACG
0694 10880143 1430856 992 30176 MAPK6 DKFZp686F03189 NMJD02748 mRNA
ATGTACGTGGGGGATTCTTGA
MGC33897, KIAA0033, Homo sapiens transmembrane CACAAGAAGACAAGCATCTGTGGTGCGG CTCGGGTTAGTCTCTGGGGAT ILMNJ 706644 MGC57262 protein 41 B (TMEM41B), mRNA AGGCAAGCAGGCTAACTAGGAG
0693 4958851 671 3143 46543927 TMEM41B NM_015012 GCAGAGCC
Homo sapiens dual-specificity
GGAGCTGAAGGTCGCCATGAA
HP86, DYRK, DYRK1, tyrosιne-(Y)-phosphorylatιon GCAGAACACCGCGTTTCATTCTATTGGTC GAAGACCTTCTTCAGTAAACTC ILMNJ 787434 MNBH1 MNB regulated kinase 1A (DYRK1 A), AATTCCATGTGGCTGACTAGG TACCCAG transcript variant 4, mRNA
0693 36968094 457 56012 317 1518 DYRK1A NM_130437
AT2R1A, AT2R1B, AT2R1, Homo sapiens angiotensin Il GTACAATGTTATCTCTGTGGGA
CAACAGGAGATGAGAGTTCCAGATTGTTC AT1. AT1B, AGTR1B, receptor, type 1 (AGTR1), GGAAGGAGGCAGGCTGTGGT ILMNJ 803110 TGTCCAGTTTCCAAAGGGCAG AGTR1A. AG2S, HAT1R transcript variant 1 , mRNA GGGACTGG
0692 532 006 20464977 14157893 AGTR1 NM 000685
Fold
Synonyms Description Probe_Sequence Probejd Probe_Sequβnce_l
Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
Homo sapiens dual-specificity
OYRK5, hYAK3-2, RED, tyrosιπe-(Y)-phosphorylatιon GCAGTGTATTGCCAAAACTGATTAGCTAG REDK regulated kinase 3 (DYRK3), TGGACAGAGATATGCCCAGAG
0681 10886432 16652261 11351428 DYRK3 NM_003582 transcript variant 1 , mRNA MTW1, hMιs12,
Homo sapiens MIS12, MIND AGAAGGCCATGACTCTTTAGG MGC2488, GGAAAGGGGAGAAATAGCAATGGTTGTTC kinetochore complex component, TGTGTATGTGTACCTTTCAGCA ILMN_1775192 2510025F08Rlk, CTAAGGTATTGCTTGCCCTCC homolog (yeast) (MIS12), mRNA TCCTAGG
0681 2750476 64605597 43969763 MIS12 KNTC2AP NM_024039
Homo sapiens family with
MGC21688, PRO1378, GGGCCTTGTAGGCTTTGGCAGGTAAGAG sequence similarity 131, member FLAT715, C3orf40 GGCCCAAGGTAAGAACGAGAGC A (FAM131A), mRNA
0677 11685179 13783511 9323512 FAM131A NM 144635
Homo sapiens ER degradation CGCCTGGCAACCAAGTATCAT
GGGGGGTAGAATTTAGTAAATATTCCAGC
C1orf22 enhancer, mannosidase alpha- ACCGTTCCACTGCCACCAAAA ILMNJ766851 CGGTCGTTTTATGCACAAGGC
0677 33074347 54032263 36609763 EDEM3 NM 025191 like 3 (EDEM3), mRNA GGAAGGGT Homo sapiens low density CTCAAAGAAGTTACACAGCCTT lipoprotein receptor (familial GCACGAACTGGACTGTGTGCAACGCTTTT
FHC, FH GGCTGAAGCAAACTGCCTAAA 1689371 hypercholesterolemia) (LDLR), TGGGAGAATGATGTCCCCGTT
AGGAGCC
0675 1709 3934 1200206 81078094 LDLR NM 000527 mRNA
Homo sapiens phosphonbosyl pyrophosphate synthetase- AGGGAAGCTGAGCGCCTGTGGCCCTATT
PAP39 associated protein 1 (PRPSAP1), ACTATCCAGTTGGCCTCTCCCA
0673 1285606 1537 5642 1034 3893 PRPSAP1 NM 002766 mRNA
Homo sapiens mesoderm
GGTTGTGTTATCACTCCCACCCCCTACCC
MGC99595 development candidate 1 CAGCCCGTCTTCCGGAATTTC
0672 2504816 12697262 85306 MESDC1 NM_022566 (MESDC1), mRNA Homo sapiens T-box 3 (ulnar TTATTCTCAATACCTGACAGGG
CACCAAAATTGGGGAAGGAGTGCCACTTT
UMS, XHL, TBX3-ISO mammary syndrome) (TBX3), GCCCATGGGAATGACTTCAGA ILMNJ 813544 CCAGCTCCACTTCAAATTCCT
067 4629643 56973926 381 9101 TBX3 NM 005996 transcript variant 1 , mRNA AGCATCC Homo sapiens SH3-domaιn kinase binding protein 1 CTTTTGCTTCAGGCTAAGAGCTGCCTCGC
GIG10, MIG18, CIN85 (SH3KBP1), transcript variant 1, TCTTTGTCCCCCCATTAGGAT
0663 18798977 3121 9644 20674644 SH3KBP1 NM 031892 mRNA
Homo sapiens putative GGTGAGAGGAAATGTTGACTG
DKFZP564F013, GAAACACTGGGCTGTTTGCACAGCTCCAA homeodomain transcription factor GCCAAAAATATCTTTTTTCCCC ILMNJ712159 FLJ33324, MGC86999 CTGTGCATGCTCAAAATGTGC
0662 47 288147 7898961 52 356567 PHTF2 NM 020432 2 (PHTF2), mRNA CACTGCG
Homo sapiens transmembrane AGGACATCCACAGGGTAGAGGTTGGGTG
FLJ23375 protein 62 (TMEM62), mRNA TGTGTACGGGAGTGTCTGAGGC
066 200 37262 350 5268 231 18927 TMEM62 NM 024956
CCACCATGCCCAGCCTGAATG
Homo sapiens LEM domain TACCTGAAACTGTTAAGCCGACCAAGATC ATGAATTTATGTGAACACAAAG ILMNJ 702244 containing 3 (LEMD3), mRNA CCTCCCTGCAAGACAGATGGG
0659 385 1726 620 3059 40806427 LEMD3 NM_014319 CCCTCTG
Homo sapiens epithelial
GAGGGCAAGCCACCAAATTACCTAGGCT
CL-20, EMP-1. TMP membrane protein 1 (EMP1 ), GAGGTTAGAGAGATTGGCCAGC
0658 5699873 9450889 6218006 EMP1 NM_001423 mRNA FLJ31484, MGC120170, HFL-EDDG1, Homo sapiens slowmo homolog 1 GAGTACAGGAGTCTGGAGTCCGTTGAAG
DKFZp547K106, C18orf43, (Drosophila) (SLMO1), mRNA GGTAAAGGCCTCCCGCAAGCTG
0658 157 17679 179 18512 117780945 SLMO1 PRELID3A NM_006553
Synonyms Description Probe Sequeπcθ Probe Id Probe_Sequeπce_l
Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
Homo sapiens proteasome
AGTTCCACAGGCTCCCGTCCA
MGC14274, S2, TRAP2, (prosomβ, macropain) 26S CAGTGTTGTTGGCCCACGGGGAACGGGC GGGGGAGGACTACGGCAAAG ILMNJ668408 P97 subunit, non-ATPase, 2 AGAATTGGCCACTGAGGAGTTT GTGTCATCT
0652 1600 131 4684081 3053081 PSMD2 NM_002808 (PSMD2), mRNA
PIG9, RAFTLIN,
CTTGTGTTGCAAGGGCAACCT KIAA0084, MGC141678, Homo sapiens raftlin, lipid raft CTGGCGAACCTTGGAGAGGGAATGCTGA CGTCCATTTTAACTGGCACCTC ILMN_1702973 PIB10, MGC44480, MIG2, linker 1 (RFTN1), mRNA TTGTCTTGACCAAACCCACAGC AGGGATT FU23866
0639 2722081 29933228 1912 1226 RFTN1 NM_015150
Homo sapiens s.gnal transducing TGCAAGTGCCGCTGTTCGACC
STAM2B, DKFZp564C047, GCATTTAGTCAGTCCCCCAAACAGTCATG STAM2A, Hbp :rrr2(«sτ3AM2rιπ CCAACTGTGAAGGAATGTCCC
A ^CAGCC™CT *™»«*><χ w™
0637 14006429 23546844 14993512 STAM2 NM_005843 mRNA
Homo sapiens synovial apoptosis CCCAGTGACGTGGAAGTCATC
KIAA1810, MGC40372, GCCAGACTCCTGGTCTTTCCAGTTTAGAA inhibitor 1, synovιolιn (SYVNI), AGAACCCCACGGTACTTGGAG ILMNJ656165 HRD1 AAGGCTCTGTGCCAAGGAGGG transcript variant 1 , mRNA TACCTCTC
0636 5959226 682 90594 43420593 SYVN1 NM_032431
Homo sapiens vacuolar protein sorting 16 homolog (S TGTGTCAGGACCTGCGTGTGCTCAATGCT hVPS16 cerevisiae) (VPS16), transcript GTTCGGGACTATCACATCGGG
0635 4766449 44664005 28 369137 VPS16 NMJ322575 variant 1 , mRNA
Homo sapiens CAMP responsive GAAGCGAAATCGGGCTTCCAC
LZIP, LUMAN, MGC19782, ACTCAGGCTAGATATGAGGATATGTGGG element binding protein 3 GGCAGCATCTTCAGCTCTTGG ILMNJ653515 MGC 15333 GGGTCTCAGCAGGAGCCTGGGG
063 67 84902 113868454 71 69055 CREB3 NM_006368 (CREB3), mRNA GTTTAGCA
KIAA1020, ZBTB30, Homo sapiens hypermethylated CTCCTGTACTGGCCACCGCCGCTGTCAC HRG22 in cancer 2 (HIC2), mRNA TTGTCACATTGAGTTCATGTCC
0629 55 752842 9986012 62 83265 HIC2 NM_015094
Homo sapiens SH3 and PX CTTGCTTCAGTTGAGACCTACG
CCCTTGGCCTGCCACTTTCCAGGTGTCCT
SH3MD1. FISH domains 2A (SH3PXD2A), TTTTGGCCAGTCCCAGCAGGA ILMNJ 685810 TTATCACTTTGACGGGACTCT
0628 3682 1392 3171 6309 19945142 SH3PXD2A NMJ314631 mRNA AGATATC
Homo sapiens hepatoma-deπved AGGCAAACACAACTCTTGACTG
TAAAGCTGGAATCAGCAACAGCCCTATGG
HDGF2, CGI-142 growth factor, related protein 3 CCCTCCCACCCTCCTACCTGTT ILMNJ 764617 GAAACCAGACAAAGCATTGAC
0627 327 18512 752 1476 472 37262 HDGFRP3 NM_016073 (HDGFRP3), mRNA CAGTAC Homo sapiens purine-rich GACCACAAAGTTGAAGAATTCA
PURALPHA, PUR-ALPHA, CGTGCAGCAATTTCCAGTGAACCTGTACT element binding protein A TCAAGTCTATATTTTATTCTGTT ILMNJ 669745 PUR1 TGGACATCAGGTAGTGAGTCT
0626 4589893 5957726 373 19763 PURA NM_005859 (PURA), mRNA CTTAT
DIPLA1, IGFBP-4asβ, Homo sapiens pregnancy- GGCTGCCAGACAACCAGCCCC
CACAATTCCAATCC 1 1 I I I ASBABP2, PAPPA1, associated plasma protein A, CGCCATACATTCTGCACCAACA ILMNJ 810805 GCGCATAAATTTGCTGCTCC
0624 52178145 57500183 35909763 PAPPA PAPA, PAPP-A NM_002581 pappalysin 1 (PAPPA), mRNA ATTAAGC Homo sapiens opsin 3 (OPN3), CACCTTCCTGGTCTGTTGGATGCCTTATA
ECPN
0623 517 7101 161 73096 100 88095 OPN3 NM_014322 mRNA TCGTGATCTGCTTCTTGGTGG
Homo sapiens ATPase family, ATGACACTCCTGTGCTTTCTGG
AFDC1. FNP001, CCAGAATTCTGTTATAGGCACCTAACCAC AAA domain containing 1 GGCTTCTGGCCTCCTATGCAG ILMNJ 706649 FLJ14600 GCAGCATGAGGAAAACGGCAC
0623 21858928 27649762 172 20595 ATAD1 NM_032810 (ATAD1), mRNA TCATTCT Homo sapiens tetratπcopeptide GAGGCAGCATCCCGCGGCGC
FLJ33201. FLJ12788, GCTGCCCTGTGGGTCTTGCTCAATACTGT repeat domain 31 (TTC31 ), TGACGGTCCTGGGGAGAGCAT ILMNJ 701937 MGC 120200 TCATACCTGGAGAGAGAAGGT
0622 3706518 554 381 34540594 TTC31 NM_022492 mRNA GGCGCCGAG
Homo sapiens zinc finger protein GCTCCTGTGTTACAAGGGAGAACTCATTT
ZABC1
0619 417 33093 39978094 247 31429 ZNF217 NM_006526 217 (ZNF217), mRNA GAGATCAGTCTGTTGGCATTG Homo sapiens AGAGTCCTGGGGAGCTTCTGT
GGTCTTACAGCCTTCCAAAATAACTCCAG
MSTP006, FLJ10983 phosphoglucomutase 2 (PGM2), CCACCTGTCCTGCAGAGGAGT ILMNJ661589 TTGGGCACCCATGAGCTAGGA
0615 17926428 5086643 31266013 PGM2 NM 018290 mRNA CGTTTCCA
Fold
Synonyms Description Probe_Sequence Probe Id Probe_Sequence_l Change XS No GFs pOS β GFs pOS No GFs Common Gβnbank
Homo sapiens protein-L-
TCCTGATCTCACTGTACACTCC isoaspartate (D-aspartate) O- TCTAGCATCAGATCAATCCCAAGAATCCA
FLJ10883 CTTTCCTGGTCTGCTAAGTAGC ILMN_1726678 methyltransferase domain GGGTGT TCAGCAACCTCAGACCAACCC containing 1 (PCMTD1), mRNA
0614 3581476 10591428 650433 PCMTD1 NM 052937
Homo sapiens FCH and double
AGTGCACAGGTCAGGGCTCGGAGGGAGC
NWK, KIAA0769, SH3MD3 SH3 domains 2 (FCHSD2), CTCTGTGCAGATGTGCTTTCTT
0613 22827261 159 38095 97 768456 FCHSD2 NM 014824 mRNA
Homo sapiens EH domain ACCACTGAGACCCCAAACCAC
GCCAGAAACAAGCCCTGTGGTTTGAAGGT
KIAA0903, NACSIN binding protein 1 (EHBP1), CTATCCCCAGTAGATGGCCCT ILMNJ732750 GAGCTGTGAGGATGGGACTAA
0613 17150059 1300 5642 797 33093 EHBP1 NM 015252 mRNA GCCAAGAC
Homo sapiens laminin, gamma 1 GTGTCATCCTCACTCGGGACG
TATGTGCCTTCACTTTAGCTGTTTGCCTTA
LAMB2, MGC87297 (formerly LAMB2) (LAMC1), CAGGGACCGTTTTTAAATCACA ILMN_1732439 CTCTACAGCCTTGCTCTCCG
0609 10410956 9080456 55260977 LAMC1 NM 002293 mRNA GGGGCGT
Homo sapiens calmodulin
MGC 150680, KIAA1078, CTGAGGGGCTGCTCTATGCTG regulated spectrin-associated GGTTTCATGGACACTGTTGAGCAATGTAC RP11-93N17 1, TGTATGCGCCTCTCTGGCATC ILMN_1754842 protein 1-lιke 1 (CAMSAP1L1), AGTGTATGGTGTGCTTACCTG MGC150681 CGAGACAT
0607 3872268 5957018 361 56427 CAMSAP1L1 NM 203459 mRNA
Homo sapiens olfactory receptor, GCGGAAGAGGAAGAGCCACC
GGCCATTGGCTTTGGCATCTCCCTGGCG
OR7-9, OR7-3 family 6, subfamily B, member 1 GCCTGTTAAAATAGCCTGGAAA ILMNJ 666715 AAGATCTACTTCATCTCCTGCC
0605 79272835 77 33156 46 74492 OR6B1 NM 001005281 (OR6B1), mRNA ACTGCGGC
ATGAAGTACCGAGAGGCTAAA
ALK2, SKR1, FOP, ACTRI, Homo sapiens activin A receptor, TTCAGTTCATATGCAGAACGTATTTAGCC CCCACTGGCCTAAGATCTCAC ILMNJ716790 ACVRLK2 type l (ACVRI), mRNA ATTACCCACGTGACACCACCG
0605 12082643 1511 2227 913 36426 ACVR1 NM 001105 CAAAGTTC
MECA39, ECA39, PNAS- Homo sapiens branched chain
GGAGCTGGGGCTCAACCCACTGTTTTTAA
121, DKFZp686E12175, aminotransferase 1 , cytosolic GGATTTGCGCTTACTTGTGGC
BCT1 (BCAT1), mRNA
0.605 11145809 14047976 84909766 BCAT1 NM 005504
Homo sapiens chromosome 10 CCTCGAGGACTCTCTGCGTCT
GAGGCTCTCCATGGAAGGATGAACACATA
FU13490 open reading frame 88 CTGGAGACAAGGGCACTACAC ILMNJ676689 TGAGTCAAGGGATTGCAATTC
0604 7723142 211 53513 12791428 C10ORF88 NM 024942 (C10orf88), mRNA GCACTTCA
Homo sapiens ubiquitin specific CCTACACTTTGCCTAATTGAGCCACTACC
KIAA1594, MGC117261 peptidase 37 (USP37), mRNA AGGTTTTCTGGCAGCTGTGGC
0602 54445297 118 55178 71 39479 USP37 NM 020935
Homo sapiens golgi GCTCTGAGACGAATGCTATGG
AAACTAATGAGTGTTTGCGTGTGGTGTTT
P138, GIMPC, GPP130 phosphoprotein 4 (GOLPH4), GCTGCAGATGACTTCTTAGAG ILMNJ 760062 CTATGCGAGCACCCATTCTCA
0602 52780597 9403143 56534766 GOLPH4 NM 014498 mRNA GATTTGCC
CCCTGCTGGTGGCTCTGTCCT
SMAP, Smg-GDS, KAP3, Homo sapiens kinesin-associated GTTGTTAGCTGCAGATTAACCCCAGCCCC CTGTTAGGCACCACACTGGTT ILMNJ 764431 -J190I16 1, FLJ22818 protein 3 (KIFAP3), mRNA TCTGTCTTCTGTTAAGTACAG
0596 44755597 575 3601 34301428 KIFAP3 NM 014970 GGTCAACT
FLJ90266,
DKFZp686O24210, LL5A, Homo sapiens pleckstrin TGTAGGGCGGGGTGGTGGGC
ACTAAGCCCACCTCCCCTGCTCTCCTTCC
DKFZp686H039, homology-like domain, family B, CAAAGTTAGGACACTGCGTAAA ILMNJ 723168 CAGCATTGAGCCCTTGGTTGC
FLJ00141, KIAA0638, member 1 (PHLDB1), mRNA ACAGGCCA
0594 6588059 5546018 32939343 PHLDB1 MGC111531 NMJH 5157
TNRC14, SMRT, TRAC1, Homo sapiens nuclear receptor GATGGGGTACTGCCGGTCTGT
CTGCTGCTGTGCTTTTGATCTCTGCTTAC SMRTE, TRAC-1, SMRTE- co-repressor 2 (NCOR2), GTTGTCTTAGAAGTAGATGTGT 652754
CGTTCAAGAGGCGTGTGCAGG transcript variant 1 , mRNA GATGGCC
0593 45235894 5314 9727 3154231 NCOR2 NM_006312
Homo sapiens Kruppel-like factor GCCCTTCACCATTGTGGAATGATGCCCTG
BTEB, BTEB1
0592 23360227 24908511 147 3393 KLF9 NM 001206 9 (KLF9), mRNA GCTTTAAGGTTTAGCTCCACA
Fold
Synonyms Description Probe_Sequence Probe Id Probβ SequβnceJ
Change XS No GFs pOS β GFs pOS No GFs Common Genbank
Homo sapiens IKK interacting
CTGGAGTTAGGAGGGCCTGTGGTAGACA
FLJ31051 protein (IKIP)1 transcript variant GCGTGAATCATGAAAATAAGCC
0 59 25489346 4905476 28943927 IKIP NM 153687 1, mRNA
Homo sapiens Faπconi anemia,
GCTTCCAGAATTTATAACACAT
FAAP95, FA2, FACB, FAB, complementation group B TGCAGAGGTGTGAAGTGAGCAAAGGAAA GAGCCCCCAAAAAGCCGGGAC ILMNJ 733538 FAAP90 (FANCB), transcript variant 2, GAGTAGTGTCGTCGCGGCTGCT TGGCAGC
0585 13217771 10341846 60386013 FANCB NM 152633 mRNA
Homo sapiens SUMO1/sentrin
TCGGGGTCAGTTAAGCCTCAGTATTCTTA
KIAA1707, MGC157730 specific peptidase 7 (SENP7), GCTTTTGTTGATTTTGGCACT
0 584 9697266 133 5893 78 12309 SENP7 NM 001077203 transcript variant 2, mRNA
MGC176680, KIAA0662, Homo sapiens PHD finger protein CCATTACCTGGATGTTTTTGTCCACTGGG GRC5, JHDM1E 2 (PHF2), mRNA AGAGGCAGCTTGGTGGAGGCC
0582 156 11429 16743927 97 37263 PHF2 NM 005392
Homo sapiens c-abl oncogene 1 ACAGGCGTCCCATGTGAAGCC
JTK7, ABL, p150, bcr/abl, CCTGTGGTGGCTCCCCCTCTGCTTCTCG receptor tyrosine kinase (ABL1 ), TGCCCAAGTAACTGTGAAGAC ILMNJ758212 v-abl, c-ABL GGGTCCAGTGCATTTTGTTTCT transcript variant a, mRNA AAACTTTG
0 575 6477893 56403094 324 13928 ABL1 NM 005157
Homo sapiens zinc finger protein CCTAGGCTGTTGGTGTACAGAGACCAGA
FLJ14855, FLJ12515 502 (ZNF502), mRNA GGAGAGAGACACACTAGGACTA
0573 96330956 88 185196 5041118 ZNF502 NM 033210
Homo sapiens heparan sulfate
GGCCGCCATTGAAGCCACAGG
(glucosamine) 3-0- TGTTCTCACTCCCGCCCCATCTTAATGTA
3OST3A1. 30ST3A1 CGCAGTGATCCATTTTGGCAA ILMNJ 806647 sulfotransferase 3A1 TAACCAACACCAAACACGTGG CGGGAAGT
0 572 864 3726 5135048 2933 181 HS3ST3A1 NM 006042 (HS3ST3A1), mRNA
GBF, ZF9, ST12, CPBP, Homo sapiens Kruppel-like factor
CCCTTCCGAGCGGCGCCTAAGCCTTTGC BCD1, COPEB, PAC1, 6 (KLF6), transcript variant 2, CGTGAGCATGCACACTGAGAAT
0571 39399976 4581 7393 26154644 KLF6 DKFZp686N0199 NM 001300 mRNA
MGC149865, Homo sapiens ankyrin repeat
AAAGGACTGCCCTACATTTGGCCTGTGCC MGC167812, FLJ21281, domain 36B (ANKRD36B), ACTGGCCAACCGGAAATGGTA FLJ90089, MGC 149864 mRNA
0568 4961931 6860441 3891951 ANKRD36B NM 025190
Homo sapiens solute carrier
DKFZp686K15246, family 7 (cationic amino acid
ACACCAAGGCAGTCAGTTAAGGCAGCTAT KIAA0245, LAT3, LAT-2, transporter, y+ system), member GGTTTGGAAAGGCATACGGAC y+LAT-2 6 (SLC7A6), transcript variant 2,
0563 18346011 22059761 12434762 SLC7A6 NM_001076785 mRNA
Homo sapiens transgelin 2 TGTGTCCTCCGTTCATTCCATGGCTGGGA
KIAA0120, HA1756
0563 5805014 8462 248 4761 381 TAGLN2 NM 003564 (TAGLN2), mRNA GTCACTGATGCTGCCTCTGCC
TNRC14, SMRTE-tau, Homo sapiens nuclear receptor
CGTTGCCGCAGCGGTGGGAAGGAAAGGC SMRT, TRAC 1. CTG26, co-reprβssor 2 (NCOR2), AGATGTAAATGATGTGTTGGTT SMRTE, TRAC-1 transcript variant 2, mRNA
0563 1405 5642 18058976 101673096 NCOR2 NM 001077261
OSMRB, MGC75127, Homo sapiens oncostatin M GCAGGATCATGGGAGCATGCTTACCTTCT MGC150626, MGC150627 receptor (OSMR), mRNA GCTGTTTGTTCCAGGCTCACC
0 559 12795595 7358258 41 085552 OSMR NM 003999
Homo sapiens major facilitator
GCAGAGATGTGTTGGGTTTGGTGGTGCA
FLJ22196, ET, FLJ20226 superfamily domain containing 11 TGCCTGTGATCCTAGCTGCTGG
0559 562 3059 34530597 19300595 MFSD11 NM 024311 (MFSD11), mRNA
Homo sapiens hexosaminidase A
AGGCTGGAGTCAGTGTCTGCCCCTGAGG
TSD, MGC99608 (alpha polypeptide) (HEXA), TCTTTTAAGTTGAGGGCTGGGA
0 559 86278076 63202793 35 33599 HEXA NM 000520 mRNA
Fold
Synonyms Description Probe_Sequeπce Probe Id Probe_Sequence_l
Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
Homo sapiens TNF receptor-
CCGCCTTGTGCTAGTGCCCTCGAGAAGA
MGC 3310, RNF85 associated factor 6 (TRAF6), GTTATTGCTCTAGAAAGTTGAG
0555 75219696 9731845 54024055 TRAF6 NM 145803 transcript variant 1 , mRNA Homo sapiens inositol 1 ,4,5- GCCCATTATAGCCTCTGAATTG
AGCTACTGGTACTCCCCAGCACCACCTCA
IP3R2 triphosphate receptor, type 2 TCCCTTCCTTGAGTTTGCTAAT ILMN_1732815 TACTAAGAATTCCTCACTCTG
0549 57270725 8469768 4647178 ITPR2 NM 002223 (ITPR2), mRNA GCTTCC Homo sapiens solute carrier
MPE16, CD98, 4F2LC, CTAAGTACGATGTTCAAGTGAG family 7 (cattonic amino acid AGGCTGGACACCCTCTGCCGAGTAATGA hLAT1, D16S469E, LAT1, AGCAGCAGTGAGCTCCATGTG ILMNJ 756455 transporter, y+ system), member CGTGTGTGGCTGGGACCTTCTT E16 CAGAGAG
0547 21679226 10810642 59146844 SLC7A5 NM 003486 5 (SLC7A5), mRNA Homo sapiens synaptosomal-
AGGCGGCGAGGCCACCACAC
SNAP23A, SNAP23B, associated protein, 23kDa GCATCTGAACACTTCAAAGCTGTCAGTGT
CTGCAGAGCGCTCGGGCTGCC ILMN_1700037 HST17016 (SNAP23), transcript variant 1, GTATTGGTTTCACCAATAACC TAGCCGGCA
0546 2888393 39226428 21423096 SNAP23 NM 003825 mRNA
Homo sapiens family with TGGGAGGATCGCCTGAGCCCA
ACTTCCTGGGAGTGACCCAGCGTTATTCC
MGC 16044 sequence similarity 113, member GGGAGGTCAAGGCTGCAGTGA ILMN_1713706 TGCCTCCTCACTCCTATTCTC
B (FAM113B), mRNA GCAATGAT
0545 86697655 7968948 4348703 FAM113B NM 138371
Homo sapiens ATPase, Na+/K+
CTCCCCACCCATTCCTTTAAAT transporting, beta 1 polypeptide GCTGTGTCTGAGATCTGGATCTGCCCATC MGC1798, ATP1B CCGGAGGGGGAAAAAATCCCA ILMNJ 667831 (ATP1B1), transcript variant 1, ACTTTGGCTAGTGACAGGGCT AGGTCTG
0543 29932263 5838893 31655176 ATP1B1 NM 001677 mRNA
CAGH16, TNRC14, pCIP, ACTR, AIB-1. CTG26, Homo sapiens nuclear receptor
CCACATGAAATGACTTATGGGGGATGGTG MGC141848, TRAM-1, reactivator 3 (NCOA3), transcript AGCTGTGACTGCTTTGCTGAC TNRC16, AIB1. SRC3, variant 1 , mRNA SRC-1. RAC3
0543 74011426 55586426 30165594 NCOA3 NM 181659
Homo sapiens zinc finger, DHHC- TGTCAGGACGCGGAAAGCAGG
GGACAGGATTCGATTAAGTATTCCCTCTT
ZNF372 type containing 2 (ZDHHC2), GAGGCAAGGCCCGCGCTAAG ILMNJ 747589 GTCAAACTGGAAGCTAGGGGA
0541 49395973 12539345 6778848 ZDHHC2 NM 016353 mRNA GCCAAGTCG
FLJ31074, MGC111533, GGATGTGATCCCCTGGATTCC
Homo sapiens anthrax toxin TGGCGGGCATGTGAGTGCACAAGATGGA CMG-2, MGC45856, JHF, CAAAGCCCAGAAGGAGATTTG ILMNJ 744701 receptor 2 (ANTXR2), mRNA AAGAGCGATTGGAGCATCCTGG
0541 11087643 31483809 17000894 ANTXR2 CMG2, ISH NM 058172 CAAGATGC
Homo sapiens CCAAT/enhancer
CGTTTCCCAGTCCCCATTAGAGGGCTTGA
GPE1BP, IG/EBP-1 binding protein (C/EBP), gamma GACCTTGTACCTGAACAACCC (CEBPG), mRNA
054 55688513 42359344 22894762 CEBPG NM 001806
GGCCACCATCACAATACTAAG
WS2D, SLUG, SLUGH1, Homo sapiens snail homolog 2 AGGATTTCCCATAGGAAGAGATCTGCCAG GGGCTCAGATGTGTCTTGTGC ILMNJ 804445 MGC10182 (Drosophtla) (SNAI2), mRNA ACGCGAACTCAGGTGCCTTAA
0538 14699976 17491726 9407143 SNAI2 NM 003068 CCACCTCT
Homo sapiens integrin, alpha V
GGCTGAGATGGTGGACTTCTT
CD51, DKFZp686A08142, (vitronectin receptor, alpha AGTCGTTCTTGGAATACCTATGTGCAGCC CTTGGCCCTCATGGTCATTGC ILMNJ683046 VNRA, MSK8 polypeptide, antigen CD51 ) ACTACCCATCTCAATGTCACC TATTCCTC
0536 15177976 9765768 52419763 ITGAV NM 002210 (ITGAV), mRNA
Homo sapiens kelch-like 2, GTGAGTACTCCACAGTTTACTG
ABP-KELCH, MAV, CCACTTCTGAGGAATGGACCTGGTGTAAC
Mayven (Drosophila) (KLHL2), GGGGAAAAGGCTTCAGTAAAG ILMNJ813100 MAYVEN ACACTTGAATATGTGTGATGC
0533 10752678 22186845 11789761 KLHL2 NM 007246 mRNA CAGAGGC
Homo sapiens myocyte enhancer TCTTCCTGGGTCCTGGGGCAGGGCGAGT
DKFZp686l1536 factor 2D (MEF2D), mRNA CCAAGTGTGAGGCTGTTGATTT
0532 27166846 27870596 14808095 MEF2D NM 005920
Fold ommon Synonyms Gβnbank Description Probe Sequencβ Probejd Probθ_Sβquencθ_l
Change XS No GFs pOS 6 GFs pOS No GFs C
Homo sapiens transmembrane A (TMEM200A), TGCCTTGAAGTTTACCTTGTGCTGGAGAG
TTMC protein 200 CCTTATGATAACTCCAAAGAC
0 528 789 5018 29906978 15809976 TMEM200A NM_052913 mRNA
ATR, FLJ21776, Homo sapiens anthrax toxin CCCAGAAGAACCTCAGGAGGT
ACCATGCTATAGGAGACTGGGCAAAACCT
FLJ11298, TEM8, receptor 1 (ANTXR1 ), transcript AACCTTGGGCCCTTCCCTGCT ILMNJ 796210 GTACAATGACAACCCTGGAAG
0527 2872831 2411 5227 12707393 ANTXR1 FLJ10601 NM_032208 variant 1 , mRNA ATCCT
Homo sapiens patatin-like CACGGCCATTAAAGCTTCCCA
IPLA2G, IPLA2(GAMMA), GGTGAAGTTCCAGTCAACCAC I I I I IACC phosphohpasβ domain containing CAGACACTGGTCGCTGGGCCT ILMNJ 722906 IPLA2-2 CCTGAAATTTCAAGATAATGC
8 (PNPLA8), mRNA GTGCCAGC
0523 125 51012 12836845 6695981 PNPLA8 NM 015723
Homo sapiens solute carrier GCAGCTGTTGGGATGTGTACA
TCTTCGTGGCCTCAATGCCCTCCTTTATC hCTR2, CTR2, COPT2 family 31 (copper transporters), TCGTGAAGCCCACCTGGTGGC ILMNJ692169 CTCATCTTTCTTCTATGCAGA member 2 (SLC31 A2), mRNA CGTGGTTA
0 522 104 37263 34506845 1802351 SLC31A2 NM 001860
Homo sapiens hypothetical
LOC401357 (LOC401357), CTCGGAATCACAGCAGACTCTCCACGCC
CAGCTAGCTCTCGCCTCACTGT
0522 6567034 61 468407 32 002617 LOC401357 NM 001013685 mRNA
Homo sapiens potassium
GAGGATGCTACCAGTTTCGGT inwardly-rectifying channel, uKATP-1, KIR6 1 AGAGTATGATTGCCTCGTTCAA 682987 GTCGGTGACTCCTGAAGGTTTCCTGGTCC subfamily J, member 8 (KCNJ8), TGTGGCG ATCTCATTGCGGCCTGTTGGG
0518 12805595 3297768 1709226 KCNJB NM_004982 mRNA
FILGAP, p73RhoGAP, Homo sapiens Rho GTPase
GGTGATGCCTCGCGTACAGGA FLJ33877, RC-GAP72, activating protein 24 TCTGGTTACCTGTGCAGTTGT ILMN 1703006 GGATTCAGTGAGCCTGCTTTCGCCTGCTG DKFZP564B1162, p73, (ARHGAP24), transcript variant TCTCTGATGGCTCTGGCAAGG GAATACCC
0512 352 8643 4053643 20688512 ARHGAP24 RCGAP72 NM_031305 2, mRNA
PREDICTED Homo sapiens CCATTTAGTCCCCCATCAGAAC membrane-associated ring finger AGAGGTCAGGAATTTAGCTGG ILMNJ658815 GGTAGCCTGAGTGGTC I 1 1 I L CATCTCTT (C3HC4) 3 (MARCH3), mRNA GGAGCCT TCGCGTCCATTACTCAAGGAG
0 506 84 17299 973 19763 4932893 Mar-03 XM_001127871
Homo sapiens follistatin-like 1 ACTAGGTTTGGTTCCTTCAGCCCTCTAAA
FRP, FSL1
0497 7778 756 6459706 32054893 FSTL1 NM 007085 (FSTL1), mRNA AGCATAGGGCTTAGCCTGCAG
Homo sapiens secreted protein, AGGATTGTCCTGACTCACTAAA
ON acidic, cysteiπe-πch (osteonectin) GATGCCAGGATATTGGGGCTG ILMNJ 761580 CGCAGCTCCCCAATCACACTAGCAACATT
(SPARC), mRNA AGGGGAG TCAAGTGCTTGAGAGCCATGC
0494 12073348 65452393 32424727 SPARC NM_003118
Homo sapiens cadheπn 13, H- CAGTGGAGAACCAAGCCCCAT
CDHH cadherιn (heart) (CDH13), GGCCTCAGAATTTCCCCCCAG ILMNJ 700770 AGTGACAGCTTGTGGCTΠTTATTAGAGC
0493 19623096 4187893 206 35178 CDH 13 NM_001257 mRNA TTCCCCAA TCGCCACGAACTAGGGTAAGG
NSLP1 , FKLF2, RFLAT-1, Homo sapiens Kruppel-like factor TTGCTTGTGTGCATGTGTTGGGTGCATGC 0492 39927264 48323096 237 52261 KLF13 BTEB3, RFLAT1 NM_015995 13 (KLF13), mRNA TTCCGGGTCTCAGCTGCCCCA
Homo sapiens SUMO1 /sentrin GGAGGGCTGGAATCTGTCTTC
MGC27076, FLJ42398 specific peptidase 5 (SENP5), CCTGACTCGGCTCCTCAGGTC ILMNJ711786 ACATGCCCCGAGTGCGGAAGAGGATTTA
049 58259773 170 37262 83435196 SENP5 NM_152699 mRNA TTTAGCCT CAAGGAGCTATGTGAGTGCCGG
Homo sapiens transmembrane CCCTGGGGAAATTGATGGGTGTGGCAGT
MGC104751 protein 16F (TMEM16F), mRNA 346 261 70596 TMEM16F NM_001025356 GGACCTGTGAAGAGGGAGAATC
0488 6574393 53554
GTTGACATCCAAATCTAGCCAG
Homo sapiens collagen, type V,
MGC105115 GAGCATCGTTCCAATGCTTGTTCACTGTT AGCCCTTCACTGCCATGATAG ILMNJ694240 alpha 2 (COL5A2), mRNA
0488 8510 98 37598142 18382726 COL5A2 NM_000393 CTGGGGC CCTCTGTCATACTGTATCTGG
Homo sapiens golgi transport 1
GOT1. YMR292W, CGI- homolog B (S cerevisiae) GGGTTTGATAATCTCCCAGTCCTTAGTAA
141
0473 427 94763 7824435 369 5226 GOLT1B NM 016072 (GOLT1B), mRNA AGATTGAGAGAGGCTGGAGCA
Fold
Synonyms Gβnbank Description Probe_Sequence Probejd Probe_Sequence_l
Change XS No GFs pOS 6 GFs pOS No GFs Common
Homo sapiens ATH1 , acid AAAGCCGGTGCAGGCTCTGCT
MGC129858, FLJ22635, AATCCCAGGCTCCTCTTGACTCTGGGCAG trehalase-hke 1 (yeast) (ATHL1), GTCATCGTCAGGACTCCTTGT ILMN_1760049 9 CTTTAATCAGGTTGGGCAGCC
047 14393094 23748478 11 128967 ATHL1 MGC12985 mRNA GGGCTGTG
P120RASGAP, CMAVM,
Homo sapiens RAS p21 protein
RASGAP, activator (GTPase activating GTGCTACCCCTTTGATTATGCAGACAACC
DKFZp434N071, CM-AVM, protein) 1 (RASA1), transcript TCATCAGCTGCCTAACTTATC
RASA, PKWS, GAP, variant 1 , mRNA
0467 1096481 27330562 12774559 RASA1 P120GAP NMJJ02890
CTACCCTCATTAACAATTAGCA
Homo sapiens uπdine-cytidinβ TCTCAACGGCTACACCCCTTCACGCAAGA
UK, TSA903, UMPK GGGCACTGGCCAGAGTTTGTA ILMN_1703487 kinase 2 (UCK2), mRNA GGCAGGCATCGGAGTCCAGCA
0467 678 9976 2688 1726 1252 8643 UCK2 NM 012474 CCCTGTG
Homo sapiens tyrosylprotein GGCTGGAGCTGGGAGAGGTG
GCTCTTGATCCCGATTTCATGCACAGCCC sulfotransferase 1 (TPST1), CTGAGCTAACAGTGCCAACAA ILMN_1731064 TGCAGTAAGGAGCCCAGAAGG
046 30074347 567 7268 261 30597 TPST1 NM_003596 mRNA GTGCTCCTT
TPM1-alpha, TMSA, HTM- Homo sapiens tropomyosin 1 TAAACACTCACCCCTGTCAGC
GGAGGCTGAGACTCGGGCTGAGTTTGCG alpha, TPM1 -kappa, (alpha) (TPM1), transcript variant GTGCGGCTGGGCTCTCAGGAT ILMN_1665932 GAGAGGTCAGTAACTAAATTGG
0456 21859988 19278 182 8799223 TPM1 C15orf13 NM_001018004 3, mRNA AAACTCAC
Homo sapiens collagen, type V, GTTCCAAGGTAAGCCTCGTAAAGGTCATC
0456 8407 689 5262 2393 23987976 COL5A1 NM_000093 alpha 1 (COL5A1 ), mRNA CCACCATCACCAAAGCCTCCG
CAAAGAGAATTGTGGCAGATG
Homo sapiens transmembrane GTCATTCACAGGGGCGGCCGGTCTCCAA
KIAA1623 TTGTGTGTGAACTGTTGTTTCT ILMN_1698220 protein 16H (TMEM16H), mRNA AATGCAAAATGCGCTTCAGCCC
0455 3923884 6741689 30698576 TMEM16H NM_020959 TTGCCAC
Homo sapiens CDC42 effector GTCTTAAGGAGACTGGTAGGA
MGC21945, CEP5, Borg3, CTTCCCGCCCGGCACCCCACTTCTGTATA protein (Rho GTPase binding) 5 GGAGGCATGGAAACCAAAAGG ILMN_1705685 MGC71153 CATAAACGGCCAAGGTGTGTG
(CDC42EP5), mRNA CCGTGTGT
045 15659392 17059344 7672356 CDC42EP5 NM_145057
, , , , . CAGCGGGCTACCCTGGACAAA
LKLF Hcmo sapiens Kruppel-like factor GTAAAGGTGGAAACTAGGTGA ,LMN_1794106 ATTACTGTACATAGAGAGACAGGTGGGCA
2 (lung) (KLF2), mRNA I I I I I GGGCTACCTGGTTCGT
0443 19145476 44502476 1975 1143 KLF2 NM_016270 TGTGGCCT
Homo sapiens protein
NKIP1, IASPP, RAI1 IASPP phosphatase 1 , regulatory CAGATCCCGTCCAAAGTGCCTCCCATGCC gene (inhibitor) subunit 13 like TACCACCATCATCACATCCCC
0423 266 3018 2926726 123 93095 PPP1R13L NM_006663 (PPP1R13L), mRNA
Homo sapiens paired related GTCCAGTTTTGTGTGCTTTACT
GATGCCTTCTGGATCTTAAGCCAGTTGTC
PRX1, PMX1, PHOX1 homeobox 1 (PRRX1), transcript ACACAGTTTGGTTACAGGACTT ILMN_1807735 AGTGGAGGTCCTCAGGGCTGC variant pmx-1 a, mRNA CTGTGC
0418 5296923 5980431 2503456 PRRX1 NM_006902
Homo sapiens basic leucine GCAGTGATCAGGGTCCTGCAA
JEM1, JEM-1, GOLGIN-45, GGGTATGTTAGAAAAACAAAAAGGAGGCT zipper nuclear factor 1 (JEM-1) GCAGTGGGGAAGGGGGCCAA ILMN_1812226 MGC22497. JEM-1S NM 003666 GGGCATGGTGGCTCATGCCTC
0418 16305595 161 33095 67 1759 BLZF1 (BLZF1), mRNA GGTATTGGA
Homo sapiens nicotinamide N- TACCCTTCATGAGACCCAACTC
CAAGGGTCCAGAGAAGGAGGAGAAGTTG methyltransferase (NNMT), TGCCACAGCTCATCCTCGGAG ILMNJ697975 AGACAGGCGGTCAAGCAGGTGC
0417 1307 281 4596601 191 45178 NNMT NM_006169 mRNA GCAATCC
TPM1 -alpha, TMSA, HTM- Homo sapiens tropomyosin 1
AGAGATCAAGGTCCTTTCCGACAAGCTGA alpha, TPM1 -kappa, (alpha) (TPM1), transcript variant AGGAGGCTGAGACTCGGGCTG
041 14946689 14201 84 5822 3057 TPM1 C15orf13 NM_001018020 7, mRNA
Homo sapiens opposite strand CGAGAAGCAGATGACAGGCTC
ACACCTTGTAAGTGTCCCCTCTGGTTTCC
DKFZp686B07267 transcription unit to STAG3 AGGCCTTACCAGGGATGCACT ILMNJ 725633 TCGGTGGTGGCGCCCTGAACT
041 77 18435 132048435 5 3930697 GATS NM 178831 (GATS), mRNA TGCCACAT
Homo sapiens lines homolog 1
ACACCAGCAAGCAACTAAGGAGATTCAGG FLJ10583, WINS1 (Drosophila) (LINS1), transcript ATGCAGCTGGGACAAGCAGGG
0409 5064293 53 751915 21 96643 LINS1 NM 001040614 variant 4, mRNA
Fold
Synonyms Description Probe_Sequence Probe Id Probβ SβquenceJ
Change XS No GFs pOS β GFs pOS No GFs Common Gβnbank
PREDICTED Homo sapiens
CAGCTCTGGAACAATTCCTGTC membrane bound O- TGGCCACAGGAGCTGAAAGCAGAAGAGT TGGAGGCCGAGCATGTGGGCA ILMNJ 726328 acyltransferase domain GGGATTTGATGCCAGGCAGTGG GAAACCT containing 2 (MBOAT2), mRNA
04 46980003 102 089294 4062928 MBOAT2 XM 001129292
Homo sapiens zinc finger, SWIM- GCCCCAGATCCCGGGCTTGTG
GAGACTGGGGTGCATCTCCAGAGCCACT type containing 4 (ZSWIM4), GGACACCTATGAAGATGACAT ILMNJ 763520 CACACCCTCAACCTCGTTTCCT
0 39 4394643 247 0476 96 17679 ZSWIM4 NM 023072 mRNA CTCGGAAA
Homo sapiens chromosome 16
FLJ20898, MGC111564, TCCAGCTTTCCTGGTTAGCGCAACGCGG open reading frame 30 CLP24 CTCCACGACCACACGCACTTCA
0387 199 11429 42203928 163 39761 C16ORF30 NM 024600 (C16orf30), mRNA
Homo sapiens protein tyrosine CTATCTCAGTGCCTTCACACAG
R-PTP-GAMMA, HPTPG, ACAGACTAGCAGGCTACTGGGACCTAAAA phosphatase, receptor type, G CCAGCCTGTCCCCGAGTCTCA ILMNJ 767070 RPTPG, PTPG AGGTCTGTTAATGTCATGGCC
0385 96677475 131 52261 5067811 PTPRG NM 002841 (PTPRG), mRNA CCAGTGA
Homo sapiens chromosome 14 AAGCACATTCCTGCCTCAGGG
AGTGTCTAAGAACGTATTCCCTTTACACG
C14orf61 open reading frame 145 CCTTTGTACCTGTTGTTCCCTC ILMNJ 778382 CTGATCTCCTAGTGGAGAAGG
0384 12405609 16394762 62 987476 C14ORF145 NM 152446 (C14orf145), mRNA CACCTGG
Homo sapiens chromosome 11 CATTCAAGAGCTGGCCCCCAA
AGTAGCTCCACCTGAAGAGGGATGGAAC
FN5 open reading frame 75 GTATGCAGCGACACACCCCAA ILMNJ 687291
CTCTGGGTCAGGAAACAGCTGG
0 383 111 435135 960518 36861046 C11ORF75 NM 020179 (C11orf75), mRNA AACAGAGC
Homo sapiens roundabout, axon
FLJ21882, SAX3, guidance receptor, homolog 1 GTATCAGGTCTGACCCCAGTGGAAAACAA MGC131599, DUTT1, (Drosophila) (ROBO1), transcript AGCCAAACAAAACTGAACCAC MGC133277 variant 2, mRNA
0 378 120 17262 18976428 71 86996 ROBO1 NM 133631
MGC23045, GDNFRA, Homo sapiens GDNF family GATCCTGTCCAGAGGCTTCAG
GGGGCTTCTGTGAAAAACCTGATGCAGT RETL1. GFR-ALPHA-1, receptor alpha 1 (GFRA1), GCATACACGGCCACCGAGCAG ILMNJ677542 GCTCCATCCAAACTCAGAAGGC
0 376 12500597 18436693 6951079 GFRA1 RET1L, GDNFR, TRNR1 NM 005264 transcript variant 1 , mRNA GAGATGCA Homo sapiens mucosa associated lymphoid tissue GTTTTGTGGGTCTGCCCTGAG
DKFZp434L132, MLT, TCCCCTTAAGATTGGGAAGAAGGACAAGG lymphoma translocation gene 1 CTGTGCCTGTGTGCTCCAGCC ILMNJ717029 MLT1 ATGTTCACTCGGCACTACTTC (MALT1), transcript variant 1, TCTTCCTA
0374 2948351 41632263 15589761 MALT1 NM 006785 mRNA c14_5320, MGC17921, Homo sapiens FERM domain TGTCTGTGCTGTCCCTCCTGTGCTGGGTC C14orf31, Willin containing 6 (FRMD6), mRNA GCGGATGTGTAGGCAACATTG
0 368 5080.606 8171 2974 30056309 FRMD6 NM 152330
Homo sapiens splA/ryanodine
GTACAGATCCCAGCTTATGGCCTTGACCC
SSB1. SSB-1 receptor domain and SOCS box AGCCGTCCTCACAGATGCCGG containing 1 (SPSB1), mRNA
0365 27520593 37744345 13862262 SPSB1 NM 025106
Homo sapiens NUAK family, GACCCTGCTGCGTCTCCCTTC
GGTTTGAGCCCAGAACAGCCTACAGGGG
KIAA0537, ARK5 SNFMikθ kinase, 1 (NUAK1), CAAACTCTGGTGCTGAATAAAC ILMNJ 789627 AAAAACAAGCTGGATAACCACC
036 692 5226 492 33096 177 57678 NUAK1 NM 014840 mRNA CCTTCTG
Homo sapiens very low density
GAGGTCTAAACAAATAATACCcccGTCGG
FLJ35024, VLDLRCH lipoprotein receptor (VLDLR), transcript variant 2, mRNA AATGGTAACCGAGCCAGCAGC
0343 31378513 82 71024 28358551 VLDLR NM 001018056
Homo sapiens echinoderm
ELP79, EMAPL, EMAP, microtubule associated protein GCAGGGTACACAGGCGTTTCCAAGTTTCA HuEMAP, FLJ45033 like 1 (EML1), transcript variant GTGACACCGTCCTGCCTAACC
0335 14663095 27685178 9327275 EML1 NM 004434 2, mRNA
Fold
Synonyms Qβnbank Description Probe_Sequence Probe_ld Probe_Sequence_l
Change XS No GFs pOS β GFs pOS No GFs Common
CAGCAGAGAGGCCTGTGACAT
Homo sapiens . eashirt zinc finger GGGGCCCTGTACTACTGCCTG ILMN 1687035 GACACCGTAACACACTCTGTGCCCTGTTT
ZNF537, TSH3, KIAA1474 homeobox 3 (TSHZ3), mRNA GTTCCACA GGTTGTTGACAATGAAGCACC
0335 28849344 687 0476 23047678 TSHZ3 NM_020856 EX1, c14_5320, Homo sapiens FERM domain GATGGGTCTCCGGTGTCTTTT
AGATGTAGGGTACAGTGGAACATAAGCAG MGC17921, C14orf31, containing 6 (FRMD6), transcript GCAGCTCACATTGCAGGTGGA ILMNJ685330 TGTTACCCCTGGCTGGGAGTC
0333 2074 331 2805 5225 931 61426 FRMD6 WiIIm NM_152330 variant 2, mRNA TTTGCTGG
DKFZp686K06110, WGN,
Homo sapiens versican (VCAN), CAGCCATAGGTGCAGTTTGCTTCTACATG VERSICAN, PG-M, WGN1, mRNA ATGCTAAAGGCTGCGAATGGG ERVR, CSPG2
0331 36534644 30206392 9993476 VCAN NM 004385
Homo sapiens heme oxygenase TCAAGTATCCTTGTTGACACGGCCATGAC
HO-1, bK286B10 (decyding) 1 (HMOX1), mRNA CACTTTCCCCGTGGGCCATGG
0324 58823096 2998931 978 32263 HMOX1 NM 002133
Homo sapiens formin homology 2 GCACACAGAGCAGGATGCCAT
GTCACCCCATGGCTTGTGTTGCCTGCTAC
Formactιn2, FHOS2 domain containing 3 (FHOD3), GCTGGTGGACATTGAAGACTT ILMNJ 794598 GCATTGACTTGGATCTCCAGG
0312 80300934 12750977 39609344 FHOD3 NM 025135 mRNA GACCAGAC
Homo sapiens kelch repeat and
TCAATGTTCAGTGCTCAGGTATGTAGTAA
TA-KRP, KIAA1842 BTB (POZ) domain containing 8 GTACTGTAGTCCTGTGGGGGC (KBTBD8), mRNA
0 304 16 175488 22796428 69 20842 KBTBD8 NM 032505
TTTTCCATCCCAACATTGATGA
Homo sapiens transmembrane GCCAACCCTGAGCAAGGGAACTCCTCAAA
DKFZp434K2435 AGCGTCAGGAACTGTGTGTCT ILMNJ674633 protein 117 (TMEM117), mRNA AAATCATGCAGCGGAACCTTG
029 114 12262 103 535126 30 38353 TMEM117 NM 032256 AGATGTA
Homo sapiens gremlin 1 , cysteine
MGC126660, GREMLIN, CCTAGCAAGGGCAAGATGAGG knot superfamily, homolog CGGCAAAGAATTATATAGACTATGAGGTA PIG2, DAND2, IHG-2, CAACTGGAACAGGCCTTGTCA ILMNJ 697649
(Xenopus laevιs) (GREM1), CCTTGCTGTGTAGGAGGATGA DRM, CKTSF1B1 GCCAGAAC
0282 29646643 4441 956 1267 0642 GREM1 NM 013372 mRNA hDIP, DIP, Homo sapiens TSC22 domain
GAAGGATGGTGTCCTACTGTGGATGAGG
DKFZp313A1123, DSIPI, family, member 3 (TSC22D3), GATGAACAAGGGGATGGCTTTG
028 55309766 385 24344 106922615 TSC22D3 TSC-22R, GILZ NM 198057 transcript variant 1 , mRNA
Homo sapiens ADAM
GGGCGTTGTGTGTGTCGTGAC
MADDAM, MLTNB, metallopeptidase domain 19 TCCAAGCCCACATTTCCAAAGTCACCCCC TTCGTACCTCTCAAGCCCCTCC ILMNJ679754 FKSG34 (meltrιn beta) (ADAM19), AACGCGTCCTCTCACACCGTC TTGTACT
0279 34385476 11067447 30933477 ADAM19 NM 033274 transcript variant 2, mRNA
AGCAGGATGCAGAGTGCTGTT
IEX-1L, PRG1. IEX1, Homo sapiens immediate early GAGGACGTCCCGGCTGGGATGAAGTCTG CAAGTTTTCCAGTGGGGTCCC ILMNJ 758209 GLY96, DIF-2, IEX-1, DIF2 NM 003897 response 3 (IER3), mRNA GTGGTGGGTCGTAAGTTTAGGA
0278 30722893 8732 48 2444731 IER3 TCAAAGGG
Homo sapiens zinc finger protein GGCCAAGGCGTGTGGATTGCTTGAGCCC
FLJ12606 669 (ZNF669), mRNA AGGAGTTCATAACCAGCCTGGA
0266 16897678 197 30594 52 520416 ZNF669 NM 024804
TATGCGCCATTTCTGCATTCAC
CCN2, MGC102839, Homo sapiens connective tissue TTGCAAAGGGGAGGCATCAGTGTCCTTG
TCTCCCCATCGAAACCAAAGG ILMNJ 754555 IGFBP8, NOV2, HCS24 growth factor (CTGF), mRNA GCAGGCTGATTTCTAGGTAGGA
026 24477 805 29918871 7780639 CTGF NM 001901 ACGGGCC
Homo sapiens interleukin 13 GCTCCTAAACCATTGAGCTAG
GTAACCGGTCTGCTTTTGCGTAAGCCAAA
IL-13R, CD213A2, IL13BP receptor, alpha 2 (IL13RA2), CGATTTCAGACCTAGCAGGGA ILMNJ 801262 CACCTACCCAAAAATGATTCC
0258 4774254 41675177 107 33095 IL13RA2 NM_000640 mRNA AGGTGAAG ATROGIN1, MAFbx, Homo sapiens F-box protein 32 TTGCTCTGTCACCCAGGCTGA
GCTTCCTGGATGAGAAGAGCGGCAGTTT Fbx32, MGC33610, (FBXO32), transcript variant 1, AGTGCAGTGGCACAGTCAGGG ILMNJ 791523 CGTGAGCGACCTCAGCAGTTAC
0254 67783093 244 19762 62 357666 FBXO32 FLJ32424 NM_058229 mRNA CCCATTGC
Fold
Synonyms Description Probe_Sequence Probe Id Probe_Sequence_l
Change XS No GFs pOS 6 GFs pOS No GFs Common Genbank
RNF195, DKFZp434J0617, , . , ° GTCGGTGACTCCTGAAGGTTT
Homo sapiens mex-3 homolog B cCTGGTCCATCTCATTGCGGC ILMN 1735779 GAATGTTCGTGGAAGGGCCAGGAGTTCC RKHD3, MGC117199, (C elβgans) (MEX3B), mRNA TGTGAAACCAGGATACTGCAGC MEX-3B CTGTTGGG
0241 9583521 11258095 27310715 MEX3B NM 032246
Homo sapiens collagen triple
CAGATTACCCAAAAGGAGATGCTTCTACT helix repeat containing 1 GGATGGAATTCAGTTTCTCGC
0239 44086426 459 14346 109 59345 CTHRC1 NM .138455 (CTHRC1), mRNA
Homo sapiens urocortin 2 GAGCTCCAACCAAACTCTGTCCCACTTCA
SRP, URP, UCN-II, UCNI
0238 81 14033 2667976 63 311035 UCN2 NM .033199 (UCN2), mRNA CGCACGGACTGTCCTGGGCAA
Homo sapiens PR domain
MGC118922, BLIMP1, containing 1 , with ZNF domain TCTCTTTTCTGCCTCTTACATGTGAATGTT PRDI-BF1. MGC118925,
(PRDM1), transcript variant 1, GAGCCCACAATCAACAGTGG MGC118924, MGC118923
0233 291 38928 787 48926 182 77261 PRDM1 NM .001198 mRNA
MCPIP, FLJ23231, Homo sapiens zinc finger CCCH- CAGGTGCCCACACCTCCTGAA
AGGCCTCATCTGTGCTCTCGCTGGGCAC dJ423B22 1, RP3- type containing 12A (ZC3H12A), GACTTTGCTG I I I I l GCAACTA ILMN_1676660 GTGGCTTCATGTCAGTAAGCAA
0 198 9203801 49356155 9763102 ZC3H12A 423B22 1 NM .025079 mRNA TGAAGCC
Homo sapiens pre-mRNA GCTGCATTCCATACCTCAGTGA
TTTTCCCCTGTCCCCCAACCCCATCCCCA
MGC9315, FU39024 cleavage factor I, 59 kDa subunit AGAAGCCGAAGGATGCTGACA ILMN_1692121 CCTCCACTTCAGAACATGGCA
0 193 40366806 65490616 12475452 FLJ12529 NM .024811 (FLJ12529), mRNA CACAGTG
Homo sapiens transforming GCCTGTCGGGCCTCCGATTTC
CACGAACCCAAAGGGTACAATGCCAACTT
MGC116892, TGF-beta2 growth factor, beta 2 (TGFB2), ATCCTCAGACGTAATGCTCACC ILMN_1684108 CTGTGCTGGAGCATGCCCGTA
0 16 34335596 202 89761 32 70608 TGFB2 NM .003238 mRNA AACAGCA
Homo sapiens GDNF family CGCCATCTCATATCATGGACTC
GCCGTGGCGAGGGTGGGGACGGGGCCT receptor alpha 4 (GFRA4), CGAAGTAGCCTGTTGCCTCCA ILMN_1720665 CTCTCCGGCTCACCGCCCTCCCG
0 158 19908504 58442833 9299536 GFRA4 NM 145762 transcript variant 2, mRNA AATTTGC
Homo sapiens β-phosphofructo-Σ- CTGATAGACTTTCCTCTAAAAG kιnase/fructose-2,6- CCATTCACTCCAGATTTTACCT ILMN.1730575 GCTGGCGTGCCCATGTTGCAGATATTTTC biphosphatase 4 (PFKFB4), CCGAGTTCCCCAGAATGGATG
GGGGAA mRNA
0 149 258 18927 751 70593 1103143 PFKFB4 NM_004567
TPM1 -alpha, HTM-alpha, Homo sapiens tropomyosin 1 CCCCCAAACTGTCTGACTCTGT
CAGAAGCCCCTGGTTGTCTGAAAGGTATG TPM1 -kappa, TMSA, (alpha) (TPM1 ), transcript variant GTTTCCTGCCCTGAGGAGAGA ILMN_1743966 CTTTACTCAGTCTAATGGTGC
0 137 32057678 16675595 22 763115 TPM1 C15orf13 NM 001018008 6, mRNA GGGGTCA hDIP, DIP, Homo sapiens TSC22 domain GTGCATTGTGCTCTTTCCAAGT
AGGGCCTAACCAGCCTTGGGAGTATTGA
DKFZp313A1123, DSIPI, family, member 3 (TSC22D3), TCAGCAGCAGTTCTATCAGTG ILMN_1718961 CTGGTCCCTTACCTCTTATGGC
0 136 20328928 102697975 13903629 TSC22D3 TSC-22R, GILZ NM 004089 transcript variant 2, mRNA GTGCCAC
Homo sapiens matrix CAGAAGTATGGCCCAGAAGAG
CAGTGGATCATCACAGTTTGAGTTTGACC
SL-2, STMY2 metallopeptιdase 10 (stromelysιn CCCTTGCCCCGCCTGTCTGCC ILMN_1657505 CCAATGCCAGGATGGTGACAC 2) (MMP10), mRNA CTTGGTGG
0 134 10315353 227 28928 29578827 MMP10 NM 002425
CDGG1. EBMD, CSD3, Homo sapiens transforming
CCAGCCTCATGGGAAGTCCTGGCACAGT CSD1. BIGH3, LCD1, growth factor, beta-induced, TTTTGTAAAGCCCTTGCACAGC CSD2, CDG2, CDB1, CSD NM_000358 68kDa (TGFBI), mRNA
0 112 9535772 22431 922 2515 5894 TGFBI
HRG, GGF2, HGL, GGF, Homo sapiens neuregulin 1 TAGAAAGTGTCCCAAAGCAAAT
CTACATCCACCACTGGGACAAGCCATCTT
NDF, HRGA, HRG1, (NRG1), transcript variant GGF2, CCCACCAAGACCACCTGAAGG ILMN_1740449 GTAAAATGTGCGGAGAAGGAG
00899 76926794 13062262 11 550978 NRG1 SMDF, ARIA NM_013962 mRNA TCTCACC
. , GCCCAAGGTAGAGCAGACACT
Homo sapiens co ageα type V, TGAGGAGACCAGCTCAGCAAA ILMN 1730325 GGGACTTCCCTTGACTGGGTTGTGTTTCT alpha 3 (COL5A3), mRNA CGGAAGAC TTTCCTGCCTCAGCCCAGCTC
00806 4351835 110 19345 8816946 COL5A3 NM 015719
Fold
Synonyms Description Probe_Sequence Probe Id Probθ_Sequence_l
Change XS No GFs pOS β GFs pOS No GFs Common Genbank
Homo sapiens solute carrier GCAGCCCCCAGGCCAAAGTCC
FLJ42613, FKSG16, RP11- CTCCTTCCCATCTCATTTCTTACTGCCTTA family 46, member 3 (SLC46A3), TTTCTCACACTCCACTGCCCAA ILMNJ 739887 97E232 CGCTCATCCTGAGGTCCACC
00573 14822263 452 90594 2670903 SLC46A3 NMJ81785 mRNA TAGTGAC
Homo sapiens secretogranin V AGAAGGCTGTACTCAAGAGGAGGAGCTG S9V, 7B2, P7B2, SGNE1 ^0030x
0044 446775 1054 1184 47 015976 SCG5 (7B2 protein) (SCG5), mRNA ACACATTTCACTTGGCTGCGTC
Homo sapiens dapper, antagonist
THYEX3, HDPR1, of beta-catenin, homolog 1 CCTTAAAAGGATTCACAAAAACTTTTGCCA
DAPPER1, FRODO,
(Xβnopus laevis) (DACT1), CACTTGGTGCCTAGGCCCTG
DAPPER. DPR1 m 0,^
00303 37501428 394 06427 11 463751 DACT1 mRNA
TABLE 13 pOS + no GFs
Synonyms Probβ_Sβquβncβ Probe_SequeπceJ Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens dentideless GCCATCTGAACATGCTCT
GGAAGCCATAGAATTGCTCTGGTCAAAACCAAG
DCAF2, CDT2, L2DTL, RAMP homolog (Drosophila) (DTL), CCTGTTGGTGTGTATGT CACACCATAGCCTTAAC mRNA CACTAGGGCAGTGGG
7986569 45932263 387 88928 DTL NM_016448 ILMN 1689642
Homo sapiens NMDA receptor GGAGGAGTGGAAGCTAT
TGCCTCAGCAAGTTCTGTAGAAAATGAGCCGGC
BRCC1 regulated 2 (NARG2), TTTGTATGCAACTAGTCA AGTTAGTTCAGCAACTC transcript variant 1 , mRNA CTGCTGAGGGGTGTC
48 371307 81 43953 77 61078 NARG2 NM_024611 ILMN 1717935
Homo sapiens inhibitor of
CGCTCCAAGGCCAAGCAGGAAAGGGAAGCTTCA
ING1L, p33ING2 growth family, member 2 CCTGTTGAGTTTGCAAT
4826768 791 45593 756 3143 ING2 NM_001564 (ING2), mRNA
MGC102843, DKFZP727C091, Homo sapiens KIAA1267 CCTGCTTTGGAGCTGTGTAATGGCAGCGAAACA DKFZp686P06109 (KIAA1267), mRNA TGTAGCTGTCTTTGTTC
54364343 1223231 11326226 KIAA1267 NM_015443
TGGAGTGGCTAAGCAGG
Homo sapiens NTF2-lιke TTCTGTTGTTGCGGAGACACTGCAGACTCCACT
P 15, MTR2 _ « - ., ,,.,VT.., D_,Λ TTCGGTTACCTGCCCCC export factor 1 (NXT1), mRNA GGCTGACCCCACAACA GTGCCGAGGTTGAACTC
6704976 10366393 1001 0143 NXT1 NM_013248 ILMN 1801146
Homo sapiens leprecan-like 1 CCATGGCCAGGTTGCCTAGGAGTGGGGTCCACT
FLJ10718, MLAT4, P3H2
461 6726 11085643 11139476 LEPREL1 NM_018192 (LEPREL1), mRNA GATGAAAAGAGGTGTTT
Homo sapiens AT hook TGCAACCAGCTTATGAG
ELYS, TMBS62, MSTP108, GGACTCGGTCTAGCAAGGCCATCTTGTTGCCGG containing transcription factor GGCAATGGGGGCACCTA MST108, DKF2p434N093 ACCTTTCTGAACCAAAC 1 (AHCTF1), mRNA AACTCTTGATGAAAGA
110 11012 233 54346 21827261 AHCTF1 NM_015446 ILMN 1656399
Homo sapiens coiled-coil
FLJ40084, HEI-C, FLJ21094, TAGTAAAGTGGCGGGAGCCGCAGCTATGGAGCC domain containing 5 (spindle HsT1461 GCAGGAGGAGAGAGAAA associated) (CCDC5), mRNA
8048529 203 1726 19396011 CCDC5 NM_138443
KIAA1646, dA59H183, hCERK,
Homo sapiens ceramide TGCATTTGTTTATGTAAT dA59H182, FLJ23239, GCTCTGATTTCCGGGGCAGCCTTTCAGATGCGG kinase (CERK), transcript TTCAGGAGGAATACTGAA MGC131878, LK4, FLJ21430, CAGACATACAACACCTG variant 1 , mRNA CATCTGAGTCCTGG DKFZp434E0211
53370593 10042726 951 4435 CERK NM_022766 ILMN 1791466
Homo sapiens PRP31 pre-
CTGGAACCAACTCTGCC
PRP31, RP11, DKFZp566J153, mRNA processing factor 31 GCATGGCTGAGTTCCTCAAGGTCAAGGGCGAGA CTACCTCCCTGCACTAAC NY-BR-99 homolog (S cerβvisiae) AGAGTGGCCTTATGTCC
CAGCTTTGAGGATGG
1463 1393 16790435 1677 656 PRPF31 NM_015629 (PRPF31), mRNA ILMN 1680591
Homo sapiens gastric cancer
