Human Gene SCYL3 (ENST00000367771.11) from GENCODE V44
Description: Homo sapiens SCY1 like pseudokinase 3 (SCYL3), transcript variant 1, mRNA. (from RefSeq NM_020423) RefSeq Summary (NM_020423): This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]. Gencode Transcript: ENST00000367771.11 Gencode Gene: ENSG00000000457.14 Transcript (Including UTRs) Position: hg38 chr1:169,849,631-169,893,896 Size: 44,266 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr1:169,853,713-169,888,840 Size: 35,128 Coding Exon Count: 12
ID:PACE1_HUMAN DESCRIPTION: RecName: Full=Protein-associating with the carboxyl-terminal domain of ezrin; AltName: Full=Ezrin-binding protein PACE-1; AltName: Full=SCY1-like protein 3; FUNCTION: May play a role in regulating cell adhesion/migration complexes in migrating cells. SUBUNIT: Interacts with EZR/VIL2 C-terminal domain. INTERACTION: P15311:EZR; NbExp=4; IntAct=EBI-1380680, EBI-1056902; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia. TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The protein kinase domain is predicted to be catalytically inactive. PTM: May be myristoylated; myristoylation may target it to Golgi compartment. PTM: Phosphorylated. SIMILARITY: Belongs to the protein kinase superfamily. SIMILARITY: Contains 4 HEAT repeats. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IZE3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
