KR20070099564A - Methods for assessing patients with acute myeloid leukemia - Google Patents

Abstract

Methods for treating cancer, and preferably hematological malignancy, patients include analyzing gene expression profiles and/or molecular markers of a patient to determine status and/or prognosis of the patient. The invention also provides methods of analyzing whether a non-relapsed or non-refractory patient is likely to respond to treatment with farnesyl transferase inhibitors (FTIs) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes modulated in response to FTI treatment are provided and are used in formulating the profiles.

Description

How to assess patients with acute myeloid leukemia {Methods for assessing patients with acute myeloid leukemia}

The attached "Sequence List" is hereby incorporated by reference.

The present invention relates to the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) based on the detection of molecular markers and / or gene expression analysis.

Karyotyping is currently effective in providing prognostic values and also identifies biologically clear subtypes of AML. In addition, intragenic mutations such as FLT3, c-KIT, AML1, GATA1, CEBPA and N-RAS are associated with the pathogenesis of the disease. It is clear that screening for FLT3 and CEBPA mutations can stratify groups with different recurrence risks. Effective risk stratification may allow for the proper use of allogeneic stem cell transplants or other adjuvant therapy. Two published publications have recently described their use in gene expression profiling and clinical outcomes in newly diagnosed adult AML patients. Bullinger et al. (2004); and Valk et al. (2004)]. These studies indicate that gene-expression profiling can also further quantify clinical outcome predictions.

Valk et al. (2004) evaluated 285 patients (bone marrow or peripheral blood) on an Affymetrix U133A chip. Patient samples contained a wide range of cytogenetic and molecular abnormalities. Only 16 clusters have been identified, indicating that AML may not be heterogeneous as previously considered. Several clusters corresponded well to the cytogenetic and molecularly defined subtypes of AML and thus support their use in the WHO classification system. These clusters are also described in Bullinger et al. (2004)] and in other lesser published studies. Schoch et al. (2002); Debernardi et al. (2003); And Kohlmann et al. (2003). Since these clusters are associated with well-known diagnostic karyotypes, it is not surprising that they are associated with prognosis.

Bullinger et al. (2004) examined expression profiles from 116 adult patients (65 peripheral blood and 54 bone marrow) using cDNA arrays. In addition to the work performed by Volk et al. (2004), they also developed 133 gene classifiers for clinical outcomes predicted across all cytogenetic risk groups. Using a training set of 59 samples and a test set of 57 samples, they showed that 133 genes grouped patients into poor and good outcome groups (p = 0.006 log level; extra ratio, 10, 95%). CI, 2.6-29.3).

Surprisingly, only some of the genes identified in both of these studies overlap with predictor genes already identified in pediatric leukemia (Yagi et al. (2003)). In addition, there is no overlap between the prognostic gene set identified by Bullinger et al. (2004) and the three recently identified genes predicting response to Tipifarnib (see US Patent Application No. 10 / 883,436).

Farnesyl transferase (FTase) enzymes mediate covalent attachment of carbon farnesyl residues to C-terminal CAAX (C, cysteine; A, aliphatic residues; X, any amino acid) cognitive motifs. Reiss et al. (1990)]. This farnesylation is also further processed by cleavage of the 3-terminal amino acid (AAX) and methylation of the C-terminal isoprenyl-cysteine. Inhibition of protein farnesylation interferes with the exact blast localization required for protein action. Originally, oncogenic Ras protein was thought to be a target for the anti-proliferative effect of FTI in cancer biology. Reuter et al. (2000)]. However, it has been found that the inhibition of Ras farnesylation does not contribute to all the action of Tipifarnib. For example, FTI does not always require the presence of the mutant Ras protein to produce an antitumor effect. Karp et al. (2001). Furthermore, even if early clinical studies were designed in populations with high incidences of ras mutations such as colorectal and pancreatic cancers, no significant difference in response rate was observed compared to placebo. Van Cutsem et al. (2004); And Rao et al. (2004)].

Several other farnesylated proteins mediate the anti-tumorogenic effects of FTI, including the small GTPase proteins Rho B, the conformer proteins CENP-E and CENP-F, the protein tyrosine phosphatase PTP-CAAX, and nuclear membrane structures Lamine A and B. It is suggested as possible candidate target. Inhibition of farnesylation of these proteins can result in the antiproliferative effect of FTI and indirectly induces several important signaling molecules including TGFβRII, MAPK / ERK, PI3K / AKT2, Fas (CD95), NF-kB, and VEGF. Adnane et al. (2000); Morgan et al. (2001); Jiang et al. (2000); Na et al. (2004); Takada et al. (2004); And Zhang et al. (2002)]. Regulation of this signaling pathway mediates cell growth, proliferation and apoptosis. That is, FTI can have complex inhibitory effects on several cellular events and pathways.

At present, there is no method for measuring the condition of these patients or for predicting overall survival.

Brief summary of the invention

The present invention is a method of using one or more genetic signatures to predict prognosis in acute myeloid leukemia (AML) patients. These signals may be used alone or in combination depending on the type of drug treatment.

The present invention obtains a biological sample from a patient with acute myeloid leukemia (AML); Provided are methods for assessing AML status by measuring biomarkers associated with marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8, or Table 9, wherein the measurements have already been made. Expression levels of marker genes above or below the cut-off level indicated are indicative of AML status.

The present invention obtains a biological sample from a patient with acute myeloid leukemia (AML); Provided are methods for staging AML patients by measuring biomarkers associated with marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9. Expression levels of marker genes above or below the measured cut-off level are indicative of AML survival.

The present invention obtains a biological sample from a patient with chronic myeloid leukemia (AML); Provided are methods for determining treatment protocols for AML patients by measuring biomarkers associated with marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9. The level of expression of marker genes above or below the cut-off level is determined by the response of the therapy to the clinician so as to determine the extent and type of the recommended therapy to provide the appropriate therapy. It is a good indicator.

The present invention obtains a biological sample from a patient with chronic myeloid leukemia (AML); Measuring a biomarker associated with a marker gene corresponding to a marker gene selected from Table 3, Table 4, Table 5, Table 7, Table 8, or Table 9, wherein at least a cut-off level previously measured or Expression levels of the marker genes below are indicative of response to therapy); Provided are methods for treating AML patients by treating the patient with adjuvant therapy if the patient has a responder profile.

The present invention obtains a biological sample from a patient with chronic myeloid leukemia (AML); Provided are methods for determining whether the risk of death in acute myeloid leukemia (AML) patients is high or low by measuring biomarkers associated with marker genes corresponding to the marker genes selected from Table 3, wherein the cuts already measured Expression levels of marker genes above or below the level are sufficient indicators of mortality risk that allow the clinician to determine the extent and type of recommended therapy.

The present invention measures the results of any of the methods described above; A method for generating an acute myeloid leukemia (AML) prognosis patient report is provided by preparing a report representing the results and the reports generated thereby.

The present invention provides an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, its complements or portions thereof. Provided are kits for performing assays for measuring acute myeloid leukemia (AML) prognosis in a biological sample, comprising a substance for detection.

The present invention detects an isolated nucleic acid sequence of a gene selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, their complements or portions thereof. Provided are products for assessing acute myeloid leukemia (AML) status, including the following materials.

The present invention provides a microarray or gene chip for carrying out the method described above.

The present invention provides an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, its complements or portions thereof. Provide a diagnostic / prognostic portfolio that includes

1 shows unsupervised clusters of relapsed and refractory AML patients. The dendogram represents an unsupervised k-means cluster of 58 relapsed or refractory AML patients, where each column represents a patient and each row represents a gene. The expression rate for each gene was calculated by dividing the expression level of the gene in the patient by the mean of all other patients. The colored bars represent the fold change (log2). Red indicates unregulated, blue indicates down-regulated. White indicates no change. The presence of six major clusters is shown.

2 shows real-time RT-PCR of two genes. AHR and AKAP13 were measured by real time RT-PCR. Gene expression values were normalized using HPRT or PBGD control genes. Error bars are standard deviations. The values obtained were plotted against the corresponding microarray data and linear regression analysis was performed.

3 shows the predicted value of the AKAP13 gene. Panel A shows a 2 × 2 table generated from LOOCV performed using AKAP13 expression as classifier on responder (R) and non-responder (NR). Panel B shows AKAP13 expression values for the same 58 patients. P values represent significant differences in gene expression between the mean values of each response group. Panel C shows Kaplan-Meier curves generated from patients classified by the AKAP13 gene as responders and non-responders.

4 provides identification of the minimum set of predictive markers. In panel A, LOOCV was performed using 100% sensitivity. Independent classifiers containing 1 to 19 genes were tested. Plot the error rate obtained. Panel B shows a 2 × 2 table generated from LOOCV performed using 3-gene signals as classifiers in responders (R) and non-responders (NR). Panel C shows the scores generated from the 3-gene classifiers. P values show a significant difference in gene expression between reaction groups. Panel D is a Kaplan-Meier curve generated from patients classified by 3-gene signals as responders and non-responders. Mean survival time is also shown.

FIG. 5 depicts Kaplan-Meier analysis performed in patients classified as 3-gene signals as predicted responders and non-responders. Survival curves of patients defined clinically as non-responders but classified as responders when using 3-gene signals are shown. Mean survival time is also shown.

6 shows over-expression of AKAP13 in AML cell lines. Cell counts were normalized to the drug free culture (expressed in -12 log units) to obtain% of control. Error bars represent standard error of the mean. White data points represent the results from the second test investigating higher concentrations of drug.

7 provides a model of FTI action in relapsed or refractory AML. IL3RA and AKAP13 genes in the responder are lowly expressed to allow down-regulation of ras and RhoA and Lamin B pathways, respectively. Up-regulation of RhoH increases the inhibition of cellular transformation pathways. Along with this allows greater efficacy in FTI anti-tumorogenicity. B. Contrary expression profiles are observed in non-responders that allow expression of the complement pathway.

8 relates to the Zarnestra predictive gene signal with greater utility than the independent prognostic gene signal. In panel A the columns represent AML samples from relapsed or refractory patients and the rows correspond to 167 corresponding to 103 of 133 prognostic genes identified by Bullinger et al. Ordered according to hierarchical clustering. Represents a probe set. Panel B shows Kaplan-Meier survival assessment of cluster-defined groups of patients. In Panel C, a 3-gene classifier was used to identify responders of Tipifarnib in the good and poor prognosis groups defined by the Bullinger signal. Kaplan-Meyer survival curves represent patients identified as being responders to tipiparnib in the good (Zn + cluster 1) and poor (Zn + cluster 2) prognostic groups. The median survival time for each group is also shown.

FIG. 9 is a flow chart depicting how genes from Bullinger et al. (2004) match for 167 probe sets (103 unique genes) in an Affymetrix U133A chip.

10 illustrates the use of 167 probe set signals in relapsed or refractory AML patients. In panel A, columns represent AML samples from relapsed or refractory patients and rows correspond to 167 probes corresponding to 103 of 133 prognostic genes identified by Bullinger et al. (2004), arranged according to systematic clustering. Represents a set. Panel B shows Kaplan-Meier survival assessment of cluster-defined groups of patients.

Figure 11 compares prognosis and Zarnestra predictive gene signals. Panel A shows Kaplan-Meier survival curves for the good and poor diagnostic clusters defined for a subset of the genes of 103 Bullinger et al. (2004). Panel B shows Kaplan-Meyer survival curves for good and poor diagnostic clusters as defined by the 3-gene signal predicting the response to Zarnestra. Panel C shows Kaplan-Meier survival curves for good and poor prognosis clusters from Panel A, further stratified by 3-gene Jarnestra signal. Panel D shows Kaplan-Meier survival curves for patients vs. the rest of patients predicted to have poor prognosis and not respond to Zarnestra.

12 shows confirmation of the minimum set of prediction markers. a) LOOCV was performed to select genes with 100% sensitivity, 40% specificity and> 2 fold changes. Separate classifiers containing 1 to 8 genes graded by AUC were tested. Plot the error rate obtained. b) A 2 × 2 table generated from LOOCV was performed using AKAP13 as a classifier for responders (R) and non-responders (NR). c) gene-expression value of AKAP13. P values indicate significant differences between gene expression between response groups. d) Kaplan-Meier curves were generated from patients classified by AKAP13 as responders and non-responders. Median survival time is also shown.

13 shows an overview of gene expression analysis.

FIG. 14 shows an AML sample that retains FTI-mediated total gene expression changes after termination of Tipifarnib treatment.

15 shows testing of predictive expression profiles and predictive classifiers in newly diagnosed AML.

16 shows the 6-gene classifier stratifying newly diagnosed AML.

The subset of genes described above as having diagnostic values in newly diagnosed AML has been found to be useful herein in relapsed and refractory AML patients treated with molecularly targeted therapy (Zarnestra). At present, there is no method for predicting the response to farnesyl transferase inhibitors (eg Zarnestra). In addition, current methods for understanding the prognosis of AML patients are limited to histological subtypes and karyotyping, both of which are not ideal markers for measuring clinical outcome. Current signals extend this traditional technique by providing better stratification of prognostic high risk and low risk patients.

United States Patent Application No. 10/883 436 discloses a 3-gene classifier (AHR, and MINA53 include AKAP13) a Parr nibeu typhimurium, the refractory AML patients for recurrence (jareune stripe ^® (Zarnestra ^®) containing R115777) with the lowest error rate Demonstrates predicting response. This was also observed when performing leave-five-out cross validation. When more genes are added, the error rate is increased, indicating that additional genes introduce noise into the classifier. For the 3-gene classifier, LOOCV demonstrated 86% sensitivity and 70% specificity with 74% total diagnostic accuracy. Kaplan-Meyer analysis again showed a significant difference in survival between the predicted and non-responder groups. In addition, when incorrectly classified non-responders were compared with correctly classified non-responders, misclassified non-responders showed better total survival.

Zarnestra® is an orally useful non-peptidomimetic competitive farnesyl transferase inhibitor (FTI) that has been found to inhibit the growth of various human tumor cell lines both in vitro and in vivo. End et al. (2001); And Cox et al. (2002)]. Phase I clinical trial of Tipifarnib demonstrated a 32% response rate in patients with relapsed or refractory acute myeloid leukemia. Karp et al. (2001). Activity is also seen in myelodysplastic syndromes (MDS) [Kurzrock et al. (2004)], multiple myeloma (MM) [Alsina et (2003)] and chronic myeloid leukemia (CML): Cortes et al. (2003) for early clinical trials. Complete relief was defined as less than 5% myeloid blasts with no more than 1000 / μl of neutrophils, less than 100,000 / μl of platelet count, and no extramedullary disease. Although it is evident that FTI acts by inhibiting protein farnesylation, it is still unknown which genes are associated with the antitumor effect of Tipifarnib in hematopoietic malignancies. Microarray technology represents a powerful tool for identifying genes and gene pathways associated with FTI action by allowing simultaneous determination of steady-state mRNA levels of thousands of genes. Thus, overall gene expression monitoring was used in Phase 2 clinical studies of Tipifarnib in relapsed and refractory AML to identify genes predicting response to this FTI in hematologic malignancies.

The simple presence of a nucleic acid sequence with the potential to express a protein or peptide in the genome ("gene") is not a determinant of whether the protein or peptide is expressed in a given cell. Whether the protein or peptide can be expressed or the RNA can be transcribed, and how much such expression or transcription occurs, is, in turn, determined by various complex factors. Nevertheless, assays of gene expression can provide useful information about cellular responses to provided stimuli, such as the introduction of drugs or other therapeutic agents. Relative predictions of the extent to which a gene is active or inactive can be found in this gene expression profile. In some instances, the presence of molecular markers provides useful information about therapeutic efficacy, either by itself or by use of genetic information. Gene expression profiles and molecular markers of the invention can be used to identify and treat AML patients.

Cancers, including hematologic malignancies, usually result from various intragenic mutations. The same type of cancer may occur as a result of or at the same time as one or more mutations that are different from those of other patients with the same type of cancer. Often, the fact that there are multiple molecular criteria in the same cancer is consistent with the observation that some therapies affecting one patient do not necessarily equally affect other patients with the same type of cancer. In addition, from a diagnostic point of view, the presence of specific mutations such as translocations, deletions or SNPs can have strong implications. In some instances, such molecular markers are themselves useful indicators for determining a diagnostic, prognostic or therapeutic response. This is especially true if molecular mutations can be associated with a response to a particular treatment.

Biomarkers are indicative of the expression level of the indicated marker genes. Such indicators can measure direct or under-expression of a gene compared to internal controls, normal tissues or other carcinomas and taking into account physiological parameters and can be direct or indirect. Biomarkers include, but are not limited to, nucleic acids (including overexpression and low expression, and both direct and indirect). The use of nucleic acids as biomarkers may include DNA amplification, RNA, micro RNA, loss of heterozygosity (LOH), single nucleotide polymorphism [SNP; See Brookes (1999), microcesatellite DNA, DNA low- or over-methylation, and may include any method known in the art, including but not limited to. The use of proteins as biomarkers includes, but is not limited to, measuring modifications, activities, and amounts such as immunohistochemistry (IHC), such as glycosylation, phosphorylation, ADP-ribosylation, ubiquitination, etc. Any method known in the art can be included. Other biomarkers include imaging, cell counts and apoptosis markers.

The indicated genes provided herein are those associated with a particular tumor or tissue type. Marker genes may be associated with multiple cancer types, provided that the expression of the gene is specific for lung cancer cells and is sufficiently associated with one tumor or tissue type to be identified using the algorithm described herein. Genes can be used in the claimed invention to measure cancer status and prognosis. Many genes associated with one or more cancers are known in the art. The present invention provides preferred marker genes and even more preferred marker gene combinations. These are described in detail herein.

The marker gene corresponds to this sequence if it contains a sequence designated by SEQ ID NO. A sequence segment or fragment corresponds to the sequence of such a gene if it contains part of the reference sequence or its complement sufficient to distinguish it as a sequence of the gene. A gene expression product corresponds to such a sequence when its RNA, mRNA or cDNA hybridizes to a composition having such a sequence (eg a probe) or, in the case of a peptide or protein, it is encoded by such mRNA. A segment or fragment of a gene expression product corresponds to the sequence of such gene or gene expression product when it contains some or a complement of a referenced gene expression product sufficient to distinguish it as the sequence of such gene or gene expression product.

The methods, compositions, products and kits of the invention described and claimed herein comprise one or more marker genes. A "marker" or "marker gene" refers throughout the specification to genes and gene expression products whose overexpression or underexpression corresponds to a particular gene associated with a tumor or tissue type. Preferred marker genes are described in more detail in Table 8.

The present invention obtains a biological sample from an AML patient; Provided are methods for assessing acute myeloid leukemia (AML) status by measuring biomarkers associated with marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9. The expression levels of marker genes above or below the cut-off already measured are indicative of AML status.

The present invention obtains a biological sample from an AML patient; Provided are methods for timing acute myeloid leukemia (AML) patients by measuring biomarkers associated with marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9. The expression levels of marker genes above or below the cut-off level already measured are indicative of AML survival.

The present invention obtains a biological sample from an AML patient; Provided are methods for measuring acute myeloid leukemia (AML) patients by measuring biomarkers associated with marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9. The expression levels of marker genes above or below the cut-off level already measured are sufficient indicators of response to therapy that allow the clinician to determine the extent and type of recommended therapy to provide the appropriate therapy.

The present invention obtains a biological sample from an AML patient; Measuring biomarkers associated with marker genes corresponding to those selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, wherein above or below cut-off levels already measured Expression levels of the following marker genes are indicative of response to therapy); And a method for treating acute myeloid leukemia (AML) patients by treating the patient with adjuvant therapy if the patient has a responder profile.

The present invention obtains a biological sample from an AML patient; Provided are methods for determining whether the risk of death in acute myeloid leukemia (AML) patients is high or low by measuring biomarkers associated with marker genes corresponding to the marker genes selected from Table 3, wherein the cuts already measured The level of marker genes above or below the level is sufficient indicator of the risk of mortality so that the clinician can determine the extent and type of recommended therapy.