RP11-312O7 1. MGC57827, GCATTCAGAGCTACAAAGGAATAGGAAAGTAGG up-regulated-2 (GCUD2), GCUD2 GTAGTGTTGGATTCTGG
45671036 20544762 177 8393 GCUD2 NM_207418 mRNA
Homo sapiens
C20orf154, dJ967N21 5, miπichromosome maintenance
ACCAGCTTCAAACTATGTAAAAGGACTTCACCAA MGC119522, MGC4816, complex component 8 GTTAGGGCCTCCTGGG MGC12866, REC, MGC119523 (MCM8), transcript variant 1,
32657547 142 01428 123718445 MCM8 NM_032485 mRNA
Homo sapiens tubulin, beta 2C CTCGGGGGCTAAAAATGTCCGCCACCTTCATTG
TUBB2
2647281 5440 789 5132 5977 TUBB2C NM_006088 (TUBB2C), mRNA GCAACAGCACGGCCATC
Homo sapiens PDZ binding GACTCTGGTTACAGATTGTCTTGATCTCTTGGAT
Norι-3, SPK, FLJ14385, TOPK
17342262 1037 156 882 8059 PBK NM 018492 kinase (PBK), mRNA CTCCTCAGATCTTTGG
pOS + no GFe
Synonyms Probβ_Sequθncθ Probe_Sequence_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
DKFZp761M0215, RPF1, RP11- AGATCCTGGCTTTCCAG
Homo sapiens bnx domain GGAGAGTATGAATGGGTCCATAAGCCCCGGGAA 118B23 1, DKFZp761G0415, ATGGATACAAGTAGAAG FLJ12475 containing 5 (BXDC5), mRNA ∞™E£∞£S&
33593097 6383101 604 33093 BXDC5 NM 025065 ILMN 1664723
EAP2, AD022, MGC111021 , Homo sapiens TRAF and TNF AGGAGGTGATGCTGGTC
GGCAAAGTTAAGCTTGATGATGGTTAAAATCGGT MGC9099, (JJ30M3 3, RP 1- receptor associated protein CCTGGCCACCTCTACAG TTGATAGCACCATGGG 30M33 (TTRAP), mRNA CCCTGAACTCTTGAGA
71 35876 10789358 101 93515 TTRAP NM 016614 ILMN 1735735
Homo sapiens TRIO and F-
TARA, FLJ39315, KIAA1662, CTCAGGTATGGGAAACT actin binding protein ACAGGGGAGCCTCCAGTAGCCCTCAGAGAATGC dJ37E164, HRIHFB2122, AGGCCGCCCAGTCGCGC (TRIOBP), transcript variant 2, ACCGTCCGCCTAGGACA DFNB28 GCCTCTCCAAAACGTT
10466432 22028094 20679346 TRIOBP NM 138632 mRNA ILMNJ699565
Homo sapiens solute carrier family 25 (mitochondrial carrier, oxoglutarate earner), GGAAACCAAGGCAGAGCTGAGGGGACAGGGAG
SLC20A4, OGC member 11 (SLC25A11), GAGCAGAAGCCATCAAGA nuclear gene encoding mitochondrial protein, mRNA
132 77261 1839018 179 16428 SLC25A11 NM 003562
Homo sapiens chromosome
FLJ38838, FLJ13936, GGCCCACCTTCAGTGTGTGAAACTCGAAGTGCT 11 open reading frame 82 FLJ25416 TGGTCACCTGAATTGTT
6609779 5098393 421 01843 C11ORF82 NM 145018 (C11orf82), mRNA
Homo sapiens heterogeneous GCATGAGGACTTAATGAA nuclear πboπucleoprotein A/B τrrAAArrτGT(rrrATRr GCGGCAGCAGGAGCGACCAACTGATCGCACACA
ABBP1, FU40338 (HNRNPAB). transα,p, vaπan, ^^τ C G C c T A^C c ATGC TGCTTTGTTTGGATATG 2, mRNA
15135643 2691 8394 25702393 HNRNPAB NM 004499 ILMN 1811592
Homo sapiens ubiquitm- conjugattng enzyme E2C CCCTCATGAACCCAACATTGATAGTCCCTTGAAC
UBCH10, 4J447F32 (UBE2C), transcript variant 6, ACACATGCTGCCGAGC
1104 106 3893 0476 3498 181 UBE2C NM 181803 mRNA
Homo sapiens CCCCCTGACATGGAAGA
TGGAGGACTGTGACAGACTTTGGACAGTGGCCT
MGC5097 tetratncopeptide repeat CGATTACGAACCTGAGC CTTGAGTTCCTCTGCAG domain 4 (TTC4), mRNA TGCTGTTAATGCCATC
94048096 1Θ41 3392 17482059 TTC4 NM 004623 ILMN 1661674
Homo sapiens SR-related GGGGCCCATGTTCACAC
CCCTCACCTCTTTGAAACTCTGGACGTATTTATG
SR-A1, SRA1, FLJ00034 CTD-assoαated factor 1 TGGCTCTCAGTCTAGTCA GCTCCACCTCCCCACC (SCAF1), mRNA GGTGCAATGTTCTTG
56023453 81 14087 7763129 SCAF1 NM 021228 ILMN 1813938
Homo sapiens NIMA (never in
NLK1. NEK2A, HsPK 21, CTGTTTAACAGAATATGAGCTGTCTGTCATTTAC mitosis gene a)-related kinase HSPK21 CTACTTCTTTCCCACT
23391429 10137476 906 5143 NEK2 NM 002497 2 (NEK2), mRNA
Homo sapiens malignant fibrous histiocytoma amplified GGAATGGCCTGGACTGCACTACACCGTGCACAT
MASL1. FLJ23354 sequence 1 (MFHAS1 ), TCTCTGTTCTAAGTGCC
21 907574 132 75595 114 33511 MFHAS1 NM 004225 mRNA
Homo sapiens dual specificity
CTCCCTGCCCCTGGAGGTTGTCTTCAAGCTGTG
HVH3, DUSP phosphatase 5 (DUSP5), GACTTCTGGGATTTGCA
56020593 11880476 1144 506 DUSP5 NM 004419 mRNA
pOS * no GFs
Synonyms Probβ_Sβquβncβ Probθ_Sequencθ_l Raw XS pOS + β GFs Raw Raw Common Genbank Description
Homo sapiens timeless CCACTGGTATTCCTGAG
TIM, FLJ12640, TIM1, TGGTCTGTTCCTTTGGCTTTCTCTTGGAGGTGG homolog (Drosophila) CCTCTCCCAGCTCCACTT FLJ20714, hTIM GTCGCAGCACCAGATGG (TIMELESS), mRNA CTAATGCTAGAGAAT
23409344 5864393 54134344 TIMELESS NM 003920 ILMN 1684401
Homo sapiens ubiquitin specific peptidase 16 GAACACAGTGGTACTATGAGGTCGGGGCATTAC
UBP-M (USP16), transcript variant 1, ACTGCCTATGCCAAGGC
47578094 13715143 12727476 USP16 NM 006447 mRNA
Homo sapiens ribosomal RNA GCTAATAGCCTAACTGCA
KIAA0507, CGI-115, CTGCTTGACCAGCGAGATGTGCATTTTGCCAGG processing 15 homolog (S GAGGAACTGAGTGGATG MGC22291 ATCATATTGGTCATGTC cβrevisiae) (RRP15), mRNA GGGTAGCTGCTGTAT
5412101 10609309 100588513 RRP15 NM 016052 ILMN 1790008
Homo sapiens single stranded
TGGGACTCTTCGAAGAC
CSDP, FLJ10355, SSDP1, DNA binding protein 3 ATAAGTGGCATTAGCAATCCTCCAGGCACCCCTC
ACCAATCTGTGCGCTATT SSDP (SSBP3), transcript variant 2, GAGATGACGGCGAGCT
CACGCTAAACGCGTC
8440606 64020593 5602268 SSBP3 NM 018070 mRNA ILMN 1712184
Homo sapiens cornichon
CNIH1. CNIL, TGAM77, ATCTGACTAGTGGGAAACTTCATGGGTTTCCTCA homolog (Drosophila) (CNIH), MGC117156 TCTGTCATGTCGATGA transcript variant 2 mRNA
14369309 19463226 1901406 CNIH NM 001009551
DKFZP547N043, PRO4323,
GGGTGCTACATTCACTCTTGCCTTAGGTATACTG DDDL1880, dJ876B103, RP5- TAACCCAGGTTCTGCC 876B10 3
6372792 15773929 14822263 C1ORF124 NM 001010984
DCHT, PASK, SPAK, CAAGGAGGTGGGCTCCCAGGATGGTACCATTGC DKFZp686K05124 TCTTTCCTAGCTAACCC
8242726 1602881 15241143 STK39 NM 013233
Figure imgf000179_0001
Homo sapiens polymerase
TCCAGAAGTAAGCCAGCTGTGGATCCCGCCCAC
FU37250, FLJ21662 (DNA directed), alpha 2 (7OkD TCAGAAAAGGCGAGAAG subunit) (POLA2), mRNA
23184763 92156433 8246601 P0LA2 NM 002689
Homo sapiens phosphatidylinositol-specific
GTACCCGGTTGCTACGGTGAAATGAAGGTGCCC
LL0XNC01-136G2 1, FLJ11323 phospholipase C, X domain CGCATCCAGAAAGACGC containing 1 (PLCXD1),
9708522 44945593 40353094 PLCXD1 NMJ518390 mRNA
Homo sapiens cyclin A2 CCTTGTCTCATGGACCTTCACCAGACCTACCTCA
CCN1. CCNA
42565594 29387725 25421892 CCNA2 NM 001237 (CCNA2), mRNA AAGCACCACAGCATGC
Homo sapiens polymerase
YBL1, p17, CHARAC17, CTGTTGGCCTTTCTTAGCC I I I I I (DNA directed), epsilon 3 (p17 CHRAC17 CAGTGCTCCAAGCGC subunit) (P0LE3), mRNA
13874226 34330142 32240393 P0LE3 NM 017443
Homo sapiens eukaryotic translation initiation factor 4E CCGGGACACACTTCGGCGAGTGCTTAACCTACC
EIF4EL3, 4E-LP, 4EHP, IF4θ family member 2 (EIF4E2), TCCCAACACCATTATGG
10998726 14089727 13929226 EIF4E2 NM 004846 mRNA
RA-GEF-2, DKFZp686l15116, Homo sapiens Rap guanine CTCTCGCTTGCTCTCTCT
TTCTGCAGCATGCCTCCCCCACATCTCATAGCAC DKFZp667N084, PDZGEF2, nucleotide exchange factor CACCATGTGACACACTG CAGGTTGTGTCTGACC PDZ-GEF2, KIA001LB (GEF) 6 (RAPGEF6), mRNA GCTCCCCTTCACCTT
10809762 20244345 19383511 RAPGEF6 NM_016340 ILMN 1718309
pOS + no GFs
Synonyms Gmbmk Probe_Sequence Probe_Sequence_l Raw XS pOS + β GFs Raw Raw Common Description Probe Id
Homo sapiens nucleolar
ATCACCCGGACACACATCATGCTTAAGATTCAAC
HSPC120 protein NOP5/NOP58 TGGGAGCATACCAGGG
4858226 11096477 1040 1393 NOP5/NOP58 NM 015934 (NOP5/NOP58), mRNA
Homo sapiens cleavage and
HPBRIK HPBRII-7, CFIM, GCACCTGACTAGCATGTGTTCTTGATTGCAAAAT polyadenylation specific factor CFIM68 TGGCAGAGGCAGGGTG 6, 68kDa (CPSF6), mRNA
4602639 67 066345 644395 CPSF6 NM 007007
Homo sapiens anthrax toxin GAGTGGAGAGGTTTCTC
ATR, FLJ21776, FLJ11298, GAAGTTGGCATGAAAGCTGCACTCCAGGTCAGC receptor 1 (ANTXR1), TAGAGGTGTAGGGGACT TEM8, FLJ10601 ATGAACGATGGCCTCTC transcript variant 2, mRNA GGAAACCACATCCAGG
91 26848 131 16428 12830594 ANTXR1 NM 053034 ILMN 1794353
„_,_,, _, GGAGGCTGGCAGGGACA
Homo sapiens SRR1 domain M,TTCCCJAAMGAGGGA AGAAGCTGCCACCAGAGACTAAAGGGAAGGCTG
HC/HCC, SRRU containing (SRRD), mRNA CCAAGCGTCAGCTCC CTATGGAGGAACTACAG
13963928 247 73929 237 26012 SRRD NM 001013694 ILMN 1682444
Homo sapiens COP9 constitutive photomorphogenic GGAGTGTGGAGGGGTC
CCCTGCTGGTGGCTCTGTCCTCTGTTAGGCACC
MOV34-34KD, CSN6 homolog subunit 6 GATGACTTGTGCAGGGT ACACTGGTTGGTCAACT
(Arabidopsis) (COPS6), CATATGGTACCTAAGGG mRNA
72058093 978 506 9580559 COPS6 NM 006833 ILMN 1813768
Homo sapiens deleted in AGTGAGCTGATGTGCCC
XTP6, MGC22430, DLB1, CCTAGGAGGCTAGAAGAGCCAACCAACAGAGAA lymphocytic leukemia, 1 ACCACCGTGTCATGAGA LEUI1 BCMS GGGAAAGCAGTCTGTTC (DLEU1 ) on chromosome 13 GAATGGGTTTACTCTC
42 396423 11461012 105 19762 DLEU1 NR 002605 ILMN 1759232
TCCTTGAAGCAAAAGAGT rane GCCTTCATTGAGCCCCCTGAGAGAATGGAGTTC
PIG17, MGC24415, FLJ90746 Homo sapiens transmemb protein 85 (TMEM85), mRNA AGTGGTGGAGGACTGCT
GGAACCAGCCATTCC
2046706 27487227 26960308 TMEM85 NM 016454 ILMN 1667016
Homo sapiens DEAH (Asp-Glu CCCTCTTCCTCACTGACT
NDH II, LKP, DDX9, RHA, CTCCTTTGGGACGAATCCTGGCTAAACTCCCCAT Ala-His) box polypeptide 9 TCCCCTTGCACAGGGGC NDHII TGAGCCTCGTTTTGGC (DHX9), mRNA TTCTGTTTTATCCCA
30044763 531 756 5142351 DHX9 NM 001357 ILMN 1695135
GAGCAGAATCTCCGGGA
Homo sapiens carbonyl GAACTGACATGGCGGGACCCAAGGCCACCAAGA
CBR, hCBR1 AATGACTTAGTCTGGCCA reductase 1 (CBR1), mRNA GCCCAGAAGAAGGTGCA CATGCATAGCCCATC
184 88095 244 12262 237 01428 CBR1 NM 001757 ILMN 1769720
Homo sapiens mWW* AAGGGGAGTTTACAGAC isomerase (cyclophιlιn)-lιke 3 ArATrRRRR GGAAGAGGAGGCAACAGTATTTGGGGCAAGAAG
CYPJ
(PPIL3), transcript variant ArrrrrrTrr A^r TTTGAGGATGAATACAG
PPIL3b, mRNA ACGCGGCTCCTTTAAG
42 928158 8526502 80 189476 PPIL3 NM 130906 ILMN 1662934
Homo sapiens transmembrane CCGCCTCATTTGCGCCT
GAGAAAGATGGGTTGCTAGAGGATGGTAGAACT
MGC45714, C17orf32 protein 199 (TMEM199), TGCAGCACTGCTGGACC GGAAGCAAGGCAGCTAC mRNA AGGTTACAAGATGTTC
18343929 306 50595 297 05594 TMEM199 NM 152464 ILMN 1723398
KIAA1646, dA59H18 3, hCERK,
Homo sapiens ceramide GGTGATTACCCTGTGTAT dA59H182, FLJ23239, GGGAAAGTCTGAGTGAAAGGATGGCCTCATTCT kinase (CERK), transcript AAGAGTATGTGTCTCACT MGC131878, LK4, FLJ21430, CTTTCTAATCTTGCTGG variant 2, mRNA GCACCTTCAATGGC DKFZp434E0211
470 18927 845 82263 81086426 CERK NM 182661 ILMN 1766176
pOS + no GFs
Synonyms Probe_Sequθπce
Gonbank Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Description Probe Id
Homo sapiens chromosome bA371L19 3, MGC4675, F10, 20 open reading frame 55 CCTTTGCTGACTTCCTCTTCCTTACCCAGCAGAA MGC2450 (C20orf55), transcript variant CTCACCCTGGGGTCGG
80866684 14847263 14520595 C20ORF55 NM 031424 1, mRNA
Homo sapiens CCR4-NOT
TGTGGTGAATGTAACAAT transcription complex, subunit GAACGGATAGGACCACAACATCAGGCAGGATCT
CAF1, hCAF-1 ATATGTTCTTCATATTTA
7 (CNOT7), transcript variant GATTCATTGCTCACAGG
GCCAATATATTAAT
8667476 1267 7142 1227 7144 CNOT7 NM 013354 1, mRNA ILMN 1652376
Homo sapiens SWI/SNF
StMp, SNF2L2, SWI2, related, matrix associated, FLJ36757, SNF2, BAF190, actin dependent regulator of CTTTGCTTTCTTTGCACAATGTCTrTGGTTGCAA MGC74511, BRM, hBRM, chromatin, subfamily a, GTCATAAGCCTGAGGC SNF2LA, hSNF2a member 2 (SMARCA2),
1092 3392 19263226 18935892 SMARCA2 NM 003070 transcript variant 1 , mRNA
PTBLP, nPTB, nPTB7, PTB, Homo sapiens polypynmidine GCTGTGGATTACATCTTG
GTGGCAGTTTTCTAAAACTGACAACCAGGTGGG nPTB8, nPTB6, FLJ34897, tract binding protein 2 TGTGTGTCAGAGAAACT ACCAAAGTTTATGTGCC MIBP, nPTB5, brPTB (PTBP2), mRNA GCAGAGAACCTGGAG
98 13929 1494 8977 13700643 PTBP2 NM 021190 ILMN 1712360
GGACAATGCTGGCCACT
Homo sapiens tubulin, alpha GGAGAGGAATACTAATTATCCATTCCTTTTGGCC
K-ALPHA-1 GCCATTCTGTGTTCAGAA 1b (TUBA1B), mRNA CTGCAGCATGTCATGC AGACTATGAGACCTG
30635855 45105215 44286258 TUBA1B NM 006082 ILMN 1703273
Homo sapiens ubiquitin family TT ATCCAGGC I I I I I GAC
TGGCCCAGGAGACTGACCCAAAGTGAAGGACAT
UBPH, FLJ42145, FLJ38870 domain containing 1 (UBFD1 ), CACGCTATGCTCCAAGC
TGCCGGGAGAGGCCTGC mRNA CCATCGCGCGCACCA
233 58095 59681433 5767643 UBFD1 NM 019116 ILMN 1693617
Homo sapiens xanthine GAATAGGGTCGGGAAGGGTTTGTGCTATTCCCC
XOR, XO dehydrogenase (XDH), mRNA ACTTACTGGACAGCCTG
11 266656 101 42207 87 65945 XDH NM 000379
Homo sapiens small nuclear MGATTGAGAAGAACGG
GGAGCTGCCAGGGATGCTTTACAGGGATTTAAG
MGC45309, MGC24807 rfO"^βlP:Otβ'" PO'yPβPtlde GAAGGTCAGCGGGACCA
B" (SNRPB2), transcript ATCACACCGTCCCATGC
AGAAGGAGAACTGCCC
34130728 41059644 40904976 SNRPB2 NM 198220 variant 2, mRNA ILMN 1726043 Homo sapiens Zwilch,
FLJ10036, FLJ16343, kinetochore associated, CACTACTGCTATCATAAG
TCTCTACTGGCGAAAATGTTGGACCACTTGCTTT KNTC1AP, MGC111034, homolog (Drosophila) GGGTCAGGGACATTCCG ACCAGTTGGGAAGGCA hZwilch (ZWILCH), transcript variant 1, GGGAGAAGTGACCAC
33 57508 187 11845 17323096 ZWILCH NM 017975 mRNA ILMN 1769032
Homo sapiens cytoskeleton ATTCAGTGGAGACTCAG
TTATTGACTTCTCATGTTCTAGAGAGTAGGACTT
TMAP, FLJ10749, LB1, SΘ20-10 associated protein 2 (CKAP2), GAGGAGCCACACCGTGG TTATTCCGTGTACCTG mRNA GAACAGGGCTGATGCT
2690893 814 8143 7728059 CKAP2 NM 018204 ILMN 1716546
Homo sapiens replication factor C (activator 1) 4, 37kDa AGATGAGGGTCATGCAGCAACTCAGCTCGTCAA
A1. RFC37, MGC27291 (RFC4), transcript variant 2, TCAACTCCATGATGTGG
22861844 9050226 84889343 RFC4 NM 181573 mRNA
Homo sapiens tubulin tyrosine TGGGCCACATCCCCTCC
KIAA0998, STAMP, ACCTTCCCTTTGCCCCATGCCCCCAAACTGCTTA hgase-hke family, member 5 ATCTACACAGACACCTGA MGC117189 GGTCTTCTCTGTCCCT (TTLL5), mRNA AGGAGCCCCCACATG
62 354637 98 17263 9860626 TTLL5 NM 015072 ILMN 1736101
pOS ♦ no GFs
Synonyms Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe.Sequence Probe Id
Homo sapiens plecks.πn and CGAAAGCTGCTCTTCAAT
DKFZp761K1423, EFA6R, Sec7 domain containing 3 GAfifiAAGrrATfifif!GAA TTGGGAGCTGAAGAATACTGGACGGGGCTTCGG HCA67 <PSD3). ,ranscπPtvar,an,2, %£%£%£%£?" AGAGGAAGGATGGTCCA
45426586 781189 76198074 PSD3 NM 206909 mRNA ILMN 1772780
Homo sapiens mitochondrial ribosomal protein S2
AGAAGATGCTGCTGTCCCTGTGATCCCAGCAGC
MRP-S2, CGI-91 (MRPS2), nuclear gene CCTCCCTTCACCGTGAC encoding mitochondrial protein, mRNA
33758093 53960596 52834766 MRPS2 NM_016034 DKFZp686K23100, Homo sapiens matπn 3
ATTGTGGGAGTCTCCGCGTCCCGCTCGCTGGGA DKFZp686K0542, KIAA0723, (MATR3), transcript variant 2
GAGAGGTACCTCTCCTT
8065878 8749576 7870299 MATR3 MGC9105 NM_018834 mRNA
Homo sapiens UbiA AAGCTGGGTTGTGTACTT
GGAATGTGATTTGGCAGTCAGGGTACTAAGCAT
RP4-796F18 1. TERE1 prenyltransferase domain TCTGGTGACACTCCTGG GGGTGGGAACTCCTGCC containing 1 (UBIAD1), mRNA GCTCCTCCCCATCCC
110555954 23712677 22832262 UBIAD1 NM 013319 ILMN 1793033
Homo sapiens chromosome CTCAGCTTCCAGCCAAAA
AGCCACCTGGGTCCGGGAGTTGGGGACAGCAG 19 open reading frame 52 TGGCGGAGAACAGCGAG AACGACTTGACACATGTT (C19orf52), mRNA AGTCTGGGCACCGTC
3197226 3887143 38643512 C19ORF52 NM 138358 ILMN 1679687
Homo sapiens high-mobility group (nonhistone ACTGGGAGAGATGTGGAATAACACTGCTGCAGA
HMG1L7, 0J579F20 1 chromosomal) protein 1-lιke 1 TGACAAGCAGCCTGGTG
24897263 65835596 6373393 HMG1L1 NM 001008735 (HMG1L1), mRNA hPIP1, RP11-421M1 5, PIP1, Homo sapiens PAK1 GCCGCAGTGCCCCCCAA
GAGCCTGGTGACACAGTGCACAAAGAAGAAAAG MAK11 , FLJ20624, bA421M1 5, interacting protein 1 CCCAGGCCTCTATTGTTC CGGTCAAAACCTAACAC WDR84 (PAK1IP1), mRNA CATGTTGTAAATACC
13478928 21325177 20860596 PAK1IP1 NM 017906 ILMN 1659823
Homo sapiens cell division
TTCCACTCCTGCCCCGCCTCACCCCACATGCTC
MGC19517, FLJ20764, HEPP cycle associated 4 (CDCA4), CCTGTTTCTCATGCTTT transcript variant 14, mRNA
2941768 96369763 9171101 CDCA4 NM 145701
Homo sapiens ubiquilin 1
DA41. XDRP1, DSK2, GCAGCTATTGAAAGGTTACTGGGCTCCCAGCCA (UBQLN1), transcript variant FLJ90054, PLIC-1 TCATAGCAGCATTTCTG
48437262 84919763 83178094 UBQLN1 NM 053067 2, mRNA Homo sapiens N- deacetylase/N- GGCTTCACATTCACTCCC
HSST2, NCST2, NST2, CTTTAGCCAGGCAGTGGGATCTACCTGTGGCCC sulfotransferase (heparan ATCACCATGACCTTCCCC MGC 129697, MGC 129705 GGCCTCCCTAATGTCAT glucosaminyl) 2 (NDST2), TTCCGTGGATCCCG
14035596 23139761 22991428 NDST2 NM 003635 mRNA ILMN 1793151
Homo sapiens thyroid AGAACAGCCCCATCTCTT
CGGTATGGGCGCCCCTGCATTGCTGGGATGTTT
16E1BP hormone receptor interactor TCGCCTGCACACTTGGA CTGCCCACGGTTTTGTT 13 (TRIP13), mRNA ACTCAGCAAGAAGGG
31260178 12636726 1203281 TRIP13 NM 004237 ILMN 1718783
Homo sapiens non-metastatic
CTTCGGCAGTATCACAA
NDPKA, NM23-H1, NDPK-A, cells 1, protein (NM23A) AAAATGCTTCCTCCCAGCATAGGATTCATTGAGT GAAGATTAAAGTGGCAG NM23, AWD, GAAD expressed in (NME1), TGGTTACTTCATATTG ACACCCCTTCCAGCGG transcript variant 2, mRNA
20343095 4273643 4154226 NME1 NM 000269 ILMN 1702604
pOS + no GFs
Synonyms Probe Sequence Probβ Sequence l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens fructosamιnβ-3- GTAATCTGAACATTTGGG
GGTACATCCAGGAGTCTTCATTGCTTCTGTTATT
FU12171 kinase-related protein AGGCTGAGGCAGGAAGA ACCCCGTCTCCTCTGC
(FN3KRP), mRNA TCGCTTGAGGTCCAG
69557263 926 59766 91246423 FN3KRP NM 024619 ILMN 1811221
Homo sapiens small nuclear ACCCCCGCGCTCCACCT
GGCTGTTCAGCAGAGAAACCCATGTCCTCTCTC
MGC117317, SMG πboπucleoprotein polypeptide GCAGTGTTTCTGCCCTG CATAGGGCCTGTTTTAC G (SNRPG), mRNA TAAATAGGACCAGTCT
4094 1895 7717 1807 75930645 SNRPG NM 003096 ILMN 1659599
Homo sapiens myosin, heavy CTGACAACTGTGAAGCC
NMMHCB, MGC134914, TTCCCCCTTTATGAACTGTACTGGCTGTTGACCA chain 10, non-muscle ACCCTGGGCTACAGAAA MGC134913 CCAGACACCTGACCGC
(MYH10), mRNA CCACAGTCTTCCCAGC
31723228 43138057 42892476 MYH10 NM 005964 ILMN 1713496
Homo sapiens chromosome 7 CGCAGTCATGGATCTGG
GTTGTAGAACACAGGAGCATGCACATTCAGAAAA
GK003 open reading frame 36 GTAGTCCGGAAAACAAA CCCAAGCCCCACATGG (C7orf36), mRNA AGGAGGGAAGACAGCC
27845178 4532351 442 5268 C7ORF36 NM 020192 ILMN 1656826
Homo sapiens E2F
GTCACAGAGCAGCACCT transcription factor 5, p130- CTTCTGACGTGTTTCCTCTCTTAAGGCTTTCTCC
E2F-5 ACCCCCTCCTCCTTTCCA binding (E2F5), transcript TACCCCGGCAGATGAC CACCTGCAAACTCTT
42223907 9326013 9341088 E2F5 NM 001951 variant 1 , mRNA ILMN 1701748
Homo sapiens heterogeneous CATGTCGCATCTG I I I I A
2610510D13Rlk, MGC142030, CGGAGGGAACTTTGGAGGTGGTGGAGGTAATTT nuclear πboπucleoprotein A3 ACTCCAGGCGTGGGGGC D10S102, MGC138232, FBRNP TGGCCGTGGTGGAAACT (HNRNPA3), mRNA TCCTGGGGAAACGAC
133 11429 2699226 273 88928 HNRNPA3 NM 194247 ILMN 1791596
Homo sapiens ATPase, Ca++
DAR, ATP2B, MGC45367, DD, transporting, cardiac muscle, GCTGAACGTGACCCAGTGGCTGATGGTGCTGAA SERCA2 slow twitch 2 (ATP2A2), AATCTCCTTGCCCGTGA transcript variant 1 , mRNA
12709644 34633477 33960977 ATP2A2 NM 170665
Homo sapiens sodium channel, voltage-gated, type ACCAGCTGACACTGCTGAGGAGAAACCCAATGG
Nav1 3, KIAA1356, NAC3 III, alpha subunit (SCN3A), CTACCTAGACTATAGGG transcript variant 1 , mRNA
22933095 312 3643 3066101 SCN3A NM 006922
Homo sapiens chromosome 3
GCCTAGGTGGCTTACCAGCCCAAGTCCCCATGT
MDS027, HSPC300, hHBrki open reading frame 10 TTGGACTTTCAGCTGAC
804 31433 87945593 8758059 C3ORF10 NM 018462 (C3orf10), mRNA Homo sapiens GA binding
NRF2B2, GABPB, E4TF1-47, protein transcription factor, GCCACTAGCACAGGAAG
CTGTGGATGGTGCCATTCAGCAAGTAGTTAGTTC E4TF1, NRF2B1, E4TF1B, beta subunit 2 (GABPB2), CTCAGGACGAAGGCAGC AGGGGGTCAGCAAGTC E4TF1-53, BABPB2, GABPB1 transcript variant gamma-2, GTTAGGAGAATAGTTG
191 83096 706 30597 66023096 GABPB2 NM 016655 mRNA ILMN 1775357
Homo sapiens downstream GGACTTCGAGATCGCAG
B17, C21ort60, TCCTGTTCCGAGCAGCAGGATTAGCTGGAAGTG neighbor of SON (DONSON), CCAAGTACGTGTGTCGG DKFZP434M035 ACTTAATCACAGCTCTC mRNA ACCCTGGAGACACAGC
61 719265 21443929 202 09763 DONSON NM 017613 ILMN 1677955
Homo sapiens transmembrane 9 superfamily member 1 GGTTCCTCCTATCCCCAAGCAGGACTGAGCTTG
HMP70, MP70 (TM9SF1 ), transcript variant 2, AATGATATGAGAGTGTC mRNA
49792515 95 551834 91 747665 TM9SF1 NM 001014842
pOS + no GFs
Synonyms Probe_Sβquencβ Probe_Sθquencβ_l Raw XS pOS + 6 GFs Raw Raw Common Gβnbank Description
Homo sapiens exonuclease 1 GAGTAACGGCTCTGCTG GAAACCCCTGTCCCCAGTCAGAGATAACATCCAA
HEX1, hExol (EXO1 ), transcript variant 1 , CCAGGGTTTCTCTGGGC
CTAACTCCAGAAGCGG mRNA TCATTCTTCCACTGAC
10979465 365 9601 341 88513 EXO1 NM 006027 ILMN 1756669
Homo sapiens adaptor-related GCCAAGAAGAGGCATTT ATGAGTAGGGCTGGGTCTCGGCCATGGAA
BETA-4 protein complex 4, beta 1 CCATGAGCTCTGGACAG CGCA AGCATACCTCAGTGCTC subuπιt (AP4B1), mRNA TGGCAGAGAGGCAGAG
201 79346 297 8476 29534763 AP4B1 NM 006594 ILMN 1702812
Homo sapiens chromosome CACTCCATACAGTATTAG
GCAGGCCAAGCAGGGCAACCCCACACCCTTGAC MGC 13170 19 open reading frame 48 GTGAGGATGGATGCGGG ATAAAAGCATCTTGAAG (C19orf48), mRNA CGCTGTCCTTGCCGG
5590643 1454031 1403006 C19ORF48 NM 199250 ILMN 1651832
Homo sapiens minichromosome maintenance
AGTTGTATAATATGCTTGTAAAGGCTGAGGGTGA
PRO2249, CNA43, MGC126776 complex component 10 GCTGTATCTGGATGCC (MCM10), transcript variant 2,
18402284 86085596 78865594 MCM10 NM 018518 mRNA
Homo sapiens zinc finger ACCCTACCAATGTGAAAAATGTGGCAAAGCTTTT
FLJ31526 protein 681 (ZNF681), mRNA AACCAGTCCTCAAACC
4931388 113 19762 108805954 ZNF681 NM 138286
Homo sapiens πardilysin (N-
CAGCAGTACCTCTTTGACCGCCTTGCCCACGAG hNRD2, hNRD1 arginine dibasic convertase) ATTGAAGCACTGAAGTC (NRD1), mRNA
2301 456 3142 2227 3081 6309 NRD1 NM 002525
Homo sapiens EMG 1 ACAAAAGAGGTCGCTCC
GGTGTCCATCAGTAACTACCCCCTTTCTGCTGCC
Grcc2f, C2F, NEP1 nucleolar protein homolog (S AGCCCTACCACAGGTCT
CTCACCTGTGCAAAAC cerevisiae) (EMG1), mRNA GACTGGCACTGCCTTT
668006 1371 6477 1321 0143 EMG1 NM 006331 ILMN 1732519
Homo sapiens neuropilm GGCAATACCTGATGTCA
FLJ14724, FU10430, NEOT2, GTTCACATCAGTGGCTTTGTATGCAAATATGCTG
(NRP) and tolloid (TLL)-lιke 2 GTCACAGGCATCCAACT FLJ90456 TGTTGGACCTGGACGC (NETO2), mRNA CATGACAAGAGATACC
163 11429 613 5143 584 7726 NETO2 NM_018092 ILMN 1811050
Homo sapiens chromosome Y
CTCTAAAAGAGCCCCAGGAGTCCATCTGGAGGC open reading frame 15B TGACCCCAAAGGAATGA
27 742947 75 85229 71 96585 CYORF15B NMJ332576 (CYorf15B), mRNA Homo sapiens nucleoponπ GCCTTTACACCACCAATCAAAACTCTAGGTACAC
MP44, NP44
579048 22526428 20850179 NUP35 NM_138285 35kDa (NUP35), mRNA CAACACAACCTGGAAG Homo sapiens RecQ protem- like (DNA helicasθ QI -like) TTGGATGGGAAAGGGTGCAGCAAAACTGAGAGT
RβcQ1, RECQL1 (RECQL), transcript variant 2, AGCAGGTGTTGTGGCTC
497 82263 1120 3726 10688142 RECQL NM_032941 mRNA
Homo sapiens SAFB-like,
Met, DKFZp762G052, transcription modulator ATAGCAGGTTCTGGTGATGGTACACAAGAAGTAT FLJ13213, FU10005 (SLTM), transcript variant 1, CTAAACCTCTTCCTTC
7620703 26397263 245 56845 SLTM NM_024755 mRNA
Homo sapiens chromosome
FLJ21832, C10orf2, TWINL, GGGTACCAAGCTCCTCTGCTCCCCACTTTGTAG 10 open reading frame 2 AGCCTAGCATGAGGTGG
48621887 107 44346 1O1 96846 C10ORF2 PEOA3. SANDO, PEO1. PEO NM_021830 (C10orf2), mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sβquence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens spleen focus forming virus (SFFV) proviral
GAGTCTCAAGTCCGTATGTAAATCAGATCTCCCC
SPI-A, OF, SFPH, PLM, SPI-1 integration oncogene spM TCTCACCCCTCCCACC (SPM ), transcript variant 1 ,
8405419 15200595 128 38095 SPM NM 001080547 mRNA
Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), CCTGGAAAAATGGATAAAGGCGAGCACCGTCAG
EWS transcript variant EWS, GAGCGCAGAGATCGGCC
1199 3394 23796309 22806392 EWSR1 NM 005243 mRNA
Homo sapiens anaphase GCTGGTCTGGGTGTAGC
DKFZP564L0562, APC10, CGGCAACTTGAGTTGGTGGAACCAAGTGGCTGG promoting complex subunit 10 TCTTAGAGGAAGGAGAT DOC1 ATTCATGTTCCCTTAAC (ANAPC10), mRNA AGGGAAAAGGGGCTCC
4104226 8457476 81222266 ANAPC10 NM 014885 ILMN 1658027
Homo sapiens eukaryotic
GAATGACATACTGACTGT translation initiation factor 1A GCGTGCTGTAGAATCTCCCATCTCTGAAACAGG TGTTGCTTCTTTCTAGCA domain containing (EIF1 AD), CGTGAAAACCTGTACTG GTGCAGGGTGAAAC
22 003632 58 809013 55621006 EIF1AD NM_032325 mRNA ILMN 1680150
GTAGAACAGGCTCTGGC
Homo sapiens transmembrane CCACCCATATCTβGAGC ACCTAGGATGGGGTTTCTCTAATTGCTAATCACA
FLJ10846 protein 34 (TMEM34), mRNA AGTATTACGACCCGAG ACCCCACTGGGTCATG
40988365 98 38512 9849486 TMEM34 NM 018241 ILMN 1767320
Homo sapiens chromosome
CTAGCAGCACTGGGGACAGGAATGACTGGTCCC
MGC 16771 14 open reading frame 80 TTGAGGAGGTCGTGACA
52667854 152 75595 150 18512 C14ORF80 NM 173608 (C14orf80), mRNA
CATCATAAAAGCAAAGTC
RANBP7, FU14581, Homo sapiens importin 7 GTGCTCCAGTTGTGCCAAGTTCTTTCAATTTTGG AGCCAGCTGATATTTTGG MGC138673 (IPO7), mRNA AGGCCCAGCACCAGGG
TTCTCAAAAACTGC
12551845 8589226 8409309 IPO7 NM 006391 ILMN 1718001
Homo sapiens sal-like 3 GTGGTCTGTAGCCCAATAACTGGGGAACGAGTT
ZNF796 (Drosophila) (SALL3), mRNA ACAGACAAACATCACCG
16262679 37498096 374 51013 SALL3 NM 171999
Homo sapiens CCHC-type
ZCCHC22, CNBP1, RNF163, zinc finger, nucleic acid CAAGTAACATCTGTATCAGGCCCTACATAGAACA PROMM, ZNF9, DM2 binding protein (CNBP), TACAGTTGAGTGGGAG
2310 1895 3527 2893 3523856 CNBP NM 003418 mRNA
Homo sapiens RAD51 CTGGCTCCCGAGAACTT
CCC M i l l CTTGATACCACTCATCCACGTGTTCC
PIR51 associated protein 1 AAAAGAAGGGAGAAACC TGATTGTCCACATTTC (RAD51AP1), mRNA TCAACAAAGTCCAGCC
16081429 704 59344 70004346 RAD51AP1 NM_006479 ILMN 1684439
Homo sapiens dual specificity TGAGAATACTTGTCCCTG
TGCCCTCCCAGCCACTTCACATAGTCCTCGAGTC
MKP-5, MKP5 phosphatase 10 (DUSP10), GAGGATTATCACACCCC CCTGAAGAGAGAAGGC transcript variant 1 , mRNA AAATGCATAATCTCG
12 790279 104 77272 101 930954 DUSP10 NM 007207 ILMN 1757689
Homo sapiens protease, AGCAGAGGGCAGCTGAG
TGAGCTTTGGTGCTGACTACCCAGACGAGCTGA
TRY3, MTG, TRY4, PRSS4 serine, 3 (mesotrypsin) AGGCTGGGTGGCTGGG AGTGCCTGGATGCTCCG (PRSS3), mRNA CCTGGGAGACACACAGA
302 98096 9959684 981 77673 PRSS3 NM 002771 ILMN 1660907
Homo sapiens tRNA-yW
AGGACGGTGAGGATGAG synthesizing protein 3 AGGAAATTTGGGCAGGAAAGGGAACTCACAGTG
C1orf171, FLJ40918 CCCACGCTGGTGCAGAA homolog (S cerevisiae) TCGGAATGCCTGGAGCA GGAGCCTGTAGAAGCA
107 53928 156 78928 15668512 TYW3 NM 138467 (TYW3), mRNA ILMN 1725705
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens adaptor-related
GGCTCCAGCATCACTCC
DKFZp781K0743, AP105B, protein complex 2, beta 1 GCAAAACCTGTTGCCTCCACCACGGCTTCCCTCT TCTGCCACCTTGGGGTG CLAPB1, ADTB2, AP2-BETA subunit (AP2B1 ), transcript TGGCTCATTCCAAGCT TGGGGCTGGATTAAAA
72 45313 79997856 8009802 AP2B1 NM 001282 variant 2, mRNA ILMN 1792521
Homo sapiens ubiquitin A-52
CEP52, HUBCEP52, residue ribosomal protein GATGATCTGCCGCAAGTGCTATGCTCGCCTTCA MGC126881, MGC57125, fusion product 1 (UBA52), CCCTCGTGCTGTCAACT RPL40, MGC126879 transcript variant 1 , mRNA
32122414 45105215 45011 883 UBA52 NM 001033930
Homo sapiens Faπconi anemia, complementation TTGGTTAGGATGCCACCTCAAGAACTGTAACTGA
KIAA1794, FLJ10719 group I (FANCI), transcript GAGCTCAGAAGTGAGC
122 02549 44893097 44608093 FANCI NM 018193 variant 2, mRNA Homo sapiens X-ray repair complementing defective
CCTTACATCTGGCTGGAAAGCAGAGCCTCCTGG repair in Chinese hamster GAACACATCTGGCTGCA cells 3 (XRCC3), transcript
4095214 1825893 178 50177 XRCC3 NM 001100118 variant 3, mRNA
Homo sapiens Mdm2 p53
TCCTGTCCTAGTAAAATG binding protein homolog CCCCCCTTCCATCACATTGCAACAGATGTTGGGC hdm2, HDMX, MGC71221 GGCAAGTCCCTCTACCC (mouse) (MDM2), transcript CCTTCGTGAGAATTGG CCCACCCTCACCTGG variant MDM2, mRNA
12 538416 5806726 576 1309 MDM2 NM. .002392 ILMN 1688439
Homo sapiens enhancer of
GTCCTGGAGGTGTAGTG zestθ homolog 2 (Drosophila) CGGCATCGAAAGAGAAATGGAAATCCCTTGACAT
EZH1, ENX-1, MGC9169, KMT6 i GAGAGCAGTGGAAATGC
(EZH2), transcript variant 2, CTGCTACCTCCTCCCC ACCAAGGAGATGAGGG
3539872 14040594 139 12679 EZH2 NM. .152998 mRNA ILMN 1703172
Homo sapiens NFKB
GACTCACAGCAACTCTCCATTATAGCTTTCACAC
ITBA4, NRF repressing factor (NKRF), GGTTTGGATGTGCAGC
181 74345 30932263 30895593 NKRF NM. .017544 mRNA
Homo sapiens
GCTTGGCAGTATTTCAGCTGGCTGGAGGAATTG
AGM1, PAGM1 DKFZp434B187 phosphoglucomutase 3 GAGAAAGGCCCCAACCA
472 3351 6632976 662 5851 PGM3 NM 015599 (PGM3), mRNA
Homo sapiens fragile X mental AGCCAGCCTGGATCATT
TGCTATCCCTCCTCCCATCCTGTACCCCCCATTT
FMR1L2 retardation, autosomal TGTTGGCAGTACATATTG CTGGGGCCTCATCACT homolog 2 (FXR2), mRNA GCTGAAGTCAGTTTT
193 15594 18865476 1927 6809 FXR2 NM 004860 ILMN 1696051
Homo sapiens tripartite motif- CCCTTCAGGGACCAGCG
CATGCTTTACCTGTCCCACACCCATGCCAATGTG
TRIFIC, GENEY, FLJ23229 containing 46 (TRIM46), TCACCCTCCACCATGCAA CCAAGTCTCCCTTGGG mRNA GATCTCAACACCATG
10842679 23609763 23598929 TRIM46 NM 025058 ILMN 1703864
Homo sapiens
AGAGCCAGTCCTGTCGG
ADOMETDC, AMD, adenosylmethionine GGAGCTCTGTTTTGAGGACCAATGCTTAAGGTG CTGGGCCCTTGGACGGC DKFZp313L1234, FLJ26964 decarboxylase 1 (AMD1), GACTTTGTTCGTAAACA TGTCAGTTTTGCACAT
15158809 2342 356 2342 7476 AMD1 NM 001033059 transcript variant 2, mRNA ILMN 1784352
MGC75384, GW182, TNRC6, Homo sapiens trinucleotide
ACCTCCACGATTTCGCCACCAGGAACACAAACA FLJ22043, CAGH26, KIAA1460, repeat containing 6A GCTTCTAAAGAGGGGTC DKFZp666E117, GW1 (TNRC6A), mRNA
12 764698 7061104 66 103584 TNRC6A NM 014494
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequeπce_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens heterogeneous
CACCAAAGAGGTTCCCA
JKTBP2, JKTBP, IaAUFI, nuclear πbonucleoprotein D- CGCACGTTGCGGGCAGAGCGCAAGGCATACAC AGACAACTCGGAAGGGA HNRNP likθ (HNRPDL), transcript CAGAAAACGCTGTCCTGT AAAGGGACCCATCGAG variant 3, transcribed RNA
84048096 20274642 2006231 HNRPDL NR 003249 ILMN 1741604
Homo sapiens cell division
DKFZp686L20222, CDK1, cycle 2, G1 to S and G2 to M GGGCACTCCCAATAATGAAGTGTGGCCAGAAGT MGC111195, CDC28A (CDC2), transcript variant 1 , GGAATCTTTACAGGACT
441 38513 1677 906 1687 5101 CDC2 mRNA
Homo sapiens homeobox C4 CCAGTGGGCTCTGGCGC
TATTGCAAGGTGTGATGGTCTGGCTTGGGTGAA cp19, HOX3E, HOX3 (HOXC4), transcript variant 1, CTATGGCTCTGTGTGTG TTTCAGGGGAAATGAGG mRNA CTGCTTTTGACACAAA
11 244767 407 4018 42639758 HOXC4 NM 014620 ILMN 1788002
Homo sapiens TGATGGATCCTAGGGTT
CAGACACTGGACCACCAGAGAGTTTGAGGAGCT
MGC24132 methyltransferase like 6 CTTCATCACATGGGTGG AAGATCATGTAGAGAGT (METTL6), mRNA TATGGCAGGACTTCAG
74 116936 117 96011 118001785 METTL6 NM 152396 ILMN 1753862
Homo sapiens Kruppel-hkβ
ACCTCCAACCCCTGCTCCCACACAGTGACAGAC
TIEG, EGRA, TIEG1 factor 10 (KLF10), transcript CGGAAAGTGAAGAGTCA
56 55319 8463132 842727 KLF10 NM 005655 variant 1 , mRNA Homo sapiens asparagme-
GGGGGTGGGGGCAGGG hnked glycosylation 14 ACTACATTCACCGAATTCCAAGAAGCCGGGAGG
MGC 19780 AATTAAGTTGGTGGGCT homolog (S cerevisiae) TTCAGCAGTCCTGGCCC CGAAAATCCCATTCATA
128 36012 172 5476 172 32262 ALG14 NM 144988 (ALG14), mRNA ILMN 1680998
GACACTGGTCAGTATTTC
Homo sapiens forkhead box ACTGCCAGTAGATGACCAGTCACAAGTGAACCA
HTLF I I I l I I GGGGGGAACTA N2 (FOXN2), mRNA CTTCTCAGTTGCCAATC GGAGAGCAGGAGTAG
22625179 1373 3394 1408856 FOXN2 NM 002158 ILMN 1781870
Homo sapiens mitochondrial nbosomat protein S2Θ
FLJ22853, MRP-S35, MRP- CCAGAAGTGGATGGAGAGAAATACCAGAAAGGA (MRPS28), nuclear gene S28, HSPC007, MRPS35 ACCAGGGTCCGGTTGCG encoding mitochondrial protein, mRNA
732 5476 8862226 892 74347 MRPS28 NM 014018
Homo sapiens hypothetical GAGCTCTGAAGCTTTGA
CCAGGCTGCCCAGATTCAAATCCTGACTCCGCC protein MGC3207 (MGC3207), ATCATTCAGTGGTGGAG ACTTTTCCCACTGTATG transcript variant 1 , mRNA ATGGCCTTCTGGTAAC
62 034218 100 08929 10081013 MGC3207 NM 001031727 ILMN 1780141
Homo sapiens chromosome 6 open reading frame 48 TGCCATGTTGTCCAGGCTGGTCTCTACTCCTGG
G8, D6S57 (C6orf48), transcript variant 1 , GCTCAAGCAGTCCTCCT
28266582 8368672 82 88114 C6ORF48 NM 001040437 mRNA
FLJ14502, MGC141729, Homo sapiens chromosome CCAAAGAGGGAAGGGCC
GCGGTGAGACCCTGGCATCACGACAAGAATCCA MGC141728, TRAF4AF1, 15 open reading frame 23 AAAGC I I I I I CTACCTGT CTACTGATCACATGGAC HSD11 (C15orf23), mRNA GCATCCCAC I I I I I G
12372264 47943927 487 8476 C15ORF23 NM 033286 ILMN 1790988
Homo sapiens heat shock ATGCTGACACTGCCAAC hsp70, HS24/P52, RY, GCCCTATAATTTCAAAGCCCAAACCCAAAGTGGA 7OkDa protein 4 (HSPA4), CTCCAGTATCCTCACCCT MGC131852, APG-2, hsp70RY ACCTCCAAAAGAGGAA mRNA CGCAGACGATATCTC
306 19763 41228513 40648096 HSPA4 NM 002154 ILMN 1708619
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS * 6 GFs Raw Raw Common Gβnbank Description Probe Id
Homo sapiens minichromosome maintenance
ACCACAGCAAAGGTTTCATTCAGGAGATTCTTCC
PRO2249, CNA43, MGC126776 complex component 10 ATCTGGGCAACCTGGT (MCM10), transcript variant 2,
20616997 122 33928 12443512 MCM10 NM 018518 mRNA
Homo sapiens RhO GTPase
GAP (1-12), KIAA0013, activating protein 11A TTTTCTATCAACAATTGGGAAATGCTTATACATGT MGC70740 (ARHGAP11A)1 transcript AAATATGAAAATGTT
76 33147 9485596 95 18513 ARHGAP11A NM 199357 variant 2, mRNA
Homo sapiens RCD1 required for cell differentiationi CTTGGGTAAGATGGTCCTGCAGCTATCCAAAGA
RCD1. CNOT9, RCD1 + homolog (S pombe) GCCTTCTGCCCGTCTGC (RQCD1 ), mRNA
441 6768 8799351 886 3476 RQCD1 NM 005444
LIN-7C, MALS-3, FLJ11215, Homo sapiens lιπ-7 homolog C TGCTAGTAGTGTTTCTTCAAAGGTTATTCCAGGT VELI3, LIN-7-C (C elegans) (LIN7C), mRNA ATGGTTAAGTAGTGAG
994518 17081845 16395596 LIN7C NM 018362
Homo sapiens calreticulin CCCTCCAACCTGGGGGGCAGTGGTGTGGAGAA
FLJ26680, cC1qR, RO, SSA NM .^343
1738856 2057906 20620977 CALR (CALR), mRNA GCCACAGGCCTGAGATTT
PREDICTED Homo sapiens CCAGGAGCCCGAGAAGA similar to H3 h.stone, family 2 ^000^^00^ ATGGCCCGTACTAAGCAGACTGCCCGCAAGTCG isoform 2 (LOC6536O4), ACCACTGAGAAGCTGC ACCGGCGGCAAGGCCCC
16963947 136 51012 13808928 LOC653604 XM 497711 mRNA ILMN 1688877
Homo sapiens chromosome GCCTTTGCCTCGCCGAG
GGCGTGGACTCGCTACTCCGTTCTTCACAGCTG
HSPC154 18 open reading frame 55 GGAGGTCTTGCTGGAGC CCTTCCAGAATGTGTTC (C18orf55), mRNA GGCCGTGCTGGCTGGA
8476476 1748281 1721 4559 C18ORF55 NM 014177 ILMN 1717780
Homo sapiens chaperonin
CCGAGGAAGCTGGGCG containing TCP1, subunit 6A GTCCTAATCATTGGAGAGCTGCTGAAACAGGCA
DKFZp779B0634 GTACCTGGAGACCTACA (zeta 1 ) pseudogene 1 GATCTCTACATTTCTGA AGGCCTATGAGCAGAAA (CCT6AP1 ) on chromosome 7
56 54869 132 51012 128 14345 CCT6AP1 NR 003110 ILMN 1726562
Homo sapiens Iβucyl/cystmyl GGACATGCCAACTCGGA
TTCTACCCTAAGAGCCGCCATCACTTCAGGCCG
P-LAP, PLAP, IRAP, CAP aminopeptidase (LNPEP), GAAAGCTCCCCTGCGGA CTGGTTTGTCAGCCATC transcript variant 2, mRNA AAACTTCAGAGGCTGC
71 97715 17947263 17462262 LNPEP NM 175920 ILMN 1659378
Homo sapiens cytoplasmic
TCGGGGACCTCCAAAGA
MGC34136, CEBP, CPE-BP1, polyadenylation element GCCCCTCCTAGGGAAGCTGTGTGCCAAAGAACC CTAAACTGACAAGCCTTC MGC60106, CPEB, FLJ13203 binding protein 1 (CPEB1), AGTGTCATAACCCCTCC AAGGAGCCCAGGGGT
7 0834045 11033098 101 03097 CPEB1 NM 001079534 transcript variant 4, mRNA ILMN 1677532
Homo sapiens activating
RNAH, ASC1p200, signal cointegrator 1 complex CTAACTCTGCCGCATAAACTATAAATCTGTAAGG dJ121G134, HELIC1, subunit 3 (ASCC3), transcript TGGTACACAGCGTGTC DJ467N11 1, MGC26074 variant 1 , mRNA
20372678 23529346 23028928 ASCC3 NM 006828
CTCACCCGCCATTTTGTA
Homo sapiens arginyl-tRNA TGTGGCGTATGCTGCTATGTGAAGCAGTAGCTG
ArgRS, DALRD1, MGC8641 GGTCTGAGGGTGCTTGG synthetase (RARS), mRNA CTGTCATGGCCAAGGGG ACATACTCTTCGAGC
2167 7642 3435281 33888975 RARS NM 002887 ILMN 1657440
pOS + no GFs
Synonyms Genban(( Probβ Sequβπce Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Description Probe Id
Homo sapiens v-myb
AGCAACATGCTTGGTAAT myeloblasts "nd oncogene πGGCATCTGTTAAGGTA GTGTTTGCAACTGGGGAGACAGAAACTGTGGTT c-myb_CDS, Cmyb, c-myb, efg homolog (avian) (MYB), GATAGCCAGTCACTGCC
GGAGAGTGGTGAAC
8083271 14943094 137 69762 MYB NM 005375 mRNA ILMN 1788778
Homo sapiens quaking GGAAGGGCAGGATGTAC homolog, KH domain RNA GTTCGAAGGCACGATATGCGTGTCCATCCTTAC
DKFZp586IO923, Hqk, QK3, QK cccTGAAACCGGATGCT binding (mouse) (QKI)1 CAAAGGATTGTGACCGC
GAGTACCCTGAATGGC
12996011 446 98926 43603094 QKI NM 006775 transcript variant 1 , mRNA ILMN 1658486
Homo sapiens splicing factor
SF3a66, SAP62, PRPF11 , TTTTGTACTGCCCCCCGCTCATTAAACAGCCTCC
3a, subunit 2, 66kDa (SF3A2), PRP11 cccAGCCCTGAGTGCA
1999 3477 23544893 23497227 SF3A2 NM 007165 mRNA
Homo sapiens chromosome
CCACACACCCAGGAGAAGGTGGATAAGTGGGCT
MGC13170 19 open reading frame 48
ACCAAGGGCTTCCTGCA
17842679 511 58093 497 9018 C19ORF48 NM 199250 (C19orf48), mRNA
- „,, GTGCGACCTCGATCTGT
CCAGGTTGGCCACAGACAGCTTAGAAGCCATTC
SPD, BDE, HOX4I, BDSD CCCAAGCATTCATGTTCC
(HOXD13), mRNA CT A TGTCTCCAAAAGGC
CTCCACCCCAAGGCCTTGGTTAAGGT GGT T 1757336
69454895 13561429 132 41846 HOXD13 NM 000523
Homo sapiens family with
TTGGCAAAGGTCAGGCA
FLJ22155, FLJ20152, sequence similarity 134, GCCTCATGACTGTGTTTGATGTCCTTTATTGATA GGGGCTGGGAAAGCATT FLJ22179 member B (FAMI 34B), CAAAGTGAGCCTGTGC AGGTGGACCAGGCATG
19312956 12908928 120 33511 FAM134B NM 001034850 transcript variant 1 , mRNA ILMN 1754132
Homo sapiens ATPase, class GCTGTGCCCTGCGTGTC
ATCTGAGCTGTAGAAGGGCATCTGACTCATTATC
ATPIQ, ATPIG Vl, type 11C (ATP11C), GCCCAGGCAGGTGTTTG CGCCAGACCTTCAGTC transcript variant 1 , mRNA TΠTTGAGCGCAGATT
1630287 96785126 91 89351 ATP11C NM 173694 ILMN 1684192
Homo sapiens TTK protein CTGGGCCAACTTGTTGGTCTGAATTCTCCTAACT
PYT, MPS1L1, FU38280, ESK
161 82689 8064143 784 256 TTK NM 003318 kinase (TTK), mRNA CCATTTTGAAAGCTGC Homo sapiens punne-rich
MGC126786, MGC126784, GCAGAGTCCAGACGGGCTGTTGATCTCACTGCC element binding protein B PURBETA TGTAGGTTGAAGCTCAG
1693 3893 6151 7144 6040 7812 PURB NM 033224 (PURB), mRNA
CGCAGGGAGACAGTTCA
Homo sapiens KIAA0586 GAGTCTCAGCACAATGCAGGAGGACATGGAGTC
Talpιd3 GTCACTGCAATCTTCATG (KIAA0586), mRNA TTCGGGGGCAGATACCT cccATCAGTTTCTTG
7935768 162 73096 16038928 KIAA0586 NM 014749 ILMN 1659452
Homo sapiens MKI67 (FHA
GGAGTGGTGTGTACCCC domain) interacting nucleolar GTCCATCTACATGGTTTGTCGGGGACATTTAACT
NIFK, Nopp34 TAAATCCTCCCACCCCAG phosphoprotein (MKI67IP), CATGGAGGTGCTTTAG CACTGCCCATCTGTA
1226231 14030143 13937268 MKI67IP NM_032390 mRNA ILMN 1736936
Homo sapiens arsenate CAGAGGAAACAGAAGAT
TCCCCCGTTCCTCAGTCCTGTATCATCCATACTT
ASR2, MGC126427 resistance protein 2 (ARS2), AACGCTCAAGTGGCTGA GTACTACCTTGTCCTA transcript variant 1 , mRNA ACAAATGGCCAGTGGA
2181 9226 30259143 30393892 ARS2 NM 015908 ILMN 1753658
Homo sapiens AT rich
BCAA, RBP1L1, MGC163290, interactive domain 4B (RBP1- GAGTGCTATCCACCAGGCATGAAAGTCCAAGTG BRCAA1, SAP180, RBBP1L1, like) (ARID4B), transcript CGGTATGGACGAGGGAA DKFZp313M2420
151 73096 29397263 288 75595 ARID4B NM 016374 variant 1 , mRNA
Homo sapiens ets variant TGCCTTCCTTGACCATCT
GGGCATAGGACAGCGGCATCACGGTTGCATTCC
ERM gene 5 (ets-related molecule) ACCTTGAACTAACCCACT CATTGGACTCATGCACC (ETV5), mRNA CCCAGCTCCCAGCC
85608093 10233476 1015 5518 ETV5 NM 004454 ILMN 1794213
pOS + no GFs
Synonyms Qenbank Description Probβ_Sequβncβ Probe_Sequence_l Raw XS pOS + β GFs Raw Raw Common Probe Id
Homo sapiens protein GCAGCATAGTTGGGAGC
CATGTCACTACTGGGGAGGTGTTCCTGCTCTAG
MGC1671, ASE1, MGC3669 regulator of cytokinesis 1 CTTCCACGATGAGGCGC
12500226 3548356 34984058 PRC1 NM 199413 mRNA tran Vaπant CCTGTGAGCCCCATG ILMN 1698463
Homo sapiens cell division cycle 25 homolog C (S GCCGCTGTCTGCGTGAAGAGGACAGGTCTCTGA
CDC25 pombe) (CDC25C), transcript ACCAGTATCCTGCATTG
23841621 10060186 99 15615 CDC25C NM_001790 variant 1 , mRNA
Homo sapiens nucleoporin GCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAG
NUP84
323.2101 1128 1476 11094226 NUP107 NM 020401 107kDa (NUP107), mRNA GGACTTGACCCATTAG
Homo sapiens bromodomain
TTTCGTACCTTCCCACTG and PHD finger containing, 1 TATTCTCATTTGTAACTGCGTTTCCGGGTCGCGC
BR140 GCCTCAAGTGAGCCAAG (BRPF1 ), transcript variant 2, CAGAGTCATTTGGTAC AAACACTGCCTGCCC mRNA
998 3726 7531 0977 7367 3975 BRPF1 NM 004634 ILMN 1727458
Homo sapiens thymopoietin
MGC61508, PRO0868, CMD1T, CCATGGGAAATGCCACTGTAGGTCGTCGATACC
(TMPO), transcript variant 1 , TP, LAP2 TCTGGCTGAAGGATTGC
11273512 467 56012 462 85596 TMPO NM 003276 mRNA
Homo sapiens stress-induced-
HOP, STML, IEF-SSP-3521, phosphoprotein 1 GAAGACACAGAGACTCGTACCTGCGCTGTTTGT P60 (Hsp70/Hsp90-organιzιng GCCGCCGCTGCCTCTGG
11470227 1608281 1601 781 STIP1 NM 006819 protein) (STIP1), mRNA
Homo sapiens sed family AATGTGTAGGAAAAGCCT
KIAA0917, C14orf163, SLY1, CCATTCCAAGAGGCCATTGTTTTTGTGGTGGGA domain containing 1 (SCFD1), TCTGGCCACCCAGAGAG RA410, STXBP1L2 GGAGGCAACTACATTGA transcript variant 1 , mRNA CCGGAGCCCTGCTTG
17437976 2611 331 2611 931 SCFD1 NM 016106 ILMN 1812080
CTTGAGTGTCTTGCTGA
Homo sapiens nucleoportn CACTGATTTGACATAGTCTGGCTGTACCCAGGAA
HNUP153, N153 GGGTTACTGTATCTAGCA 153kDa (NUP153), mRNA TGGAGCCTGCACGGTG
GGTGATGGAGCTTGG
261 34763 17804309 17332686 NUP153 NM 005124 ILMN 1750412
Homo sapiens hyaluronan-
RHAMM, MGC119495, IHABP, mediated motility receptor TTTCTTCAGAGTTTGTCATATACTGCTTGTCATCT MGC119494, CD168 (RHAMM) (HMMR), transcript GCATGTCTACTCAGC
17769763 10359476 9938143 HMMR NM 012484 variant 1 , mRNA
MGC126616, RECQL2, BS, CCCTCAATATCACCTCCC
Homo sapiens Bloom TGCCAGCCTCCCAAAGGTCTAAGAGGAGAAAAA RECQ2, MGC131620, TTCAGATGCACTCCCTGA syndrome (BLM), mRNA CTGCTTCCAGTGGTTCC RECQL3, MGC131618 GACTCCTGAGCCAG
24 850307 19565594 18678513 BLM NM 000057 ILMN 1743219
Homo sapiens Sιn3A-
CCACCCCATTCGGTTCTTCTGCCTGACCTTCAAA
FLJ12761 associated protein, 13OkDa TGCCCATGTTGGCCTT
24883928 379 18927 378 13095 SAP130 NM 024545 (SAP130), mRNA
Homo sapiens casein kinase AGAAGGAATGGCTGGTC
GCAGGCCCAAACccccACAGGCAAGCAAACTGA
HLCDGP1, PRO2975, CK1 1, alpha 1 (CSNK1A1), CAGAGGCTTTTGTCCACT
CAAAACCAAGAGTAACA transcript variant 2, mRNA CCCTCTCACTGGAAG
16064345 4905518 48081012 CSNK1A1 NM_001892 ILMN 1654612
Homo sapiens chromosome 1 AGCCTTAGTCCAGGGGT
TCTGGATGTGACTCTGTTACCCTTTTCCCACAAG
FLJ14264, MGC2603 open reading frame 135 GTGGCTCTGTCCGGGTG ATAGGAGGGAATCCCC (C1orf135), mRNA CAGTATGCAGTCATGT
70993546 24442262 237 16013 C1ORF135 NM 024037 ILMN 1783448
Homo sapiens extra spindle
SEPARIN1 GCTGGCATCGTGCTCAAGTACATCATGGCTGGT pole bodies homolog 1 (S
FLJ46492 TGCCCCTTGTTTCTGGG
91 381386 42291846 411 98096 ESPL1 NM 012291 cerevisiae) (ESPL1), mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS ♦ 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sap,ens phosphoπbosyl
GGCAGCATGGAGGAGGCAAGACCTGTGGGTCA
ATASE, GPAT, PRAT pyrophosphate CCGCACAGAGCGGCCTG aminotransferase (PPAT), TCTTTATCAGAGGTCC ATTTTGAACTGGCCTTAC mRNA
167 52261 4558476 443 16846 PPAT NM 002703 ILMN 1702706
Homo sapiens ankyrin repeat CCCATTCCAGAGAGGGT
PP12899, FLJ00040, VARP, GAGGCCAGGCTGAAATGTCATATCTGAAGGAAG domain 27 (VPS9 domain) CCTGCCCCATACCCAGA DKFZP434L0718 AAAGCAGCAGCTGGACA (ANKRD27), mRNA AGGAAAGAATGCTGCT
85 30209 11443512 10929346 ANKRD27 NM 032139 ILMN 1712936
RP11-13G14, P100, TIP110, Homo sapiens squamous cell
CCTCTTGTGGGGGTGGGTCTGAGGGAAGTCAGC KIAA0156, p110(nrb), DSAP1, carcinoma antigen recognized TATAAAACATTTGCTGG MGC138188 by T cells 3 (SART3), mRNA
39615562 75048676 6804352 SART3 NM 014706
Homo sapiens solute carrier
ZnT-5, MGC5499, ZTL1, GGCAGCACTTATGCTCT family 30 (zinc transporter), CATGCAGTTGCTGGGTGTATTATTTCACTCTTGT FLJ12496, ZNTL1, FU12756, GTGACAGTATTGTGTGTC member 5 (SLC30A5), GG I I I I I I GGCCTCAC ZNT5 ATAGTTGAGCAGTAG transcript variant 1 , mRNA
