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Total Synthesis and Chemical Modification of the Aminoglycoside Antibiotics

  • Chapter
Aminoglycoside Antibiotics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 62))

Abstract

The number of structurally elucidated aminoglycoside antibiotics of microbial origin is now about one hundred. Various aminoglycoside antibiotics have been introduced into, and have become established in, chemotherapy. The study of this group of antibiotics has provided some fascinating and challenging problems in the field of carbohydrate chemistry. After several decades of work on the determination of chemical structures of naturally occurring aminoglycoside antibiotics, it was inevitable that organic chemists would turn their attention toward total synthesis; however, the synthetic chemistry of this important group of antibiotics was rather slow in developing until the end of the 1960s.

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Authors
  1. S. Umezawa
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  2. T. Tsuchiya
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Editors and Affiliations

  1. Institute of Microbial Chemistry, 14-23 Kamiosaki 3-Chome, Shinagawa-ku, Tokyo, Japan

    Hamao Umezawa

  2. Research Associate, Duke University Marine Laboratory, Pivers Island, 28516, Beaufort, NY, USA

    Irving R. Hooper

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Umezawa, S., Tsuchiya, T. (1982). Total Synthesis and Chemical Modification of the Aminoglycoside Antibiotics. In: Umezawa, H., Hooper, I.R. (eds) Aminoglycoside Antibiotics. Handbook of Experimental Pharmacology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68579-8_2

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