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Detection of Telomere Transfer at Immunological Synapse

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The Immune Synapse

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2654))

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Abstract

Eukaryotes solve the DNA-end replication problem synthesizing hexameric chromosome ends known as telomeres. Recent studies have uncovered unexpected functions of telomeres in linking synaptic signaling and vesicle transport, with at least one pathway directly involved in transferring telomeres through the immune synapse. These emerging forms of cellular communication may originate a new class of antiaging interventions based on telomere transplants.

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Acknowledgments

A.L. designed and conceived chapter and wrote C. D. A. wrote the protocol under guidance of A.L.

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Authors and Affiliations

  1. Sentcell UK laboratories, Rome, Italy

    Alessio Lanna & Clara D’Ambra

Authors
  1. Alessio Lanna
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  2. Clara D’Ambra
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Corresponding author

Correspondence to Alessio Lanna .

Editor information

Editors and Affiliations

  1. Department of Life Sciences, University of Siena, Siena, Italy

    Cosima T. Baldari

  2. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

    Michael L. Dustin

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Lanna, A., D’Ambra, C. (2023). Detection of Telomere Transfer at Immunological Synapse. In: Baldari, C.T., Dustin, M.L. (eds) The Immune Synapse. Methods in Molecular Biology, vol 2654. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3135-5_16

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  • DOI: https://doi.org/10.1007/978-1-0716-3135-5_16

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3134-8

  • Online ISBN: 978-1-0716-3135-5

  • eBook Packages: Springer Protocols

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