5259226 697 71423 67308093 SLC30A5 NM_022902 ILMN 1673478
Homo sapiens MAX-like
TGAAGGGTGAAAGGGCACCTTGTGCCTAGACTA
MXD7, MAD7, TCFL4 protein X (MLX), transcript GGGCTGCCTGGTCAGTC
12321847 191 62679 18003928 MLX NM 198204 variant 2, mRNA
Homo sapiens ceπtrosomal GCTTTCTGGGTCGGGTG
FLJ21979, FU13615, GCTAACAAGGACCAAAGTGGAGCTGAAAGCACC protein 29OkDa (CEP290), TGGTGGTTCTTGCCTATA KIAA0373, 3H11Ag, 3H11 ATACCTGATGCTGATCA mRNA GTCCCAGTGCTTTGG
47 54752 7673982 7003239 CEP290 NM 025114 ILMN 1688281
Homo sapiens low density lipoprotein receptor-related GGTGGGCCTGTGGTGAT
GAGACGTTTCCAGATCAGCCCAAGTTTACTATAG
HSZ75190, APOER2, MCI1 protein 8, apolipoprotein e GGTTTGCATCCTTCCTCC
AGACTGGCCCAGGCAC receptor (LRP8), transcript CTTGTCCCAATAAAG variant 3, mRNA
161 24762 802 0476 651 1726 LRP8 NM 017522 ILMN 1743747
Homo sapiens nicotinamide
C1orf15, PNAT2, KIAA0479, nucleotide adenylyltransferase GGATCCACATGGTCTTGAGGGTTGGCATGAGGA PNAT-2, MGC2756 2 (NMNAT2), transcript variant GGGGGAAGCTTTTTTGA 1, mRNA
71 06278 129 74345 12328929 NMNAT2 NM 015039
Homo sapiens RAN, member
GCTCCACCTTCATATTGGCTAGGTAGGGTCACCT
TC4, Gsp1, ARA24 RAS oncogene family (RAN), AGGGAAGCACTTGCTC
57996423 10300726 964 881 RAN NM 006325 mRNA
AGGGGGCGGGCCTGAG
Homo sapiens PBX/knotted 1 GGCGGCGGTTTCCCGAA TGTCCAGAGGGGGTTCTGCCCCTTGTGAAGGCC
PREP1, pkonx1c homeobox i (PKNOX1), CGGAGCGGGGCCTGCT CATTCCTGGCACTTAGA mRNA
46 14446 7577009 71 13081 PKNOX1 NM 004571 ILMN 1651436
Homo sapiens quaking homolog, KH domain RNA TGAACCTAGTGGTGTATTAGGTGCGGTGGCTAC
DKFZp586IO923, Hqk, QK3, QK binding (mouse) (QKI), TAAAGTTCGAAGGCACG
19669762 231 86429 22764761 QKI NM 006775 transcript variant 1 , mRNA
Homo sapiens cardiotrophin- GGCCAAGGTAAGAACTG
CCAGTATTACGGTGCCTCTTCTCTGCCCCCTTTC
CISS2, NNT1, CLC, BSF3, NR6 like cytokine factor 1 (CLCF1), AGAAGGGAGGCATGAGG CCAGGGTATCTGTGGG mRNA CGTGAGGCTGGAAGAT
3223601 1652 281 1387 606 CLCF1 NM_013246 ILMN 1813307
pOS + no GFs
Synonyms Probe_Sequβnce Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe Id
Homo sapiens diaphanous
FLJ34705, DRF3, homolog 3 (Drosophila) GACACTCATACGTCTACTGGGAGGATCAAGGCA
DKFZP434C0931, dιap3, (DIAPH3), transcript variant 1 GCTGAGAAGAAGGAAGC
DKFZp686A13178
15027678 374 76846 33432263 DIAPH3 NM 001042517 mRNA
Homo sapiens abhydrolase TCTGACTTCATATCTGTG
CCAGGCAGAGACTACCTTTGTGACCAGCTCCCA
FU11342 domain containing 10 GGATCCACACAATGGGG
GTAAAAACCCCAGGCAC (ABHD10), mRNA AGGTACTGGCCTTGG
11389345 275 18097 25324762 ABHD10 NM 018394 ILMN 1696318
Homo sapiens THO complex 2 TGACCTTTCTCTGGCCC
GAGAAGATGGATAAAATCTCCTCCGGTGGCAAA
CXorf3, dJ506G2 1, THO2 (THOC2), transcript variant 2, CCAGCTCTAGTGTTTGA
AAGGAGTCCAGGCATGA mRNA GTAAAGGAGACTGAGG
21673929 301 65594 292 0476 THOC2 NM 020449 ILMN 1688479
Homo sapiens ring finger CCCAGCCCTGGCTGGGCCCAGCGCCTGTGTTCT
KIAA1100 protein 44 (RNF44), mRNA GTGTTAGAAAGGTTTTA
40681957 377 0476 2946101 RNF44 NM 014901
FLJ13288, ZC3HDC2,
Homo sapiens zinc finger
MGC48898, DKFZp686F2052, GGCGGCCCCGTCTCTGT CCCH-type, antiviral 1 CCAACATTTGTGCCTCAGTGGTATGTGCAGCAG
FLB6421 , ZC3H2, ZAP, TTTCATTCCCTGAGATGT (ZC3HAV1), transcript variant ATGAAGAGAGGGCCAGA
DKFZp686H1869, GGTGCTTTCTCTCCT 1 , mRNA
DKFZP686O19171 NM 0201 19
67 59301 12467262 112 96011 ZC3HAV1 ILMN 1780406
Homo sapiens polymerase CTGAAGAAACAACGCAG
DKFZp781A0112, PRO0327, CAGTCCCTTAGTGCCTCTTTCTGTTTGTGGCATG (DNA directed), thθta (POLQ), TGTCACGCAAGCCACTC POLH GTGAGAAAACCCATGC mRNA AGACAAGCCCAGGGGT
58 873806 4658976 35544763 POLQ NM 199420 ILMN 1737705
COX7AL1. MGC118950, Homo sapiens cytochrome c
GGAGGCCAGTGTAACGT
MGC118952, MGC126877, oxidase subunit Vila CGGAATCTGCTGGCTCTTCGTCAGATTGGGCAG TACATGACTCGTTGAGAA
COX7AL, MGC118951, polypeptide 2 (liver) AGGACGATAAGCACTGC AGTTGAGGAATTTCC
9621 147 11266 139 11040273 COX7A2 MGC126875, COXVIIa-L NM_001865 (COX7A2), mRNA ILMN 1746664
MGC18000, CAP-H2,
Homo sapiens non-SMC
MGC8640, MGC5305, hCAP- CAGGATCGGCGGAGTTC condensin Il complex, subunit AGGAGCAGCCAATGGAAGTTTCCGTGTGCAGGA
H2, MGC2455, 384D8-2, GAAAACGAACTTCCCAC H2 (NCAPH2), transcript GCCCTGTCCCAGCACTC
MGC15858, 384D8_6, GTTTGCTATGTTGCCC variant 2, mRNA
32 577946 91 414314 79532104 NCAPH2 MGC4133 NM_152299 ILMN 1723230
Homo sapiens structural
SMC2L1, hCAP-E, FLJ10093, maintenance of chromosomes GCAGCCTTGGATCTTTCTCATACCCAAAACATTG CAPE, CAP-E 2 (SMC2), transcript variant 1, GACAGATGCTGCGTAC
83 173096 39444763 32241428 SMC2 NM 001042550 mRNA
Homo sapiens nuclear receptor subfamily 3, group C, CATGACCACTGGGATCC
CCTGGTCCACCCAGGATTAGTGACCAGGTTTTC
GCCR, GRL, GCR, GR member 1 (glucocorticoid AGCCAGCGGGGGATTTC AGGAAAGGATTTGCTTC receptor) (NR3C1), transcript TTTTCCTGATGGACTG variant 6, mRNA
79006966 10565186 101 706085 NR3C1 NM 001020825 ILMN 1759504
Homo sapiens H1 histone CCTGGGCTACTGCTGCC
TGCTTTAGG I I I I I GAAACAGCCCCGGCGACGC
MGC8350, H1X, MGC15959 family, member X (HIFX), CTCTGGCCCAGCCCTGC CTCTATTGGCTCTCGGC mRNA TATCTCCCTCCGTCCT
37273096 62668933 581 15594 H1FX NM 006026 ILMN 1710762
Homo sapiens eukaryotic ATGAAAGAGGACGCGAA
EIF-2B, EIF2Bepsιlon, CACH, translation initiation factor 2B, GAGGAGCTAAGCAGGCCCGGCAGTTGGAGGAA AGGGAAGAGCGAGGAG LVWM, CLE subunit 5 epsilon, 82kDa GGCCAGAGGAACAGCTTT
GAGCTGGCCGAGTGCTT
191 88095 24494345 243 31012 EIF2B5 NM 003907 (EIF2B5), mRNA ILMN 1693428
pOS + no GFs
Synonyms Probe_Sequence_l Raw XS pOS * 6 GFs Raw Raw Common Genbank Description Probe.Sequence
Homo sapiens ubiquitin specific peptidase 7 (herpes AGGTTAGTGGATCGGGGGTCCCTGGCTCAAGGT
HAUSP, TEF1 virus-associated) (USP7), CTCTGGGCTGTCCCTAG
196 98096 251 31012 242 53928 USP7 NM 003470 mRNA
Homo sapiens cytokine
CREME9, FRWS, CYTOR4, GCACGTGTGTATCCAATCTGCCTGTGACATGCAT receptor-like factor 3 (CRLF3), MGC20661 TTTACTCTTTGCAGAG
18478928 332 7851 3060476 CRLF3 NM 015986 mRNA
Homo sapiens chromosome
CTCCTGGGACTCTCCAA 19 open reading frame 29 CCGACGGGAACATCTCCAACAGAAGCAAAACGG cactin, NY-REN-24 CCAGGCTGAACATCAAA (C19orf29), transcript variant AAAGTGCCTCCCGGACC ACCTCCTCTTTGTGCT
9059766 107 547615 107 33931 C19ORF29 NM 001080543 1, mRNA ILMN 1663913 Homo sapiens monocyte to
GGCTTGCCTTTAGATCGGGTGCTGATATTGCCT
PAQR11. MMA macrophage differentiation- GTTTCCTAGTAATGGGC
131 81012 302 80594 27593927 MMD NM 012329 associated (MMO), mRNA
MGC131698, PCL3, Homo sapiens PHD finger GCGCTGCTGTGGCTAAC
AGTCCCTGCCTCTCCTGCCTCCTCCAGTGGGGC MGC23929, MGC149713, protein 19 (PHF19), transcript ACCACTGTGTATGTTTCA AGACCAGAGACTCCCAT MGC149712 variant 2, mRNA TCATTGCTCTGAAGG
69019844 2753393 22328513 PHF19 NM 001009936 ILMN 1784083
Homo sapiens transcription factor 12 (HTF4, helix-loop-
CAGAAGTTGTTGCTTATGATGTGTGAGTGAACAT
HEB, HsT17266, HTF4 helix transcription factors 4) ATGCCACTGCCTGGCC (TCF12), transcript variant 2,
66982263 1292 0476 1192 5725 TCF12 NM 207037 mRNA
Homo sapiens chromosome CTGGGGAGACAAAAATA
CCAAGGACCAAATCCTGGAGTTCTCCCAACTTTA
MGC4832, RAMA1 13 open reading frame 3 ACTGATCCGTTGGGTGT GAGGATGGAAAGGGGC (C13orf3), mRNA ATACCATGTGCCAAGC
40781334 2767393 214 5893 C13ORF3 ILMN 1659495
Homo sapiens aspartyl-tRNA synthetase 2, mitochondrial
FU10514, ASPRS, RP3- ACATACTTGCCCTGGCTACCTCACCGGGCTGTT (DARS2), nuclear gene 383J4 2, ASPRS LBSL ATTGCTGGAATCAGAGG encoding mitochondrial protein, mRNA
79977234 188 11844 16591428 DARS2 NM_018122
Homo sapiens zinc finger GCTTACACTCCATCCAAACCTAACTCTGCCAACC
FLJ21941 MGC120638 protein 614 (ZNF614), mRNA ACTTTTCTCCTATCAG
14240594 17688928 171 15594 ZNF614 NM_025040
Homo sapiens RNA binding
S164, MGC105088, RNPC7, ACACACCTGGAGAGGACATTTGAAAACACTGTTC motif protein 25 (RBM25), MGC117168, RED120 TTACCCTCGAACCCTG
537 1101 70698096 682 1309 RBM25 NM_021239 mRNA
Homo sapiens nucleopoπn
MGC13407 CTGTGTΓTAATGATTATTGTCCATTGAGCCTGTA
62024756 11154309 1026 9976 NUP54 NM_017426 54kDa (NUP54), mRNA CTCTGCTTTCCATACC
Homo sapiens proteasome
AGGCCATTTAATAAAAAG
(prosome, macropain) 26S GAAAGCCAACCTACAATACTACGCCTAGGGCAC MGC8487, TBP1 GGCACAAAGCCTGTCAG subunit, ATPase, 3 (PSMC3), ACAGGCCAGCCCCAGTC AGTTTTCAACGGTGC
1503 3142 21043726 2017 106 PSMC3 NM_002804 mRNA ILMN 1785821
Homo sapiens Zwilch,
FLJ10036, FLJ16343, kinetochore associated, GAGTCCAGGAGTTTGAG
AGGCACTGGACATCCTCACGTGGAGTTCACAGG KNTC1AP, MGC111034, homolog (Drosophila) ATGCGCCTGGGCAACAT CTCATCAGTGAATTCTG hZwilch (ZWILCH), transcript variant 2, AGAAACCTGTGTCTAC
454 72678 15824559 1331 8851 ZWILCH NR 003105 transcribed RNA ILMN 1668713
pOS + no GFs
Synonyms Probθ_Sequence ription Probe SequenceJ Raw XS pOS + 6 GFs Raw Raw Common Genbank Desc Probe Id
Homo sapiens PAX interacting
TNRC2, PACIP1, CAGF29, ACAGTCAGTGATGGTGG (with transcription-activation CCTTCACATGCTCTTGTTTTCCAGCTGCTTTCCT PAXIP1L, CAGF28, PTIP, AGATGGAAGCAGCAGTG domain) protein 1 (PAXIP1), GGGGGATCAGACTGTG FLJ41049 AGGAAATTAGGATTCC mRNA
106 33928 17305179 161 53513 PAXIP1 NM 007349 ILMN 1699317
Homo sapiens zinc finger, matrin type 5 (ZMAT5), ATGCTccTGAGCTCcccGAGGGCCATCTGGAGG ACTGGCTGGAGAAGAGA
105026794 12958511 12642678 ZMAT5 NM 019103 transcript variant 1 , mRNA
Homo sapiens flap structure-
GAGAAGATGGGCAGAAAGCTGGAGCCCCTGGA
RAD2, FEN-1. MF1 specific endonuclease 1 GTTGGCTGTGTCTGTGTT (FEN1), mRNA
6560393 33828809 28647976 FEN1 NM 004111
Homo saptens exosome AACTGGGGGTGGTTCTA hMtr3p, MTR3, p11, EAP4, TGTGTGTTTTCTGCGGCCCTGGATAATGCTGTAG component 6 (EXOSC6), GGGGAACAGGGGGCGG Mtr3p CATTCAGGGTCGATTG mRNA GGGAGCTGTTTCTATTT
51920593 791 2101 757 381 EXOSC6 NM 058219 ILMN 1670508
Homo sap,ens RRS1 ribosome CAGAGCCTGAGATGGAC biogenesis regulator homolog GTAAGGAAGAGAACTGG CCTGGCCGCTGCCTTCATTGAGTTTAAAGGGAC
KIAA0112 (SRCerev,s,ae) (RRS1), AGTGGCAGGGTCCCAG AGGATTGCCCTTCCGTC
27222263 727 42676 654 5768 RRS1 NM_015169 ILMN 1664243
OR17-24, OR17-13, OLFRA06,
Homo sapiens olfactory TGTCGCTGAGCCGGACG OLFRA05, OR24, OR17-16, CTTCGGACAAGGACAAGGGCATTGGCATCCTCA receptor, family 3, subfamily A, ACTGCCACCATCGCGCC OR25, OR3A4P, OR3A5P, ACACTGTCATCAGCCCC member 4 (OR3A4), mRNA CATTCTT AGCGTGCCA
8348111 98 13928 9648096 OR3A4 OR17-25 NM_001005334 ILMN 1737435
Homo sapiens S100 calcium
DT1P1A7, MGC17528, S100F, GCTGTCTGGGGACCCTAAGAGTTTTCTCACCTGT binding protein A16 AAG13 TCAGTCTCATCTAACC
5152 1973 6490298 63488726 S100A16 NM 080388 (S100A16), mRNA
TCCGTGAATCCCTTAGA
Homo sapiens kiπesin family CTGGGGTTGTCCTGGCTCTGGGGAGAGAGACG
KNSL6, MCAK GGTCTGTGAATTGTAGG member 2C (KIF2C), mRNA GAGCCTTTAGTACAGCTA TTAAGAACCCCTGCCC
14623096 55032263 48554346 KIF2C NM 006845 ILMN 1762003
Homo sapiens SPC24, NDC80
CGCTGGTTTTGTCACATT kinetochore complex TAGAAGGCAGAGGCCGGCAGATCACTTGAGCCC
SPBC24, FLJ90806 CAGCATTATCCAGGCATC component, homolog (S AGGAGTTGGAGACCAGA AGGCAACATCTGTC cerevisiae) (SPC24), mRNA
133 14359 4937726 4297226 SPC24 NM 182513 ILMN 1725105
Homo sapiens Zwilch,
FLJ10036, FU16343, kinetochore associated,
GCATGTGACTTAGCAAGGGCTCTGAAATGACAAA KNTC1AP, MGC111034, homolog (Drosophila) GAGAACGAGCACCACA hZwilch (ZWILCH), transcript variant 1,
65 33041 287 8393 245 38928 ZWILCH NM 017975 mRNA
FLJ21597, PAM, FLJ13826, GGACATGCATGGGGCTC
Homo sapiens MYC binding GAGGTGTTTGCATGTGGCCATTACCGTCATTGG
FLJ10106, FLJ21646, TGGGAAGACTCCTAGAT protein 2 (MYCBP2), mRNA CCTGTGAAGCATTGGAC
DKFZp686M08244, KIAA0916 NM 015057 AAACACTTTAAGAGGC
43088928 48381427 478 3518 MYCBP2 ILMN 1757546
AOA, FLJ20157, AXA1, EAOH, Homo sapiens aprataxin
GATGGTGTGGGGGGTTGGAGTTTTCTTCTAATA
MGC1072, EOAHA, AOA1, FHA (APTX), transcript variant 5, CCGAGGGTTCCTGGCTG
252 13928 317 76013 311 75595 APTX HIT NM_175071 mRNA
Homo sapiens transcription AGGGATCTCTCCCATAG
CAGCCATCTCTGCAGTTCTCTCAGTGCAGGCAG
HuF2 termination factor, RNA AGATGGAAGGCACAGAA TTCTTCCTCTCAGGCTG polymerase Il (TTF2), mRNA AGGTGCGACTGGAAAC
165 94762 32940594 3138476 TTF2 NM 003594 ILMN 1787013
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe Id
Homo sapiens Usher TGGATAG I I I I I I GCCCT
TGCCTGCCACCGCCATCTGGAGCCCACCACAGC
ANKS4A, SANS, FLJ33924 syndrome 1G (autosomal ATTGAATCATTCAGTTGG TCTTCTCCCTGTTCTCT recessive) (USH1G), mRNA TGTACAAACATGCC
23652443 7979823 72 15463 USH1G NM 173477 ILMN 1799843
Homo sapiens leucine-rich
CTGGCAGCTTCCTGCTG repeats and WD repeat CCAATGCCTCCTTCACCTACCTCACCGCCCTGAC
DKFZp434K1815 CTCCCTGTCAGAGTCAAA domain containing 1 GGACTCCAACATCGTA
GCACAAATCCTCAGG
158 17679 46380597 411 76013 LRWD1 NM 152892 (LRWD1), mRNA ILMN 1698491
Homo sapiens excision repair cross-complementing rodent repair deficiency, CTTTGTGCTGGTTGTTGAGACTCAGCAGGGAAAT
CSA, CKN1 complementation group 8 AAAGATCCTTCTGTGC (ERCC8), transcript variant 3, mRNA
48 126793 63 12057 60252254 ERCC8 NM 001007234
Homo sapiens G protein- GCTGTCCCTCCACTACA
GCAGGAGCCTTCCTTACACTTCGCCATGAGTTTC
SH120, GPR89 coupled receptor 89A GAAACCTCACAGAACACA CTGATCGACTCCAGCA (GPR89A), mRNA GCAAAGGATAAGTGC
11698929 141 62262 138 01428 GPR89A NM 016334 ILMN 1717234
Homo sapiens zinc finger, TCTGGGGTGAGTGGCTT
TAGATATTGTTCCACCATCCCCCTCCTTGGCCCT
DKFZp667O2416 DHHC-type containing 18 TCAAAGCCTTTTAGCTTT (ZDHHC18), mRNA TCCAGCACCTCAGCC TCAAGTGGGCTGAAGC
854478 175 89761 16261012 ZDHHC18 NM 032283 ILMN 1698516
Homo sapiens Holliday
URLC9, FAKTS, hFLEGI, ATGGGGTGGACAACACCGTCAGACCGGGAGAC junction recognition protein DKFZp762E1312 CAGGGCAGCTCTTCACAG
1585893 457 08093 39861844 HJURP NM 018410 (HJURP), mRNA
Homo sapiens general transcription factor NIC, CATTCCCTACTCTCTAAG
KIAA0011, TFMIC-BETA, CCACAGACACCCTACCGATAGAACAGTGGCTCA polypeptide 2, beta 110kDa GCCAAAATATCCTGAGCA TFIIIC110 GATCTTACTTGCTCCTG
(GTF3C2), transcript variant 1, AGGCTGGCAACCCC
7036393 11532727 10936434 GTF3C2 NM 001521 mRNA ILMN_1739374
Homo sapiens ankyrin repeat
AACAGAAGAGCAGGTGACGGGAGAGGAGGTTG domain 54 (ANKRD54), GAGGTGTAGCGATGGAGC
23496428 374 76428 35578094 ANKRD54 NM 138797 mRNA
FLJ25412, PDZK8, Homo sapiens PDZ domain CCTCGTATGCACTCTGGCCTGCTTCTCCAGTTAC bA129M162, FLJ 34427 containing 8 (PDZD8), mRNA TTGCTTGTGTAAGAAC
89 585144 152 36429 14966846 PDZD8 NM 173791
Homo sapiens GTPase activating protein (SH3 CAGTGGAAGGCCAACCC
GCCCGTAAGAAGGAATGTTACTTTAATATTGGAC
HDH-VIM, G3BP, MGC111040 domain) binding protein 1 GGAGACGGACCCTGAGG TTTGCTCATGTGCTCG
(G3BP1), transcript variant 1, CCTTGTTCCAGAAGGA
7660893 1633 5809 1459 5227 G3BP1 NM 005754 mRNA ILMNJI 701477
Homo sapiens retmoblastoma- p107, PRB1, MGC40006, GTACCACCGCCATTCAGAGTTGTCTCACCCCTTC like 1 (p107) (RBL1), transcript CP107 TCGTGCCTTTTCTCTC variant 1 , mRNA
14460508 77 59388 60 594433 RBL1 NM 002895
Homo sapiens protein arginine
SKB1. HRMT1L5, IBP72, GGTGCAGTACATCTATGGGCTGTGATTCCCCTT methyltransferase 5 (PRMT5), SKB1HS, JBP1 GCCCATCAGAGAGGAGC transcript variant 2, mRNA
4498351 8777018 797 3684 PRMT5 NM 001039619
pOS + no GFs
Synonyms Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe.Sequence ^^
Homo sapiens REX1 , RNA ATACCGTGTTGGTGGTG
REX1, EIoA-BPI, TCEB3BP1, TCTCCGGACCCCCTTCCCCCTCACCTCCAGGCA exoπuclease 1 homolog (S AATGACTATTGATGACTG EL0ABP1, KIAA1138 GGGACAGAATAAATGTT cerevisiae) (REXO1 ), mRNA TGTTAAGTGCATCTG
128 95596 3194893 279 57263 REXO1 NM 020695 ILMN 1748755
Homo sapiens DNA cross-link repair 1 A (PS02 homolog, S GTCCCCTGCCCTCCATGGGCAGTTATATTCTGCA
SNM1, KIAA0086, PSO2 cerevisiae) (DCLRE1A), TCAAGCCTTAGAAGAG
47488747 11840178 10245595 DCLRE1A NM 014881 mRNA
Homo sapiens AT hook TTTCGAAGGCCGCCGTG
ELYS, TMBS62, MSTP108, GACAGTGTGAAAGCAGTGCGAGTGCGGCCTTTT containing transcription factor ACCTCTTCAAGGGCGTG MST108, DKFZp434N093 AGTCAGGTTAGTGATGG 1 (AHCTF1), mRNA GAGACGGGAAGGAAAA
19373096 46476428 40843927 AHCTF 1 NM 015446 ILMN 1720703
Homo sapiens dual specificity
GTTGTCGCAAAGGGGATAATCTGGGAAAGACAC
MKP3, PYST1 phosphatase 6 (DUSP6), CAAATCATGGGCTCACT transcript variant 2, mRNA
9428131 8476851 6096226 DUSP6 NM 022652
Homo sapiens zinc finger,
GGGAGCTCAAGGGGTTA
RACK7, PRO2893, PRKCBP1, MYND-type containing 8 CGGGAGTTTCGGCACAGACTATCCCATCAAGCC GCATGAGTGAGAACATC ZMYND8, MGC31836 (ZMYND8), transcript variant GTTGGCTCCTTTCAGCT TTCCCTGAACTCTCGT
74 82347 168 59763 148 03094 ZMYND8 NM 183047 1, mRNA ILMN 1746831
Homo sapiens glycerol kinase
CGTATGGAGTCTCGAACCCGAGGATTTGTCTGC
GKD, GK1 (GK), transcript variant 1, CGTCACGATGGAGCGGT
87 46965 11873095 112 422615 GK NM 203391 mRNA
Homo sapiens internexm CGCTTCGTACCCAGCCA
NF-66, NEF5, MGC12702, GGACAGTCAGCTCTTCATCTGCCCAACTGTGTA neuronal intermediate filament GCACTATGTGTACATGTT TXBP-1 GCATCTGCATTGCCCAG protein, alpha (INA), mRNA CCTGGTGAAATGGCA
127 32507 192 70595 18059763 INA NM 032727 ILMN 1697309
Homo sapiens hypothetical GACATTGGCTGCTGAAT
CTCTGAAGCTCCTTCTCCCACACTGCACCTACTC
SOLO protein FLJ10357 (FLJ10357), GGTCCTATCTGCTGGCT CTTGAGGCTGAACTGG mRNA CTCCCCTGAGATCTGG
44 175137 5955816 57 331932 FLJ10357 ILMN 1716105
Homo sapiens coiled-coil CTGCAGACACATACACAA
CGTACTTGCTCTGTGCTGCTTCGAGCCCCTAAG
FLJ 32745 domain containing 138 CCCGTTTGCTGCAGAGC (CCDC138), mRNA CGGACCCAGTGGCTA CTTGATCTTCAAATACT
24 49707 999268 84 75903 CCDC138 NM 144978 ILMN 1813386
GGCTCTTTTACTGCATTG
Homo sapiens spermine CTGACAGAAGCACTGTCGCTCTATGAAGAACAG
SpS, SPMSY, MRSR, SRS AGTCTTAAAAGGGGGGT synthase (SMS), mRNA CTGGGGCGCCTGTATTG
TGAATTCCGAAGGGA
13648018 25176143 22966892 SMS NM 004595 ILMN 1686477
Homo sapiens chromosome 9
RP11-545E17 7, HSPC109, CTGCCTGGCTCCTCCTTGAGGCTGGAACTCTCT open reading frame 114 MGC29492, DKFZP566D143 CCAGGGTGGTTAACTCT
27988095 47548096 43901428 C9ORF114 NM 016390 (C9orf114), mRNA
Homo sapiens phosphohpase
FLJ11281, PLA2P, PLAP, ATGCTGTAGATTTATCCTAAATTTGCTGTAGCAG A2-actιvatιπg protein (PLAA), FLJ 12699 TGGGGAAGAGGGACGG transcript variant 1 , mRNA
7003271 16008096 13975595 PLAA NM 001031689
Homo sapiens SUMO1 GCACTTCCTCCCATGAC
SUA1, AOS1, HSPC140, TGCGGCTCAAGTCACTCAGAGGCTGTTGCATTT activating enzyme subunit 1 CTTACAGTAACCATACTG FLJ3091 CAGGGCTATGTTGGTCC (SAE1), mRNA ATTGAATCCCCAGGG
63552725 8885373 8461 331 SAE1 NM 005500 ILMN 1728258
pOS + no GFs
Synonyms _ . , Probe Sequence Probe_Sequence_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens caspase 6, apoptosis-rθlatθd cysteine GCACCTGCGCAGATAGAGACAATCTTACCCGCA
MCH2 peptidase (CASP6), transcript GGTTTTCAGATCTAGGA variant alpha, mRNA
45399323 65647835 61 888664 CASP6 NM_001226
Homo sapiens GDNF family
NTNRA, RETL2, TRNR2, CTCTGGTGGGGGCTCCTGATCCGCATCCAAGCT receptor alpha 2 (GFRA2), NRTNR-ALPHA, GDNFRB TAACCAAGGCTCCAATA
39764137 10032924 93 993225 GFRA2 NMJ301495 mRNA
Homo sapiens HIV-1 Tat
ESA1 , HTATIP1, KAT5, TIP60, interacting protein, 6OkDa GCGGGGAGAGGCCACAGATCACCATCAATGAGA TIP, PLIP, CPLA2 (HTATIP), transcript variant 3, TTAGTGAAATCACCAGC
31 449047 67 48719 59891647 HTATIP NM_182709 mRNA
Homo sapiens splicing factor
ACAGGATCCCCCAGAGACCCCATTTGCCTCTCA
SAP61, PRPF9, SF3a60, PRP9 3a, subunit 3, 6OkDa (SF3A3), ACACTCAGACCTTCAAC
891 6184 1051 1143 1043406 SF3A3 NMJTO6802 mRNA
Homo sapiens v-maf musculoaponeurotic
ACCTGCGGCTCAGAGCGGAGGGGAGACTGACC
U-MAF fibrosarcoma oncogene GGAGCGCGGATCGGGACA homolog F (avian) (MAFF),
138 93512 23875595 21925595 MAFF NMJ312323 transcript variant 1 , mRNA Homo sapiens GINS complex
GGCCCATTAGACTGTTTGCAGGGCATCACTGCT
FLJ13912, PSF3 subunit 3 (Psf3 homolog) TCCCCCTGACACCTCAC
10068758 37026428 29965594 GINS3 NMJ322770 (GINS3), mRNA Homo sapiens cenlrosomal
CAGCAAGGGGTCTTTGTGCAGTTGGAGATGCTG
KIAA1052 protein 164kDa (CEP164), CCGTTGTGGCAGAGCGT
16984763 21532262 20807262 CEP164 NM_014956 mRNA
Homo sapiens sarcoma antigen NY-SAR-48 (NY-SAR- CGCAGAGGCAAGCAAAGAGGCAGCCTTGGCAAA
MGC20533 48), transcript variant 1 , CCAGGAAGTCTGGGAAG
38 320362 10885595 93 71022 NY-SAR-48 NM_033417 mRNA
DKFZp434P0810, Homo sapiens M-phase AGGACAGGGCAAGGGAG
CCAGCCACTGGTAACCATTCTTCTACTCTGTATG DKFZp434B0435, MPP-1, phosphoprotein 1 GAAAGATAGGTACAGGA CCCATGAGGTCAATTG KRMP1. MPP1 (MPHOSPH1), mRNA GTCCACAGGAGGCCAG
237 62262 1429 9309 10802059 MPHOSPH1 NM_016195 ILMN 1775688
Homo sapiens peter pan
SSF1. MGC14226, SSF2, TGAGGACCTGTTCCCCGAGGCCAAGCAGAAACG homolog (Drosophila) (PPAN), BXDC3, SSF, MGC45852 GCTTGCCAAGTCTCCAG
173 1518 25370595 23802261 PPAN NM_020230 mRNA
Homo sapiens
GAAGCTGGAGGCAGCAT serine/threonine kinase CAAGTGTCAGATGAAGGGAGGTGGAGTTATCCT
MAWD, PT-WD, UNRIP AAAGGACTCAAGGACCA receptor associated protein CTTATAGTACAGTGGCC CAGCCTCTGCCCACCA
1774 9143 2312 5476 22166812 STRAP NM_007178 (STRAP), mRNA ILMN 1760288
GCCAAGCCCAGGTCACA
Homo sapiens ZTO finger GATCTTCCCCCGACCAT CTCAGAGCTCATTAGACATCGGAGAGTTCATGCC
ZSC AN 11 protein 232 (ZNF232), mRNA GCTGGGAATCCAGAAA AGAAAAGAGCCTTCCC
54063 107 78512 9600595 ZNF232 NM_014519 ILMN 1753112
Homo sapiens S phase cyclin
KIAA1454, Zfp291, FLJ31533, CCAAGACTATCTTGAGCTGGCTAACAGATTTCCT A-associated protein in the ER ZNF291, MSTP063, FLJ31953 CAGCAGGCCTGGGAAG (SCAPER), mRNA
57 62902 98 393456 90772705 SCAPER NM_020843
Homo sapiens kinesin heavy
CCTTGCCCACTCCTAGAGACAGCTGTGCTCACTT
HK2, KIF2 chain member 2A (KIF2A), TTCCTGCTTTGTGCCT
337 18097 4388643 4202726 KIF2A NM 004520 mRNA
pOS * no GFs
Synonyms Probe_Sequence Probβ_Sequence_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens zinc finger
ZKSCAN19, DKFZp686K08243, protein 274 (ZNF274), CCTTGCCTTTTCAGCTTGACCCTGCAATATAACA FLJ37843, HFB101. ZF2 transcript variant ZNF274b, TGCACAGGCCTGCTTG
35697263 45383093 43659763 ZNF274 NM 016324 mRNA
Homo sapiens family with TCCAGCTGCTGGAATCC
GGCTTGTGCAGCTGGCAGTGTTCCTGCCCCAGC
FLJ14668 sequence similarity 136, TACCATCCCAGGAGGCA ATGGCACCTTATTGTTT member A (FAM136A), mRNA GGCACAGCCAGGGAGA
39443927 632 42676 56657263 FAM136A NM 032822 ILMN 1715760
Homo sapiens nuclear
GCCAAGACTCCCATGCTGCCTCATTTGTATTCAA
NY-SAR-105, C11orf14 receptor interacting protein 3 GCCTTTAACAGGAGGG
187 26012 9846809 764 9143 NRIP3 NM 020645 (NRIP3), mRNA
Homo sapiens transcription elongation factor B (SIII), GGCACGATAAAAGCCATGTTGAGTGGCCCAGGT
SIII polypeptide 1 (15kDa, elongin CAGTTTGCTGAGAACGA C) (TCEBI), mRNA
3107 4644 38943394 37492393 TCEB1 NM 005648
Homo sapiens TYRO3 protein
CGGTGACCTTTAGTGCCAACTTCCCCTCTAACTG
Sky, BYK1 RSE, Brt, Tif, Dtk tyrosine kinase (TYRO3), GACAGCCTCTTCTGTC
8070403 28733093 231 11429 TYRO3 NM 006293 mRNA
Homo sapiens ATPase, class
GTCTTTGTAATTTTCACAACCGCTGTCCATTGTTT
ATPIQ, ATPIG Vl, type 11C (ATP11C), GAGGATGTTACCTAC transcript variant 1 , mRNA
2944018 40363513 37881012 ATP11C NM 173694
Homo sapiens SERTA domain
GAATCTAGTCCTGGGCAACTTCACATCCGTCCTC
TRIP-Br1, SEI1 containing 1 (SERTAD1), CTGTCTCAGGGCTGGC
10120643 1669906 15229976 SERTAD1 NM 013376 mRNA
ODF84, MGC9034, Homo sapiens outer dense cccAAGGCTCCCTTCCCAAGCTCAGTGCAAACC
MGC111096, ODF2/2, ODF2/1 , fiber of sperm tails 2 (0DF2),
TCTCACTCCCAAGTTTC
FLJ44866 transcript variant 1 , mRNA
534 7018 86083923 791 22266 ODF2 NM 002540
Homo sapiens zinc finger ACACCAGGAGTCAACAAACTGTGGCCATTGGCC
OTK18 protein 175 (ZNF175), mRNA AAATATGGCCTCCCAAC
79286385 15520178 145 16847 ZNF175 NM 007147
„ . TCCCTCTGTGGCTATGG
Homo sapiens metallothionein rτΛτr.nΛΥrrn~rΥrτr CTGTCCCGCTGCGTGTTTTCCTCTTGATCGGGA
MT1. MT-1I 1X (MT1X), mRNA CTATGGATGCGGCTCTG ACTCCTGCTTCTCCTTG
GCTCTGGCTACTATTA
789 1892 4866514 34659226 MT1X NM 005952 ILMN 1771218
Homo sapiens claudin domain
ATCAGTGGATTCCCCGTGTGTCTGTGACTGCAG
MGC33839 containing 2 (CLDND2), CCTGCCTGGGGCAGAAT
63040115 101 89763 92 52264 CLDND2 NM 152353 mRNA
Homo sapiens structural
AAGTTTTCTACCTGGGCT
SMC2L1, hCAP-E, FU10093, martenance of chromosomes GACGTTGCCTTGTCCGG AGGAAACTTGCTCAGGGTGATAATACAGTTAGGA CAPE, CAP-E 2 (SMC2), transcript vanant 1, AGGGGCTTGCAGGGT GTGTCAGGGCCCATGG
106814285 37506012 29694345 SMC2 NM 001042550 mRNA ILMN 1787844
ICAP1B, ICAP-1alpha, ICAP1A, Homo sapiens integrin beta 1
CTGGCTCTGAAGACCACAGATGCAAGCAATGAG
ICAP1. ICAP-1B, binding protein 1 (ITGB1BP1), GAATACAGCCTGTGGGT
DKFZp686K08158, ICAP-1A NM Q04763 transcript variant 1 , mRNA
2343 106 3072 5977 29192893 ITGB1BP1
Homo sapiens piggyBac dJ874C204, SCAND4, HUCEP- CACAGAGCCTGTAACCCAGGTGCTTCTCTAGAC transposable element derived 4 CCCTTGGATTTTCGGAG
49875755 132 00595 10866012 PGBD1 NM 032507 1 (PGBD1), mRNA
pOS + no GFs
Synonyms Qβnbank Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Description Probe Id
Homo sapiens centromere AGAATGCTGGTTCTACAT
TGCAGGCCGAGTTACTCTCTTCCCAAAGGATGT
CENP-A protein A (CENPA), transcript CCCGAGGAGTGTCTGAG GCAACTGGCCCGGAGGA variant 2, mRNA GTGCGCCCCACTCTG
92 17047 28993097 237 63512 CENPA NM 001042426 ILMN 1725014
Homo sapiens pannexin 2 CCTCAGCCATGGAGACCATGTCATGCAGAATTAA hPANX2, MGC119432
13571011 26943927 23883095 PANX2 NM 052839 (PANX2), mRNA CAAGGTAGCACCGAGC
Homo sapiens GTP-bindmg
ATGGGCTAGGTAAAAGGGGGCTGCTTTTCTGTT
HSPC135 protein 8 (putative) (GTPBP8), AAGCATCGATAGGTAAG transcript variant 1 , mRNA
18396428 226 16013 21839345 GTPBP8 NM 014170
HSP105B, DKFZp686M05240, Homo sapiens heat shock AAGAGATGCCTGGGCGT
CCTGCCAAGGTAGTTTTCTTGCATTTTGCTCTCC HSP105, HSP105A, NY-CO-25, 105kDa/110kDa protein 1 CACCATGCCACAGCTAC ATTCAGCATGTGTGTG KIAA0201 (HSPH1), mRNA CCACTTGTTGCCACCA
10636226 21203977 18933726 HSPH1 NM 006644 ILMN 1654156
Homo sapiens coiled-coil
GGCAAAGAAAACCACTA domain containing 32 TGGGGCTGGCATGTGTGACTGTCTCGGATGAAG
MGC20481 , FLJ25915 GGACCACCAGGAGCACA (CCDC32), transcript variant TGACTGACCCAGTGCAC CAACCCCAGACCCACG
33491653 51 75229 48307663 CCDC32 NM 001080791 3, mRNA ILMN 1663723
Homo sapiens cyclin- GCCATTTGGAAGCTTTG
GGATCCCTGATCCCATTTTCCTCTGACGTCCACC p33(CDK2) dependent kinase 2 (CDK2), GTTATGAAACATGTGGA TCCTACCCCATAGGAG transcript variant 1 , mRNA GTGTATTAAGTGCAGC
52342676 10594559 931 98926 CDK2 NM 001798 ILMN 1749575
Homo sapiens TSR2, 2OS AGGTCAGGGGTCAGAAG
RP1-112K52, DT1P1A10, GGAATTCGAAGACCTTGGCTAGGTGGTGAGCTT rRNA accumulation, homolog GAACAGGGCTGCAGCGT MGC20451 GGAAGAGCTGGGCTTTG (S cerevisiae) (TSR2), mRNA CAGGGTCCGAGAGGTT
508 13928 6509309 624 5226 TSR2 NM 058163 ILMN 1672157
Homo sapiens heterogeneous nuclear nbonucleoprotetn A1 TTATGGAGGAGGCGGCCCTGGTTACTCTGGAGG
MGC102835, HNRNPA1 (HNRNPA1), transcript variant AAGCAGAGGCTATGGAA 2, mRNA
130 13928 295 12262 25440594 HNRNPA1 NM 031157
Homo sapiens translocase of outer mitochondrial membrane
TOM20, M0M19, KIAA0016, 20 homolog (yeast) GTAATCAGCTTGTTGTAGTGATGCTGGCCAAATG MGC117367, MAS20 (TOMM20), nuclear gene GTGCTCAGCAGGTGAG encoding mitochondrial protein, mRNA
1729 5559 1984 3893 19354017 TOMM20 NM 014765
PREDICTED Homo sapiens
ATAATGTTAGCTTACAAGCTGGGAATATAAGTGC zinc finger protein 703 ATTAACGGCCCACATG
32 685837 11529762 92 11445 ZNF703 XM 001129663 (ZNF703), mRNA
Homo sapiens DEAD (Asp-Glu GACTGCAGACTTCCTGA
MGC9936, KIAA0801, TGGCAGTCCCACATCGATGATAATTGGTGCTCC Ala-Asp) box polypeptide 46 GGGCACAGCCCACCCCT FLJ25329 CTTCATCCAACTGGATC (DDX46), mRNA CATGCTTTGAGTTTCT
162 57678 247 53094 233 17262 DDX46 NM 014829 ILMN 1701881
Homo sapiens heterogeneous
OK/SW-cl 23, HNRNPF, mcs94- nuclear nbonucleoprotein F AGCAGCACACATTCTGGGAAGCATCAAATAGACA 1. MGC110997 (HNRNPF)1 transcript variant CACGGCCCCAGCCACC 2, mRNA
77 540054 11477678 131 20178 HNRNPF NM 001098204
pOS + no GFs
Synonyms Probβ Sequβncβ Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens zinc finger, ACCAAGTGAGGAAGACC
CAGGCAGTCTGTGTGGTTACAGCGCCCCTCAGT
MIZIP, RP11-48C74 MYND-type containing 19 CAACCTTTGAAGACAACC GTTCATCTCCAGCAGAG (ZMYND19), mRNA CTGAAGTGCCTCCGC
31591428 41555594 457 2143 ZMYND19 NM 138462 ILMN 1739683
Homo sapiens zinc finger and TTATTGGGCAGGGGGAG
TGGGGCTCCTGAAACACCTCGTTTTGAAGGTGA
ZNF450, BIF1. PATZ2 BTB domain containing 24 GGGGAGGGCACAGGCA ATCTTTGGTTTTCTCCC (ZBTB24), mRNA AGAAGAGATTCACAGTG
114 89345 141 96428 151 82678 ZBTB24 NM_014797 ILMN 1693975
Homo sapiens cyclin H CCAAACATGAGGAGGAAGAATGGACTGATGACG CAK, p34, p37
48923096 807 7893 937 8976 CCNH NM 001239 (CCNH), mRNA ACCTGGTAGAATCTCTC
Homo sapiens small nuclear
GCCTTCGTGGAGTTTGACAATGAGGTACAGGCA U1A πbonucleoprotein polypeptide GGGGCAGCTCGCGATGC A (SNRPA), mRNA
5422976 76564343 8607143 SNRPA NM 004596
Homo sapiens Tu translation elongation factor, CGAGGGATCTGACCTAC
CAGCGTTTCACCCTGCGAGATGGCAACCGGACT
COXPD4, EF-TuMT, EFTU mitochondrial (TUFM), nuclear CAGGTGGTGTTGGGTGA ATTGGCACCGGTCTAGT gene encoding mitochondrial GTACAACCTTGCTGTG protein, mRNA
14230559 1628 9727 17006893 TUFM NM 003321 ILMN 1677559
Homo sapiens integrin, alpha GGAGAGTGCAGGGATAT
GTCCTGAAAAGGGTGTTGGGAGGGTGGTTCAAC
VLA-6, ITGA6B, CD49f 6 (ITGA6), transcript variant 2, AAGAGGAAATGGGCAGC AAAGAAACAAAGATGTT mRNA TGGGGTAAGGAAGGGG
72 91463 422 34763 7099768 ITGA6 NM 000210 ILMN 1800000
Homo sapiens RNA binding
GAACCCTGGGATGCTCTAATTGGCTGGTTGGTT MGC2734, RP11-498E22 motif protein 18 (RBM18), TGGATTTGTAACTCCAG
127 83095 16578513 17846011 RBM18 NM 033117 mRNA
CCTCAGGCCACAGACTT
Homo sapiens brix domain TGGGACCCTCATTGGATCTGGTTCTGAGGAGGA FLJ21087, RPF2, bA397G54 GTAGTAATCATTTGAAGG containing 1 (BXDC1), mRNA CACACCTGGCATCGGAT CCTCACCTAGTGTCC
1112 5809 1668631 1884 0726 BXDC 1 NM 032194 ILMN 1795336
Homo sapiens fibrinogen
MGC119425, MGC119423, TCCTTGGGGGCAGGGCCTTTGTCTGTCTCATCT alpha chain (FGA), transcript Fιb2, MGC119422 CTGTATTCCCAAATGCC variant alpha, mRNA
14998929 28685178 348 32678 FGA NM 021871
Homo sapiens pro.easome CAGAGAAACTCACCACA
MGC22756, IOTA, MGC2333, (prosome. macrapain) subun,., GTGTTTπ CATTGTCGTTAGTTTACCAGATCCGTGATGCCAC p27K, PROS27, MGC23846 alpha type, 6 (PSMA6), TTACCTGTGTGTTTGG
CATGATGCCCAGATG
56208228 69054062 7376 1978 PSMA6 NM 002791 mRNA ILMN 1660541
HC56, p97, DKFZP434B131 , Homo sapiens gem (nuclear
GCTTCTTACCTGTGCGGGAGCGAAAAAGCTGGG DKFZP434D174, HHRF-1, organelle) associated protein CTTCAACATGGCAGGTC HCAP1 4 (GEMIN4), mRNA
413 03094 890 70593 1134 7893 GEMIN4 NM 015721
Homo sapiens zinc finger, GCCACGAGAACATCGAC
GGTCCTTTGGAGGCCCTACCCCTTCCCCATTCAT
MGC 104290, C20orf99 CCHC domain containing 3 CTCAGAAGGACTGGAGG TGCCACCAGTGAGAAA (ZCC HC3), mRNA AAGGTGAAGTGGAGGG
56344387 60 35604 63 147316 ZCCHC3 NM 033089 ILMN 1801907
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens TAF15 RNA polymerase H, TATA box
GCTTTGTTTTCCCACACA
TAFII68, TAF2N, RBP56, binding protein (TBP)- TTGCCAGAGTTTTGCCTGCTGCTTTCCTCGTGGC TATTCAAATCAGCAAGCT hTAFII68, Npl3 associated factor, 68kDa CTCTTCTTGGGTAGTG TGTAGCTGGACTGC (TAF15), transcript variant 1,
2229181 3685406 4334481 TAF15 NM 139215 mRNA ILMN 1803748
Homo sapiens transportin 1 TGCTGTCTGGAGCAGCA
CAGTCTTGGAGACTATAAGGGAGCCTCTGCACC
TRN, IPO2, KPNB2, MIP, MIP1 (TNPO1 ), transcript variant 2, GGATCCCGGGACAGGAT CAGGGAAAATGTTACCC mRNA GGGGGGCTTTGGGGAA
80146844 10422476 11359143 TNPO1 NM 153188 ILMN 1672653
Homo sapiens chaperonin ATGGCCCCAGTCCATGC
MGC126164, Cctd, TAATGATCCAAGTGGCACCTCTCTGAACCTACTT containing TCP1, subunit 4 TTCTAGCCTTGGTTCCTT MGC126165, SRB TGGCTTGGGAGGCTGC (delta) (CCT4), mRNA CTGCCCCTCTGTTTG
11831845 20109763 23758511 CCT4 NM 006430 ILMN 1728858
Homo sapiens DNA-damage- CGGACCCAGAACATTCT
AGCTCCAAAGGTTCACTGTGTTTCTGCCGCTGTC
Rtp801L, REDD2 inducible transcript 4-lιke CCAGTAGTGCATTCAGTT CTGGAGTTGTCACCAC (DDIT4L), mRNA CAACACAGCAAGTGC
13055626 122243454 25938095 DDIT4L NM 145244 ILMN 1673369
Homo sapiens proline/seπne-
RP11-297O4 2, MGC1780, CCTGAATCGCATTCTCTACTGGACTCTGGCCTGC rich coiled-coil 1 (PSRC1), FP3214, DDA3 TTGGAGAGGTGGCAGC transcript variant 4, mRNA
18363095 29766846 37409763 PSRC1 NM 001032290
Homo sapiens tumor protein
CTCCTGGATAGTTCCAAA p53BP2, ASPP2, 53BP2, p53 binding protein, 2 CATCATGTTGGCCAGGATGGTCTCGATCTCCTG
CATCTTCCTTGTGGCAG PPP1R13A1 BBP (TP53BP2), transcript variant ACCTTGTGATCCGCCTG
GTTTCCTGGCTGAGC
24109648 18913095 3817976 TP53BP2 NM 005426 2, mRNA ILMN 1724487
Homo sapiens chromosome
CAGTGTGTCAGGCAATC
21 open reading frame 51 CACAGTCTACCATGAATTGGAAGGTTCTTGAGCA
TGGACTTTGCCCTCAAAA
(C21orf51), transcript variant CGTGCCCCTGCTGCTG GAGCAGTGGTTCCTG
22253094 6137018 8406726 C21ORF51 NM 001042401 2, mRNA ILMN 1696031
Homo sapiens centrosomal
CCCAGCATTACATCAACATGCCCGTGCAGTTCAA protein 192kDa (CEP192), ACCGAAGTCCGCAGGC
15825179 27288095 33024347 CEP192 NM 032142 mRNA
Homo sapiens CDC-like CACTGCTGGCTGCCCAT
AAGATGACAAGGAGGGTCACCTGGTGTGCCGGA
FLJ22858 kinase 3 (CLK3), transcript TGCTGTGGATGGGGTAG TCGGCGATTGGCTCCAA variant phclk3, mRNA AGCTGGAGTCACACAT
13751428 2781351 3403976 CLK3 NM 003992 ILMN 1676247
Homo sapiens 28S nbosomal GCGGGCCGCCGGTGAAATACCACTACTCTGATC RNA (LOC100008589) G I I I I I I CACTGACCCG
15318477 45891226 63511226 LOC100008589 NR 003287
CTTGGTGCTGATGGCCT
C20orf155, GCD10, CLS1 , Homo sapiens cardiolipiπ GTGAATACAGCAGTCCAGTTAATCTTGGTGGCA GAAGGGGCCTGAGCTGT dJ967N21 6 synthase 1 (CRLS1), mRNA GCTTCTTTGGCAGCTCC GGGCAGATGCAGTTTT
1487006 21185476 23639312 CRLS1 NM 019095 ILMNJ 757552
CCTCATAGTGAGCCAGA
Homo sapiens lymphocyte TGGGAGCCCAGAAGAAATGCTCTTTTGCTTGGA
MD-2 AGCAGCCTCATAACCCT antigen 96 (LY96), mRNA GTTTGTCATCCTACACC
GAATGTGGGGCTCTGG
23245596 2832976 29444345 LY96 NM 015364 ILMN 1815628
Homo sapiens far upstream
CACTGGCATG I M I I
FBP, FUBP element (FUSE) binding GTAGATTGGAGGATCT
24084644 61679188 81160286 FUBP1 NM 003902 protein 1 (FUBP1 ), mRNA
pOS + no GFs
Synonyms Probe__Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens hydroxysteroid TCTGGAAAGTCCTGGGG
GGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGG
MFE-2 (17-beta) dehydrogenase 4 AACTCGCAGGGCACGGG GAACATCATGCTGAGCC (HSD17B4), mRNA CCGCTGTCGCGGTTGG
7950476 1597 8059 2005 1685 HSD17B4 NM 000414 ILMN 1741592
Homo sapiens elongation GAGGTCCTCTGTGTTTG
CU68P15A 1, PAXNEB, AAAATGGATCTGGCAGAATCCGCCAAGCGGCTG protein 4 homolog (S AGACAATCCTGTGTGTG C11orf19, PAX6NEB, FLJ20498 GGCCCAGGCTGTGGCAT cerevisiae) (ELP4), mRNA CCAGGAGGCTCCGTGT
81 61041 111 52261 12256845 ELP4 NM_019040 ILMN 1789405
Homo sapiens zinc finger,
DKFZp686J1831, RAN-binding domain AAACAACCCTGAGCCCAGGGCCAACCCCTACGG DKFZp686N09117, ZIS2, ZIS1, containing 2 (ZRANB2), AACACCACTACTTTACC FLJ41119, ZIS, ZNF265 NM Q05455
199 18927 2846018 317 05176 ZRANB2 transcript variant 2, mRNA Homo sapiens fasciculation
GCCTCCTGAGCAAGGTA and elongation protein zeta 1 GGTGGGGGATATGTTTTAAGACCCCCAGTTAAT CCATGGCTGCCAGACTT (zygin I) (FEZI), transcript GCCTGAAACCGCTGCTA CAGGTGAACTCAAAGG
69 16031 107 62262 12923097 FEZ1 NM_022549 variant 2, mRNA ILMN 1687835 Homo sapiens plastin 1 (I CTTTCTCCATCTTCCACTGTTAGTGCCAGTGAGC
I-PLASTIN
20682758 82 376976 12481012 PLS1 NM 002670 tsoform) (PLS1), mRNA AATACTGTTGTGCAAC
Homo sapiens protein inhibitor CAAAGGCACAGTTTAGA
MGC35296, ZMIZ6, Piasg, TTTCCACCCTTTTGCCTGGCTCCTGGCACCTGTA of activated STAT, 4 (PIAS4), GGATTGGGGGAAGGGA FLJ12419, PIASY CCTCTGGACTCTCCTA mRNA GAACGAACCCAGGGAGC
41073926 777 70593 932 58923 PIAS4 NM_015897 ILMN 1738622
C15orf3, PNAS-22 PTD014, Homo sapiens EP300 MGC138883, IRO45620, EID-1, interacting inhibitor of GCTGGTCTGGGAAAACCTGCCCTATCAATGAGT CRH, RBP21. MGC138884, differentiation 1 (EID1), ATGTTGCCGTGGTTACC
80 70643 10723104 11396846 EID1 EID1 NM_014335 mRNA
Homo sapiens hydroxyacyl- Coenzyme A dehydrogenase/3 ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A CTTCCCTGGCCTTGAGT
LCHAD, MGC1728, HADH, TP- GCAGATGCTTTGCCCAGGCTTCTCACCACGGTG hydratase (tnfunctional AGAAAAGTCGGGGATCG ALPHA, MTPA, GBP TACCGGGATATTAAACC protein), alpha subunit GGGCAAGAGAGGCTGA (HADHA), nuclear gene encoding mitochondrial protein, mRNA
262 91428 281 93097 29023096 HADHA NM 000182 ILMN 1809931
Homo sapiens leucine zipper- EF-hand containing
GATCCCTTCCGGGCTCT transmembrane protein 1 GGTCTATCTTGTCTCCTT (LETM1 ), nuclear gene AGCTGGGGGCCTACA encoding mitochondrial
7083869 122 65595 148 39761 LETM1 NM 012318 protein, mRNA ILMN 1803743
GAGAGAGACCCGTTTCC
Homo sapiens glypican 6
MGC126288 TTTCAGGGATGTGGACA (GPC6), mRNA GGGTAAGGGCAGCAAG
4869568 91 16849 11397262 GPC6 NM 005708 ILMN 1787922
Homo sapiens transcription factor B2, mitochondrial TTGCAGGGGCCCGAGAC
FLJ22661, Hkp1, FLJ23182 (TFB2M), nuclear gene CCCACCATTGCACTCCA encoding mitochondrial GTCCGGGAAACAAGAA
89808093 1111 0227 1192031 TFB2M NM 022366 protein, mRNA ILMN 1771320
pOS + no GFs
Synonyms Probe_Sequeπce Probe_Sequβnce_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens 3-
AATGGAGCAGGATATTG
MGC20087, MGC35290, PDK1, phosphomositide dependent GTGTCTGCTTTAGAGTACTTGCACGGCAAGGGC CTGAAGTCTCCTGGCAT PRO0461, PkB-like, PkB-like 1 protein kιnase-1 (PDPK1), ATCATTCACAGGGACCT ATGTTACCGAATCAAA transcript variant 1 , mRNA
24620595 411 60178 48894763 PDPK1 NM 002613 ILMN_1672783
GAAGACAAAAGGTCTGC
Homo sapiens citrate lyase
AAGGAACCACTGCACTTT TCGACATGCCATTACTGAAGCAGGCCCAGAACA bA134O15 1, CLB beta like (CLYBL), mRNA CTGTTACGCTTGCCACC CCAGACAAGCAGGCC
20604572 90649994 14526012 CLYBL NM 206808 ILMN 1701077
Homo sapiens zinc finger
GTAAGGGTGGCAAGGTCTTCACTCTGTGGTCAT
MGC125619 protein 816A (ZNF816A), TCCATGCAGAACATCAG
67 74475 87 82377 94 56439 ZNF816A NM_001031665 mRNA
PIN, DLC1, MGC126137, DLC8, Homo sapiens dynein, light CAGCGTGCATGATGGGT
TCCCACCTGGCATTGCATCGTGGGGAGGAACTT DNCL1. MGC126138, LC8a, chain, LC8-type 1 (DYNLL1), GTGACCTTCTGTGCCAAT CGGTAGTTATGTGACAC hdld, LC8, DNCLC1 transcript variant 1 , mRNA AACCTTGTCAACCAC
67734062 7431 1562 77107646 DYNLL1 NM 001037494 ILMN 1720694
Homo sapiens LAG1 homolog,
SP260, CerS2, MGC987, CTACCTCTGCCAAAAAGTGGGGGCTGTACTGGG ceramidθ synthase 2 (LASS2), TMSG1. L3, FLJ10243 GACTGCTCGGATGATCT transcript variant 1 , mRNA
666 5476 7698268 807 11426 LASS2 NM 181746
Homo sapiens EDAR- associatθd death domatn GCAACATTTGTAGGGGCCGCTGCTAGTTAGCTA
ED3, EDA3 (EDARADD), transcript variant CCCTTGCCCACCGCCGT
58268852 156 97678 22590594 EDARADD NM 145861 A, mRNA
Homo sapiens hsp70-
GGAGCTGCTGGCCGACCTGTGTGAGAACATGGA iπteracting protein (HSPBP1 ),
CAATGCCGCAGACTTCT
159 5476 2000476 21022678 HSPBP1 NM 012267 mRNA
Homo sapiens phosphatidylinositol glycan
GPI2, MGC2049 anchor biosynthesis, class C TGGTGACATTTGCCATTCAGATTTTTGCCCTGTG GCCCATGTTGCAGAAG (PIGC), transcript variant 1,
119 805954 141 53928 15088095 PIGC NM 153747 mRNA
Homo sap,ens chromobox CAGGCAGACACTAACGT
HP1 -GAMMA, HP1Hs-gamma, homolog 3 (HP1 gamma GCTGAGGAGACTCCGGTCACTGTCCTCGCCCCG HECH homo,og. DrOSOPhIIa) (CBX3), « G CCTCCCCCTTCCCTCCC transcript variant 1, mRNA
31 961887 73 58183 9845178 CBX3 NM 007276 ILMN 1659982
Homo sapiens proteasome
GCTGGATTTTCTCCGCCCATACACAGTGCCCAAC (prosome, macropain) subunit, AAGAAGGGGACCAGGC beta type, 7 (PSMB7), mRNA
4125656 50432227 54189478 PSMB7 NM_002799
SAC2, hSAC2, FLJ13081, Homo sapiens inositol MGC59773, MSTPO47, polyphosphate-5-phosphatase GGGGGGAGGGTTGACATTTTCCGACTGCCTGTT MSTP007, KIAA0966, F (INPP5F), transcript variant ACGTGCCAAGTGCTTTT MGC131851 2, transcribed RNA
45691605 9646429 126243454 INPP5F NR_003252
Homo sapiens homβobox C6 CTGAGTTCAGTCGGCCC
AATTCCTACTTCACTAACCCTTCCTTATCCTGCCA
CP25, HOX3C, HHO C8, HOX3 (HOXC6), transcript variant 1 , TTCCTGGTGATGACTTTC CCTCGCCGGGGGCCA mRNA CACACGGAAACAGGA
7 711319 10524346 267 53928 HOXC6 NM 004503 ILMN 1743046
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l
Raw XS pOS ♦ 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens palmitoyl- protein thioesterasβ 1 (ceroid- TTGGAGAAATGATGAGCTACGCCTTGATGAAAGA
CLN1, INCL, PPT hpofuscinosis, neuronal 1 , ACCGTGTTGGTGCTGC infantile) (PPT1), mRNA
17023226 22066143 2421 5476 PPT1 NM 000310
PREDICTED Homo sapiens
CAGGAGAAGCCGGACCTGGCTGAGAGCCCAAA CGI-96 protein (CGI-96), GGAGTCAAGGTCGAAGTT 20600179 3127976 349 1143 CGI-96 XM 001125724 mRNA
Homo sapiens target of myb1 - AGGGACCGCTTGGAGCA
TGGCACGCTGCTGAGACGACACTACCAATAAAC
FLJ32746 like 2 (chicken) (TOM1 L2), GTTAGAAAGGAAGCGGG CAAACTGCCACGCACAC transcript variant 3, mRNA AGCGGGAGCGCAAGAT
8619772 1502143 185 10596 T0M1L2 NM 001082968 ILMN 1711078
TGGTTCCCACAGCCCCA
Homo sapiens hydrolethalus CCGTTGGGGTGTTCGTTGTGACCTTGCAAATGG
FLJ 32915, HLS CGTGCCATGGAGGGACA syndrome 1 (HYLS1), mRNA TGTCATACCCAGGAAGC TGGAAGGAAAGACGAT
21368512 45003094 5900393 HYLS1 NM 145014 ILMN 1688101
Homo sapiens stomatin
TGATCGAGTCAAGATGAGTTAGTGGAGCTGGGC
HSPC108, SLP-2 (EPB72)-hke 2 (STOML2), TTGGCCAGGGAGTCTGG 2267 4976 28708809 31554727 ST0ML2 NM 013442 mRNA
Homo sapiens E2F
CCGGCCTGGTTTCGCCTGGTCGTGTCTTTATGA
E2F-2 transcription factor 2 (E2F2), GCACCATGTAAGCCTCC 4261539 15851845 298 18097 E2F2 NM 004091 mRNA
FLJ43310, MGC40204, Homo sapiens chondroitin
TGTTAGTGGGATGGCAA CSGalNAcT-2, GALNACT-2, sulfate N- TGGACGAGGACTAAATGTGGGTGCCCGAGCTTG ACACTGTGAACATTGCTG GALNACT2, acetylgalactosaminyltransfera GGACAAGGGAGAGGTCT TTTCTAGTGGGCCAG DKFZp686H13226, PRO0082 sβ 2 (CSGALNACT2), mRNA
44949226 121 15178 174 01428 CSGALNACT2 NM 018590 ILMNJ 656436
MGC27337, UMPH1,
Homo sapiens ϊ-nucleotidase, GAAGCTCATCAAGCTGA MGC87828, UMPH, CTCCAAGAAGACCTCTCTCCTGTGGGTGCAATT cytosohc III (NT5C3), AATAGCACAGCTGGCCA MGC87109, PN-I, PSN1, cN-lll GAACTGTTCATCCGTTC transcript variant 1 , mRNA ATGAAAAGCAGAAGTG 8362518 10807227 1208631 NT5C3 P5'N-1 NM 001002010 ILMN 1799999
Homo sapiens traπslocase of inner mitochondrial membrane GACAGGATGGGGTTCCC
DFNI1 DDP1 MTS, DDP1, 8 homolog A (yeast) CTGTGCTTTTACCAGTAG GATTTAGGCCAATCAGAAGCTAACAGCAGTTTCA MGC12262 (TIMM8A), nuclear gene CATGACCCCTTCTGA GGTAGAGGTGCATGCC encoding mitochondrial protein, mRNA
5035241 113 88512 1522976 TIMM8A NM 004085 ILMN 1720511
, u TGCTGCCAGGATGCCGA
CTPP2, HSPB5, CRYA2 Homo sapiens crystallm, alpha AGGATACCCCACTAGCA GTCCTCACTGTGAATGGACCAAGGAAACAGGTC B (CRYAB), mRNA CCCCTGAGGGGGTCAT TCTGGCCCTGAGCGCAC
47107393 11570639 16113 105 CRYAB NM 001885 ILMN_1686259
DKFZp781F1414, VEGF165R, Homo sapiens neuropihn 1 CTAGGAGACTGGGACAA
CCTTCCCACATTGCTAGACGTCTCACTCAAAGAC NRP, DKFZp686A03134, (NRP1 ), transcript variant 1 , GCAAAAGGCTGCAAACA
ATTTGTTGGGAGTCAC CD304 mRNA ACCCAGAAGCCCATCC
2114356 22374395 23036978 NRP1 NM 003873 ILMNJI 760718
Homo sapiens transmembrane
ATGTGGGGCTTGATTCACCCTTCATCCATTGGCT
MGC5576, MGC111210 protein 106C (TMEM106C), GGAACATGGATTGGGG mRNA
55268097 10389642 1357 8477 TMEM106C NM 024056
pOS + no GFs
Synonyms Probβ_Sβquβncβ Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Gβnbank Description Probe Id