The methods provided herein can comprise, contain, or utilize measuring the expression level of one or more genes constitutively expressed in a sample. Preferably, the methods provided herein result in at least about 40% specificity. Preferably, the methods provided herein produce a sensitivity of at least about 80%. Preferably, the method provided herein produces a p-value of less than 0.05.

The methods provided herein can be performed by measuring gene expression in a microarray or gene chip. The microarray may be a cDNA array or an oligonucleotide array and may also contain one or more internal control reagents.

The methods provided herein can be performed by measuring gene expression by nucleic acid amplification performed by polymerase chain reaction (PCR) of RNA extracted from a sample. PCR may be reverse transcription polymerase chain reaction (RT-PCR) and may also contain one or more internal control reagents.

The methods provided herein can be performed by measuring or detecting a protein encoded by a gene. Proteins can be detected with antibodies specific for the protein.

The methods provided herein can be performed by measuring the properties of genes. Properties include, but are not limited to, DNA amplification, methylation, mutations, and allelic variations.

The present invention measures the results of any of the methods described above; A method for generating an acute myeloid leukemia (AML) prognosis patient report is provided by preparing a report representing the results and the report generated thereby. The report may contain an assessment of the likelihood or response to patient clusters and / or the likelihood or response to chemotherapy.

The present invention provides an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, its complements or portions thereof. Provided are kits for performing assays for measuring acute myeloid leukemia (AML) prognosis in a biological sample, comprising a substance for detection. The kit also contains a reagent for performing microarray analysis and / or a medium in which the nucleic acid sequence, its complement, or part thereof is assayed.

The present invention provides isolated nucleic acid sequences of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, their complements or portions thereof A product for assessing acute myeloid leukemia (AML) status containing a substance for detecting is provided. The product may also contain reagents for performing the medium and / or microarray analysis in which the nucleic acid sequence, its complement, or a portion thereof is assayed.

The present invention provides a microarray or gene chip for performing the above-described method. The microarray may contain an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Tables 3, 4, 5, 7, 8 or 9, complements thereof or portions thereof. . Preferably, the microarray provides a measure or characteristic of 1.5-fold over or low expression. Preferably, the microarray provides a measurement with statistically significant p-value overexpression or underexpression. More preferably, the p-value is less than 0.05. Microarrays can be any known in the art, including but not limited to cDNA arrays or oligonucleotide arrays, and can also contain internal control reagents.

The present invention provides an isolation of a combination of genes selected from the group consisting of marker genes corresponding to those selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9. A diagnostic / prognostic portfolio comprising the prepared nucleic acid sequences, their complements, or portions thereof. Preferably, the measurement or characterization is at least 1.5 times over- or low expression. Preferably, the measurement provides statistically significant p-value over- or low expression. More preferably, the p-value is less than 0.05.

Preferred methods for establishing gene expression profiles include measuring the amount of RNA produced by a gene capable of encoding a protein or peptide. This is accomplished with reverse transcription PCR (RT-PCR), competitive RT-PCR, real time RT-PCR, differential display RT-PCR, Northern blot analysis and other related tests. Although it is possible to perform this technique using individual PCR reactions, it is best to amplify and analyze complementary DNA (cDNA) or complementary RNA (cRNA) produced from mRNA via microarray. Many different array structures and methods of making them are known to those skilled in the art and described in US Pat. Nos. 5,445,934; 5,532,128; 5,532,128; 5,556,752; 5,556,752; 5,242,974; 5,242,974; 5,384,261; 5,384,261; 5,405,783; 5,405,783; 5,412,087; 5,412,087; No. 5,424,186; 5,429,807; 5,429,807; 5,436,327; 5,436,327; 5,472,672; 5,472,672; 5,527,681; 5,529,756; 5,529,756; 5,545,531; 5,545,531; 5,554,501; 5,554,501; 5,561,071; 5,561,071; 5,571,639; No. 5,593,839; 5,599,695; 5,599,695; 5,624,711; 5,624,711; 5,658,734; 5,658,734; And 5,700,637.

Microarray technology represents a powerful tool for identifying effects such as initiating, stopping, or regulating unregulated cell proliferation by allowing simultaneous measurement of steady-state mRNA levels of thousands of genes. Two microarray technologies are currently in wide use. The first is a cDNA array and the second is an oligonucleotide array. Although there are differences in the structure of these chips, essentially all underlying data analysis and results are identical. The products of these assays are a measure of the strength of the signal recovered from labeled probes used to detect cDNA sequences from samples that hybridize to nucleic acid sequences at known positions in the microarray. Typically, the intensity of the signal is proportional to the amount of cDNA and thus proportional to the mRNA expressed in the sample cell. Many such techniques are available and useful. Preferred methods for measuring gene expression are described in US Pat. No. 6,271,002; No. 6,218,122; No. 6,218,114; And 6,004,755.

Analysis of expression levels is performed by comparing these signal intensities. This is best done by generating a ratio matrix of the expression intensity of the gene in the test sample relative to the gene expression intensity in the control sample. For example, gene expression intensity from diseased tissue can be compared with expression intensity generated from malignant or normal tissue of the same type. The ratio of these expression intensities represents a fold change in gene expression between test and control samples.

Gene expression profiles can also be represented in a number of ways. The most common method is to arrange raw fluorescent intensities or non-matrixes in graphical dendograms, where columns represent test samples and rows represent genes. The data is arranged such that genes with similar expression profiles are close to each other. The expression ratio for each gene is visualized by color. For example, a ratio less than 1 (down-regulation) may appear in the blue portion of the spectrum, while a ratio greater than 1 (up-regulation) may appear in color in the red portion of the spectrum. Commercially available computer software programs including "GENESPRING" from Silicon Genetics, Inc. and "DISCOVERY" and "INFER" software from Partek, Inc. This is useful for representing this data.

In determining protein expression by measuring protein levels, any method known in the art is suitable as long as it produces the appropriate specificity and sensitivity. For example, protein levels can be measured by binding to an antibody or antibody fragment specific for the protein and measuring the amount of antibody-bound protein. Antibodies can be labeled with radioactive, fluorescent or other detectable reagents to facilitate detection. Detection methods include, but are not limited to, enzyme-linked immunosorbent assay (ELISA) and immunoblot techniques.

Controlled markers used in the methods of the invention are described in the Examples. Differentially expressed genes are upregulated or downregulated in patients with various lung cancer prognosis. Upregulation and downregulation are relative terms meaning that detectable differences (in excess of the distribution of noise in the system used to measure them) are found in the amount of gene expression relative to some baseline. In this case, the baseline is measured based on the algorithm. Thereafter, the target gene in the diseased cell is up- or down-regulated relative to the baseline level using the same measurement method.

Assays for gene expression status of cells can also measure normal / abnormal tissue distribution for diagnostic purposes using techniques such as immunohistochemical analysis (IHC). Any method known in the art can be used, for example in the case of LBC oncogenes, and freeze-dried and formalin-fixed, paraffin-embedded tissue prepared for the study by IHC for antibodies to LBC proteins. Can be used with both blocks. Each tissue block may consist of 50 mg of residual "pulverized" tumor.

In summary, frozen-fragments rehydrate 50ng of frozen ground tumors at room temperature in phosphate buffered saline (PBS) in small plastic capsules; Pellet the particles by centrifugation; They are resuspended in viscous embedding medium (OCT); Invert the capsule and repellet by centrifugation; Snap-freeze in -70 ° C isopentane; Cutting the plastic capsule to remove the frozen cylinder of tissue; The tissue cylinder is protected in a cryostat microtome chuck; It can be prepared by cutting into a series of 25-50 sections containing intact tumor cells.

Permanent-sections were rehydrated in 50 mg samples in plastic centrifuge tubes; Pelletize; Resuspend for 4 h fixation in 10% formalin; Washing / pelleting; Resuspend in warm 2.5% agar; Pelletize; Cooling in ice water to cure agar; Remove the tissue / agar block from the tube; The block is infiltrated and embedded in paraffin; It can be prepared by a similar method including cutting into a series of 50 permanent sections.

For IHC assays, sections are layered with blocking solution containing 3% bovine serum albumin in PBS or other blocking reagents. Blocking reagents include non-specific serum or milk powder. Blocking is allowed to proceed for 1 hour at room temperature. Anti-LBC protein antibodies are diluted in a ratio of 1: 100 with PBS buffer containing 3% BSA, 0.1% Triton ™ -100 and tert-octylphenoxypolyethoxyethanol. Sample sections are generally layered at 4 ° C. for 16 hours with antibody solution. Elapsed time and temperature conditions may vary depending on the antibody selected and the material tested. Optimum conditions are determined experimentally. The antibody treated sections are then washed three times in PBS for 15 minutes each to remove unbound antibodies and then layered at 1: 2000 dilution with PBS containing 3% BSA and a second antibody. The second antibody is coupled to a chromogenic enzyme such as horseradish peroxidase, alkaline phosphatase, fluorescein isothiocyanate or other suitable enzyme. Alternatively, a second antibody can be conjugated to biotin and used with chromophore-labeled avidin.

Another exemplary method for detecting the presence of a gene is through in situ hybridization. In general, hybridization in the reaction system includes the following main steps: (1) fixation of the tissue or biological construct to be analyzed; (2) prehybridization treatment of biological constructs to increase accessibility of target DNA and reduce nonspecific binding; (3) hybridization of nucleic acid mixtures to nucleic acids in biological structures or tissues; (4) post-hybridization washes to remove unbound nucleic acid fragments upon hybridization and (5) detection of hybridized nucleic acid fragments. The reagents used in each of these steps and the conditions for use vary depending on the particular application.

In this case, a hybridization solution comprising one or more detectable nucleic acids capable of hybridizing to a gene (at its chromosomal location) is contacted with the cells under hybridization conditions. Thereafter, any hybridization is detected and compared to the predetermined hybridization pattern from normal or control cells. Preferably, the probe is an alpha-isotope probe. Such probes may be commercially available from a number of sources (eg, Visys Inc., Downers Grove, Illinois). In a preferred embodiment, the hybridization solution contains a plurality of probes specific for the region on the chromosome corresponding to the translocation of the sequence making the chimera (eg 15q24-25).

Suitable hybridization protocols for use with the methods of the present invention are described in Albertson (1984); Pinkel (1988); European Patent No. 430,402; And Methods in Molecular Biology, Vol. 33: In Situ Hybridization Protocols, Choo, ed., Humana Press, Totowa, NJ (1994) et al. In one particularly preferred embodiment, see Pinkel et al. (1998) or Kallioniemi (1992). Methods of optimizing hybridization conditions are well known (Tijssen (1993) Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 24: Hybridization With Nucleic Acid Probes, Elsevier, NY).

In a preferred embodiment, the background signal is reduced by using a washing agent (eg C-TAB) or blocking reagent (eg sperm DNA, cot-1 DNA, etc.) to reduce non-specific binding during hybridization. Preferably, hybridization is performed in the presence of about 0.1 to about 0.5 DNA (eg, cot-1 DNA).

Probes can be grown in a biological host or prepared by any method known in the art, including synthetic methods. Synthetic methods include, but are not limited to oligonucleotide synthesis, riboprobes and PCR.

Probes can be labeled with a detectable marker by any method known in the art. Methods for labeling probes include random priming, end labeling, PCR and nick translation. Enzymatic labeling is carried out in the presence of nucleic acid polymerase and the three unlabeled nucleotides and the directly labeled fourth nucleotide contain a linker arm for attaching the label, or the hapten or labeled binding molecule is bound to It can attach to other molecules that can. Suitable direct labels include radiolabels such as ³² P, ³ H, and ³⁵ S, and fluorescent markers such as Fluorescein, Texas Red, AMCA Blue, Lucifer Yellow, Rhodamine, and the like; Cyanine dyes detected by visible light; Enzymes and the like. Labels can also be incorporated chemically into DNA probes directly by bisulfite-mediated transamination or during oligonucleotide synthesis.

Fluorescent markers can be easily attached to nucleotides using an activated linker arm incorporated into the probe. The probe can be used by the method described above to incorporate nucleotides covalently linked to hapten or other molecules such as biotin or digoxigenin and to use labeled antibodies directed to hapten or other molecules, or in the case of biotin, a detectable label Labeling can be done indirectly by the method described above by performing sandwich hybridization using avidin conjugated to. Antibodies and avidins can be conjugated using fluorescent markers or enzyme markers such as alkaline phosphatase or horseradish peroxidase to make them detectable. Conjugated avidin and antibodies are commercially available from companies such as Vector Laboratories (Berlingame, Calif.) And Boehringer Mannheim (Indianapolis, Indiana).

Enzymes can be detected via colorimetric reactions by providing a substrate for that enzyme. In the presence of various substrates, different colors are produced by the reaction, and these colors can be visualized to detect multiple probes separately. Any substrate known in the art can be used. Preferred substrates for alkaline phosphatase include 5-bromo-4-chloro-3-indolylphosphate (BCIP) and nitro blue tetrazolium (NBT). A preferred substrate for horseradish peroxidase is diaminobenzoate (DAB).

Fluorescently labeled probes suitable for use in the in situ hybridization process of the present invention are preferably in the range of 150 to 500 nucleotides in length. The probe may be DNA or RNA, preferably DNA.

Hybridization of detectable probes to cells is performed using probe concentrations of 0.1 to 500 ng / μl, preferably 5 to 250 ng / μl. The hybridization mixture will preferably contain a modifier such as formamide. In general, the hybridization is carried out at 25 ° C to 45 ° C, more preferably at 32 ° C to 40 ° C, and most preferably at 37 ° C to 38 ° C. The time required for hybridization is about 0.25 to 96 hours, more preferably 1 to 72 hours, and most preferably 4 to 24 hours. Hybridization time will vary depending on the probe concentration and the hybridization solution content that may contain accelerators such as hnRNP binding protein, trialkyl ammonium salts, lactams and the like. The slide is then washed with a denaturant such as formamide and a solution containing decreasing concentrations of sodium chloride or a specific solution which removes mismatched probes without binding.

The temperature and salt concentration will vary depending on the desired hybridization stringency. For example, high stringency washes may be performed at 42 ° C. to 68 ° C., while medium stringency may range from 37 ° C. to 55 ° C., and low stringency may range from 30 ° C. to 37 ° C. The salt concentration for the high stringency wash is 0.5-1 fold SSC (0.15 M NaCl, 0.015 M Na citrate), while the medium stringency is 1-4 fold and the low stringency is 2-6 fold SSC.

If desired, the detection incubation step should preferably be carried out in a wet chamber at 23 ° C. to 42 ° C., more preferably 25 ° C. to 38 ° C. and most preferably 37 to 38 ° C. The labeled reagent may be diluted in a solution preferably containing a blocking reagent such as BSA, skim milk powder, and the like. The dilution ratio may range from 1:10 to 1: 10,000, more preferably 1:50 to 1: 5,000, and most preferably 1: 100 to 1: 1,000. Slides or other solid supports are washed between each incubation step to remove excess reagents.

The slide can then be placed and analyzed by microscopy in the case of visually detectable markers or by exposure to radiographic film in the case of radioactive markers. In the case of fluorescent markers, the slides are preferably enclosed in a solution containing an antifade reagent and analyzed using a fluorescent microscope. Multiple nuclei can be tested for increased accuracy of detection.

In addition, assays for expression products of LBC oncogenes can also be used to determine if LBC oncogene mutations occur. Most preferably, this assay is an immunoassay. Immunoassays are binding assays in their simplest and direct aspect. Certain preferred immunoassays are various types of enzymes linked to immunosorbent assays (ELISA) and radioimmunoassay (RIA) known in the art. IHC detection using tissue sections is also particularly useful as in in situ hybridization and enzymatic immunoassays.

In one exemplary ELISA, protein-specific antibodies are immobilized to selected surfaces that exhibit protein affinity, such as wells in polystyrene microtiter plates. Thereafter, test compositions containing the desired antigen, such as clinical samples, are added to the wells. After binding and washing to remove non-specifically bound immune complexes, the bound antigen can be detected. Detection is generally accomplished by adding other antibodies specific for the desired antigen bound to the detectable label. This type of ELISA is a simple "sandwich ELISA." Detection can also be accomplished by adding a second antibody specific for the desired antigen and then adding a third antibody that has binding affinity for the second antibody and is linked to a detectable label.

Modifications of ELISA techniques are well known. In one such modification, the sample containing the desired antigen is fixed on the well surface and then contacted with the antibody of the invention. After binding and appropriate washing, bound immune complexes are detected. If the initial antigen specific for the antibody is linked to a detectable label, the antigen complex can be detected directly. Again, the immune complex can be detected using a second antibody that has binding specificity for the first antigen specific antibody and is linked to a detectable label.

In embodiments of the invention where gene expression is measured to determine AML prognosis or condition, use of a gene expression portfolio is most preferred. A portfolio of genes is a set of genes grouped such that the expression information obtained for them provides a basis for making clinically relevant judgments such as diagnosis, prognosis or treatment choice. In this case, the gene expression portfolio is adapted to assist in the therapeutic decision making for AML patients.

In this regard, disease refers to the alteration of a physical condition that occurs with uncontrolled proliferation of cells and which has the potential to block or disturb or disrupt the proper functioning performance of the body. Some are diagnosed as having a disease if some aspect of the person's genotype or phenotype matches the presence of the disease. However, the action of performing a diagnosis or prognosis may include determination of a disease / condition derived, such as determining the likelihood of recurrence, the type of therapy and the therapy monitoring. In therapy monitoring, a clinical judgment can be made about the effectiveness of a given therapy procedure by comparing the expression of genes over time to determine whether the gene expression profile is changing or in a fashion more consistent with normal tissue. have.

The genes are grouped so that the information obtained about the set of genes in the group provides a sufficient basis for making clinically relevant judgments such as diagnosis, prognosis or treatment selection. These gene sets make up the portfolio of the present invention. As with most diagnostic markers, it is desirable to use the fewest number of markers sufficient to achieve accurate medical judgment. This prevents delays in treatment involving further analysis and unproductive use of time and sources.

One way to establish a gene expression portfolio is through the use of optimization algorithms, such as the mean variance algorithm widely used to establish stock portfolios. This method is described in detail in US patent application 20030194734. In essence, the method seeks to establish a set of inputs (stocks in the economy, expressions measured in intensity herein) that will optimize revenues received for its use (eg, generated signals) while minimizing revenue variations. in need. Many commercial software programs are available on the market to accomplish this task. Preference is given to "Wagner Associates Mean-Variance Optimization Application", referred to herein as "Vagner Software." The software uses functions from the "Wagner Associates Mean-Variance Optimization Library" to determine the efficient frontier and optimal portfolio for which Markowitz theory is preferred. The use of this type of software requires that when the software is used for its intended economic analysis purposes, the microarray data can be modified to be processed as input in the manner in which stock returns and risk measures are used.

Portfolio selection methods may also include the application of discovery rules. Preferably, these rules are formulated based on an understanding of the techniques used to produce biological and clinical results. More preferably, they are applied to the results from the optimization method. For example, an average variance method of portfolio selection can be applied to microarray data for multiple genes differentially expressed in cancer patients. The result from the method may be an optimized set of genes that may include some genes expressed in peripheral blood and diseased tissue. If the sample used in this test method is obtained from peripheral blood and, for example, a particular gene differentially expressed in cancer is expressed differently in peripheral blood, an efficient borderline excluding the gene differentially expressed in peripheral blood The discovery rule can be applied to select a portfolio from. Of course, this rule can be applied before the formation of an efficient boundary, for example during data preselection.

Other discovery rules may be applied that are not necessarily relevant to the biology in question. For example, rules can be applied so that only a defined percentage of the portfolio can be represented by a particular gene or group of genes. Commercially available software, such as Wagner Software, already accepts this type of discovery. For example, this may be useful if factors other than accuracy and precision (eg, expected license tax) affect the preference of one or more gene inclusions.

