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Functional In Vivo Imaging of Tumors

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Tumor Microenvironment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 180))

Abstract

Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the in vivo analysis of the mechanisms such as gene expression, signal transduction, biochemical reactions, regulatory pathways, cell trafficking, and drug action underlying cancer noninvasively. The main focus of imaging in cancer is the development of new contrast methods/molecular probes for the early diagnosis and the precise evaluation of therapy response. In clinical setup, imaging modalities facilitate screening, prediction, staging, biopsy and therapy guidance, therapy response, therapy planning, and prognosis of cancer. In this book chapter, we review different established and emerging in vivo imaging modalities and their applications in monitoring functional, molecular, and metabolic changes in cancer.

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Authors and Affiliations

  1. Functional and Molecular Imaging, Sidra Medicine, Doha, Qatar

    Mohammad Haris, Sabah Nisar, Sheema Hashem, Ajaz A. Bhat & Santosh Yadav

  2. Laboratory Animal Research Center, Qatar University, Doha, Qatar

    Mohammad Haris, Muralitharan Shanmugakonar & Hamda Al-Naemi

  3. Center for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Mohammad Haris, Puneet Bagga & Ravinder Reddy

  4. Academic Health System, Translational Research Institute, Hamad Medical Corporation, Doha, Qatar

    Shahab Uddin

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  1. Mohammad Haris
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  2. Sabah Nisar
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  3. Sheema Hashem
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  4. Ajaz A. Bhat
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  6. Muralitharan Shanmugakonar
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Correspondence to Mohammad Haris .

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Editors and Affiliations

  1. Department of Immuno-Oncology, City of Hope National Medical Center, Duarte, CA, USA

    Peter P. Lee

  2. Refuge Biotechnologies, Menlo Park, CA, USA

    Francesco M. Marincola

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Haris, M. et al. (2020). Functional In Vivo Imaging of Tumors. In: Lee, P., Marincola, F. (eds) Tumor Microenvironment. Cancer Treatment and Research, vol 180. Springer, Cham. https://doi.org/10.1007/978-3-030-38862-1_1

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  • DOI: https://doi.org/10.1007/978-3-030-38862-1_1

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