Homo sapiens cyclm- dβpendent kinase inhibitor 3 GGAATGGGGCAATGGAT
CDM, KAP, MGC70625, (CDK2-assocιated dual CGCAGATGGAGGGACTCCTGACATAGCCAGCTG GCATTTCCCAAAACGTGT FLJ25787, CIP2, KAP1 CTGTGAAATAATGGAAG specificity phosphatase) GAAAGCACTAACAGC
33450595 93028094 14170977 CDKN3 NM 005192 (CDKN3), mRNA ILMN 1711542 Homo sapiens TIP41 , TOR
GCTTTTGCTCAGTAACTG
RP1-69E11 1. MGC3794, signaling pathway regulator- AGTGGCCTGTGCTGAAGAGTGGCAAGAAAGCAG TGTCATGAATTGCAAGAG dJ69E11 3, TIP, TIP41 like (S cerevisiae) (TIPRL), GACGGAGGGTGAACACT TTTCCACAAACACT
895 1226 10292643 10809727 TIPRL NM 152902 transcript variant 1 , mRNA ILMN 1680192 Homo sapiens
DKFZp564A0122, ACS, LPLA2, lysophospholipase 3 GGCAGTAGGCTCTAAGTGGGTGACTGGCCACAG LLPL (lysosomal phosphohpase A2) GCCGAGAAAAGGGTACA
178 36429 208 59344 21708096 LYPLA3 NM 012320 (LYPLA3), mRNA Homo sapiens lipoic acid synthetase (LIAS), nuclear
HUSSY-01, MGC23245, LIP1, GGAAATGAACTTGGATTTCATTATACTGCAAGTG gene encoding mitochondrial LAS GCCCTTTGGTGCGTTC protein, transcript variant 1 ,
100 11013 15340594 176 12262 LIAS NM 006859 mRNA
Homo sapiens multiple GTGCCTGCACCACCCCA
DKFZp686G21263, LMAN1 IP, GAGAAGAAGCAGCAGATTGTAATTTGGTTTATTG coagulation factor deficiency 2 CTGCCTTCCTTCAGCAC F5F8D, SDNSF GATGTGATGGACGTTC (MCFD2), mRNA CTTTAGCTGCATTTGT
17307262 26544345 3132726 MCFD2 NM 139279 ILMN 1741003
Homo sapiens U2 small CGGCTGTAGCAGCAAGC
CCCGTGGCCCCTGCCCCTCTCCTACTCTCTGTG
U2AF65 ?M^W 3U T ,°i AATCCCCAACCTCTGACT (U2AF2), transcript variant 1 , GCAATGACCTTTCTG GCAGTTTCATATTTGCT
24898394 3161 9395 34806643 U2AF2 NM 007279 mRNA ILMN 1691264
Homo sapiens transmembrane CCTGAGCCAGAAGTGGG
AGCCATCTCCAGGGTGACGGAACCCAGTGTATT
FLJ14627 protein 118 (TMEM118), GTGCTTATACTCCCAAAC ACCTGCTGGAACCAAGG mRNA CTTGAGTGTCCAGCC
31 474556 151 37262 26607263 TMEM118 NM 032814 ILMN 1714433
Homo sapiens matrix
STR1. STMY, MGC126102, GGCATTAGCTGACAGGC metallopeptidase 3 CCTTGTCACATAGAGTGATCTTTCCCAAGAGAAG STMY1, SL-1, MGC126103, TGGTAACAGTCCACACAA (stromelysiπ 1 , progelatiπase) GGGAAGCACTCGTGTG MGC126104, MMP-3 GATGGTATAGGCCTG (MMP3), mRNA
68 129364 2989643 553 1226 MMP3 NM 002422 ILMN 1762993
Homo sapiens zinc finger and AGAGCTGGCCGCCCAGG
AGCCATACTGTGACAGCTGGTCTGATGTCTCCCT
KUP, ZNF46 BTB domain containing 25 GGGAGTCGCAGAGTTTG GAAAAGTTCTCGCTTG (ZBTB25), mRNA GAAGATCTCTCTAACA
64 502495 83617676 9023161 ZBTB25 NM 006977 ILMN 1756826
Homo sapiens BCL2-lιke 1 bcl-xL, BCLX, (BCL2L1), nuclear gene
GTGGAAAGCGTAGACAAGGAGATGCAGGTATTG
DKFZp781P2092, BCL-XL/S, encoding mitochondrial GTGAGTCGGATCGCAGC BoI-X, bcl-xS, BCL2L protein, transcript variant 1 ,
18504346 299 3393 339 70593 BCL2L1 NM 138578 mRNA
Homo sapiens
CACTCCAAGATTATGGCCTCGGGCAAGTGCTGT
ENC-1AS hexosaminidase B (beta TGGTGAGAGACTCTGGA polypeptide) (HEXB), mRNA
3228831 4719748 5509681 HEXB NM 000521
Homo sapiens poly (ADP- GGCTGTTGTCTTCGGCT pADPRT-1, PARP-1, ADPRT1, ACCAAAGCTTCGTTAGAATGTCTGCCTTACTGGT πbose) polymerase family TGGGTGAAATGACAGTT PARP, ADPRT, PPOL TTCCCCAGGGAAGGAA member 1 (PARP1), mRNA ccTCTTCATTCTAAAG
1554 7893 24798643 30142476 PARP1 NM 001618 ILMN 1785292
pOS + no GFs
Synonyms Probe Sequeπce Probe Sequencβ l Raw XS pOS + 6 GFe Raw Raw Common Genbank Description Probe Id
Homo sapiens ribosomal protein L23a pseudogene 13 ATCCTCGGAAGACCACCCCCAGGAGAAACAAGC
DKFZp547IO14 (RPL23AP13) on chromosome TTGACCACTATGCTATC
121 76012 221 7143 28208096 RPL23AP13 NR 002229 2
Homo sapiens high-mobility
CTTTCAGCATAGACTTAACTCCCTTAAGCCCAGA
HMG17, MGC5629, MGC88718 group nucleosomal binding CATCTGTTGAGACCTG domain 2 (HMGN2), mRNA
38377476 54557144 63060894 HMGN2 NM 005517
Homo sapiens caspase 4,
CTAAGGAGTTTCCTGTAG
TX, Mιh1/TX, ICH-2, ICE(rel)ll, apoptosis-related cysteine ACTCCAAGGGCCAAAGCTCAAATGCCCACCATA
TCCTGTAATGAGTTGGC ICEREL-II peptidase (CASP4), transcript GAACGACTGTCCATGAC
CCTCAGTCATCCCCG variant alpha, mRNA
65540173 827 7893 9140893 CASP4 NM 001225 ILMN 1670093
Homo sapiens dynein, light GTTGGCGAGTCTGAGAG
TCCTCCTCTTCAAGTCAGGCTAGGTGGCCATGG
MGC17810, DNCL1B, Dlc2 chain, LC8-type 2 (DYNLL2), CAAGCCCAAATGTGTTCT TGAAGGTGTCAGTGGCG mRNA TCAAAGGACAATGGG
4052351 83357263 11082144 DYNLL2 NM 080677 ILMN 1726552
Homo sapiens coded-coil CTTCTCATCCCGGGGCA
CAAGAAAAAGTGATGCCGCCTGGCAGACTCGCC
FLJ32446 domain containing 101 AAGCAGGCATCAAAACC ATCCCCCAACGACACAG (CCDC101), mRNA AGAATAGGCCAATCTC
46255108 6344696 72 73763 CCDC101 NM 138414 ILMN 1734542
Homo sapiens A kinase
D-AKAP1, AKAP149, (PRKA) anchor protein 1 GCAGAGCGTGCACCAAT MGC1807, AKAP121, TCAGGGAGCAAGACATGAACTGACTAATTGGTAT (AKAP1), nuclear gene GAGACCACGATGGGAAA SAKAP84, PRKA1 , AKAP, CCACTACTTGTACAGC encoding mitochondrial GGGCCTATTTAACTCC AKAP84
61 344444 84 19464 9538106 AKAP1 NM 003488 protein, mRNA ILMN 1712545
Homo sapiens IK cytokine, TGCACTATGCGCCACAC
RED, MGC59741, IK protein, GGGGCCCTTAGGCCGTTGGGACTTTGATACCCA down-regulator of HLA Il (IK), CAGATGAAGGATGTGCC CSA2 GGAAGAATACAGCGAGT mRNA CCTGATTAGCCTGGCC
60344763 66858093 6993393 IK NM 006083 ILMN_1660810
Homo sapiens ACN9 homolog CAGAGGCTGTGGAGCGA
CTCTTCTCCCTGCATCACTGTTCATTCACAATGA
DC11 (S cerevisiae) (ACN9), GGGTAGTAGGAGCT AAGGTTAGGAAGAAGC mRNA CCCAGAGTGCTGTGAC
461 0976 80240594 10062893 ACN9 NM 020186 ILMN_1798288
Homo sapiens mitochondrial ribosomal protein S33
FU21123, CGI-139, PTD003, (MRPS33), nuclear gene CACACTTACGCTGAACTCATGCAGACGCTCCGAT MRP-S33 encoding mitochondrial TTCTTGGACTCTACAG protein, transcript variant 1 ,
1392 106 1733 3893 19030393 MRPS33 NM 016071 mRNA
Homo sapiens ribosomal CTTGAAGGCCTACTGTC
GCCGGCGAATCGTGGTTCTCTTTTCCTCCTTGG
DKFZp686N1586, DBA3 protein S24 (RPS24), ATCCACAAAGCTCCTTTT CTGTCTGAAGATAGATC transcript variant 2, mRNA TTACGGGCATCCCAT
15129976 3258281 4502 506 RPS24 NM_001026 ILMN 1813455
HKE2, PFD6, H2-KE2, KE-2, Homo sapiens prefoldin TTAAACTTCTGGGTCCGGTGCTAGTCAAACAGGA
26943094 361 29346 4028976 PFDN6 MGC70744 NMJM4260 subunit 6 (PFDN6), mRNA GCTGGGGGAGGCTCGG
AGCGAGGCACCCTTACT
Homo sapiens paxillin (PXN), ATGACCAGAAAGGGGCCACCGGGGTCTAATGGT
FLJ16691 GGCTTACCTCCTCATGG mRNA GACAGTCCAAACCACTC CAGCCTACTCTCCTTG
127 13928 26383093 36334763 PXN NM 002859 ILMN 1725560
pOS + no GFs
Synonyms Probβ_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens chaperonin
CCTG1 TRIC5, TCP-1 -gamma, containing TCP1, subunit 3 GCCAGGAACACTGTGGACGTCTTTGTTCAGAAG PIG48, CCT-gamma (gamma) (CCT3), transcript GGATCAGGTTGGGGGGC
472 33093 564 5393 611 381 CCT3 NM 001008800 variant 3, mRNA
Homo sapiens protein kinase, AMP-activated, gamma 1 non- GCCAGACCCCCCATCAG CAACTCACTGCCTGCTGGAAGCTCTGTGGGAAT
MGC8666 AMPKG catalytic subunit .PRKAGI), CAGATGAAACTTGAGGG transcript variant 2, mRNA
489 1601 5042601 511 05176 PRKAG1 NM 212461 ILMN 1802923
Homo sapiens small trans¬
GAGGTTGGGGAAGTGGG membrane and glycosylated AACCTACAGAAGGTGAGCCCAGTGCCATCGTCC
MGC 149454, MGC 149453 TTGGGGTACAGACGAAA protein (LOC57228), transcript AGATGGAGAGTGACTTG CAGGAGTAGGTGTGAG
222 87262 41687677 5478059 LOC57228 NM 001031628 variant 1 , mRNA ILMN 1793049 Homo sapiens coroπin, actin
CATGGCCGCCCTACGGAAAATCCCATCCACAGA
KIAA0925, CLIPINC binding protein, 2B GGCCAGGGCTACCCAAG
778527 207 0476 324 3018 CORO2B NM 006091 (CORO2B), mRNA
Homo sapiens AXL receptor ACATTCAAAGCACTGATG
GGGATGGACGATCTCCCACCTTTCGGGCCATGT
UFO tyrosine kinase (AXL), TAGGAGATACACGGTAC TGCCCCCGTGAGCCAAT transcript variant 1 , mRNA TTGGAGCAGTCAGCC
2746581 3657231 40998145 AXL NM 021913 ILMN 1788931
Homo sapiens polymerase
RPAC1, RPA5, RPA39, RP3- (RNA) I polypeptide C, 3OkDa GGTTCTGACTGACCCACCCTACAGGACTGCTGA 337H44, RPA40 (POLR1 C), transcript variant ACAGAGAGCCCAGTGTG
486 32263 63680176 721 631 P0LR1C NM 203290 1 , mRNA
Homo sapiens glutamic- oxaloacetic transaminase 1 ,
GATCAAGTTGTCTGAAGGAGCCAAAGTGTGAAT
GIG18 soluble (aspartate GTGGGTGTCGGCTGCGG aminotransferase 1 ) (GOT1 ),
13904392 1508531 15330892 GOT1 NM 002079 mRNA
Homo sapiens nuclear TCACTGGGGACCACGAT
AGAAGGAGGGTTTCTGGCTGTGGTTCTAAATGG
CIA, bA465L106 receptor coactivator 5 GGGCATTCAGCCTGGTG AGCCCCAGGAAGCTGCC (NCOA5), mRNA TGTGGAATAATAGTGC
26906427 35995593 38002264 NCOA5 NM 020967 ILMN 1755769
Homo sapiens proteasome
MIP224, MGC23214, TBP7, (prosome, macropain) 26S GCAGCAAGAGCTGGAGTTCCTGGAGGTGCAGGA MGC13687, S6, MGC8570 subunit, ATPase, 4 (PSMC4), GGAATACATCAAAGATG transcript variant 1 , mRNA
5059643 864 48096 95508093 PSMC4 NM 006503
Homo sapiens regulator of G- TAGTGCCCTGACTAGGG
CCAGCAAGCTCGGTTTGAATACGTCACTTACCAG
ZGAP1. RGSZ1 protein signaling 20 (RGS20), GGAGGATTTGGATGTGC TGCCATTGCAGGACCC transcript variant 1 , mRNA TGCATTTCAAGCCGTG
92 135735 37657263 49621844 RGS20 NM 170587 ILMN 1682694
Homo sapiens IMP3, U3 small
GTCAGAATCACAAAGACA
BRMS2, MRPS4, C15orf12, nucleolar ribonucleoprotein, CTGGAAATCCCCACGCCCTGTTTCCCTTTATCGT GAGTGGTGGTTGGCAGG FLJ10968, DKFZp586L0118 homolog (yeast) (IMP3), CTTGTGGTTGGACTGG GGCTGCAGGAAGGGG mRNA
2072 5977 3161 0059 3450 331 IMP3 NM_018285 ILMN_1717064
Homo sapiens ring finger CCGCAGCTCTCATCATTGTGATGTGTAGCATGTC
RES4-26, SNURF
192 82262 2587101 2724226 RNF4 NM 002938 protein 4 (RNF4), mRNA TGCCCTCTGACTGGAC
pOS + no GFs
Synonyms Probe_Sequence Probe_Sβquence_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens phosphatidylinositol glycan TTTCTCCTCCACCCATCG
GTGGGAGCCGTACTCTTTGCCCTTCTGCTGATG
GPI2, MGC2049 anchor biosynthesis, class C AAACCAGCCACCCCTTC TCTATCTCATGTCTGTG (PIGC), transcript variant 1, CCTGTGCCACCAAGA
5462143 7162893 75445593 PIGC NM 153747 mRNA ILMN 1769721
DUSP13A, TMDP, SKRP4, Homo sapiens dual specificity
AGAGTCCTGCCCCTGCACCCACTCCCCCATTCC BEDP, MDSP, FLJ32450, phosphatase 13 (DUSP13), CGGCCCCAGGCCATGCC DUSP13B transcript variant 6, mRNA
7 894367 59 186882 8563135 DUSP13 NM 016364
Homo sapiens testis
GATCTCGGCTCACTGCAACCTCCGCCTCCTGTG
TGC1. TSGA3 expressed 11 (TEX11), TTCAAGCGATTCTTCTG
9466388 5675773 86 15837 TEX11 NM 001003811 transcript variant 1 , mRNA
Homo sapiens histidine triad CTGCGTGAGCAGACACC
GGATGACCGGTGCCTTGCTTTCCATGACATTTCC
PRKCNH1. HINT, PKCI-1 nucleotide binding protein 1 TTCACAGCTTCCTCGCTG CCTCAAGCACCAACAC (HINT1), mRNA CTGTCACCTGCACTA
12712 639 26651 996 31077 914 HINT1 NM 005340 ILMN 1812976
Tu^ , o GGAAACCTTCCTTAGAGT
Homo sapiens THO complex 3 -„- „„ „„„ CGTGGCACCCCAAAAGGCCTCTGCTGGCATTTG
TEX1. MGC5469 -um, mPMΛ CCTGTTGCTCAGTGTGG
(THOC3), mRNA TCCATCAGACGGTAG CCTGTGATGACAAAGAC
15689345 614 5143 823 3059 THOC3 NM 032361 ILMN 1737312
Homo sapiens Meis homeobox
TCGAACTCCAGCTTCAAGAATGTGTTTTCATGCC
MGC2820, MRG1, HsT18361 2 (MEIS2), transcript variant g, CGGCCTTTGTTCCTCC
50309315 369 07678 55596844 MEIS2 NM 172315 mRNA
Homo sapiens RD RNA
ACATGGCCAGTGCCTGTTCCCCACTCCCTTGCC
RDP, NELF-E, D6S45, RD binding protein (RDBP), CCAAAAGGATCTGGAAC
194 93929 298 32263 325 14343 RDBP NM 002904 mRNA
Homo sapiens ATP-binding cassette, sub-family F
GCAGTGAI I I I IATCCAA
DKFZp586K1823, ABC28, M- (GCN20), member 2 (ABCF2), CCTGGAGACATCCTGGCTTACAAGGAGCACCTC TCTTGTTTCCAAAAACCA ABC1, HUSSY-18, EST133090 nuclear gene encoding AAGTCCAAGCTGGTGGA TGTCTCCCAGGGCC mitochondrial protein, transcript variant 2, mRNA
63243933 1600 8226 19546892 ABCF2 NM 005692 ILMN 1756942
Homo sapiens serine
MGC 15229, MGC24556, hydroxymβthyltransferase 1 CCAGGCTTTCCTGCTCCACCTGAGATAACCAACT SHMT, CSHMT (soluble) (SHMT1), transcript CCCTCCCGTAATCAGG
79 105606 177 00595 21350179 SHMT1 NM 004169 variant 1 , mRNA
Homo sapiens calcium TACGTGTTGAGCGTGGC
TGCCTGGCTGTCTCCTTGACCCGCCTCCTAGAT
SCAN-1, SHAPY activated nucleotidase 1 CTACGTGAGCCAACAAG CATTGTCCTTGATGTCC (CANT1), mRNA AAGCAGGGGCCTCTGA
57804346 952 7726 1057 781 CANT1 NM 138793 ILMN 1756573
Homo sapiens asparagine- linked glycosylation 8 homolog TTTGGAAAGCAGGGTTC
CAATTCTCCCAATGAGCCTTTTGTCTGTGGGAAA
MGC2840 (S cerevisiae, alpha-1,3- CTCTGCCTGCTAACAAG AGCAGGAGACGCTTCG glucosyltransferase) (ALG8), CCCACGTGGACCAGTC transcript variant 2, mRNA
5964768 1081 3601 1203581 ALG8 NM 001007027 ILMN 1715426
pOS ♦ no GFs
Synonyms Probβ_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
HNRNPI, PTB-T, PTB3, PTB-1 , Homo saP,eπs polypyrimidine TGAGACCAAGGCCAGCA MGC8461, HNRPI, HNRNP-I, tract bmdiπg protein 1 TCAATTCCAGACATCTTC GAAACTCCTCCCTTGTCTAGCCCTGTGTTCGCTG PTB2, MGC10830, PTB, PTB4, (PTBP1), transcript variant 1, TGGACGCTGTAGAGGC
ATGTTCCTAATAGGC pPTB mRNA
5861 831 7272 006 76669395 PTBP1 NM_002819 ILMN 1738346
Homo sapiens chromosome CGAGAGCTGGAGAGAAG
CCCCCCTAAGGAAAATGTGCAGTTAATGAGCTAC
FLJ 10587 17 open reading frame 71 AAGGTTTCCCAGTGGGC AAGGTGCTCCGTGGGG (C17orf71), mRNA TTGAAGCTTGCTGTGC
7677359 11535179 123280945 C17ORF71 NM_018149 ILMN 1785444
Homo sapiens transmembrane
RP13-360B22 2, bB360B22 3, GACCATGACCCACGGGAAGCTGGTCATCCTGTT protein 164 (TMEM164), FLJ22679, FU20173 CTCATACATGGCTGGGC
10 132967 63725624 9273096 TMEM164 NM_032227 mRNA
Homo sapiens synovial sarcoma translocation gene on ACTGTGTGCTCCTTCCTATCAGTTTGTAAATGTG
KIAA-ISO chromosome 18-lιke 2 GTCCCCCTGACTGCTG
17446643 30124644 3409 1143 SS18L2 NM_016305 (SS18L2), mRNA
Homo sapiens cell division CCTTGGCCTAAAGCCTT
TCTTTGTGTCCCCCACTGTAGAGGACGGTGAGC
MGC19517, FLJ20764, HEPP cycle associated 4 (CDCA4), GGTTCTCAAACTGGGTT CGCAGCTGCATCAACCT transcript variant 13, mRNA CCTTGGGACCTCCGGG
10069855 271 86844 35424347 CDCA4 NM_017955 ILMN 1806937 βlF4AIII, MGC10862, Homo sapiens eukaryotic
CAGCAGATCAGTGGGATGAGGGAGACTGTTCAC hNMP265, NUK-34, KIAA0111, translation initiation factor 4A1 CTGCTGTGTACTCCTGT DDX48 isoform 3 (EIF4A3), mRNA
1692456 2121 6892 2237 7476 EIF4A3 NM_014740
Homo sapiens cleavage GCATCCCATTGCCAGCC
MGC75122, MGC43001, stimulation factor, 3 pre-RNA, πGCTGTCAGATTCAAAA AGCACGGAAGACTTATGAACGCCTTGTTGCCCA MGC117398, CSTF-77 submit 3, 77kDa (CSTK), πGCTTTTTCTAGAG GTTCCCCAGTTCTGGCA transcript variant 2, mRNA
4408976 1191 1018 1492 4559 CSTF3 NM_001033505 ILMN 1765620
Homo sapiens dihydrouridine AGAACATAAATGGCCTCC
GAGAAGACCCGGCGCTTTCTGCTCGAGTGGCTG
FLJ13896, DUS3 synthase 3-lιkθ (S cerevisiae) TGCCAGCTCCGGCGTCT TCCTTCCTGTGCCGGTA (DUS3L), mRNA CTCTGTGGTCTGCCT
279 85178 40835596 44706012 DUS3L NM_020175 ILMN 1760335
Homo sapiens zinc finger
KOX28, FLJ20562, ATGAGTGTTATACCCTAAGAGTCTGAGGAGTGTG protein 30 (ZNF30), transcript DKFZp686N19164 GGAAGTGCTTCGTGTG
59621773 11745595 13648096 ZNF30 NM_001099437 variant 2, mRNA o.rw . GGCATGCTTTATCGTGT Homo sapiens SAPK substrate GGCTTTCCCCTCTTCAAA CAGGACTCGTGCCTTCTGCTGTTCTCATTGTGG
2B28 protein 1 (LOC51035), mRNA TATTAATGGCCAGGT CCAAGAAATGTCCCAGC
18768394 5780539 7408 589 LOC51035 NM_015853 ILMN 1761963
Homo sapiens FAST kinase TGTCCCACTTCCTCTATG
CCAGAAGGGTTATTTTTCCAACCACACCTATTCC
KIAA0971 domains 2 (FASTKD2), TCCCTTTCCTTGGTGTCT CTCTAGTGCCCAGATA mRNA GTGTCTGTGGGGCC
93 12271 162 4643 18481429 FASTKD2 NM_014929 ILMN 1748090
Homo sapiens transmembrane
GGAATCAGCTCTCGCACTGCCCATCTTTGCAGTT
DKFZp762O076 protein 55A (TMEM55A),
TTGAAAAAGAAATTGC
18651428 282 13928 3007726 TMEM55A NM_018710 mRNA
Homo sapiens ubiquitin specific peptidase 21 AGGTGGCATCCAGCGAGGGCTACGTGCTGTTCT
MGC3394, USP16, USP23
(USP21 ), transcript variant 1 , ACCAACTGATGCAGGAG
12082678 48378094 631 4143 USP21 NM 012475 mRNA
pOS + no GFs
Synonyms Probe Sequencβ Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens translocase of inner mitochondrial membrane
AGAGTGCCAGAGAACCG 17 homolog B (yeast)
TIM17B, JM3, DXS9822 TTGCTTTTCCGAGTTGCT GTCCCCTTTTTCTCTCTCAGGGCACCCCAGCCC (TIMM17B), nuclear gene CACACTCACATGTACGA CTTCTTCCAGGCTCC encoding mitochondrial protein, mRNA
17522678 211 59761 21964761 TIMM17B NM 005834 ILMN 1655011
LHR, CDW44, ECMR-III,
Homo sapiens CD44 molecule CCTCGTCAGCCCCCGCT MGC10468, MDU2, CSPG8, (Indian blood group) (CD44), CAGGCCACGTTCATCAG GCCACTCCAGGACAAGGTTCAAAATGGTTACAAC Pgp1, IN, MUTCH-I, MIC4, AGCCTCTACCTGTCGC transcript variant 5, mRNA CCCAAGCGAAGATTTT MDU3, MC56, HCELL
16560476 3360 1392 3843431 CD44 NM 001001392 ILMN 1768020
SIZ2, MIZ1, miz, ZMIZ4, PIASX- Homo sapiens protein inhibitor
GCCTGGCTATGCACCACCGCCTAAAAATGGGAT ALPHA, MGC102682, PIASX- of activated STAT, 2 (PIAS2), TGAACAGAAGCGCCCTG BETA transcript variant beta, mRNA
31 311932 134 10603 159 70595 PIAS2 NM 004671
Homo sapiens processing of precursor 5, πbonuclease CTCCTGCTGTGAGAACA ACCTCTGCTCCCCAC
HSPC004, RPP20, RPP2 P/MRP subuπit (S cerevisiae) AGTGGATGTCCCTCTCC GCAGAAGCAATGGAGTGA ACAGCTGGCTACACTGC
(POP5), transcript variant 3, CCGCCCTCCTGCTGAA mRNA
34953513 659881 74561426 POP5 NM 198202 ILMN 1802872
Homo sapiens similar to C367G8 3 (novel protein rjd10, C367G83, RPL2B, CACAAGATGGCGCTGAAAGCAAAGAAGGAAGCT similar to RPL23A (60S RPL23AL CCTGCCTCTCCTGAAGC nbosomal protein L23A))
1842976 29447678 32328928 LOC441743 NM 001045548 (LOC441743), mRNA Homo sapiens LSM2 homolog,
G7b, snRNP, C6orf28, U6 small nuclear RNA CCAGGGCAGCATGTGATTCATTTGGGGATGGAA YBL026W associated (S cerevisiae) GGAATCTGTCCCGCATC
16683059 2884 0225 3275 1895 LSM2 NM 021177 (LSM2), mRNA
Exo70p, 2-5-3p, Homo sapiens exocyst DKFZp686J04253, FLJ40965, complex component 7 CCCAGCATGGTCTAGATGGGAAAAAGGGGGGCT EXO70, YJL085W, FLJ46415, (EXOC7), transcript variant 1, CTAACCTCATTCCTCTG EXOC1 , EX070 mRNA
16089306 9669799 131 63928 EXOC7 NM 001013839
Homo sapiens neurogranin
GATCCGGGGCGAGATGAAGGGAAGAGGGTTGT
RC3, hπg (protein kinase C substrate, TTTGGTTTCGGACGACCC
2894812 12726845 181 77261 NRGN NM 006176 RC3) (NRGN), mRNA
KRTAP18-2, KAP102, KAP18- Homo sapiens keratin
CCTCTGTGTCCCTCCTCTGCCGCCCCGTGTGCT 2, KRTAP102, KRTAP182, associated protein 10-2 CCCGCCCAGCCTCCTGC
9 176077 44 750954 59422947 KRTAP10-2 KAP182 NM 198693 (KRTAP10-2), mRNA Homo sapiens cerebral
AGCGCCTCAAGGGGGCC
MGC74868, MGC4067, cavernous malformation 2 GGCCGCGGGAGCCGCACGCGGCGATATGGAAG TCGGAGAACGAGGAAGA MGC4607, C7orf22, PP10187 (CCM2), transcript variant 2, AGGAGGGCAAGAAGGGCA GGACGACGACTACAAT
97 12001 131 84344 141 86845 CCM2 NM 031443 mRNA ILMN 1680904
Homo sapiens round GGCGAAGCCCAGGAGAC
FLJ45813, FLJ42526, GTGCCTGTCCATAACTGTGAAGTATTAAGCACTT spermatid basic protein 1-lιke CACCGAGGAGTTTAATC MGC71764 AGGGCCAGATGCACTG (RSBN1 L)1 mRNA GAGAGATGTTCTGGAG
6925007 19079346 227 14761 RSBN1L NM 198467 ILMN 1658743
pOS + no GFs
Synonyms Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe.Sequence Probe Id
Homo sapiens proline-nch
GTTTGGTCAAGGGGTAGGTGCAACCCAATGGAC
MGC99541, FLJ20312 nuclear receptor coactivator 2 CACTTATGCAAAAGATG (PNRC2), mRNA
9758142 1063 1143 10756226 PNRC2 NM 017761
Homo sapiens cell cycle
ACATGCCCCGAGTGCGG
M11S1 , p137GPI, GPIP137, associated protein 1 CGGGGCCCTGCCAATGGATTCAGAGGAGGATAT
AAGAGGATTTACAAGGA GPIAP1 , capπn-1 (CAPRIN1), transcript variant GATGGTTACCGCCCTTC GCTATGTGAGTGCCGG
716 98926 2313 3892 2875 356 CAPRIN1 NM 005898 1, mRNA ILMN 1675501
Homo sapiens zinc finger GCACCACTGCGTCAATT
CCCAGCTGTGGACCACTGCCTGAAAGGTTTGTA
OKFZp761N202 protein 207 (ZNF207), CCCCAGGCTCCTATTTCT CAGATGCATGCCACAGT transcript variant 2, mRNA GTCACTGCCAAGTTG
1257 1685 36254143 4412 081 ZNF207 NM 001032293 ILMN 1737503
Homo sapiens electron- transfer-flavoprotein, alpha
GGGAACCCCTTGTGAGC polypeptide (glutanc aciduria TGGTGCTTCCCGTGCTGCTGTTGATGCTGGCTT
GA2, MADD, EMA ATGCTCAGTATCATTGTG M) (ETFA), nuclear gene TGTTCCCAATGACATGC GAGAACCAAGAGGGC encoding mitochondrial protein, mRNA
25120642 8593535 10802214 ETFA NM 000126 ILMN 1727041
Homo sapiens vacuolar
AGCAGCAGGAAGTGGTGTTGTGGCGGAAGGGT
Pβpβb, MGC10485 protein sorting 26 homolog B GACATCGTACGGAAGAGC (S pombe) (VPS26B), mRNA
341 7351 482 9726 522 15594 VPS26B NM_052875
MGC150422, BK126B4 3, Homo sapiens CGI-96 protein TCTTGCCTCCACACCCTCCTCTCCAGGACCCTG
1039 1226 1771 2476 19439392 CGI-96 MGC150423 NM 015703 (CGI-96), mRNA GATGAATCCGTTCTGTG
Homo sapiens leucine CCTGCTAGCCAGCCCCA
TYW4, PPM2, MGC9534, GCTGAAGACAGTGGCCATGCAGTCCGAGAGGAG carboxyl methyltransferase 2 GCCCTTTTCAGCCCAAG KIAA0547 TAGTGGTCTGCCTCTAA (LCMT2), mRNA GAGACATGGAAGAAAA
291 9226 46037677 51440594 LCMT2 NM 014793 ILMN 1687782
Homo sapiens nucleolar ACTGTTGAGCAGGCCTC
RARG-1, dJ223E52, GTTCCTGTCTCTTGCCAACAAGAGGTTACCAGTG protein 7, 27kDa (N0L7), TCTGCCTGTGGCCTTCC MGC71933, C6orf90 AAAAGAGCTGCTGTCC mRNA GGCCGGTTTCCAGACG
3641 4727 4454 8975 47133643 N0L7 NM 016167 ILMN 1808066
Homo sapiens centrosomal
GGAAGAGGAGGAACTGAGGTCTCATCACATTCT
MGC78416, FLJ13386 protein 63kDa (CEP63), AGAGCGCTTGGATGCCC
42897263 4696601 4837226 CEP63 NM 025180 transcript variant 1 , mRNA
PREDICTED Homo sapiens AGACGGGCAGCGGCACC
GTCACCACTAGTCAATGACTGCTTTTGCCCTGTC FLJ35409 protein (FLJ35409), ATCCTCACACCTCTGCAT ACTGTCCATAGCCATG misc RNA TCTGATAGAAGTCTG
3925047 237 97263 3344268 FLJ35409 XR 017838 ILMN 1672908
Homo sapiens family with
AGTCACTCACCCACTGTGTTTCTGGTGCCAAGG
FU10491, FLJ10156 sequence similarity 64, CTCTTGAGGGCCCCACT member A (FAM64A), mRNA
307 5351 64223096 781 16016 FAM64A NM 019013
Homo sapiens paired-like
GGCCCGCGCCCCTGTTTACAGCGTCCCTGTGTA
POTX, PTX1, BFT homeodomain transcription TGTTGGACTGACTGTAA
442 99762 1175 356 1469 1393 PITX1 NM 002653 factor 1 (PITX1), mRNA
Homo sapiens testis TATTGCTGATTGTACTGG
FLJ13935, SIG11. ZSIG11. CTCTTGCTAAGCCTTCTCCTCACTGCCCTTTAGG expressed 264 (TEX264), TTGTTGCTTGTTGACTGT DKFZp451H0417 CTCCCAGGGCCAGAGG mRNA ACTATTCAGATGGC
26531012 32469763 34044763 TEX264 NM 015926 ILMN 1684563
pOS + no GFe
Synonyms Probθ_Sequβncβ Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens proteasome
MIP224, MGC23214, TBP7, (prosome, macropain) 26S CACAGAGGCCGGCTTGGTCACTATGGAGGAGAT MGC 13687, S6, MGC8570 subunit, ATPase, 4 (PSMC4), AGGCATCTTGGTGGAGA transcript variant 1 , mRNA
9704143 2483306 31062227 PSMC4 NM 006503
Homo sapiens succinate
CCTGCCCCTCTGTTTCC dehydrogenase complex, CCTGGCCAAGCTGCAGGACCCATTCTCTCTATAC
SDHIP, SDH, SDH1. PGL4, IP GATGAGGTGTACGGATG subunit B1 iron sulfur (Ip) CGCTGCCACACCATCA AGTGACCTGCACTAAG
23785977 3701 0728 4118606 SDHB NM 003000 (SDHB), mRNA ILMNJ 728626 Homo sapiens cirrhosis,
FLJ14728, TEX292, KIAA1988, ACACTCGTGGCAGTAGAACGGCCTCTGGATGAC autosomal recessive 1A NAIC, CIRHIN ATCATTGCTCAGCTCCC
1167956 14559644 15385227 CIRH1A NM 032830 (cιrhιπ) (CIRH1A), mRNA
Homo sapiens thymidine TACTGAAGTCCCTTTGTG
TGACATCAGCCTGCTTCTTCCCCTCTGCGGCTTT
TK2 kinase 1, soluble (TK1), CCAGTGGATCCTGGAGG CACTGCTGAGTTTCTG mRNA GCCTGGGGCTGGGCA
957 07263 1494 9392 1727 8643 TK1 NM 003258 ILMN 1807249
Homo sapiens programmed CCAGGGACGCCTTGGAA
GCAAGAGCATTGACTGGGGCATCCTGGCTGTCT
RP8, MGC12347, ZMYND7 cell death 2 (PDCD2), GAGTCACTCAAGCTGAA TCACCTGTGCTGAGAGC transcript variant 1 , mRNA AAACTGGAGTTGCAGC
9953893 1845 756 21298809 PDCD2 NM 002598 ILMN 1684570
Homo sapiens G protein
GTTCCCGCCTCAGTCAGGTGCAGACAAGTGGGC
COPS1, CSN1, MGC71287 pathway suppressor 1 (GPS1),
GGTGTCCATTAAAGAGC transcript variant 2, mRNA
934 8893 1027 2767 10624476 GPS1 NM 004127
Homo sapiens UDP-galactose- ACCATGATGCTGGATGG
GGCCAAGGGCTCCACTGACCAGGAGGCCGAGG 4-epιmerase (GALE), AAGCTACAGTGAGTCTG TCTCTAACTCTTATCTTC transcript variant 1 , mRNA AGGCCAACAGCCTGGC
89 19764 14806429 161 96011 GALE NM_000403 ILMN 1676870
Homo sapiens calmodulin GACTCGGCCAGCCCCCT
ACCCGACTCCGCATGTTTGCGTCTGTTTCCTCCC
KIAA0909 binding transcription activator CTTCCCCGTGTGTGTCAT TCTCTGGCCCTGTCTT 2 (CAMTA2), mRNA AGTTGTGCCATTCTT
53229553 191 06845 25247263 CAMTA2 NM 015099 ILMN 1812062
Homo sapiens tRNA methyltransferase 12 homolog GAAGGAGGGCCAAGATGGAAACAGAGAGACCAG
FLJ20772, TRM12, TYW2 (S cerevιsιae) (TRMT12), TGAGGAGGCTTCTGTGG
259 71844 28681427 298 54346 TRMT12 NM 017956 mRNA
Homo sapiens ubiquitin
ACATGTCCTGGGTGACA specific peptidase 21 CGGAGAATGCCCCAGTGTGTGACCGATGTCGGC
MGC3394, USP16, USP23 TGGGATGTGACTTTCGG (USP21), transcript variant 1, AGAAAACTCGAAGTACC GTGTCGGGGCAGCATG
187 31429 47684763 5938976 USP21 NM_012475 mRNA ILMN 1717702
Homo sapiens proteasome
MGC32631 HC8, PSC3, (prosome, macropain) subunit, TGCAGACAGAGTGGCCATGTATGTGCATGCATA MGC 12306 alpha type, 3 (PSMA3), TACACTCTACAGTGCTG transcript variant 2, mRNA
14909768 21502852 23322144 PSMA3 NMJI52132
Homo sapiens chaperonin
GCTGAGATGGCTGTGCC
CCTG, TRIC5, TCP-1 -gamma, containing TCP1, subunit 3 ACCATCCGTCTACTTACCTCCCTTCGGGCCAAGC
CCAACTCCCATTCACCCA PIG48, CCT-gamma (gamma) (CCT3), transcript ACACCCAGGAGAACTG CCATGGACCCAATAA
1827 8976 37854893 4519889 CCT3 NM_005998 variant 1 , mRNA ILMN 1727723
pOS + no GFs
Probe_SequencβJ Raw XS pOS + 6 GFs Raw Raw Common Synonyms Genbank Description Probβ.Sβquβncβ Probe Id
RP11-3J10 8, RRP40,
Homo sapiens exosome
MGC723, hRrp40p, MGC15120, GAATGGGTGTCATTGGACAGGATGGTCTGCTTT component 3 (EXOSC3), p10, Rrp40p, bA3J107, CGI- transcript variant 1 , mRNA TTAAAGTGACTCTGGGC
41606427 770 131 891 2226 EXOSC3 102 NM_016042
Homo sapiens aldo-keto reductase family 1 , member
ALR, ALDR1. MGC1380, A1 (aldehyde reductase) ATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTG MGC12529 ATCTGCATCCCCAAAAG (AKR1A1), transcript variant 1,
1211 5768 28997727 3621 2559 AKR1A1 NM 006066 mRNA
Homo sapiens mitochondrial nbosomal protein S7
RP-S7, RPMS7, MRP-S, MRP- GCCCTCTGCCGCAAGAAACAGTGTGAGCTACTG (MRPS7), nuclear gene S7 CCACGCTGAAAACTACC encoding mitochondrial protein, mRNA
542 3726 75384766 807 8726 MRPS7 NM 015971
Homo sapiens mitochondrial nbosomal protein L13 TGGCATCGTCCCTGAAA
CTGCTACAGTTCAGCACCTGTTTTATGTGCCGAA
L13mt, L13, RPML13, RPL13 (MRPL13), nuclear gene CGTGGATTGATGGCCCC TCACTGTGGGGAAAGG encoding mitochondrial AAAGACACATCAGTGG protein, mRNA
741 2726 1041 781 11359727 MRPL13 NM 014078 ILMN 1695576
Homo sapiens TatD DNase TGACTGCTTCTAGAGCT
MGC126819, KIAA0218, CTGCAGGTGAAACCAACCAGCCCTGTGTTAGAG domain containing 2 GGGAGGATCTGCAGACT MGC126825 GAGGAAAAGCGGAGATG (TATDN2), mRNA TTCACGGATTCATGGA
29003094 3067143 31089343 TATDN2 NM 014760 ILMN 1682553
Homo sapiens centromere CATCTGGAGTTCTCAAAG
GGGCCCAGAGTCCAGCCGTCCAGCTGCTCCTTT protein B, 8OkDa (CENPB), ACCTGGGGCTGCTGTGA CCCAGTTTGATTTCAAT mRNA AGCTGGAACTGCGGG
2342 2644 3571 7476 3968 5645 CENPB NM 001810 ILMN 1671316
Homo sapiens BCL2-lιke 1 bcl-xL, BCLX, (BCL2L1 ), nuclear gene GCAGTGTGAGAACTGAA
AGCGTGTCTGTATTTATGTGTGAGGAGCTGCTG
DKFZp781P2092, BCL-XL/S, encoding mitochondrial GTATTTCTGATCACTCTC GCTTGCAGTGCGCGTGC BcI-X, bcl-xS, BCL2L protein, transcript variant 1 , AGACTGTCCTCCGTG
2929731 7191 539 9034797 BCL2L1 NM 138578 mRNA ILMN_1792472
Homo sapiens COMM domain GCAAGCAGTAAT AAAGTC
FLJ13008, HT002, HCARG, ATTCAGATCCGGCTTGGACAGGCACCTGAGATG containing 5 (COMMD5), TCCCTTAAAATGCACCCT MGC72046 GTGCCAAAGTGCAGCTG transcript variant 1 , mRNA CCTTCCACCTGGCC
5129143 552 23926 5609518 COMMD5 NM 014066 ILMN 1765146
Homo sapiens trafficking TGCCCAGGGGAGGGAGT
TGGGAAGCCACCCAGGTCTCATTCCTCCCTGCT
BET3 protein particle complex 3 GTGGACAGTATCTGGAA GTTGGAGGCAACATCTC (TRAPPC3), mRNA GTTCTGGGATTCAGGT
998 9226 25658809 32377808 TRAPPC3 NM 014408 ILMN 1706609
Homo sapiens actin related AGTGAGGCTGGAGGTGG
GAGCCCATCAGCTGCCACGCCTGGAACAAGGAC
P41-ARC, ARC41, p40-ARC protein 2/3 complex, subunit CAGCTTCACAGAACTGG CGCACCCAGATTGCCAT 1B, 41kDa (ARPC1B), mRNA AGAACCAGGCCAAGTC
8799393 1397 3767 15655184 ARPC1B NM 005720 ILMN 1777261
Homo sapiens family with
CTCCTGCATGGCAAAACTGCCTATTCTGCTATTT
L1, DKF2p686B04128, BM-009 sequence similarity 49, AAAAACCCTCAATGAC member B (FAM49B), mRNA
13395178 300 37677 367 74347 FAM49B NM 016623
pOS + no GFs
Synonyms Probe Sβquencβ Probe Sθquencβ l Raw XS pOS + 6 GFs Raw Raw Common Gβnbank Description Probe Id
Homo sapiens prickle homolog
OEBT, MGC120398, OBTP, GGCACCTCAGCCAGGGGTGTAGCCAAGTAGACA 4 (Drosophila) (PRICKLE4), C6orf49 AATGGAATCCTGTGCTG
16982476 2644 5645 29827642 PRICKLE4 NM 013397 mRNA
Homo sapiens high mobility CGCAGTAATTCTCATGTC
MGC12816, MGC4854, HMG- CCCCCCAAGGTTCTGGTTCCAI I I I I CCTCTGTT group AT-hook 1 (HMGA1), CCCATAAGCAGAGCTGT R, MGC4242, HMGIY CACAAACTACCTCTGG transcript variant 1 , mRNA CACAGTGTGCACTAC
1811 381 9582 072 15217 964 HMGA1 NM 145899 ILMN 1708147
Homo sapiens translocase of inner mitochondrial membrane CCTGTGTGAGGGCACAA
PRO1197, TIMM23B, TCCTCCCCCATGAACTAGAAAACCACTTACTCCC 23 homolog (yeast) (TIMM23), CCAGGCCACGGGACCTT MGC22767, TIM23 AGAATTCAGGTCGTGC nuclear gene encoding CTATCCTCTGTATTTG mitochondrial protein, mRNA
5528 731 63968477 6640664 TIMM23 NM 006327 ILMN 1683462
Homo sapiens lysosomal- associated membrane protein ACCTTGATGGTAACGCTCTATCTGGTTTTGGGTG
LAMPB, CD107b, LAMP-2C 2 (LAMP2), transcript variant I I I I I CATGTTTTAGC LAMP2B, mRNA
18660059 20787559 2134 5393 LAMP2 NM 013995
Homo sapiens c-Maf-inducing AGTTGCCTCCTTCAAAGA
TCTTTCCCCCCTCCGGTCCCATACTTCACAGCAC
KIAA1694 protein (CMIP), transcript AGCATGCATGGTCCTTG TCTGGTGCGGGAAGAA variant Tc-mιp, mRNA CAGGTCACTGTGCCC
3557726 5844393 66940594 CMIP NM 030629 ILMN 1788764
Homo sapiens chromosome
CTGGAAGAATATTCGAGGACCCAGGCCTTGGGA
HSPC203 14 open reading frame 112 AGATCCTGACCTCCTCC
1017 0226 1381 4768 1497 106 C14ORF112 NM 016468 (C14orf112), mRNA Homo sapiens TAF1 O RNA polymerase II, TATA box
GGACTTGACCCCTGCCCTCAGCGAGTATGGCAT
TAF2H, TAF2A, TAFII30 binding protein (TBP)- CAATGTGAAGAAGCCGC assoαated factor, 3OkDa
17082059 5548764 7530789 TAF10 NM 006284 (TAF10), mRNA Homo sapiens DEP domain
GCAAGAGGCTGTACCTAAAATTCCTCAACCTAAG dJ85M64 containing 7 (DEPDC7), AGGCAGTCCACCATGG
35913116 63528175 71 57934 DEPDC7 NM 001077242 transcript variant 1 , mRNA Homo sapiens proteasome
AAGTTGTTCCCTGGCCG p44S10, KIAA0107, S10, SGA- (prosome, macropain) 26S GGTGTGGAATTCATTGATCAGGAACTGTCCAGG GGAGCGTTTGCTTTCGC 113M subuπit, non-ATPasβ, 6 TTTATTGCTGCCGGGAG CTGTAATCCCAACACT
3695 531 4974 5645 54190645 PSMD6 NM 014814 (PSMD6), mRNA ILMN 1653180
Homo sapiens ATP-binding
DKFZp586K1823, ABC28, cassette, sub-family F TTRrARGTRAAAPrAAr
(GCN20), member 2 «ABCF2), ^^CCAAC CACCTGTAATCCGACTGTAAGCTCATCACCTTGG HUSSY-18, EST133090, M- ABC1 nuclear gene encoding GAGGCCACTGTAGGAG mitochondrial protein, transcript variant 1 , mRNA
14953094 184 55594 19764346 ABCF2 NM 007189 ILMN 1734138
Homo sapiens acidic (leuciπe-
C15orf1, PP32, PHAPI, πch) nuclear phosphoprotein GGGGTCAGAAGCGAAAACGAGAACCTGAAGATG MGC150373, PHAP1, I1PP2A, 32 family, member A AGGGAGAAGATGATGAC LANP, MAPM, MGC119787 (ANP32A), mRNA
6366634 11457262 13508095 ANP32A NM 006305
pOS + no GFs
Synonyms Probβ_Sequeπce Probβ_Sequencβ_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens de-etiolated TGGAGTTCCAGTGATCC
FLJ10103, MGC126157, GCTCTGTTAGTTCCAGCCTGCTATACCTCAGATG homolog 1 (Arabidopsis) CGGAGTCTGAACCGGCA MGC126156 GGAGAGAGCCAGAGAG (DET1), mRNA GTGAGAGTGGGGAAAG
14768095 168 86429 178 55594 DET1 NM 017996 ILMN 1681724
CENPU, KUP1. FLJ23468, Homo sapiens MLF1 TTGCTCTTCCGTTGCCCC
CAGTTCTGTGCACATACTTTTCAATACTCCCCGA CENP-50, CENP50, PBIP1, interacting protein (MLF1 IP), GTGGCTTCAGCTCATCTT CGGAAGAGCAAGGGTG U(SO)1 CENP-U NM 024629 mRNA TGGCAGGAAGGCGA
28 060312 7687431 1108413 MLF1IP CENP- ILMN 1720764
Homo sapiens bolA homolog 3 CCTCAACAGGCCCAGGG (E coll) (BOLA3), transcript AGGGAAGTGTGAGCGCC CATGGATTGCGGATATTTACCTCTGTCCCCAAAC GCTGACCACGCCCTGG variant 1 , mRNA TTGGTATGACTTAAAA
3022 8142 4676 356 5290 5645 BOLA3 NM 212552 ILMN 1708375
Homo sapiens KH domain containing, RNA binding, TCCATTTGAGATTCTGCACTCCATGAAAAGTTCA
Sam68, FLJ34027, p62 signal transduction associated CTTGGACGCTGGGGCC 1 (KHDRBS1), mRNA
4024 7227 47930557 50588975 KHDRBS1 NM 006559
Homo sapiens metallothionein CGCCTGATGTCGGGACAGCCCTGCTCCCAAGTA
MT1. MT1K, MGC 12386 1G (MTIG), mRNA CAAATAGAGTGACCCGT
12741104 554 1309 853 3185 MT1G NM 005950
Homo sapiens BRCA2 and CDKN1A interacting protein GGTTCACGGGGGCAAGTGACAGCCCTGGTTTCT
TOK-1 (BCCIP), transcript variant A, CTGAAGGCTGGACTAAT
11963095 25485596 313 9768 BCCIP NM 016567 mRNA
Homo sapiens barrier to AGAAAGGCACAGGACTC
D14S1460, BCRP1. BAF, GCTTCGGATGCCTTCGAGAGTGGTGCGACGCCT autointegration factor 1 GCTAAGTGTTCGCTACG MGC111161 TCTTGTGATGCTCTCTG (BANF1), mRNA CGGGGCTACCGGATCG
41537725 50389395 53547144 BANF1 NM 003860 ILMN 1766762
Homo sapiens zinc finger CATGTATCGGAACTTAGA
GAAGAAGGACAGCGTAGTGGCACACAAGGCAAA
PZF, FKSG11. ZNF757 protein 91 homolog (mouse) ACTGGTGGGCGCGGTG AAGCCACCCTGAGGTGC (ZFP91), mRNA GCTCTTGCCTGTAATC
41 88808 8587268 10483512 ZFP91 NM 053023 ILMN 1661519
LyGPR, DRY12, GPCR-Br, Homo sapiens G protein-
CTCAGCCCGACATCCAA
LERGU, MGC99678, GPR30, coupled estrogen receptor 1 GAGGCTGGTGACGTTCAGCCTTTGTCAATAAAC CAGGCGCCAAACTCACA
CEPR, CMKRL2, FEG-1, (GPER), transcript variant 3, CTGTCATGTGCGGATCC GAGCCCTTGTGCAGAT
30 141129 54211746 66 565834 GPER LERGU2 NM_001039966 mRNA ILMNJ 763207
Homo sapiens
TCAGCAGCTGTTTGGCCTAATTCTTAGCATTATT
MGC4980, SELD, SPS, SPS1 selenophosphate synthetase 1 TTGTCCTTTGCGCCAG (SEPHS1), mRNA
44900595 5088518 527 14343 SEPHS1 NM 012247
Homo sapiens chromosome X CTTTATGCAAAATGGCTC
GTGGATAGCATTTTGAAGGTGACCGTGATTCTGT open reading frame 39 CTGTGAGGGCTGCAAGC AGGAAGAGCTGTAATC
(CXorf39), mRNA TGGAGGGTGGTGCAG
82 160805 13031012 141 89761 CXORF39 NM 207318 ILMN 1784780
GTCCAGATGAGAGCAGA
Homo sapiens histone cluster
H3/C, H3FC, H3 1 GATACAGTGAGAAATTAT TGGGACTCTTCGAAGACACCAATCTGTGCGCTAT 1, H3c (HIST1H3C), mRNA TCACGCTAAACGCGTC GTGATCTGTGTGTTG
11 189314 51 7182 7605653 HIST1H3C NM 003531 ILMN 1742324
Homo sapiens sex comb on
GCACGAAGTCCCTCTGC midleg-hke 1 (Drosophila) ACCCGATCCTCAGCCGCACTCCGAGTCCAGTGC (SCML1,, transcript ^ I. ^S™*" ATCCCTCAGATTTCTCT
70712296 106 30179 10928928 SCML1 NM 001037540 ILMN 1751569
pOS + no GFs
Synonyms Probβ_Sequencβ Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Gβnbank Description Probe Id
Homo sapiens chromosome 1 CACTCTATGGGAAACTCT
TATACCTGCTCTATGTGGGTGCTGCATGCTAGGA
FLJ25078 open reading frame 74 TCAGCACCTACCTGCGC AAGTAGGGCTGGGGGC (C1orf74), mRNA cccccACACACCTCT
48944515 9838512 102 126785 C1ORF74 NM 152485 ILMN 1674759
Homo sapiens cell division cycle 42 (GTP binding protein, AGCCGAGGAGACCCCGCGCAGTGCTGCCAACG
CDC42HS, G25K 25kDa) (CDC42), transcript CCCCGGTGGAGAAGCTGA
21033928 64466016 676 57263 CDC42 NM 001039802 variant 3, mRNA Homo sapiens chromosome
TGCAGCAGGACTACATCGAACTCTGATGTGCCG FLJ21415 12 open reading frame 49 GATTGTGGCATGTCTGC
146 50595 164 78511 16724762 C12ORF49 NM 024738 (C12orf49), mRNA Homo sapiens antigen
CTTGCCCGGAGACCAAG identified by monoclonal CCTTAGGCAGGCACCTCCAACCACCACACACTC KIA, Kl-67 AAGGCGCGCGATGCGTG antibody Kι-67 (MKI67), CCTGCTGTTTTCCCTGC TATCATCGAGAAAGGA
23 136848 9347684 100 16429 MKI67 NM 002417 mRNA ILMN 1770885
ATCTCTCTTTGTCTTGAG
FU10414, KIAA0360, HSAL2, Homo sapiens sal-like 2 CAGCTCCAGGTGGCGTCCTCCCTGCCTCTCCGT GGGGCTGTTGAGTGGTC ZNF795, p150(Sal2) (Drosophila) (SALL2), mRNA CTTGTAATGAGTTGTAG GCGGACCTGGGCTCT
33740974 6494226 76868097 SALL2 NM 005407 ILMN 1663234
TSC22, TGFB1 I4, RP11- Homo sapiens TSC22 domain GGAAAGGGTTAAAGTGA
TCCCAATGGTGTAGACCAGTGGCGATGGATCTA 269C232, DKFZp686O19206, family, member 1 (TSC22D1), GGAAGGTGTACGTGAAG GGAGTTTACCAACTGAG MGC17597 transcript variant 2, mRNA GGTCTGGGGTTGCTGG
22961012 5597 581 65598477 TSC22D1 NM 006022 ILMN 1797801
GACCCGGAGTAGGGGG
Homo sapiens nucleopoπn GACTGTCCTGGCATCGAACTCTCCCTCTGTGTGT
MGC5585, p37, FLJ22618 GCTCGGGACCATGAGGA 37kDa (NUP37), mRNA AATTGGAGGAGACCAC
TGACCAGCAAAATTCAA
12324393 21368977 22285642 NUP37 NM 024057 ILMN 1790741
Homo sapiens mitochondrial ribosomal protein L35 (MRPL35), nuclear gene CAGCATGTCAGGCCAGGATTATTAGGGAGATTC encoding mitochondrial CTCGAAACTAGTGTGTG protein, transcript variant 1 ,
118 530945 20869762 21366428 MRPL35 NM 016622 mRNA
Homo sapiens oxidative stress CTGGTGGGATGGGTATG
CTCTCAGGCCCCACAACTTACTTCCTGCATTTTA
C8orf1, hT41 induced growth inhibitor family GGACCAGGTGGCCCAGG ACAAGATCCCCAAGGG member 2 (OSGIN2), mRNA AATGATTACTATCCCA
107 87272 13440594 13658928 OSGIN2 NM 004337 ILMN 1725199
Homo sapiens drebrin 1 GCGCTCCAATATCGTGG
AAAACATGGCAATAAATGGCTCGTGGGCTCTGG
DKFZp434D064, D0S117E (DBN1), transcript variant 1, ACCTGCTGTTTGTCAAAG CTCCCTGGGACCCCCTC mRNA ACTTGGCCTTCGTGG
14286309 2147 3643 2198 7517 DBN1 NM 004395 ILMN_1663975
Homo sapiens PRP3 pre-
TTCATGCTCACACAGGCT
HPRP3P, HPRP3, Prp3p, mRNA processing factor 3 GCATGGGGCTGAACACTACTGGGACCTTGCGCT ATGGGGATGGTGGGCTC RP18, PRP3 homolog (S cerevisiae) GAGTGAATCTGTGTTAG CAGGTCAGCTCTGCA
567 3143 18704893 19580977 PRPF3 NM 004698 (PRPF3), mRNA ILMNJ 715705 Homo sapiens F-box and WD
ATGGCCCAGACTGACTC
FBX29, FBXO29, FBW6, repeat domain containing 8 GGGGAGCTGGATGGTGAAACACCTGAAGATCTC CATCCCCTGACTTTCCCT MGC33534, FBW8 (FBXW8), transcript variant 2, ATATCGCCTCTCAAAAC TTGACTTCACCCTGT
17845178 331 76013 34076013 FBXW8 NM 012174 mRNA ILMNJ 703701
pOS + no GFs
Synonyms Probe_Sequβnce Probe_Sβquence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens tripartite motif-
BERP, HAC1, RNF22, RNF97, ACAGGAGTCCCTCTAGTTGTCTCCCTACCACCCT containing 3 (TRIM3), FLJ16135 ATACACACTGACAGAG transcript variant 1 , mRNA
112 01012 427 2726 44843097 TRIM3 NM_006458
Homo sapiens
CAGCTTAGATGGGAGGCTGAACGTGATGACTGG
NOC1. CBF2, HSP-CBF CCAAT/enhancer binding CTACACAACAGAGATGc protein zeta (CEBPZ), mRNA
10093893 1681731 17054976 CEBPZ NM_005760
Homo sapiens kmesiπ family CCCTTAGGACTCTGGTAI I I I
KNSL1. EG5, HKSP, TRIP5 26706845 96798926 10240892 KIF11 NM_004523 member 11 (KIF11), mRNA ATATTTCTGGAAGTTG p62, SNDI, FLJ43869, IBSN, Homo sapiens nucleoponn
CAGCTTCCAGTGGTGGCCGTAGACTTGGCTCGG DKFZp547L134, FLJ20822, 62kDa (NUP62), transcript AACTTAGTGGCACCAGA
1857 3142 2786906 28492642 NUP62 MGC841 NM_016553 variant 2, mRNA Homo sapiens SFRS protein
GCAGTGGGCAGAATACTTCTCACAGCTCAAAGAT
FLJ36101, SFRSK2 kinase 2 (SRPK2), transcript
AACAGTGATCACATTC
7589065 90831 9334393 SRPK2 NM_182692 variant 1 , mRNA
CACAGTCCAGGCCAAAA
TRN-SR, TRN-SR2, TRNSR, Homo sapiens transportiπ 3 ACTGTGTCCCACAATCAGAAACCTCCGTTGTGGC AGACAGGGGCAAAGCCC MTR10A, IP012 (TNPO3), mRNA AGAGGGGCCTTCACCG
TCACAAGCCAGGAAGG
3543976 19683225 20734475 TNPO3 NM_012470 ILMN 1663179
Homo sapiens transforming, AACAGCCCCACACACAG
MGC133242, ERIC1, GGAGCAGAAGACTAAAGAGAACGAGGAGCTGAC acidic coiled-coil containing CAGGGGCCTGAGAAGTT MGC117382 CAGGATCTGCGACGACC protein 3 (TACC3), mRNA AGCGGGAAACGCCGTC
19256012 60004346 62476013 TACC3 NM_006342 ILMN 1783673
Homo sapiens chromosome
ACCCCTGGATAAAGGCACTTTCACTGCCTGTCAC
MGC23138, MISS, c14_5346 14 open reading frame 32 TGATCAGCAGATACTG 69323926 77730597 7787893 C14ORF32 NMJ44578 (C14orf32), mRNA
Homo sapiens high mobility CTTGTGTAACCACTTGTC
HMGI-C, HMGIC, LIPO, BABL, CCCAGGGGAAGACCCAAAGGCAGCAAAAACAAG group AT-hook 2 (HMGA2), GCCTTAGGGCCAGATTC STQTL9 AGTCCCTCTAAAGCAGC transcript variant 1 , mRNA CCCTCTCTAGTCCCC
13068526 24040594 26388928 HMGA2 NM_003483 ILMN 1765829
HSET, MKLP2, RAB6-KIFL,
Homo sapiens kinesin family GAACGTCTCCGAGTCCCTCAACTCTCTACGCTTT KNSL2, MGC1202, member C1 (KIFC1), mRNA GCCTCCAAGGTGAACC
3380893 13305059 14073809 KIFC1 MGC149736, MGC149737 NM_002263
Homo sapiens GTPase activating protein (SH3
AAGAAGACTCGAGCTGCCAGGGAAGGCGACCGA
HDH-VIII, G3BP, MGC111040 domain) binding protein 1 CGAGATAATCGCCTTCG (G3BP1), transcript variant 2,
2196518 38455176 38781012 G3BP1 NM_198395 mRNA
Homo sapiens chromosome
FLJ36756, FLJ13081, MCMBP, CAGCGTTAATCCTGTATGGCCAGGAAACTGAGTA 10 open reading frame 119 MCM-BP GACTCCTGTGTAACCC
3527672 8682265 89897705 C10ORF119 NM_024834 (C10orf119), mRNA Homo sapiens mitochondrial nbosomal protein L47 (MRPL47), nuclear gene CACCTGCTACCTTAGAGTGTGAAGGTGATGGTA
CGI-204, MGC45403, NCM1 encoding mitochondrial ACTGCCACAGCAAAGGC protein, transcript variant 2,
19301846 26700177 27074762 MRPL47 NM_177988 mRNA
Homo sapiens pituitary tumor- GGTCCCAGACCAGCCCT
GCTTCGAGAGTTTTGACCTGCCTGAAGAGCACC rcPTTGI transforming 3 (PTTG3) on CTTCTCCCTGAATGTGTT AGATTGCACATCTCCCC chromosome 8 GAGTTGGTGGCAGGA 11390726 34101394 35954475 PTTG3 NR 002734
,*» ^- - pOS ♦ no GFs
Synonyms Probe_Sequence Raw XS pOS * β GFs Raw Raw Common Description Probβ_Sβquβπcβ_l
Homo sapiens SEH1 -like (S. CCTACTCATCCAAGACCC
Seh1, SEH1A, SEC13L; SEH1B ATGCTGACACTGCCAACCTCCAGTATCCTCACCC^ cerβvisiaβ) (SEHU), transcript AGCTTCATTGTCTCCATC TCGCAGACGATATCTC ^ variant 1 , mRNA TCTGGGAAGCCTGC
SEHU NM 001013437 ILMN 1717195
Homo sapiens DEAD/H (Asp- Glu-Ala-Asp/His) box
CHL1; KRG2; MGC9335. polypeptide 11 (CHL1-like GGGCCGTTAGGCTCTCAACATGACTATAGAGAC CHLR1. MGC133249 hθhcase homolog, S CCCGTGTCATCACGGAG cerevisiae) (DDX11 ),
4957187 98.82262 100.61429 transcript variant 1 , mRNA
Homo sapiens c-Maf-ιnduciπg
GGCGACATTCAGGTCTGTGTCATCCGGCACCCG protein (CMIP). transcript CGGACCTTTCTCAGCAA variant C-rπip, mRNA
13494345 14086429 CMIP NM 198390
HTR3. TCPZ; Cctz;
Homo sapiens chaperonin MGC126214, MGC126215. containing TCP1, subuπit 6A ACAGGCAGAGGTAAAAAGATGATGGAAGGTGTG TCP-1-zeta, TCP20, MoDP-2; (zeta 1 ) (CCT6A), transcript GTGACTAAGGGCCACGG TTCP20; CCT zeta-1, CCT- variant 2. mRNA
2071 7227 2095281 CCT6A zota; CCT6 NM 001009186
Homo sapiens YY1 ATGCTCTTTTAGAACGGG
UCRBP; YIN YANG-1, DELTA; TGCCTGTTCAGTTACAGAAAGTGGTGCTCAGTTG transcription factor (YY1 ), AAACGGCTCAGATCCTG NF E1 TAGAATGTATTGTACC mRNA CTGTGGCACGGGGCC
1268.0809 4787 389 49669976 ILMN 1658800
Homo sapiens CLP 1.
GAGAAGAAGGTGAAATC cleavage and polyadenylation CCTAGAGGCAGATGGGCTGAGATAAAAGACTGT
HEAB; hClpi TTGTGCTGAGTGGGTGT factor I subunit, homolog (S. TGGGGCCACCTGACCAG CTCTCTCAAAGGCCAG cerevisiae) (CLP1 ), mRNA
251.95595 CLP1 ILMN 1794912
Homo sapiens proteasomβ
GAAGCCGGTGGGGCCTT (prosome, macropain) 26S GGGATTTTGGACCAGGGGGAGGGTGTCCTGATT
S9, p44 5, MGC3844 CGGAAAGAGAGAGCAGG subunit, non-ATPasβ, 11 ATTTTCGATGAACCCCC CTGAAGAGGAACGATA
587 91846 PSMD11 NM 002815 (PSMD11). mRNA. ILMN 1727332
Homo sapiens stomatin GGTCTTCCAGTATCGCA hUNC-24, FLJ36370; SLP-1; AGGGCCTGCTGCTTCCCTGGCGCTGCTCCCAAA (EPB72)-lιke 1 (STOML1), GTTCTTCGAATGAAAGCC STORP GATTTCTGACTCATCTG mRNA. AAGGAGCACACCGCC
19803928 209 11844 STOML1 NM 004809 ILMN 1724540
Homo sapiens chemokine (C-
TGAACATCCTGCTTTTCG X-C motif) ligand 6 TCCTGTGTGTCATGTTGGTTTTTGGTACTTGTAT
GCP2; GCP-2, CKA-3, SCYB6 ATTGGCCAGCGATGGGT (granulocyte chemotactic TGTCATTTGGAGAAAC GTCTGCGCGCCTTGG protein 2) (CXCL6), mRNA.