The gene expression profile of the present invention can also be used in conjunction with other non-genetic diagnostic methods useful for cancer diagnosis, prognosis or therapeutic testing. For example, in some situations it is advantageous to combine data from conventional markers such as serum protein markers (eg, cancer antigen 27.29 (“CA 27.29”)) with the diagnostic power of gene expression based on the methods described above. . There is a wide range of such markers, including analytes such as CA 27.29. In this method, blood is taken regularly from the treated patient and then subjected to an enzyme immunoassay for one of the serum markers described above. If the concentration of the marker indicates recurrence of the tumor or failure of treatment, a sample source suitable for gene expression analysis is collected. If a suspicious mass is present, fine needle aspirate (FNA) is taken and the gene expression profile of the cells taken from the mass is analyzed as described above. Alternatively, tissue samples may be collected from areas adjacent to tissue where the tumor has already been removed. This method can be particularly useful if other tests yield ambiguous results.

Kits made in accordance with the present invention include a formatted assay for determining gene expression profiles. These may include all or some of the materials required to perform the assay, such as reagents and instructions, and the medium in which the biomarker is assayed.

Preferred methods (including those used to reach interpretation of related biological pathways) to achieve gene expression profiles include determining the amount of RNA produced by a gene capable of encoding a protein or peptide or capable of transcribing RNA. do. This is best accomplished with reverse transcription PCR (RT-PCR), competitive RT-PCR, real time RT-PCR, differential display RT-PCR, Northern blot analysis and other related tests. While it is possible to perform this technique using individual PCR reactions, it is desirable to amplify copy DNA (cDNA) or copy RNA (cRNA) produced from mRNA and analyze it via microarray. Many different array structures and manufacturing methods are known to those skilled in the art and are described in US Pat. Nos. 5,445,934; 5,532,128; 5,532,128; 5,556,752; 5,556,752; 5,242,974; 5,242,974; 5,384,261; 5,384,261; 5,405,783; 5,405,783; 5,412,087; 5,412,087; No. 5,424,186; 5,429,807; 5,429,807; 5,436,327; 5,436,327; 5,472,672; 5,472,672; 5,527,681; 5,529,756; 5,545,531; 5,545,531; 5,554,501; 5,554,501; 5,561,071; 5,561,071; 5,571,639; No. 5,593,839; 5,599,695; 5,599,695; 5,624,711; 5,624,711; 5,658,734; 5,658,734; And 5,700,637.

Microarray technology enables the simultaneous measurement of steady-state mRNA levels of thousands of genes, providing a powerful means of identifying effects such as initiation, arrest or modulation of uncontrolled cell proliferation. Currently, two microarray technologies are used for a wide range of applications. The first is a cDNA array and the second is an oligonucleotide array. Although there are differences in the fabrication of these chips, all top-down data analysis and results are essentially the same. The product of these assays is generally a measure of signal intensity received from labeled probes used to detect cDNA sequences from samples that hybridize to nucleic acid sequences at known positions on the microarray. In general, signal intensity is proportional to the amount of cDNA and thus mRNA expressed in sample cells. Many such techniques are available and useful. Preferred methods for measuring gene expression are described in US Pat. No. 6,271,002; No. 6,218,122; 6,218.114 and 6,004,755.

Analysis of expression levels is performed by comparing signal intensities and applying these measurements to statistical algorithms. This is best done by creating a ratio matrix of gene expression intensity in the test sample to expression intensity in the control sample. For example, gene expression intensity of drug treated tissues can be compared with expression intensity generated from the same tissue not treated with drug. This ratio of expression intensities represents a fold change in gene expression between the test sample and the control sample.

In addition, gene expression profiles can be expressed in a number of ways. The most common method is to arrange the original fluorescence intensity or ratio matrix in graphical dendograms where the columns represent the test samples and the rows represent the genes. The data are arranged such that genes with similar expression profiles are adjacent to each other. The expression ratio of each gene is visualized by color. For example, if the expression ratio is less than 1 (indicating downregulation), it can be shown in the blue region of the spectrum, and if the expression ratio is greater than 1 (indicating upregulation), it can be represented in color in the red region of the spectrum. Such data can be represented using commercially available computer software programs including Silicon Genetics, "GENESPRINT" from Incorporated and Partec, "DISCOVERY" and "INFER" software from Incorporated.

Differentially expressed genes are upregulated or downregulated in diseased cells as inferred by the evaluation of gene expression as described above. Upregulation and downregulation are relative terms meaning that detectable differences (which exceed the contribution of noise in the system used to measure them) are found in the amount of expression of the gene relative to some baseline. In this case, the baseline is the measured gene expression of normal cells. Thereafter, the target gene in diseased cells is up- or down-regulated relative to baseline using the same measurement method. Preferably, the level of up and down regulation is distinguished based on a fold change in the intensity measurement of the hybridized microarray probe. A 1.5-fold difference is desirable to make this distinction. That is, before the gene is said to be differentially expressed in the treated, diseased cells as compared to the untreated, diseased cells, the treated cells gain at least 1.5 times, or less than 1.5 times, intensity than the untreated cells. Turned out to be. A 1.7-fold difference is more preferred and at least a 2-fold difference is most preferred for measuring gene expression.

One method of the invention involves comparing gene expression profiles for various genes to determine if an individual responds to the use of a therapeutic agent. Gene expression profiles that distinguish responders from non-responders are established and each gene expression profile is immobilized in the medium, such as a computer readable medium as described below. Patient samples containing diseased cells (eg hematopoietic stem cells in the case of AML) are obtained. Most preferably, the sample is a bone marrow sample and is extracted from the sternum or iliac tomb of the patient according to conventional methods. Preferably the bone marrow aspirate is processed to be enriched for leukemia blasts using conventional methods. Subsequently, sample RNA is obtained and amplified from diseased patient cells and gene expression profiles are preferably obtained via microarrays for genes in the appropriate portfolio (for large gene portfolios). The expression profile of the sample is then compared with what has already been analyzed for prognostic results. When few genes are used in the same portfolio as when three gene profiles are used, sample nucleic acid amplification and detection schemes are the most preferred method of measuring gene modulation. In such cases, PCR, NASBA, rolling circle, LCR, and other amplification pathways known to those skilled in the art can be used, with PCR being most preferred. Where it is desirable for the portfolio to include multiple genes or to measure the expression of multiple other genes, it is desirable to evaluate the expression pattern based on the measurement of the intensity of the microarray as described above.

In a similar fashion, gene expression profile analysis can be performed to monitor treatment response. In one aspect of this method, gene expression analysis as described above is performed in a patient treated with a particular suitable treatment at various time periods through the course of treatment. If the gene expression pattern is consistent with the positive result, the patient's therapy is continued. If not, the patient's therapy is altered using additional therapy, a change in dose or removal of the current treatment. Such assays allow for adjustment and therapy adjustment before or on detectable clinical signs.

In the context of the molecular markers of the invention, many other formats and approaches are useful for diagnostic applications. Methylation of genomic regions can affect gene expression levels. For example, hypermethylation of gene promoter regions can consistently down-regulate gene expression while hypomethylation can lead to an increase in steady-state mRNA levels. As such, detection of methylation regions associated with genes that predict drug response, prognosis or condition can be used as an alternative method for diagnosing gene expression levels. Such methods are known to those skilled in the art. Alternatively, a single nucleotide polymorphism (SNP) present in the promoter region may also affect the transcriptional activity of the gene. Thus, detection of such SNPs by methods known to those skilled in the art can be used as diagnostic agents for detecting genes that are differentially expressed with different prognostic results.

The products of the present invention exhibit gene expression profiles useful for treating, diagnosing, prognosticing, timing and otherwise evaluating diseases. Preferably, they are reduced to automatically readable media such as computer readable media (magnetic, optical, etc.). These products may also include instructions for assessing gene expression profiles in such media. For example, the product may comprise a CD ROM with computer instructions for comparing the gene expression profile of the portfolio of genes described above. The product also has a digitally recorded gene expression profile so that it can be compared to gene expression data from patient samples. Alternatively, the profile can be recorded in different representation formats. Clustering algorithms, such as those incorporated in "DISCOVERY" and "INFER" from Partec Incorporated, described above, can best assist in the visualization of such data.

Further products according to the invention are kits for performing the assays described above. Each such kit includes instructions in reagents conventional in human or machine readable form and the assay type described. These may include, for example, nucleic acid arrays as described above (eg, cDNA or oligonucleotide arrays) arranged to recognize gene expression profiles of the present invention. They also include, for example, reverse transcriptase, reverse transcriptase primers, corresponding PCR primer sets, thermostable DNA polymerases (e.g. Taq polymerases), and suitable detection reagent (s) (e.g. scorpion probes, fluorescent probe probes). , Reagents used to perform nucleic acid amplification and detection, including molecular beacon probes, single dye primers or fluorescent dyes specific for double-stranded DNA (eg, ethidium bromide). Kits for detecting surface antigens are based on containing staining material or comprising components such as buffers, anti-antigenic antibodies, detection enzymes and substrates such as horseradish peroxidase or biotin-avidin-based reagents. It is an antibody. Kit components for detecting blast cells generally include reagents for performing flow cytometry, blast adsorption assays and other common blast assays.

Common anticancer agents include, but are not limited to, tyrosine kinase inhibitors, MEK kinase inhibitors, P13K kinase inhibitors, MAP kinase inhibitors, apoptosis modulators and combinations thereof. The most preferred of these drugs are Novartis's "GLEEVEC" tyrosine kinase inhibitors, U-0126 MAP kinase inhibitors, PD-098059 MAP kinase inhibitors, SB-203580 MAP kinase inhibitors and antisenses, ribozymes and DNAzyme , Bcl-XL, and anti-apoptosis agents. Examples of other useful drugs include carnolides of US Pat. No. 6,306,897; Substituted bicycles of US Pat. No. 6,284,764; Indoline of US Pat. No. 6,133,305; And antisense oligonucleotides of US Pat. No. 6,271,210; Platinum coordination compounds, such as cisplatin or carboplatin, taxane compounds, for example paclitaxel or docetaxel, camptothecin compounds such as irinotecan or topotecan, anti-tumor vinca alkaloids such as , Vinblastine, vincristine or vinorelbine, anti-tumor nucleoside derivatives such as 5-fluorouracil, gemcitabine or capecitabine, nitrogen mustard or nitrosourea alkylating agents such as cyclophosph Pamide, chlorambucil, carmustine or robustin, anti-tumor anthracycline derivatives such as daunorubicin, doxorubicin or idarubicin; HER2 antibodies such as trastuzumab; And anti-tumor grapephytotoxin derivatives such as etoposide or teniposide; And estrogen receptor antagonists or selective estrogen receptor modulators, preferably tamoxifen, or alternatively toremifene, droroxifene, parslodex and raloxifene, or exemestane, anastrozole, retra Aromatase inhibitors such as sol and borosol.

The anticancer agent may also include therapeutic agents directed against gene therapy or antisense therapy or RNA interference. These include, but are not limited to, oligonucleotides having sequences complementary to mRNA sequences that can be introduced into cells to block the translation of mRNA, ie, to block the action of genes encoding mRNA. The use of oligonucleotides to block gene expression is described, for example, in Strachan and Read, Human Molecular Genetics, 1996. Such antisense molecules may be stable derivatives of DNA such as DNA, phosphorothioate or methylphosphonate, stable derivatives of RNA such as RNA, 2′- O -alkylRNA, or other antisense oligonucleotide mimetics. Antisense molecules can be introduced into cells by microinjection, liposome encapsulation, or by expression from a vector with antisense sequences.

In gene therapy, the gene of interest can be linked into a viral vector that mediates the transfer of therapeutic DNA by infection of the receptor host cell. Suitable viral vectors include retroviruses, adenoviruses, adeno-associated viruses, herpes virus, Bexonia virus, polio virus and the like. Alternatively, the therapeutic DNA may be gene therapy by non-viral technology, lipofection membrane fusion or direct microinjection involving receptor-mediated targeted DNA delivery using ligand-DNA conjugates or adenovirus-ligand-DNA conjugates. Can be transferred intracellularly. These procedures and variants thereof are suitable for ex vivo and in vivo gene therapy. Protocols for molecular methods of gene therapy suitable for use with genes are described in Gene Therapy Protocols, edited by Paul D. Robbins, Human press, Totowa NJ, 1996.

Compounds identified according to the methods described herein can be used alone at appropriate doses defined by routine tests to minimize any potential toxicity while obtaining optimal inhibition or activity. In addition, co- or continuous administration of other agents may be desirable.

The invention is also listed in the following non-limiting examples. All references cited herein are hereby incorporated by reference.

Clinical Evaluation and Response Definition

This study is part of an open label, multicentre, non-comparison phase 2 clinical study, where relapsed or refractory AML patients are reviewed by Harousseau et al. (2003) were treated with Tipifarnib at a starting oral dose of 600 mg bid for the first 21 consecutive days of each 28-day cycle. Patients were divided into two groups, relapsed AML patients and refractory AML patients. A total of 252 patients (135 relapsed patients and 117 refractory patients) were treated. Eighty patients were selected to provide bone marrow samples for RNA microarray analysis, which required separate notification. The overall response rate was relatively low in this study.

Thus, for the purposes of gene expression profiles, the response to Tipiparnib may be directed to objective response (complete relief [CR], complete relief [CRp] with incomplete platelet recovery, or partial relief [PR], central observation or clinical site). Patients with hematological response (> 50% reduction of leukemia blasts in bone marrow) or stable disease (no hemologic response as well as disease progression) measured by both central observation and clinical site. Complete relief with incomplete platelet recovery was defined similarly, except for platelet counts of less than 1000,000 / μl sufficient to ensure transfusion independence. > 50,000 / μl), defined as a reduction of at least 50% in bone marrow blasts with a recovery of more than 4 weeks after initial documentation.

Sample Acquisition and Microarray Processing

Bone marrow samples were collected from patients prior to treatment with Tipifarnib, diluted with phosphate buffered saline (PBS) and centrifuged with picol-ditrizoate (1.077 g / mL). Leukocyte cells were washed twice with PBS, resuspended in fetal bovine serum ((FBS) and 10% dimethyl sulfoxide (DMSO) and immediately stored at −80 ° C. The cells were thawed and total RNA was extracted from the cell samples using the RNeasy Kit [ Extracted using Qiagen, Valencia, Calif. RNA quality was checked using an Agilent Bioanalyzer Synthesis of cDNA and cRNA was Affymetrix [California] The protocol was performed according to Santa Clara, Prod.

Microarray Processing

Two rounds of linear amplification are performed because the RNA yield for some samples is so low that one round amplification cannot be used to sufficiently obtain labeled cRNA for chip hydration. 11 μg of cRNA was randomly fragmented by incubation in 40 mM Tris-acetate, pH 8.1, 100 mM potassium acetate, and 30 mM magnesium acetate for 35 minutes at 94 ° C. Fragmented cRNA was hybridized to a U133A array in a rotisserie oven set at 60 rpm for 45 hours at 45 ° C. After hybridization, the array was washed (using 6x SSPE and 0.5x SSPE containing Triton X-100 [0.005%]) and streptavidin-phycoerythrin (SAPE; Molecular Probes, Yuzen, Oregon). ) Manufacturer). Titration of bound label probes was performed using an Agilent G2500A Genearray Scanner (manufactured by Agilent Technologies, Palo Alto, Calif.).

The total fluorescent intensity for each array was scaled to a uniform value of 600. Chip performance was adequate by calculating the signal as a noise ratio (column average signal / noise). Chips were removed from further analysis when their signal-to-noise ratio was less than 5. Genes were included in further analysis only when they were said to be "existent" in the chip at least 10%. 11723 Affymetrix probe sets remained after this cut-off. The quality of gene expression data was further controlled by identifying external components based on basic component analysis and analyzing the normal distribution of gene intensity (Partek Pro V5.1).

Statistical analysis

Percentile analysis was used to identify genes that predicted the response as highly sensitive. Up- or down-regulated genes were identified in 100% of responders compared to over 40% of non-responders. The chi-squared test and Student's t-test were used to test the significance of the relationship between patient covariates and patient response including ras mutation status and gene expression. Unexpected k-means and phylogenetic clustering were performed in Omniviz. Prediction values for the selected genes were analyzed by leave-one-out and rib-five-out cross validation methods. Here, one (or five) sample (s) were removed from the data set and the markers were reselected from 11,723 genes. Predictive values of the genes were tested on left-out samples using linear discriminant analysis. Sensitivity was calculated by dividing the actual positive number detected by the test by the sum of the actual positive and false negatives. Specificity was calculated by dividing the actual number of detected negatives by the sum of the actual negative and false positives. Positive predictive values were calculated by dividing the actual positive number by the number of actual positive and false positive numbers. The speech prediction value was calculated by dividing the actual speech number by the number of real speech and false speech. A positive similar ratio of patients responding to treatment is sensitivity divided by 1-specificity. The receiver operator curve (ROC) was used to select the appropriate threshold for each classifier requiring 100% sensitivity. ROC diagnosis calculates sensitivity and specificity for each parameter.

Real Time RT-PCR Check

TaqMan ^® real-time RT-PCR was used to verify microarray results of the AHR and AKAP13 genes. For each 1 μg sample of amplified RNA, cDNA was prepared using T7 oligo (dT) primers and Superscript II reverse transcriptase according to the manufacturer's instructions (Invitrogen). Primers and MGB-probes for the AKAP13 gene and control gene PBGD were designed using Primer Express (Applied Biosystems Manufacturer), while those for the AHR gene and control gene HPRT were assay-on-demand from ABI. Available as Assets-on-Demand. The primer / probe sequence for AKAP13 is as follows: AKAP13 omni, 5'ggtcagatgtttgccaaggaa3 '(SEQ ID NO: 1); AKAP13 reverse, 5'tcttcagaaacacactcccatc-3 '(SEQ ID NO: 2); AKAP13 probe, 6FAM-tgaaacggaagaagcttgtA-3 ′ (SEQ ID NO: 3).

All primers and probes were tested for at least 90% optimal amplification efficacy. Relative standard curves consisted of 5 dilutions (10-fold each) of HeLa cDNA (in most cases ranging from 25 ng to 2.5 pg). RT-PCR amplification mixture (25 μl) was prepared with 100 ng of template cDNA, 2 × TaqMan ^® Universal PCR Master Mix [12.5 μl; Applied Biosystems, 500 nM forward and reverse primers, and 250 nM probes. The reaction was performed using an ABI PRISM 7900HT Sequence Detector (Applied Biosystems, Inc.). Cycle conditions were as follows: AmpErase UNG activation at 50 ° C. for 2 minutes, polymerase activation at 95 ° C. for 10 minutes and 50 cycles at 95 ° C. for 15 seconds and 60 seconds at annealing temperature ((59 ° C. or 60 ° C.)). In each assay, a standard curve and a template-free control group were included three times for the target gene and the control gene with template cDNA The relative amounts of each gene were calculated based on the standard curve and the amount of control gene The median coefficient of variation (based on the amount calculated) of the three samples was 8% The correlation between repeated runs using a template diluted independently from stock was> 0.95. When the TaqMan ^® test showed a reproducible result, it was compared with microarray data.

Cell Line Culture and AKAP13 Overexpression Assay

AKAP13 vectors, oncoLBC and protoLBC, and vector control (pSRalpha-neo) were obtained from Dr. Deniz Toksoz. Zheng et al. (1995)]. HL60 cell lines were obtained from American tissue culture collection and grown in RPMI 1640 and 10% FBS. Cells were transiently transfected with respective vectors using Effectene reagent (Qiagen) and maintained for 7 days under G418 (600 μg / mL). Tipifarnib was added at various concentrations (0, 1.5, 3.1, 6.3, 13, 25, 50, 100, 200, 1000, and 10,000 nM) to duplicate the cultures (1.5 × 10 5 cells / mL). Cells were counted on day 6. Cell numbers were normalized to drug free cultures to obtain% of viable control cells.

result

Expression Profiling of Relapsed and Refractory AML

FTI was originally designed to specifically inhibit FTase activity, thus blocking the oncogenic ras pathway. Accordingly, Applicants first analyzed DNA for activating ras mutations from the bone marrow of 80 patients with relapsed or refractory AML and examined the possible association between ras mutations and the response to Tipifarnib. Although 26% of AML samples carry N-ras mutations, the mutation status was not related to the desired response or overall survival. Harousseau et al. (2003). Accordingly, Applicants performed gene expression profiling to identify new signals that can be used to predict the response to FTI Tipifarnib. Bone marrow samples were obtained for gene expression analysis from 80 patients prior to treatment with Tipifarnib. Table 1 shows the patient information.

