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Structural Alterations in Non-enveloped Viruses During Disassembly

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Physical Virology

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 24))

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Abstract

The capsid shells of non-enveloped viruses can be categorized as large macromolecules constituted from protein building blocks, with the primary purpose of protecting and delivering the viral genome inside living cells during an infection. Non-enveloped virus capsids incorporate stability as well as dynamicity, which allows them to survive inhospitable conditions in the environment, and disassemble within host cells to ensure transfer of the genome for downstream replication and translation. In this chapter, we discuss the metastability of the non-enveloped capsids, ensured by molecular switches, that allow the highly stable assemblies to be destabilized under mild but specific physiological conditions. The structural alterations induced in non-enveloped capsids as well as in nucleocapsids of enveloped viruses during disassembly of the capsid shell, culminating in the release of genome, is extensively discussed. Disassembly is a key step in the establishment of infection and any spatiotemporal alteration in this step may diminish infectivity. Thus, a detailed understanding of the molecular pathways of disassembly may result in the development of more effective intervention methods and antiviral compounds.

Kimi Azad and Debajit Dey—Equal contribution.

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  1. Institut Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France

    Kimi Azad

  2. School of Medicine, University of Maryland, Rockville, MD, USA

    Debajit Dey

  3. Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, 110016, India

    Manidipa Banerjee

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  1. Autonomous University of San Luis Potosi, San Luis Potosí, Mexico

    Mauricio Comas-Garcia

  2. Autonomous University of San Luis Potosi, San Luis Potosí, Mexico

    Sergio Rosales-Mendoza

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Azad, K., Dey, D., Banerjee, M. (2023). Structural Alterations in Non-enveloped Viruses During Disassembly. In: Comas-Garcia, M., Rosales-Mendoza, S. (eds) Physical Virology. Springer Series in Biophysics, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-031-36815-8_9

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