125.526566 28447678 313.79764 CXCL6 NM 002993 ILMN 1729963
Homo sapiens similar to
CCAGAAGCTTTATCATCGGTTATTAAGGAGCTTC
MGC150539. FLJ21869 RIKEN CDNA 2410129H14 GCAAGGCTACTGAAGC
142.B6429 299.2143 30497263 LOC440145 NM 001071775 (LOC440145). mRNA
Homo sapiens heat shock
HSP7(M; HSP70L1. GGACTCCTTTGCCAGCTCGAAGACAACACACATT 7OkDa protein 14 (HSPA14). MGC131990 GCAAGCCCCTGGAAGC transcript variant 1 , mRNA
468.56012 HSPA14
Homo sapiens chromosome 1
DKFZP547N043. PRO4323; open reading frame 124 GCCATCCCAGGATGTGAGTGGGTCTGAAGATAC DDDL1880, dJ876B103; RPS^ (C1orf124), traπscπpt variant ATTCCCAAATAAACGAC 876B103
55.95943 96.48512 97 847626 C1ORF124 i. mRNA
pOS + no GFs
Synonyms Probθ_Sequeπce Probe_Sequβncθ_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens small nucleolar RNA, C/D box 36A CACTGAATTCAACCTTGAAGTGCGAATCCATGAG RNU36A, U36a (SNORD36A) on chromosome C I M I IAACCCTGAGC
12020178 213 32262 221 06012 SNORD36A NR 002448 9
Homo sapiens adenosine A3 GCAGCGAGAGCTCACGG
AD026, RP11-552M11 7, A3AR, receptor (ADORA3), transcript AATTCCTCTCGTGCCAAA CCTTCAGATTCCCCATCAACAAACACTTGAGGGC bA552M11 5 CTGTATGCCTGGGCCA variant 2, mRNA AGGAAACCCAGTTGG
85935165 131 38512 13349344 ADORA3 NM 000677 ILMN 1795139
Homo sapiens GCCTTTATGGGTGATCC
PP1, lOPPP, MGC111556 PP GAGAGCCCCTTCAAGTGTGATCCTGATGCTGCC pyrophosphatase (inorganic) 1 AGGGAAGATTGG I I I I G SID6-8061 AGAGCCATTGTGGATGC (PPA1), mRNA CTGATCAGATTCCACC
5437 798 9738855 9947848 PPA1 NM 021129 ILMN 1745529
Homo sapiens superkiller CTGCTCAAATTCTGCGAT
MGC142069, Dob1, KIAA0052, GAAGGCAGCATAATTCGTTGTATGAGGCGCCTG viralicidic activity 2-lιke 2 (S TGCTGCACATAGAGGAG Mtr4 GAAGAATTGCTTCGACA cerevisiae) (SKIV2L2), mRNA CTCAGAGAGCTACAG
56763513 87059766 880 19763 SKIV2L2 NM 015360 ILMN 1696708
Homo sapiens
MCM2, CDC47, P1 1-MCM3, minichromosome maintenance
AGATTCTCAGCTTCCCCAGGAGCAAGACCTCTG P1CDC47, CDABP0042, complex component 7 AGCCCGCCAAGCGCGGC P85MCM, PNAS-146 (MCM7), transcript variant 1 ,
6304388 251 50595 267 49344 MCM7 NM 005916 mRNA
Homo sapiens nbosomal RNA
GTCCTATAAATGCACCTCCTGTCAAAACCATGCC
RRP1. KIAA0179, Nπp1 processing 1 homolog B (S TGAGAGGTCCCGGCTG cerevisiae) (RRP1B), mRNA
10036924 17962262 182 95595 RRP1B NM 015056
Homo sapiens enhancer of
AGCACCCCTCAGTTCCT zeste homolog 2 (Drosophila) AGTGTGACCCTGACCTCTGTCTTACTTGTGGAGC
EZH1, ENX-1, MGC9169, KMT6 GTGCCTCAGCCCACAGG (EZH2), transcript variant 2, CGCTGACCATTGGGAC CCACTGTGATAATGGT
48680367 10903142 1207 7059 EZH2 NM 152998 mRNA ILMN 1720998
Homo sapiens thioredoxin CTTTCCCTGGAGAATGG
DKFZp781O2021, TMX2, CGI- CCCCCAAGGACTCTTGCTTCCTCAAGCCCTTCTG domain containing 14 GATGTGAAGCAGTAGAC 31, MGC111151, PIG26 GCTTCGTTTATGGTCT (TXNDC14), mRNA CGCAGCCACGCCGATG
1132 3392 18160726 1832 031 TXNDC14 NM 015959 ILMN 1697440
GCTCAAGGAAAGATAAA
Homo sapiens KIAA0182 CCGGTGCCTCGGTCACTCTGGGGGCAGTTTAGA
GSE1 GCTGGGCGGAAGGAGG (KIAA0182), mRNA TGCTGTGAAATTAAACC TGTGCGTGGCTTCTGGG
217 96011 4703018 481 2976 KIAA0182 NM_014615 ILMN 1700681 MGC20625, ATRIP, DKFZp762J2115, DRN3, Homo sapiens ATR interacting GCTGGCGTGCCCATGTT
GAAACCGATGTGGAAGACCCCGAGGTGGAGTGT FLJ12343, MGC21482, protein (ATRIP), transcript GCAGATATTTTCCCGAGT GGCTGAGGCCCTGAGTG DKFZp434J0310, MGC26740, variant 2, mRNA TCCCCAGAATGGATG
7895362 25395595 259 16428 ATRIP AGS1 NM_032166 ILMNJ653292
Homo sapiens UPF2 regulator smg-3, KIAA1408, MGC138835, CCCCAGCAGAGTTGAGT of nonsense transcripts TGCTGCCCAATCTTCACCAGCTTCAGAAATCTGA HUPF2, DKFZP434D222, AGTTGTAGCAGACACCA homolog (yeast) (UPF2), CCTTTGCCGATGCTGC RENT2, MGC138834 CATGCCCTTGAGCCTA transcript variant 1 , mRNA
8940893 4321 798 44933975 UPF2 NM 080599 ILMN 1808765
CTGTGGAGGATGCAGGA
Homo sapiens valyl-tRNA AGCTCCAACAGACAGAAGCAGAGCTCAGGAAGG
G7A, VARS2 TTACCTTCTTATGAACAG synthetase (VARS), mRNA TGGATGAGGCCATCGCC GCAGTGGCGCTGACC
915 15594 1379 1809 13894309 VARS NM 006295 ILMN 1661809
pOS + no GFs
Synonyms Probe Sequence Probe_Sequence_l Raw XS pOS + β GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens ADP-
CCTGAATACCATTTGTGT
FLJ23293, ARL3IP2, atlastιn2, πbosylation factor-like 6 GCAGGCCTGACTGACCAGGTGTCTCATCATGCC CTGAAGGGCTGAAGATG ATL2 interacting protein 2 AGATTAAAGACAGACTG
TGGACAGGCTCTAGC
9341439 6202768 656 36426 ARL6IP2 NM_022374 (ARL6IP2), mRNA ILMN 1657603 Homo sapiens nucleoporin ACCCACCATTATTCTCAGTGCCTACCAGCGAAAG
MGC8530
837 256 6743214 7131 7227 NUP88 NM 002532 88kDa (NUP88), mRNA TGCATTCAGTCCATCC
SIZ2, MIZ1, miz, ZMIZ4, PIASX- Homo sapiens protein inhibitor TCACCAGCCCTGAGATT
CAGCCATCTTCTGTAAGGGTGCCCAGTGTGACT ALPHA, MGC102682, PIASX- of activated STAT, 2 (PIAS2), GAGGCCCCATACACCAG TCGGTTGATCCTGCTGC BETA transcript variant beta, mRNA TGAAGAGGAGCAGGAG
22360178 2991 606 31600894 PIAS2 NM 004671 ILMN 1696151
CTCCTACAACGACTTCCT
Homo sapiens FOS-like CACTGCCACACTCTCCATCACCCTCTTCCTGTGA fra-1, FRA1 CCGGGCATTCCTCCAGT antigen 1 (F0SL1), mRNA TCCACCCAACCCTATC
472 5268 16062976 1639231 F0SL1 NM 005438 AGACACCCCTGCTGT
ILMN 1669465
Homo sapiens nucleoporin like ATTACTGTACAT AGAGAG
GTTACTACTGGACCCACTCCTTTCAGCACCATGC
PRO2463, KIAA0410 1 (NUPL1), transcript variant ACAGGTGGGCAI I I I I G
CAAACGCAGCAGCCGT 1 , mRNA GGCTACCTGGTTCGT
3476181 177 58095 18365594 NUPL1 NM 014089 ILMN 1735930
Homo sapiens mitogen- CATTGGCGTCAAGTACT
MKK7, Jπkk2, PRKMK7, TTTTATGAGTGTGTGTCCGCCCACCCCCACCCC activated protein kinase CGGAGAAGCAGGAGCG MAPKK7 CTTCAGTGTTAAGTGGG kinase 7 (MAP2K7), mRNA GAATTTCGACGATGCCA
42 81552 933937 97 13196 MAP2K7 NMJ45185 ILMN 1708486
Homo sapiens sorting nexiπ 2 CAAGCTGCATGTCCTGACCCTCTTTGAATTAAGT
TRG-9, MGC5204
529 11426 3493 1309 39129893 SNX2 NM 003100 (SNX2), mRNA GGACTGTGGCATGACA
Homo sapiens DEAH (Asp-Glu
GCCATTCTTCATCATTGTTTAAATTTTGGCTGGAT
MLEL1. DDX36, KIAA1488 Ala-His) box polypeptide 36 GCCAAACCCTGGGAC (DHX36), mRNA
234 11844 377 87262 38831012 DHX36 NM 020865
CGCAATGAGTAGGGCTG
Homo sapiens zinc finger TTCCAGCCTGCCAGTCATGAATCTCAGACAGCCT
FLJ20070 GGTCTCGGCCATGGAAA protein 586 (ZNF586), mRNA GCCACCTATTGCCCTG GCATACCTCAGTGCTC
191 00595 23923929 24287677 ZNF586 NM 017652 ILMN 1669377
Homo sapiens zinc finger ATTGCAGGGGATTGGTTCCAGCACCCTCTAAATC
HSZFP36 protein 823 (ZNF823), mRNA CACAGATGCCAAGTCC
3906421 7981967 82 77318 ZNF823 NM 001080493
Homo sapiens nucleoporin
CTCTGCCTGGATGCTGTTTGTGGTTACCTTGTTG
N155, KIAA0791 155kDa (NUP155), transcript AGCTCCAGTCTATGAG
3499268 82926013 87584766 NUP155 NM 153485 variant 1 , mRNA
Homo sapiens coiled-coil GTCCGCCCTGCTGCGTC
ATCTGCTGCCTATTAGGTTCTTCTGTGACATGTG
FLJ10294, HSPC128 domain containing 59 TGTTCGTCAGCTGAGTTC CCTCCCAGCAGTGAAC (CCDC59), mRNA CTTGTGAATCTCTGT
1311 756 16480642 16806976 CCDC59 NM 014167 ILMN 1695792
Homo sapiens family with
KIAA1895, FLJ22794, sequence similarity 111 , GTGCCGGTAGTACAGATAACCCCTCATAAAGATG DKFZp686A06175 member A (FAMI 11A), CTTATCTAACCTCccc
577 30597 1287 0559 1349 5269 FAM111A NM 022074 transcript variant 1 , mRNA
Homo sapiens chromosome 5 GCCTGGAGGTCTTCAAG
ORF1-FL49 open reading frame 32 GAGTCCCTAATGCTACA GCCACCTCTGACAGGTGTGCCTGCCCCCATCTC TTCTGATTGCTGTTAAC
(C5orf32), mRNA GTGCGGCCACTCCTAC
187 45595 375 13928 3902226 C5ORF32 NM 032412 ILMN 1667416
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens SERTA domain GGAATGTACTTCAGGGT
Seι-2, TRIP-Br2, MGC126688, GGAGGTATAACCTTTCCCCCACAGACCTGAGAG containing 2 (SERTAD2), CTAAAGAGATGGCTTCT MGC126690 CTGTGCCTTTTCTATGC mRNA GGAGATAGCTCAACCG
987 28094 3387 906 3652931 SERTAD2 NM_014755 ILMN 1665873
FLJ12556, NDC1. NET3,
Homo sapiens transmembrane CCTCATGCTTCCAGTAAACCACCCCGGATTTCAG FLJ34120, FU10407, RP4- protein 48 (TMEM48), mRNA GAAGCCTTGTGGACAC
51 295555 453 38095 5162476 654H19 1 NM_018087
Homo sapiens homeobox C6 GGGTTTGGCTGTCAGTG
TCCCTTCGTGTTACCCTCCTGTATAAATCCAACC
CP25, HOX3C, HHO C8, HOX3 (HOXC6), transcript variant 1, GACATGGGGAGCTGGAT TCTGGGTCCGTTCTCG mRNA GGAAATGCCTCTCACT
16709297 786 7643 10269143 HOXC6 NM 004503 ILMN 1716907
Homo sapiens ribonucleotide CCCGGGAGGGCAGAGC
GTGTCCTGGGATTCTCTGCCCCCTCTGAGTAGA
RR2M, R2 reductase M2 polypeptide CAGAAGAAGGCTCATTA GTGTTGTGGGATAAAGG (RRM2), mRNA GACCTGGGGGACCCAAA
104 825165 80060596 9303476 RRM2 NM 001034 ILMN 1711491
Homo sapiens ubiquitin-
ATTATACGCTGGCAACAC conjugatmg enzyme E2M CGGCAGCGGTAGGATGATCAAGCTGTTCTCGCT AGAGGCAGCCCGCACAC pseudogene 1 (UBE2MP1) on GAAGCAGCAGAAGAAGG CTGCGAGTGGCAAAC
20801231 10809762 12240595 UBE2MP1 NR 002837 chromosome 16 ILMN 1741673
Homo sapiens seπne/arginine AGAGTCGAGCAAAAGCC
POP101, SRM160, MGC39488, CAACTTTCAGAGCCTCTTGTATTTGGAAGGCTGG repetitive matrix 1 (SRRM1 ), TTCTCCACCTGCTCCCC 160-KD AAGGGCCCAGACTTTG mRNA CCAGCTCATTGTCATC
12598976 18506892 1894 731 SRRM1 NM 005839 ILMN 1705745
CTGCCTAGTGTATTCAAC
Homo sapiens ubiquitin B CCCTGCACCTGGTCCTGCGCCTGAGGGGTGGC
FLJ25987, MGC8385 AGAAGGACTGTGGTCAT (UBB), mRNA TGTTAATTCTTCAGTCAT
GTAACAGGTAACCAC
17962023 4368243 46068223 UBB NM 018955 ILMN 1668778
Homo sapiens islet cell
AGACCTGACTGCCTGGTTCAGCCTCTTCGCTGA
ICAp69, ICA69 autoantigen 1, 69kDa (ICA1),
CCTCGACCCACTCTCAA transcript variant 2, mRNA
7 6144457 21580594 25522678 ICA1 NM 004968
Homo sapiens tumor
D8S1992, N33, OST3A, suppressor candidate 3 AAGAACCCACACAATGGACAAGTGAGCTACATTC MGC 13453 (TUSC3), transcript variant 1 , ATGGGAGCAGCCAGGC
8982476 20286809 2172 3142 TUSC3 NM 006765 mRNA
IPOB, NTF97, MGC2157, Homo sapiens karyopheπn GGCTCGAAAGGCAAGAG
TCAGAATTGGCAGCACAAAGAAAACGCCCTCTCC Impnb, MGC2155, IMB1, (importin) beta 1 (KPNB1), CCCAGCATCGGTTTTCA TGACTTGTATTGTGGC MGC2156 mRNA GAACACCTACATCTGG
7551 456 11201 215 11606256 KPNB1 NM 002265 ILMN 1805998
Homo sapiens integrator GAGGCACTCCCGGAGCA
CACAGGTGGAAACCAGCATCGAGGGCACCATTC
MGC16733, INT4, MST093 complex subunit 4 (INTS4), AAGTCTATGAAGGATCTT CCTTCAGCAAGCCTGTA mRNA CTGCAAGAGGCTGCC
24823096 5526726 581 0393 INTS4 NM 033547 ILMN 1789361
Homo sapiens diaphanous
FLJ34705, DRF3, homolog 3 (Drosophila) GTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAG
DKFZP434C0931, dιap3, (DIAPH3), transcript variant 1 , GACACCGATGCCAAAAG
DKFZp686A13178
149 97678 41844763 449 33096 DIAPH3 NM 001042517 mRNA
Homo sapiens nucleolar and
GGAGTATGTCACCTTCCT
LNP, FLJ13421, SAPL, BM037, spindle associated protein 1 CTAGGCTTTGCTTAGTATCATGTCCATGTTTCCT GGGGGCCTTGGCTTTGA PRO0310p1, Q0310, ANKT (NUSAP1 ), transcript variant TCACCTCAGTGGAGCT
TCTACAATGAAGCcc
1386 7893 1501 8893 NUSAP1 NM 018454 2, mRNA ILMN 1713636
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS * 6 GFs Raw Raw Common Genbank Description rl -— Probβjd
Homo sapiens fibroblast CCCTCCACGTTGGTTTG
GCTGTGTCTCAGGGGATTGTAGGAATACGAGGA
HBGF-5, Smag-82 growth factor 5 (FGF5) GCTATGATAGGGAAGGA
GTTTTCAGCAACAAATT transcript variant 1 , mRNA AACCCTGTTACAGAGC
131 57295 47289764 522 35596 FGF5 NM 004464 ILMN 1791253
Homo sapiens THAP domain
GCCTTACTCTGGAAGCGGCGAGCCGAGGCAGC
MGC10963 containing 7 (THAP7), CCTTGATGCCCTTGACAA transcript variant 1 , mRNA
13853513 14209763 THAP7 NM 030573
Homo sapiens phosphoπbosylglyciπamide formyltransferase,
PRGS, PAIS, GARS, AIRS, phosphon bosylglycinamide CAGTCACAGCCATCCGGGAAAATCTCATATCAGC PGFT, GARTF, MGC47764 synthetase, CCTTGAGGAAGCCAAG phosphoπbosylaminoimidazol e synthetase (GART),
256 12262 44643927 4646518 GART NM 175085 transcript variant 2, mRNA
FP852, FLJ32402, MGC4614, Homo sapiens chromosome 6 ATTTGCCCGCATCCTCCT open reading frame 106 AGCCCCAAGAGATTGCAGATGTCAGCGTCCAGA (JJ391O224, RP3-391O22 4, ACTGACCTAGTGGCATT (C6orf106), transcript variant TGTGCAGCCCCAGCAGA FLJ22195 CAACCTCCAGGATCC
1664628 16363095 18949345 C6ORF1O6 NM 024294 1, mRNA ILMN 1684623
Homo sapiens suppressor of
CCAGCCCCGATGCAGGAGAGCTGTCCCTTGCTT
SUV3 var1 , 3-lιke 1 (S cerevisiae) CCAGATTGGTGCAGCAA (SUPV3L1), mRNA
120 10595 144 36844 14672263 SUPV3L1 NM 003171
Homo sapiens sulfiredoxin 1 GGCCAAAGGAGCAGCTG
Npn3, SRX1, C2Oorf139, GGCAGGCCTTGTTCTCACTGCCCTCTAAGGGAA homolog (S cerevisiae) TGGAAGTGAACCTAAACA YKL086W, dJ850E92 CTTGGTCACTCGGCACT (SRXN1), mRNA CAATGACAAGTGTGG
409 16846 10146809 1091 781 SRXN1 NM 080725 ILMN 1721926
Homo sapiens chromosome
CGI-99, LCRP369, CLE7, CTGCTCAAATTCTGCGATTGCTGCACATAGAGGA 14 open reading frame 166 CGI99, CLE GCTCAGAGAGCTACAG
24067893 29866392 3030056 C14ORF166 NM 016039 (C14orf166), mRNA
Homo sapiens chromosome TCCCAGATTTACCTCCTG
GACACTCTCAGAACCCACACCAGACCCACCAAAT
CLLD6 13 open reading frame 1 GGGGAGGGCTGGACTG CAGTTTGAGAACTGCC (C13orf1), mRNA CAAGGCCACTGTCATT
12340178 19028928 19589761 C13ORF1 NM 020456 ILMN 1803357
Homo sapiens heterogeneous nuclear πbonucleoprotein A/B CCAGAGCTCTAGGTGTTTAGGCAGCGTGTGGTG
ABBP1. FLJ40338 (HNRNPAB), transcript variant TCTGAGAGGCCATAGCG
2, mRNA
6977 6973 11413522 1183323 HNRNPAB NMJ304499
Homo sap.ens ""Mnhfte CTGACTCCTGCAGGCAC
NDPKA, NM23-H1, NDPK-A. cells 1 , protein , (NM23A) TGGGGAGCTCTGCTGGA GGGCCAAGAGATGGTGCTACTGTCTACTTTAGG NM23, AWD, GAAD expressed ,n (NMEIJ ATTGGGGGTTTAAAAC GATCGTCTTTCAAGGCG transcript variant 1 , mRNA
97751785 25451428 271 75177 NME1 NM 198175 ILMN 1652865
Homo sapiens hypothetical
GCACTGAAGGACTTGGCTGGTGGATGGGGCACT
MGC104723, gs103 protein LOC283951 TGGCTATGCTGATTCGC
34091428 453 3643 462 51843 LOC283951 NM 001010878 (LOC283951), mRNA
Homo sapiens meiotic nuclear AGGCTTTAGCCCTGGAC
CAAAAGCAGGATGATAACCATATCCCCCCAGTGC
GAJ divisions 1 homolog (S CCAGCAGGTGAGGCTCG TCATCAAAGTAGGACA cerevisiae) (MND1 ), mRNA GCTTGGATTATTCTGC
594769 284 19763 32004346 MND1 NM 032117 ILMN 1709623
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequeπce_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe Id
Homo sapiens ligase I, DNA, CAACCACTACTACCCATT
CTTCCCTCGGTTTATTCGAGTCCGTGAAGACAAG
MGC130025, MGC117397 ATP-dependeπt (LIGI), CAGAAGAGCAGAAAGCA CAGCCGGAGCAGGCCA mRNA TCTGCTGTGTGAGCG
93 736435 257 13928 283 1726 LIG1 NM 000234 ILMN 1673535
Homo sapiens TCCCCACTCTAAGCACTG
GGCGTGAGCCACTGCGCCCGGCCAGAATGGCA
KF, DKFZp686F03259 arylformarnidase (AFMID), CCTCCCCTACTCCCCGC TTATATTTAAATAGTTCA mRNA ATCTTTGGGGAATCG
9651041 55656067 68971115 AFMID NM 001010982 ILMN 1739605
Homo sapiens nucleoponn CCGTGGGCTTCCGGCTC
AGTTGCAAGAGGACCGCATGTACCCGGACCTTT
N155, KIAA0791 155kDa (NUP155), transcript TCTGTGGATGGCAGGTC CCGAGCTGCTTATGGTG variant 1, mRNA ATGTGAAGACATCAAT
74541283 5058486 5721771 NUP155 NM 153485 ILMN 1722713
Homo sapiens RNA GATCGGCCCTGAACCCA
TCGCCAAGCACCAGCTATAGGTCACAGCCACAT
FU10581, HC90 methyltransferase like 1 CAAAGGACTCCTCGCTC
CACTCACAGCTGATCAC (RNMTL1), mRNA CTTCAAGCCTCCACCA
24596844 482 19763 511 6018 RNMTL1 NM 018146 ILMN 1729402
Homo sapiens solute carrier family 29 (nucleoside transporters), member 1
ACTGATCCCTGCTTGTGCAGGCCAGTGGAGGCT
MGC3778, MGC1465, ENT1 (SLC29A1), nuclear gene
CTTGGGCTTGGAGAACA encoding mitochondrial protein, transcript variant 4,
8807495 289 88095 329 1476 SLC29A1 NM 001078174 mRNA
Homo sapiens ribosomal pp90RSK2, MAPKAPK1B. CLS, ACCCACCAGGAGACCAG protein S6 Kinase, 90KDa, GATTCACCTGGCATTCCACCTAGTGCTAATGCAC RSK2, RSK, S6K-alpha3, p90- GTGTCTGAAGTGGACTG polypeptide 3 (RPS6KA3), ATCAGCTTTTTCGGGG RSK2, ISPK-1, MRX19, HU-3 TGTGAGCCTGGGCATT
52675934 134 08928 152 05179 RPS6KA3 NM 004586 mRNA ILMN 1741491
Homo sapiens XPA binding GCGGTGTCAGCCTTTTC
GCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCT
MBDIN, ATPBD1A, NTPBP protein 1 , GTPase (XAB1 ), TTCAGAGCATTTGTTTGA GCACTGTAAGTTGCCC mRNA CTGACTTCCAAAGCA
60473926 1096881 11642726 XAB1 NM 007266 ILMN 1682910
Homo sapiens Eng nm GCAGCCCCAACCCTACC breakpoint region 1 (EWSR1 ), TCATCTGTGCTGAAAGAC GGGAACCCCTTGTGAGCATGCTCAGTATCATTGT
EWS transcript variant EWS, GGAGAACCAAGAGGGC
GCTGAAACTGCCTGG
1898981 9793772 11573923 EWSR1 NM 005243 mRNA ILMN 1762498
Homo sapiens tRNA splicing
MGC4440, MGC2776, SEN2, GCACTTTCATACGCAGGCATCTCTTGTTACCTAC endonuclease 2 homolog (S SEN2L ATCTAAGCTGTTCCCG cβrevisiaβ) (TSEN2), mRNA
142 1726 2566726 26596844 TSEN2 NM 025265
AGAACACAACAAGCCCC
Homo sapiens atlastin 3 AGAACACAACAAGCCCCTACTGATTTCTGGGTTT
ATL3, DKFZp564J0863 TACTGATTTCTGGGTTTC (ATL3), mRNA CTGCCACGGCCACAGG TGCCACGGCCACAGG
837 1476 1399685 14706226 ATL3 NM 015459 ILMN 1751086
Homo sapiens ARP1 actin- related protein 1 homolog A, GCACAGCCTCGCACAAACCACATTGCCTGGTGG
ARP1 centractin alpha (yeast) GGCCCAGTGTACTGAAA
14488477 3326581 3601 4395 ACTR1A NM 005736 (ACTR1A), mRNA
Homo sapiens BTB (POZ) GATCCATCACAAAGCGA
GGTGGCTGCGCGAGGGACCGAGTACTAGAGCT
BTBD14, MGC23427 domain containing 14A AGTCATGGGAGAGCCAC GCTTGCATGCGTTACTAA (BTBD14A), mRNA ACTTGATGGTGGAATA
14690178 199 99762 20626845 BTBD14A NM 144653 ILMN 1693287
pOS + no GFs
Probe.Sβquence probe |d Probe_Sequencβ_l Raw XS pOS ♦ 6 GFs Raw Raw Common Synonyms
Genbank Description
Homo sapiens poly(rC)
MGC110998. HNRPE2, hnRNP- CCACCCATGATCCATCTGTGTAGTTTCTGAACAG binding protein 2 (PCBP2), E2 TCAGCGATTCCAGGTT
9985873 27013773 29913398 PCBP2 NM 005016 transcript variant 1 , mRNA Homo sapiens family with
ATAAAATTGTTTATCCTC
KIAA1895, FLJ22794, sequence similarity 111, CAAGCACCCTCCCTCTAGGTCCAGGGACTATCA CACAACTGCCTGGAGAA DKFZp686A06175 member A (FAMI 11A), CAGAAGAAGCAGGCATG CCTCGGAGACCAGCA
2086726 4371143 46936847 FAM111A NM 022074 transcript variant 1 , mRNA ILMN 1663220 Homo sapiens cell division
ACCCTGCAGAGCTATGG
DKFZp686L20222, CDK1, cycle 2, G1 to S and G2 to M GACAAAGGAACAATTAAACTGGCTGATTTTGGCC TGAGGTGTGGATAAGGC MGC111195, CDC28A (CDC2), transcript variant 1, TTGCCAGAGCTTTTGG TTAGGTGCCAGGCTGT
9481317 42145593 49566846 CDC2 NM 001786 mRNA ILMN 1681591
Homo sapiens solute earner
GAAGCCCAGGAGGACTAAAGCTGAAAACATCCC
ZNT1. ZRC1 family 30 (zinc transporter), TGCTGTTGTGATAGAGA member 1 (SLC30A1), mRNA
13247261 22732678 23789345 SLC30A1 NM 021194
Homo sapiens processing of
CACAGGGAGCCAGTGAG precursor 7, πboπuclease CCAATACCTCCACCGTGGAGCTTGTTGATGAGC
0610037N12Rlk, RPP20, RPP2 GTCCCAGTAGTCTAAAAC P/MRP subunit (S cerevisiae) TGGAGCCAGAGACCGAC AGTTCATGTGTTCAC (POP7), mRNA
25215596 50288513 53398926 P0P7 NM 005837 ILMN 17654B0
Homo sapiens thyroid CCTTCACCCATAGTAATC
CGTCAGGTTGTCTTCTGGGCTGTGTGGACCTAA
HST17391 hormone receptor interactor 4 CTCCTGGGGCAGAAACA
TTGACTGCTTGTCCCAG (TRIP4), mRNA TAACACCCCAAAGGC
39816013 719631 7694976 TRIP4 NM 016213 ILMN 1790645
Homo sapiens protein kinase (cAMP-dependent, catalytic) CTCCTTGCAATCATGTGGACACCAATCACAAAAG
PRKACN1 inhibitor alpha (PKIA), TAAAGCCCTGGTGTTG transcript variant 6, mRNA
40647335 28557263 33038095 PKIA NM 006823
. „ ,. GCCAGCGGTGATTGCTA
GAACCCGCGTGCAACCTGTCCCGACTCTAGCCG
MT2 t^ZSF*™" CTTGAGGTAGTTTTTTAC CCTCTTCAGCACGCCAT
AACTACCATTTCCCC
16421506 36480812 39688508 MT2A NM 005953 ILMN 1797372
Homo sapiens armadillo
GTGAGTGGTCTCTGTCG repeat containing, X-linked 6 CCAGGCAGGGGCTCCCACAGAGCTTTGAGTAAC
FLJ20811 GGAAAGATGTAGGGATT (ARMCX6), transcript variant TTCTTGGTTGTGCAGTC GGTTCTCCAGGATCTT
53212256 593756 6000143 ARMCX6 NM 019007 1, mRNA ILMN 1800654
Homo sapiens KIAA0101 GCTGCCAGGGCAACCTG
L5, p15(PAF), OEATC1, AGGAGGGAACCCCGTTTGCGTGCGCCCAACTCC
(KIAA0101), transcript variant AGATAACAAACGCCCTCA OEATC-1. NS5ATP9 CAAGTGGCAAAAAGGAA 1, mRNA TCGCAAGTTAGGAGC
9580976 8540373 10471031 KIAA0101 NM 014736 ILMN 1742179
Homo sapiens smoothehn
AAGACCTCAGCCTCCCAGGCGCGCAAGGCCATG
FLJ38597, FLJ35365 (SMTN), transcript variant 2, ATTGAGAAGCTGGAGAA
37473682 12133095 13551012 SMTN NM 134269 mRNA
Homo sapiens DnaJ (Hsp40)
RDJ2, DNAJ, DJA2, DNJ3, AAAAAATGGGCTTTGCACACAATGGGTTTGGAGC homolog, subfamily A, member HIRIP4, PRO3015, CPR3 TGACTGGGAACAATGG 2 (DNAJA2), mRNA
21504392 8893723 10224697 DNAJA2 NM 005880 bA74P14 1, ZMYND1, Homo sapiens SET and ATCTGCTGTGCGGCCGT
GAAGAATGCGACGCCAACATCAGAGCATCCTAA ZNFN3A1, FU21080, MYND domain containing 3 GAACTGCTCCAACCGGC GGGAACGCAGTCAGAGG MGC104324 (SMYD3), mRNA AGGGAAAGGGCGAGAA
6448059 80211426 81523096 SMYD3 NM 022743 ILMN 1677530
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens eukaryotic
AAG1, NAT1, p97, FLJ41344, translation initiation factor 4 ATGGGCTTTATGTGCTAGATTTT DAP5 gamma, 2 (EIF4G2), transcript GCCTGGGCAAGTGCAC
10242464 17927297 18862014 EIF4G2 NM 001418 variant 1 , mRNA
Homo sapiens chromosome 9 GTGTGTGCCCTCTGCCA
AGCGTCCCTGGGCTCTATCCGCGAGGTGCCAGT open reading frame 140 GTCTTCGCTCTGTCCCC AGCGTGTGCAGGTACAT
(C9orf140), mRNA GTTCAATCAACCCCAT
14331934 522 09766 61673096 C9ORF140 NM 178448 ILMN 1745623
Homo sapiens vacuolar
MGC39512, hVps53L, HCCS1, CTGCACATCAAGCAGAACGTCCCCATCATCCGT protein sorting 53 homolog (S PP13624 FLJ 10979 GACAACCTGGCTTCCAC cerevisiae) (VPS53), mRNA
15717052 5207101 726 1226 VPS53 NM 018289
Homo sapiens diaphanous
FLJ34705, DRF3 homolog 3 (Drosophila) GATGAGACAGGAGTGATGGATAATCTGCTGGAG
DKFZP434C0931, dιap3
(DIAPH3), transcript variant 2, GCCTTGCAGTCCGGGGC
DKFZp686A13178
15082678 59335596 6697976 DIAPH3 NM 030932 mRNA
Homo sapiens coiled-coil
GACTCTGATGTTGGGTAGCTGGCCTCTGTGGGG domain containing 44 ATTGTAAGTGCCCTGAG
6380476 7433726 7552893 CCDC44 NM 016360 (CCDC44), mRNA
Homo sapiens peroxirβdoxin 4 CTGCCCTGCTGGCTGGAAACCTGGTAGTGAAAC
PRX-4, AOE37-2 (PRDX4), mRNA AATAATCCCAGATCCAG
4291 506 14515355 16241 322 PRDX4 NM 006406
Homo sapiens hypothetical CTGTATTTAAGGGTAAGC
CCTGGGTCTCAGCCCCGCGTACGGCCTTTCACG protein MGC39900 CCCACAGCGGGCAGCAC AGTCTTCAAGCCTTCAG (MGC39900), mRNA AAACAGCCTGGGAGC
14287262 23003094 24028928 MGC39900 NM_194324 ILMN 1748366
Homo sapiens tuftehn
GCCCCAGGATTAAGATG interacting protein 11 GGCATTGGCGTGGCCGCTAGCTCTGTGCCCATG
FLJ22086, TIP39, bK445C96 GATGCCTTAAGCGATGG (TFIP11), transcript variant 2, AACTTTAAGGACCTCAT CCCAGGGGTGCTTGGT
23053094 32081845 331 38095 TFIP11 NM 012143 mRNA ILMN 1746682
Homo sapiens isocitrate dehydrogenase 3 (NAD+) TTCTTCCCCTTCATTTAC
GAGCTTGGGCTTAGGCTTGGGCTCAGCTTTTGA alpha (IDH3A), nuclear gene AAACTGTCTGTTAACAGA CCCTCAGGCATCTCCTT encoding mitochondrial TTGGCAACCAAGAC
13532262 261 88095 278 5518 NM 005530 protein, mRNA ILMN 1677061 Homo sapiens proteasome (prosome, macropain) 26S ATGCTGTTCTTCACAGAT
GGATGGCACAGCTTCTGGATCTATCTGTTGATGA
MGC75406, p55 subunit, non-ATPase, 12 TTCATGGGCCAGATTGT GTCCGAAGCCTTTCTC (PSMD12), mRNA GTACCGCGGGGATCC
665 8976 1327 6685 1401 8226 PSMD12 NM 002816 XM_946055 XM_946058 ILMN 1654165
Homo sapiens myotubularin GACACACCTAAACATGTG
KIAA0371, FLJ32333, FYVE- CCTAGTGACAGGTGCCAAGAGGTTATGATACGG related protein 3 (MTMR3), GAATCCCAATGCCGGTG DSP1. ZFYVE10 GTTTCTTGGGTCTGATG transcript variant 3, mRNA GGCCCCCTCATCCTG
42694763 1782 8643 2022 106 MTMR3 NM 021090 ILMN 1795944
Homo sapiens histone cluster GGCGTGTGACCATCGCGCAGGGTGGCGTTTTGC
H2A/m, H2AFM 1, H2ab (HIST1H2AB), mRNA CTAATATTCAGGCGGTG
68824196 342 9726 4689226 HIST1H2AB NM 003513
Homo sapiens cofactor required for Sp1 CAGGGTTTGAACCGGAA
GGCAGTAATTTCGCTGTATAACAAGCATAGACAA
CRSP33, MGC12284, MED7 transcriptional activation, GCGGGAGTAGGTAGCTG ATGAGTGTCCCTGCAC subunit 9, 33kDa (CRSP9), CGTGGCTAACGGAGAA
4441431 7609089 81 747665 CRSP9 NM 004270 mRNA. ILMN 1713630
pOS + no GFs
Synonyms Probe_Sequencβ Probe_Sequβnce_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens sialic acid
SigleoXII, FLJ38600, Sιglec-12, CCCACTTGCCTGGGATG binding Ig-like lectin 12 ATGCTGCTGCCCCTGCTATGGGCAAATGAAGAG S2V, SIGLECL1, SLG. Siglec- GCCCCACACTGTCACTC (SIGLEC12), transcript variant AGGGACAGTGGGGGCTG L1 AGCTGTTCTTTGATCA
7985589 36276428 51108093 SIGLEC12 NM_033329 2, mRNA ILMN 1659523
Homo sapiens lιn-52 homolog GGGGAGTCTCACCACGGCTAATTTGATGGAGAA
C14orf46, c14_5549 (C elegans) (LIN52), mRNA GGTTCGAGGCCTACAGA
8440608 16346844 16750595 LIN52 NM_001024674
RP11-19J33, FLJ33928, CENP- Homo sapiens centromere GTCCCACAGCGAGCCCTGGAGCTGGACAAGAAC
142168865 8809766 103430954 CENPP P NM_001012267 protein P (CENPP), mRNA AGAGCCATAGAAACTGC
CCCTGGCACAAGAAATT
Homo sapiens mutS homolog TCGGGAAGTTTGCCTGGCTAGTGAAAGGTCAAC
HSAP, HNPCC5, GTBP CCAGTCATGTGAAGCAA 6 (E coll) (MSH6), mRNA TGTAGATGCTGAAGCTG ACTGCCCTTTGTCCTC
85783093 15735393 16427227 MSH6 NM_000179 ILMN 1753554
Homo sapiens TBC1 domain ATGCACTTGGCAGTTAAT
GCCGTGTTTGCTTTCCGAGCAGTGAACCTGATG
FLJ11082 family, member 19 GGATCTGCTGTTGCTGG GAGGTGACATCACTGGC (TBC1D19), mRNA AGTGTGAGCGTGGAC
23508096 9500476 10732976 TBC1D19 NM_018317 ILMN_1801822
Homo sapiens zinc finger
GTAGCAGAAGAGGAGGA
UKp68, FLJ11806, MGC26892, CCCH-type containing 14 GATGGTGTCCCCAGCCCCCCAGGATACATGTCA GTGGCTACACAAACAAG NY-REN-37 (ZC3H14), transcript variant 1, GATCAAGAGGAGGACAT CTGAGGCACGAAGAGC
34590996 29659344 36356427 ZC3H14 NM_024824 mRNA ILMN 1812523
Homo sapiens regulator of chromosome condensation 1 AGCGCCGGAGTTCCTTGTGGCCGACGTGCACCA
RCC1-I, CHC1 (RCC1 ), transcript variant 3, AGGACAGGAAGATGTCA
16468401 8009903 9807051 RCC1 NM_001269 mRNA
Homo sapiens
MST098, PCMT, PCCMT, GTAGGAGAGAGGAGAAA isoprenylcysteine carboxyl CCTCGGCCTCTCTGTCATGCTGGGAAGTGCCTA PPMT, HSTE14, MSTP098, TGCTGGAAAGGTCGACA methyltransferase (ICMT), CTCTCTGGGCCACTGCT MGC39955 GTGTGGGGAGTTGGAG
674506 9949643 1055381 ICMT NM_012405 mRNA ILMN 1659543 sglGSF, Necl-2, IGSF4, MGC149785, DKFZp686F1789,
Homo sapiens cell adhesion TTGCCATGGGGACTGCC TSLC1, CTGCAGCTCTATTCCGAGCCCTTAGCACCCATTC molecule 1 (CADM1), ATCTGCTGTGTGGATAC synCAMI, RA175, SYNCAM, CGACCATAGTATAATC transcript variant 1 , mRNA CCATCGGAGGGGCCCA IGSF4A, STSLC-1. BL2, MGC51880, ST17, NECL2
10866822 26753928 33885596 CADM1 NM_014333 ILMN 1675375
Homo sapiens emopamil
TGCATGGAAACCATCACAGCTTGCCTGTGGGGA
CDPX2, CPXD, CHO2, CPX binding protein (sterol CCACTCAGCCTGTGGGT
23538928 40405597 44124762 EBP NM 006579 isomerase) (EBP), mRNA pp7704, MGC86949, RP1- Homo sapiens chromosome 1 ACATCAACGAGCTGACTA
ATGGCGCAGACAGATCCCGAAACCAATGATTGA 178F152, MGC131924, open reading frame 77 TGAAGCTGAGCGTGGAG AGCCTGCCCATCCTCCC DKFZP547E1010 (C1orf77), mRNA GACGTGCTGACCCGC
6196476 76184766 7874101 C1ORF77 NM 015607 ILMNJ 756542
Homo sapiens stem-loop
GCACTAGTTAGACTCTTTAGAATACTCCAAGAGT
HBP binding protein (SLBP), TAGGGCAGCAGAGTGG
5655393 9515893 10292059 SLBP NM 006527 mRNA.
Homo sapiens fragile X mental retardation, autosomal GACATCAGCGTGACAGCAGGAGACGCCCAGGA homolog 1 (FXR1 ), transcript GGAAGAGGCAGAAGTGTT variant 1 , mRNA
6192476 9233393 98458093 FXR1 NM 005087
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens major facilitator TGAGGAGCCCTATGCCCCTGAGCTGTAACCCCA
MGC11308 superfamily domain containing
CTCCAGGACAAGATAGc 5 (MFSD5), mRNA
350 78928 511 0476 541 6184 MFSD5 NM 032889
Homo sapiens chromosome GAGTGTTGCTGCTGAAG
AGGTGGCCTCACTGGCTCTTCTCAGGACAACTA
FU13909 16 open reading frame 59 CACATCCTTGCAATGTG AGCCTGCTGGTCAGGGC (C16orf59), mRNA GGAGTGCACAGGAGTC
42 5214 118030945 14851428 C16ORF59 NM 025108 ILMN 1713380
Homo sapiens opioid growth dJ331H24 1, FLJ21079, GGGCTGTTAACTGGCAGGAAAGATTTCAGCATC factor receptor-like 1 MGC102783 TGAATGAGTCCCAGCAC
81 918564 13820595 14672263 OGFRL1 NM 024576 (OGFRL1), mRNA Homo sapiens cell division
GGGCTTTTCCAAAAGCAA cycle 25 homolog B (S GCGCAGTGCCTTGCATACCCAAACCAGGTGGGA ACAAAGATAGGTTCCTCA pombe) (CDC25B), transcript GCGTTTTGTTGAGCATG GGTGACCAAAACTG
1456 5809 2403906 25938894 CDC25B variant 2, mRNA ILMN 1672947
Homo sapiens RAD51
AAAAATGTAAGCAAAATT
HST16930, BRCC5, HRAD51, homolog (RecA homolog, E GTGCCAAACCTACTAGGCCATTAGCCCTTCACCA ACAGTATGTAAAACACAC RECA. HsRad51. RAD51A CoIi) (S cerevisiae) (RAD51 ). TCTACCTGCTTGGTCT ATTGCTAATGGAGA transcript variant 2, mRNA
50 199356 54988075 59 103683 RAD51 NM 133487 ILMN 1651456
PREDICTED Homo sapiens
TGATGGCTTCATGATCCA hypothetical protein CAAGCTGGCCATGGGGGTCCCAAACAGTCATTC GCACAGTGCCTCACACA BC006130 (LOC93622), misc CAGGCTTAGATGATGAC AAGAACTATTGGGTG
20907262 261 62677 271 32263 L0C93622 XR 017952 RNA ILMN 1774800 Homo sapiens
ADOMETDC, AMD, adenosylmethionine ACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGT DKFZp313L1234, FU26964 decarboxylase 1 (AMD1), TGAAGCTTGCTAGGGA
387 69763 16046726 1975231 AMD1 NM 001634 transcript variant 1 , mRNA
Homo sapiens zinc finger and TTGCGTAATTCTTGCCGC
CCTTGGTCAGAGGGACTCAGGTTTGGGACAGCA
MGC23166 BTB domain containing 9 TCCCCCCAGCCCATCGT CAAGCTGAAGGCTGGAG (ZBTB9), mRNA TCCCTGGTTCTGTGA
15523096 3188601 354 5518 ZBTB9 NM_152735 ILMN 1657148
Homo sapiens acylglycerol CTGCCCTTCCCAGGTGATTCTGTAAGTTGTCCCT
MULK, FLJ10842
401 06427 497 35596 51464764 AGK NM 018238 kinase (AGK), mRNA CAACTGTACTTGGAGA Homo sapiens mitogen- p40, PRKM2, MAPK2, PRKM1, activated protein kinase 1 GTAGAACAGGCTCTGGCCCACCCATATCTGGAG p38, p41, ERK, ERT1, (MAPK1), transcript variant 2, CAGTATTACGACCCGAG P42MAPK, p41maPk, ERK2 NM 138g57
20603094 81978094 1007 14764 MAPK1 mRNA
Homo sapiens ubiquitin-like 5
CCACGTGTCTCTGGGGGACTATGAAATCCACGA
HUB1, MGC131795, FU46917 (UBL5), transcript variant 2,
TGGGATGAACCTGGAGC
31903892 3651 7144 UBL5 NM 001048241 mRNA
Homo sapiens partner of GCAGATGGGGGCAGAGA
GCTTAGCCTACCTTAAAAGGGCTCCGAACACTAC
KHRBP1 NOB1 homolog (S cerevisiae) TGTGAAACAGCTGCAGA ATTAGCCTACAGTTGG (PNO1), mRNA GCGGGACAAGGGTGCT
144 59763 25323094 274 1476 PN01 NM 020143 ILMN 1665356
Homo sapiens differentially
AGATACGAACACAACAGA expressed in FDCP 8 homolog CCAGGAGCTGAAGGACCCCAATGAGGATGAGCC
MGC104349, FLJ20186 AATTTCAGCAACTAGTGG (mouse) (DEF8), transcript AAACATCCGAGTGCTCC
ACTAGTTCCTGGAG
307 9143 4296101 450 3393 DEF8 NM 017702 variant 2, mRNA ILMN 1675092
pOS + no GFs
Synonyms Probe_Sequence Raw XS pOS + 6 GFs Raw Raw Common Genbank Descπption Probe Id Probe.SequenceJ
Homo sapiens protein kinase membrane associated
MYT1, DKFZp547K1610. GTTTGCTCCTGGACAGCAGCCTCTCCAGCAACT tyrosine/threonine 1 FLJ20093 GGGATGACGACAGCCTA (PKMYT1), transcript variant 2, mRNA
5497604 217 83095 27832678 PKMYT1 NM 182687
Homo sapiens protein kinase
GCTATGGCGGAGGATGG (cAMP-dependent, catalytic) ACTGTGTTTGATGGCCTCTGCTGTGTTTTAACAT
PRKACN1 GTTGCTTTTCAAATGTCT inhibitor alpha (PKIA) CGTGCTTCTTATATGG AGCTCAAATCAATTC transcript variant 7, mRNA
75 85225 442 2893 546 8684 PKIA NM 181839 ILMN 1711451
Homo sapiens prostaglandin E
GATGACTTGTCAGTGTTCCAGGTGTATCTTAGCT
TEBP, P23 synthase 3 (cytosolic)
AAAACTAGAGAATGCC (PTGES3), mRNA
2137 956 31987227 33794143 PTGES3 NM 006601
Homo sapiens S100 calcium
GGAGTATGTCACCTTCCTGGGGGCCTTGGCTTT
2A9, PRA, CABP, 5B10, CACY binding protein A6 (S100A6), GATCTACAATGAAGCCC
11368031 26813564 3025954 S100A6 NM 014624 mRNA
Homo sapiens isocitrate dehydrogenase 3 (NAD+)
ACTACACCTTATTTGGTC gamma (IDH3G), nuclear gene GATGCTGGACCACCTCAAGCTGCACTCCTATGC
H-IDHG GCAGCTACTGAGGGATG encoding mitochondrial CACCTCCATCCGTAAGG AACGAAAGCCCCCTC protein transcript variant 2,
91524756 29983809 36086558 IDH3G mRNA ILMN 1783695
Homo sapiens ATG4 autophagy related 4 homolog GCAGGCCATGCGGCCTCTGTCACATCTACTCAA
APG4A, AUTL2 A (S cerevisiae) (ATG4A), CTCTGCTGTTGACATGC transcript variant 2, mRNA
6699746 124 501785 13860596 ATG4A NM_178270
Homo sapiens enolase GCCCAGGCTTTTCCTGC
RTS beta, TYMSAS, RTS CCTACCGATCAAGATGAGTTCAGCTAGAAGTCAT superfamily member 1 TCTGGCTCACTGCTGCT alpha, HSRTSBETA, RTS ACCACCCTCAGGAATC (ENOSF1), mRNA CACAGATATGCAAAAC
12369762 149 90594 154 57262 EN0SF1 NMJ317512 ILMN 1731223
Homo sapiens chromosome 1
CCGAGCCGGAGTTACGGAGCACTTTCAGTGAGG
FLJ11588 open reading frame 165 AAGCAAATACGTCGTCC
15035133 4904393 6524001 C1ORF165 NMJJ24603 (C1orf165), mRNA
Homo sapiens annexin A1 CCTGGTGGCTCTTTGTGGAGGAAACTAAACATTC LPC1. ANX1
13507 34 17170 13 17881 822 ANXA1 NM_000700 (ANXA1), mRNA CCTTGATGGTCTCAAG
Homo sapiens protein phosphatase 2 (formerly 2A), ACCCACTTATTGCCTAAT
PR48, NY-REN-8, PPP2R3LY, CTACGTCATCTACTGCAAGTTCTGGGAGCTGGA regulatory subunit B", beta TAGTCATAGTTTGACAAT PPP2R3L CACGGACCACGACCTGC
(PPP2R3B), transcript variant TGCCCTTGTATTCC
5275612 97 87054 10303929 PPP2R3B NMJJ13239 1, mRNA ILMN 1661188
Homo sapiens zinc finger GAGCTGAAAGCTGCGGCGCCACTGGTGCCAGA
FLJ00086, DKFZp762F135 protein 598 (ZNF598), mRNA GTCAGATGTCACAGATGT
6920559 79032263 8100393 ZNF598 NM_178167
Homo sapiens transmembrane
GCCAACACCAACTCGTAGCTTTAGTGGCAGATG
KIAA0286, DKFZp686N1768 protein 194 (TMEM194),
GGAGTGGTCACAGACTC
9471979 22695596 264 33093 TMEM194 NM_015257 mRNA
Homo sapiens ribosomal
ACCCGGCGCTCCATTAAATAGCCGTAGACGGAA protein L41 (RPL41),
9667679 157 73096 17263928 RPL41 CTTCGCCTTTCTCTCGG NM 001035267 transcript variant 2 mRNA
pOS + no GFs
Synonyms Probe.Sequencβ Probe_Sequeπce_l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens ATPase, Ca+* ACATCTCCCTGACAACAC
SPCA1, PMR1, HHD, hSPCAI, transporting, typβ 2C, member AAAArτARAOrrAGRRG AGGCTGCAGACATTGGAGTTGCGATGGGCCAGA ATP2C1A, KIAA1347, BCPM 1 (ATP2CI). transcriptvarian, £££%%£££" CTGGTACAGATGTTTGC
508 1976 64507263 677 7976 ATP2C1 NM_001001486 4, mRNA ILMN 1667018
MGC11225, MGC10775, Homo sapiens MYC GGAGGCCCTTCCCAAGG MGC34679, MGC36767, orf1, associated factor X (MAX), TGTGGTGACTGTGCCTT CGAAAACGTAGGGACCACATCAAAGACAGCTTTC TTGCGGGACTC MGC18164 transcript variant 1 , mRNA ACTGTACATGCTCGGA ACAGT
16067679 34989343 39881845 MAX NM 002382 ILMN 1719661
Homo sapiens chemokine-like
UCK-1, CKLF1, CKLF4, CKLF2, CAGCCGAAAATAAAACATCGCCCCTTCTGCTTCA factor (CKLF), transcript CKLF3, C32, HSPC224 GTGTGAAAGGCCACGT
750 3893 1242 4434 13390017 CKLF NM 001040139 variant 6, mRNA
FLJ20147, FLJ33312, Homo sapiens NHL repeat CTCCCTAGGAGGCTTTT MGC45492, FLJ25621, containing 2 (NHLRC2), GCCCTCAGCTTGAATACA GCTAGCAACCCATTGCCACCACCTACTGTCTCCC DKFZp779F115 mRNA GTTCCTGGTGCATCA ATCCTGACTATCACTG
37936943 9599776 109 368454 NHLRC2 NM 198514 ILMN 1728742
Homo sapiens phenylalanyl- IRNA synthetase 2, dJ520B182, FARS1, HSPC320, ACATCCAAAGACGCACAAGACCAGCCACTGCTA mitochondrial (FARS2), PheRS CCGCATCACGTACCGCC nuclear gene encoding mitochondrial protein, mRNA
386 91428 5504143 57420593 FARS2 NM 006567
Homo sapiens family with
GCCCTTCACTCCCACCTGCTGCCAAAGTCCCTG
C5orf6 sequence similarity 53, TGCTAATGGGATTACAA member C (FAM53C), mRNA
57965594 2180 8225 25453892 FAM53C NM 016605
Homo sapiens proteasome
GGGAAGACGACGGAACT (prosome, macropain) 26S GACACCTGAACAGCTGGCAATAAAGAATGTTGG rpn11, PAD1, POH1 TGCCACAGCGACAGACT subuπit, non-ATPase, 14 CAAGCAGGACCCCAAAC TCTCCCAAACAGGAAA
1712 0476 36780728 40107476 PSMD14 NM 005805 (PSMD14), mRNA. ILMN 1674580
Homo sapiens molybdenum CCTGCGCCGGCAACCAC
MOCS1B, MIG11, MOCS1A, CTCTCTGTATAGCCCCGCTATGGGAAAATAAAGT cofactor synthesis 1 (MOCS1), CTAGTGGCCCAGGGAAG KIAA0381, MOCOD GGAGTAGGGGGCATAG transcript variant 4, mRNA GCCGATAATTTAAACA
85660355 154 18095 163 14761 MOCS 1 NM 001075098 ILMN 1666392
Homo sapiens methylenetetrahydrofolate dehydrogenase {NADP+ dependent) 1 , CTTAGTAGGAACGATGAGCACAATGCCTGGACT
MTHFC, MTHFD methenyltetrahydrofolate CCCCACCCGGCCCTGTT cyclohydrolase, formyltetrahydrofolatθ synthetase (MTHFD1), mRNA
13038095 1541 7976 20455476 MTHFD1 NM 005956
Homo sapiens protocadhenn gamma subfamily B, 6 GACTGGCGTTTCTCTCAGGCCCAGAGACCCGGC
PCDH-GAMMA-B6 (PCDHGB6), transcript variant ACCAGCGGCTCCCAAAA L mRNA
1631407 9481847 11801428 PCDHGB6 NM 018926
Homo sapiens chromosome CTCGTGCACATGTGAAG
TGGATCTTTCATCTGAGTTCTTTTTCATGGGCGG
FLJ21802 14 open reading frame 169 TGCCCTCTGAGTTTAAG GTCGGGGTCAGTATCC (C14orf169), mRNA GTTTGGTTAATACTGG
13606429 181 5476 18888095 C14ORF169 NM 024644 ILMN 1719343
pOS + no GFs
Synonyms Probβ_Sβquβncβ Probe_Sequence_l
Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens heterogeneous nuclear πbonucleoprolein A3 pseudogene i (HNRNPA3P1) AGAAGGAGGGTTTCTGG 10 CTGTGGTTCTAAATGGA CACAGAGGGGTCGTGGAGGTGGATCTGGCAATT
HNRPA3, D10S102, FBRNP on chromosome
XRJD00879 XR_001292 GTATGGGTCACAGAGGA XR_001293 XRJ)01294 GccccAGGAAGCTGCc XR_001295 XR_001296 XR_001297
3803733 2757143 34460596 HNRNPA3P1 NR 002726 ILMN_1770035
Homo sapiens MAD2L1 GAGACTTGATAAATCGG
RP1-261G236, CMT2, TCGTGATGGCGGCGCCGGAGGCGGAGGTTCTG binding protein (MAD2L1BP), CCTGAGAAAATAAGTAAT MGC11282, KIAA0110 TCCTCAGCCGCAGTCCCT
117 91428 16506429 172 33511 MAD2L1BP NM 014628 transcript variant 2, mRNA GCTCCAGACTAGCTC
ILMN 1797554
TGGAAGGAGGGTTCTAC
Homo sapiens RAN binding GAGGGGAAGGAAATGGAACAAGTTGTGTTTGTG
RANBPM AGGAACTGGCAGAGCTG protein 9 (RANBP9), mRNA TTAGCATGTGGGTGATG
56 S711B4 217 01846 24964761 RANBP9 NM 005493 AGACTGGGACGCAACC
ILMN 1737663
Homo sapiens coiled-coil-hehx coiled-coil-helix domain TGGAGTGGGGCGAGGAGAGAGCCAGAAAACATA
FLJ20420 containing 3 (CHCHD3), GATCCGAGGGCAGCAGT
434 23096 56083093 58441846 CHCHD3 NM 017812 mRNA
Homo sapiens armadillo TACCCGCCACAGGCACT
MGC10058, MGC4880, CTCCGCCAGGCTGCATTCAAGCTCTATGCCTCT repeat containing 8 (ARMC8), CGGCCCTGATGCCCTCG HSPC056, S863-2 CTTGGAGCAAATGATGA transcript vaπant 2, mRNA TGTCCACTTGTGTCCA
14336429 39868927 44632678 ARMC8 NM 015396 ILMN 1770203
Homo sapiens purinergic
CCCCAAGACCTAAGGGTTTTATCTCCTCCCCTTG
MGC20089, P2X7 receptor P2X, hgand-gated ion AATATGGGTGGCTCTG channel, 7 (P2RX7), mRNA.
87 76892 19901012 217 24762 P2RX7 NM 002562
Homo sapiens mitochondrial
RPML5, PRED66, MGC3400, πbosomal protein L39
CGTCAGCAGGTTCGCTA L39mt, C21orf92, FLJ20451, (MRPL39), nuclear gene GGCATATTGGCGTTCCTGTGCTATGATGATGGG TCAGAAGTCAGCATCAG MGC104174, PRED22, encoding mitochondrial CTGTGTGATAGAGAGGG CAGCTAGAACAGGCCC MSTP003, MRP-L5 protein, transcript variant 1 ,
64653094 10300393 10892434 MRPL39 NM 017446 mRNA ILMN 1680320
MGC125857, AMP, Homo sapiens adenine
AGGTGTGTGGGAACCCC MGC125856, phosphoπbosyltransferase TGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCT AAAAGCAGGGAGGTGCA DKFZp686D13177, (APRT), transcript variant 1, GACCTCGCTTAAGGGCA 5 GAGAGCCATGAAGCTC
1131 8893 4095 147 4844 8057 APRT MGC129961 NM 000485 mRNA ILMN 1782596
Homo sapiens PRP38 pre-
MGC163218. RP11-293A10 1, mRNA processing factor 38 GAAACGTCAGTAGAGTCACACTTTGTGTACAGG MGC41809, FLJ10330 (yeast) domain containing B GATGTCTTAGTGCCCAG
7903133 NM 018061 (PRPF38B), mRNA
12344762 1332976 PRPF38B
Homo sapiens eukaryotic translation elongation factor 1 GTGTCCAGCCCACCGCCTGCCGACTTGTGTCAT
EEF1B, EF1B, EEF1B1 beta 2 (EEF1B2), transcript GCCCTACGTTGGTATAA
61368477 10230447 10951 897 EEF1B2 NM 001959 vaπant 1, mRNA
pOS + no GFs
Probe_Sequence Probe_Sequeπce_l Raw XS pOS + 6 GFs Raw Raw Common Synonyms Genbank Description Probe Id
Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa CAACAGCGATTCAGGAC
CTCGGGAGCCGGTGCTGCCCCCACAGAAGATG
MGC13675, B17, Cl (NDUFB6), nuclear gene CCAAGTGTGAACAACACT GGGCCTATGGAGAAATTC encoding mitochondrial CAGCCCGCCCTCTGG protein, transcript variant 1 , mRNA
921 23926 1067 1976 10899976 NDUFB6 NM_002493 ILMN 1719064
Homo sapiens zinc finger TTGTTGAAGCAGCCACTGGTCCTCTTGTTTCCCC
FLJ31413 protein 746 (ZNF746), mRNA TGCAGACGGAGGGACC
24300595 26675595 272 25595 ZNF746 NM_152557
TM30, MGC3261, TRK, NEM1,
Homo sapiens tropomyosin 3 GCTGCATTTAGATCACC TM30nm, FU41118, OK/SW- CGTGCTCAGGAGCGCCTGGCCACTGCCCTGCAA (TPM3), transcript variant 1 , GTGTGCTCAGGCCAGGT Cl 5, TM-5, TPMsk3, hscp30, AAGCTGGAAGAAGCTGA mRNA GTGAATCCTGAGGTCC MGC14582, TM3, MGC72094
91932263 TPM3 NM_152263 ILMN 1799951
Homo sapiens proteasome
(prosome, macropain) 26S TGCTTGGACTGTCTTTGA
GTACTACAAAGCATCCACAAACATCCAAGACACT p28, dJ889N152 subumt, non-ATPase, 10 ACTCTGCACCTCCTTCCA GAGGGTAACACTCCTC
(PSMD10), transcript variant GGCCATCTTGTGAG
105 180954 437 8393 5153185 PSMD10 NM_002814 1, mRNA ILMNJ 722089
, . GCTTCTCTCAGTCTCTGT
Homo sapiens serum amyloid CTTTGAATATCTGAATGT CAAAGGAGACGGTGGCTCAGGGAGTAAAGGAAG
FLJ41463 A-hke 1 (SAAL1), mRNA GCCAGTTGAGCAAACAG
TCTGGCCCTTCAAC
644 11426 10807393 1147 7393 SAAL1 NM_138421 ILMN 1673503
Homo sapiens proteasome
TGGAGAAGCAGCCAGTGCTAAGCCAGACCGAGG
HsN3, PROS26, HN3 (prosome, macropain) subumt,
CCCGCGACTTAGTAGAA beta type, 4 (PSMB4), mRNA
3173081 3362206 33876895 PSMB4 NM_002796
Homo sapiens F-box protein CCTTTTGACAGGTGTGCACTGTTTTGTCTCCAGT c14_5247, Fbx33 33 (FBXO33), mRNA GAGCACATACCATGCG
43666428 16433225 1892 3477 FBXO33 NM_203301
Homo sapiens solute carrier family 39 (zinc transporter), AGGCTGTGCCCCCGATCCTACACCCTGAGCCTC
ZIP3 member 3 (SLC39A3), AGAGCACTGCTACTΠT transcript variant 1 , mRNA
8839143 984 681 9970976 SLC39A3 NM_144564
Homo sapiens growth factor
MST084, ASH, EGFRBP-GRB2, receptor-bound protein 2 AGCAAACAGCGGCACGATGGGGCCTTTCTTATc MSTP084, Grb3-3 (GRB2), transcript variant 1 , CGAGAGAGTGAGAGCGC
24962262 36620596 38232263 GRB2 NM_002086 mRNA
Homo sapiens chromosome 6 CCCAGGGCAGGTTTGCT
CCTTTTTCTCCAGTATGCTACCTGATTTGTTTGG
MGC19570, dJ34B21 3 open reading frame 130 TGACCTCTGCCTC AGTTC CTGGCCACTAGGTGGC
(C6orf130), mRNA TCGACTCTAAAGGAC
279 06427 35641428 3650893 C6ORF130 NM_145063 ILMN 1807873
Homo sapiens histone GATGCCTTCTGGATCTTA
AGGAACCAAATCAGAACAGCTCAGCAACCCCTG
YAF1, RPD3 deacetylase 2 (HDAC2), AGCCAGTTGTCAGTGGA AATTTGACAGTCTCACC mRNA GGTCCTCAGGGCTGC
3156031 4608 7812 48090894 HDAC2 NM 001527 ILMN 1739496
pOS + no GFs
Synonyms Probe_Sequβnce Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens poly (ADP-
GGAGCCTCTCTCCCTAC
ADPRTL3, PARP-2, ADPRTL2, πbose) polymerase family, CAAGGTAAACATAGCACCAAGGGGCTGGGCAAG TGCTGCTACACAAGACC ADPRT2, pADPRT-2 member 2 (PARP2), transcript
CTGAGACTGACCTGCA ATGGCTCCCAGTTCTGC
201 23929 224 89346 PARP2 NM 001042618 variant 2, mRNA ILMN 1651958
Homo sapiens male-enhanced AGTGGGAAGATGTGGTACAGAAAGCCCTCCAAG
MEA, HYS antigen 1 (MEA1), mRNA cccGGCAGGCATCcccT
1291 1809 1439 8601 MEA1
Homo sapiens reticulon 2
CCAATTTTGGAATTGTCCCCACCTCTGTGGACAG NSP2, NSPL1 (RTN2), transcript variant 1, CCATTGGCTGGGTCCA
117 22262 17589761 186 7143 RTN2 NM 005619 mRNA
Homo sapiens eπdosulfine AAGCACCGGAATGCCAA
MGC4319, MGC78563, CCTCCA GCCTAGGACAAAAGCCTGGAGGCTCCGACTTCC alpha (ENSA), transcript TTAACTAGAGAC MGC8394 TCATGAAGAGACTCCAG variant 8, mRNA GCCCCCAAGGGGAGG
317 3393 553 5143 585 53516 ENSA NM 207168 ILMN 1670272
Homo sapiens protein
MGC52248, FLJ26613, PR55A, phosphatase 2 (formerly 2A), TACAGCTCATTCTTACTGTGGCTTGTAGCATTCC B55A, PR52A regulatory subunit B, alpha TCCTCTTCTGGCCTCC isoform (PPP2R2A), mRNA
78798926 1567 1393 1681 4226 PPP2R2A NM 002717
Homo sapiens Ly1 antibody GGGCCCCTTGATCTGTA
ACACAGTGACAGATGAGCATCACAGATCCGAAG
ZLYAR, FLJ20425 reactive homolog (mouse) AAGGTGTCTTCCACGCT AGGAACTCCTGGTCATC (LYAR), mRNA ATAGTCTCTGGAGGTC
44663513 1094 56 12352769 LYAR NM 017816 ILMN 1710734
GTCATCTCCGTAGCCCT
Homo sapiens F-box protein CCGTCCACCGTGACATGGTTATGCATCCTTTAGA
FLJ10766, KIAA0483, Fbx28 CCCAGTTGTGCCTCCTG 28 (FBXO28), mRNA TTAACCTCACCAAATG CACATTGATGAGTGCC
28923096 3624643 37337262 FBXO28 NM 015176 ILMN 1805930
Homo sapiens »'°n TAAGCCAGGACAAGAAG
AAGTCACTCTTCCCAAAGGCCGACATAAGATCAT
A1. RFC40, MGC3665 SJSSS^T" - CATTCTGGATGAAGCA
GCCAAAATATTCGAGCCGTCCTTATGTGGAA
120 564285 307 08096 34726428 RFC2 NM 181471 mRNA ILMN 1807357
Homo sapiens ring finger and CACCGGGTTCACTGTCC
GACCTGTGCATGGATTGTGCCTTGCAGCTGGAG
KIAA1972 SPRY domain containing 1 TTGTGGGGCTGGAGAGA ACCTGCCCATTGTGTCG (RSPRY1), mRNA TGGGCATAAGTCAGGA
12227144 2909481 32266309 RSPRY1 NM 133368 ILMN 1772233
Homo sapiens mitochondrial ribosomal protein S17 CTCAACATGTGCTTCCCA
CCTGGAGAGTCCGTTGAGTTCGGAAACCACCCA
RPMS17, HSPC011, MRP-S17 (MRPS17), nuclear gene CCTGACCGCAGTCACCA GCTAAGCAAAAATCTGG encoding mitochondrial TTTTCTATGGGACAC protein, mRNA
101461426 1637 406 1739 1726 MRPS17 NM 015969 ILMN 1720756
Homo sapiens fibrillarin (FBL), CGTGGTCGTGGGAGTGTACAGGCCACCCCCCAA
RNU3IP1, FLRN, FIB 10782227 17887686 1935 1477 FBL NM 001436 mRNA GGTGAAGAACTGAAGTT
Homo sapiens phosphatidylinositol glycan
CTCTAGGTAAGACACTTG anchor biosynthesis, class A TGGCCCATGATGCTCTCTTCCACGCCAAGACAAT
GPI3, PIG-A GTAGATGAGAGACGGAA (paroxysmal nocturnal GGGGCTTCAGACAGTC
GGCATTGTCAAGAAC hemoglobinuria) (PIGA),
8 1390505 6553415 67 01494 PIGA NM 002641 transcript variant 1 , mRNA ILMN 1713752
pOS + no GFs
Synonyms Probe Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens inosine triphosphatase (nucleoside
HLC14-06-P, dJ794l63, AGAGGCTGCCAGGACTTTGGCTGGGACCCCTGC triphosphate ITPasβ, C20orf37 TTTCAGCCTGATGGATA pyrophosphatase) (ITPA),
40344345 962 0393 1094 1726 ITPA NM 033453 transcript variant 1 , mRNA. Homo sapiens nudix (nucleoside diphosphate
ASFGF2, gfg-1, FGF-AS, bFGF, GACTCTGTGGCTGAGAGAAGGGCCCAGCAGATT linked moiety X)-type motif 6 FGF2AS, FGF-2, gfg ACCAGGATATGCTTCAC (NUDT6), transcript variant 1,
87 15669 16384763 17978928 NUDT6 NM 007083 mRNA
Homo sapiens HEAT repeat GCATTTCCGCATCCATG
CCACCAAAGATCCTTCCCTTGTGGTAGCAGGAG
FLJ20718 containing 3 (HEATR3), CAAACGAGTCACATATG AAGCTTTGGATGCCCTC mRNA GTGGGACTGGAGCCAT
135 09344 184 4018 19346011 HEATR3 NM 182922 ILMN 1665572
Homo sapiens aspartate beta-
BAHjunctin, CASQ2BP1, TAGGAATCTATGATGCTGATGGTGATGGAGATTT hydroxylase (ASPH), transcript JCTN, HAAH TGATGTGGATGATGCC
21625595 45863928 507 38095 ASPH NM 004318 variant 1 , mRNA
Homo sapiens O- sialoglycoprotein TGTACTGTGCTAGTGACT
GGAGGCCCTGCTACTGC CGTGCTGGCTTGGGCATΠTACATGACATAGAAG endopeptidase-like 1 GCATCCGCTATGAACC
AAATATAAAACCTAA
4249556 10870178 12477261 0SGEPL1 NM 022353 (OSGEPL1), mRNA ILMN 1666904
Homo sapiens mitochondrial translational initiation factor 2
AACCAGGGAGGGCGTGG
(MTIF2), nuclear gene GCTGTGGAAGAGCACCCAGTAGGTGAGGCATCT AAGCTCTGCATCCCTTCT encoding mitochondrial ATACTAGCTACCTTCTC CCCATACCTTGCTCT protein, transcript variant 1 ,
39505597 5887018 618 97266 MTIF2 NM 001005369 mRNA ILMN 1653120
Homo sapiens E2F
TCTGTACATTCTGTAAAA transcription factor 4, AGCCCTGATGATTGGCCCCACCTCCTGCTGCCC
E2F-4 ACTTCAAAACCTGGCCA p107/p130-bιπdιng (E2F4), CATAACCCTCTCTTCAT GGCATGGTGGCTCAC
456 31427 632 256 661 20593 E2F4 NM 001950 mRNA ILMN 1666082
Homo sapiens
GGGCAACTGGTGTGTTT minichromosome maintenance GGACTTCACCAAGCAGAAATACCCGGAGCACGC
MGC5315, CDC46, P1-CDC46 ATATGCCTGACATTATTT complex component 5 CATCCACAAGGTGCTGC GGGTTTTCCCCCCTC (MCM5), mRNA
29545178 93666846 1115 5977 MCM5 NM 006739 ILMN 1667120
Homo sapiens protein phosphatase 1 A (formerly 2C),
PP2CA, PP2C-ALPHA, CGTGGTCATTCTTTGCTGTGTATGATGGGCATGC magnesium-dependent, alpha MGC9201 TGGTTCTCAGGTTGCC isoform (PPM1A), transcript variant 3, mRNA
134 50179 1430731 196881 PPM1A NM 177952
Homo sapiens chromosome
TCCTGTGCTTGGGACCT 14 open reading frame 130 AGGGAAGATTGCCCAGGCCACTGACAGGAGCGA
FLJ10483, MGC9518 GTTTTACTGCTGAGGCTT (C14orf 130). transcript variant CAπCAGTCCTGCCC TCCCCTAATGGATACCC
56989162 12549762 14001428 C14ORF130 NM_001100417 3, mRNA ILMN 1787288
pOS + no GFs
Synonyms Probβ_Sequence Probβ_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe Id
Homo sapiens annexin A8 (ANXA8), mRNA XM_931361 XM_931369 XM_931374 GGCCATCCCAAAGCTATT
GGCCCTTATGTACCCGCCATACAGATACGAAGC
DA301J7 3, ANX8 XM_931375 XM_931378 CTGGGGGCAACAGAGGT
CAAGGAGCTGCATGACG XM_931383 XM_931388 GAAACTACTGGGCCA XM_931391 XM_931399 XM 931404 XM 931411
7 3495235 59093536 B1 198135 ANXAΘ NM 001040084 ILMN 1744914
GGAGCTGCTTCAGTCCA
Homo sapiens zinc finger CTTCTCTTTCTTCACAATGTATGTCCTCAGTGGT
NOA36, HSA6591 . ,,n ,,.,r,,n, OM. TCTCCCAGAGGCATTTG Pro.e,n 330 (ZNF330). mRNA GTCTGTATCTTTGCTC ACCTATTATTGATGcc
12806429 16301845 16971428 ZNF330 NM 014487 ILMN 1770936
CAS, MGC117283, XPO2, Homo sapiens CSE1 CCTGGTGATAGGCCTCG
GGTTCCATCAATGGTGAGCACCAGCCTGAATGC MGC130036, MGC130037, chromosome segregation 1- TCCTCCTGGGTAGAATc AGAAGCGCTCCAGTATC CSE1 like (yeast) (CSE1L), mRNA CTCTCGGAATCACTCC
19304727 3445 7227 3751 2227 CSE1L NM 001316 ILMN 1652490
Homo sapiens DEAD (Asp-Glu helicain B, helicaiπ C, AGAGTTCTGACCAGCAC Ala-Asp) box polypeptide 31 TGCGCGTCAGCCTGGAACGGGCTTGATTGCTGC FLJ13633. FLJ14578, helicaiπ CAGATAAGCTTCAGTGCT (DDX31), transcript variant 1, CCTTAACTGTGTTCTGA A, FLJ23349 CTCCTTTCTTTGGCC
8794475 12386012 131 42262 DDX31 NM 022779 mRNA ILMN 1673191
Homo sapiens adaptor-related
GGCAACACACCAAACTG protein complex 3, sigma 1 AATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCC
CLAPS3 Sιgma3A TCCATCCAGCTCCTCAAC subunit (AP3S1 ), transcript GTGCTGTATCAGCTGTA
TAACGATTTTCAGGC
591 5685 2112 3477 2567 5728 AP3S1 NM 001002924 variant 2, mRNA ILMN 1795275
Homo sapiens cell division CTGTGGGGAGAGAATGA
MGC34109, JP01, FU14736, CTCTGCCAGTCTAGTTTCTGGGCAGGTTTCCTGT cycle associated 7 (CDCA7), CGCATTCATGGAGGTTG FLJ 14722 GTCAGTATTCCCCCTC transcript variant 1 , mRNA AGATGGCTGAAGTCAC
13656409 514 88513 649 1268 CDCA7 NM 031942 ILMN 1719498
Homo sapiens solute carrier family 25 (mitochondrial earner, adenine nucleotide
GTGCCTGGTCCAATGTGCTGAGAGGCATGGGCG
PE02, ANT1 PE03, T1. ANT translocator), member 4 GTGCTTTTGTATTGGTG (SLC25A4), nuclear gene encoding mitochondrial
15946309 68309727 8530 181 SLC25A4 NM 001151 protein, mRNA
Homo sapiens RNA binding AGGCAGGACGGCAGGG
KIAA0765, HRIHFB2091, ATGGCCACAACATTGCCAGCAAATACTGCCTTGG motif protein 12 (RBM12), GTGAGCAGCTTTGGGAG SWAN CATCACTCAGCAGAGG transcript variant 1 , mRNA AGACACCTGGCCTTTTT
13978928 15706429 16248096 RBM12 NM 006047 ILMN 1654032
Homo sapiens spermidine GACCTCCTGCTGGCTCTCGCCCACCAACCAAGT
SRML1, SPDSY, PAPT, SPS1
16374559 17630476 20404309 SRM NM 003132 synthase (SRM) mRNA GTTACAAGCCCCAGAAT
Homo sapiens ribosomal GCGCATCTACAAGCACC
RPL44, MGC72020, MIG6, GAGGAAGTGCGATCGGGAACCTCCTATATACTT protein L36a (RPL36A), CGTTCTACAATCTCTACA L44L CCGTTTGCCTCGCGGTT mRNA CGCTCGACTACGACG
119 23096 172 18512 312 50595 RPL36A NM 021029 ILMN 1770387
Homo sapiens selenophosphate synthetase AACCCCTGGATTGTCCTGGGAAGAGTCACTACC pseudogene (LOC168474) on ACTGTCTGTCAGCCCAG chromosome 7
23 30068 33729633 6606581 LOC168474 NR 002789
pOS + no GFs