58 of 80 samples passed quality control criteria, including RNA quality and chip performance. There were no significant differences in age, sex, AML class (relapsed or refractory), progressive risk factors, baseline blast counts, response and overall survival between these 58 patients and the rest of the clinical study population (N = 194; Table 2).

Gene expression data was integrated using clinical information and retrospective analysis was performed to identify genes that could separate responders from non-responders with high levels of sensitivity. Data was applied to several filtering steps before identifying differentially expressed genes. First, genes that were not expressed in at least 10% of the samples were removed. This reduced the number of genes from approximately 22,000 to 11,723 genes. For unsupervised analysis, genes that showed little variation in expression according to the dataset (<45% coefficient of variation for all samples) were excluded and quantile normalization was applied to the remaining 5,728 genes. At this stage, unsupervised k-means clustering analysis was performed to identify any differences between patients based on their overall gene expression profiles. Six major clusters of patients were identified using this technique. No separation between responders and non-responders was observed (FIG. 1). Only a small amount of genes can be associated with the anti-tumor effect of FTI, for example, differential expression of a single gene included in FTI biology affects the clinical response due to noise introduced from other 11,722 genes. Can be shielded.

Example 2

Identification of differentially expressed genes between responders and non-responders

Applicants then performed supervised analysis using gene expression data to identify genes differentially expressed between all responders and at least 40% of non-responders. These criteria were selected to identify genes that can predict the response to Tipiparnib with the highest possible level of sensitivity. From 11,723 genes, a total of 19 genes can stratify responders and non-responders (shown in more detail in Tables 3 and 10) and can provide significant P values in the t-test (P <0.05). Confirmed. Genes included in these included signal transduction, apoptosis, cell proliferation, tumorigenesis and potentially FTI biology (ARHH, AKAP13, IL3RA).

Real-time RT-PCR Demonstration of Genetic Markers

To demonstrate microarray gene expression data, TaqMan ^® real-time RT-PCR was performed on the cDNA used to generate labeled target cRNA for microarray hybridization. Two genes were selected to verify gene expression data. The use of the AHR and AKAP13 genes resulted in the highest levels for responders, so these genes were selected. The correlation coefficient was 0.74 for AHR and 0.94 for AKAP13, indicating that the microarray gene expression data can be verified by PCR (FIG. 2).

Identification of the AKAP 13 Gene as a Marker of Resistance

AKAP13 was overexpressed in patients resistant to Tipifarnib. Predictive values of this gene were calculated from 58 samples using rib-one-out crossover identification (LOOCV; FIG. 3A). AKAP13 gene expression was predicted to be non-reactive with a negative predictive value (NPV) of 96%, and low expression levels mediated the response of a positive predictive value (PPV) of 43% (χ 2 = 13.7; P = 0.0022). Overall diagnostic accuracy was 69% and the probability of a positive response was 2.4. Thus, stratification of these patient clusters based on AKAP13 gene expression increased the response rate from 24% (14/58) of the total group to 43% (13/30) among patients with low expression genes. Expression values for the AKAP13 gene in each patient are shown in Figure 3B. When survival was analyzed by Kaplan-Meier analysis, the median survival of patients with low expression of these genes was at least 90 days longer than that of patients with high expression values (P = 0.008; FIG. 3C).

Identification of a minimum set of three genetic markers

LOOCV was used to identify a candidate set of gene markers capable of predicting a response to Tipiparnib with improved accuracy when compared to AKAP13 alone. Classifiers were prepared with increasing number of genes based on t-test P values and the error rates of these classifiers were calculated using LOOCV while maintaining the predicted response sensitivity at 100% (FIG. 4A).

The 3-gene classifier can predict the response with the lowest error rate (Figure 4A). This was also observed when performing a rib-five-out cross validation. The error rate increased when more genes were added, indicating that additional genes introduced noise as a classifier. For the 3-gene classifier, LOOCV demonstrated 94% NPV and 48% PPV with 74% overall diagnostic accuracy and 2.9 positive likelihood ratio (FIG. 4B). The combined expression values for the three genes in each patient are shown in Figure 4C. Thus, for the patient group with this gene signal, the response rate to Tipiparnib was 48% (12/25) compared to 24% (14/58) in the patient cluster.

Using 3-gene signals (AHR, AKAP13 and MINA53), Kaplan-Meier analysis again showed a significant difference in survival between the predicted and non-responder groups (FIG. 4D). Thirteen patients incorrectly classified as responders had better total survival compared to 31 patients correctly classified as non-responders (FIG. 5). Interestingly, only two patients misclassified as non-responders demonstrated a hematological improvement of relatively short overall survival time (71, 87 days).

Overexpression of AKAP13 to Increase Resistance to Tipiparnib in AML

The AKAP13 gene was the most potent marker of resistance to Tipiparnib. Therefore, we tested their relevance in FTI biology by overexpressing the oncoLBC and protoLBC variants of the gene in the HL60 cell line. Thereafter, transient transfection factors were tested for sensitivity to Tipiparnib. Overexpression of both AKAP13 variants in this AML cell line model resulted in about a 20-fold increase in resistance to Tipiparnib compared to control cells (FIG. 3). Both LBC oncogenes and proto-oncogenes increased resistance to Tipifarnib to the same extent as observed by parallel right shifts of the death curve by at least one log-unit compared to the control.

Argument

Both groups identified gene expression profiles of newly diagnosed adult AML patients useful for recently predicted clinical outcomes. Bullinger et al. (2004); And Valk et al. (2004)]. These profiles are believed to be more powerful than currently used prognostic markers such as karyotyping. In addition, standard chemotherapy [Chang et al. (2003); Okutsu et al. (2002); And Cheok et al. (2003) and novel selective anticancer agents [Hofmann et al. (2002); And McLean et al. (2004), a response profile has been found that predicts the response to anticancer compounds. Similarly, pharmacogenetic profiles related to patient response to the tyrosine kinase inhibitor gefitinib have recently been discovered. Paez et al. (2004) and Lynch et al. (2004)]. In this study, subgroups of non-small cell lung cancer patients had mutations activated in the target epithelial growth factor receptors associated with clinical response to targeted therapy.

In phase 2 studies of relapsed and refractory AML patients, we identified gene expression profiles that predicted response to Tipifarnib, a new farnesyl transferase inhibitor. This class of compounds is used for the treatment of hematologic malignancies. Karp et al. (2001); Kurzrock et al. (2004); Alsina et al. (2003); Cortes et al. (2003); And Thomas et al. (2001) and solid tumors such as breast cancer (Johnston et al. (2003)] and recurrent glioma [Brunner et al. (2003)]. However, although clinical responses have been demonstrated, there is an increasing need to modulate therapy by identifying patients who are most likely to respond to the drug and thus are the best candidates. In addition, although ras was considered to be a major target of this class of drugs, some clinical studies have shown that they are not necessarily effective in clusters with a high frequency of ras mutations. Van Cutsem et al. (2004); And Rao et al. (2004)].

Several genetic markers have been identified that are efficacious in predicting the response to tipiparnib. A subset of these markers is predictive of drug response and is thought to be potentially involved in FTI biology. One of the top candidates found from the microarray studies was lymphocyte blast seizures oncogenes (oncoLBC or AKAP13). The gene is a guanidine nucleotide exchange factor for Rho protein [Zheng et al. (1995) and protein kinase A anchoring proteins (Carr et al. (1991). AKAP13 contains a region similar to the α-helical domain known to interact with Lamin B. Foisner et al. (1991)]. This association leads to lamin B activation through protein kinase A, resulting in increased mitotic activity. Both RhoB and Lamin B are farnesylated and are candidate targets for FTI. AKAP13 is also a proto-oncogene because loss of its 3-prime terminus leads to cellular transformation. See Sterpetti et al. (1999). Although this was originally confirmed from patients with chronic myelogenous leukemia, its expression has not been demonstrated in AML.

Identification of several genes tentatively included in FTI biology (ARHH, AKAP13, IL3RA) supports that the interaction of multiple pathways can affect how FTI acts in these clusters of AML patients (FIG. 7). ). These genes interact with several farnesylated proteins, including ras, rho, and potentially lamin B. Rho protein is a very important anti-tumoral target for FTI. Sahai et al. (2002); And Lancet et al. (2003). RhoB, RhoA, and RhoC have been found to be overexpressed in many cancer types. Sahai et al. (2002)]. Moreover, RhoH (ARHH) is often re-arranged in myeloid-derived tumors and this re-arrangement can lead to its overexpression. Pasqualucci et al. (2001). Although most of these Rho proteins are geranigeranylated, they interact closely with each other to farnesylate ras, RhoE, and RhoB small GTPases. Sahai et al. (2002); And Li et al. (2002)]. In addition, RhoH, RhoB, and RhoE have been found to act as an antagonistic mode for the transgenic ability of RhoA and RhoG. Li et al. (2002)]. The activity of RhoA, and possibly other related bovine GTPases, is increased by guanine nucleotide exchange factor lymphocyte blast seizures oncogene (AKAP13). See Sterpetti et al. (1999); And Toksoz et al. (1994)]. In addition, AKAP13 can increase mitotic activity by activating Lamin B through protein kinase A. See Foisner et al. (1991)]. IL3 receptors are well known to activate the ras pathway. Testa et al. (2004)]. Thus, as shown in FIG. 7, increased activity of IL3RA and AKAP13, and a decrease in RhoH expression resulted in an increased cell profile of transformation. This allows leukocyte blasts to overcome the anti-tumorogenic effects of FTI through the recruitment pathway. In contrast, when IL3RA and AKAP13 are underexpressed and RhoH activity is increased, FTI may be more effective at blocking this pathway.

Finally, Applicants demonstrated that overexpression of AKAP13 (both oncoLBC and protoLBC variants) increased the IC ₅₀ of the HL60 AML cell line approximately 20-fold. This indicates that overexpression of AKAP13 is a relevant marker of resistance and may be useful as an alternative drug target for patients resistant to Tipiparnib.

In total, Applicants' findings allow for gene expression based on diagnostic assays to identify patients who tend to respond to Tipifarnib. This information can be used to better direct treatment to the appropriate patient population. Using survival as a gold standard, gene signaling predicts response levels to therapies that can be predicted using conventional clinical response categories. In contrast, this raises the question of whether the genetic signal for predicting response to FTI treatment is of diagnostic value independent of FTI therapy. Accordingly, we evaluated the prognostic signs already identified in newly diagnosed AML patients treated with conventional chemotherapy. Bullinger et al. (2004)]. The signal indicated its use in current patient clusters, but our 3-gene signal also stratified this poor and good prognostic group, indicating that it was a predictor of response to FTI.

Example 3

Analysis of AML Prognostic Gene Signals

The 3-gene signal can predict the diagnosis regardless of the type of drug treatment. To determine this, we first assessed recently identified gene-expression signals in newly diagnosed AML patients treated with conventional chemotherapy. Bullinger et al. (2004)]. The signal was defined using a cDNA array, so we first matched these genes with probes present on the Affymetrix gene chip. Of the 133 predictive genes identified by Bullinger et al., 167 probe sets (corresponding to 103 unique genes) matched the Affymetrix U133A chip. Three genes identified in the analysis of the present invention are not present in the list of 133 genes such as Bullinger et al. (SEQ ID NO: shown in FIG. 4). Two major groups of patients were defined as hierarchical clustering using 167 probe sets (FIG. 8A). Kaplan-Meier analysis showed clear stratification of these clusters into patients with good and poor prognosis (FIG. 8B, p = 0.0003). Accordingly, our data indicate that a subset of the 133-gene prognostic signals identified by Bullinger et al. (2004) can also be used in a relapsed and refractory cohort of patients. As a result, this indicates that the prognostic gene profile is surprisingly robust with different microarray platforms and different classes of AML.

None of the clusters defined by the prognostic gene signal had more significant responders. However, when the Tipiparnib 3-gene signal was applied to a good and poor prognostic group, patients responding to Tipiparnib were also stratified from both prognostic groups (FIG. 8C). Thus, three-gene signals have applications that are independent of prognostic signals and are specific for FTI treatment in this cluster of patients.

Example 4

Clinical Evaluation and Response Definition

The present study is an open trial to test the efficacy and stability of farnesyl transferase inhibition using Tipiparnib administered as a single agent in AML, starting with the oral dose of 600 mg (every other day) for the first 21 days of the 28-day cycle. A multicenter, non-comparison phase 2 study of markers. Patients were enrolled in two cohorts: relapsed AML and refractory AML. A total of 252 patients (135 relapsed patients and 117 refractory patients) were treated. Patients with the desired response (CR, CRp, or PR) (as described above) for the response to Tipifarnib for the purpose of gene expression profiling, or at the clinical site by central observation or at a particular time subsequent thereto. As defined by patients as defined by patients as hematological response (reduction of> 50% of leukocytes) or a stable disease identified.

Sample Acquisition and Microarray Processing

All samples were obtained from patients who accepted the described processing and analysis. Bone marrow samples were collected from patients prior to treatment with Tipifarnib, diluted with PBS and centrifuged with Ficoll-diatrizoate (1.077 g / ml). Leukocytes were washed twice with PBS, resuspended in FBS and 10% DMSO and immediately stored at -80 ° C. The cells were thawed and total RNA was extracted from the cell samples using the RNeasy kit (Quiagen, Valenciaga, Calif.). RNA quality was checked using an Agilent Bioanalyzer. Synthesis of cDNA and cRNA was performed according to the Affymetrix [Santa Clara, Calif.] protocol. Two rounds of linear amplification are performed because the RNA yield for some samples is too low to obtain sufficiently labeled cRNA for chip hybridization with one round of amplification.

For hybridization, 11 μg of cRNA was randomly fragmented by incubation in 40 mM Tris-acetate, pH 8.1, 100 mM potassium acetate, and 30 mM magnesium acetate for 35 minutes at 94 ° C. Fragmented cRNA was hybridized with a U133A array in a rotisserie oven set at 60 rpm at 45 ° C. for 16 hours. Following hybridization, the array was washed (using 6x SSPE and 0.5x SSPE containing Triton X-100 (0.005%)) and streptavidin-phycoerythrin [SAPE; And Molecular Probes, Yugen, Oregon. Titration of bound and labeled probes was performed using an Agilent G2500A Genearray Scanner (Agilent Technologies, Palo Alto, Calif.).

The total fluorescent intensity for each array was evaluated to a uniform value of 600. Chip performance was optimized by calculating the signal (column average signal / noise) for the noise ratio. Chips were removed from further analysis when their signal-to-noise ratio was less than 5. If the gene is said to be "present" in more than 10% of the chips, it was included in further analysis. After this cut-off there were approximately 12,000 Affymetrix probe sets. Gene expression data quality was controlled by identifying external factors and analyzing the normal distribution of gene intensities based on basic component analysis (Partek Pro V5.1).

Statistical analysis

Hierarchical clustering and clustering under unsupervision were performed in omnibiz. Kaplan-Meier analysis was performed using S-Plus.

Example 5

Prognostic Signs Identified in New AML for Use in Recurrent and Refractory Patients

Two publications have recently been published describing their use in predicting gene-expression profiles and clinical outcomes in newly diagnosed adult AML patients. Bullinger et al. (2004); And Valk et al. (2004)]. Applicants profiled 58 patients with relapsed and refractory AML using the Affymetrix U133A gene chip. Of the 133 predictive genes identified by Bullinger et al., 167 probe sets (corresponding to 103 unique genes) were identified on the U133A chip (FIG. 9) [Bullinger et al. (2004)]. The 167 probe sets are listed in the sequence listing table and designated by the sequences shown in Table 4.

Two major groups of patients were defined by hierarchical clustering using these 167 probe sets (FIG. 10A). Kaplan-Meier analysis showed clear stratification of these clusters into patients with good and poor prognosis (FIG. 10B, p = 0.0000219). Accordingly, our data indicate that a subset of 103 genes of the 133-gene prognostic signal identified by Bullinger et al. (2004) can also be used in a relapsed and refractory cohort of patients (Table 4). As a result, this indicates that the prognostic gene profile is very robust according to different microarray platforms, different classes of AML, and different treatment algorithms.

The prognostic signal is independent of the 3-gene signal, which predicts the response to tipiparnib.

Applicants have identified 3-gene signals (AHR, AKAP13, MINA53) that predict response to Tipiparnib in relapsed and refractory AML patients. These genes can stratify patients into groups of good and poor prognostic outcomes (FIG. 11B, p = 0.002). The question arises whether these gene signals predict a response to FTI treatment or generally only identify patients with good prognosis. When the 3-gene signal was applied to the good and poor prognostic groups, the responders were further stratified from the prognostic group (FIG. 11C, p = 0.000003). Following the application of both gene signals, there is a clear stratification of a group of patients who do not respond to Tipifarnib and have a poor prognosis regardless of the type of treatment (FIG. 11D, p = 0.00005). Thus, the 3-gene signal is believed to be independent of the prognostic signal identified and is specific for FTI treatment in that patient cluster. As a result, we propose that prognostic signals can be used with drug-specific signals (eg, Tipifarnib prognosis profile) to better manage patient therapy.

Example 6

Identification of differentially expressed genes between responders and non-responders (excluding stable disease patients)

Four patients were classified as having stable disease and these patients were removed from the analysis because they cannot be clearly defined as responders or non-responders. Inclusion of stable disease patients can tilt the analysis to select genes related to prognosis regardless of medication. This compared 10 responders with 44 non-responders. The genes selected were required to exhibit 40% specificity and a minimum mean fold change of 2.0. These criteria were selected to identify the genes that would predict the response to Tipifarnib with the maximum sensitivity possible. From 11,723 genes, a total of eight genes were identified that can stratify responders and non-responders (Table 5) and provide significant P values in the t-test (P <0.05). Genes included therein have been included in signal transduction, apoptosis, cell proliferation, oncogenesis, and potentially in FTI biology. AKAP13 is the most robust marker.

We then aimed to identify the minimum set of genes that provide the best diagnostic accuracy from the eight selected genes. Classifiers were prepared using increasing numbers of genes based on AUC values from characterization of the recipient operating curves, and the error rates of these classifiers were calculated using LOOCV while maintaining the sensitivity of the response predicted at 100% ( 12a). The AKAP13 gene can predict the response with the lowest error rate of less than 40% (FIG. 12A). This error rate increased by more than 50% when two or more genes were used in the classifier. LOOCV for AKAP13 demonstrated 93% NPV and 31% PPV, 63% total diagnostic accuracy, and a positive trend ratio of 2.0 (FIG. 12B). Expression values for AKAP13 in each patient are shown in FIG. 12C. Thus, for the group of patients with low expression of AKAP13, the response rate to Tipiparnib was 31% (8/26) compared to 18% (10/54) in the current patient cluster. Kaplan-Meier analysis, using the AKAP13 gene, showed a significant difference in survival between the predicted and non-responder groups (FIG. 12D).

AUC = area under the curve from recipient operating characterization. This is an indicator of total diagnostic accuracy.

Example 7

Tipifarnib (Zarnestra) in newly diagnosed acute myeloid leukemia patients ^®  R115777) Gene Expression Profiling as a Predictor of Response

Tipifarnib (Zarnestra ^® R115777) demonstrated clinical response in patients with hematological diseases. While inhibition of protein farnesylation is the main mechanism of action (MOA), the level of farnesyl inhibition is not a reliable pharmacodynamic marker of response, and it is not clear which genetic markers can be used to predict the response. These potentially designed studies have been performed to identify potent genetic markers and expression signals that may be surrogate predictors of response to Tipiparnib in acute myeloid leukemia (AML) patients. Bone marrow samples were collected and gene expression profiles were analyzed from single arm stage 2 clinical studies of Tipifarnib in poor-risk patients with newly diagnosed AML. Lancet et al. (2004)]. A total of 79 samples were profiled prior to tipiparnib treatment (n = 25), during treatment (n = 30) and after treatment (n24).