Synonyms _ , . Probe Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description - H Probe Id
Homo sapiens ubiquitiπatioπ
UFD2. KIAA0126, UBOX2, GGTGCAAGTGAAGGTGCCAGTTGCTATTTGATAT factor E4A (UFD2 homolog, MGC133315. E4 CACACTCTACAAAAGC yeast) (UBE4A), mRNA
5395143 5590226 5BO 5476 UBE4A NM 004788
Homo sapiens
MGC111163, FLJ13624, oligonudeotide/oligosaccharid CAGCCTGGAGTGAAAATCCTGGGTACTGACTTT FLJ22833, DKFZp667M1322 e-binding fold containing 2A GAGAGGAGTGAGTGTGC (OBFC2A), mRNA
1082 2893 11992976 1450 5642 0BFC2A NMJD01031716
Homo sapiens frataxin (FXN), GTGTAGACTCTCAAGAG
FA, X25, FRDA, FARR, nuclear gene encoding AGCACTTCTGAGCTCTTTAGCATTGAAGTGTCGA
GACTAAAGGTCATATGAA MGC57199, CyaY mitochondrial protein, AAGCAACTCACACGGG
GAATGATGAGAGAAC transcript variant 2, mRNA
37 738613 4443756 59434685 FXN NM_181425 ILMN 1759922
Homo sapiens nucleosome GGAAATTCAGCTTCTCCT
DRLM assembly protein 1-lιke 5 GAGGGAAAGGCCAGCCG ACTTGAAGAACCAATCCAAGTGTGTGCcccTACC (NAP1L5), mRNA GTTTGAGAAGACCTC CCCAGCTCAGAAGTAG
3092393 389 12262 5398893 NM 153757 ILMN 1666781
Homo sapiens peroxisome
PPARB, NUCI, FAAR, PPAR- CAGCTCCGTGTGTGAGA proliferative activated beta, NUC1, NUCII, MGC3931, TGTGCAGG I I I I I I CTAG ACCTACCCAGCTGATGGGGGTTGGGGTGCTTCC receptor, delta (PPARD), NR1C2 GGGGTAGGGGGAGAC TTTCAGGCCAAGGCTAT
158 39345 177 58095 2152976 PPARD NM_006238 transcript variant 1 , mRNA ILMN 1777783
A20, MGC138687, OTUD7C, Homo sapiens tumor necrosis
CCCCAGAGATAAAGGCTGCCATTTTGGGGGTCT TNFA1P2, MGC104522, factor, alpha-induced protein 3 GTACTTATGGCCTGAAA MGC138688 (TNFAIP3), mRNA
181 68097 21600595 352 95593 TNFAIP3 NM_006290
Homo sapiens ubiquitin-like 7
GAACCAGGAGACACGTG
TCBA1, MGC14421, BMSC- (bone marrow stromal cell- AGCTCATCTTTGCTGGAGGAGCCCCATGAACTC TGGCGGGCAGTGGGAC UbP derived) (UBL7), transcript CCTGCTTCCCCTGAACC CCATAGATCTTCTGAAA
29544763 34661847 449 34344 UBL7 NM 201265 variant 2, mRNA ILMN 1775182
FLJ34602, MGC14967, MGC117291, FLJ26141, JLP, Homo sapiens sperm CTGAGGATAGCCAGACC
GCCACAGTCTAATGTCATTCACTTCATTTGATGG HLC4 FLJ13450, PHET, associated antigen 9 CCCCAAACAAGGCTTGA GGTCACTTGTTAGCTG MGC74461, HSS, PIG6, (SPAG9), mRNA. ATAACTCTCCACCCGT
51273926 555 1893 636 3101 SPAG9 FLJ14006, KIAA0516 NM 003971 ILMN 1762631
Homo sapiens glycolipid GTTCTTGAAGTAGTGAAG
CGCCTCACTGCCTTAACCTTAACTGTTCTTCCTG transfer protein (GLTP), ATTCAGGGACTTTATTCT
GCGCTAAAAAGAGCTG mRNA CCCAAGTGTCATGA
34109312 3833 1729 46947144 GLTP NM 016433 ILMN 1677633
Homo sapiens basic leucine AGTGAGGCTGAGATGAC
AAATGGAGCCCTGAGGCATCAGCTATTATACTTG
MST017, MSTP017, HSPC028 zipper and W2 domains 2 AGAGGTGGTCATGGCTG
GGACTCTACCTCTCAC (BZW2), mRNA GCACAGGGCTCAGGTA
2120856 2539 106 BZW2 NM 014038 ILMN 1700994
Homo sapiens small glutamine
ATTCCCACTCCCTTGGTT rich tetratricopeptide repeat CACCTTGGCCCTAAAACAGCCACCAGGAAAGCA hSGT, SGT TTCGCCTGCCCAGCGTT (TPR)-containιng, alpha GCCGGAGAGCCGGACAG GCTGTTTGCGTGGAG (SGTA), mRNA
24226013 27324762 33543512 SGTA NM 003021 ILMN 1747460
Homo sapiens adenylate CGTGGGCTCCAAGTGCC
ADK2 kinase 2 (AK2), transcript TGTGGACATACGAGATC CCATCCCTGTGAGGCAATGGGTGGGAATGATAG variant AK2A, mRNA CAGTTCTCTCAGGACG GACAGGCAAAGAGAAGC
6850559 76067676 921 69763 AK2 NM 001625
pOS + no GFs
Synonyms Qenbank Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Description Probe Id
Homo sapiens ankyππ repeat
GTCTCATTTTCCCAGGGGGTGGGTCATGGGCTC
ANKRD34, DKFZp761F202 domain 34A (ANKRD34A), TAAGCTGCTCTTCTGTC
11329345 127 32262 155 91013 ANKRD34A NM 001039888 mRNA
Homo sapiens pseudogene ACCCCTGCTCTGTGGGA
CTTCTGCCATGATTGTGAGGCCTCCCCAGCCAT MGC10997 (MGC10997) on GAGTGGGGGCTAAGGAA GTGGAACTGTGAATCCA chromosome 15 CAGAAGGATTACCTGC
12674727 1353 5684 15233225 MGC 10997 NR_001565 ILMN 1724709
Homo sapiens mutY homolog
TGGGTTCCAAAAGGTCCCAGGTGTCCTCTCCGT
MGC4416, MYH (E coh) (MUTYH), transcript GCAGTCGGAAAAAGCCC variant gamma2, mRNA
12066012 137 53094 167 19762 MUTYH NM_001048172 GCP-1, MDNCF, NAP1, CXCL8, AMCF-I, TSG-1, TGACCAGGGGACAGCTC
Homo sapiens interleukin 8 CCCAGTCTTGTCATTGCCAGCTGTGTTGGTAGT LYNAP, NAP-1, MONAP, CAGCACCTTGGCACAAG (IL8), mRNA GCTGTGTTGAATTACGG GCP1. SCYB8, LUCT, K60, AGGGAGCAACACTTCC
51528094 89960596 2851 6558 IL8 LECT, 3-10C, b-ENAP, NAF NMJ3005B4 ILMN 1652872
ACTCCCAAGGAGACTTAA
Homo sapiens TSPY-like 1 GAGGCATGGGCCAGGTAAAAATTGGGCCTAGAG
TSPYL GAATGGCAGATGGAGTG (TSPYL1), mRNA TGAAGACTGTGCTGTCG GCCAATGTTGAGCAC
7138684 7984768 9590143 TSPYL1 NM 003309 ILMN 1769734
Homo sapiens nucleolar
MGC20838, NRAP, MGC14921, AAGGCCACTGCAAACCT protein family 6 (RNA- CCCTTGGACATTTACGACGTGCTGATTCGCCTGT bA311H10 1, MGC14896, .,, ,κ,^. =, TGGACAGACTGCTGCTG (NOUλ tπmseπpt GAGGTGCCGCCGTCGA CTCCTCGCCATATCCC UTP22, FLJ21959 associated) variant alpha, mRNA
49850822 62 93331 86781525 N0L6 NM 022917 ILMN 1743100
Homo sapiens 5- GGAGGAAGGCTGCTGG
GAGCCAAGTTCACACCACTGCCATTTCCTCCTGG
5-HT2A, HTR2 hydroxytryptamine (serotonin) GCTGAAGAAGAGGAGCA GCAACAGAGTGAGACC receptor 2A (HTR2A), mRNA GGTCTGGCTATAAGAAG „ ..., ,,„-,,„
55437256 59390594 648 1309 HTR2A NM 000621 / yo/jy
_ .-. GTACAAGGCTTCAAAGTA
Homo sapiens THO complex 4 CCTGTGTGTGTCCCTCAT TGGACATGTCTCTGGACGACATCATTAAACTGAA
ALY, BEF
(THOC4), mRNA GGAGCCACCTGCAG CCGGAGCCAGCGAGGC
63555597 8484768 1302 7935 TH0C4 NM 005782 ILMN_1726415
DKFZp762O2113, RAY1, Homo sapiens suppression of TCTGTGAATCTTGGCTG
GTCTGTGGCACCAGCTAACACGGATCTGAGAGA TSG7, ETS7q FAM4A1, SEN4, tumorigenicity 7 (ST7), GGACTTCCTCTGAGTGA AGCCCTGTCCTCCACTC HELG transcript variant a, mRNA TGCCTGAGGGTCAGCT
10003512 11206012 132 00179 ST7 NM 018412 ILMN 1709750
Homo sapiens mitochondrial πbosomal protein L45 GCCTTATGCCCTTAGGT
CAGACCATGACCGACTTCATACCTTGGTAACTGA
MGC11321 (MRPL45), nuclear gene GCTGAGTTTCATTAAGTA ACACTGTΠTCCAGAC encoding mitochondrial CTGTCACGTTTTCTC protein, mRNA
3154643 342 0851 392 76428 MRPL45 NM 032351 ILMN 1655446
Homo sapiens G protein-
FLJ23091, C1orf139, WLS, EVI, coupled receptor 177 CCTTTGCGGTCCCAGTCCAAGGTAGGCTGGTGT MGC131760, MRP, MGC14878 (GPR177), transcript variant 1, CATAGTCTTCTCACTCC
736 94763 8457143 10438977 GPR177 NM 024911 mRNA
Homo sapiens solute carrier
G6PT3, GSDIb, TRG19, GCATTAGCCTGCATGTTT family 37 (glucose-6- GACTGCTGTTGCCAATACCTCAGACTCCAGGGA PRO0685, G6PT2, GSDId, CTAGGTCTTCTGCCAAGT phosphate transporter), AAGAGAGGAGGCCATCA GSDIc, MGC15729, G6PT1 GCTTTTCTCAGTTG member 4 (SLC37A4), mRNA
171 43927 22630594 35300177 SLC37A4 NM 001467 ILMN 1805645
pOS + no GFs
Probe_Sequβnce Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Si"10"""18 Genbank Description Probe Id
Homo sapiens short-chain
TCCCCTCCTGGGGTCATCCCTCCACTCTGACTCT
FLJ39232, ARPGB36 dehydrogenase/reductase GACTATGGCAGCAGAA
9287685 12569762 19826845 MGC4172 NM 024308 (MGC4172), mRNA
Homo sapiens splicing factor CTGAGAACCAAGGACGC
H1006, SF3B14a. SAP14, CGI- GGGGAACACACCTGAAACTAGAGGAACAGCTTA 3B, 14 kDa subunit (SF3B14), CTGGCTTACAGTGCGCA 110, HSPC175. P14 TGTGGTCTATGAGGACA mRNA GCCAGAAGGAGATGTG
14128643 15220977 17082102 SF3B14 NM 016047 ILMN 1798914
TGTCGTTGGTGGAGAGC
Homo sapiens phosphoseryl- GGCTGGTTGCAGTGTTGCAGAATCGAGAAGAGG
PSTK, C10orf89, MGC35392 GGACAGGCGCCAAAGGC tRNA kinase (PSTK), mRNA CCATTGAGCACGGGGTG CTCTTCCCGGACTTTG
35784462 5586602 9618932 PSTK NM 153336 ILMN 1740494
Homo sapiens immediate early
AACTTGATCTCCATCTTTGGCTCCGGCTTCTCGG
MGC70833, bA247A122 response 5-lιke (IER5L), GGCTGGTGAGCCGACA
40063928 567 1226 9441476 IER5L NM 203434 mRNA
Homo sapiens nbosomal L1
MGC142259, CSIG, L12, PBK1, CCTCAATGCTGCCTCCAGAGCTTTTTGGAAATAC domain containing 1 DKFZP564M182, MGC138433 TCAGATCCTGGCCGCC
10669727 11825559 13543726 RSL1D1 NM 015659 (RSL1D1), mRNA
Homo sapiens heat shock ACAGTACCTGTACCTGCA hsp70, HS24/P52, RY, CACAGCTGTGCCTTCGGATTCAGACAAGAAGCTT 7OkDa protein 4 (HSPA4), CGGTCACCCGCTCCGTG MGC131852, APG-2, hsp70RY CCTGAAATGGACATTG transcript variant 2, mRNA TGTCGCCCTATATTG
16706643 17205476 17794893 HSPA4 NM 198431 ILMN 1724480
Homo sapiens inositol 1 ,4,5-
AGGGCTGAGCTGCGCTTGCGTGGCTGTTTCATG
FLJ36205, IP3R, IP3R3 tπphosphate receptor, type 3 ACCGCTTG I I I M CTCC
54435596 75535596 12078477 ITPR3 NM 002224 (ITPR3), mRNA
Homo sapiens translocase of inner mitochondrial membrane AGGTTTTATGGGAGGCT
PRO1197, TIMM23B, CTGTGATGAAAATCCTGGATGGCTGACCAAGACT 23 homolog (yeast) (TIMM23), GTGCATTGCTCAAAAGCT MGC22767, TIM23 GGCACTTGTTCCAGCC nuclear gene encoding GTTGGGAACGCCTTC mitochondrial protein, mRNA
15073977 16482976 1852281 TIMM23 NM 006327 ILMN 1713759
Homo sapiens cyclin- dependent kinase inhibitor 2C
CCAGTCCTTCTGTCAGTCTCCGATGCCATCATGC
INK4C, p18, p18-INK4C (p18, inhibits CDK4) AGCCTGGTTAGGAGCA
(CDKN2C), transcript variant
16603928 28270593 562 1268 CDKN2C NM 078626 2, mRNA
Homo sapiens menage a trois GCTGGGAAATCACCATG
MAT1. RNF66 homolog 1, cyclin H assembly TGGAAACCAAGCAAACG GCCCAGTTAACCATTTATAAGATTTGGACCTTGG factor (Xenopus laevis) AGCTGAACCAGGGAGC
TGTTGTGCATCAGCCG
3638393 41136847 4830518 MNAT1 NM 002431 (MNAT1), mRNA ILMN 1685854
Homo sapiens chromosome
CTGTTGGGGGGCCTTTGATTTCCTATATCCAGAA
MGC29937 15 open reading frame 40 GTTGAGAGACTTACTC
13218512 14906429 17393929 C15ORF40 NM 144597 (C15orf40), mRNA
FABGL, FABG, dJ1033B109, Homo sapiens hydroxysteroid GATGCTCACGTACCTGT
CCGATGGGACACTTGGGGGACCCTGAGGATGT RING2, H2-KE6, KE6, (17-bβta) dehydrogenase 8 GCTGCATCCTCATGCTTC GGCAGATGTGGTCGCATT D6S2245E, HKE6 (HSD17B8), mRNA TCACCCCCATCATGG
7571889 14685596 HSD17B8 NM 014234 ILMN 1744834
Homo sapiens sorting and
CAGATGTGACCCTACTT
OMP85, TOB55, YNL026W, assembly machinery GTGATGGCGTCCAGTTTGGAGCTGGGATAAGGT GAGGCCGCCTTGGCTTT CGI-51, SAM50, TRG-3 component 50 homolog (S TCCTGTAGCCGACACCC TGGGTCACCCTGTCTC cerevisiae) (SAMM50), mRNA
11238976 11984476 13074976 SAMM50 NM 015380 ILMN 1806500
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l
Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens U2 small
RN, DKFZp313J1712, U2AFBP, nuclear RNA auxiliary factor 1 GCGGGAGCTGTATGGCCGCCGTCGCAAGAAGC U2AF35, RNU2AF1, FP793 (U2AF1 ), transcript variant b, ATAGATCAAGATCCCGAT
5766226 6669976 82919763 U2AF1 NM_001025203 mRNA
Homo sapiens leukotriene B4
CGTCTACCGCTGGCAAGGAGATGCCCGCCAAAA
MGC34943 12-hydroxydehydrogenase AGCTCTGAAGGACTTGC (LTB4DH), mRNA
10187976 12431476 16587393 LTB4DH NM_012212
GTTTGGGATCTTCTCTCC
Homo sapiens calcium binding GCAGTGAGGTCGTAGCCTTTTAGGTGGAAGAAG
FLJ22682, CGI-66, MO25 CACCCACACTTATCTCCC protein 39 (CAB39), mRNA TGAGGGTGCAGCGTGTC CCAGGGCCACTCCA
17769226 1916381 2123281 CAB39 NM_016289 ILMN 1699852
Homo sapiens NSL1, MIND kinetochore complex CAGGGCCTCCTGGAAAA
MIS14, C1orf48, CTGTCCTTAAGTGCCATCAACTCTCAGCTCCCTT component, homolog (S TCATCATCCCTCATCACC DKFZP566O1646, DC8 GTAGCTTTTGTGGGAT cerevisiae) (NSL1 ), transcript CACAGTCGCCCGATT
8652643 98377264 11695476 NSL1 NM_001042549 variant 2, mRNA ILMN 1723709
Homo sapiens regulating ccTCAAGCTCCGGGGAA
RAB3IP3, DKFZp781A0653, synaptic membrane exocytosis AGAAGTGGTCAGGAACAATCATCAGCCCTCCTCT AGGACATTGGAAAGCCC RIM2, KIAA0751, OBOE 2 (RIMS2), transcript variant 2, GGGCGGGAATCAGAGC
ATCGAGAAGGGGCCTA
150491295 33810135 99881546 RIMS2 NM_014677 mRNA ILMN 1696544
Homo sapiens pseudouridylate synthase 1 AAGTACAACCAGCGCTTTGGCAACGATGGGCTG
MLASA, MGC11268
(PUS1), transcript variant 2, CATGAGCCGCTGGACTG
16659344 18194762 1967351 PUS1 NM_001002019 mRNA
Homo sapiens DEAD (Asp-Glu
FLJ30012, E4-DBP, CCCCCAGAAGCCTTAGT
Ala-Asp) box polypeptide 47 ACAGCTTTGCTACTGCGAAATCTTGGCTTCACTG DKFZp564O176, MSTP162, GACCCAGATCTCAACCA
(DDX47), transcript variant 1 , CCATCCCCCTCCATGG HQ0256 GAGACTCAAGATAGCC
59095593 734381 94551013 DDX47 NM_016355 mRNA ILMN 1789999
Homo sapiens coiled-coil
MGC157807, FLJ35632, AAGGAAAAGGTCAGTGCAGTCAGGAGAGACAGG domain containing 4 (CCDC4), MGC 157808, FLJ43965 TCCCGAAAGACGCCCTC
71775536 7294891 80102356 CCDC4 NM_207406 mRNA
Homo sapiens nudix
CTAGGAAGACTACGATTC
(nucleoside diphosphate TCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTT
DIPP1. DIPP CCATCCAGCCCCACGAG linked moiety X)-typθ motif 3 GGATTCTGAAGTGTTCC TCTCGGGCAAGTAGT
56791016 58658093 5981809 NUDT3 NM_006703 (NUDT3), mRNA ILMN 1672538
TACCCCGCAGCAATACG
CPAMD4, FLJ17816, Homo sapiens complement GGAACACCTCCTCAAACCTACCACTCAGGAATGT CACTCTTGGGACCTCGC MGC142298, FLJ17822 component 5 (C5), mRNA TTGCTGGGGCCGAAAG TGATCTAGGATGGGGA
41978256 50885155 6631154 C5 NM_001735 ILMN 1692148
Homo sapiens chromobox
GTGAATTCTTCTAGAGGC
HP1 -GAMMA, HP1Hs-gamma, homolog 3 (HP1 gamma TCCCCCTTCGGATGTGGCTTGAGCTGTAGGCGC TTGTGTACACTACTGGTT HECH homolog, Drosophila) (CBX3), GGAGGGCCGGAGACGCT GTTTTAGTTGGGCC transcript variant 2, mRNA
5939518 6974309 85083093 CBX3 NM_016587 ILMN 1703572
Homo sapiens polymerase (RNA) III (DNA directed) GGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTC
RPC2, FLJ10388 polypeptide B (POLR3B), GGATAAATTTTCCCAAC
37048096 42093927 49174347 P0LR3B NM 018082 mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens met proto- C I I I I CCTTTCTTCAGCC
GTCTCTACCAGGGTCAAGAGCATGAACGCATCA
AUTS9, RCCP2, HGFR oncogene (hepatocyte growth TAACCCGCGGTGGCCCT ATAGAAAGAACTCGGGG factor receptor) (MET), mRNA CGCGGAGTCCGGTCA
21602261 302 3393 4579726 MET NM 000245 ILMN 1765451
Homo sapiens carnitine palmitoyltransferase 1A (liver)
GGAGCACAGTGGATGGC
(CPT1A), nuclear gene GGTTGCTGATGACGGCTATGGTGTGTCGTACAT
CPT1. CPT1-L, L-CPT1 CTTGTGTCCCTCGGGCA encoding mitochondrial CCTTGTGGGAGAGAACC TGACAGGCAGAAACGA protein, transcript variant 2,
10282678 12281845 144 03513 CPT1A NM 001031847 mRNA ILMN_1691487
Homo sapiens formin
GCCTGGAGGTGTGAAGGTGCTGTATCCCGGAAA FHOS homology 2 domain containing TCTATCTGGACCCTGGA 1 (FHOD1), mRNA
616 9976 714 1226 8270643 FHOD1 NM 013241
Homo sapiens tachykinin 3
CTATGAGGGGAGGAGGA
PRO1155, NKB, ZNEUROK1, (neuromedin K, neurokinin TCCTCGGCCCCTTCATCCCAATCAGCTTGGATCC ATGGGAGAGGGGGCTCA NKNB beta) (TAC3), transcript ACAGGAAAGTCTTCCC GGGGCCAATAAACTCT
3522553 51 316242 64 13252 TAC3 NM 001006667 variant 1 , mRNA ILMN 1655039
Homo sapiens ATP synthase, H+ transporting, mitochondrial FO complex, subunit C1
CTCCATGGGGGGTCACCGGCCTGTTGCTACTGC
ATP5G, ATP5A (subunit 9) (ATP5G1), nuclear AACTCCACACCATTCTT gene encoding mitochondrial protein, transcript variant 2, mRNA
1645 5559 2152 306 27876643 ATP5G1 NM 001002027
TTCCTGGAGCAGAACAAT
Homo sapiens PET112-lιke TTCATCCACATCAGGAGGGTCCGGTGAGGCTGC
PET112, HSPC199 TTTTCCCCGAATACAAGA (yeast) (PET112L), mRNA AGCAGTGGTTAAGGAGT ACGCAGAAAGCACG
17356429 19672263 2229851 PET112L NM 004564 ILMN 1707328
GATCACATTGCACGCCT
Homo sapiens juπ D proto- ccccccTCACTTGTCCT GCTACGAGTCCACATTCCTGTTTGTAATCCTTGG oncogene (JUND), mRNA
CCTGATCCTGACACAT TTCGCCCGGTTTTCTG
18901 94 23054 006 27857 047 JUND NM 005354 ILMN 1697519
Homo sapiens ubiqumol-
HSPC151, HSPC051, cytochrome c reductase CCTAGGGTATAGTTCAGGGGTATCCAATCCTTTG HSPC119 complex (72 kD) (UCRC), GCTTCCCTGGGCCATG
17539761 206 3601 241 89761 UCRC NM 013387 transcript variant 1, mRNA
Homo sapiens ribosomal GTCTTTCCGTGGAGCTGTCGCCATGAAGGTCGA protein L24 (RPL24), mRNA GCTGTGCAGTTTTAGCG
1756894 19765 197 22155 14 RPL24 NM 000986
Homo sapiens BUB3 budding uninhibited by benzimidazoles CGCCAAGTGACAGATGCAGAAACAAAACCCAAG
BUB3L, hBUB3 3 homolog (yeast) (BUB3), TCCACCTAATCATCCTG transcript variant 2, mRNA
982 19763 1481 3893 2209 1392 BUB3 NM 001007793
Homo sapiens DEAD (Asp-Glu Ala-Asp) box polypeptide 28
CCTTGAGGGCGGGATGAACTGCTTTGTGACTTG
MDDX28, FLJ11282 (DDX28), nuclear gene
GAAAGGTACGCTGCTGG encoding mitochondrial protein, mRNA
81 63524 10586429 139 09761 DDX28 NM 018380
pOS + no GFs
Synonyms Probe_Sequeπce Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens tRNA-histidine TGCAGAGTGCCATCTGG
GGTGGCTGTAGCATCCCTACCACCCAGGACACT
FU20546, ICF45, FU11601 guanylyltraπsferase 1 -like (S AGGATGCTCACAGGGAG GGTGCGAATGACACAAC cerevisiae) (THG1 L), mRNA GCGGTCACTGGCTTGA
9924762 12894762 165 18094 THG1L NM 017872 ILMN 1798534
Homo sapiens retinoblastoma
TGCAGACATTATATCCATTCCAGTCCTCTGCACT
RBQ3, SWD1 binding protein 5 (RBBP5), 4 56429 GTACACTGCAGCAGTG
14774762 15 157 93094 RBBP5 NM 005057 mRNA
Homo sapiens microspherule
TCACCTGGTCAGAATCCTTGGATGAGCCTGTGG
ICP22BP, P78, MSP58, MCRS2 protein 1 (MCRS1 ), transcript GACCGTTCCTCCTAGCC variant 1 , mRNA
16569345 232 59761 308 19345 MCRS1 NM 006337
Homo sapiens EF-hand AAGAGTCCTCCTCAGAG
CAGCGCAGCAGCCTCGGACCCGGATTGCGTTTG
MGC4342, RP3^I67K163 domain family, member D2 ACCAGGATGGTGGTGAC ccTTAGCGGATATGTTT (EFHD2), mRNA ATTCCTCGTGTCTGCC
11266226 1602 0642 2307 706 EFHD2 NM 024329 ILMN 1680501
Homo sapiens hypothetical CGAGGAAGAAGATGTGG
AGTACACTGGCAACCTGGTCATACAGCTTTTCTT
DKFZp564l2178 protein FLJ20628 (FLJ20628), AGATGAGTGAGGACGCC
GTCAAGTTGAGGAAGG mRNA TACACGGTGCTGACCC
15383511 187 93094 22572263 FLJ20628 ILMN 1708808 p62, SNDI, FLJ43869, IBSN, Homo sapiens nucleoponn GAGAATTTCAACCAGAAA
GCTAACCACCAAGGCAAAGCAGCACAGTGTGAA DKFZp547L134, FLJ20822, 62kDa (NUP62), transcript GAACAGCCAGTGCAAAG TAGAACAGAGCGGGATC MGC841 variant 1 , mRNA GCCCAGAGACAGGAA
262 94345 338 5268 41980597 NUP62 NM 153719 ILMN 1703667
Homo sapiens apolipoprotein
FLJ21201, APOBEC1L, B mRNA editing enzyme, ACCCTTTGGTCCTTCGACGGCGCCAGACCTACT ARCD3, DJ742C192, PHRBNL, catalytic polypeptide-like 3B TGTGCTATGAGGTGGAG ARP4, bK150C2 2 (APOBEC3B), mRNA
99607666 184 90594 350 13095 APOBEC3B NM 004900
Homo sapiens enhancer of
CGCTGGGCCTTCTΠTC zeste homolog 2 (Drosophila) TGCAGTTGCTTCAGTACCCATAATGTATTCTTGG
EZH1, ENX-1, MGC9169, KMT6 CCTCCTGCAACAGAGGC
(EZH2), transcript variant 1, TGCTATGTCCCACAGA TCTCCCCTACAGCAGA
25261665 4928775 114 94768 EZH2 NM 004456 mRNA ILMN 1722282
Homo sapiens ATP-binding
MOATB, EST170205, MRP4, cassette, sub-family C CACACAGCTAACTGCCAAAATACATTGACCGTAG MOAT-B (CFTR/MRP), member 4 TAGCTGTTCAACTCCT
174 03513 21995595 26991846 ABCC4 NM 005845 (ABCC4), mRNA
Homo sapiens scaffold
DKFZp779C1727, SAFB1, HET, GCAGGCCCAGCGATGCCCGCTTCACTCGCCGCT attachment factor B (SAFB), HAP ACTGAGTACTTGGAATC
34483093 360 13095 38487677 SAFB NM 002967 mRNA
Homo sapiens πbosomal AATGGTCGTGCCAAAAAGGGCCGCGGCCACGTG
MGC104292 protein S26 (RPS26), mRNA CAGCCTATTCGCTGCAC
10223314 12736689 16504613 RPS26 NM 001029
Homo sapiens chloride GCCCTGAGCAGCATTTC
CTGTGTCTGGGTACCCTCTGAGTAGGCCTATAAT
CLNS1B. CLCI, ICIn channel, πucleotide-sensitive, CACGGGTGTTTCTTCAG TCCTACCTTGACTGTG 1A (CLNS1A), mRNA AGGACAGTGAGTTCCC
12892059 1422 0559 15859476 CLNS1A NM 001293 ILMN 1713867
Homo sapiens calpain 1 ,
CANPL1, CANP, muCL, AAAGGGGACTCTTCAGGGACTTGTGTACTGGTT (mu/l) large subunit (CAPN1)
14942059 muCANP
15357142 15724976 CAPN1 NM 005186 ATGGGGGTGCCAGAGGC mRNA
pOS + no GFs
Synonyms Probe_Sequeπce Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens sperm CCAGGTCAGAAACCATT
CTGTCAAAATCCAAGCTGCCTTCCGGGGACACA
SP17, SP17-1 autoantigeπic protein 17 GTTCAGAAGACCTCCCT
TAGCCAGAGAGGAGGCA (SPA17), mRNA GTGAGAGAGTTGCTCC
34599762 482 79346 68964343 SPA17 NM 017425 ILMN 1787552
Homo sapiens ATP binding
GGCCCTGCCACCAGAAAGTCGAGCACTGGTCCT
FLJ10349 domain 1 family, member B
AGTCAGGCTGTGATGAA
57858923 62483093 67398096 NM 018066 (ATPBD1B), mRNA
Homo sapiens chromosome
CTCTGTGACTCTATGGTTGACTGCCACCTCTGCA MGC13204, HKMT1188 12 open reading frame 32 ACCTTGACTCATCTGC
279 3476 316 51428 36069763 C12ORF32 NM 031465 (C12orf32), mRNA
Homo sapiens solute carrier family 9 (sodium/hydrogen CACCCCGCCACTGCTCA
GGGGAACCAAGCCTGCTGTGCTTACATCAGCAT
KIAA0267, NHE6 exchanger), member 6 AACTCTCTTGCTCTGATA CTGGAAGACTTTCCTCT
(SLC9A6), transcript variant 1, CCCACTTCAATGGCA
39039764 3895518 39641428 SLC9A6 NM 001042537 mRNA ILMN 1780952
Homo sapiens methylmalonic aciduria (cobalamin
RP11-291L193, FLJ25671, CCTGTGGCGTCAGTCGCAGTGCTCTGGCCAACA deficiency) cblC type, with DKFZp564l122 CTATAGCAGGGCTTATT homocystiπuπa (MMACHC),
77 86545 11350595 17058928 MMACHC NM 015506 mRNA
MGC11225, MGC10775, Homo sapiens MYC CATCTTGAAAGTGAGTG
TGGGTCTGTGCTGACTCTGGCCTTACAACCTTCC MGC34679, MGC36767, orf1, associated factor X (MAX), GTGTCCTTTGGAGGCAT AGCCTCCTTTGCTGGC MGC18164 transcript variant 4, mRNA GGTGGATGAAAGGCGC
10221B44S 11248929 12409761 MAX NM 145114 ILMN 1794349
Homo sapiens mitogen-
MEK3, MKK3, MAPKK3, activated protein kinase CCCCCGGAACCTGGACTCCCGGACCTTCATCAC PRKMK3 kinase 3 (MAP2K3), transcript CATTGGAGACAGAAACT
13976428 188 3601 2705476 NM 002756 variant A, mRNA
Homo sapiens ADP- CCTTAGGCAGGCACCTC
TCTGGGATTATAGGCGTGAGCCACCGTGTCCGG πbosylation factor-like protein CAACCACCACACACTCC CCTGCGTTATTACT (LOC641522), mRNA CTGCTGTTTTCCCTGC
11 887703 27 598335 71 617485 LOC641522 NM 001039083 ILMN 1734827
Homo sapiens transcriptional
ATGGTGGTCTAGCAGCC
FLJ21329, hADA3, ADA3, adaptor 3 (NGG1 homolog, GCATACTAAGTCCCTGGAGAGCCGCATCAAGGA AGGTATCAATCAGCTCTG FU20221 yeast)-lιke (TADA3L), GGAGCTAATTGCCCAGG TTACCACACAAAGGG transcript variant 2, mRNA
3246101 38801428 46851428 TADA3L NM 133480 ILMN 1679542
Homo sapiens PIN2- GTTCTGCGCGGCGGGG
LPTS, MGC8850, FLJ20565, TTCCAAATGAATCCTTCCCAGCCGGGGCCTTCC interacting protein 1 (PINX1), GCCGTACCCGCGGCGGA LPTL GACCACTCAGCTGTCAG mRNA GCGAGGAGGCGAGAATG
72 31564 97 305954 134 5476 PINX1 NM 017884 ILMN 1707099
Homo sapiens RGM domain
FLJ90406, MGC86970, AGGTGACTGCCAACAGCCAGCCCAATGTCGAAT family, member B (RGMB), DRAGON CCAGAAATGCACCACGG transcript variant 2, mRNA
4244354 8054361 16760596 RGMB NM 173670
Homo sapiens family with
CTGTTGGATGTTCATGTG sequence similarity 133, ATCATCTGAGTCCTTGTCAGAATCAGAGTATATT
MGC40405 TTTGAACTTTTGCGCACC member B (FAMI 33B), GAGGAGGTGCGAGCAA
GGATAGACCCCTTG
41036426 46026428 527 79346 FAM133B NM 152789 transcript variant 1 , mRNA ILMN 1679747
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l
Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
GAGCCCCTGGAACTCAT
Homo sapiens neuroligin 1 GATGGAACCAACTTTGTACATCTTGGCCATGTCA
KIAA1070, MGC45115 GGTCTCAGCCTCACACG (NLGN1), mRNA CTGGTCATTGTGTGAA CCAAGGATTACACAGT
5585033 61 69506 71 64295 NLGN1 NM 014932 ILMN 1651404
Homo sapiens splicing factor
TGCCAGCCTCCCAAAGG
SF3A120, SAP114, PRPF21, 3a, subunifl, 12OkDa AGTGCTCCTGTTGCAGGACTGCTGGGAAAACAG
TCTAAGAGGAGAAAAACT PRP21 (SF3A1 ), transcript variant 2, GTGGTGTGGGACTTAAG
GCTTCCAGTGGTTCC
10533929 121 46011 137 11B45 SF3A1 NM 001005409 mRNA ILMN 1709484
Homo sapiens zinc finger
ERF2, ERF-2, TIS11D, GGACTTCAGGAAAAATCAACCCAGCACCAGCAG protein 36, C3H type-like 2 RNF162C, BRF2 CTACCAACCACCATTCC
579 14764 86395593 12174976 2FP36L2 NM 006887 (ZFP36L2), mRNA
Homo sapiens repπmo, TP53
GCTCGTGACTGCACGGTTTACGCCACAAAAGTG
FLJ90327. REPRIMO dependent G2 arrest mediator CTCTTGACATCCGTGAC candidate (RPRM), mRNA
60669327 27 049189 9491589 RPRM NM 019845
Homo sapiens G-πch RNA cccTCAAAGTGTCACAAT sequence binding factor 1 GTATGCTTTCTTTGCCTTGTTCCTGTTCTCAGGG
FLJ13125 „.„_..„ , GCTCCTCCTGATGACTC
(GRSF1 ), transcript variant 2, CTCCCCAGAAAACCA TGACGACTGCCACCAG
1139656 1167 156 11968059 GRSF1 NM 001098477 mRNA ILMN 1723035
Homo sapiens mitochondrial πbosomal protein S22
MRP-S22, RPMS22, GIBT, AGATGGCCAGTCGGCTCAAGGGGCCAAGGATCA (MRPS22), nuclear gene GK002, COXPD5, C3orf5 GGCTGCTGAGGGAATAA encoding mitochondrial protein, mRNA
1287 581 15006934 1722231 MRPS22 NM 020191
Homo sapiens CHMP family, CTGAGCCAGGATGTGCAATAGAAGCAGGGGTTG
MGC29816 member 7 (CHMP7), mRNA TCCCCTCTGCCAGATCT
62 246246 71 12819 81 06526 CHMP7 NM 152272
Homo sapiens chromosome
CGTCACAGCTTTCCTGGGTTGTTGAGCCTCTAAG 18 open reading frame 56 ATGGTCTTTTCCTCTG
50648537 978643 186 53928 C18ORF56 NM 001012716 (C18orf56), mRNA
Homo sapiens guanylate CGTCCTGCGTCTTTTTG
DKFZp686L15228, CCTGATTCTTAAAGGTCATACTTGAAATCCTGCC binding protein 3 (GBP3), GGGAATCCTCGACAGGT DKFZp686E0974, FLJ10961 AATTTTCCCCAAAGGG mRNA GCTGGAAAATTGTGTT
62 22528 84099304 11288609 GBP3 NM 018284 ILMN 1667443
Homo sapiens DEAD (Asp-Glu helicaiπ B, helicain C, GGAGACTGAGCCTGTGG Ala-Asp) box polypeptide 31 GGTTCCCAGCAAACTGAGGCTTGTCTGCCTAGC FLJ13633, FLJ14578, helicain GCGTGGCTTGCTCCCAG (DDX31 ), transcript variant 2, GGCCTTCATCCTTCAGA A, FLJ23349 AGAACCTTATGGAAGA
26742214 47 455154 6900805 DDX31 NM 138620 mRNA ILMN 1785933
Homo sapiens vacuolar
GCATAGAACAACACTACC protein sorting 37 homolog D GC I I I I I GAGGGCAGGTCCTTGTCTTTGTACGTT
WBSCR24, MGC35352 CTCCTCTCTTCCCAGATG (S cerevisiae) (VPS37D), CTGTCCCCAGCCCCGC TGACCACTGAGGGC
21961844 34722263 51966016 VPS37D NM 001077621 mRNA ILMN 1680569
MGC104792, TROB, APRO6, AACGTGGTGAACGTGGC
Homo sapiens transducer of CCAATGGAATGTTCCCAGGTGACAGCCCCCTTA TROB1. PIG49, TOB TGGAGGCTTCAGCCTGC ERBB2, 1 (TOB1), mRNA ACCTCAGTCCTCTCCAG MGC34446 ATCAAGACCCCACACG
251 49762 391 0268 577 98926 TOB1 NM 005749 ILMN 1759732
ELMOD3, FLJ35601, Homo sapiens RNA binding CCTTGCCCACTCCTAGA
GGCCATTCACTTACCCACTCTCTTCTCCCCCTGA MGC111036, RBM29, motif and ELMO/CED-12 GACAGCTGTGCTCACTTT CCCCCGCTCCATTGTT FLJ21977 domain 1 (RBED1), mRNA TCCTGCTTTGTGCCT
71 17618 94 39435 117 189316 RBED1 NM 032213 ILMN 1734476
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens hypothetical
CCTGGCCCAGTACCTTTGGTTTCACAGAAGATCT protein LOC124512 CTGCCAGGCAAGGCCA
44 576775 6262991 8470191 LOC124512 NM 001080510 (LOC124512), mRNA
CGGAGGTGACCAGAAAG
Homo sapiens adenylate CTTGCCTTTTGAGCTCTTGCTACAGTCGCCTTTG
AC3, KIAA0511 ATCTCCATCGGTTGCCC cyclase 3 (ADCY3), mRNA CTACTGCTTTAAGAGA AAGGCTGTAAGTAGTG
10960143 1291 6809 1531 4893 ADCY3 NM 004036 ILMN 1788347
Homo sapiens MAX
GCCTTCAGGGCTGCTCGGAGTCACCTGTTGGAA
MAD3, MGC2383 dimerization protein 3 (MXD3),
TGGACTAAAAGGACCCT
83 16478 10320595 13549345 MXD3 NM 031300 mRNA
Homo sapiens X-ray repair complementing defective
Ku86, KARP1, FLJ39089, repair in Chinese hamster CCAACAAGCAGCTGGGTTAGGAAAACCATGGGT KARP-1, NFIV, KU80, KUB2 cells 5 (double-strand-break AAGGACGGACTCACTTC rejoining, Ku autoantigen, 8OkDa) (XRCC5), mRNA
385 39764 487 63928 5967018 XRCC5 NM 021141
Homo sapiens chromosome TTGGGCTTCTTCCTCCTC
GCCGCGGAGGTATATGGGACAGGTTGCTCATCA
MGC40397 12 open reading frame 45 CATCACCTGAAACACTG ACTCCCAACCTAAGTCC (C12orf45), mRNA GACCTGGGGGTAGCC
12500595 162 74762 1952768 C12ORF45 NM 152318 ILMN 1812262
Homo sapiens solute carrier family 25 (mitochondrial carrier, dicarboxylate CAGATGTGAAGCCTGGA
CCACCTGGGAAGGGCAGTGTGCTCTGTGGGGG
DIC transporter), member 10 GCTTTCCTGATGATGCTG CTGCAATCAATAAATGCC (SLC25A10), nuclear gene GCCCTACAGTACCCC encoding mitochondrial
32914406 84 31038 18665594 SLC25A1O NM 012140 protein, mRNA ILMN 1682514
Homo sapiens coiled-coil CTTGAAGCTGAGAAGGC
CGCCATGTCCGGCCGCGAAGGTGGCAAGAAGA
HSPC016 domain containing 72 ACAGGGCAAGGAGCCAA
AGCCACTGAAACAGCCCA (CCDC72), mRNA GGACCACAGAGCCTCA
42095225 46382393 CCDC72 NM 015933 ILMN 1729767
Homo sapiens RNA (guarane- GTGCCATTGTCTCTCCCT 9- methyltransferase domain _ „ „ GCAAGAGGCTCTGCAATTCGTTCCCAAGAGAAA
FU20432 conta.ning 1 (RG9MTD1 ), AGACTGTTGGCTTCCTG ACATACTGGTTTTCTGG
AGGGCAGGCACTTTG mRNA
401 94345 537 55597 681 34766 RG9MTD1 NM 017819 ILMN 1748891
Homo sapiens zinc finger GTCACAGTGCCTTAGAAGTGGCAGAGGTGAGGG
ZFP219 protein 219 (ZNF219), mRNA TCAAAGAACGGGGTCCC
18989761 331 55594 51745593 ZNF219 NM 016423
Homo sapiens RAP1 , GTP-
MGC118861, MGC118859, GCATGTGATGTTCTAATACCAATTGAAGAACCGC GDP dissociation stimulator 1 GDS1 TGTAGGTACCTCCCTA (RAP1GDS1), mRNA
626881 7059726 7627143 RAP1GDS1 NM 021159
Homo sapiens survival of motor neuron protein GGCTCATTCACTGATTCGGCAGCTTGCAAGAAG
GEMIN2, SIP1 -delta interacting protein 1 (SIP1), GTGCTCTGAAGTGAGGC transcript variant beta, mRNA
3182143 36366428 39699347 SIP1 NM 001009182
KIAA1247, HSULF-2, Homo sapiens sulfatase 2
ATCCCTCGCAGTTGTGGACATΓTCTGTTCCTGTC
MGC126411. FU90554, (SULF2), transcript variant 1 , CAGATACCATTTCTCC
5948646 77 56108 953154 SULF2 DKFZp313E091 NM 018837 mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Gonbaπk Description Probe Id
Homo sapiens TGF beta-
NSA2. HCL-G1, YR-29, GCCACCTTTTGCCTACCAATACTTGGTGTAAAGA inducible nuclear protein 1 CDK1O5 AGAATCccTCATCccc
43224062 4878 5894 NM 014886 (TINP1), mRNA Homo sapiens
PMK, PMKASE, PMKA, CTGAGGGGGTTGGTGGATATTGGGCAAGGCAG phosphomevalonate kinase HUMPMKI GAAACCTCTGGAGACCTC
131 43929 153 18929 16843929 NM 006556 (PMVK), mRNA
Homo sapiens RGM domain
FLJ90406, MGC86970, GTGTCCCGACTAACCACCTCCTTCCGTGTCTTTT family, member B (RGMB), DRAGON CCAACCACAAAACCAC transcript variant 2, mRNA
93 13097 20977261 36063928 RGMB NM 173670
Homo sapiens ribosomal GAACGTGCCATCTGTAAA
GGAAGAAGGAGCTTAATGCCAGGAACAGATTTT
MGC104284, TARBP-B protein L3 (RPL3), transcript GCACTCAGAAGGCAGCC GCAGTTGGTGGGGTCTC variant 2, mRNA ATCCCTAGATGTTGG
32921 37 35538 15 37443 07 RPL3 NM 001033853 ILMN 1727045
TGCCCACGCATGTGGAA
Homo sapiens phospholipase GGACTGAAGCTCCCTGGCTGAAGATACATGCCG
PLCE2, KIAA1092, FLJ13484 GCTAGGTGGGACTCATT C-like 2 (PLCL2), mRNA AGTCAGCACATGGGTAG CCTAATTCTGCCGTTG
19097263 222 97263 251 49762 PLCL2 NM 015184 ILMN_1697218
Homo sapiens SLC2A4 GTAGCAGCAGAGTTGAG
CACAGAGAGGCAGGACGGCAGAGCCATGATTTC
GEF, Sι-1-2, Sl-1-2-19, HDBP1 regulator (SLC2A4RG), CAGTTGTGACAGGAGAC CCACCGAGCGATTACGA mRNA CATGTGGCCTGCAGAG
1297768 168 14761 20033928 SLC2A4RG NM 020062 ILMN 1766544
Homo sapiens mitochondrial ribosomal protein S23 AGCATCTTTCATATGGTA
GAAGTTCCACAGGACCAGCATTTGGAGGCACCT
HSPC329, MRP-S23, CGI-138 (MRPS23), nuclear gene GGAACCAACAAGGAAAC GCAGACCAGTCGAAAGG encoding mitochondrial TTTCCTTTAACTCCC protein, mRNA
385 13095 487 83093 5726393 MRPS23 NM 016070 ILMN 1729019
Homo sapiens acid TGAAGCTCAACACCAAG
AATGTCACCGTCTCCCTCTTCTACCGCAATGACT phosphatase, testicular GTCAGGTAGCCAGGCGG CCGCCCACCTGCCCCT (ACPT), mRNA TGAGGAGTCCAGCACA
60730915 8949367 123 7769 ACPT NM 033068 ILMN 1765954
Homo sapiens RAD51 homolog C (S cerevisiae) CAGCACTGGAACTTCTTGAGCAGGAGCATACCC
MGC104277, RAD51L2 (RAD51 C), transcript variant AGGGCTTCATAATCACC
302 51428 548 18097 80656433 RAD51C NM 002876 2, mRNA
CCCCATGTGCTGCTGAG
Homo sapiens tetraspanin 5 GGCTGTGTGCCCCAGTTTGAGAAGTGGTTGCAG
TSPAN-5, TM4SF9, NET-4 TGGCCAAGATGATGCCA (TSPAN5), mRNA GACAATTTAACCATCGT
GGCTGCCCTATACACT
5196893 869 1726 12107643 TSPAN5 NM 005723 ILMN 1769787
Homo sapiens heal shock
MGC117376, MGC75048, CCACACACTCTTGCAGAGCTTTCAGGTGTTACTC transcription factor 2 (HSF2), MGC156196 AGCTGCATAGTTACGC
105 18929 12009762 131 31012 HSF2 NM 004506 mRNA
Homo sapiens SMT3 suppressor of mif two 3 CATAGTTCTGCCTATTGTCCTTCCCTGAGGCTCC
SMT3H1, SMT3A, SUMO-3 homolog 3 (S cerevisiae) ATTGCTGCTTGGTGGC
31532725 3864481 4434 5557 SUMO3 NM 006936 (SUMO3), mRNA
Homo sapiens arginine/senne-
GCATCCCTACTGCTATCAAGTACCAAGATGACAA
BM-011. MGC12197 πch coiled-coil 1 (RSRC1), TTCCCTGGCCCATCCA
38970596 432 59763 46597678 RSRC1 NM 016625 mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens START domain
CACTGTTCAGATAAGGTCACAATCTGATGCTGTC
GTT1 containing 7 (STARD7), AGTTTGACCGAGCTGG transcript variant 2, mRNA
8759309 1107 8601 13205059 STARD7 NM 139267
Homo sapiens ubiquinol-
CTGAACTGGGTTAGGTGCCGCTGTTGCTGCTCG
MGC111572, QCR6 cytochrome c reductase hinge
TGTTGAATCTAGAACCG protein (UQCRH), mRNA
6340664 7155039 7819965 UQCRH
Homo sapiens mitochondrial πbosomal protein L22
GATCAGCATCATTGGAAC
HSPC158, DKFZp781F1071, (MRPL22), nuclear gene ATAAAATTGTTTATCCTCCACAACTGCCTGGAGA
ATGGGGACGAGTGACGG RPML25, MRP-L25 encoding mitochondrial CAGGAGGACCACGAG ACCTCGGAGACCAGCA protein, transcript variant 1 ,
52540594 68304346 846 98926 MRPL22 NM 014180 mRNA ILMN 1770338
Homo sapiens cleavage and
AGCGTCACAGTGGACGGGAAAACTGCCAACCTT
CPSF, CPSF73, CPSF-73 polyadenylation specific factor AACTTGGAGACACGGAC 3, 73kDa (CPSF3), mRNA
7660893 9488768 11209392 CPSF3 NM 016207
Homo sapiens NudC domain TCACACAAACCCAGTGA
GACTTCAGTGGAGCAGAAATCTCAGGAAACTACA
DKFZp686E10109 containing 2 (NUDCD2), CAGACCCAACGGTGAGG CTAAAGGTGGACCAGA mRNA CAAAGACCGAGCTCTG
234 03513 2964601 3562393 NUDCD2 NM 145266 ILMN 1716680
Homo sapiens chromosome 21 open reading frame 51 TGTAGTTTTCCCCGGCAGGACGGTAGAAGTCGT (C21orf51), transcript variant GGTTTGTGCGCGGCCAG
6843742 99 185135 13244762 C21ORF51 NM 001042401 2, mRNA
Homo sapiens GTP-bindiπg
GGCrrTATTTTCACTGGCCCCTGAGGTTGAAGTC
HSPC135 protein 8 (putative) (GTPBP8), AGAGTCTCCAAAAAAC transcript variant 1 , mRNA
367 4268 407 33093 441 76428 GTPBP8 NM 014170
Homo sapiens chromosome 3
GATGGCGCTCGACCCCGCAGACCAGCATCTCAG
DKFZp779D0833, MGC61571 open reading frame 68 ACATGTCGAAAAAGATG
20526012 3125976 42928094 C3ORF68 NM 182523 (C3orf68), mRNA. Homo sapiens
GTGTGGGGTAGGGCAG methyltransferase 5 domain GAGACACAGGGGAGAATGCCACATGAAGCTGGA
FLJ33979 GGTCCACACTCCTTCCC containing 1 (METT5D1), GGCAGAGATTGGAGTGA ATCCATΠTAGAGGAGG
62607315 74 41977 7909792 METT5D1 NM 152636 mRNA ILMN 1686381
Homo sapiens developmentatly regulated GCCAGTTACCAGATTACACATCCCCAGTGGTGCT
NEDD3, DKFZD434N1827 GTP binding protein 1 TCCTTACTCCAGGACC
1044 2684 1314 1226 15486726 DRG1 NM 004147 (DRG1), mRNA
Homo sapiens TBC1 domain GGTTGCACACCGGAGAG
GGGACATGCACTGGAATAGGAAATGTCCCCCAT
FP2461, DKFZP434P1750 family, member 10B AAACCCTACAAATGTGGA CTCCCTTCCTGCACCCT (TBC1D10B), mRNA GAATGTGGCAAAGCC
116289276 147 4643 17561429 TBC1D10B NM 015527 ILMN 1802053
Homo sapiens protein tyrosine phosphatase-like A domain ATGCAGCAATTGGAGTCACTACGTCACCGGTGC
B-IND1, HSPC121, FLJ90376 containing 1 (PTPLAD1), TGCCTTCTCTGATCCAG
12104226 16258977 2010 1809 PTPLAD1 NM 016395 mRNA
pOS ♦ no GFs
Synonyms Probβ_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe Id
MGC34679, MGC36767, Homo sapiens MYC
CTTTGTTCCTGGGGAATTCACTTCTCTTCCTCCC MGC11225, MGC10775, orfl, associated factor X (MAX), TCATGGAAGATGCAAG MGC 18164 transcript variant 3, mRNA
9 127583 41 544678 6842629 MAX NM 145113
Homo sapiens nbosomal pp90RSK2, MAPKAPK1B, CLS, CTGCAGAAGGAGTCGGC protein S6 kinase, 9OkDa, GTACTTATTTTGCATTTTTGGTCATGGGTGGGAA RSK2, RSK, S6K-alpha3, p90- GTATGGAGTCTCGAACC polypeptide 3 (RPS6KA3), TGGGGTGGGTGCCTAC RSK2, ISPK-1, MRX19, HU-3
71 44855 97 7227 12052261 RPS6KA3 NM 004586 mRNA " C"GA1^GGAT . T .T . ~GT .C v-T ■ *G~CwC |LMNJ 725471
Homo sapiens CUB domain
GCGGGGAACTTCAACCTCTCTCTGCAAGGCTGT
SIMA135, TRASK, CD318 containing protein 1 (CDCP1), GACCAAGATGCCCAAAG transcript variant 2, mRNA
26263805 99731186 265 7143 CDCP1 NM 178181
Homo sapiens DEAD (Asp-Glu CCTCATAGGGACTTTGC
DKFZp564O176, FLJ30012, E4- Ala-Asp box polypeptide 47 CTCCTGACAGCAGTTTAT GCC I I I I I IAGCTGCAAGTCAAGGACTAGGTTGA DBP, MSTP162, HQ0256 (DDX47), transcript variant 2, TGATGCCCATGACCTG
GGGTGTTCATTGTGG
1840 1477 21504934 2388331 DDX47 NM 201224 mRNA ILMN 1724789
Homo sapiens transmembrane GAGGCTTGCTCCTATGGCTCCATTCCTGTGGTG
HP10481 protein 5 (TMEM5), mRNA GAAGACGTGATGACAGC
17852559 24372893 TMEM5 NM 014254
Homo sapiens mitogen-
GCAGCGACAACCCGTCC activated protein kinase AAGAATAGCACCCCCTTCCCCATTGCCCCAGCTT
FTDCR1B, HSNIK, HS, NIK TCTCCCGAG I I 1 1 I CATA kinase kinase 14 (MAP3K14), AGCCTCTTCTCCCAGG ACTGAGCCCACTCGC
45807354 8472783 11649763 MAP3K14 NM 003954 mRNA ILMN 1719543
Homo sapiens eukaryotic
CAGGGGAATCCACACAG
EIF2A, EIF-2A, EIF2, EIF-2, EIF translation initiation factor 2, CTGTTGATTAAGGGGAGGTCCAAGCATTTGTACT CCCGCTCCCAGGAGCTA 2alpha subunit 1 alpha, 35kDa TGGCAGGAATGCTGGC ATGGTAGAGCGTCCTT
20372263 222 41846 23066013 EIF2S1 NM 004094 (EIF2S1), mRNA ILMN 1728724
Homo sapiens secretory GACGTTTCCATCAGGTTC
AGCTTCCAGCAGGCCCAGGAGGAGTTTTCCCAG carrier membrane protein 2 CATCCCGAAAATCTCTCG GGCATCTTCAGCAGCAG (SCAMP2), mRNA GTTCCACGTCCCCC
8333174 16034763 197 57262 SCAMP2 NM 005697 ILMN 1804922
Homo sapiens Ts translation CCCTTTGTACCAGATGTT
TCCCTGGACGATGAGCCTGGGGGAGAGGCAGA
EF-TS, COXPD3, EF-Tsmt elongation factor, GAGTGACCAGCTCTGTG GACTAAGATGCTGTCCCA mitochondrial (TSFM), mRNA GCCCTGTGTCGTCAG
142 58511 1822768 19881012 TSFM NM 005726 ILMN 1689989
Homo sapiens peptidylprolyl isomerase (cyclophιlιn)-lιke 5 GCTGCAAGCACCATTAACTTTATTGGAATCTTCT
MGC20689, 4-1 BBLRR, LRR-1 (PPIL5), transcript variant 1, GCACGAACCATATTAC
14431595 39072433 6051908 PPIL5 NM 152329 mRNA
Homo sapiens cryslalliπ, zeta GCAGCCTTGGATCTTTCT
TTGGATCCTCCAGATAGCCACTGCCTTTTCCTCA
QOH-1. 4P11 (quinone reductase)-lιke 1 CATACCCAAAACATTGGA AGGGAGCAACGTTAGC (CRYZL1), mRNA CAGATGCTGCGTAC
549 57263 789 5143 941 11426 CRYZL1 NM 145858 ILMN 1748923
Homo sapiens ubiquitin TGATAGGCCCAGAAGCC
GATCAACCAGTACCAGGTGGTGAAACCAACTGC
MGC2621, UBPO, KIAA0190 specific peptidase 10 CATGTTAGTTAGGGGAA TGAACGCACAGCCTACC (USP10), mRNA GGGAGCAGGAAGAGGG
2492768 3189643 36078094 USP10 NM_005153 ILMN 1725969
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens NFS1 nitrogen fixation 1 homolog (S GCTGCTGAAGTAGTGTTT
ATGGCTGGGAGAGTGAGGCAGCCATGGAACGT
IscS, NIFS, HUSSY-08 cerevisiae) (NFS1 ), nuclear AGGATCCTCCATGGCAG GCTCGTCAGCAAGTAGCA gene encoding mitochondrial TTAGTGAATGTAAGA protein, mRNA
59501015 17570595 297 94345 NFS1 NM 021100 ILMN 1694491
Homo sapiens eukaryotic translation initiation factor 2B, GAGTGTTGCTGCTGAAGCACATCCTTGCAATGT
EIF-2Bbeta, EIF2B subunit 2 beta, 39kDa GGGAGTGCACAGGAGTC
1107 5559 16090143 1907 4226 EIF2B2 NM 014239 (EIF2B2), mRNA
Homo sapiens family with CCATGGGAAACAGGTGG
DJ347H134, D15Wsu75e, GGCACAGTTCCTGACTGGGCGGAAGATTCCTTC sequence similarity 152, AGATGGGGAAGCCGTCT MGC 138384 TTACATCACAGACCTGC member B (FAM152B), mRNA CTTCTGCATGGTTTAT
101848096 12000559 1297 3643 FAM152B NM 015704 ILMN 1799104
Homo sapiens threonine GGGCAGGATCCCTGGAC
TCAGCAGGATTTTGTAGCTGACTGGTGCTCTGA
FLJ22002, TSH1 synthase-like 1 (S cerevisiae) ACTTACGTACAATGCTTC GGGAGAGTGCCTAGCAG (THNSL1), mRNA GTGCTGCCTGATGAC
29 577679 53728767 68 31653 THNSL1 NM 024838 ILMN 1750785
Homo sapiens ubiquitin specific peptidase 14 (tRNA- GCTGCTCCGGGACCGCT
TCCTGAATGTGCCTTATATGCTGTGCCACTCACA
TGT guaniπe transglycosylase) TGGTATTGGGCAAGGCC CCGAGGCCATCATCTC (USP14), transcript variant 2, TACTCATACTCTGCTA
10597262 123030945 132 17262 USP14 NM 001037334 mRNA ILMN 1726880
Homo sapiens eukaryotic
EIF3-P116, MGC131875, EIF3- I I 1 1 1 1 GAGACAGAGTCT translation initiation factor 3, CCCACCGTGCAGGTTGTGGCCGGTTTTCTCCGC P110, EIF3S9, PRT1, CACTCCAGCCTGGGTGA subunit B (EIF3B), transcript AGGTTGAACATGGAAAT MGC104664, EIF3-ETA, elF3b NM 001037283 CAGAGCAAGACTCCG
45533394 5298048 5703706 EIF3B variant 2, mRNA ILMN 1814204 Homo sapiens ATPase, H+
CTGGCCAGCTTGGTGCT
VA68, Vma1, HO68, transporting, lysosomal GATGATGCAGTTCTGTATTTATTGTGCTGTGTCT CACAGCTGCTGGGTAAG ATP6V1A1, VPP2, ATP6A1 7OkDa, V1 subunit A GGTCCTAAGTGGAGCC CTCTTGCCTAAGGAGC
1442 5143 1877 3226 21105142 ATP6V1A NM 001690 (ATP6V1A), mRNA ILMN 1789455
Homo sapiens DIP2 disco-
ATACTAAATCCAGAGGG interacting protein 2 homolog GAGGTGTGCTGCTTGTCAGCATGTATTGTCACG
DIP2, C21orf106 GGATGTCAACTCTGCCA A (Drosophila) (DIP2A), GACACTCAATAAGTGCC AAGTCTGTGCCCACAT transcript variant 1 , mRNA
7763964 83456055 8922834 DIP2A NM 015151 ILMN 1701229
Homo sapiens proteasome (prosome, macropaiπ)
PA28-gamma, Ki, PA28G, REG- TGAACTGGTTCAAGGCGCGTCCTACCCAGTCAT activator subunit 3 (PA28 GAMMA TTTCTTTACCTTATACT gamma, Ki) (PSME3),
7632643 9146226 991 97266 PSME3 transcript variant 1 , mRNA Homo sapiens hepatoma-
CGTCTGATTTATGAAGCT derived growth factor (high- GTGCTCTCCATTCTGCTCCTTCCCCATCGTTGCC
DKFZp686J1764, HMG1L2 CCCCATCCACCTATCTGA mobility group protein 1 -like) CCCATTTCTGAGGTGC GTACCTGACTTCTC
15865227 1702 5894 1764 131 HDGF NM 004494 (HDGF), mRNA ILMN 1674984
Homo sapiens kiπesiπ light GCATGCGTGTGCAGGAC
KLC1. KLC, KNS2, KNS2A. GCTCGGACTCCGGGTCTCCCTAGGATATGCCCC chain 1 (KLC1 ), transcript TGGCTGTGTGCTTGGAC MGC15245 AGTAGCATTTGCTGTGT variant 1 , mRNA
472 7101 5359226 57003094 KLC1 TCGGCTCCAGGTGGAA
NM 005552 ILMN 1783753
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
GCAGACATCCCTCCCAA
TIP49B, TIP48, TIH2, RVB2, Homo sapiens RuvB-like 2 (E GAGGAGGGCAAGGCGGAGATCATCCCTGGAGT TCTTGCCCACACACTGA CGI-46, ECP51 coll) (RUVBL2), mRNA. GCTGTTCATCGACGAGGT
GAAGTAACTCGGAGCT
9766809 1291 606 1491 381 RUVBL2 NM 006666 ILMN 1673544
Homo sapiens BCL2- TCCCTGCCCAGCAAGAA assoαated X protein (BAX), TCAGAACCATCATGGGCTGGACATTGGACTTCCT
GCAGTATCGACTCAGCA transcript variant Sigma, CCGGGAGCGGCTGTTG TGGAACGCCTGCAACG
18003977 3486 5562 4846831 BAX NM 138765 mRNA ILMN 1684919
Homo sapiens ubiquitin
GCAACATCCTAATTGGCTCAGTGCACGTTTGGCA
UCH37, CGI-70 carboxyl-terminal hydrolase LS ATAGTGCCAGCCTGTC
354 32263 671 25183 91661426 UCHL5 NM 015984 (UCHL5), mRNA
Homo sapiens Tclβxi domain
AGAGGTGAAGGAGTATTCATGGCTTCTCGCTGTT
MGC33212 containing 2 (TCTEX1D2), TCTGGGATGCTGACAC
896 94763 1556 7559 20433228 TCTEX1D2 NM 152773 mRNA
Homo sapiens solute carrier
ZnT-5, MGC5499, ZTL1, family 30 (zinc transporter), GTACAGAAACAGAGTTCCCTACTACTGGATCAAG FLJ12496, ZNTL1, FLJ12756, member 5 (SLC30A5), GAATCTTTCTTGAAGG ZNT5 transcript variant 1 , mRNA
91 38513 SLC30A5 NM 022902
Homo sapiens chromosome CTTTGCTCTTCCTGTTTT
GCCTGCTGCTTTTCCTTTTGAAGGACACAAACCT
FLJ22851, MGC11326, HH114 15 open reading frame 41 TGGTGCCTGTTCCAGGT GGTCCCAACATGTGTG (C15orf41), mRNA CATGGAGGAATCATA
9821846 149 82678 177 98929 C15ORF41 NM 032499 ILMN 1684308
Homo sapiens dystrophin
DXS272, DXS269, DXS230, (muscular dystrophy, CAAATCTTTCCTGGCGAA DXS268, DXS27O, DXS239, CCATTCAGAAGAATGATAAATGCCACAAGCATTT
Duchenne and Becker types) GGGGAGGGAAGGGGTG DXS142, DXS206, CMD3B, GGAAACAGGCTTCCCT
(DMD), transcript variant TTCTGGTGGAGTGGGA DXS164, BMD
35061398 8086612 118680954 DMD NM 004010 Dp427p2, mRNA. ILMN_1786361
Homo sapiens chromosome 1 open reading frame 103 CCCAGCTTGCTTCCATGGCCAATCTAAGGGCAG
RIF1, FLJ11269, RP11-96K19 1
(C1orf103), transcript variant AGAAGAATAAAGTGGAG
21 830338 51 64456 7834192 C1ORF103 NM 018372 1, mRNA
Homo sapiens DEAH (Asp-Glu
KIAA0890, FLJ11214, ReI-CoR, Ala-His) box polypeptide 30 AGCTGGCTGCACTTCCCCCCAGCGTACAGGAGG DDX30 (DHX30), transcript variant 2, AGCACGGGCAGCTGCTT
158 11429 202 05179 230 10596 DHX30 NM 014966 mRNA
Homo sapiens chromosome 8 CCCTGTGCAAATCAGAG
GACCGCCGTTCTCAAGGACGGGTAAAGGGTCTC
FU23263 open reading frame 41 TATGTGAGTGGAAGAAG CTGGCCAAAATTCCCCA (C8orf41), mRNA GGGTGAGTCCTAACTG
17340594 221 56012 256 3851 C8ORF41 NM 025115 ILMN 1691693
Homo sapiens XTP3-
AGGGGTGCCTCTGAGACCCATTCTCGTGTTTCC
RS21C6, CDA03, MGC5627 transactivated protein A CTGTTGTACCTTTTGCC
7067143 1131 3893 1462 6809 XTP3TPA NM 024096 (XTP3TPA), mRNA
Homo sapiens legumain CCCAGCAGGGCCAGGTC
TGGCACAATCTTGGCTCACTGCAACCTCTGCCTC
AEP, LGMN1, PRSC1 (LGMN), transcript vanant 2, GGAAGGTGATTGAATAC CCGGGTTCAAGCAATT mRNA AAAAGCACCAGGGACC
11 402901 72201614 229 13097 LGMN NM 001008530 ILMN 1804444
Homo sapiens chromosome
TAKL-2, TAKU, TAKL-1, GTGACCTCACAGTAAACATCTCTGCCTTTGCCTG 21 open reading frame 7 HC21ORF7, TAKL TGTGTGTTCTGGGGGA
10095239 139 13928 16578513 C21ORF7 NM 020152 (C21orf7), mRNA
pOS + no GFs
Synonyms Probβ_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
GCTAAAGAATAAGACCTT
Homo sapiens SFRS protein
GCTTGAGAAGGCTGACC GGCAGCTGTAGATCTTGATCTTCCAGGTACCCC
SFRSK1 kinase 1 (SRPK1 ), mRNA ATGTACCTTTATTGAGC TGGACCCCTCCCTGG
48438095 706 5643 851 9976 SRPK1 NM 003137 ILMN 1659985
Homo sapiens cleavage
CCACAGTGTGTGGCGCT
MGC75122, MGC43001, stimulation factor, 3' pre-RNA, GTGGCAGAACCACATTTTGTTCCCTCTTCAAGGG
GATGGAGATGTCAGAAC MGC117398, CSTF-77 subunit 3, 77kDa (CSTF3), TGTCTTGTATGTGCCG
CGAGAACACTTAACCT transcript variant 1 , mRNA
4282976 591 48096 6959976 CSTF3 NM 001326 ILMN 1658149
Homo sapiens glutamyl-
MGC129938, FLJ37000, IRNA(GIn) amidotransferase, GAATTACTACAAAACTCCCATCGCGTCGTGGAG 15E1 2 subunit C homolog (bacterial) GAGTACTTTGTGGCCCC (GATC), mRNA
81 127106 11342678 13653928 GATC NM 176818
Homo sapiens N- CTCACTGTACTGGCCCC
GTCACAGCTCTGTCTGTTGCCCCAGAATTTCGAC dJ1002M8 1, NAT3 acetyltransferase 5 (NAT5), CAATGGCTTCTACATGC GCCTTGGTTTGGCTGC transcript variant 3, mRNA GAGCCGACCAAAGTGG
1195 1809 15450476 17465393 NAT5 NM 181528 ILMN 1689635
MGC141879, MGC141878, Homo sapiens protein inhibitor TGGGCCAGGACTGCTCT
CTGCCAACCACCAATGGAAGCAGTAGTGGCAGT GU/RH-II, GBP, ZMIZ3, of activated STAT, 1 (PIAS1 ), GAGATTTGAGGGAAACA AACAGCAGCCTGGTTTC DDXBP1 mRNA TGGACCCTTTTGGCCC
35056012 3944851 41832678 PIAS1 NM 016166 ILMN 1804652
Homo sapiens proteasome GCATTATTGTGACAGCCA
GCTGAATGCTGTGGACCGGGATGCAGTGTCAGG
HC10-II, MGC4147 (prosome, macropain) subunit, CGAACCCATTGCCCACA CATGGGAGTCATTGTCC beta type, 3 (PSMB3), mRNA ACCCCTCCACCCTCG
3481 7642 3877 056 4115 556 PSMB3 NM 002795 ILMN 1769665
Homo sapiens GCCTGGTGTGCTGCGCC
CACGGTGTCACTTTCCATGGGTTCAGTTATCTGC
CARKL, FLJ32478, SHK sedoheptulokinase (SHPK), TATCCGCCGGGAGCCTT GGTCAACCACGGTCTG mRNA TGTGTCCGTGTCCCGA
258 15594 381 31012 482 16428 SHPK NM 013276 ILMN 1769822
Homo sapiens Hermansky-
SUTAL, DKFZp686F0413, GCCGGCCTCAGTGTCCATGTTCTGTGTCGTACA Pudlak syndrome 3 (HPS3), FLJ22704 CGCTTGAAAGAGTATGA
12442678 14566428 15968927 HPS3 NM 032383 mRNA
Homo sapiens brain-derived
CTTGCTGTGGTCTCTTTGTGGCAGAAGTGTTTCA
MGC34632 neurotrophic factor (BDNF), TGCATGGCAGCAGGCC transcript variant 4, mRNA
275 38928 4182726 55240594 BDNF NM 001709
Homo sapiens 5- amιπoιmιdazole-4- CTCGCTATGACAGTGGA
PURH, IMPCHASE, AICARFT, CGTAGACAGAGCTAAAAGGAGTGGTGTGGCGTA carboxamide ribonucleotide CAGGACCTAGATGAGGA AICAR CATTGCGGCTCCCTCCG formyltransferase/IMP GGGCATGAATATGGGT cyclohydrolase (ATIC), mRNA
37196812 4091 8018 4318756 ATIC NM 004044 ILMN 1663616
Homo sapiens small nucleolar CCTGCTTACAAATGTCTA
MGC16362, U50HG, RNA host gene non-protein ,,-rτrrr-rΔrτr-rrτrr GTCTGGGCGGGTGGTAGGAACAATGGCGCTGT DA33E242, C6orf160 coding) 5 (SNHG5) on AGGTCCCCACTGCCTGC CTTCAGTGGCACAGTGGA
TGGAGAGAAAACACA chromosome 6
6640664 7340506 78095557 SNHG5 NR_003038 ILMN 1691803
pOS + no GFs
Synonyms Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probβ.Sequencβ pmbeJd
Homo sap,ens tumor necrosis TGTACATACGGCCCACAT factor recep or suPerfam,ly, CTGATCGCTCCCCWG ATAGGTCCAATCTGCTCTCAAGGCCTTGGTCCTG
MGC31965, BM-018, DR6 member 21 (TNFRSF21), rΛπ-iriΛrι-τrττr GTGGGATTCCTTCACC
85360596 12654309 16570476 TNFRSF21 NM_014452 mRNA CAGGACAAGCTGGTG
MGC118790. DEPC-1, Homo sapiens alkB, alkylation CTTTCAGCTCAAGAGCCA
AGAGAACCGAGAGTGAACCTGACCTTTCGGACA MGC118792, MGC118793, repair homolog 3 (E coll) GAAGCGCTATCACGAAG GTCTATCCAGACCCTCG PCA1, ABH3, DEPC1 (ALKBH3), mRNA ATATCTTTGGTGCTG
43962262 522 9143 57940594 ALKBH3 NMJ39178 ILMN 1747882
Homo sapiens mitochondrial πbosomal protein L21
GCTGTCCTGTTCTCCATC
(MRPL21), nuclear gene GACCTTGCGTGTGGAGAGAGAATTCGACTGGAG
MGC62013 TCCATTTCTTCCCATGCT encoding mitochondrial AAGGTCCTGCTGGTTGG
GTAACCCCAGGCTC protein, transcript variant 1 ,
16774727 19044559 20822642 MRPL21 NNM81515 mRNA ILMN_1680782
Homo sapiens proteasome
(prosome, macropain)
PA28-gamma, Ki, PA28G, REG- TCCTTCCCGAGTGATACCCATGAACTGCCAGTAG activator subunit 3 (PA28 GAMMA AGGCTGCTATCGTTCC gamma, Ki) (PSME3),
751 44763 9302726 10376685 PSME3 NM_005789 transcript variant 1 , mRNA
Homo sapiens tyrosine 3- monooxygenase/tryptophan 5- GAAACTGAGCTGGGACT
CATGCAGATTTGTGCACATGTGAGAGGGTGTCC
HS1, 14-3-3, 1C5 monooxygenase activation GGAAAGGACAGCCCTTG
AGTTTGTCTAGTGATTG protein, theta polypeptide ACCTGGGTTCTGGGTA (YWHAQ), mRNA
9695331 13327 147 16151 356 YWHAQ NM_006826 ILMN 1707342
Homo sapiens endo-beta-N-
TTGTGGGGGGCGCAGCATCCACGCCTTGCTGCC
DKFZp434P174 acetylglucosamimdase CTTCTTTCATGAAGTCT
4940931 56 330696 62008263 FU21865 NM_022759 (FLJ21865), mRNA
Homo sapiens bromodomain GTTCCAGAGGTTGGACTTGTATTAGGTAATAAAG
CELTIX1, NAG4, BP75 containing 7 (BRD7), mRNA
802 10596 8982851 95883093 BRD7 NM_013263 CTGGACCTGGGACTCG
Homo sapiens glutathione CATGGGGTTTCTCCATGTTGGTCAGGCTGGTCT MGC78522
5042256 118 52679 19492679 GSR NM 000637 reductase (GSR), mRNA CAAACTCCCACCTTCAG
Rrp41p, p12A, FLJ20591, Homo sapiens exosome
GCAGGTGCTACAGGCAGATGGTGGGACCTATGC hRrp41p, Skι6p, RRP41A, SKI6, component 4 (EXOSC4),
3280476 398 93512 45701428 EX0SC4 AGCTTGTGTGAATGCAG
RRP41 NM 019037 mRNA
Homo sapiens ecσtropic viral GGGACACTACCACAAGC
EVI-1, PRDM3, MGC163392, CCAGGGCTGCGGCGGAATCCAGTGCTATCCAGT integration site 1 (EVI1), CCCTTCTGGAAAGGATG MDS1-EVI1, AML1-EVI-1 CCATAAGCCACGTATGA mRNA
41 459953 114 1893 203 28513 EVM NM_005241 CAGAAAAGACCCCAGC
ILMN 1745021
Homo sapiens cornichon
CNIH1. CNIL, TGAM77, CTTTGTGCAGCAGAGTGGCTTACACTGGGTCTC homolog (Drosophtla) (CNIH), MGC117156
14756643 1705 1643 18607227 CNIH AATATGCCCCTCTTGGC NM_005776 mRNA
Homo sapiens ribosomal
ATGTGTGCTGGCAATCA protein S6 kinase, 9OkDa, GGCCCTGGGGGACCCTCTGAAGCATTTCTGCCT
RSK-B, MSK2 GGGCCGCAGTGTGTTCT polypeptide 4 (RPS6KA4), CACTTTATGTCATCTGC GCGCCTGCCCAGAGCT
52328516 6730476 7804393 RPS6KA4 NM_001006944 transcript variant 2, mRNA ILMN 1771651
Homo sapiens EGF-like,
GAGGACATGCCTCCCAC fibronectin type ill and laminin GGCCCTTGGATTGTTCGGATTAACCCCTTCCACT
AGRINL, AGRNL, FLJ39155 CAAATGTCCCCTGCTCCA G domains (EGFLAM), CCTCACTGGCTGGTTC GTCCCACTCCTGTCA
41 199665 6563173 8696097 EGFLAM transcript variant 4, mRNA. NM 182801
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence__l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens cytoskβleton CCCAACATGGAGCTGTG
KIAA0097, TOG, TOGp, CGATGAGGTCCTGAGACAGGAAGACAAAGCTGA associated protein 5 (CKAP5), CAGGGACATCCCGCAGT FLJ35359, ch-TOG AGCCATGTCCGGCCATA
NM 001008938 transcript variant 1, mRNA TGAAGCTGGTGAACGA |LMN
106 53929 151 86845 18598929 CKAP5
H2A y, H2A/y, H2AF12M, Homo sapiens H2A histone
GACAGTGATGCTGTCGTTCACCCGACAAACACT MACROH2A1 1, mH2A1, family, member Y (H2AFY),
GACTTCTACATCGGTGG
11242643 1624 1809 19857476 H2AFY macroH2A1 2, H2AFJ NM 138609 transcript variant 1, mRNA
Homo sapiens armadillo TAGACAGGGGCTTGCTA
GCACGGATGTTACTGTCCTGCTCCTTCCCCCAG
R30923_1, MGC 19595 repeat containing 6 (ARMC6), TAGTGTCCAGGCTGGTC CCCCACGCCCTACCAGA mRNA TGAAACCCTTGAGCTC
13227261 1692143 1939643 ARMC6 NM 033415 ILMN 1704163
Homo sapiens C-terminal
TTTCGCCGTGGACGCCGACCGTCCGGGACGAG binding protein 2 (CTBP2),
GGTTTCATCACCTTAAAT
83714355 82 581055 85651855 CTBP2 NM 001329 transcript variant 1 , mRNA
Homo sapiens minichromosome maintenance
FLJ44336, MAP80, FLJ45306, TGCTAGACATGGTGGACATTTGAGCAGCCTGAC complex component 3 KIAA0572, GANP CTGTGGGGAGGGGGTCT associated protein (MCM3AP) mRNA
51274347 59023096 63679346 MCM3AP NM 003906
Homo sapiens leucine rich
CACCTGGGAGAAAAGTG repeat containing 20 TCTGCTTGGAGAGTTTGCCCTTGTCTGTCTTGGA
FLJ10751. FLJ10844 AAGTGTGGGCAGCCAC
54723366 9951428 137 15594 LRRC20 mRNA ILMN 1683905
Homo sapiens FtsJ homolog 3 TCCCAGGAGAGCATGGGGACTAGGAGGAAGGG
FLJ20062, EPCS3 (E coh) (FTSJ3), mRNA TGTGGCATGGCTCAGTCT
46426277 74 59414 96 368454 FTSJ3 NM 017647
Homo sapiens PC4 and
GAACACCTGCCTTCTACC
MGC74712, PAIP, LEDGF, p75, SFRS1 interacting protein 1 TGAATATTAGGGTCATTTGGCACTTCTCAGCAAG CTCTGGTTGGGAGATGC PSIP2, p52, DFS70 (PSIP1 ), transcript variant 2, TAGGATACTTCTCATG AGCCACCACATCCCT
22807262 27468094 30498096 PSIP1 NM 033222 mRNA ILMN 1764228
GCACCGATGCACACACC
Homo sapiens glyoxalase I GTGCTCTTGGCTCTTGGGCTGGAGTACCGTGGT
GLYI, GLOD1 GCACCCCACCACTGTAC (GLO1), mRNA GAGGGAGTAAACACTAG
TCTGAAATTGGCGAGT
35506226 4031 106 42909644 GL01 ILMN 1691843
Homo sapiens 5-azacytιdιπe
ACAGAGGCTGGTGGTTGAGATGCCCACGGCTAA
AZ1, Cep131 induced 1 (AZM ), transcript GCACCTGTGGCTGCATT
119 15595 16728094 19892262 AZM NM 014984 variant 1 , mRNA
Homo sapiens glutamate-rich CTCAAACCCCCTTCACCC
RRB1, KIAA1942, WDR28, GGAGGTGTGGGTTCCTCCAACACAATTTGCTTCT WD repeat containing 1 AGGCCCCAGAACAGCTT GRWD GCCCGTTGTCTTCCTG (GRWD1), mRNA ACTCCACGGCATACA
723 85596 83620593 911 6268 GRWD1 NM 031485 ILMN 1781031
Homo sapiens tight junction
TTCTAGGAACTTGACGTG protein 2 (zona occludens 2) GCAAAACCTACCTTTGGGCGGTCTATACTGAAGC
MGC26306, X104, ZO-2, ZO2 ATGGGGCTTCCTGAGGA (TJP2), transcript variant 1, CCTCCACTCCCATCCC GCGGGTCCGGAGCGG
20042871 5471792 88 37347 TJP2 NM 004817 mRNA ILMN 1697510
Homo sapiens casein kinase TGGCTAAGCATGAGTTAA
ATAGCATTCCTTTCGAACACCACGGCAAGTAGCT
HCKID 1 , delta (CSNK1 D), transcript GCAGCAAAACGCTCCTC GCTCGTCTCCCATCGG variant 2, mRNA CATGTCTGGATGGGG
994 0476 1247 9727 14335977 CSNK1D NM 139062 ILMN 1714828
pOS + no GFs
Synonyms Probe Sequenco Probe_Sequence_l
Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens CSRP2 binding
CRP2BP, PRO1194, CCCTCAACAGTGATGAAGGAGACGTGTCTTGGA protein (CSRP2BP), transcript MGC15388, dJ717M23 1 TGGAGGAGCAGCTGTCC variant 1 , mRNA
345 S6427 447 9643 51808093 CSRP2BP NM 020536
ATCCTCAGGTTGTGGGG
MGC72007, RPS17L1, Homo sapiens πbosomal GCGAATTCAGAGAGGCCCAGTAAGAGGTATCTC
TATTTGTTTCTACTCCAG RPS17L2 protein S17 (RPS17), mRNA CATCAAGCTGCAGGAGG
CCTGGCAGGCAAGGC
31810 18 35732973 RPS17 NM 001021 ILMN 1727603
Homo sapiens solute carrier CCATGGGGGCTGGAGG
CTGTTTGGGGGTCTATCTCTCCATCCCTCTGTTG
ZNT3 family 30 (zinc transporter), GGGGCAGCTGGGACTCT
GTGCTGTGCCCTTGGC member 3 (SLC30A3), mRNA GGAATCTTCTTTATAAT
57 59533 7047686 SLC30A3 NM 003459 ILMN 1675222
Homo sapiens ELOVL family member 6, elongation of long GCAGGGCCACTCTTGGC
FAE, MGC5487, FLJ23378, CTGTCAGAGATGGCAAGGGCTTTTTCAGCATCTC chain fatty acids (FEN1/Elo2, AGAGACTTTGGGTTTGTA LCE GTTTATGTGTGGAATT
SUR4/Elo3-lιke, yeast) GGGGTCCTCAAGTGC
(EL0VL6), mRNA
37951428 978 15594 7837476 EL0VL6 NM 024090 ILMN 1749213
Homo sapiens DPH3, KTM 1
MGC20197, DPH3A, DELGIP1, GCTCGCATGGCAGCCGC homolog (S cerevisiae) TTCCGGCGAAGTTAAACCCTCGGAGCTGGCCTC ZCSL2, DELGIP, KTM 1, TTCGGCGCCCGGCCCCG
(DPH3), transcript variant 2, GGACTGCTGGGGCGTTA DESR1 CGGCCAGCTAGGGGCG
79481705 24298929 18952261 DPH3 NM 001047434 mRNA ILMN 1662010
Homo sapiens
FLJ12443, PFAAP3, Ipcat, lysophosphatidylchohne TGCTGGGGTGTGAGGGCAGAGGGAGGGTTGCC LPCAT1, AYTL2 acyltransferase 1 (LPCAT1), ATGAAGGAACTTGGGATT
8748932 19338095 16058095 LPCAT1 NM_024830 mRNA CIP3, Rrp43p, EAP2, Homo sapiens exosome
GGCAAACTCTGTTGTCTTCACAAACCAGGTGGAA DA421P11 3, RRP43, OIP2, component 8 (EXOSC8), GTGGGCTAACTGGAGC
70070593 13532393 11584642 EXOSC8 RP11-421P11 3, p9 NMJ81503 mRNA
FLJ21474, MGC119474, CTCCCAGCCATCTCCTCT
Homo sapiens SATB GCAGTGGTTCTAAGTGAATCTGTGGGCATTTTAG FLJ32076, MGC119477, _ „ „„„„ ™,. TCCCTAAGGCCTCTGTCT KIAA1034 homeobox 2 (SATB2), mRNA CCATAGCTCTGGTT CCTGTGGTCTTGCCAG
11673512 7590059 494 1601 SATB2 NM 015265 ILMN 1804993
Homo sapiens membrane-
MARCH-IV, RNF174, CCTGCCAGGGAAGGCCACTGGGTGTTCACCTGC associated ring finger MGC104908 AAAGTTTCTGGTTGTCA (C3HC4) 4 (MARCH4), mRNA
10289644 1799281 15727935 Mar-04 NM 020814
Homo sapiens metal response CGTGGGATCTGCACACG
ΛJ976O132, PCL2, M96, RP5- GCACTCTGATTTTCTGTAGGTACAGTTCAAAGCC element binding transcription TCTTTGTCAGTTGTGGTC 976013 1 CTAAAGGGAGTCTGGC factor 2 (MTF2), mRNA ATG ATCTTAGTC AC C
11242262 254 42679 20956012 MTF2 NM 007358 ILMN 1664016
Homo sapiens FAST kinase CTGGGCACAGAGCCAAT
CGAAATAGTTGGATCAAGGCTGCCACCAGGGGC
KIAA1800, FLJ21901 domains 1 (FASTKD1), GTTCGTCATTGCAGCTCT TGAAAGGATTGCTTTGG 34643 mRNA CAGCAAACTGGGTCA
85481 13 11947261 FASTKD1 NM 024622 ILMN 1738237
Hom noo ssaappiieennss aappooppttoossiiss-- indu icciinngg ffaaccttror rπi —toc 'hondrion- GCTGCTCCCGGAAATGC aassssoocciiaatteedd,, 11 (AIFMI)1 nuclear GGCTAGCTCTGGTGCATCAGGGGGCAAAATCGA
MGC111425, PDCD8, AIF gene encoding mitochondrial TAATTCTGTGTTAGTCC
CTGGGTGGGAATTGG protein, transcript variant 1 ,
8453935 110501785 103493454 AIFM1 NM 004208 ILMN 1769158
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Descπption Probe Id
Homo sapiens zinc finger CTAGTCTCCATGGCCAAGCACTCAAGGATTGATG
Zfp105, HF 10 HF10 protein 35 (ZNF35), mRNA GACACCACACACCAGC
154 9226 21933928 20285596 2NF35 NM_003420
Homo sapiens
FKSG32, FLJ23638, CCATAGACAATTTGCCAGGATCTAGGAACCACCT pseudouridylate synthase 3 2610020J05Rιk AATGGTAGGTGGACAG
16288928 251 75179 22722678 PUS3 NM_031307 (PUS3), mRNA
Homo sapiens zinc finger CGGGATTGAGGAAGGTC
ZNF634, MGC61687, ACAAGTCAACACTACACGAATCCAACATCAAATC protein 280D (ZNF280D), CGCACAGCCTGTCTCTG MGC21637, SUHW4 CAGTGCCTGCCTCACC transcript variant 2, mRNA CTCAGTTGCAATAAAC
14703928 180 1518 17095595 ZNF280D NM_001002843 ILMN 1756920
Homo sapiens v-akt murine
PRKBG, PKBG, thymoma viral oncogene GGGGATTGGTTCCAGAC DKFZP434N0250, RAC- GGGCTCTTGATAAAGGATCCAAATAAACGCCTTG homolog 3 (protein kinase B1 CCCCTAAGCATACCTAAA gamma, RAC-PK-gamma, STK- GTGGAGGACCAGATGA gamma) (AKT3), transcript TCCACAGATGCTGTG 2
41 826195 17065178 12064762 AKT3 NM_181690 variant 2, mRNA ILMN 1663754
Homo sapiens slingshot CCACTTGGAGAGCAAGA
GTCCAGAAGACTCTCCTCTGACTGTTACCTTTGC
KIAA1725, MGC78588, SSH-2 homolog 2 (Drosophila) GGGCTTGTGGACTTGGG CCCAAGCCACCCCAAA (SSH2), mRNA GGAGCGGTTGTGAGAA
97897705 18871011 161 43512 SSH2 NM_033389 ILMN 1794156
Homo sapiens neural
TUBGCP7, FLJ35902, GCP- precursor cell expressed, GGATGACTTTAGAGAAGCATGCCATAGGGACATT WD developmental^ down- GTGAATTTGCAAGTGG regulated 1 (NEDD1), mRNA
15098658 61 392067 43381256 NEDD1 NM_152905
Homo sapiens dyskeratosis GGGGAGGAAGACACCTC
NAP57, NOLA4, XAP101, GTACAGTGCTCACCTAAATCCATCTGACTACTTG congenita 1, dyskeππ (DKC1), ATATCAGCCCTCAAAGG dyskeπn, DKC TTCCTGTGCCCTCTTG mRNA CTCCCCTCACTGTCTC
14154559 2785056 23462144 DKC1 NM_001363 ILMN 1686587
MGC87345, KIAA0844, Homo sapiens zinc finger
CTTTGTCCACATGGGCCGTTGACCTTAGAGTTAA MGC41821, UAN, ZNF365D, protein 365 (ZNF365), GGCGGTTGC I 1 1 I I I G
18093095 4130268 33043512 ZNF365 Su48 NM_014951 transcript variant A, mRNA Homo sapiens CP110 protein CACATTC I I I I I I GGTGTTCATAGCTTCTTCTCAT
KIAA0419, DKFZp781G1416
3170893 711 34766 58539764 CP110 NM_014711 (CP110), mRNA ACAGGTGCCAGACAC
ATGGGCTGAGCTGCACC
Homo sapiens zinc finger AGATGTGGCAAATGCCTGACCACCTACTGTAATG
FLJ10997, FLJ21142 AGACCCTCACACACCAC protein 654 (ZNF654), mRNA CAGAAGCACTTGAGGC AGCACTGCAAGCTGAT
47 102837 140 5476 11347699 ZNF654 NM 018293 ILMN 1759889
Homo sapiens COX17 cytochrome c oxidase assembly homolog (S GAGGCTGGCATAGATTTGGCTGTCTCCGCTCAT
MGC117386, MGC104397 cerevisiae) (COX17), nuclear AGCTGCTTTTGGCGCGA gene encoding mitochondrial protein, mRNA
23630725 3810781 3395 3228 COX17 NM_005694
Homo sapiens vimentin (VIM), CCAAACTTTTCCTCCCTGAACCTGAGGGAAACTA
FLJ36605
28440006 39688508 36654 75 VIM NM 003380 mRNA ATCTGGATTCACTCCC
Homo sapiens transmembrane GGGCCTCTCCTCAAGGA
GCCAAGTCAACAGTGTCTCTGGGGTGGCATCCT
FLJ37611 protein 170 (TMEM170), GAGATGGAGGGATACAA TTGCACTGAAATTTACA mRNA TTCTTGGTTCAGTGGG
11603512 19774344 17448929 TMEM170 NM 145254 ILMN 1678862
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens signal
TGACACCCCTGCCCATTTTCTGTCTTTAATTAAC
ALURBP, MGC110981 recognition particle 9kDa CAAGGTGTTAGGTGTG
5486298 76231396 70286978 SRP9 NM_003133 (SRP9), mRNA
Homo sapiens ventricular
MGC126709, FLJ12604, zone expressed PH domain AGTACAGAGTGTGAAGGCTGTGGCCAAGAAACG KIAA1692, MGC142115, homolog 1 (zebrafish) CAGGGACCGCTCTCTCC MGC111426
14524389 10862262 NM 024621 (VEPH1), mRNA
Homo sapiens mesoderm
GGTTGTGTTATCACTCCCACCCCCTACCCCAGC
MGC99595 development candidate 1 ccGTCTTCCGGAATTTc
2504816 12697262 85306 MESDC1 NM 022566 (MESDC1), mRNA
Homo sapiens G elongation hEFG1, FLJ12662, EFG1, EFG, factor, mitochondrial 1 GATGCCGGGGACTCGGA
GTTTCCAGAAAAAGTTGGGCTTTCCCAAGCAGTT EGF1, FLJ13632, GFM, (GFM1), nuclear gene CCCCGCACCCTGAGAGT
CTATTACCCGGTTCAG FLJ20773, EFGM, COXPD1 encoding mitochondrial CTTTGTTAATGGATGT
44183926 6380893 5782643 GFM1 NM 024996 protein, mRNA ILMN 1686854
Homo sapiens Sp4 AATGCACCTCATTCTTCC
MGC130009, SPR-1. HF1B, ATGCATGTCACTAAGTTGTCATCCCACATAAATT transcription factor (SP4), CTGGCCTCTTTCCCACC MGC130008 GATGTGCAGCATAGGG mRNA CACAGCCCCCAGAGG
4057228 13748096 10475186 SP4 NM_003112 ILMN 1732323
Homo sapiens KIAA1712 GTCAGTTGCTTGTGCTGCCCTGTCTATGTTATGC
PS1TP3
17984763 28662262 26080597 KIAA1712 NM 001040157 (KIAA1712), mRNA TCTGAATAGGTCTCGG
Homo sapiens mitochondrial ribosomal protein L48
GGAGTCAGACTGTCAGTGAAGGAGCACACTGAA
CGI-118, MGC13323 (MRPL48), nuclear gene GAAGACTTCAAGGGACG encoding mitochondrial protein, mRNA
28430594 48592676 42969345 MRPL48 NM_016055
CAAGTCTCAAGAGACACT
Homo sapiens centromere
FLJ10545, C6orf139, CENP-Q TAATTCAGATGACTTGGA GCCAATGGCTTACAGTTTCTGTCTGGTCATCTGG protein Q (CENPQ), mRNA AACTTGAAAAATCCTC TGCCACTGACAAAC
5759127 28593094 19349762 CENPQ NM_018132 ILMN 1720955
Homo sapiens thymosin beta AAGAACACCCTGCCGACCAAAGAGACCATTGAG
MIG12, TB10 33132957 43157133 40647273 TMSB10 NM_021103 10 (TMSBIO), mRNA CAGGAGAAGCGGAGTGA Homo sapiens cysteine
CCCATTCGTCTGTCCCA conjugate-beta lyase, CCTTCCCTGGCTCATCTTGGCCTTGGGGAGTTG
GTK, MGC29624, KATI GAGCTTATTGGCCACTG cytoplasmic (CCBL1 ), CCTTTAGGCTTGAGTCC GGTCTCACTCCTGAGT
3641363 7964813 6665614 CCBL1 NM_004059 transcript variant 1, mRNA ILMN 1697559
Homo sapiens zinc finger, MIZ TGCTTTGTGGCCCAGAA
MIZ, ZimpiO, FLJ13541, CGTACACACATAAACACACCCACCAGTGCAGCCT type containing 1 (ZMIZ1 ), TATGGGCTATCTTGGTAT hZIMPIO, KIAA1224, RAI17 GAAGTAACTCCCACAG mRNA GAGTTACATGTTCAC
12902476 18534976 1714781 ZMIZ1 NM_020338 ILMN 1738124
Homo sapiens endothelial cell- TTGGGGGTCAGGCAGCC
CTGCTGATGTAGTTCCCGGGTTACCTGTATCTGA eπdocan specific molecule 1 (ESM1 ), AGTGAGATGAGGGATGG AGGACGGTTCTGGGGC mRNA GCCTGGCATTCTTGTA
16033009 21070393 70432263 ESM1 NM_007036 ILMN_1815522
TCAGAAGCACATAGCTAT
PRAD1. D11S287E, BCL1, Homo sapiens cyclin D1 CGGCGCTTCCCAGCACCAACATGTAACCGGCAT TGCCATTCATCCTCCGCA U21B31 (CCND1), mRNA GTTTCCAGCAGAAGACA GCCGGCTGGGCAGT
8600764 1994209 16475582 CCND1 NM_053056 ILMN 1678974
RP13-122B233,
Homo sapiens cofactor of TGACGCGGATGGTGGGGAAGAACGTGAAGCTGT DKFZP586B0519, NELF-B, BRCA1 (COBRA1), mRNA ACGACATGGTGCTGCAG
11588095 18166846 16444762 COBRA1 NELFB NM 015456
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description
Homo sapiens glycine GCCTCCCCCTGCGAAACCTGTTATTCCAACAGCA receptor, beta (GLRB), mRNA GCAAAGCGAATTGATC
12095178 161 75177 15066846 GLRB NM 000824
Homo sapiens RecQ protein- like (DNA helicase Q1 -like) ATCAAGGGATGTCCAATCTTTTGGCTTCCCTGAG
RecQ1, RECQL1 (RECQL), transcript variant 1 , CCAGCGAATTGTGCAC
67597266 56945593 RECQL NM 002907 mRNA
Homo sapiens guanine
FKSG1. GY2, DGCRK3, nucleotide binding protein (G TTTCCTTTTGTGGAGTGCCTCATCACAGGACGGT WDR14, KIAA1645, WDVCF protein), beta polypeptide 1- GACTCTGGGGGCCAGC lιke (GNB1 L)1 mRNA
97 55867 191 01428 16651845 GNB1L NM 053004
PREDICTED Homo sapiens solute carrier family 35, ATGGTGCATTCTGTAACCATGGAGTCTTCTGTTT member F3 (SLC35F3), ccTGGGGGAAAGGGGC
1028856 267 38928 14040182 SLC35F3 XM 001132419 mRNA
Homo sapiens STARD3 N- GATGCACAGAGGACACA
GAGTCTCCCTGTCGACAGTAAAGTTGAAATGGT
MGC3251, MENTHO terminal like (STARD3NL), GAAGGACTTGGCAGCAG
GACGTCCACTGCTGGCT mRNA GGTGATGACCTGATCA
34485596 471 82263 441 62262 STARD3NL NM 032016 ILMN 1684943
Homo sapiens casein kinase GCCTCGCCCCAACACTG
GGACTCCCAGCAGGCAAATCCCCACCATTTGAG 1, gamma 3 (CSNK1G3), TCCTTCCCTGCCACTTCA AGCTCACCTTGCAGCAG transcript variant 1 , mRNA ACCCCCAGCTAATAA
1544992 85425766 5537774 CSNK1G3 NM 004384 ILMN 1763749
TGCCACCAGACCAACAC
Homo sapiens apoptosis GACCAGCTAATCTGGACCTCAGAGATAGATCAG
AAC-11, AAC11, API5L1 ccccAGACTTCcccACC inhibitor 5 (API5), mRNA CCAGTGGCCCAAAGCCA TTCAGCCACCATCAGA
99398096 1341 0894 12576477 API5 NM 006595 ILMN 1784477
Homo sapiens PR domain TGCTCAAGGCACAACCTCTGGGCTGGAGTAGAG
MGC45046, PFM1 containing 4 (PRDM4), mRNA GACTCTGGTGGGAAGGT
173 95178 231 68927 217 56427 PRDM4 NM 012406
Homo sapiens Morf4 family associated protein 1-lιke 1 TCAGGGCCTGGAAAGTCTCTTCCAGTTCATCAG
PP784, MGC9651 (MRFAP1L1), transcript GGTAGTAGACCTGTCAG
99080176 11769976 1134 9226 MRFAP1L1 NM 203462 variant 2, mRNA Homo sapiens dachshund
CAGTGACCACACAGCTC homolog 1 (Drosophila) GGTAGCCTAGTTATTTGAGCCTGGTTTCAATGTG
DACH, FLJ10138 CTCCATGCCTGACCAAC (DACH1), transcript variant 2, AGAACCACGTTTACTG AGGCCCAGCTTTCCCT
58615985 8602163 47 72538 DACH1 NM 080760 mRNA ILMN 1694950
DKFZp686N15250,
TGCCCCAAGCTCCAGCG DKFZp686O03173, Homo sapiens ring finger GGTTTGAAAGAGCTCATCGCCAAGTTCTTGATCC
.,..„ ,„■.„-.,>„, „-,» GTATTCTATCAGCCCATC DKFZp686A01276, FLJ13449, protein 219 (RNF219), mRNA CTCCTGGAAAGCCTG ACTTGCATTCCAGGGG
11647678 302 63095 248 1101 RNF219 FLJ25774 NM 024546 ILMN 1796950
Homo sapiens zinc finger,
DKFZP586K0524, ZNF375, CAGCCCACCTCACTATGGTGCTGGGTAGAGGGG DHHC-type containing 5 KIAA1748 ATACCTGGGTTCTAACC
23872263 278 53094 2703643 ZDHHC5 NM 015457 (ZDHHC5), mRNA
Homo sapiens scavenger
GATGCTAGCGACACATCGCTGTTGGGAGTTCTT
CD163B receptor cysteine-πch type 1 CCTGCCTCTGAAGCCAC protein M160 (M160), mRNA
32233047 90307846 74 51542 M160 NM 174941
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens lymphocyte- CCCATTTCAGACAGCAAC
TCCTGCAAGGATATTGTGGCTGGAGACATGAGC
WP34, pp52 specific protein 1 (LSP1), ATGTAGAAGATGTTCAGC AAGAAAAGCCTCTGGGA transcript variant 4, mRNA GTGCAGGGCTTGCT
1S340S94 1904851 182 12262 LSP1 NM 001013255 ILMN 1773388
Homo sapiens solute carrier family 25 (mitochondrial thiamine pyrophosphate
ACACTCCTGGTCTGGATGGGGCTGCTGCTTGAG
TPC, MCPHA, DNC, MUP1 carrier), member 19 TGCAGAGGGCTGCGGTA (SLC25A19), nuclear gene encoding mitochondrial
2996322 8290193 6949157 SLC25A19 NMJ321734 protein, mRNA
Homo sapiens radical S- vιg1, cιg33, 2510004L01Rιk, CGCTGGAACCTTGGGCAAGGAAGAATGTGAGCA adenosyl methionine domain cιg5 AGAGTAGAGAGAGTGCC containing 2 (RSAD2), mRNA
6 5091376 66356186 49 971592 RSAD2 NM_080657
Homo sapiens haloacid rrr r rrn rrτrrτ dehalogenase- HKe hydrolase ∞™ GCTCAGCCCTTCCTAGGGGCCTCTGCCCTTTGA
DXF68S1E. GS1, FAM16AX TGTCCTTGAGCTACTCT
?HOHO1Ar:Z1A TCCAGGTCAGCATCT
1435893 39608093 317 9268 HDHD1A NM_012080 ILMN 1670453
MGC126692, MGC126696, H- Homo sapiens semaphorin 7A, SEMA-K1, JMH, H-Sema-L, GPI membrane anchor (John CCTGGGTCCCACAGGACAGCCGCCTTGCATGTT CD108, CDw108, SEMAK1, H- Milton Hagen blood group) TATTGAAGGATGTTTGC
14668591 17589345 107243546 SEMA7A Sema KI, SEMAL NM_003612 (SEMA7A), mRNA
Homo sapiens karyopheπn
IPOA4, SRP4, hSRP1, cccTTAAAAGTCCAAATCTTCTTGATATTGTGAAC alpha 3 (importin alpha 4) SRPIgamma CGTACCCCTTCCAGT
9100643 1386 106 12692059 KPNA3 NM_002267 (KPNA3), mRNA
Homo sapiens tubulin, alpha GGTCCCCAAAGACGTCAATGCGGCCATCGCCAC
46393356 91 756096 793021 TUBA3E NM_207312 3e (TUBA3E), mRNA CATCAAGACCAAGCGCA
Homo sapiens eukaryotic AGCTGGAGAGCTACAAC
MGC45041, HSU93850, eEF- GGCTTTGCAGGCCATATAGCCTCTGCTGCAAAT elongation factor-2 kinase CTCAGGGCACAGTGGGA 2K GCTCAGCCCTGCTGTTG (EEF2K), mRNA AAGGATGAGCAGGCCC
24666011 372 00177 34220593 EEF2K NMJ313302 ILMN 1670975
Homo sapiens polymerase
CCTTTGTCAGACCATAAG (RNA) III (DNA directed) GCCATGTGAAAGGGAGAAGACAAACATCCACGA
MGC13517, RPC6, RPC39 AGTTTCTCCAAAAGTGGT polypeptide F, 39 kDa ACCAGGAAGTGGGTCCT CAGTTTGGCTGGGC
9369795 231 24762 19203928 P0LR3F NM_006466 (POLR3F), mRNA ILMN 1807554 Homo sapiens RNA binding motif, single stranded CAGAAAGGTGTGGTGCTGGAACATCGATGAAGG
SCR3 interacting protein 2 (RBMS2), AGCCCTACTTACTGAGC
3370893 48728094 451 56845 RBMS2 NM_002898 mRNA
Homo sapiens chromosome 2 TTCACCGTCTCACATTAG
GGGAAAAGCCAAGCTCCAGACAAGGAGTGCTGT
FLJ21820 open reading frame 43 ACAGGCCAATGCATCCC TAGCCCAAGGGGAAGAG (C2orf43), mRNA TTAGGAGCTGCCCCA
10942679 1500893 141 96011 C2ORF43 NM_021925 ILMN 1654632
Homo sapiens CHK1
GATCGGACCATCGGCTCTGGGGAATCCTGGTGA
CHK1 checkpoint homolog (S ATATAGTGCTGCTATGT
30697263 786 57263 6522101 CHEK1 NM_001274 pombe) (CHEK1), mRNA Homo sapiens protein geranylgeranyltransferase GTAGGGGGATTTGCCAAGTGGCCAGACAGTCAT
BGGI, GGTI type I, beta subunit CCAGATGCTTTGCATGC
54 894432 131 88928 1122518 PGGT1B NM 005023 (PGGT1B), mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sβqueπce_l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens RAP2A,
TATCAGCAGTCTTGTGTTAGCACTGGGTAAGCTT
KREV, RAP2, RbBP-30, K-REV member of RAS oncogene TAATTGTCCCTTAGCC
471 8643 617 56433 5899226 RAP2A NM 021033 family (RAP2A), mRNA
Homo sapiens CDK5
HSPC167. CDK5RAP1 3, regulatory subunit associated GGACCACTCTGAGGGACTCTTCTGCATATTGCT C20orf34, CGI-05, protein 1 (CDK5RAP1), GACCTGAGAGGATGGcc CDK5RAP1 4, C42 transcript variant 1 , mRNA
347 93094 412 13513 40328094 CDK5RAP1 NM 016408
Homo sapiens oxysterol
CTGTGAACTTCATGGCA binding protein-like 6 CCACACGATTGTTCCACTGTCTGGAAGCACCATC
ORP6, MGC59642, FLJ36583 . . GAAACATACCTGCTGTTA (OSBPL6), transcript vaπant 1, CCCTATCGCAGGACTC
97 09683 317 51843 25049344 0SBPL6 mRNA ILMN 1668795
Homo sapiens transmembrane GGGCTCACACAAAACAT
GGACAGAAGGACCTCCCAGCCCCCAAAGGATCT
HSPC196 protein 138 (TMEM138) AACGAAGAGACTGGAGA cccAGTGACCAAAGGAT mRNA. CAATGTGGGCCCTCTG
2895893 4342976 401 78094 TMEM138 ILMN 1761781
Homo sapiens cerebral
MGC74868, MGC4067, cavernous malformation 2 AGAGCCAGTCCTGTCGGCTGGGCCCTTGGACG MGC4607, C7orf22, PP10187 (CCM2), transcript variant 1, GCTGTCAGTTTTGCACAT
10530892 1227 2976 1196606 CCM2 NM 001029835 mRNA
Homo sapiens motile sperm
GTACCCACCCGGTATTCCTAAAATCCTAAAAAGA
MGC26706 domain containing 2 TACACCTTGCAGTAGC
44263145 59016945 55715096 MOSPD2 NM 152581 (MOSPD2), mRNA
Homo sap.ens Crate synthase GGCTGTTCAGCAGAGAA
(CS), nuclear gene encoding CCTCAGGCAGAGGATGTTCTGGACCTCCCCCTC
ACCCATGTCCTCTCTCCA mitochondrial protein, TTGGTCCCTACTAGAGA TAGGGCCTGTTTTAC transcript variant 1 , mRNA
4680476 6203809 5894976 CS NM 004077 ILMN 1683562
Homo sapiens phosphatidylinositol glycan GCTGAAAGACTGGCATCCTCCTGGGGGCTTTAT
MGC22559, GPI8 anchor biosynthesis, class K TCTGGGATTATGGGCAC
33963928 504 99762 46748096 PIGK NM 005482 (PIGK), mRNA
Homo sapiens t-complex 1
TCP-1-alpha, CCT1, D6S230E, GCCCAAGGCTATAGCCCCTCCTTCAATATTGACC
(TCP1 ), transcript variant 1 , CCTa, CCT-alpha TAACGGGGGAGAAAAG
5974224 11922433 91 96892 TCP1 NM 030752 mRNA
Homo sapiens chromosome 5 CGGAGCACGGAAGCACA
AGGAAACACAACTGGTTACCTATGAGACCTGTTC
FLJ25291 open reading frame 30 CACAAGCTCTTTATGAAT TGTCCGTGTGCCTACG
(C5orf30), mRNA TCTGCTCTCCATCAG
213 33095 573 9851 48001013 C5ORF30 NM 033211 ILMN 1810593
Homo sapiens RNA binding
MGC3331, MSSP-1, MSSP, motif, single stranded TAGTCCGACTTCACCCATGGTGTTCTGTGCTTGC YC1, SCR2, MSSP-3, interacting protein 1 (RBMS1), AGTGCGAGTGTTGCTG MGC15146, MSSP-2 transcript variant 3, mRNA
761 8726 1867 8477 15824226 RBMS1 NM 002897
Homo sapiens La
MGC104360, DKFZP564K112, πboπucleoprotein domain GCACAGAGCCTCTACCTGGCAGGAAACAAGTCC HDCMA18P family, member 7 (LARP7), GGGATACTTTGGCAGCA
555 83093 69568933 657 5268 LARP7 NM 015454 transcript variant 2, mRNA Homo sapiens asparagtne- linked glycosylation 13 AGGACTTACTATTGi I I I I IAAGGATCTCCTCTCA
YGL047W, GLT28D1, MDS031 homolog (S cerevistae) CAGTGGTAATGAAAC
45755493 104 51428 8625282 ALG13 NM 018466 (ALG13), mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens coiled-coil CCAGCCCTCGACTCTTA
GCTTGACTCTAACCTGGAGAGCTTCTTAAGTGAT
FLJ20364 domain containing 99 GTAAATTTGAGAGTTTAT GCCCCTTCATGGAGCT (CCDC99), mRNA ATGGAACACAAACCC
2704893 98407263 693 7643 CCDC99 NM 017785 ILMN 1769099
Homo sapiens chromosome GTCCTCAGTTCCCGTCC
MRG15BP, MRGBP, FLJ10914. GGCCGCCCCAGTGCTGATGGAGATGCCACTTTC 20 open reading frame 20 ACCCTTCAACCAGTGGC Eaf7 GTGTGACTGCGAACATT (C20orf20), mRNA TCCTGGGAGACTTTTC
95228094 1644 1393 1439 1519 C20ORF20 NM 018270 ILMN 1679646
Homo sapiens PAP associated mtPAP, RP11-305E63, CTCATTGGCCCCCTTAACCTGGTCTGAAGTTCTG domain containing 1 (PAPD1), FLJ10486 GGATGTTTTCAGTTTG mRNA
254 10596 28893097 279 15594 PAPD1 NM 018109
Homo sapiens KDEL (Lys-Asp-
CAGCAGCCTTAATCTACATAATTCTTCATCTCGC
MGC33424 Glu-Leu) containing 2 CAATTCAGCCGCAGCC
965 58093 11336643 10903351 KDELC2 NM 153705 (KDELC2), mRNA
Homo sapiens transforming
GCTTATGCAAGTGACGG growth factor beta regulator 4 CTACCTCAAGGACAAGATGCGCAAAGCGGTGGC
FASTKD4, CPR2, KIAA0948 TGCTGCTCTTGTTCCACC
(TBRG4), transcript variant 3, TGAGGAGCTGGCCAAGT CCCACCCAGATGGTC
TBRG4 NM 199122 mRNA ILMN 1683316
Homo sapiens transmembrane
MGC23909, DKFZp686l1152, TGCCAGAATGTAGTTGCCATCAGATTTGATTGTG protein 167 (TMEM167), FLJ30508 AACAAGGACTGACTGC
454 5226 74058093 65348096 TMEM167 NM 174909 mRNA
Homo sapiens zinc finger GCAGGGGTGTCTCGGTT
GGCCAGCGGTGCCTTTACGGACTGATCGTGTGG
MGC45293 protein 200 (ZNF200), TGCATTTCTGTTGGAATG TGCGATTTAGGGATTCT transcript variant 3, mRNA ATCCGAACTGGACTC
45 112694 10609761 8570657 ZNF200 ILMN 1736619
Homo sapiens vitamin K epoxide reductase complex, TGTAGCCCTAGCCCCCTGCCCTCAATTGTAAAGT
DKFZp762H0113 subunit 1-hke 1 (VKORC1L1), GAGCAACCATTGCTAG
497 13513 8680393 74863513 VKORC1L1 NM 173517 mRNA
Homo sapiens Rho GTPase
FLJ00267, RP11-544M226, activating protein 30 CAGCTCCCCACCCTCTGCCTCCAGTCACCATGT FLJ44128 (ARHGAP30), transcript GCAAGAGAGGTCCTGTA
154 14345 21806845 19994762 ARHGAP30 NM 001025598 variant 1 , mRNA
Homo sapiens heparan sulfate
FLJ11317, MGC131986, ACTTGCAGTGGCTGAACAAAGAGCATGGCTTGA 2-0-sulfotransferase 1 dJ604K52, KIAA0448 GAATCAAAGGGATCTGC (HS2ST1), mRNA
4046819 8369798 71 10375 HS2ST1 NM 012262
DKFZp686K23100, Homo sapiens matnn 3 GCAACTTACACTGAGGG
GGCCATAATCCTAGATGCACGCTTCTAATTCATG DKFZp686K0542, KIAA0723, (MATR3), transcript variant 1, CATGTATCCTAGCATCTG TACCTGCACATGTGAC MGC9105 mRNA TGTGGAAGCCACAGA
3017 3975 4302481 3910281 MATR3 NM 199189 ILMN 1792383
Homo sapiens zinc finger ACTGCAACCTCATTCGCCATCAGAAGATCCACAC
ZSCAN9, PRD51 protein 193 (ZNF193) mRNA AGTGGCTGAGCTGGTC
121 44762 154 91428 14469762 ZNF193 NM 006299
CATGGAGCTCAAGATGT
MGC14317, MGC1022, Homo sapiens ring finger CAACTCGTGAGCCCACGTCGGCCGTCGGGAAAG
CTTGTGTCTGTGTGGCT FLJ20552 protein 126 (RNF126), mRNA CACGGGGCCTTTCCCAC AGATGGCCTCTGCTTG
18598929 298 1601 262 03094 RNF126 NM 194460 ILMN 1739876
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
TGTGGTGGTGCCATGCA
Homo sapiens tetraspanin 6 CTGCTGGAATGGTTGTTGTTTTCCACTGAGAAAG
T245, TSPAN-6, TM4SF6 ATCCCCTTTTGGTAGAAT (TSPAN6), mRNA CTAAGCCCTACATTTC TGCCACAAACAAGGC
71 19125 125 86012 10667262 TSPAN6 NM 003270 ILMN 1793549
Homo sapiens hydroxy-delta-5
GTGACTTCACTTTTCTAA steroid dehydrogenase, 3 beta TCCTCTGTCCTCTCATCCCAGTCCTGATGGCCG
PFIC4 GACCCCTCAGCGTTCAG and steroid delta-isomerase 7 CTTGGTGAGTGTCTGGT CAGCCCACAGCTCTG (HSD3B7), mRNA
69435295 84 74206 79401505 HSD3B7 NM 025193 ILMN 1767649
Homo sapiens RNA binding AAGATGCTGAGTGTCTG
CCTGATAGTCTGTGTACAGCATTGTTTTGTCTGG
MGC42237, FLJ44612, DRB1 motif protein 45 (RBM45), CACTGCTCCACTTGTCC GAAGCAGGGATTGCTG mRNA CCCCGCTCTCTCCTCA
24073096 34293927 311 48096 RBM45 NM 152945 ILMN 1697800
Homo sapiens ubiquitin- GATGTATGGTATCTCCCT conjugatmg enzyme E2G 1
UBE2G, UBC7, E217K TTGCCAAGCCATCCTGG TTGATATGCCCACTCACCCTCGACGAATCTGCCC (UBC7 homolog, yeast) GCTTTGGGCTGTGGTG
ATGAAACCAAAGGAG
35000595 44598096 4174726 UBE2G1 NM 003342 (UBE2G1), mRNA ILMN 1681783
Homo sapiens F-box protein TCCCCCCAGTCATATCTC
FLJ12673, PRMT9, UG063H01, CAATACTTTTCCTTTTGTAGCCACTTTGAGTCTG 11 (FBXO11), transcript ATGATTTCCACAGTTGTT MGC44383, FBX11. VIT1 CAGTTGTCAGTAAGCC variant 2, mRNA GTATTGGTGTGGAG
41 58118 9391014 7644257 FBXO11 NM 018693 ILMN 1808636
Homo sapiens DPH2 homotog
CAAGTGTTCAGACAGCCACATGAGGGGACAGTG
DPH2L2 (S cerevisiae) (DPH2), CAGCTACAGGATATGCC transcript variant 1 , mRNA
64768933 881 8893 81001843 DPH2 NM 001384
CAGCTGGGCAGATTTGG
Homo sapiens pleckstrin 2 CATTCAGGCCAGCAGCAAGGCTGAGCGAGCCGA CCTGCAGGGTATAGTTG (PLEK2), mRNA GTGGATTGAAGCTATCA GCTGACCTCAATCTAG
37 06746 14082059 4897976 PLEK2 NM 016445 ILMN_1726930
Homo sapiens SET and AAAAAATCAGCAAAGAAG
GCCTGCTTACCTCCAGAGACACACCGTTCCACTT
KIAA1936, ZMYND21 MYND domain containing 4 AAAAGACTCCTGGCTGT ACAGTATCTAGCTTCC (SMYD4), mRNA GTGAAAATTAAAAAA
117 32262 18555594 16264761 SMYD4 NM 052928 ILMN 1652104
Homo sapiens WW and C2 CTAATAAAGTGGGCGCG
KIBRA, FLJ23369, FLJ10865, CTTCTTGAGCTGTGACGTG I I I I domain containing 1 (WWC1 ), AGAGGAGGCTGCTGTGT KIAA0869 CCAACGTGGAGCGGGC mRNA GTTTCCTGCcccAGCc
38 335567 22362262 13540594 WWC1 NM 015238 ILMN 1685037
Homo sapiens GGCCTTTCGTCATGCCA
MGC117235, FLJ23017. CTTTTGCAGTCAATCCCCTGCTCCTATCCTTGGC methyltransferase like 4 CAAGCCTCATATATCATG HST661 CCCTGGCAAACACTGG (METTL4), mRNA ACCGAACTCATGCTG
86901825 151 98929 129 13095 METTL4 NM 022840 ILMN 1780146
MYM, RP11-181E224, Homo sapiens zinc finger, GCCATCTATAAGGATTGTGCCAGTTTACAGTCCC FLJ23151. FLJ43753 MYM-type 1 (ZMYM1), mRNA ACCCACAATGCATGAG
134 15178 2700851 21989761 ZMYM1 NM 024772
FLJ20283, MSTP141, Homo sapiens dipeptidyl- GGACACCGACTTGGGAG
TGGGTCACCCTGACCAGAATGAACAGGGCTATT MGC26191, FLJ14920, DPRP1, peptidase 8 (DPP8), transcript GACAGGTCCTGAATGTC ACTTAGGATCTGTGGCC DP8 variant 1 , mRNA CTTTCTC CAGTGTAAC
221 30594 3380351 301 9268 DPP8 NM 130434 ILMN 1759252
pOS + no GFs
Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Synonyms
Genbank Description Probe Id
Homo sapiens chromosome ACTCCAGCCCGCAGCAC
TRM61, FLJ40452, GCD14, TCTGACAGCCTCAAGGAAGGAGCAGTGCCTGTG 14 open reading frame 172 ATTTCCGCTGTCCGTCA Gcd14p TCAGCCATGGGGCCCTT (C14orf172), mRNA GTAATTGTGTCCTCTC
11835178 18868929 16488512 C14ORF172 NM 152307 ILMN 1722056
Homo sapiens nudix
GATATGGTGCCCTGTGT (nucleoside diphosphate GCCGAAAACGCAAGGCCGAAGCCAAAGCCAGG hYSAHI, YSA1H ATCCCAGAGATGCTAGA linked moiety X)-type motif 5 GGATGGAGAGTTTGTGGA
AAACTGTTCTTTGCTC
14162893 20332517 18446643 NUDT5 NM 014142 (NUDT5), mRNA ILMN 1676448
Homo sapiens XK, KeII blood group complex subunit-related CTGTGTCGCCTCTCCGTGTGGATCTGGCAGTCG
XRG6, C8orf7, C8orf21 family, member 6 (XKR6), GTCATCCACCTGCTGCA transcript variant 2, mRNA
4434806 8263162 6880901 NM 173683
Homo sapiens X-ray repair
GGAGGCTCTGGCTCAAA complementing defective ATCCCAGCTTTGAGGAGGCCCTGATGGACAACC
RCC CAGCAATAGGGTCTTCC repair in Chinese hamster CCTCCCTGGCATTCGTT TCACTGACCTTGGAGG
9751536 17903513 14440594 XRCC1 NM_006297 cells 1 (XRCC1), mRNA ILMN 1790317
Homo sapiens coiled-coil TGTGCTAGGTAGGTGAA
CCCCTTCACCTTCCAGGGACGCAGTTGTTACGA
HSPC009 domain containing 56 CCAGAAACCACCCTCGC
GGTTAGACGTGGCAGCT (CCDC56), mRNA CACCAAGACTCGCTCC
1692406 19428394 18627976 CCDC56 NM_001040431 ILMN 1732187
Homo sapiens HIRA
GCAGCTCCCAAGGACACAAGCTGTTGGGATGCT interacting protein 3 (HIRIP3),
ACTTCTCAGCTTCACGC
14212262 2681726 2217768 NM 003609 mRNA
Homo sapiens stromal cell- GGAGAACCAGCCCAGTA
GCAGGGCCACTCTTGGCAGAGACTTTGGGTTTG derived factor 2-lιke 1 ACATTGTGTCTCTTCAAA TAGGGGTCCTCAAGTGC (SDF2L1), mRNA CTGAGCCATCAAGGC
1364006 2881 1726 2254156 SDF2L1 NM 022044 ILMN 1749218
Homo sapiens centrosomal GCCAGACACAGAAGGAA
GGACTGCTCATCGAGAAGAGATAGCCAGGATCA
FAM68A, KAB, KIAA0470 protein 17OkDa (CEP170), AAATACCAGATGATCCCA GCCAAGATCTTGCTCTC transcript variant beta, mRNA CTTATATGAGGTACC
19714184 37805597 15090594 CEP170 NM_001042404 ILMN 1771494
Homo sapiens ADP-
ACGCTCGTGAGCGTGAG πbosylation factor-like 5A TTAACACGATATCAGCACATTCCCTTGTCATCAT
ARFLP5, ARL5 AAGCCATAAGAGAGAGA (ARL5A), transcript variant 3, CAAGGTGTTGGCTCAG CCGAATTCTGTGGCTC
38898096 48693927 45424762 ARL5A NM 001037174 mRNA ILMN 1666076
Homo sapiens H3 histone, CTTCCTCGGGCTGGGCC
GAGCACTCAACCCAGAAGGCGAAGATAGCTTTT
H3F3A, H33B family 3B (H33B) (H3F3B), TTATCATCCATCACAGGA GGTTGTAGGCGGCTTCC mRNA GTCAGAAAGGGCTCC
45090594 70390594 6245226 H3F3B NM 005324 ILMN 1661266
Homo sapiens sushi-repeat- CCGCGTATAGCTTCTGG
CCAGCGTCGGGAGCAAAGGGACATATGCGAGTG
SRPUL, RESDX containing protein, X-linked 2 CCTGGGCTTGGCCTGGA AACTTGAGCCAGGGCAT (SRPX2), mRNA TTGTTGGACGAGTTCT
17991013 18171844 SRPX2 NM 014467 ILMN 1751956
PMSCL2, PM-ScI, PM/Scl-100, Homo sapiens exosome AGGAGAGAGGTTTGAGT
GACAGAGGCTTCAGGTACAACTGGCCACAGAGA PMSCL, RRP6, p4, Rrp6p, p2, component 10 (EXOSC10), TCTGGGTATCCTCCCTTT TAGTCCTGGAAGACACG P3 transcript variant 1 , mRNA CTGTAACAGCCTCAA
7803518 11779976 10460559 EXOSC10 NM 001001998 ILMN 1685472
Homo sapiens IRNA
GCD10, MGC5029, GcdiOp, methyltransferase 6 homolog CAACGTAACTAAAACATGGCGGGTACCGAAAGG CGI-09 (S cerevisiae) (TRMT6), AGGGCAATTCATGGAAG
50594986 12182262 9248931 TRMT6 NM 015939 mRNA
pOS + no GFs
Probe_Sequeπce Probe_Sequeπce_l Raw XS pOS + 6 GFs Raw Raw Common Synonyms
Genbank Description Probe Id GGGAGAGATCAGAGGTC bA127L202, RP11-127L204, Homo sapiens K1AA1754
ATACTGTGAAGCACCTTT GCCTCCAGAAGCCAAAACCATGCCTGGATCTCC DANGER, bA127L20 (KIAA1754), mRNA CATAGCTTCTCCTΓTGC
GGATAAACGGCAGGG
5374351 17878643 12375393 KIAA1754 NM 033397 ILMN 1771012
Homo sapiens high-mobility
GGCGTCAAGTACATCGT group protein 2-lιke 1
CCAAATCCCTGTCTCTTC GGGGGGTGAAGCTGTCAATGCCACCAGTTGGAC
HMGBCG, THC211630 (HMG2L1), transcript variant CTCCATACATTCTGAGC
23469658 68873795 49915268 HMG2L1 NM 014250 AGCTTCTCTGATGCT 2, mRNA ILMN 1686516 Homo sapiens GCN1 general control of ammo-acid CCCTGTCAGATGAAAATGATTCACAGCTCTGGCA
GCN1. GCN1L, KIAA0219 synthesis 1 -like 1 (yeast) GTTCCCAAGTCTGGGG
5043601 6446809 59294763 GCN1L1 NM 006836 (GCN1L1), mRNA
TGCCTGTGTTTGTGTTG
Homo sapiens apolipoprolein CCCTCTATTATCCACAACAAGCCATCGTGTTTGC
MGC4825, MyO25, FAM121B GTGGGGGTAAGGGGCA O (APOO), mRNA CCAGGTCAGTGGGGAG GTGGTGTGAAGGGACCA
15600595 27013095 22776012 APOO NM 024122 ILMN_1680264
KIAA0078, hHR21, NXP1, Homo sapiens RAD21 TTGCAGTGGTGGATTGA
GCAGCTTTATATTCAATATGATGTGCCTGTAAAC FLJ40596, HRAD21, FLJ25655, homolog (S pombe) (RAD21), GAAGTCCAGTTTGATTTC
CAAGGAGTTTTCcccG SCC1, HR21, MCD1 mRNA ATTGGGACAGACTGC
62083093 13389644 1058406 RAD21 NM 006265 ILMN 1700202
Homo sapiens dolichyl- phosphate CTTTAGGACTGAAAGCTA
CTAAAGGCTACGTCTTCCAGATGGAGATGATTGT
MPDS, CDGIE mannosyltransferase GGCGTCCTCTCCCACAA polypeptide 1 , catalytic TCGGGCAAGACAGTTG AAAAGTCCTGCCCTC
16570393 18335559 17735977 DPMI NM 003859 subunit (DPMI), mRNA ILMN 1763144
Homo sapiens nudix
GGATCCACTAGGGTGAT
FLJ10956, RP11-90M2 1, (nucleoside diphosphate AGGCTGAATGCAAAAGCAGATACAAGATTCCAGC ATGGCTTCAGCAACCAG MGC104352, MTH2 linked moiety X)-type motif 15 TTTCGTCTGTCATCAG GAGGGATTGACTGAGA
16345595 35130176 2807393 NUDT15 NM 018283 (NUDT15), mRNA ILMN 1665775
Homo sapiens OTU domain
GGCCAATGTGGTTATGAACAAGATTTGTATGGTC
CGI-77 containing 6B (0TUD6B),
AGCTTCTGTTCTTTCC
19320595 3538976 27959344 OTUD6B NM 016023 mRNA.
Homo sapiens amine oxidase
TCATCGGGAGGATCGTC
LSD1, KDM1, KIAA0601, (flavin containing) domain 2 GGAGCTTGCCTCCTTTGAATGACCTAGAGCACA ATTGGCCAGTACTCTTCA BHC11O, RP1-184J9 1 (AOF2), transcript variant 2, GGGAGGAACTTGTCCAT GGCCCCTCTGAGACC
5488976 6947226 6347101 AOF2 NM 015013 mRNA ILMN 1657760
PMSCL2, PM-ScI, PM/Scl-100, Homo sapiens exosome
CAGTTTGATCCAAATAAACAGACCCCGTCTGGCA PMSCL, RRP6, p4, Rrpβp, p2, component 10 (EXOSC10), AGAAATGCATTGCAGC
66548926 102398926 8743976 EXOSC10 P3 NM 002685 transcript variant 2, mRNA
Homo sapiens phorbol-12- GGGTACTTGTAGGAATA
CAGCCTAGAGGCAGCTATTTTACCATCTGGTATT
APR, NOXA myrιstate-13-acetate-ιnduced CAATGAGGAGCTTGAAT TATGGTCTAATTTGTA protein 1 (PMAIP1 ), mRNA. GCCACCTTCTGACATG
121860115 87907263 41232263 PMAIP1 NM 021127 ILMN 1696079
Homo sapiens protein tyrosine phosphatase, receptor type, F ATCAGTCCTTATTATCCCAGCTTGCTGAGGGGCA
LAR (PTPRF), transcript variant 2, GGGAGAGCGCCTCTTc
27601428 79290594 54116846 PTPRF NM 130440 mRNA
Homo sapiens RCEI homolog, TCGτcCATGCCMAGTG prenyl protein peptidase (S ATTACATGGGTTTCCCAGCTGTTTGCGCGGCCTT
FACE2, RCE1B, RCE1A cerevisiae, <RCE1), transcript ^^2^ GGAGCACCCACAGAGG variant 2, mRNA
93568535 127922615 11283511 RCE1 NM 001032279 ILMN 1786843
pOS + no GFs
Synonyms Probe Sequence Probe_Sequence_l
Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probejd
Homo sapiens chromosome
TTCATTCAGGAGGG I I I I I I
HsT2329, MGC24180 18 open reading frame 19 75595 GCTCAGGGAACTCCGG
8546019 116 10340178 C18ORF19 NM 152352 (C18orf19), mRNA Homo sapiens solute carrier
FLJ10316, DKFZp76110921, TGCTGCTCTCGGGAAGG family 6, member 15 CAGTGTGAAGTAAGTTCTCATCCAACATTTCTCC NTT73, hv7-3, MGC87066, W- _,„...._. , ACGAAAGTGACCTGCAA
SLC6A15), transcnpt variant GGAGAGAAATGCAACC TGGCCATCCATTCTCC 3
16499748 12060178 56 10531 SLC6A15 NM 182767 1 , mRNA ILMNJ719143
Homo sapiens PHD finger TGATGTGGCTGTTGGGA
ATGCACATTAAAGCCATGcccGAGGATGCTAAG
CGI-72, MGC64923 protein 20-lιke 1 (PHF20L1), AGATGGTGGGGTTTGTT
GGGCAGGATTGGATAGC transcript variant 3, mRNA TGCCAGCTTGGAGTCC
17381429 19227261 19023929 PHF20L1 NM_198513 ILMNJI 703105
Homo sapiens zinc finger,
GCCTACTCTGGTTAAGATGTTCTTTTCCTCAAAG
ZNF376, FLJ21952 DHHC-type containing 6 GTGCCCTAGTGCCATG
7386893 1103 9143 9420226 ZDHHC6 NM_022494 (ZDHHC6), mRNA Homo sapiens tetraspanin 13 TACCTTCAGCCTCCATCAGAATGGAACGAGTTTT
FLJ22934, NET-6, TM4SF13
17 460238 84 81557 4862852 TSPAN13 NM_014399 (TSPAN13), mRNA GAGTAATCAGGAAGTA Homo sapiens leucine rich
TTACGGGAGACACACCCATGGAAAGCCACCTGC
KIAA1580. NGL1. NGL-1 repeat containing 4C CCATGCCTGCTATCGAG
6671953 35 163696 LRRC4C NM_020929 (LRRC4C), mRNA
GCACACGTGCAGCCTAT
KIAA0204, MGC133067, Homo sapiens STE20-lιke AGCATAATTTACTTGGACAACTTCGTAGGTAGCC ATGGGAAAACCTTCCCTC DA16H23 1, STK2, se20-9 kinase (yeast) (SLK), mRNA TTAACTTCTGGCCAAG TGTACCTGCCTCAAA
3270893 58898096 46468097 SLK NM 014720 ILMN 1718633
Homo sapiens septiπ 10 CGCCTGGCCTATTGAAG
GCACTGACTTGACCCCACAAGTGGAAAATTCCC
FLJ11619 (SEPT10), transcript variant 1, G l I I 1 1 AATCTTCAGAGT CACCCGACACCTTTGCT mRNA TTCGACTTTATCAAC
106 15178 23634763 171 78094 Sep-10 NMJ44710 ILMN 1658713
Homo sapiens ephπn-B3 GGTTGGCCACCTCAATCACCAGCCAAGATGGTT
EPLG8, EFL6, LERK8 59 718147 14543512 97 835144 EFNB3 NM 001406 (EFNB3), mRNA GCTTTGTCCACCAGAGG
Homo sapiens RCE1 homolog, prenyl protein peptidase (S CAGGTCCCAGGAGCCACACACTCCCTTCCTCAC
FACE2, RCE1B, RCE1A cerevisiae) (RCE1), transcript TTTGGACTGCTGCTTCT variant 2, mRNA
232 24344 3253018 28596844 RCE1 NM 001032279
Homo sapiens protein
ACTTGCTTTGGAATTTTC phosphatase 1 , regulatory GAGTTCTGGATGAACGACAATCTCCTTGAGAGCT
SDS22 J*-* subUn,7,PPP1R7, £™£™£* GGAGCGACCTCGACGA
682 65594 709 8518 7002143 PPP1R7 NM 002712 ILMN 1766652
Homo sapiens poly(A) binding
CCTTAGTGGCCAGAGAC protein interacting protein 1 GGGGGGAAAAACCCAACTTGGTGAACTCCCAGC
MGC12360 TGACTTCAAGGTTTTATT (PAIP1 ), transcript variant 2, TAAACAACCAAGACTTC CCAGAGACTCCAGAG
35882004 9096088 6220516 PAIP1 NM 182789 mRNA ILMN 1808157
Homo sapiens mediator of GGTATGTGAAGCAAAAG
NFBD1, DKFZp781A0122, TGGGGTCAGGAACTTGAAGGGATGCTTGGAGTG DNA damage checkpoint 1 GGGCAGGTGCACACACC KIAA0170 AGTAGATTTGAGGGTCC (MDC1), mRNA
19860178 39793512 29851428 MDC1 NM 014641 TCCACAGTGACCTCTG ILMNJ1655720
Homo sapiens nuclear VCP- GCTGGGCACTATGCTAA
CCATCAAGCCGGCAGAGAATCCCCCACACGCTC like (NVL), transcript variant 2, GCACTTTGGGAGCAAGA TGAAGGACCCACTTTCA mRNA ACCTCCTACCTTCCAG
8050197 13568095 10973095 NVL NM 206840 ILMN 1690887
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Geπbaπk Description Probe Id
Homo sapiens family with
ACTCTAACAGCTGTCCAG sequence similarity 91 , TCAGAATGGAGTGGACGGTCACCTTCCTCACTT
DKFZp666B104, FLJ23790 TGTTGGTGATTCCAGTG member A1 (FAM91A1), CTTATTGCTAATCTCCA
GACTGTATCTCTGTG
6022267 16300179 107 30179 FAM91A1 NM 144963 mRNA ILMN 1707858
Homo sapiens lectin,
Gal-8, PCTA-1, Po66-CBP, galactoside-binding, soluble, 8 GAAAGTGTACGCCAACTAAGGGACCCACAAAGC PCTA1 (galectin 8) (LGALS8), AGGCAGAGGTAATGCAG transcript variant 4, mRNA
42476013 4995476 467 71844 LGALS8 NM 201545
Homo sapiens ancient TCCCCCGGCGGAGCCAA
TACGCAAGAAGGAGATTCACAGAGAGACGAGCC ubiquitous protein 1 (AUP1 ), CCCTCACTGATGGGAGC CAGGAGGCTGACTGAGC mRNA CCTGGGGTCATCTGTG
234 19345 38803094 3145976 AUP1 NM 181575 ILMN 1658427
Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-
GCTTGCCCAAGGCCACACAGCAAAAGTCACCAA
PRO1304, MGC26839, CI-75Kd coenzyme Q reductase) CTCAAACCTACTTCTTA (NDUFS1), nuclear gene encoding mitochondrial protein, mRNA
60339027 7344124 6883369 NDUFS1 NM 005006
Homo sapiens GDP-manπose
CCCCCATCCCTTCCTCC pyrophosphorylase B CCTGGGACCTGGCGTGGTGGTCGAAGATGGTGT
KIAA1851 CTTACCCAGCTATGATTC (GMPPB), transcript variant 2, GTGTATCCGGCGGTGCA
AGTTGTCTCTGCCCT mRNA
511 37262 1017 006 74970593 GMPPB NM 021971 ILMN 1670076
Homo sapiens La
GGAAAGGCTGCTCTTGC
MGC75174, DKFZp686L13217, nbonucleoprotein domain TTCTCTGCAGGGTAGGTAAGATAGGTCAGTCAA TCTCCCTCCCAGGGCTT MGC117277 family, member 2 (LARP2), GTTGGTAATGCCTGTCC GAGGCTCCCTATACTT
164 5893 327 6726 24674762 LARP2 NM 032239 transcript variant 3, mRNA ILMN 1697081 Homo sapiens SMEK homolog
GTCGAGCATCTCCCCGC
PSY2. FLFL2, FLJ31474, smk1, 2, suppressor of mek1 TCCTTAGATCACCCTTGTAATGTGTTACGGGTCC AGCCAACGGCAAGGGCG KIAA1387 (Dictyostehum) (SMEK2), Al I I I I CCTGGAATCG GCGAGGCTCCGGCCAA
421 5851 4374726 431 2226 SMEK2 NM 020463 mRNA ILMN 1662140
Homo sapiens NMD3 homolog GCTAGCA I I I 1 1 CCAACG
TTGCCAGTTTAGGGCAGTAGCTGCTTTTGTCATA
CGI-07, FLJ21053 (S cerevisiae) (NMD3), AGGGAACTTATTCCGCA AATATCTTCCTACCAC mRNA CGGGCCTACTGTAGG
643 7143 80957263 732 90173 NMD3 NM 015938 ILMN 1750158
Homo sapiens katanin p60 AACGCCCCGGGCAAAGG
TCATATGATGGTACGGCAGCAGGGAGTGGCCCC
MGC2599 subunit A-like 1 (KATNAL1), GTCTTTTGCAGCTTTTGC CAGTTAACATGGCTGTG transcript variant 2, mRNA AGACGGGCAAGAAGC
27335596 637 45593 452 7851 KATNAL1 NM 001014380 ILMN 1753550
Homo sapiens pelota homolog CCGCTTCCCTGTTCCCGAACTTTCTGACCAAGAG
PRO1770, CGM 7 (Drosophila) (PELO), mRNA. GGTGATTCCAGTTCTG
14980143 24272393 1995406 PELO NM 015946
TRIP8. DKFZp761F0118, Homo sapiens jumonji domain CTC I I I I I I GGACATGTG
GTTCCTTGGTGATGCTATTGTTTTGCCAGCGGGA KIAA1380, FLJ14374, RP11- containing 1 C ( JMJD1 C), TCTCTCCACTGCCACAAC GCACTTCATCAGGTTC 10C132 transcript variant 1, mRNA ACCCAAGATGATCA
13541428 49040594 29585596 JMJD1C NM 032776 ILMN 1722496
pOS + no GFs
Synonyms Probe Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description
Homo sapiens DEAH (Asp-Glu CGGCTCTGTTGTTTGAAT
CCCCTTGAAGTAGGGGGACCCTGAATTTGCCCA
KIAA0134, HRH1, DDX34 Ala-His) box polypeptide 34 AAACGTGAACGTGAACC TCCACCTGGGTCACTTT
(DHX34), mRNA CAGGCGGAAGGGACC
50314907 80 52324 6692281 DHX34 NM_014681 ILMN_1663927
Homo sapiens proteasome (prosome, macropain) 26S GCCCAGGGCACTGTCCCCATTTTCCCACACACA
RPN3, P58, S3 subunit, non-ATPase, 3 GCTCATATGCTGCATTC
157 51012 20467679 18451428 PSMD3 NM 002809 (PSMD3), mRNA
Homo sapiens
TTTGGAAGGGCAAGGTGCGAGGATGCTTGAGGC
ASAL argininosucctnate lyase (ASL), CAGGAGTTTGACACAGC transcript variant 1 , mRNA
41 03135 106 53512 72 34765 ASL NM 001024943
TCATGATGTTAAGCTGCC
Homo sapiens leupaxiπ CACGTTTTCCCATTTGCCCTGTGGCTCACTGTCT
LDPL TCTTTCTTCTGAAGGCAC (LPXN), mRNA TTCTTGCTCTTGGG TACAATCACTGCTGTG
29020593 38430308 1301 0143 LPXN NM 004811 ILMN 1673537
Homo sapiens proteasome
FLJ21864, MGC142228, (prosome, macropain) AAAGAGGGCAAGTCCTGAACCTAACCAATGACCT MGC138374, PA200, KIAA0077 activator subunit 4 (PSME4), GATGGATTGCTCGACC
1214 8059 1815 1477 15245393 PSME4 NM 014614 mRNA
Homo sapiens dedicator of TGGGCTGGCTTCCAGTT
Nbla10300, DKFZp781A1532, CCCTAAGTTTGCTGTCAGTTATTGTATGGTCAGT cytokinesis 10 (DOCKIO), TTATGTTTCCCAAATGGT DRIP2, 2IZ3 ACCCCAGTCCTAGTAC mRNA GATTCAGCTGTTCCA
87590594 1971 3394 1404 06 DOCK10 NM 014689 ILMN 1691228
Homo sapiens serpin peptidase inhibitor, clade B GCTGCTGCCCACACCGC
AGGAGCTGAGCATGGTCATTCTGCTTCCCGATG
CAP2, PI8 (ovalbumin), member 8 GTCGACGCCTTCACTGC ACAACACGGACCTCGCC (SERPINB8), transcript variant CATCCCCGCTGTCCTT
246 58511 48535596 362 12262 SERPINB8 NM 002640 1, mRNA ILMN 1738473
Homo sapiens receptor-
CTCGTCTGGCCCATCTA
MGC3597, RNF205, CMS1E, associated protein of the TCCTCGCCACTCCTGCTCTTTCTCCACTGCACGC CCTGCTGACAGAGCATG CMS1D synapse (RAPSN), transcript CAGAGGCCCATTTACT ACAAAGATGACGCTCA
9327301 999893 95626785 RAPSN NM 005055 variant 1 , mRNA ILMN 1707551 Homo sapiens fibronectin leucine rich transmembrane AGTGCATTGTACGCCCTTTGGCCAGTCTTGTATG protein 3 (FLRT3), transcript TGCCTTGATCCAACGC
12910944 432 0476 102 84102 FLRT3 NM 198391 variant 2, mRNA Homo sapiens armadillo
GAGATATGGGTGCCCTT repeat containing, X-linked 6 GGCCTGTAGGTTTCGGCACAAGTTTCAGCGAGA
FLJ20811 TTGTACGTCTAGGCCTA (ARMCX6), transcript variant GAAGGAGAAAACTGCCT GGTAACCAGTGGAGTG
1017 8809 12297393 1130356 ARMCX6 NM 019007 1, mRNA ILMN 1763196
Homo sapiens popeye domain TCTTAACCAGCTGAGGG
MGC22671, bA355M14 1, CAGCCTGAGGGTGGGTTGCTACTGTCCACATAG containing 3 (POPDC3), AGCTTGTACAACACCTTA POP3 GCATTTCCGGAATTCAC mRNA TGTATGCTGGTTGGG
12745178 3104101 21801428 P0PDC3 NM 022361 ILMN 1805148
Homo sapiens 3-hydroxy-3- GTTCCCTCAAAACTGATG
CTTGGATGGACCCACGAACGCTCTTAGCTTTCTC methylglutaryl-Coenzyme A TGGGCACTTGGCCCAGA AGGGGGTCAGCAGAGT reductase (HMGCR), mRNA AGTTGTTTGCTAATG
387 25177 780 5393 5736643 HMGCR NM 000859 ILMN 1782881
pOS + no GFs
Synonyms Probe_Sequence Probe__Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens trinucleotide repeat containing 6B CTAGGCACTTTAGAGGTGCACTTGCATGGCAGG
KIAA1093 (TNRC6B), transcript variant CTGGGCCCCCTTTTCTA
230 30595 244 9851 23595595 TNRC6B NM_015088 1, mRNA
Homo sapiens KTM 2 homolog, CTGGCGGAGATGCTTCT
T0T4, SBBI81, MGC20419, TGGGCTATCACAGAGCATTGACCATTGGCTTCC chromatin associated (S AAGGCATGGTCGGGGGA RP11-91A18 3 CTCATCTGAGGCGTGGG cerevisiae) (KTI12), mRNA GAGGGCCAACAACTGT
2903351 49543097 388276B KTI12 NM_138417 ILMN_1668850
Homo sapiens CTP synthase TCCCCATGCCTGTGCGTGCGCTTCCTATTTCTAG
14873226 25846392 20144727 CTPS NM_001905 (CTPS), mRNA GGCTGGGAAACACTCC
Homo sapiens armadillo
CTAACATTGTCACCTTCTGGAGAGAGAGTTAATG
FU10511, Arcp repeat containing 1 (ARMC1 ), GGGGGCATTGAGGATG
6865226 827 9976 7605393 ARMC1 NM_018120 mRNA
Homo sapiens hypothetical
AGGGCAGCCTCTGTTGGCCTGAGGGTCTGGAC
MGC99481 protein BC002926 GC I I I I IATTTATGCCTA
16494345 366 78928 25631427 LOC90379 NM_138353 (LOC90379), mRNA
Homo sapiens SWI/SNF related, matrix associated,
SNF2L4, BRG1, SWI2, SNF2, GGAGAGTGTTACATGGT actin dependent regulator of CCGTCCACTCCTCCTACTGTATTTTATTGGACAG hSNF2b, BAF190, FLJ39786, GTTGGGGGAAGAAAACC chromatin, subfamily a, GTCAGACTCGCCGGGG SNF2-BETA, SNF2LB TACGCTTCAGGCTCAG member 4 (SMARCA4),
1102 6643 1206281 1177 7476 SMARCA4 NM 003072 mRNA ILMN_1685259
Homo sapiens zinc finger
KOX5, ZNF13 GAGGGCAGGGACTTTGTTGACTGCCAAATCTAC protein 45 (ZNF45), mRNA
86 368546 94 75597 91 164345 ZNF45 TCTGCCTΠTCAGTGCC
AGAGAGAAGTCACCCAA
Homo sapiens DNA helicase
MGC20604 CTGTGAGGAGCTTGAGGAGTTTTGGGTTTACAG GTTCCGCTTCCCCAGGG HEL308 (HEL308), mRNA TGTCCCTAAGCCCCAA AGCCCTTTTGGTAGAAC
5808082 96 18097 76 31546 HEL308 NM 133636 ILMN 1786648
Homo sapiens ubiquitin
MGC120066, MGC120068, GAAGAGAATGCCCAGCTTAATAGCAAGGAGGTA specific peptidase 26 MGC120067 GAGGAGACCCTTCAGAA
448308 58485714 52343422 USP26 NM 031907 (USP26), mRNA
Homo sapiens acyl-CoA hBACH, LACH, LACH1, RP1- thioesterase 7 (ACOT7), CCGAGCACGCTGTAGGGTATGGGAAGAACCCAG 120G22 10, BACH. ACH1, transcript variant hBACHb, MGC1126, ACT, CTE-II CACCACTAATAAAGCTG
20654392 28232144 24467144 ACOT7 NM 181864 mRNA
Homo sapiens ovo-like
HOVO1 1(Drosophιla) (OV0L1), GCCAAACCCCACCTGAAGCAGAACCACTTTGGC
56919904 62 14904 22 580227 0V0L1 NM 004561 mRNA CTCCCCTGCCCAAAATG
Homo sapiens zinc
FLJ14968, STE24, FACE-1, metallopeptidase (STE24 GGGATCAACTGTACGCCTTTGGTATCTGACCATA Ste24p, FACE1 homolog, S cerevisiae) AAGTCTΠTGCTCCGC
25060142 34288977 30797144 ZMPSTE24 NM 005857 (ZMPSTE24), mRNA
GATGAACGAGTCTTGTTT
Homo sapiens high-mobility GTTGAGGCCACTTGGTCCATTAGCTGGGGCAGC
MGC90319, HMG4, HMG2A groupbo,3 «HMGB3, mRNA ^^SS^ST AAGATCACTACTCAACG
95 53514 272 41846 1907976 HMGB3 NM 005342 ILMN_1756424
GGCTCGCTCCAGGACCT
Homo sapiens cyclin D3 GCCCTGTTGACACAGGTCTTTCCTAAGGCTGCA TCTTCACAAGATGACTTG (CCND3), mRNA AGGTTTAGGCTGGTGGC
16606976 2824 7642 2361 5059 CCND3 CTCGCTGTTACCTGC
NM 001760 ILMN 1698019
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens thioredoxin
TMX, DKFZP564E1962, CAATTTCTGTAATGTCCCCTTCTTTCTAGGCTCT domain containing 1 TXNDC GTTGCTGTGTGAATCC
76083923 15163893 11995143 TXNDC1 NM 030755 (TXNDC1), mRNA
Homo sapiens plasminogen activator, urokinase receptor AGTGCCGCAGCCCTGAAGAACAGTGCCTGGATG
UPAR URKR, CD87
(PLAUR), transcript variant 1, TGGTGACCCACTGGATC
15026428 1099731 5624643 PLAUR NM 002659 mRNA
Homo sapiens calmodulin 2
GTTGTTGAAGTGTGGAGTTGTAACTCTGCGTGG
PHKD, CAMII, PHKD2 (phosphorylase kinase, delta) ACTATGGACAGTCAACA
13961072 2678661 21429812 CALM2 NM 001743 (CALM2), mRNA
MGC118913, EVE1,
Homo sapiens SH3 domain GCAGGCCCAGCGATGCC MGC118910, Kryn, SH3P19, CAAGTGGCCACACTTTTACGTGACTACAACCTGG containing 19 (SH3D19), CGCTTCACTCGCCGCTA MGC118911. MGC118912. AGTTCTGCAAAGAAGG mRNA CTGAGTACTTGGAATC
25439761 2893476 27595593 SH3D19 MGC105136, EBP NM 001009555 ILMN 1722059
MGC129748, UNQ8193, Homo sapiens apolipoprolein CAGGTGCAACCCAGTTTATGCCTGACCCCAAGC FAM121A, CXorf33 0-lιke (APOOL), mRNA TCATGGATCACGGGCAG
62020805 10946428 9236513 APOOL NM 198450
MGC997, DXS8237E, Homo sapiens RNA binding
GAGGTGGTGACTTTTGTTGGAAAATTGGGCTGG KIAA0122, ZRANB5, GPATC9, motif protein 10 (RBM10),
GATCACGTCCTGTTTTG GPATCH9, MGC1132 transcript variant 2, mRNA
18341184 24953394 2266306 RBM10 NM 152856
Homo sapiens dual-specificity
ATGAAGGACGAGGTAGC tyrosιne-(Y)-phosphorylatιon AAGTCTGTCCCCAGACCTCTCACCACCATAGACA
DYRK5, hYAK3-2, RED, REDK TCTACTGGCTGCTGTCA regulated kinase 3 (DYRK3), AGGTGTCAGGGAAACG CCCTCCTGGGAGTCCT transcript variant 1 , mRNA
63734966 11405179 925643 DYRK3 NM_003582 ILMN 1668247
Homo sapiens Ras and Rab CCAGTTTGCAGGTGCACAAACTATGAGGGTCTT
RASSF4 6744351 1369106 1071856 RIN2 NM 018993 interactor 2 (RIN2), mRNA GTATCCACGTAACACAG
.„,_ . ,. CCCATCGTTGCTATCACC
Homo sapiens NK3 homeobox AGTACCTCTCAGCTTACT CCATCTTGCTTTCCCCATTGGAACTAGTCATTAA
NKX3A, BAPX2, NKX3, NKX3 1
1 (NKX3-1), mRNA CCCATCTCTGAACTGG
CTTCAGGGGATATG
6803358 13334763 103930954 NKX3-1 NM 006167 ILMN 1698191
Homo sapiens chromosome 1 CATGGGTCTCCAGGAAG
GCCAGCCCAGAGTCAGTCCATCGGGGTTACATT
FLJ20508 open reading frame 109 TGACCTTGGATGGGGGT TCCAAGGTCTGCTGCCT (C1orf109), mRNA GGGAAGGGGCTGCTGG
20039761 21430594 20889345 C1ORF109 NM 017850 ILMN 1764355
Homo sapiens p21 (CDKN1 A)-
TAACACTCTAGCCCCTGCCCTTATTGGGGGACA activated kinase 4 (PAK4), GATGGTCCCTGTCCTGC transcript variant 3, mRNA
18121428 20728094 19633095 PAK4 NM_001014832
Homo sapiens
GAGCCCTTACCAAGGGATCAGGAGCAATGCCAC
MGC13378, MGC12290 lipoyltraπsferase 1 (LIPT1), TGCTAGCATACCTTCCT
53191994 7349957 6687561 LIPT1 NM 015929 transcript variant 1 , mRNA Homo sapiens solute carrier family 36 (proton/ammo acid AGCTCTCTCCAGATCATCCCTGTGAATGCCAAAG
FLJ38932, PAT4 symporter), member 4 TAAACTTTATGTACAG
16993094 24637679 21787262 SLC36A4 NM 152313 (SLC36A4), mRNA Homo sapiens phosphatidylinositol transfer
RDGBB, RDGB-BETA, GCAATCAGCATTCCTCCCCTGTGGATGACATAGA protein, cytoplasmic 1 RDGBB1 GAGTCATGCCCAAACA (PITPNC1), transcript variant
12442679 29348096 22811429 PITPNC1 NM 181671 2, mRNA
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbaπk Description Probe Id
Homo sapiens CDC42 binding
DKFZp686P1738, KIAA0451 CCAAGTCAGCAGTCCTA protein kinase alpha (DMPK- CGACTGGCTTCCTCTCTCAGGTGCTGGATTGTG FLJ23347, DKFZp686L1738, GCCCCAAACCAGCCCAG hke) (CDC42BPA), transcript GGGTTAGTGGCATTTCC PK428, MRCK, MRCKA AGCAGGGTCTCTCTAA variant B, mRNA
12999345 160 33096 14823096 CDC42BPA NM 003607 ILMN 1690170
Homo sapiens toll-like
CCCCACTGTGGCTGATT