Bone marrow samples were analyzed using Affymetrix U133A GeneChip ^® Arrays. Total gene expression signal indicates that Tipiparnib treatment resulted in a change in gene expression maintained for up to 120 days after the end of treatment. The pre- and post-treatment samples included several genes associated with farnesylation (eg K-ras, FNTA), resulting in significant changes in gene expression following inhibition of farnesyl transferase (false discovery rate [FDR] <0.005). Approximately 500 genes were identified. Many regulated genes have been found to be significantly involved in protein biosynthesis, DNA replication, intracellular signal transduction, and cell cycle pathways, thus reflecting cell proliferation inhibition. A subset of 27 genes (including those associated with signal transduction and cell cycle) were also found to be differentially implicated between responders and non-responders (P <0.01). Gene expression signals that have already been identified from stage 2 clinical trials in relapsed and refractory AML were also tested in pretreatment samples to test their ability to predict response. Raponi et al. (2004)]. The combination of six genes was found to have significant predictive accuracy in these independent sets of samples (P = 0.05). The genes identified from these studies can be used as surrogate biomarkers of Tipifarnib activity.

Patient sample

In phase 2 studies, newly diagnosed AML patients were given Zarnestra ^® , 600 mg bid21dQ4wks. Bone marrow samples were obtained before, during and after treatment with Zarnestra ^® . Monocytes were separated by Ficoll-Hypaque density centrifugation and viable frozen.

Microarray Analysis

Messenger RNA was hybridized to Affymetrix U133 chip, which can be amplified from patient parental cells and probed for approximately 22,000 genes (FIG. 13). Chip data was pre-filtered to remove genes that were not expressed in poor quality data and at least 10% of patient samples. In addition, genes that did not change along the dataset were also removed (CV <40%). Approximately 8000 genes remain for further analysis. A total of 79 chips passed quality control measurements and also had relevant clinical response data.

Statistical analysis

Analysis of changes (ANOVA) and t-tests were used to test the effects of drug treatment and time and their interactions on each gene. Many hypothesis tests were adjusted by applying a false discovery rate (FDR) algorithm. All statistical analyzes were performed in S-Plus 6.1 (Insightful Corporation). Basic component analysis was performed in Partek Pro. Systematic clustering was performed using correlation metric and complete linkage (OmniViz Pro ™, Omnibiz, MA, MAD). Route analysis was performed using Gene Ontology functional classification. Table 6 shows the analysis results.

Approximately 8000 genes were used for clustering under total unsupervision. Treatment samples clustered away from the sample during and after treatment. Post-treatment samples included those from the patient up to 120 days after the end of treatment. FIG. 14 shows that AML samples maintain FTI-mediated total gene expression changes after the end of Tipifarnib treatment.

502 genes were found to be differentially expressed after treatment with Tipifarnib (p <0.005). These genes are listed in Tables 7A-7C and described in more detail in Table 9.

The list includes many genes involved in FTI biology, including AKT1, CENPF, KRAS, RAF1, STAT and farnesyltransferases. Several gene categories were found to be significantly rich in this gene list (Table 8).

Applicants have already identified eight genes that are predictive of resistance to tipiparnib in relapsed and refractory AML. The most predictive gene in this dataset is AKAP-13 (AUC = 0.83)

Predictive values of this gene were tested in the current set of newly diagnosed AML samples (CTEP20). Samples of patients with complete response or progressive disease were used. The results are shown in FIG.

Since the top six genes gave an error rate of less than 50% in the training set, predictive classifiers were constructed from these top six genes. These six classifiers are shown in Table 9 and their ability to stratify newly diagnosed AML is shown in FIG. 16.

conclusion

27% of clinical bone marrow samples may be used, indicating that optimization of sample collection is required.

Total gene expression signal of AML cells showed that FTI-treatment resulted in stable gene expression changes after treatment termination.

Approximately 500 genes (p <0.005) were affected by Tipifarnib, reflecting a number of pathways targeted by FTI. These included many pathways already associated with FTI biology.

Differential expression of 27 genes was found between responders and non-responders after treatment with Tipifarnib (Table 8). These are candidate PD markers.

Six-gene classifiers identified in relapsed and refractory AML were found to have predicted values in newly diagnosed AML.

Example 8

Antibody (predictive)

LBC oncogene-derived peptides were synthesized, coupled to keyhole limpet hemocyanin and used to immunize rabbits for the production of polyclonal antibodies. Serum is tested for responsiveness to the corresponding peptide using ELISA and positive batches are affinity-purified. Purified antibodies specifically detect peptides with epitopes in tissue sections. This is evidenced by complete disappearance of the signal when the corresponding peptide is added simultaneously with the antibody. In addition to these polyclonal antibodies that are very effective in IHC, monoclonal antibodies are produced that can detect proteins in their native folding state. To produce monoclonal antibodies, purified antigens produced in mammalian cells that ensure natural folding and post-translational modifications are generated. The antigen, LBC tumor protein-IgG constant portion fusion protein is expressed in mouse bone marrow cells and the protein is purified using the Fc portion as a handout. This purified antigen is recognized in Western blot by C-terminal polyclonal antibody. Mouse monoclonal antibodies against LBC peptides are generated by selecting from a positive clone a clone that produces an antibody that reacts against an LBC peptide instead of an IgG constant portion using an antigen. Kits for clinical identification of LBC oncogenes can be readily prepared using these and similar antibodies. The kits are commonly used for antibodies directed against LBC peptide identification (and therefore LBC oncogenes), appropriate indicator reagents (e.g. enzymes, labels, etc.), and (optionally) dilution buffers, stabilizers, and such assays. And other reagents useful in clinical applications of such kits, such as other agents.

Example 9

Immunohistochemistry (predictive)

Affinity-purified polyclonal antibodies to the C-terminal peptide of the LBC oncogene are used for IHC detection and localization of the LBC oncogene. 5 μm sections from formalin-fixed and paraffin-embedded normal and tumor tissues were treated with 3-aminopropyl-triethoxy-silane [APES); Sigma, St. Louis, Missouri]. Sections are deparaffinized and rehydrated in graded concentrations of ethanol and treated with methanolic peroxide (0.5% hydrogen peroxide in anhydrous methanol) at room temperature for 30 minutes to block endogenous peroxidase activity. Antigen recovery is performed twice (650 W) for 5 minutes in a microwave oven. Elite ABC kit (Vectastain); Vector Laboratories, Burlin Game, Calif., Is used for immunoperoxidase staining. LBC peptide antibodies are used at an optimal dilution of 1: 2000. Both the biotinylated second antibody and the peroxidase-labeled avidin-biotin complex are incubated on sections for 30 minutes. Dilution is carried out in PBS (pH 7.2) and all incubations are carried out at room temperature in a wet chamber. Slides are washed three times with PBS between different staining steps. Peroxidase staining is visualized using a 3-amino-9-ethylcarbazole (Sigma manufacturer) solution (0.2 mg / ml in 0.05 M acetate buffer containing 0.03% hydrogen peroxide, pH 5.0) at room temperature for 15 minutes. Finally, the sections are slightly counterstained with Myers haematocillin and sealed with an aqueous inclusion medium (Aquamount, BDH). In the control test, the primary antibody was replaced with IgG fragments of normal rabbit serum, or the primary antibody was presorbed with LBC peptide. These stains indicate the presence of LBC oncogenes in a subset of cells.

Although the foregoing invention has been described in detail and by way of example for purposes of clarity of understanding, the description and examples should not be construed as limiting the scope of the invention.

Reference List

<110> Veridex, LLC <120> Methods for assessing patients with acute myeloid leukemia <130> VDX5008WOPCT <150> US 60 / 637,265 <151> 2004-12-17 <150> US 60 / 670,116 <151> 2005-04-11 <150> US 60 / 741,180 <151> 2005-12-01 <160> 705 <170> KopatentIn 1.71 Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtcagatgt ttgccaagga a 21 <212> Type: DNA <211> Length: 21       SequenceName: # 1       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcttcagaaa cacactccca tcac 24 <212> Type: DNA <211> Length: 24       SequenceName: # 2       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgaaacggaa gaagcttgta 20 <212> Type: DNA <211> Length: 20       SequenceName: # 3       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcggcttgtg cagcaatggc caagatcaag gctcgagatc ttcgcgggaa gaagaaggag 60 gagctgctga aacagctgga cgacctgaag gtggagctgt cccagctgcg cgtcgccaaa 120 gtgacaggcg gtgcggcctc caagctctct aagatccgag tcgtccggaa atccattgcc 180 cgtgttctca cagttattaa ccagactcag aaagaaa 217 <212> Type: DNA <211> Length: 217       SequenceName: # 4       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctcgctgta agcagctcat ctgtgacccc agctacgtaa aagatcgggt agaaaaagtg 60 ggccaggtga tcagagttat ttgcatcctc agccacccca tcaagaacac caatgatgcc 120 aactcctgcc agatcattat tccacagaac caagtcaatc gaaagtcaga tatctacgtc 180 tgcatgatct cctttgcgca caatgtagca gcacaaggga agtacattgc tatagttagt 240 acaactgtgg aaaccaagga gcctgagaag gaaatcagac cagctttgga gctcttggaa 300 ccaattgaac agaaatttgt tagcatcagt gacctcctgg taccaaaaga cttgggaaca 360 gaaagccaga tctttatttc ccgcacatat gatgccacca ctcattttga gac 413 <212> Type: DNA <211> Length: 413       SequenceName: # 5       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgaaaagga gaaccccatg cgggaacttc gcatccgcaa actctgtctc aacatctgtg 60 ttggggagag tggaggcaga ctgacgcgag cagccaaggt gttggagcag ctcacagggc 120 agacccctgt gttttccaaa gctagataca ctgtcagatc ctttggcatc cggagaaatg 180 aaaagattgc tgtccactgc gcagttcgag gggccaaggc agaagaaatc ttggagaagg 240 gtctaaaggt gcgggagttg gagttaagaa aaaacaactt ctcagatact ggaaactttg 300 gttttgggat ccaggaacac attgatctgg gtatcgaata tgacccaagc attggtatct 360 acggcctgga 370 <212> Type: DNA <211> Length: 370       SequenceName: # 6       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atcttttgtc tttccgtgga gctgtcgcca tgaaggtcga gctgtgcagt tttagcgggt 60 acaagatcta ccccggacac gggaggcgct acgccaggac cgacgggaag gttttccagt 120 ttcttaatgc gaaatgcgag tcggctttcc tttccaagag gaatcctcgg cagataaact 180 ggactgtcct ctacagaagg aagcacaaaa agggacagtc ggaagaaatt caaaagaaaa 240 gaacccgccg agcagtcaaa ttccagaggg ccattactgg tgcatctctt gctgatataa 300 tggccaagag gaatcagaaa cctgaagtta gaaaggctca acgagaacaa gctatcaggg 360 ctgct 365 <212> Type: DNA <211> Length: 365       SequenceName: # 7       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcggtggagc cgcaaccaaa atgcagattt tcgtgaaaac ccttacgggg aagaccatca 60 ccctcgaggt tgaaccctcg gatacgatag aaaatgtaaa ggccaagatc caggataagg 120 aaggaattcc tcctgatcag cagagactga tctttgctgg caagcagcta gaagatggac 180 gtactttgtc tgactacaat attcaaaagg agtctactct tcatcttgtg ttgagacttc 240 gtggtggtgc taagaaaagg aagaagaagt cttacaccac tcccaagaag aataagcaca 300 agagaaagaa ggttaagctg gctgtcctga aatattataa ggtggatgag aatggcaaaa 360 ttagtcgcct tcgtcgagag tgcccttctg atgaatgtgg tgctggggtg tttatggcaa 420 gtcactttga cagacattat tgtggcaaat gttgtctgac ttactgtttc aacaaaccag 480 a 481 <212> Type: DNA <211> Length: 481       SequenceName: # 8       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccatcatgg gtcgcatgca tgctcccggg aagggcctgt cccagtcggc tttaccctat 60 cgacgcagcg tccccacttg gttgaagttg acatctgacg acgtgaagga gcagatttac 120 aaactggcca agaagggcct tactccttca cagatcggtg taatcctgag agattcacat 180 ggtgttgcac aagtacgttt tgtgacaggc aataaaattt taagaattct taagtctaag 240 ggacttgctc ctgatcttcc tgaagatctc taccatttaa ttaagaaagc agttgctgtt 300 cgaaagcatc ttgagaggaa cagaaaggat aaggatgcta aattccgtct gattctaata 360 gagagccgga ttcaccgttt ggctcgatat tataagacca agcgagtcct ccctcccaat 420 tggaaatatg aatcatctac agcctctgcc ctggtcgcat aaatttg 467 <212> Type: DNA <211> Length: 467       SequenceName: # 9       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttgatgatgg cacctcagat cgcccctaca gccatgctct ggtggctgga attgaccgct 60 acccccgcaa agtgacagct gccatgggca agaagaagat cgccaagaga tcaaagataa 120 aatcttttgt gaaagtgtat aactacaatc acctaatgcc cacaaggtac tctgtggata 180 tccccttgga caaaactgtc gtcaataagg atgtcttcag agatcctgct cttaaacgca 240 aggcccgacg ggaggccaag gtcaagtttg aagagagata caagacaggc aagaacaagt 300 ggttcttcca gaaactgcgg ttttagatgc tttgt 335 <212> Type: DNA <211> Length: 335       SequenceName: # 10       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgcaggcact cagaatggtc cagcgtttga cataccgacg taggctttcc tacaatacag 60 cctctaacaa aactaggctg tcccgaaccc ctggtaatag aattgtttac ctttatacca 120 agaaggttgg gaaagcacca aaatctgcat gtggtgtgtg cccaggcaaa cttcgagggg 180 ttcgtcctgt aagacctaaa gttcttatga gattgtccaa aacaaagaaa catgtcagca 240 gggcctatgg tggttccatg tgtgctaaat gtgttcgtga caggatcaag cgtgctttcc 300 tta 303 <212> Type: DNA <211> Length: 303       SequenceName: # 11       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaggctttc tcggtatcag cagtttaaag attttcaacg acgaattctt gtggctacca 60 acctatttgg ccgaggcatg gacatcgagc gggtgaacat tgcttttaat tatgacatgc 120 ctgaggattc tgacacctac ctgcatcggg tggccagagc aggccggttt ggcaccaagg 180 gcttggctat cacatttgtg tccgatgaga atgatgccaa gatcctcaat gatgtgcagg 240 atcgctttga ggtcaatatt agtgagctgc ctgatgagat agacatctcc tcctacattg 300 aacagacacg gtagaagact cgcccatttt ggaatgtg 338 <212> Type: DNA <211> Length: 338       SequenceName: # 12       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtggggat ggtcgagtat ctcagaaaag aagacatgga atatgccctg cgtaaactgg 60 atgacaccaa attccgctct catgagggtg aaacttccta catccgagtt tatcctgaga 120 gaagcaccag ctatggctac tcacggtctc ggtctgggtc aaggggccgt gactctccat 180 accaaagcag gggttcccca cactacttct ctcctttcag gccctactga gacaggtgat 240 gggaattttt tctttatttt ttaggttaac tgagctgctt tgtgctcaga atctacattc 300 cagattgagg atttagtgtc ttaggaaatt tttttaattt ttttttttta aagaagaaaa 360 aaaactacat aatttctacc agggccatat tagcagtgaa acattttaaa ctgcagaaat 420 tgtggttttg gttcagaaac aagttgtata tttttcaccc ctgattatgg gaaaaaatcg 480 ttctgtcttt gtggggttcg ctctactatg gagatcaaca gttactgtga ctgagtcggc 540 ccattc 546 <212> Type: DNA <211> Length: 546       SequenceName: # 13       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatgaagagg gtagagtggg ctgctggtgt cgcatcaaga tttggcagga tcggcttcct 60 caggggcaca gacctctccc acccacaaga actcctccca cccaacttcc ccttagagtg 120 ctgtgagatg agagtgggta aatcagggac agggccatgg ggtagggtga gaagggcagg 180 ggtgtcctga tgcaaaggtg gggagaaggg atcctaatcc cttcctctcc cattcaccct 240 gtgtaacagg accccaagga cctgcctccc cggaagtgcc ttaacctaga gggtcgggga 300 ggaggttgtg tcactgactc aggctgctcc ttctctagtt tcccctctca tctgacctta 360 gtttgctgcc atcagtctag tggtttcgt 389 <212> Type: DNA <211> Length: 389       SequenceName: # 14       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agatcgccat catgaacgac accgtaacta tccgcactag aaagttcatg accaaccgac 60 tacttcagag gaaacaaatg gtcattgatg tccttcaccc cgggaaggcg acagtgccta 120 agacagaaat tcgggaaaaa ctagccaaaa tgtacaagac cacaccggat gtcatctttg 180 tatttggatt cagaactcat tttggtggtg gcaagacaac tggctttggc atgatttatg 240 attccctgga ttatgcaaag aaaaatgaac ccaaacatag acttgcaaga catggcctgt 300 atgagaagaa aaagacctca agaaagcaac gaaaggaacg caagaacaga atgaagaaag 360 tcagggggac tgcaaaggcc aatgttggtg ctggcaaaaa gtgagctgga gattggatca 420 cagccgaagg agtaaaggtg ctgcaatgat gttagctgtg gccactgtgg atttttcgca 480 aga 483 <212> Type: DNA <211> Length: 483       SequenceName: # 15       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaagagctc gtggaagagg tggtgaccag cagagtggtt atgggaaggt atccagggca 60 ggtggtcatc aaaatagcta caaaccatat ctaaattatt ccatttgcaa cttatcccca 120 acaggtggtg aagcagtatt ttccaatttg aagattcatt tgaatggctc ctgccacctg 180 ctaatagcag ttcaaactaa attttttgta tcaagtccct gaatggaagt atgacgttgg 240 gtccctctga agtttaattc tgagttctca ttaaaagaaa tttgctttca ttgttttatt 300 <212> Type: DNA <211> Length: 300       SequenceName: # 16       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagcgaagac ttttcgctcc cagcttatat ggatcggcgt gaccacccct tgccggagnt 60 ggccnnatgt caagcacctg tctgccagcc agaaggcact gaaggagaag gagaaggcct 120 cctggagcag cctctccatg gatgagaaag tcgagttgta tcgcattaag ttcaaggaga 180 gctttgctga gatgaacagg ggctcgaacg agtggaagac ggttgtggnc ggtgccatgt 240 tcttcatcgg tttcaccgcg ctcgttatca tgtggcagaa gcactatgtg tacggccccc 300 tcccgcaaag ctttgacaaa gagtgggtgg ccaagcagac caagaggatg ctggacatga 360 aggtgaaccc catccagggc ttagcctcca agtgggacta cgaaaagaac gagtggaaga 420 agtgagagat gctgncctgc gcctgcacct gcgcctggct ctgtcaccgc catgcaactc 480 catgcctatt tactggaaac ctgttatgcc aaacagttgt accactgcta ataaatgacc 540 <212> Type: DNA <211> Length: 540       SequenceName: # 17       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggtactgac catcagtgtc agcattaggg ttttggtttt tgtttctttt gggtatttct 60 tttttggcac atgtgaatct tgttttgtgt aaaatgaaat tactttctct tgttctctga 120 tgatgggttt aaaattaaaa gagcatccgg ttttggtatg gggatgatcc aggattatgt 180 tgtgactgat acatattagt tacttgtgct tttttttttt ttttttngga tctttgcaag 240 ggcaaaacta caagtaacga gttttatata attaatttaa atttgttaca ggttttcatg 300 ttcaggataa accatacttc caccttgggt gagaacactt gcaacagttt attaatgagg 360 tgactttcac cttaggacaa ctgttgcatg ccaagttttt tgtgtgtgtg aaacacttca 420 aaactgattt aaaagatgta aatttaaaat tggttgtatc taatatgccc cagg 474 <212> Type: DNA <211> Length: 474       SequenceName: # 18       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccgcctaag gacgacaaga agaagaagga cgctggaaag tcggccaaga aagacaaaga 60 cccagtgaac aaatccgggg gcaaggccaa aaagaagaag tggtccaaag gcaaagttcg 120 ggacaagctc aataacttag tcttgtttga caaagctacc tatgataaac tctgtaagga 180 agttcccaac tataaactta taaccccagc tgtggtctct gagagactga agattcgagg 240 ctccctggcc agggcagccc ttcaggagct ccttagtaaa ggacttatca aactggtttc 300 aaagcacaga gctcaagtaa tttacaccag aaataccaag ggtggagatg ctccagctgc 360 tggtgaagat gcatgaatag gtccaaccag ctgta 395 <212> Type: DNA <211> Length: 395       SequenceName: # 19       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaaacgttc gtcaacatca cgccagctga ggtgggtgtc ctggttggca aagaccggtc 60 aagtttttac gtgaatgggc tgacacttgg gggccagaaa tgttcggtga tccgggactc 120 actgctgcag gatggggaat ttagcatgga tcttcgtacc aagagcaccg gtggggcccc 180 caccttcaat gtcactgtca ccaagactga caagacgcta gtcctgctga tgggcaaaga 240 aggtgtccac ggtggtttga tcaacaagaa atgttatgaa atggcctccc accttcggcg 300 ttcccagtac tgacctcgtc tgtcccttcc ccttcaccgc tccccacagc tttgcacccc 360 tttcctcccc atacacacac aaaccatttt attttttggg ccattacccc atacccctta 420 ttgctgccaa aaccacatg 439 <212> Type: DNA <211> Length: 439       SequenceName: # 20       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atactcttat agcctgcctt caattttgat cctttattct ttctatttgt caggtgcaca 60 agattacctt cctgttttag ccttctgtct tgtcaccaac cattcttact tggtggccat 120 gtacttggaa aaaggccgca tgatctttct ggctccactc agtgtctaag gcaccctgct 180 tcctttgctt gcatcccaca gactatttcc ctcatcctat ttactgcagc aaatctctcc 240 ttagttgatg agactgtgtt tatctccctt t 271 <212> Type: DNA <211> Length: 271       SequenceName: # 21       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaggtatac atgaaacccc cagcacacga agaggccaag gcaccttcca gaggctttgt 60 ggtgcgggac gcaccctgga ccgccagcag cagtgagaag gctcctgaca tgagcagctc 120 tgaggaattt cccagctttg gggctcaggt ggctcccaag accctccctt ggggccccaa 180 acgataatga tcaaaaagaa cagaaccctc tccagcctgc tgacccgaac ccaaccacac 240 aatggtttgt ctcaatctga cccagcggct ggaccctccg taaattgttg agcgctcttc 300 ccc 303 <212> Type: DNA <211> Length: 303       SequenceName: # 22       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtggtttg tggattccct caaccagaag atggaggtgc agcgccggcc ctggttagtg 60 aagtacgggg acagcgggga gcagattgcc ggcttcgtga aggagttctc ccacatcgcc 120 tttctcacga tcaagggcgc cggccacatg gttcccaccg acaagcccct cgctgccttc 180 accatgttct cccgcttcct gaacaagcag ccatactgat gaccacagca accagctcca 240 cggcctgatg cagcccctcc cagcctctcc cgctaggaga gtcctcttct aagcaaagtg 300 cccctgcagg cgggttctgc cgccaggact gcccccttcc cagagccctg tacatcccag 360 actgggccca gggtctccca tagacagcct gggggcaagt tagcacttta ttcccgcagc 420 agttcctgaa tggggtggcc tggccccttc tctgcttaaa gaatgccctt tatgatgcac 480 tgattccatc ccaggaaccc aacagagctc agga 514 <212> Type: DNA <211> Length: 514       SequenceName: # 23       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa ttgttaatat 60 tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat attgtcctca 120 ttgcatgtgt agtttngagc acagagtccc aaaccttacg gccaagtttc ttctagtatg 180 atgg 184 <212> Type: DNA <211> Length: 184       SequenceName: # 24       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaaagccat ctttgcattg ttcctcatcc gncctccttg ctcngccgca gccgcctccg 60 ccgcgcgcct cctccgccgc cgcggactnc cggcagcttt atcgccagag tccctgaact 120 ctcgctttct ttttaatccc cntgcatcgg atcaccggcg tgccccacca tgtcagacgc 180 agccgtagac accagctccg aaatcaccac caaggactta aaggagaaga aggaagttgt 240 ggaagaggca gaaanatgga agaganncgc ccctgctnaa cgggnaatgc tnnananant 300 gaggaanaat ggggnagcag gaggctngac aatngaggta gacgaangaa ganggaagan 360 anggtgggga nggaangagg anggaggana gaangaaggt gantggtgan ggaangagga 420 ntggangant gaangatgag gaagctgagt cagctacggg caagcgggca gctgaangat 480 gatgaggatg acgatgtcga taccaangaa gcagaagacc gacgaggatg actagacagc 540 <212> Type: DNA <211> Length: 540       SequenceName: # 25       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctcgctacac tactcctgag gatgctactc ccgagcccgg agaggaccca cgcgtgaccc 60 gggccaagta cttcattcga gatgagtttc tgaggatcag cactgccagt ggagatgggc 120 gtcactactg ctaccctcat ttcacctgcg ctgtggacac tgagaacatc cgccgtgtgt 180 tcaacgactg ccgtgacatc attcagcgca tgcaccttcg tcagtacgag ctgctctaag 240 aagggaaccc ccaaatttaa ttaaagcctt aagcacaatt aattaaaagt gaaacgtaat 300 tgtacaagca gttaatcacc caccataggg catgattaac aaagcaacct ttcccttccc 360 ccgagtgatt ttgcgaaacc cccttttccc ttcagcttgc ttagatgttc caaatttaga 420 aagcttaagg cggcctacag aaaaaggaaa aaaggccaca aaagttccct ctcactttca 480 gtaaaaat 488 <212> Type: DNA <211> Length: 488       SequenceName: # 26       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatgacttag ttgcgttaca ccctttcttg acaaaaccta acttgcgcag aaaacaagat 60 gagattggca tggctttatt tgtttttttt gttttgtttt ggtttttttt ttttttttgg 120 cttgactcag gatttaaaaa ctggaacggt gaaggtgaca gcagtcggtt ggagcgagca 180 tcccccaaag ttcacaatgt ggccgaggac tttgattgca cattgttgtt tttttaatag 240 tcattccaaa tatgagatgc attgttacag gaagtccctt gccatcctaa aagccacccc 300 acttctctct aaggagaatg gcccagtcct ctcccaagtc cacacagggg aggtgatagc 360 attgctttcg tgtaaattat gtaatgcaaa atttttttaa tcttcgcctt aatacttttt 420 tattttgttt tattttgaat gatgagcctt cgtgcccccc cttccccctt tttgtccccc 480 aacttgagat gtatgaaggc ttttggtctc cctgggagtg ggtggaggca gccagggctt 540 acctgtacac tgact 555 <212> Type: DNA <211> Length: 555       SequenceName: # 27       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcctcgaaa tgcagaacga cgccggcgag ttcgtggacc tgtacgtgcc gcggaaatgc 60 tccgctagca atcgcatcat cggtgccaag gaccacgcat ccatccagat gaacgtggcc 120 gaggttgaca aggtcacagg caggtttaat ggccagttta aaacttatgc tatctgcggg 180 gccattcgta ggatgggtga gtcagatgat tccattctcc gat 223 <212> Type: DNA <211> Length: 223       SequenceName: # 28       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agctcccaac tactgtggcg agtttgacaa tgctggcgcc atgatgagtg tggacgagac 60 cctcatgtgc tctttccaga tcctcaagcc cgccgacaag aacaagggga agtacgggca 120 gttcagtggc ctgaaccctg gaggccgacc catcacccca ccccgcaatt ccgccaaagc 180 caagaaatag cccccgcaca ccaccctgtg ccccagatga tggattgatt gtacagaaat 240 catgctgcca tgctgggggg gggtcacccc gacccctaag gcccacctgt cacggggaac 300 atggagcctt ggtgtatttt tcttttcttt ttttaatgaa tcaatagcag cgtccagtcc 360 cccagggctg cttcctgcct gcacctgcgg tactgtgagc aggatcctgg g 411 <212> Type: DNA <211> Length: 411       SequenceName: # 29       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acctcaccgc agaggtactt gaactggcag gaaatgcatc aaaagactta aaggtaaagc 60 gtattacccc tcgtcacttg caacttgcta ttcgtggaga tgaagaattg gattctctca 120 tcaaggctac aattgctggt ggtggtgtca ttccacacat ccacaaatct ctgattggga 180 agaaaggaca acagaagact gtctaaagga tgcctggatt ccttgttatc tcaggactct 240 aaatactcta acagctgtcc agtgttggtg attccagtgg actgtatctc tgtgaaaaac 300 acaattttgc ctttttgtaa ttctatttga gcaagttgga agtttaatta gctttccaac 360 caaccaaatt tctgcattcg agtcttaacc atatttaagt gttactgtgg cttcaaagaa 420 gctattgatt ctgaagtagt gggttttgat tgagttgact gtttttaaaa aactgtttgg 480 attttaattg tgatgcagaa gttatagtaa caaacatttg gttttgttca gaccttattt 540 ccact 545 <212> Type: DNA <211> Length: 545       SequenceName: # 30       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcctgggaag acaggccctc ttcaacaggc tcaactcagt ttccttataa ccctctgact 60 atgcggatgc tcagcagtac tccaccaaca ccgattgcat gtgctccctc tgcggtgaac 120 caagcagctc ctcaccaaca gaacaggatc tgggagcgag agcctgcccc actgctctca 180 gcacagtacg agaccctgtc ggatagtgat gactgaactg cacaaagtga ggggaacagg 240 gtgcaggaga gggatctcta gtttttgtgg tttaattttt agtagcaggt caaaaacctg 300 ccctcctgtg acttattccc tgagactttt caggagagcc agcccacaga tgatgaagaa 360 atgatggaag ttcatttgga gagtcaaatg ggaaaaaaac aaacaaaaaa ctgcctttga 420 tacaggcaat tcagtggact ataataatag tggagggttg agatgtagag tttttaaaaa 480 gtgaacagtt gctgttctta catctgta 508 <212> Type: DNA <211> Length: 508       SequenceName: # 31       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acacagtccg tgtgcgggga ggtaacaaga aataccgtgc cctgaggttg gacgtgggga 60 atttctcctg gggctcagag tgttgtactc gtaaaacaag gatcatcgat gttgtctaca 120 atgcatctaa taacgagctg gttcgtacca agaccctggt gaagaattgc atcgtgctca 180 tcgacagcac accgtaccga cagtggtacg agtcccacta tgcgctgccc ctgggccgca 240 agaagggagc caagctgac 259 <212> Type: DNA <211> Length: 259       SequenceName: # 32       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgatatcta aggagttggc aagcttaaca aaacccattt tttataaatg tccatcctcc 60 tgcatttgtt gataccacta acaaaatgct ttgtaacaga cttgcggtta attatgcaaa 120 tgatagtttg tgataattgg tccagtttta cgaacaacag atttctaaat tagagaggtt 180 aacaagacag atgattacta tgcctcatgt gctgtgtgct ctttgaaagg aatgacagca 240 gactacaaag caaataagat atactgagcc tcaacagatt gcctgctcct cagagtctct 300 cctatttttg tattacccag ctttcttttt aatacaaatg ttatttatag tttacaatga 360 atgcactgca taaaaacttt gtagcttcat