MGC35334, TRIF, TICAM-1, receptor adaptor molecule 1 GCTGCAACCCCTCATTATCCACCACGCACAGAT
,τ.^>.», . -, TGGAATTTTGTGCCCCCA PRVTIRB (TlCAMn transcript vaπan.2, TGTAAGCACCCCTTC GGTACAGCTGGGGCTGA
50 945847 7502017 6625397 TICAM1 NM 182919 mRNA ILMN 1794386
Homo sapiens ATP-binding cassette, sub-family C AGACGTTCGGGGCAGGG
ABC37, FLJ36852, SUR2 CCTGGAGGTCTAGATGCGGTTGTCACTGAAGGT (CFTR/MRP), member 9 TGGGAGTGGGTATGGAG CMD1O GGGGAGAATTTTAGCGT (ABCC9), transcript variant ATGCAATTTGGGACTG SUR2A-delta-14, mRNA
11 707075 8948955 46772972 ABCC9 NM 020298 ILMN 1664896
Homo sapiens GDP-mannose pyrophosphorylase B GACCCTGGACTTGTCATTATTTGTCTGGGGGGC
KIAA1851 (GMPPB), transcript variant 2, ACTGGGTGAAGCTGAAG mRNA
70 53033 204 23096 147 19762 GMPPB NM 021971
Homo sapiens mitochondrial ribosomal protein L3 (MRPL3), GTGAAATAGTGGTTGTGGAACAGTAGAAAACCAT
MRL3, RPML3 nuclear gene encoding ATGGGGACTATAGTGC mitochondrial protein, mRNA
45404335 9256014 7518869 MRPL3 NM 007208
Homo sapiens zinc ribbon hZR14, tctex-6, MGC13376, AGTCGGACCTGGATTTCTGTTCAGATTGCGGCT domain containing 1 (ZNRD1 ), Rpa12, HTEX-6 CGGTCCTGCCTCTGCCC transcript variant b, mRNA
1964851 22802678 21791428 ZNRD1 NM 014596
Homo sapiens eukaryotic translation initiation factor 2B, TATCAAAAAGGCCACGG
EIF-2B, DKFZp586J0119, GCGCTGGCTAACTGGCAGAACCACGCATCCCTA subunit 4 delta, 67kDa TCATCGGGTGAACACAG EIF2Bdelta, EIF2B CGGTTGTTGAATCTAGT
(EIF2B4), transcript variant 3, ACCCCTCAGTCCTCCC
12579559 1361406 13292227 EIF2B4 NM 015636 mRNA ILMNJ 758790
Homo sapiens phosphodiesterase 8A AGCCCCCGATCTGCATAGCCTGTGAAAGCCCAC
HsT19550, FLJ16150
(PDE8A), transcript variant 1 , GGGGACATCAGTAACCT
29255331 6614261 5273044 PDE8A NM 002605 mRNA
Homo sapiens UDP-N-acetyl- alpha-D- galactosamme polypeptide N- AGCAACATAGTGAGGATCCCATCTCTACGCCCA
GalNAcT6, GALNAC-T6 acetylgalactosaminyltransfera CCCTCCCCCCGGCAAAA se 6 (GalNAc-T6) (GALNT6), mRNA
15536845 34291846 2662101 GALNT6 NM 007210
Homo sapiens transmembrane
DKFZp547E212, HSPA5BP1 TGGGTGTGTGAGGACATGGGGCTGAAGGACCCT protein 132A (TMEM132A), FLJ20539, GBP, MGC138669 GAGGAGCTTCGCAACTA transcript variant 2, mRNA
1700268 47073096 34055594 TMEM132A NM_178031
Homo sapiens syntaxin 3 GGCCGGTCACAATCCAGCACTCAGACAGAGCCA
STX3A 11737262 30145596 22089345 STX3 NM 004177 (STX3), mRNA AGGCAATATCCTCTTGC
pOS + no GFs Raw XS pOS + 6 GFs Raw Raw Common Synonyms Genbank Probe_Sequence Probe_Sequence_l
Description Probβjd
GCATTTAGGCGGGGACC
Homo sapiens ISG15 ubiquttin ACCTGAAGCAGCAAGTGAGCGGGCTGGAGGGT
UCRP, IFMS, G1P2 ACAACGAATCCGGGAGT like modifier (ISG15), mRNA GTGCAGGACGACCTGTTC TGGCCAGAAGGATCCA
31287677 61123096 49018094 ISG15 NM 005101 ILMN 1803979
Homo sapiens 2-oxoglutarate
GATGAGCTTTGTCTACTT and iron-dependent CAAAAGTTTGTTTGCTTA GACACAGTGAGTCATCACATTTCCTCCCACTGCC
KIAA1612, TPA1, FLJ10826 oxygenase domain containing TGTGGCCTTGTTCCAC CCCCTTCAGCCTCC GFOD1 1 (OGFOD1), mRNA
8083893 8802268 8531226 O NM 018233 ILMN 1769388
FLJ22000, FLJ13976, Homo sapiens coiled-coil CCCTGGCGGGTAAATTA
TGCTTAAAGGCAGAGCCGCCTGGTTGGTCTCCA
DKFZP434L0117, domain containing 21 GGAATCTGCACTATTTTG CCCTGTGCATTGGGAGC
DKFZp434P232 (CCDC21), mRNA GAGGACAAGTAGCAC
42835217 76035995 6470339 CCDC21 NM 022778 ILMN 1724984
Homo sapiens WD repeal
CATGCCAAGAAGATGAGACCGGGGGAGGCGAC
TRM82 domain 4 (WDR4) transcript GCTAAGTTGCTGATCGTG
3523066 7061986 5622285 variant 2, mRNA Homo sapiens B-cell receptor-
CCGTGGCCTGGGACGTG associated protein 29 TACCATTGAGAAGAGCTCCACCAGCAGACCTGA
DKFZp686M2086, BAP29 GCTGGTAGTGTTTGTGT (BCAP29), transcript variant 2, TGCCTATGAACACACAC
GGGAAGCAGCTCAAGA
40662677 6764351 57470593 BCAP29 NM 018844 mRNA ILMN 1697905
Homo sapiens cancer
TCGAATTGGCTCTGACC
KNL1. D40, AF15Q14, susceptibility candidate 5 CTTACCTGGGGCAGCGT CAGGACTGCCATTTCTACCACTAGACCCTTGGAC KIAA1570 (CASC5), transcript variant 2, CACCATTGGAACAACC CTGGACAGTGAGGCCT
21131958 12492678 7360788 CASC5 NM 144508 mRNA ILMN 1691855
FLJ46180, dJ39B172, Homo sapiens chromosome 6 GCCTTGGCAGGGCACAA
TCAGAGCAGAAATGGGGCCTTGGCAGGAATATA KIAA1900, DKFZp686C20164, open reading frame 167 TGACCTTGTCGAAATCCA GCACAAAGGGAAGCCTA DKFZp781C2113 (C6orf167), mRNA CCTGTCAGGACGCCT
25152565 10923095 703501 C6ORF167 NM 198468 ILMN 1800354
CCTTGGGCTGCAGATCC
Homo sapiens zinc finger GCAGACTTACTGTACCTTTGGGAATTTAGGCTGG
BAZ2 ATAAGGACTTCCTGTTCT protein 215 (ZNF215), mRNA AGAGACGTCCATAGCC TGGGTGCCAATGTCC
35 B2373 96 50598 72 8966 ZNF215 NM_013250 ILMN_1732538
Homo sapiens transmembrane GCATTGTGGCTTCTCAGTGGCTTGACAGCATCTT protein 32 (TMEM32), mRNA CCTGGTTGTATGTGGC
1810 9976 2217 8894 20590393 TMEM32 NM_173470
Homo sapiens Smad nuclear
RP3-423B223, dJ423B22 2, CCCAAGGTTGGAAAGCAGGGGAATTTCCCAGTG interacting protein 1 (SNIP1),
FLJ12553 TCCTAGTTTTCCACCAG
122 38928 19567262 16540178 SNIP1 NM_024700 mRNA
TA01, MAP3K16, KIAA1361, Homo sapiens TAO kinase 1 GCCACAGTGAACCAGGAGTCACTGAGCCAATGA
29258165 58965145 46503334 TAOK1 PSK2, MARKK, FLJ14314 NM_020791 (TAOK1), mRNA CTTTACCAGCTGCTGAC
Homo sapiens PRELI domain
CGI-106, MGC87972, PREU, TCATGTCTGAGCCAGGTCTGCTTATTCTCCCATT containing 1 (PRELID1),
PX19 GGGCAGCTGAGGACCG
1270 1976 1513781 14203394 PRELID1 NM 013237 mRNA
Homo sapiens signal
HSD25, DKFZp686F19123, sequence receptor, beta GGGAGGAATCCTGGCTCAGCGGGAGTTTGACAG TRAPB, TLAP (translocon-associated protein GCGATTCTCcccTCATT 21 6143 beta) (SSR2), mRNA
16850476 27776978 23 SSR2 NM 003145
BM600, EBR2, MGC141938, Homo sapiens laminiπ, gamma
CGCTGGGGTTACAATCCAAGACACACTCAACACA MGC138491, LAMB2T. 2 (LAMC2), transcript variant
TTAGACGGCCTCCTGC LAMNB2, EBR2A, B2T 1, mRNA
25775208 8884413 552799 LAMC2 NM 005562
pOS + no GFs Raw XS pOS + 6 GFs Raw Raw Common Synonyms Probe_Sequeπce Probe_Sequencβ_l
Genbank Description Probe Id
Homo sapiens Fas CGGGACCTTGACAACAC
CTCTGAGACTGCTAAGTAGGGGCAGTGATGGTT
GIG3, MORT1, MGC8528 (TNFRSF6)-assocιated via CTGGccccACCCACACG death domain (FADD), mRNA TCCTGCAATATTCACT GCCAGGACGAATTGAGA
623006 9777143 8294976 FADD NM 003824 ILMN 1717295
Homo sapiens furin (paired
PACE, FUR, SPC1. PCSK3 basic amino acid cleaving ACTGTGCCCTGGTGGAGAAAGCACTGACCTGTC
16616013 22875595 20798096 FURIN NM 002569 ATGCCCCCCTCAAACCT enzyme) (FURIN), mRNA Homo sapiens polymerase
RPB12, RPABC4, RPB7 0, (RNA) Il (DNA directed) RPBIOalpha, hRPB7 0, ABC10- GACTACAGGTAACCAAAACCACAGAAAGGGAAA polypeptide K, 7 OkDa CTTTGGATGAGGGGGGC alpha, hsRPBIOa
46664833 9048932 69267075 P0LR2K NM 005034 (POLR2K), mRNA
Homo sapiens chromosome AAGCACATTCCTGCCTCA
C14orf61 AGTGTCTAAGAACGTATTCCCTTTACACGCTGAT 14 open reading frame 145 GGGCCTTTGTACCTGTT CTCCTAGTGGAGAAGG (C14orf145), mRNA GTTCCCTCCACCTGG
12405609 16394762 629B7476 C14ORF145 NM 152446 ILMN 1778382
Homo sapiens TAF5-like RNA polymerase II, p300/CBP-
TGCCTCACTCCCCTCAG associated factor (PCAF)- GAGGGCACCTTCTCTGCTTTTAATCTTTCAGGTT
PAF65B CCCCTGCCGACCTTAGC associated factor, 65kDa TGACTCCTGGCACTGG TTATCTGGGAGAGAAA (TAF5L), transcript variant 1 ,
50690506 7908385 65074554 TAF5L NM 014409 mRNA ILMN 1682459
Homo sapiens six
STMP, PCANAP1, STAMP1, transmembrane epithelial GTGTTGGCCAGTGAGATGAAGTCTCCTCAAAGG IPCA1, IPCA-1 antigen of the prostate 2 AAGGCAGCATGTGTCCT
36069866 37073096 15553513 STEAP2 NM 152999 (STEAP2), mRNA Homo sapiens RNA pseudouπdylate synthase GGACGGGCTTCTAAAGAGACCTGCTCATACTTG
C15orf19, FLJ31409, C18B11 domain containing 2 CTACCTCCTTCCAGTGG
41207263 4936476 46606012 RPUSD2 NM 152260 (RPUSD2), mRNA Homo sapiens proteιn-L-
TGTATGCGCCAGGGCTC isoaspartate (D-aspartate) O- GTGTAAGCTGTGTCCTAGTTCTTGAACAGTTTAT GTTCTCACTGCTTATGTT methyltransferase (PCMT1), GCAGTGCTGCTTTGCC CTTCGGGATTCTGGG
24672227 3473456 30676477 PCMT1 NM 005389 mRNA ILMN 1774584
CTGTCCCAGTGTAGGAA
Homo sapiens KIAA1468 GCAGGAAAGAAGCCCCCAGTAAACACTAAGATG
HsT885, HsT3308, FLJ33841 CAGAGACCCGCCTTAAG (KIAA1468), mRNA GACCTCAAGCCGACTGG AGACTGGATCGCACAC
16052261 22123096 19698929 KIAA1468 NM 020854 ILMN 1727389
Homo sapiens ERO1-lιke (S TCTTCTGTGTCCCTAAGGCCTGGTACAGTGCCAA
ER01 -alpha cerevisiae) (ER01L), mRNA GCACATACTTGGTATC
1597976 30936844 23946844 ER01L NM 014584
Homo sapiens stπatin,
ATAGCCCAAAGAGTATGGTTAACTTCACGCAGCT
MGC125642, SG2NA calmodulin binding protein GCTTTTGCAGAAGCAC
29329708 7822399 54512367 STRN NM 003162 (STRN), mRNA
Homo sapiens calpastatin
GCTGTCCCTCCACTACAGAAACCTCACAGAACAC
MGC9402, BS-17 (CAST), transcript variant 11 , AGCAAAGGATAAGTGC
78179346 85670593 8278601 CAST NM 001042445 mRNA
Homo sapiens general transcription factor ItE, GAGACTGGTCCTGGTTTTGTTCCCTTTGGTACAG
TFIIE-A, FE polypeptide 1 (alpha subunit, ACCTCTTGTCAGTGCT 56kD) (GTF2E1), mRNA
14348929 25496428 20668929 GTF2E1 NM_005513
pOS + no GFs
Synonyms Probe Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens beta 1 ,3- bβta3Glc-T, B3GIC-T, B3GTL, CCCTGGCTGCCTACACCAGTGGAAAAGAGTCTC galactosyltransferase-like GaI-T CAGTTCTGCTCTGGCCT
62819923 214 32262 135 33096 B3GALTL NM 194318 (B3GALTL), mRNA
Homo sapiens FERM domain GGCAGGAACCACCTTCC
FRMD4, KIAA1294, DA295P94, CCCCATCCAGGTGCTATCAGATGACCAGTTACTG containing 4A (FRMD4A), TCCAAGATCCTCACTATG FU10210 CTTAGTTAACTAGGTG mRNA GCAACTGTGGACCCC
18862679 466 90594 33288928 FRMD4A NM 018027 ILMN_1762170
Homo sapiens RUN and SH3 TCTGAGGGTAATATGCCT
GGTGGGCCTGTGGTGATGGTTTGCATCCTTCCT
NESCA, DKFZp761A1822 domain containing 1 (RUSC1), CTGCCCTTTAGTCAGACT cccTTGTCCCAATAAAG mRNA CTGTGCAAATTGTG
13662476 1761 2769 15986643 RUSC1 NM 014328 ILMN 1684447
Homo sapiens
AGCGCTGTTTGCAGCAT
Parib, MGC99619, EMK1, PAR- MAP/microtubule affinity-
CAGGAAGTGAAGCCCTA CCCTGGCCCTTCTCAGTTTTCTCCCACATTCACC 1 regulating kinase 2 (MARK2), CACCCTGGCGTTGGCT CCTGCCCAGAGATTCC transcript variant 3, mRNA
25569949 6099272 44 06006 MARK2 NM 001039468 ILMN 1772302
Homo sapiens solute earner family 11 (proton-coupled CTTCCCGCACAAATTCCA
FLJ37416, NRAMP2, DCT1. GCTCTTGGCTCCCTTGAGGTTCTGCTAGTGGTG divalent metal ion CATAGAGGCCTTCCCAT DMT1 TTAGGAGTGGTTACAAC transporters), member 2 CCAGCTCTACGTGAT
36469345 46760596 4264643 SLC11A2 NM 000617 (SLC11A2), mRNA ILMN 1697919
Homo sapiens mitogen-
SAPK, JNK2B, JNK-55, JNK2, GCGGATGCTGGATGGGC activated protein kinase 9 GGAACTCTCACCTCCGTGGGCCTGAAATGCTTG JNK2BETA, p54aSAPK, p54a, CTGCAGAAACAACACTCA (MAPK9), transcript variant GGAGTTGATGGAACCAA JNK2ALPHA, PRKM9, JNK2A CCACACACACTTCCT JNK2-a2, mRNA
417 98096 47425595 45200595 MAPK9 NM 002752 ILMN 1731287
„.,.«., ACACACCTGCCAACTGC
MGC133081, KIAA0573, INV, Homo sapiens .nversir , ONVS), ACCTATCTTGACCTGCTG AGCCTCTTCTGTGCTGCGTCTCAACTCAGTGAG NPH2, NPHP2, MGC133080 transcript variant 2, mRNA GGCACCTGGGTCπc CAACCTACAGTGTATAC
11695179 13568929 12608928 INVS NM 183245 ILMN 1792885
Homo sapiens sialidase 1 GAGCCCAAGAACACTGG
CTTTAGGACTGAAAGCTAGGCGTCCTCTCCCACA
NEU, SIAL1 (lysosomal sialidase) (NEU1), TGGCCAAAGGATGGTGT AAAAAGTCCTGCCCTC mRNA CTTGTGAAAGGAGGGC
2082976 325 12677 272 5476 NEU1 NM 000434 ILMN 1661076
Homo sapiens AFG3 ATPase
CCTGAATCGCATTCTCTA family gene 3-lιke 1 (yeast) CGGGGATGACTCTGATTGTCCTTCAGCAGGGAT
FU45200, AFG3 CTGGACTCTGGCCTGCT (AFG3L1 ), transcript variant 2, GAGTCTGTTTTGCTCCG TGGAGAGGTGGCAGC
106868454 12653928 115618454 AFG3L1 NM 001031805 mRNA ILMN 1671843
PREDICTED Homo sapiens TCTCTAGAACACATCCAG
CGGGAGGCAACTCAGTGATTGTGGGAAACACTC WD repeat domain 74 GTGTCGGAGCTAAGGTG ATGGGCAGCTGGCAGAA (WDR74), mRNA TTCAGCTCGGCTGTG
181 51428 241 13928 20836429 WDR74 XM 001125771 ILMN 1762407
Homo sapiens chromosome 9
GCCACAGTCACGCCACTGCATTCTATCCTGGGC
MGC10999, RP11-575L7 5 open reading frame 64
AACAGATGGAGACCTTG
8629766 133 59761 107564285 C9ORF64 NM 032307 (C9orf64), mRNA Homo sapiens
MGC20767, HT036, RP11- hydroxypyruvate isomerase TACTTCCTGGACACGCCCCAGCAGGCGGCAGCC 506B155 homolog (E CoIi) (HYI), ATCTTACAGAAGGTAGG
81 1565 2777393 155 10594 HYI NM 031207 mRNA
pOS + no GFs
Synonyms Probe Sequence Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probejd Probe_Sequence_l
Homo sapiens F-box protein CTGGCGGCATGGTGAGC
FLJ12673, PRMT9 UG063H01, GCTGGAGTCTGGGTGACAACTGGCAGCACTCCA 11 (FBXO11), transcript AGAGTGCCCTATCCCAG MGC44383, FBX11, VIT1 GTACTGAGAAGAAACCG variant 2, mRNA TCCCACTTGTGTCAAA
50 83008 7362764 61 11802 FBXO11 NM 018693 ILMN 1659572
Homo sapiens antizyme
ODCU, OAZIN, OAZI, TTGCCATATCTGCAGGAGAGCTGTTCTATAAGAA inhibitor 1 (AZIN1), transcript MGC3832, MGC691 ATAGCTCAGAGTTGCA
177 76428 257 2726 212 11429 AZIN1 NM 148174 variant 2, mRNA Homo sapiens fasciculatioπ
AGACTTCCCTACTGAGC and elongation protein zeta 2 AGTGTGTGTCCTCTGAGGTGCTTGAGAAAGTGT
MGC117372, HUM3CL CACCTTCTCTGCCACGAA (zygiπ II) (FEZ2), transcript ACACTGCAGAACTGCCC
CCGGTCGGGCTAGGA
32655476 3877 7476 35489644 FEZ2 NM 005102 variant 1 , mRNA ILMN_1777663
MGC134848, MGC102894,
Homo sapiens capπn family
MGC134847, FLJ11391, caprm- GGACAAGGAGACTCCCGTAGCATGACCCCTGTG member 2 (CAPRIN2),
2, C1QDC1, EEG-1, FLJ22569, GATGTGCCAGTGACAAA transcript variant 2, mRNA
7641078 1282976 103 59079 CAPRIN2 EEG1 NM_023925
Homo sapiens PDS5
AS3, PDS5B, FLJ23236, RP1- CACTGCAGAGAGCCAAT regulator of cohesion CTTGCTGCAGTGCAACAGGAGGC I I I I I CAGTG 267P19 1, KIAA0979, APRIN, CAGACGTCGCAGAGCCC maintenance, homolog B (S ATCTTCACTGTATATGT CG008 CGACGACACTATGCTT cerevisiae) (PDS5B), mRNA
6523072 9026953 75491394 PDS5B NM 015032 ILMN 1767343
Homo sapiens procollagen C-
CAGAGGAGCAGCTATCTGATTGGAAACCTGCCG
PCPE2 endopeptidase enhancer 2 ACTTAGTGCGGTGATAG
133 3451 1190356 25939346 PC0LCE2 NM 013363 (PC0LCE2), mRNA
Homo sapiens COP9 constitutive photomorphogeπic
COP9, MGC43256, MGC1297, CCCCCACCTCCTGAGAGCCACTAATGTAAGATAC homolog subunit 8 CSN8, SGN8 AGAAACATAGCTGAGG (Arabidopsis) (COPS8), transcript variant 1 , mRNA
32647263 417 87262 36558093 COPS8 NM 006710
Homo sapiens Rho GDP ACCCGACTCCGCATGTT
GDIA1, RHOGDI-1, CAGGCCTTCCCTGACCCAGCCAGGAACAAACAA dissociation inhibitor (GDI) TGCGTCTGTTTCCTCCCT MGC117248, RHOGDI GGGACCAAGTGCACACA alpha (ARHGDIA), mRNA CTCTGGCCCTGTCTT
43130312 5972 9727 5009 164 ARHGDIA ILMN 1798867
Homo sapiens guanine nucleotide binding protein (G GTTTGGTTCCTCCCGGGGCCCCCACTGTGGAGA protein), beta polypeptide 2 TAAGAAGGGGATGGAAT (GNB2), mRNA
34934344 39229346 36628513 GNB2 NM 005273
Homo sapiens chromosome 9 TGCAAGGGACAGGGGGC
CTTCTGTCCCCCTTATGCCAACAAGATGGCCTTC
CG-8, FLJ20457 open reading frame 6 CTGACTACCCAGTCTTTG CCCTCTGAAACAAAGT
(C9orf6), mRNA ACTTGTATCCTCTCC
12378928 221 89761 16255594 C9ORF6 NM 017832 ILMN 1749006
Homo sapiens synaptojanin 1
AAGTCAGTGGTACACAGACATTCTGTACATATCC
INPP5G (SYNJ1 ), transcript variant 2, TGTGAAACGTGCTGTC
111 08511 217 31429 151 24345 SYNJ1 NM 203446 mRNA
Homo sapiens glutamine-rich
AATCTCCCCAGCCGACTTCCACTGGGCTGACAG
FLJ20259, MGC131838 1 (QRICH1), transcript variant
95994763 1160781 1051 9309 QRICH1 ACTTTGCTGACCACAGG
NM 017730 L mRNA
Homo sapiens transmembrane GTACTGCTTTCAGTGTGT
CTTGTGTTGCAAGGGCAACCTCGTCCATTTTAAC
FLJ13391 protein 166 (TMEM166), TCCCCCTCAGCCCCTCC TGGCACCTCAGGGATT mRNA GGCGTGTCAGGCATA
884 95593 1847 8809 1258581 TMEM166 NM 032181 ILMN_1652722
pOS + no GFs
Synonyms Probe Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
DKFZp686M1969, FLJ90492,
Homo sapiens transmembrane TTCCATACTGCAAGGGC DKFZp686O2342, CTGATACCAGTGGGAGTTGGTCTTGATCTAGGA and tetratricopeptide repeat AACGTCATACCCCACAC DKFZp686O22167, GATTCTGTTAAGCATCC containing 3 (TMTC3), mRNA CTACTGTGACCACATG DKFZp686C0968, SMILE
131 62679 262 1518 182 15594 TMTC3 NM 181783 ILMN 1770442
GATGATGGCTGATGTGT
Homo sapiens zinc finger GGGGGACGGTCCAGGAACCAATACCCCATGGAT
FLJ20582, PRO1914 protein 770 (ZNF770), mRNA f Ξc ACCAAGGGACAACTGTA
227 68929 26726843 24573929 ZNF770 ILMN 1676774
Homo sapiens family with GGACCCAAGGCTCAGAA
GTGTGCAGCTGACCCAAGGCAGCCACATCTGCG
MGC29729 sequence similarity 58, GGACCGAGTCATAAAGT TTTGTCCTTTGAGAGGA member A (FAM58A), mRNA GTGAATGGCATAGAGG
37344345 46293097 41387262 NM 152274 ILMN 1714739
Homo sapiens glucosamine- CCACTAGCCCCTTACCC
GGTGATCTTAGATTTGATGAAGCACAGTATGCAG
Gpnatl, GNPNAT, FLJ10607 phosphate N-acetyltransferase AGAGTGGCCCACAGGAA GTAGGCCTAATGGGGG
I (GNPNAT1), mRNA ACAGCCTGCACCATTT
71 61555 18242262 11304346 GNPNAT1 NM 198066 ILMN 1699599
Homo sapiens πuπm (nuclear TATGAAGAGAAGCCCTCT
GTCTGCAAGTTCAACGGTCATAGCTGTCCCTCCA
NRM29 envelope membrane protein) GCTGTGTGTCCGTGGTG GGCCCCAACCTTGCCT (NRM), mRNA AGTTCTGGGGTGCGC
59 11771 166 31012 94493515 NRM NM 007243 ILMN 1807206
Homo sapiens chromosome
CAGAGCTGGCATTTGCACAAACACGGCAACACT
C11orf3, HT022, 0RF1-FL1 15 open reading frame 24 GGGTGGCATCCAAGTCT
3423356 40845396 3712 7559 C15ORF24 NM 020154 (C15orf24), mRNA
Homo sapiens protein kinase,
CAR, PPNAD1. MGC17251, cAMP-depeπdent, regulatory,
CTGCTCTAGAAAGTATAGATGGCCAAAGGACCG TSE1. CNC, CNC1. PKR1, type I, alpha (tissue specific TTTTGTATTGCTTCCTG PRKAR1, DKFZp779L0468 extinguisher 1) (PRKAR1 A), transcript variant 1, mRNA
23755642 25368809 2495931 PRKAR1A NM 002734
Homo sapiens ankyrin repeat
TGTTTTCACCCCCACCCTCACTGGAATTCTCACC
KIAA1223 domain 50 (ANKRD50), AAAAATAGTTTGATAC
24708095 402 9893 30843097 ANKRD50 NM 020337 mRNA
Homo sapiens activity-
CTGGCTGTCCTATGTCC dependent neuroprotector GCACATAACCTTGTACAATCTTGCAACAGAGGCC
ADNP1, KIAA0784 AGGAAGAAGCCCATTTG homeobox (ADNP), transcript 2^"7T"?2""""I_! ' ' AGCCACGTAAGATATA
, _ nlli TTGAGGCTGACCTTCC „ .... H-^«««o
3260893 47565594 38837677 ADNP NM 181442 variant 2, mRNA ILMN_1743303
Homo sapiens B-cell receptor- associated protein 29 CCATTGAGAAGAGCTCCACCAGCAGACCTGATG
BAP29, DKFZp686M2086 (BCAP29), transcript variant 1 , CCTATGAACACACACAG
417 86847 8670143 582 5143 BCAP29 NM 001008405 mRNA
PRO1080, HEDJ, ABBP-2, Homo sapiens DnaJ (Hsp40) TTGGGGCAGTCAGGCAT
ACCTCTCCCTTTGGGGATTTAATGTCTGGTGCTG UNQ537, hDj9, EDJ, ERdj3. homolog, subfamily B, member TTGTATCTTTGGTAGGGC CCGCCTGAGTTTCAAG ERj3, ABBP2 I 1 (DNAJB11 ), mRNA AACAAGTAAAACATG
17666143 3042081 2264 8477 DNAJB11 NM 016306 ILMN 1700257
Homo sapiens transmembrane
TGCCTTGAAGTTTACCTTGTGCTGGAGAGCCTTA
TTMC protein 200A (TMEM200A), TGATAACTCCAAAGAC mRNA
7895018 29906978 15809976 TMEM200A NM 052913
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens thioredoxin
CACCAGGTGGTCTCCTC
UNQ364, ERP46, MGC3178, domain containing 5 GAGGACGGACAGGACCCGCACAGCAAGCACCT TGACTTCAACAGCGACA EπdoPDI (TXNDC5), transcript variant GTACACGGCCGACATGTT CCCACTCCTCCACCTT
17823096 22892262 2006726 TXNDC5 NM 030810 1, mRNA ILMN 2038778
Homo sapiens A kinase
AATGGCCCTGCTGTGTCAGTTTCCCTGTGGCCT
AKAP95, DKFZp586B1222 (PRKA) anchor protein 8 TTTGAACTGTACATCTC
162 59344 2253601 1950893 AKAP8 NM 005858 (AKAP8), mRNA
Homo sapiens vascular
GGAGAAAATCCAACCAG
VPF, VEGF-A, MGC70609, endothelial growth factor A ATTTAATTTTGCTAACACTCAGCTCTGCCCTCCC
CTCTTCAGGAGAAGCAC VEGF (VEGFA), transcript variant 3, CGATCCCCTGGCTCCC
GCCATGAAACAGGCCG
20 54899 82 18157 42857296 VEGFA NM 001025367 mRNA ILMN 1755536
FEM1A, EUROIMAGE686608 Homo sapiens fem-1 homolog AGACCATTTCTGCAGTTT
GcccTTATGTGTCACTAAACAACTAGTTTCTCTC
KIAA1785, c (C elegans) (FEM1C), GCCCAAACCTCTACTGTT
CCTTTTGTCAGTTCCC
EUROIMAGE783647 mRNA TGGGACAGTAAGCC
404 1726 5552351 477 35596 FEM1C NM 020177 ILMN 1773643
Homo sapiens nuclear
GATCCCAGAGGCTGAGG
MGC20369, NFX2, transcription factor, X-box CCCCCTGAATGTACCCAAACCTGCGCTAGAGTC GTTGGGGGGAGGAAGC DKFZp779G2416 binding 1 (NFX1), transcript CATGAGTGTGACCATCC
CATCATCTCATTACCTC
11245178 13371011 12472679 NFX1 NM 147133 variant 2, mRNA ILMN 1672081 Homo sapiens Sec61 gamma
GCTACGTGTCCCTGGCATTTTAGGTGTCGGTTG
SSS1 subunit (SEC61G), transcript
GGCAGTCATGGATCAGG
7813531 11723 522 9620764 SEC61G NM 001012456 variant 2, mRNA PREDICTED Homo sapiens
CCTGGGTCCACCAGCCCCTGACGCCCCTGTGCC WD repeat domain 74 CACTTTGTAAATAAACT
297 98096 36623926 3339893 WDR74 XM 001125771 (WDR74), mRNA Homo sapiens WD repeat and
GGAGGCCAGTGTAACGTTACATGACTCGTTGAG
SBA2, MGC10210 SOCS box-containing 2 AAAGTTGAGGAATTTCC
10868143 15166685 12920435 WSB2 NM 018639 (WSB2), mRNA Homo sapiens ethanolamiπe
GCACGATTCTGTGACTG I I I I I
EKH1 EKI, Nbla10396 kinase 1 (ETNK1 ), transcript TTCGTTGAGTGTAAGC
167 31012 25261429 20835596 ETNK1 NM 018638 variant 1 , mRNA
Homo sapiens AGAGTCCTGGGGAGCTT
GGTCTTACAGCCTTCCAAAATAACTCCAGTTGGG
MSTP006, FLJ10983 phosphoglucomutase 2 CTGTCCACCTGTCCTGC CACCCATGAGCTAGGA (PGM2), mRNA AGAGGAGTCGTTTCCA
17926428 5086643 31266013 PGM2 NM 018290 ILMN 1661589
Homo sapiens APC11 anaphase promoting complex CAGCCATCTTCTGTAAG
HSPC214, MGC882, Apc11p, AATGGAAGTTCAAGGAGTGAGGCCCGACCTGGC subunit 11 homolog (yeast) GGTGCCCAGTGTGACTT APC11 TCTCGCTGGAGGGGCAT (ANAPC11 ), transcript variant CGGTTGATCCTGCTGC 4, mRNA
8222893 88061426 850 83093 ANAPC11 NM 001002246 ILMN 1694799
Homo sapiens TAR (HIV-1) TCATTCCTTGGCTGAGG
TRP-185, FLJ30482, TRP185, GAAATTCCTCAACAGGGCATTATCCGCTCCCTGA RNA binding protein 1 GAGAGGCTGAGAACTGG TRM3 ATGTCCATGTGAGTGG (TARBP1), mRNA GCAGACACCCCTGGAG
75286316 116 97678 936893 TARBP1 NM 005646 ILMN 1795845
Homo sapiens chromosome 1
FLJ35382, RP4-671D7 1, TAGCCACTGCAGCCTTCTTAAGCTTAGTGTTTGC open reading frame 55 (JJ671D7 1 ACAGTATACCTCTTTC
230 33511 39376013 29993097 C1ORF55 NM_152608 (C1orf55). mRNA
Homo sapiens low density CTTCTCTTCAAGCTGCGC
MANSC3, FLJ14735, AGGCAAATCATTCCCACCATCACTTAACGCCGG lipoprotein receptor-related CCACCCCGACCACACCA bA350J203, MGC39092 GATTATACACATTCTAG protein 11 (LRP11), mRNA AGGAAGccGCCGAGG
33982263 62002673 461 2268 LRP11 NM 032832 ILMN 1813719
pOS + no GFs
Synonyms _ . , Probβ_Sequence Probe_Sequence_l Raw XS pOS * 6 GFs Raw Raw Common ' ' Geπbaπk Description Probe Id
Homo sapiens zinc finger ACTGTACCCGGCATGAGAAAACCCACTCAGCCT
MGC45293 protein 200 (ZNF200),
GTAAGACCCGAAAGCAG
6841696 4857859 ZNF200 NM_198088 transcript variant 3, mRNA
MDSRP, MDS010, C3orf9, Homo sapiens KTEL (Lys-Tyr-
GGATTTCAGGTTCCC I 1 1 1 I MGC32995, hCLP46, CLP46, Glu-Leu) containing 1 TACTTCTTAATGCCTC
89923096 1138 3893 101080597 KTELC1 KDELCL1 NM 020231 (KTELC1), mRNA Homo sapiens TAR (HIV-I) RNA binding protein 2 CTGATGATGACCACTTCTCCATTGGTGTGGGCTC
TRBP1. TRBP, TRBP2 (TARBP2), transcript variant 2, CCGCCTGGATGGTCTT
197 60178 234 52261 21520595 TARBP2 NM_134324 mRNA
Homo sapiens chromosome CCTCGAGGACTCTCTGC
GAGGCTCTCCATGGAAGGATGAACACATATGAG
FLJ13490 10 open reading frame 88 GTCTCTGGAGACAAGGG TCAAGGGATTGCAATTC (C10orf88), mRNA CACTACACGCACTTCA
7723142 211 53513 127 91428 C10ORF88 NM_024942 ILMN 1676689
Homo sapiens similar to HIV TAT specific factor 1 , cofactor
CTTTAGGACACAGCCTTGCATAAGAGCCGTGAA required for Tat activation of GAACTTGGGGCAGTTGC HIV-1 transcription (LOC401233), mRNA
48435146 13348096 83 31879 LOC401233 NM_001013680
Homo sapiens abhydrolase GCCTTCGGTTGTAAGTA
AGGTATGTTCTGAGTGAACCCACAGCAGTCGCA domain containing 6 (ABHD6), GCCAGATCCCTCTCCAG GAATGAGCACCTGGCAG mRNA TGACATTGGAACATGC
47609894 7578342 59 948616 ABHD6 NM_020676 ILMN 1687375
Homo sapiens ATPasβ, H+ transporting, lysosomal CTCTGGAGGATTTGGGG
GGCCCTCCCTGCACTCCCCTCTTGCTGCGTGTT
HATPL, ATP6F, VMA16 21 kDa, VO subunit b TGCCCCTCTCGGCAGGG GATTTGGAGGCACTGCA
(ATP6V0B), transcript variant AACAGGAAGTAGGAAT
2172 3975 3349 0059 2703 7227 ATP6V0B NM_004047 1, mRNA ILMN 1813374
CTCCCTTGGGGTGGGAA
Homo sapiens transmembrane TCTATGATGGAGGTTACT GGCTGATGGCCTCTACCTTTGTATCCAGGAGAA protem 2 (TMEM2), mRNA GGGGAAACAGCTCAG ACTGCAGAGCAGCCCTG
5250018 7202643 61957263 TMEM2 NM_013390 ILMN 1705035
Homo sapiens TNF receptor-
TATTAGTGCGCTGTGAGGTCTCCACCCGCTTTGA
MGC 3310, RNF85 associated factor 6 (TRAF6), CATGGGTAGCCTTCGG transcript variant 2, mRNA
127 314285 10072284 TRAF6 NM_004620
Homo sapiens family with GTAACCACGGGGTCCAT
NPD008. YDR084C, FLJ46240, AGGTGCCAACCTGTATGGTTACATCAGGTGTAA sequence similarity 18, CTTTTACATCTGGTACAC CGI-148 GGTGCGCAGCAGAAAGC member B (FAM18B), mRNA ACAACAGACGCTCAG
311 9226 347 7226 325 81845 FAM18B NM_016078 ILMN 1732468
Homo sapiens AT rich
GGCAGACCTGACTCTCT
E2FBP1. DRIL3, BRIGHT, interactive domain 3A CCACACACTCACCACTCCCAGCTTCTCGTGTCCA TAAGGAGGCTGAGAGCC DRIL1 (BRIGHT-hke) (ARID3A), GTGAAACCCCTGAACC CAAACTGCTGTCCCAA
26972263 644381 391 3601 ARID3A NMJ305224 mRNA ILMN 1768482
Homo sapiens prolactin
TGGCATTTGCTGGGGAAGGGACTGGCCTGGTAC
SEC 12, MGC3467 regulatory element binding TTGCTGTTAGGGCAGGA
237 28929 501 38095 317 16428 PREB NM_013388 (PREB). mRNA
Homo sapiens ubiquitin-hke GATGGTGTGGGGGGTTG
MOP-4, UBE1L2, UBA6, GCCATGATTTCTTCTGTTTGGTTCTACTAAGCTA modifier activating enzyme 6 GAGTTTTCTTCTAATACC FLJ10808, FLJ23367 GAAAGCCAGGGTGAAG (UBA6), mRNA GAGGGTTCCTGGCTG
3553393 1111 4185 56321423 UBA6 NM 018227
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequence_l Raw XS pOS * 6 GFs Raw Raw Common Genbank Description Probe Id
Homo sapiens endoplasmic
MGC163279, IRE1, IRE1P, reticulum to nucleus signalling ACTGACATGTGTGTGCCTGAGTGCCAGCCACCG FLJ30999, MGC163277 1 (ERN1), transcript variant 2, TGTGAACTCTTTGGAGG
64 37612 151 12679 94044495 ERN1 NM 152461 mRNA
AGGTTCAGGTGTAGCGT
SKIIP, Prp45, SKIP, NCOA-62, Homo sapiens SNW domain TCTGGGTGCCAGATCCCAGCACTAC i
CCCTGGAGGTTGACTGT Bx42, MGC119379, PRPF45 containing 1 (SNW1), mRNA CTGGAGAAATGGGGGG GCCAAAGAGGGCAATC
130 14761 17864345 143 72261 SNW1 NM 012245 ILMN_1751164
CGACCGTTGCGAGACGT
Homo sapiens centauriπ, delta CATTCTGGGACTACCGTGAAGCCTGGAGTAGGG
FLJ21065, ARAP3, DRAG1 TGAGCTGCGGAAGATGA 3 (CENTD3), mRNA AGAGCGAGTTTGGGAGC GTCCAAAGCCGAGAGC
19986429 192 48929 CENTD3 ILMN 1651789
Homo sapiens v-ral simian
CACCTGTAATCCGACTGT leukemia viral oncogene GCTTTGAGACCTTTCCTCTCCTGGGTACTGAGGT
MGC48949, RAL AAGCTCATCACCTTGGG homolog A (ras related) GCTATGAAGCCAACTG
AGGCCACTGTAGGAG
1923 5309 7437 856 32082976 RALA NM_005402 (RALA), mRNA ILMN 1669201 Homo sapiens utrophin ACCGCACGACACCAGCACGGATCTCACGGAGGT
DRP, DRP1, DMDL, FLJ23678
4624128 57 777557 50697205 UTRN NM_007124 (UTRN), mRNA CATGGAGCAGATTCACA
Homo sapiens TDP-glucose GTCCTCTCCATCATCCTC
CCTGATTCGGACAACCATGAGGGGTAGTGGTGC
TDPGD 4,6-dehydratase (TGDS), AGTGTGAGTCCTCAGAG TAGGGAGAAGGCAACCT mRNA CCTCCATCTGCCAAG
204 14761 28845593 23433511 TGDS NM_014305 ILMN 1661695
PKCI2, FKBP12C, PPIASE. Homo sapiens FK506 binding
CTGTCCCTGGGCCAGCAGGGACCTCTGAAGCCT PKC12, FKBP-12, FKBP1, protein 1A, 12kDa (FKBP1A), TCTTTGTGGCC I I I I I I FKBP12 transcript variant 12B, mRNA
27153726 4372 927 3372281 FKBP1A NM_000801
Homo sapiens argmine/proline
GGTACCCATGCCCCCTGCCCTCGCCTGGAATCA
PARCC1, FLJ10350 rich coiled-coil 1 (RPRC1), GTGTTACTGCATCTGAT
3417 9644 5128006 4050 8228 RPRC1 NM_018067 mRNA
AAATACTGGTGATGCTCC
Homo sapiens KIAA1279 AGATTCCTTGTAAGAAAAAATGCTGGGTAATGTA DKFZP586B0923, KBP, TTC20 CTAGAGCAGGAGGCCCG (KIAA1279), mRNA CCTGGTAACAAGCCTG GAAGTGCTGACGCAG
9523512 117 95595 10520596 KIAA1279 NM 015634 ILMNJ 758392
Homo sapiens acyl-Coenzyme A dehydrogenase, C-4 to C-12
GACTGTTGGTCTCTAGGTAGCCTTTGGTCTATTG
MCADH, ACAD1, MCAD straight chain (ACADM), TACACAATCTCATTTC nuclear gene encoding mitochondrial protein, mRNA
9339309 113956 10154851 ACADM NM 000016
FLJ20283, MGC26191, Homo sapiens dipeptidyl- CGGAACATATCCAGTACT
GGGTCACCCTGACCAGAATGAACAGGGCTATTA MSTP141, FLJ14920, DPRP1, peptidase 8 (DPP8), transcript CCTGGTTCCTAGGTGAG
CTTAGGATCTGTGGCCA DP8 variant 2, mRNA CAGGTGATGCCCCAG
371 78928 5424143 4346143 DPP8 NM 017743 ILMN 1675939
Homo sapiens Rho-
TTAAACTTCTGGGTCCG
P160ROCK, MGC131603, associated, coiled-coil GTGCACATAGGAATGAGCTTCAGATGCAGTTGG
GTGCTAGTCAAACAGGA MGC43611 containing protein kinase 1 ccAGCAAAGAGAGTGAT GCTGGGGGAGGCTCGG
19521428 342 32678 25028513 ROCK1 NM 005406 (ROCK1), mRNA ILMN 1661490 Homo sapiens tuftβlm
GTGTACTCTCACGACTG interacting protein 11 GTCTTCATGCCCGTCATTGGGAAGCGACACGAA
FLJ22086, TIP39, bK445C96 GCTAAGACTTGCTGGAC (TFIP11 ), transcript variant 2, GGGAAGCAGCTCTACAC
TGACACCTATGGCTGG
297 73096 393 12677 337 5476 TFIP11 NM 012143 mRNA ILMNJ762810
pOS + no GFs
Synonyms Probe Sequence Probe_SequenceJ Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probe Id
GAATGGCAGGACCCTGA
Homo sapiens hect domain TCACCTTCCTCTGTACACTTGGAAATGCCTCTGG
KIAA0032 GTTGATGAGAGACGTGG and RLD 3 (HERC3), mRNA CTTGTTGCAGCCCTCC AAGCAGCCACAGGGCA
31 612083 271 9101 81 1853 HERC3 NM 014606 ILMN 1729827
Homo sapiens ∞iled-coil domain containing 50 CTCCTGTGTTTGCATTCCTGGGATTTATCCTCAA
C3orf6, DFNA44, YMER (CCDC50), transcript variant GTGCATTTCTGACCAT
1980 8394 30207017 23547976 CCDC50 NM 174908 1, mRNA
Homo sapiens mitochondrial ribosomal protein L43
ACCCTCTAGCTCCCATTG
MGC48892, bMRP36a, (MRPL43), nuclear gene
GCTGAAGACACTGAAGT AATACCTTAACGGGGCTGTGCGCGAGGAGAGCA MGC17989 encoding mitochondrial
AGCCCACCCCTGCAG TCCACTGCAAGTCGGTC protein, transcript variant 1 ,
33922678 421 76843 371 5851 MRPL43 NM 032112 mRNA ILMN 1659462
GGAGCCAGGCCCCCGCT
Homo sapiens msh homeobox TCAGTCAAGACCTGCCTA GGTCCCCAGCAGAATTGACAGTTGAACAGAGCT
HOX7, HYD1 1 (MSX1), mRNA AGAGGCCATGTCTCCTG
GAAAAAGGAAGTGGA
1260 5977 2879 1643 1856481 MSX1 NM 002448 ILMN 1699170
Homo sapiens transmembrane
ACCCTCAATCTCCTCGGCGTCTTTGGAAGATCC
MGC2963 protein 93 (TMEM93), GAGGCCCAGGACTGGTG transcript variant 1 , mRNA
114276794 13877261 12268095 TMEM93 NM 001014764
Homo sapiens RAN binding TTCTCCCTGCAAAGCAGCTCAACAAGAGAAAAAG protein 6 (RANBP6), mRNA CTCTAGTTATAGGGCT
22 742645 76266525 3763667 RANBP6 NM 012416
Homo sapiens alkB, alkylation
AGTCAGTCCAAGGAGGTATGTTCTTCCACAACAG alkB, hABH, ALKBH, ABH repair homolog 1 (E coll) CCTTCTCAGCCTCTGC
107 59761 16943929 1337768 ALKBH1 NM 006020 (ALKBH1), mRNA
GGAGGAGGGGACCCATA
Necl-5, HVED. NECL5, TAGE4, Homo sapiens poliovirus GAGCCGGGAACAGAGAAGTGTGGGGAAGAGAT GGACGCGTTAACATGGA PVS, CD155 receptor (PVR), mRNA AGGAACCAGCAGGATGGC CCTGGAAAACAAAGTG
28078094 324 95178 298 5518 PVR NM 006505 ILMN 1679546
Homo sapiens yrdC domain GTCTTCAGCTTCTTGGCC
RP11-109P144, FLJ23476, GGTGTAATAGTGGGATGTCTGCTTAGTTGGCAG containing (E coll) (YRDC), AACTTAGTTTGCCACAGA SUA5, DRIP3, IRIP, FLJ26165 GGGTTCAGTCCAAATGG mRNA GATTGTTCTTTTGC
47565594 11459644 6998268 YRDC NM_024640 I LMNJ 798636
Homo sapiens elongation
C19orf17, ELLJHUMAN, CCTCTGCCCTGGGAACCAGTCCAAGGGGCTGTC factor RNA polymerase Il DKFZp434l1916, ELL1, Meπ NM 006532 AGTTGAATTTGCCTTTT
14033095 17037262 152 71844 ELL (ELL), mRNA
Homo sapiens CaS-Br-M GCCTGGCGTCTGTCCTG
C-CBL, CBL2, RNF55 (murine) ecotropic retroviral GCCCCGCCTGTCAGAAG GTCCTCCTTATTCAAGATTTTGAAATTCTTAGCCT jransforming sequence (CBL), ATGAACATGTATAGTG GGGAGTGCTGGAGAG
2934226 43937262 3509226 CBL NM 005188 ILMN 1707748
Homo sapiens myotubularin
TGCTCACAGGTGGACTGAGAAATCAGTTACATCT related protein 6 (MTMR6), TAAGTGACCTACAGGG
5307643 10259601 710 1476 MTMR6 NM 004685 mRNA
Homo sapiens chromosome CCCCCCAGCCCCTGCCA
TGGCCAATATTTGTGcccTCTGGACTTTAGTAGG
FLJ38170, FBP2, FLJ12799 14 open reading frame 135 GCTCCACACTATCTCTTA
CTTTGGTAAATGTGAG (C14orf135), mRNA GCTGAG I I 1 1 I GCAA
6599518 93547266 771 90173 C14ORF135 NM 022495 ILMN 1798885
pOS + no GFs
Synonyms escription Probe.Sβquencβ probeJd Probe_Sequencβ_l Raw XS pOS * 6 GFs Raw Raw Common Genbank D
Homo sap,ens fibronectin type GGTGTGGGAGATGTGAG
KIAA0970, DA203I16 5, FNDC3,
GTGCCACATTTGGCAGTACAAATGAGTCTGAGT RP11-203116 5, bA203H6 1 , 1T!, °° 9 ACCATTCTGAGGTCAGC
(FNDC3A), transcript variant GATAGCCCAAAGGCTC GTAATAGcccAGAGATT FU31509
691 92676 481 08093 FNDC3A NM 001079673 1, mRNA GATAGCCCAAAGGCTC |LMN_1724410
Homo sapiens viral DNA polymerase-transactivated CCCTGCCCGAGGTGCTGACCCAATTCGCTGCCA
DNAPTP6, DKF2p564A2416 protein 6 (LOC26010), AAAGAGTGTCAATCAGA
2390 5393 2671 681 25136726 LOC26010 NM 001100422 transcript variant 2, mRNA
Homo sapiens hepatoma- AGGCAAACACAACTCTTG
TAAAGCTGGAATCAGCAACAGCCCTATGGGAAA
HDGF2, CGM 42 derived growth factor, related ACTGCCCTCCCACCCTC
CCAGACAAAGCATTGAC
327 18512 752 1476 472 37262 HDGFRP3 NM 016073 protein 3 (HDGFRP3), mRNA CTACCTGTTCAGTAC 1764617
Homo sapiens solute carrier
AGGAAGGACACACAGTAGCTCTCTGCTTGCTGA
BL0V1 family 35, member E3 TAGATGGTTTCCCAGTG
403 8393 50546426 4462143 SLC35E3 NM 018656 (SLC35E3), mRNA
Homo sapiens cornichon GCACCTTTGCTGCCTGT
GCACAGTTGAGGAGCCAGAGACTTCTTAAATCAT
HSPC163 homolog 4 (Drosophila) CATTGTTGCCTGAAGAA CCTTAGAACCGTGACC (CNIH4), mRNA
21925142 20453643 CNIH4 GGCTGGAGTTGCTCTG
ILMN 1750718
Homo sapiens sterol O- acyltransferase (acyl-
CCACGCTCAGTTTGGAC
SOAT, ACAT1, STAT, ACACT, Coenzyme A cholesterol GAGCATTGGAAGGGGTATCAGAGACCATGTAGT CATTGGAGGAACTTAGT ACAT, RP11-215I232 acyltransferase) 1 (SOAT1), TCAACTTTCCACTCAAA GTCACGCACAAATGGG transcript variant 688113,
7458643 14661429 97964294 SOAT1 NM 003101 mRNA ILMN 1735199
Homo sapiens transcriptional
CTTCCTCATTGCAGGGC
KL04P, FLJ12705, ADA2, adaptor 2 (ADA2 homolog, GACTGGCGCAGGCAAGAGCACTCATCAAGATAG TGGGGGAGTCACTTAAC hADA2 yeast)-lιke (TADA2L), ATGTGAACAAAACCCGG CTGTCTGGGGCTCAGT transcript variant 1 , mRNA
52 89282 84 82271 65 104935 TADA2L NM 001488 ILMN 1664351
Homo sapiens G protein-
GPCR41, PAR1, D15Ertd747e AGGCCCGCACACCGGTACACTCGTGGACACCTA coupled receptor 172A GPCR CACACTCCATAGGAGAT
94236426 1298 8059 1112 56 GPR172A NM 024531 (GPR172A), mRNA
Homo sapiens tripartite motif- CTGGGTTTTCAGTGTCCT
AGTCTCTCTACCCTGGGGAGGAACAGTGGCTTC
RNF92, BIA1 contaιnιng 11 (TRIM11), AGCGGAATGCAAGTAGG TCAGAGCCTGGGGCATA mRNA CAGCCAGCCCGTCTG
111 33095 1608601 130 1518 TRIM11 NM 145214 ILMN 1694325
Homo sapiens upstream
LBP-1B, LBP1A, LBP1B, LBP- CCTTTGCTTTCGTGTGACCACATGTTTTCTGTAC binding protein 1 (LBP-Ia) 1a, DKFZp686L1745
1473 506 18466393 1602 5559 UBP1 CAGTCACTGGGGAAAG
NM 014517 (UBP1), mRNA
GGATGTGGCTGGCTCGT
Homo sapiens hypoxia up- AGGGTCAGGGCTGGCCTTCCTCTGTGCATCACT
DKFZp686N08236, ORP 150 GGGAAACAGCAAAACAC regulated 1 (HYOU1), mRNA CTGCTAGGTTGGGGGCC TAAGCCTGACCTCTCC
29933093 4372351 34464764 HYOU1 NM 006389 ILMN 1735055
Homo sapiens
CCAGAAACTGGCTTAGA glycerophosphate O- GCAGAAAAACGCCTTAGCAGCCTGTGTGAGGCT
DAP-AT, DAPAT, DHAPAT GGAGCTCCAAATATGTG acyltransferase (GNPAT), CGGAGTAGTGGAGAAGA GAATTACCACACTCTG
42675595 5158601 45684344 GNPAT NM 014236 mRNA ILMN 1776164
RNF68, 2010002K04Rιk, Homo sapiens polycomb ATGTGGAAAAGCCGTTAA
GATCACATGACAATGAAGCAGATATGGCTCTCCC RNF3A-2, FLJ43754, group ring finger 1 (PCGF1 ), TATCTGCTCACATCTTAC GCTGGTTCGGCAAGCC MGC10882, NSPC1 mRNA
26082263 3172976 27993512 PCGF1 NM 032673 TCAGCATCAGAAAG ILMN_1747824
pOS + no GFs
Synonyms Probe_Sequence Probe_Sequeπce_l Raw XS pOS + 6 GFs Raw Raw Common Geπbank Description Probe Id
Homo sapiens zinc finger,
GATAGGCCCCTTCCTGAGCCTTGGTGTCCCTGG
FLJ14840, MPFYVE FYVE domain containing 19 AATGAGGAAAGATTCTC
28682263 34980597 3150226 ZFYVE19 NM 001077268 (ZFYVE19), mRNA
Homo sapiens glutathione S- GGGACTTCCCTTGACTG
P28, GSTTLp28, GACTGGCAAGGTTTCCTAGAGCTCTACTTACAGA transferase omega 1 GGTTGTGTTTCTTTTCCT DKFZp686H13163 ACAGCCCTGAGGCCTG (GSTO1), mRNA GCCTCAGCCCAGCTC
5084048 9495 839 6432231 GSTO1 ILMN 1796288
Homo sapiens zinc finger, ZZ-
DKFZP564I052, FLJ10362, TTAGTCTGCACAGTGAGCAAGGGTTCACATGCAT type containing 3 (ZZZ3), DKFZp313N0119 TCTTTTATACTGCTGG
69323096 931 11426 7724976 ZZZ3 NM 015534 mRNA
AAGCCAGAAAGTGGAGT
Homo sapiens epsin 1 CCCTCACGCACCCGCTCACGCACCCTCGGTGAA TCTGTCCGCTGCGAGCC (EPN1), mRNA TCCTTGGTGATGATTTT TGGAGATGGGGAACAG
7601 7812 8121 856 7786681 EPN1 NM 013333 ILMN 1667022
Homo sapiens chromosome 3 open reading frame 17 CATATAAGCCCTGGGTCGGGGGGTAACTGTGGG
DKFZP434F2021 (C3orf17), transcript variant 2, GATCACTGCCTGAGACA
84295593 1355 5143 1014 90173 C3ORF17 NM 001025072 mRNA
Homo sapiens DIP2 disco- interactmg protein 2 homolog TCTGGTTTAGGTGTATGTAGTTGGGCCATGTTAC
KIAA1463, MGC104005 B (Drosophila) (DIP2B), TTGTCCAGAGGAAGAG
6760893 731 6893 6938185 DIP2B NM 173602 mRNA
Homo sapiens transferrin AGCTGTCTTCTTGCCCC
GCTCCTGGTCTTGAGATGTCTTCTCGTTAAGGAG
TFR, TFR1. CD71, TRFR receptor (p90, CD71) (TFRC), GGTCAGTGCCAGCCGTA TAGGGCCTTTTGGAGG mRNA CTATTCACAACACTGC
4705 131 75648896 5537 3394 TFRC NM 003234 ILMN 1685327
Homo sapiens RRN3 RNA
MGC104238, TIFIA, polymerase I transcription CGAAATTCCCCAGAAATTAGTAGTAAGTGGGGTC DKFZp566E104 factor homolog (S cerevisiae) TTTGTGGGTTGGGAAG
71 97383 14924762 9299792 RRN3 NM 018427 (RRN3), mRNA
Homo sapiens chromosome 8 CGCTGATATCTGTCTGG
GCCAGTAATCGTTTTTGTTCAGATAGAGGTGTGG
FLJ10204 open reading frame 32 GTGATAAGCAGTTTGGC AGGTAGAGCCAGCCCC (C8orf32), mRNA GTTCTGTGATTCCAGC
19407262 2652268 21532262 C8ORF32 NM 018024 ILMN 1763313
Homo sapiens interleukin 4
TGTGGGCCGGGCAATCCAGACAGCAGGCATAAG
IL4RA, CD124 receptor (IL4R), transcript GCACCAGTTACCCTGCA
97 80019 196 12679 117 776794 IL4R NM 000418 variant 1 , rnRNA Homo sapiens v-ral simian leukemia viral oncogene
GAGAGAGATAAGCCATCGCCCCTTTGCCTCTGA homolog B (ras related, GTP GAATTGGCTGCTGTTTC binding protein) (RALB),
12794392 20507644 15074976 RALB NM 002881 mRNA
Homo sapiens CD164 GCCCCCGAGAGACATGA
GTTAGATTTTGCAAGTCTACAAATGAGCTCTTGC endolyn, MGC-24, MUC-24 molecule, sιalomucιn (CD164), CTTCCAAGCCGCATTCC AACAGAACTCACAGCC mRNA GACTGGATTCCCTACA
25589761 2987768 268 38928 CD164 NM 006016 ILMN 1779579
Homo sapiens adenosine
GGGACTGCCGGTGGCCATCTTTTCCTACTACCT
HADAT1 deaminase, tRNA-specific 1 AGAGAAAGCCAGCAAAG
31806427 3303601 321 58093 ADAT1 NM 012091 (ADAT1), mRNA
pOS * no GFs
Synonyms Probβ_Sequence_l Raw XS pOS + 6 GFs Raw Raw Common Genbank Description Probβ.Sβquence probβ |d
Homo sapiens ARP3 actin- CTGTCCAGAGGGTTATT
GAAGAGTAAAGACAAGAGTGTTGGACCAGTATT
ARP3 related protein 3 homolog CAGGAGGCTGGTGGTGG GCAGTTCTGTAGTGTCA (yeast) (ACTR3), mRNA CATGATGAGTGTGGAG
26452976 36428062 2951 6475 ACTR3 NM 005721 ILMN 1695193
Homo sapiens SEC14 and
GCGCTGCACTTCTCGGTCATCTGGGGATACACT
DKFZp434O0515, SOLO spectrin domains 1 (SESTD1 ),
237 41428 4495393 29658096 SESTD1 NM 178123 TCCTCGACTGAACAGAG mRNA
Homo sapiens mitochondrial πbosomal protein S36
TGGGGCCCCTCCTGTGCCAAGGGTACGTATATT
MRP-S36, MGC22896, DC47 (MRPS36), nuclear gene GTGAAGTAAAGCCTCAC encoding mitochondrial protein, mRNA
8708992 88 03931 8986612 MRPS36 NM 033281
Homo sapiens zinc finger,
ZNF237, MYM, HSPC050, GGTCATCCAGCTTGTCCTTTAGTCAGTAGATCTA MYM-type 5 (ZMYM5), ZNF198L1 GGAACTCACCAGTGGA
53 36512 6862071 57 733624 ZMYM5 NM 001039649 transcript variant 2, mRNA Homo sapiens Ion peptidase
TAGTCCAGCTACTTGAGGCTGAGATGGGAGGAT
LONP. MGC4840, LONPL 2, peroxisomal (L0NP2),
GAGGGAGGTCGGGGCTG
58 290684 6620669 6096512 mRNA
Homo sapiens transmembrane GGAGACTGATCCTGCCA
SMBP, EP70-P-ISO, RP11- ATCTGTTCAGGTTGGTGTACCGTGTAAAGTGGG
9 superfamily member 3 TCACTGCTGCAAAGCAG 34E5 1 GATGGGGTAAAAGTGGT (TM9SF3), mRNA AACACGAGACTCAAGG
727 0893 864 7726 7632976 TM9SF3 NM_020123 ILMN 1685750
Homo sapiens SAC1 CTCCTATTCCTACATGGT
SAC1. KIAA0851, suppressor of actin mutations TCGTGGGGGCCACTTTG CTGAACTGCTAATGTGGCTGCTTTGTAGGGAATG DKFZp686A0231 1*e (yeast) (SACM1L). CGGCCTTTGAGGAGC GACTAATATCAGTGTG
53220593 73260596 582 0643 SACM1L NM 014016 mRNA ILMN 1701025
Homo sapiens twinfilin, actin-
MGC41876, MGC23788, A6, GCAGACTTCCTTTATGAAGAAGTACATCCCAAGC binding protein, homolog 1 PTK9 AGCATGCACACAAGCA (Drosophila) (TWF1), mRNA
22006429 321 3393 250 1726 TWF1 NM 002822
Homo sapiens SUM01/sentrιn GGAGGGCTGGAATCTGT
ACATGCCCCGAGTGCGGAAGAGGATTTACAAGG
MGC27076, FLJ42398 specific peptidase 5 (SENP5), CTTCCCTGACTCGGCTC AGCTATGTGAGTGCCGG mRNA CTCAGGTCTTTAGCCT
58259773 17037262 83435196 SENP5 NM 152699 ILMN 1711786
Homo sapiens zinc finger, TGTCAGGACGCGGAAAG
GGACAGGATTCGATTAAGTATTCCCTCTTGTCAA
ZNF372 DHHC-type containing 2 CAGGGAGGCAAGGCCC ACTGGAAGCTAGGGGA (ZDHHC2), mRNA GCGCTAAGGCCAAGTCG
49395973 125 39345 67 78848 ZDHHC2 NM 016353 ILMN 1747589
Homo sapiens potassium
CATGGATCATTGTCCTAT channel tetramerisation CAGGCCAAGGGTACTTGGGAGAGCCCCTCATGG GAGAGTGTAAGCTCCTC domain containing 21 AGAACCTAGTTTAGACC AAGCACAGCTCGTGC
3438393 36049762 351 01013 KCTD21 NM 001029859 (KCTD21), mRNA ILMN 1743329
PREDICTED Homo sapiens N
GGTACTGAGTGTCCAGA acetyitransferasθ 1 (arylamine TTGGTTTTGAGACCACGATGTTGGGAGGGTATG
GCTGCCTCCCCAGGAGG N-acetyltransferase) (NAT1), TTTACAGCACTCCAGcc
TTAAGGTGGGGGCAAA mRNA
73 393654 94 78099 790437 NAT1 XM 001127234 ILMN 1679746
Homo sapiens matrix
CAGAAGTATGGCCCAGA metallopeptidase 10
SL-2, STMY2 AGAGCCCTTGCCCCGCC CAGTGGATCATCACAGTTTGAGTTTGACCCCAAT (stromelysiπ 2) (MMP10),
10315353 227 28928 29578827 MMP 10 TGTCTGCCCTTGGTGG GCCAGGATGGTGACAC
NM 002425 mRNA ILMN 1657505

Claims

1. An isolated mammalian cell having the developmental potency of an embryonic stem cell (ESC), the cell being characterised in that the cell does not form a teratoma when provided in an immune deficient animal.
2. The isolated mammalian cell of Claim 1, wherein the cell does not contain, or contains a relatively low amount of one or more of the mRNAs shown in Table 3.
3. The isolated mammalian cell of Claim 1, which does not contain, or contains a relatively low amount of one or more of DNMT3b, HDAC2, Nanog, Sox 2, Oct3/4, SET, ZFP42, HMGB 1 or ARID38 mRNA.
4. The isolated mammalian cell of any one of the preceding claims wherein the cell contains one or more mRNAs shown in Table 1 or Table 2.
5. The isolated mammalian cell of any one of the preceding claims wherein the cell contains one or more of SPl, ANP32A, Myc, HMGAl, SMARCADl, SMARCCl, PTMA, MCM6, PCNA, HDACl, KLF5, KLF4, BTBD14B, HoxA5, FoxAl, Meisl and ENl mRNA.
6. The isolated mammalian cell of any one of the preceding claims wherein the cell has a profile of mRNA expression as shown in Table 4.
7. The isolated mammalian cell of any one of the preceding claims which expresses one or more proteins set forth in Table 6.
8. The isolated mammalian cell of Claim 7, wherein the one or more proteins are expressed by at least 20% of isolated mammalian cells and/or wherein mean fluorescence is greater than 5000 units, and/or greater than 18,000 units..
9. The isolated mammalian cell of Claim 1, which expresses one or more of Oct4, Sox2, NANOG, KLF4, MVH, KIT and Nestin.
10 The isolated mammalian cell of any one of the preceding claims wherein the cell is produced by a process including culturing one or more cells tissues in a medium comprising one or more of FGF9, FGF2, SCF and leukaemia inhibitory factor (LIF), thereby providing the cell.
11. The isolated mammalian cell of Claim 10, wherein the cell is produced by a process including culturing neurospheres or a neurosphere -like cellular mass in a medium comprising one or more of FGF2, FGF9, SCF and/or LIF, thereby providing the cell.
12. The isolated mammalian cell of Claim 10 or Claim 11, which is a human cell, wherein the the medium comprises one or more of FGF2, FGF9, SCF, LIF, TGF-β2 and/or BMP-4.
13. The isolated mammalian cell of Claim 10, 11 or 12, which is produced by a process including:
(a) forming a neurosphere or neurosphere -like cellular mass from a sample of tissue;
(b) obtaining the cell from the neurosphere or neurosphere —like cellular mass, thereby providing the cell.
14. The isolated mammalian cell of any one of Claims 10 to 13, wherein the one or more cells or tissues are of adult origin.
15. The isolated mammalian cell of any one of Claims 13-16, wherein the cell or tissue comprises bone marrow, central nervous system tissue, neural tissue, skin, gut, pancreas, muscle, brain, heart, adipose, olfactory mucosa or other mucosa or epithelia.
16. The isolated mammalian cell of any one of the preceding claims, which is a germline competent cell.
17. The isolated mammalian cell of any one of the preceding claims, which is a pluripotent stem cell.
18. The isolated mammalian cell of any preceding claim which is of human, mouse or rat origin.
19. An isolated mammalian cell selected from the group consisting of:
(i) an isolated human cell designated human X Y pOS- 17 deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121602;
(ii) an isolated mouse cell designated B6 Rosa26-EGFP XY Pos deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121601; and/or
(i) an isolated rat cell designated SD Rat XY pOS deposited at the European Collection of Cell Cultures (ECACC) on December 16 2009 with accession number 09121603.
20. The isolated mammalian cell of any one of the preceding claims, which is genetically modified.
21. The isolated mammalian cell of Claim 21, which is genetically modified to express a therapeutic agent.
22. The isolated mammalian cell of Claim 22, wherein the therapeutic agent is a protein or an RNA molecule.
23. A method for producing an isolated, pluripotent mammalian cell including culturing one or more cells or tissues obtained from a mammal in a medium containing one or more of FGF2, FGF9, SCF and LIF, thereby producing the isolated, pluripotent mammalian cell.
24. The method of Claim 23, wherein the isolated mammalian cell is a human cell, the medium comprises one or more of FGF2, FGF9, SCF, LIF, TGF-β2 and/or BMP-4.
25. The method of Claim 23 or Claim 24 wherein the cell or tissue comprises, or is obtainable from, bone marrow, central nervous system tissue, neural tissue, skin, gut, pancreas, muscle, brain, heart, adipose, olfactory mucosa or other mucosa or epithelia.
26. The method of Claim 25 wherein the cell or tissue is obtainable from olfactory mucosa.
27. The method of Claim 26, including culturing neurospheres or a neurosphere- like cellular mass obtainable from olfactory mucosa.
28. The method of Claim 27, including
(a) forming a neurosphere or neurosphere-like cellular mass;
(b) isolating the pluripotent cell from the neurosphere or neurosphere-like cellular mass,.
29. The method of any one of Claims 23 to 28 wherein the one or more cells or tissues are of adult origin.
30. A composition comprising the isolated mammalian cell of any one of Claims 1-22 and a carrier, diluent or excipient.
31. An isolated mammalian cell according to any one of Claims 1-22 for use in treating a disease or condition in a mammal.
32. An isolated mammalian cell for use according to Claim 31, wherein the disease or condition is selected from the group consisting of: nerve injury, spinal injury, schizophrenia, Parkinson's disease, Alzheimer's disease, bipolar disorder, mitochondrial disorders, epilepsy, diabetes, kidney failure, neuro-degenerative diseases, plastic anemia, immune-deficiency diseases, autoimmune diseases, cancers including lymphomas and leukemias, sickle cell anemia and osteoporosis.
33. An isolated mammalian cell for use according to Claim 31 or Claim 32, wherein the mammal is a human.
34. A method of treatment of a disease or condition in a mammal, said method including the step of administering an isolated mammalian cell according to any one of Claims 1-22, or a cell differentiated therefrom, to said mammal to thereby treat said disease or condition.
35. The method of Claim 34, wherein the isolated mammalian cell is autologous to said mammal.
36. The method of Claim 34 or Claim 35, wherein the disease or condition is selected from the group consisting of: nerve injury, spinal injury, schizophrenia, Parkinson's disease, Alzheimer's disease, bipolar disorder, mitochondrial disorders, epilepsy, diabetes, kidney failure, neuro-degenerative diseases, plastic anemia, immune-deficiency diseases, autoimmune diseases, cancers including lymphomas and leukemias, sickle cell anemia and osteoporosis.
37. The method of any one of Claims 34-36, wherein the mammal is a human.
38. A method of producing a non-human mammal, said method including the steps of:
(i) delivering one or more isolated mammalian cells of the aforementioned aspects to a blastocyst of a non-human mammal; and (ii) producing one or more progeny from said blastocyst.
39. The method of Claim 38, wherein the one or more progeny comprise one or more cells or tissues that have a genetic complement of the one or more isolated mammalian cells delivered at step (i).
40. The method of Claim 39, further including the step of implanting or otherwise transferring the blastocyst produced at step (i) to a female non-human mammal.
41. The method of any one of Claims 38-40, wherein the one or more isolated mammalian cells delivered at step (i) are genetically modified, whereby the progeny produced at step (ii) are genetically modified.
42. The method of any one of Claims 38-41, wherein the non-human mammal is a mouse or rat.
43. A method of identifying, designing, screening or otherwise producing a compound having a desired activity, said method including the step of contacting a candidate compound with an isolated mammalian cell of any one of Claims 1-22, or a cell differentiated therefrom, to thereby determine whether said compound has said activity.
44. A method of identifying, designing, screening or otherwise producing a compound having a desired activity, said method including the step of administering a candidate compound to a non-human mammal produced according to the method of any one of Claims 38-42, to thereby produce a compound having said activity.
45. The method of Claim 43 or Claim 44, wherein the activity includes include cell growth and/or differentiation, anti-tumour activity, pro- or anti-apoptotic activity, neuropharmacological activity; regulation of metabolism; hormonal activity; gene regulatory activity; cell cycle regulation and immunoregulatory activity.
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