tattgtaaaa catattcaag atcctacagt 420 aagagtgaaa cattcacaaa gatttgcgtt aatgaagact acacagaaaa cctttctagg 480 gatttgtgtg gatcagatac atacttggca aatttttgag ttttacattc ttacagaa 538 <212> Type: DNA <211> Length: 538       SequenceName: # 33       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtggtagt tggtgtgtcc tcggtttctc ggctgctggg tcggtcccgc ccacagctgg 60 ggcggcctat gtcgagtggc gcccatggcg aagagggctc agctcgcatg tggaagactc 120 tcaccttctt cgtcgcgctc cccggggtgg cagtcagcat gctgaatgtg tacctgaagt 180 cgcaccacgg agagcacgag agacccgagt tcatcgccta cccccatctc cgcatcagga 240 ccaagccgtt tccctgggga gatggtaacc atactctatt ccataaccct catgtgaatc 300 cacttccaac tggctacgaa gatgaataaa gagaatctgg accactaccc gggcaccagg 360 gaccacagca ctggtttgga ccgttactct gcacatggac cagaaaaagt atatgggacc 420 ttaagctaac cttctttact tgtatcaaat gatgactggt atactggtct cccatc 476 <212> Type: DNA <211> Length: 476       SequenceName: # 34       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatttttatt aactgctttt gcccatataa aatgctgata tttactggaa acctagccag 60 cttcacgatt atgactaaag taccagatta taatgccaga atataatgtg caggcaatcg 120 tggatgtctc tgacaaagtg tgtctcaaaa ataatatact tttacattaa agaaatttaa 180 tgtttctctg gagttggggc tcttggcttt cagagtttgg ttaatcagtg ttgattctag 240 atgatcaaca taatggacca ctcctgaatg agacttaatt ttgtctttca aatttactgt 300 cttaaatcag tttattaaat ctgaatttta aaacatgctg tttatgacac aatgacacat 360 ttgttgcacc aattaagtgt tgaaaaatat ctttgcatca tagaacagaa atatataaaa 420 atatatgttg aatgttaaca ggtattttca caggtttgtt tcttgatagt tactcagaca 480 ctagggaaag gtaaatacaa gtgaacaaaa taagcaacta aatgagacct aataattggc 540 cttcgatt 548 <212> Type: DNA <211> Length: 548       SequenceName: # 35       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacgcggtcg taagggctga ggatttttgg tccgcacgct cctgctcctg actcaccgct 60 gttcgctctc gccgaggaac aagtcggtca ggaagcccgc gcgcaacagc catggctttt 120 aaggataccg gaaaaacacc cgtggagccg gaggtggcaa ttcaccgaat tcgaatcacc 180 ctaacaagcc gcaacgtaaa atccttggaa aaggtgtgtg ctgacttgat aagaggcgca 240 aaagaaaaga atctcaaagt gaaaggacca gttcgaatgc ctaccaagac tttgagaatc 300 actacaagaa aaactccttg tggtgaaggt tctaagacgt gggatcgttt ccagatgaga 360 attcacaagc gactcattga cttgcacagt ccttctgaga ttgttaagca gattacttcc 420 atcagtattg agccaggagt tgaggtggaa gtcaccattg cagatgctt 469 <212> Type: DNA <211> Length: 469       SequenceName: # 36       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggacattgtg ggatcgcttt gaggtacaag ggctgcagcc taatggtgag gagatgaccc 60 tcaaacagtt cctcgactat tttaagacag agcacaaatt agagatcacc atgctgtccc 120 agggcgtgtc catgctctat tccttcttca tgccagctgc caagctcaag gaacggttgg 180 atcagccgat gacagagatt gtgagccgtg tgtcgaagcg aaagctgggc cgccacgtgc 240 gggcgctggt gcttgagctg tgctgtaacg acgagagcgg cgaggatgtc gaggttccct 300 atgtccgata caccatccgc tgaccccgtc tgctcctcta ggctggcccc ttgtccaccc 360 ctctccacac cccttccagc ccagggttcc catttggctt ctggcagtgg cccaactagc 420 caagtctggt gttccctc 438 <212> Type: DNA <211> Length: 438       SequenceName: # 37       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggaggcag gcgagtgagc gagtccgagg ggtggccggg gcaggtggtg gcgccgcgaa 60 gatggtcgcc aagcaaagga tccgtatggc caacgagaag cacagcaaga acatcaccca 120 gcgcggcaac gtcgccaaga cctcgagaaa tgcccccgaa gagaaggcgt ctgtaggacc 180 ctggttattg gctctcttca tttttgttgt ctgtggttct gcaattttcc agattattca 240 aagtatcagg atgggcatgt gaagtgactg accttaagat gtttccattc tcctgtgaat 300 ttttaacttg aactcattcc tgatgtttga taccctggtt gaaaacaatt cagtaaagca 360 tcctgcctca gaatgacttt cctatcatgc ttcatgtgtc attccaaggt ttcttcatga 420 gtcattccaa gttttctagt cca 443 <212> Type: DNA <211> Length: 443       SequenceName: # 38       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgggccaag tacttcattc gagatgagtt tctgaggatc agcactgcca gtggagatgg 60 gcgtcactac tgctaccctc atttcacctg cgctgtggac actgagaaca tccgccgtgt 120 gttcaacgac tgccgtgaca tcattcagcg catgcacctt cgtcagtacg agctgctcta 180 agaagggaac ccccaaattt aattaaagcc ttaagcacaa ttaattaaaa gtgaaacgta 240 attgtacaag cagttaatca cccaccatag ggcatgatta acaaagcaac ctttcccttc 300 ccccgagtga ttttgcgaaa cccccttttc ccttcagctt gcttagatgt tccaaattta 360 gaaagcttaa ggcggcctac agaaaaagga aaaaaggcca caaaagttcc ctctcacttt 420 cagtaaaaat 430 <212> Type: DNA <211> Length: 430       SequenceName: # 39       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgccacccgg gagtctatgg tcaaactctc aagtaagctg agtgccgtga gcttgcgggg 60 aattggcagt cccagcacag atgccagtgc cagtgatgtc cacggcaatt tcgccttcga 120 gggcattgga gatgaggatc tgtaatctcc actgcttgga tgtctgccct ctaccccaga 180 ggaatttaca gaaacttgcc ctgtgcctgt gtcccccatg ctaggggcgg aggggtcttt 240 tccttcttct ttcctaccta ccccttttct cttggccagg ggcctcgtat cctacctttc 300 cttgtcccct gggctggctg cacagaggat tgccccttct cttttcagag ctggccctcg 360 atgccaaatt agcat 375 <212> Type: DNA <211> Length: 375       SequenceName: # 40       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgaaaggaat ccgctgcttg agggctgcct ccctcatggt gtgcgtgtcg ttctcttcct 60 gacgcatctg tgatatcaga ggtaactatg caaagcatcc aggcggttct gaatgtgaag 120 cactacaccc agcagagtcc cggtgccctc tgtccccact gccggcccat gtcctctctc 180 cggaggtcac caaggaatgc acaggtttcg actaccagaa aggggagtcc ttgggttctt 240 tcaaaaaatt cgtgaggaga gctgtctaca gtggaatagg gggtctccct ggggaatgca 300 ggccaagtcc ttttatttta acatgatgtc catgaagagg tttgccgtct gggcagccct 360 gtcggcaagg agcgtgcata ctgcgtttgt gtaattgttt gctgtatctc ccttccctct 420 gagctgtatt gttcttta 438 <212> Type: DNA <211> Length: 438       SequenceName: # 41       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acattttaca ttccatcttt tctgaagatt gtcctacaat ttggattttg atcatgacaa 60 agaagattaa aatttcatta gcatgaatgc aatttgttaa agcagactga tttgtttcta 120 agatattttt ggttttttta aaactgataa taatgctgaa ttatcttaag tgagatgtta 180 agcccacttt gttcttttaa tgtaatggag cttatgggta gaagaccatg tctactaatt 240 acaaaaaaaa aaaaaaacca tgattgctgc ttttcctacc acttccagta agaaaatggg 300 tgttttgaag aaatcatttg ccttgtctca cggaatctga ttaagccctg gcctcttgat 360 gtatagagtc atggatattc cagttaccta gatattccct tgagattttg atac 414 <212> Type: DNA <211> Length: 414       SequenceName: # 42       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcacatagc agtatttccc tgcaagataa aaatcctccc tcagtacatt tttaattctc 60 gagatccgat agtgatgggg gtgacggtgg aagcaggtca ggtgaaacag gggacaccca 120 tgtgtgtccc aagcaaaaat tttgttgaca tcggaatagt aacaagtatt gaaataaacc 180 ataaacaagt ggatgttgca aaaaaaggac aagaagtttg tgtaaaaata gaacctatcc 240 ctggtgagtc acccaaaatg tttggaagac attttgaagc tacagatatt cttgttagta 300 agatcagccg gcagtccatt gatgcactca aagactggtt cagagatgaa atgcagaaga 360 gtgactggca gcttattgtg gagctgaaga aagtatttga aatcatctaa ttttttcaca 420 tggagcagga actggagtaa atgcaatact gtgttgtaat atcccaa 467 <212> Type: DNA <211> Length: 467       SequenceName: # 43       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccttcagacc ccagttctag gggagaagag ccctggacac ccctgctcta cccatgagcc 60 tgcccgctgc aatgcctaga cttcccaaca gccttagctg ccagtgctgg tcactaacca 120 acaaggttgg ncaccccagc taccccttct ttgcagggct aaggccccca aacatagccc 180 ctgccccgga ggaagcttgg ggaacccatg agttgtcagc tttgacttta tctcctgctc 240 tttctacatg actgggcctc ccttgggctg gaagaattgg ggattctcta ttggaggtga 300 gatcacagcc tccagggccc cccaaatccc agggaaggac ttggagagaa tcatgctgtt 360 gcatttagaa ctttctgctt tgcacaggaa agagtcacac aattaatcaa catgtatatt 420 ttctctatac atagagctct atttctctac ggtttta 457 <212> Type: DNA <211> Length: 457       SequenceName: # 44       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccatgtctct agtgatccct gaaaagttcc agcatatttt gcgagtactc aacaccaaca 60 ttgatgggcg gcggaaaata gcctttgcca tcactgccat taagggtgtg ggccgaagat 120 atgctcatgt ggtgttgagg aaagcagaca ttgacctcac caagagggcg ggagaactca 180 ctgaggatga ggtggaacgt gtgatcacca ttatgcagaa tccacgccag tacaagatcc 240 cagactggtt cttgaacaga cagaaggatg taaaggatgg aaaatacagc caggtcctag 300 ccaatggtct ggacaacaag ctccgtgaag acctggagcg actgaagaag attcgggccc 360 atagagggct gcgtcac 377 <212> Type: DNA <211> Length: 377       SequenceName: # 45       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttacctcgt tgcactgctg agagcaagat gggtcaccag cagctgtact ggagccaccc 60 gcgaaaattc ggccagggtt ctcgctcttg tcgtgtctgt tcaaaccggc acggtctgat 120 ccggaaatat ggcctcaata tgtgccgcca gtgtttccgt cagtacgcga aggatatcgg 180 tttcattaag ttggactaaa tgctcttcct tcagaggatt atccggggca tctact 236 <212> Type: DNA <211> Length: 236       SequenceName: # 46       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcatgtctc tgagcttcta tacctgctca aggtcattgt catctttgtg tttagctcat 60 ccaaaggtgt taccctggtt tcaatgaacc taacctcatt ctttgtgtct tcagtgttgg 120 cttgttttag ctgatccatc tgtaacacag gagggatcct tggctgagga ttgtatttca 180 gaaccaccaa ctgctcttga caattgttaa cccgctaggc tcctttggtt agagaagcca 240 cagtccttca gcctccaatt ggtgtcagta cttaggaaga ccacagctag atggacaaac 300 agcattggga ggccttagcc ctgctcctct caattccatc ctgtagagaa caggagtcag 360 gagccgctgg caggagacag catgtcaccc aggactctgc cggtgcagaa tatgagcaat 420 gccatgttct tgcagaaaac gcttaacctg agtttcatag gaggtaatca ccagacaact 480 gcagaatgta gaacactgag caggacaact gacctgtctc cttcacatag tccatatca 539 <212> Type: DNA <211> Length: 539       SequenceName: # 47       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttcggaaggc actctacgct tccaagatca tctcttacgc tcaaggcttt atgctgctaa 60 ggcaggcagc caccgagttt ggctggactc tcaattatgg tggcatcgcc ctgatgtgga 120 gagggggctg catcattaga agtgtattcc taggaaagat aaaggatgca tttgatcgaa 180 acccggaact tcagaacctc ctactggacg acttctttaa gtcagctgtt gaaaactgcc 240 aggactcctg gcggcgggca gtcagcactg gggtccaggc tggcattccc atgccctgtt 300 ttaccactgc cctctccttc tatgacgggt acagacatga gatgcttcca gccagcctca 360 tccaggctca gcgggattac ttcggggctc acacctatga actcttggcc aaaccagggc 420 agtttatcca caccaactgg acaggccatg gtggcaccgt gtcatcctcg tcatacaatg 480 cctgatgggc tcctgtcacc ctccacgtct ccacagacca ggacattcca tg 532 <212> Type: DNA <211> Length: 532       SequenceName: # 48       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagcttccag cggctatgtt gggccagagc atccggaggt tcacaacctc tgtggtccgt 60 aggagccact atgaggaggg ccctgggaag aatttgccat tttcagtgga aaacaagtgg 120 tcgttactag ctaagatgtg tttgtacttt ggatctgcat ttgctacacc cttccttgta 180 gtaagacacc aactgcttaa aacataagga tgtttcagtt cctccattta acagatatga 240 agagcatttt aagaggtgca gcctctggaa gtggatcaaa ctagaactca tatgccatac 300 t 301 <212> Type: DNA <211> Length: 301       SequenceName: # 49       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggtgaaggt gccgagctat aaacctccag aatattatta gtctgcatgg ttaaaagtag 60 tcatggataa ctacattacc tgttcttgcc taataagttt cttttaatcc aatccactaa 120 cactttagtt atattcactg gttttacaca gagaaataca aaataaagat cacacatcaa 180 gactatctac aa 192 <212> Type: DNA <211> Length: 192       SequenceName: # 50       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcagaaggta ggggccgtgt cccgcggtgc tgactgaggc ctgcttcccc ctccccctcc 60 tgctgtgctg gaattccaca gggaccaggg ccaccgcagg ggactgtctc agaagacttg 120 atttttccgt ccctttttct ccacactcca ctgacaaacg tccccagcgg tttccacttg 180 tgggcttcag gtgttttcaa gcacaaccca ccacaacaag caagtgcatt ttcagtcgtt 240 gtgctttttt gttttgtgct aacgtcttac taatttaaag atgctgtcgg caccatgttt 300 atttatttcc agtggtcatg ctcagccttg ctgctctgcg tggcgcaggt gccatgcctg 360 ctccctgtct gtgtcccagc cacgcagggc catccactgt gacgtcggcc gaccaggctg 420 gacaccctct gccgagtaat gacgtgtgtg gctgggacct tctttattct gtgttaatgg 480 ctaacctgtt acactgggct gggttgggta gggtgttctg gc 522 <212> Type: DNA <211> Length: 522       SequenceName: # 51       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagcttttc caagtgtgag cgccccaccg acatgtgtgc tgatcagaga ctggagaggt 60 ggagtgagaa gtctccgctg ctcgggccct cctggggagc ccccgctcca gggctcgctc 120 caggaccttc ttcacaagat gacttgctcg ctgttacctg cttccccagt cttttctgaa 180 aaactacaaa ttagggtggg aaaagctctg tattgagaag ggtcatattt gctttctagg 240 aggtttgttg ttttccctgt tagttttgag gagcaggaag ctcatggggg cttctgtagc 300 ccctctcaaa aggagtcttt attctgagaa tttgaagctg aaacctcttt aaatcttcag 360 aatgatttta ttgaagaggg gcgcaagccc caaatggaaa actg 404 <212> Type: DNA <211> Length: 404       SequenceName: # 52       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtatccttac aataatctgt acctggaacg aggcggtgat ccctccaaag aaccagagcg 60 ggtggttcac tatgagatct gaggaggctt cgtgggcttt tgggtcctct aactaggact 120 ccctcattcc tagaaattta 140 <212> Type: DNA <211> Length: 140       SequenceName: # 53       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccccagctg ttggctacat gagtatttag aggaagtaag gtagcaggca gtccagccct 60 gatgtggaga cacatgggat tttggaaatc agcttctgga ggaatgcatg tcacaggcgg 120 gactttcttc agagagtggt gcagcgccag acattttgca cataaggcac caaacagccc 180 aggactgccg agactctggc cgcccgaagg agcctgcttt ggtactatgg aacttttctt 240 aggggacacg tcctcctttc acagcttcta aggtgtccag tgcattggga tggttttcca 300 ggcaaggcac tcggccaatc cgcatctcag ccctctcagg agcagtcttc catcatgctg 360 aattttgtct tccaggagct gcccctatgg ggcgggccgc agggccagcc tgtttctcta 420 acaaacaaac aaacaaacag ccttgtttct ctagtcacat catgt 465 <212> Type: DNA <211> Length: 465       SequenceName: # 54       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaccacgtt ctttgtatgg gcccaatgag ctgtcaagct gccctgtgtt catttcattt 60 ggaattgccc cctctggttc ctctgtatac tactgcttca tctctaaaga cagctcatcc 120 tcctccttca cccctgaatt tccagagcac ttcatctgct ccttcatcac aagtccagtt 180 ttctgccact agtctgaatt tcatgagaag atgccgattt ggttcctgtg ggtcctcagc 240 actattcagt acagtgcttg atgcacagca ggcactca 278 <212> Type: DNA <211> Length: 278       SequenceName: # 55       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagcctgcaa actcactgct caagaagaca tggagactcc tgccctgttg tgtatagatg 60 caagatattt atatatattt ttggttgtca atattaaata cagacactaa gttatagtat 120 atctggacaa gccaacttgt aaatacacca cctcactcct gttacttacc taaacagata 180 taaatggctg gtttttagaa acatggtttt gaaatgcttg tggattgagg gtaggaggtt 240 tggatgggag tgagacagaa gtaagtgggg ttgcaaccac tgcaacggct tagacttcga 300 ctcaggatcc agtcccttac acgtacctct catcagtgtc ctcttgctca aaaatctgtt 360 tgatccctgt tacccagaga atatatacat tctttatctt gacattcaag gcatttctat 420 cacatatttg atagttggtg ttcaaaaaaa cactagtttt gtgccagccg tgatgc 476 <212> Type: DNA <211> Length: 476       SequenceName: # 56       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tagcagtgta gtctcaatta tatctgaaag taattgtgac taacaagtat gctttgcctt 60 atttccacat ttaaactacc tgttaatata agggatttgt agtatcagct tgttgagcaa 120 tgactttgaa tctagttttc agtgatcaga agcagcagtt atttgagtgt atgaatggaa 180 tgatgatcac tgtgctataa tgtactgaaa ccaccatatt acagaaatat ttactacata 240 ttttccatct gtagtttctc agaagggcta tggattagtt tgaactgtca aatccttgca 300 tacttctgtg acacccctgc ccattttctg tctttaatta accaaggtgt taggtgtgac 360 tgtcacaact gttatgtttt ccagtaaact agaagcacga tatttgataa ttatatttgt 420 atttcaccac ctaaatgtaa tgttgattcc tcaagaatga aatgaaggca ctacattgaa 480 atatgttttg tataaatttg tcatgttgaa cagcatttta gcat 524 <212> Type: DNA <211> Length: 524       SequenceName: # 57       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaagagcca gcgacgtggt ggccatcaga ataactacaa gccatactga ggcggccaag 60 ggagcgacca actgatcgca cacatgcttt gtttggatat ggagtgaaca caattatgta 120 ccaaatttaa cttggcaaac tttctattgc ctgtcccatg tgcatcttat ttaaaatttc 180 ccccatggaa atcactctcc tgttgactat ttccagagct ctaggtgttt aggcagcgtg 240 tggtgtctga gaggccatag cgccatcatg ggctgatttt tattaccagg tcccccagaa 300 gcaggtgaga ggctctgctt ctgctgccgc tctgcagcct ggacctgtgg accctggttg 360 taaagagtaa attgtatctt aggaaaccag tgtcaccttt ttttcacctt ttaattttat 420 attatttgcg tcatacattt cctgtaacgg aagtgttaat tttactgtac tttttggtac 480 cccttttggg aatctaatgt attgtaaggt attttacacg tgtcctgatt ttgccacaac 540 ctgga 545 <212> Type: DNA <211> Length: 545       SequenceName: # 58       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttaggtcaag ttcatagttt ctgtaattgg cttttgaatc aaagaatagg gagacaatct 60 aaaaaatatc ttaggttgga gatgacagaa atatgattga tttgaagtgg aaaaagaaat 120 tctgttaatg ttaattaaag taaaattatt ccctgaattg tttgatattg tcacctagca 180 gatatgtatt acttttctgc aatgttatta ttggcttgca ctttgtgagt atctatgtaa 240 aaatatatat gtatataaaa tatatattgc ataggacaga cttaggagtt ttgtttagag 300 cagttaacat ctgaagtgtc taatgcatta acttttgtaa ggtactgaat acttaatatg 360 tgggaaaccc ttttgcgtgg tccttaggct tacaatgtgc actgaatcgt ttcatgtaag 420 aatccaaagt ggacaccatt aacaggtctt tgaaatatgc atgtacttta tattttctat 480 atttgtaact ttgcatgttc ttgttttgtt a 511 <212> Type: DNA <211> Length: 511       SequenceName: # 59       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttaccaacc tgaatgacta ccgagangag tgtcttcaan gctcctgncc ccagncttac 60 ctacttggat nggctatgan ccgagangga ccaggnaagc acctgancnt cangnatgcc 120 gaggtggant nggtgntgga ntgnananga ggaggangga ncgaagaagg agaagatgag 180 gnaagancga nggacgnatn gaggatggtg aagaagagga gtttgatgaa ngaagantga 240 ntgaagatga ngaagatgta gaaggggatg aggacgacga tgaagtcagt gaggaggaag 300 aagaatttgg acttgatgaa gaagatgaag atgaggatga ggatgaagag gaggaagaag 360 gtgggaaagg tgaaaagagg aagagagaaa cagatgatga aggagaagat gattaagacc 420 ccagatgacc tgcagaaaca gaactgttca gtattggttg gactgctcat ggattttgta 480 gctgt 485 <212> Type: DNA <211> Length: 485       SequenceName: # 60       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaactagctc aacaatacta tcttgtgtac caagaaccca ttcctacagc tcagctggta 60 cagagagtag cttctgtgat gcaagaatat actcagtcag gtggtgttcg tccatttgga 120 gtttctttac ttatttgtgg ttggaatgag ggacgaccat atttatttca gtcagatcca 180 tctggagctt actttgcctg gaaagctaca gcaatgggaa agaactatgt gaatgggaag 240 actttccttg agaaaagata taatgaagat ctggaacttg aagatgccat tcatacagcc 300 atcttaaccc taaaggaaag ctttgaaggg caaatgacag aggataacat agaagttgga 360 atctgcaatg aagctggatt taggaggctt actccaactg aagttaagga ttacttggct 420 gccatagcat aacaatgaag tgactgaaaa atccagaatt tcagataatc tatctactta 480 aacatgttta aagtatgttt tgttttgcag actttttgca tacttatttc taca 534 <212> Type: DNA <211> Length: 534       SequenceName: # 61       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caccaaatta cctaggctga ggttagagag attggccagc aaaaactgtg ggaagatgaa 60 ctttgtcatt atgatttcat tatcacatga ttatagaagg ctgtcttagt gcaaaaaaca 120 tacttacatt tcagacatat ccaaagggaa tactcacatt ttgttaagaa gttgaactat 180 gactggagta aaccatgtat tcccttatct tttacttttt ttctgtgaca tttatgtctc 240 atgtaatttg cattactctg gtggattgtt ctagtactgt attgggcttc ttcgttaat 299 <212> Type: DNA <211> Length: 299       SequenceName: # 62       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaatgctgt gtgcattttc atgttctttt ttttagcatt actgtcactc tccctaatga 60 aatgtacttc agagaagcag tattttgtta aataaataca taacctcatt ctgaataatg 120 tccctcattt tgactataac tgtgcttggt ttcaaaagca aaattaaaca aaaatctcag 180 tcccctccga agtgaacttt gtgttaccct gcgtcagaaa tgccaagttg tgtttacttt 240 tcattcagat tttgtgaata tgaacatgct gttataggat ctacagatga atatttaact 300 caatagaaaa attattttag aacacattgt attggtatta caaccagatt atattcttga 360 cgttgacttc attaaa 376 <212> Type: DNA <211> Length: 376       SequenceName: # 63       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atctcttgaa acccatctct gtggaaggca gttcaaaaaa agtcaagact gatacagttc 60 ttatattgtg tagaaagaaa gtggaaaaca caaggtggga ttacctgacc caggttgaaa 120 aggagtgcaa agaaaaagag aagccctcct atgacactga aacagatcct agtgagggat 180 tgatgaatgt tctaaagaaa atttatgaag atggagacga tgatatgaag cgaaccatta 240 ataaagcctg ggtggaatca agagagaagc aagccaaagg agacacggaa ttttgagact 300 ttaaagtcgt tttgggaact gtgatgtgat gtggaaatac tgatgtttcc agtaagggaa 360 tattggtgag ctgcatatat aaatttgaca gatagctatt tacatagcct tctaagtaaa 420 ggcaatgaat tctccatttc ctactggagg atttatttaa ataaaatatg cttattaaac 480 actcctgcaa agatggtttt attagtaccc tggtcatttt gttcaaggaa gggttatatt 540 gcattctcac gtgaa 555 <212> Type: DNA <211> Length: 555       SequenceName: # 64       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttggggtata ggtctcatct cttcaggttc tcatgatacc acctttactg tgcttatttt 60 tttaagaaaa aagtgttgat caaccattcg acctataaga agccttaatt tgcacagtgt 120 gtgacttaca gaaactgcat gaaaaatcat gggccagagc ctcggcccta gcattgcact 180 tggcctcatg ctggagggag gctgggcggg tacagcgcgg aggaggaggg aggccaggcg 240 ggcatggcgt ggaggaggag ggaggccggg cggtcacagc atggaggagg agggaggcgc 300 tgctggtgtt cttattctgg cggcagcgcc tttcctgcca tgtttagtga atgacttttc 360 tcgcattgta gaattgtata tagactctgg tgttctattg ctgagaagca aaccgccctg 420 cagcatccct cagcctgtac cggtttggct ggc 453 <212> Type: DNA <211> Length: 453       SequenceName: # 65       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttgtgcttc taactggtgc tgccagcttt ataatggtgg cccacctagc catcaatgtt 60 tccaaggccc gcaagaagta caaagtggag tatcctatca tgtacagcac ggaccctgaa 120 aatgggcaca tcttcaactg cattcagcga gcccaccaga acacgttgga agtgtatcct 180 cccttcttat tttttctagc tgttggaggt gtttaccacc cgcgtatagc ttctggcctg 240 ggcttggcct ggattgttgg acgagttctt tatgcttatg gctattacac gggagaaccc 300 agcaagcgta gtcgaggagc cctggggtcc atcgccctcc tgggcttggt gggcacaact 360 gtgtgctctg ctttccagca tcttggttgg gttaaaagtg gcttgggcag tggacccaaa 420 tgctgccatt aaagaattat aggggtttaa aaactctcat tcattttaaa tgacttacct 480 ttatttccat ttacattttt tttctaaata taataaaaac ttacctggca tcagcctcat 540 a 541 <212> Type: DNA <211> Length: 541       SequenceName: # 66       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcgacatgg ccaaacgtac caagaaagtc gggatcgtcg gtaaatacgg gacccgctat 60 ggggcctccc tccggaaaat ggtgaagaaa attgaaatca gccagcacgc caagtacact 120 tgctctttct gtggcaaaac caagatgaag agacgagctg tggggatctg gcactgtggt 180 tcctgcatga agacagtggc tggcggtgcc tggacgtaca ataccacttc cgctgtcacg 240 gtaaagtccg ccatcagaag actg 264 <212> Type: DNA <211> Length: 264       SequenceName: # 67       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcatggcgag taccaggatg actaccccag agattaccaa tatagcgacc aaggcattga 60 ttattagatc cacacagaag gagctcagta tttagtcctt tgtttttatt cagtgagaac 120 caagctagcc ttgagtaatt tttatcttgt cttcctaaaa cactattaag cttattgtac 180 ttttaagaaa aattgcctta cgtacattcc tttttccttt ttctgcctct tccctcaata 240 gttgcctttt agtgctgtaa taggttaaat cctacagcat aatcaataac tcgcatatga 300 agtaaaaagg aatactgtga aaggggagta ctcttgtaca gccagttctt ttatgcaaaa 360 atctatgcat ttttacaatc tta 383 <212> Type: DNA <211> Length: 383       SequenceName: # 68       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatcttcagc caggcctttc tgaaggagtt attctgctaa aaatggtctt agttgtctga 60 aaagccagct cttgaacctc ttcacaacag tatcaacact ggcttctccc ggttcatttt 120 atgcgtgcga gaagtcagtg gtaactgctg cagggcttaa tacattagtg gtaactggtt 180 taaaaaacaa agactgtaag cctgtgtgtg ccactgtttg cttcaacagt atatcnnnct 240 aataagcctc acctatttaa tccaat 266 <212> Type: DNA <211> Length: 266       SequenceName: # 69       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctctgttgct attgtcttct ataagtggag tttcatgact tactgcttaa cgaataacta 60 actactatga tattctggac attttaggaa atggtaattt gccttgctac acattaagag 120 ggctattaag actacatttt ttctaacctc agataagtgc agtgtctttg caatgccaac 180 ataagggaga tcttggccaa cgtgaaataa aattactcat tcaaaactct gcctaaggtg 240 attttgtagt tcttaacagt tctccagagc atcttgaaca ggaatattaa gataaatgtg 300 aatctgcaat ggctgaaaag agttgtgagc ttttttattc atgataaaac cttataggaa 360 tagtataaaa aatccctgtg gaaagctact agtacattga ccagcgctgg gtgatacaga 420 ttctgataaa aacataaatg tattagttca tctccatgta gt 462 <212> Type: DNA <211> Length: 462       SequenceName: # 70       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtatatgact gcactagctc ttcctttgat ggaatcattg cgatgatgag tccagaggac 60 agctgggtct ccaagtggca gcgagtcagt aactttaagc caggtgtata tgcggtgtca 120 gtcactggtc gcctgcccca aggaatcgtg cgggagctga aaagtcgagg agtggcctac 180 aaatccagag acacagctat aaagacctag caagatgcaa ggctgccagc atctttgctc 240 tccacctcct gcctctgctt atttcttgtt ctggaactaa atgaacagaa cttcaaatac 300 ttcctaccct ccaattcaga ctcagctgac tgttgagaga gcagcacatc attttatcat 360 tttatcttct ttggactaca ggtggggtgg gagggatttg ggttggtgga ttaacagatg 420 gaattgagga gagagtagga tgctgatttt cctacccgtg 460 <212> Type: DNA <211> Length: 460       SequenceName: # 71       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttggttcagt tttccggagg gcgagctgag ccctggccgc cgccacaatg ggccgcgagt 60 ttgggaatct gacgcggatg cggcatgtga tcagctacag cttgtcaccg ttcgagcagc 120 gcgcctatcc gcacgtcttc actaaaggaa tccccaatgt tctgcgccgc attcgggagt 180 ctttctttcg cgtggtgccg cagtttgtag tgttttatct tatctacaca tgggggactg 240 aagagttcga gagatccaag aggaggatcc agctgcctat gaaaatgaca aatgagcaac 300 gcatccggat gacggttccc tgtctctgaa agacctttct ctgga 345 <212> Type: DNA <211> Length: 345       SequenceName: # 72       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagctgctta ttactgtggc attcaatcaa cctgttaagc tttattccat gaaatttcaa 60 gggccagata atggtcaggg ccctaaatat gtaaaaattt ttatcaacct accccgatct 120 atggattttg aagaggcaga aagaagtgaa ccaactcaag ctctggaact gacagaggat 180 gatattaaag aagatggcat tgttccactt cgttatgtta agtttcagaa tgttaacagt 240 gtaactatat ttgttcagtc gaatcaaggt gaagaggaaa caacaagaat ttcatatttt 300 acttttattg gtactccagt ccaggcaaca aatatgaatg acttcaaacg agtagttggc 360 aaaaaaggag aaagccacta aggtacaaaa gacactggac aaccatattg caatcagatc 420 tacagctcct ggataattgc ttgattctcg ccagagactg tcaatgtttc attcattgcc 480 attaccaata aatcattgct tttgttcaga tggtatcact agtgtttcca ttgtaatctt 540 gacacatg 548 <212> Type: DNA <211> Length: 548       SequenceName: # 73       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagccaagat gctgcggaat ctgctggctc ttcgtcagat tgggcagagg acgataagca 60 ctgcttcccg caggcatttt aaaaataaag ttccggagaa gcaaaaactg ttccaggagg 120 atgatgaaat tccactgtat ctaaagggtg gggtagctga tgccctcctg tatagagcca 180 ccatgattct tacagttggt ggaacagcat atgccatata tgagctggct gtggcttcat 240 ttcccaagaa gcaggagtga cttcagtcat cccagcaatc gcttggttca gtttcattca 300 gctctctatg gaccagtaat ctgataaata accgagctct tctttgggga tcaatattta 360 <212> Type: DNA <211> Length: 360       SequenceName: # 74       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaaagggatc cagtttccag ctgcaggttt gttagagtct gttctacatg ggcctgccct 60 cctgtgatgg gcagaggctc ctggtacatc gagaagattc ctgtggatcc cgtcaggagg 120 gacttagtgg ctctgccgcc agtgagactt cccgccggca gctgtgcgca ccaaagactc 180 gggagaactg gaaaggctgt ctggggtctt ctgactgcag gggaaggatg tactttccaa 240 acaaatgata caaccctgac caagctaaaa gacgcttgtt aaaggctatt ttctatattt 300 attgttggga aaagtcactt taaagacttg tgctatttgg aagcaaagct attttttttg 360 tcagtggaat gcagtttttt tactattcca tcatgaggaa caacatagat tccatgatct 420 ttttaatgac agtacagact gagatttgaa ggaaacatgc acaaatctgt aaaacataga 480 ccttcgcttt atttttgtaa gtatcacctg ccacca 516 <212> Type: DNA <211> Length: 516       SequenceName: # 75       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctcctctccc tgttagaaat gttagtgccc cgcactgtgc cccaagttct aggcccccca 60 gaaagctgtc agagccggcc gccttctccc ctctcccagg gatgctcttt gtaaatatcg 120 gatgggtgtg ggagtgaggg gttacctccc tcgccccaag gttccagagg ccctaggcgg 180 gatgggctcg ctgaacctcg aggaactcca ggacgaggag gacatgggac ttgcgtggac 240 agtcagggtt cacttgggct ctctctagct ccccaattct gcctgcctcc tccctcccag 300 ctgcacttta accctagaag gtggggacct ggggggaggg acagggcagg cgggcccatg 360 aagaaagccc ctcgttgccc agcactgtct gcgtctgctc ttctgtgccc agggtggctg 420 ccagcccact gcctcctgcc tggggtggcc tggccctcct ggctgttgcg acgcgggctt 480 ctggagcttg tcaccattgg acagtctccc tgatgga 517 <212> Type: DNA <211> Length: 517       SequenceName: # 76       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgttcatgaa gactccctta cagttgtttt tgaaaataat tggcaaccag aacgccaggt 60 tccatttaat gaagttagat taccaccacc acctgatata aaaaaagaaa ttagtgaagg 120 agatgaagta gaggtatatt caagagcaaa tgaccaagag ccatgtgggt ggtggttggc 180 taaagttcgg atgatgaaag gagaatttta tgtcattgaa tatgctgctt gtgacgctac 240 ttacaatgaa atagtcacat ttgaacgact tcggcctgtc aatcaaaat 289 <212> Type: DNA <211> Length: 289       SequenceName: # 77       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgcgttcgca ccaaaaccgt gaagaaggcg gcccgggtca tcatagaaaa gtactacacg 60 cgcctgggca acgacttcca cacgaacaag cgcgtgtgcg aggagatcgc cattatcccc 120 agcaaaaagc tccgcaacaa gatagcaggt tacgtcacgc atctgatgaa gcgaattcag 180 agaggcccag taagaggtat ctccatcaag ctgcaggagg aggagagaga aaggagagac 240 aattatgttc ctgaggtctc agccttggat caggagatta ttgaagtaga tcctgacact 300 aaggaaatgc tgaagctttt ggacttcggc agtctgtcca accttcaggt cactcagcct 360 acagttggga tgaatttcaa aacgcctcgg ggacctgttt gattttttct g 411 <212> Type: DNA <211> Length: 411       SequenceName: # 78       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagggatgta tgttgcttgc ttgagagggt ttcttttact tcaaaatctt tcttcaggga 60 gcaagacatg aactgactaa ttggtatcca ctacttgtac agcttacata aatgagttga 120 tgatatttaa ccagttttta taaacttcat ttaggtctct aaacacagac tttttaaatt 180 gcaactgtaa atatgaaatg gtcatcacat ctgaccttgg tcagtgggga ggggaactgg 240 tatcctgcca agcctggttg taatttgtaa ccattttcta tttgtgcaaa ctctgtaaat 300 atgtgtttaa acaaatgtaa tattttgtac aagatacact ggagaacaaa gggaactcaa 360 gattcttcca gccacatgtc acctgtaggt agaagtaaac tctgcagtgc agcttctgct 420 cttggcccct ctgccagggc ccctgtggct tcctgcacac tggacaggtg actgtatggt 480 agagactgtg atctgggaac tttttgctgt ac 512 <212> Type: DNA <211> Length: 512       SequenceName: # 79       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggtcccatt acaaagcatg gtgaaataga ttatgaagca attgtgaagc tttcggatgg 60 ctttaatgga gcagatctga gaaatgtttg tactgaagca ggtatgttcg caattcgtgc 120 tgatcatgat tttgtagtac aggaagactt catgaaagca gtcagaaaag tggctgattc 180 taagaagctg gagtctaaat tggactacaa acctgtgtaa tttactgtaa gatttttgat 240 ggctgcatga cagatgttgg cttattgtaa aaataaagtt aaagaaaata atgtatgtat 300 tggcaatgat gtcattaaaa gtatatgaat aaaaatatga gtaacatcat aaaaattagt 360 aattcaactt ttaagataca gaagaaattt gtatgtttgt taaagttgca tttattgcag 420 caagttacaa agggaaagtg ttgaagcttt tcatatttgc tgcgtgagca ttttgtaaaa 480 tattgaaagt ggtttgagat agtggtata 509 <212> Type: DNA <211> Length: 509       SequenceName: # 80       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcgccgctag ctgggaaaac actagagctg caggtaccag ccactcggcc ccagggggtt 60 atggccacag agggataggc acagtctcca ccaccctgga gccaagggtc tttcacatca 120 cctatcccta catacatacc aaatggaaaa gtggccatcc ttttcccccc aaacacaccc 180 ccttaaccta tctcttggga cttagcccga ccctccctct catttcccat taagtctgag 240 aggcaagagc taggttaggc aaggaggtgg ttggccagag atggggaaca gccaggtgcc 300 ccagtcctct gatttttcct ccatcctgct taccacctcc ctgggtactt acagccttct 360 cttgggaaca gccggggcca ggactgggtc acctatgagc tgaatcagca tctcctcctg 420 agtcccaggg cccctgcagt tcccagtctc ttctgtcctg cagcccttgc ctctttccca 480 caggttccac tttatat 497 <212> Type: DNA <211> Length: 497       SequenceName: # 81       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggccatctc ctaatggacc aaggacccca gagcccacct gtgtgacgct gcctttttat 60 acactgtcct cctccacctt gatggacccc tagtgatgca tcctgcctag gct 113 <212> Type: DNA <211> Length: 113       SequenceName: # 82       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttctcttgg aggttggcat tgtaaaggag gaacagctta aggttcatgg attctaaaat 60 gaacctaaat acgtggagaa tttcttgaat agttttgttc tctaaacccg gtttggctgc 120 cttgtgaaat gattccctgc agtaaacgga cttttcattt atttaatcat tcaaacttcc 180 attcacatct gcatgattac agaaaacatg gggtatgtag actagtaaca cataagaaaa 240 ttgcagtaag atggtaacaa aacctcatat tgtctttaca tgtttccaat ggaaaatgtt 300 ttgagtgttt attgttcagt ttattacgtt tcacttgatt aaattttttt tgttgttgta 360 ttaaaccatg tacgttgcag cttaaca 387 <212> Type: DNA <211> Length: 387       SequenceName: # 83       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaggacgtt ggtgttgagg ttagcatacg tatcaaggac agtaactacc atggctcccg 60 aagttttgcc aaaacctcgg atgcgtggcc ttctggccag gcgtctgcga aatcatatgg 120 ctgtagcatt cgtgctatcc ctgggggttg cagctttgta taagtttcgt gtggctgatc 180 aaagaaagaa ggcatacgca gatttctaca gaaactacga tgtcatgaaa gattttgagg 240 agatgaggaa ggctggtatc tttcagagtg taaagtaatc ttggaatata aagaatttct 300 tcaggttgaa ttacctagaa gtttgtcact gacttgtgtt cctgaactat gccacatgaa 360 <212> Type: DNA <211> Length: 360       SequenceName: # 84       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgaagcgca gaaagctcgg ccggtacaac gaggaggagc gggctcagca ggaggccgag 60 gccgcccagc gcctggccga ggagaaggcc caggccagct ccatccccgt gggcagccgc 120 tgtgaggtgc gggcggcggg acaatcccct cgccggggca ccgtcatgta tgtaggtctc 180 acagatttca agcctggcta ctggattggt gtccgctatg atgagccact ggggaaaaat 240 gatggcagtg tgaatgggaa acgctacttc gaatgccagg ccaagtatgg cgcctttgtc 300 aagccagcag tcgtgacggt gggggacttc ccggaggagg actacgggtt ggacgagata 360 tgacacctaa ggaattcccc tgcttcagct cctagctcag ccactgactg cccctcctgt 420 gtgtgcccat ggcccttttc tcctgacccc attttaattt tattcatttt ttcctttgcc 480 att 483 <212> Type: DNA <211> Length: 483       SequenceName: # 85       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatcactgtc tgacatcctg caggccctgg tgctcacagg tggagagaag aagccctgag 60 ctgggggaag gggtcatgca gcaccagggg atatgcccaa ctcactgcct gctggaagct 120 ctgtgggaat cagatgaaac ttgagggaat tgtgactctg ttccctgttc agggtcccct 180 gcccttctat ctgggagcta gggaaggtat gggggaggaa agagaatgga tttatagcta 240 cccttaccct cacacataca cttgaaaaaa ctttcagcct agccagttct agcccctgtc 300 ctcttagata tatccccctt tctgggtgaa ctataggctc tgtgcctctc agacaaattc 360 tgatctctaa gagatcccca gacctcactt gcctctgcct ccatcttggc cctgattcaa 420 ccctaagata atagcacaac aaaattcttc ataaagatat ttttattcac ctgttccgtg 480 ctatat 486 <212> Type: DNA <211> Length: 486       SequenceName: # 86       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgtcgccat ggtgaagctg agcaaagagg ccaagcagag actacagcag ctcttcaagg 60 ggagccagtt tgccattcgc tggggcttta tccctcttgt gatttacctg ggatttaaga 120 ggggtgcaga tcccggaatg cctgaaccaa ctgttttgag cctactttgg ggataaagga 180 ttatttggtc ttctggattt ggaggcaatc agcggacagc atggaagatg tgtgctctgg 240 ctcggataag agatgggaca tcattcagtc actagttgga tggcacaagg ctcttcacag 300 acgcatctgt 310 <212> Type: DNA <211> Length: 310       SequenceName: # 87       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatttcaggg ctcttggcgt gttggacaca gaagaaatcc tagtgcagcc tttggtagct 60 aacagtcact gattttataa ttggagaatg cgtaaagatt catttttcaa ggagaagagc 120 ctgcaaatgg ccaatgaagg aggtaaataa actaagatat tccgagggaa gggacccagg 180 ccacctccct tccgcaggtc tgcagatgaa gggttttttg aatgaaatgc cactgcgcat 240 tttcagaaaa aaaaatctct gataaacaga ctttgaatgg atgtttgttc ctcctgattc 300 tcttttctct tcgtggcgac ttagagttgg cggatattcg gaactgtgaa tgtacatagc 360 gttgagttaa accccttgtg tgtgagacag gacgcagcgg gcccctggtg gcctgggggc 420 cagacccgtg ggcaggtggg gcatg 445 <212> Type: DNA <211> Length: 445       SequenceName: # 88       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctactttga attaatctgc ctttatgttt gggagaagaa agctgagaca ttgcatgaaa 60 gatgatgaga gataaatgtt gatcttttgg ccccatttgt taattgtatt cagtatttga 120 acgtcgtcct gtttattgtt agttttcttc atcatttatt gtatagacaa tttttaaatc 180 tctgtaatat gatacatttt cctatctttt aagttattgt tacctaaagt taatccagat 240 tatatggtcc ttatatgtgt acaacattaa aatgaaaggc tttgtcttgc attgtgaggt 300 acaggcggaa gttggaatca ggttttagga ttctgtctct cattagctga ataatgtgag 360 gattaacttc tgccagct 378 <212> Type: DNA <211> Length: 378       SequenceName: # 89       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaactgcgc attctctagt agtatatatc gtgcctgtct tcaaaaacat ttcccttttt 60 atactcattc cccccaggca tggggtagtg tcagtcggac tgcacaggga acacggntnc 120 cagtggcttt ggcccctact cgggaaacgt ctgcctgttc tcgatggtga tggggtggct 180 gccattccct tggttttcct aagccctttc taacgagagt ctcaaacaag cggaggcgag 240 ggccaattca accccattct ttccagcgcc ccgcaccata gcacctgccc acctgagaac 300 caggaacgca ccctctctgt ggagctctga ctggtgtanc tggaaacaaa cagcaacttg 360 caaacggacg aagagcctgc cgtgtgttaa tcatttgcct tac 403 <212> Type: DNA <211> Length: 403       SequenceName: # 90       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttgtctgga aacctgctga ggaaattcaa aaacagcaac gggtggcaga agctgtgggt 60 ggtgttcaca aacttctgcc tgttcttcta caaatcacac caggacaatc atccccttgc 120 cagcctgcct ctgctcggct actcgctcac catcccctct gagtccgaga acatccagaa 180 agactacgtg ttcaagctgc acttcaagtc ccacgtctac tacttcaggg cggaaagcga 240 gtacacgttc gaaaggtgga tggaagtgat ccgcagtgcc accagctctg cctcgcgacc 300 ccacgtgttg agccacaaag agtctcttgt gtattgatgg ccggacacac tcgtttccgc 360 agtggctgct ttcctggaag acgtttcctt tcttctgtat taatgaagcc tggtaaaatt 420 aacacctgtc tgaaaatcaa a 441 <212> Type: DNA <211> Length: 441       SequenceName: # 91       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatacttat aaactgttgt tcctggaagt tatttattcc ataaaaaatt tgttcttttc 60 tcatgaattt ataattccta aatgaagacc agaaagtaca aattgctggg aggaagaata 120 ggctttatta atcaactgat gtcttgattt ttctaaatgg gaagattgct ttatttttaa 180 cactaattat gggagcagat tcttaccaaa cttctttgga aaagttaatg ttatgatgtg 240 cattaggctg ccccatcgtg tatataaatg aaggcagatt tgatttttgt attcttacgt 300 ttactctgct ttgtagttgt ggctgtactt aaagcaatac agaatttcat atatttaaaa 360 atgtttaaaa tgtgacccac agaacattgt aaatgattaa aaactaacat gaaaatatta 420 caacctaaaa gaattcttaa cttcacaagt gttttacttc gacgatgtgc ctttgattta 480 atttgggaca cttttttaga aggatacatt attcgtgttt gcaacggtct ttga 534 <212> Type: DNA <211> Length: 534       SequenceName: # 92       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctgcacaga cgtgctcagc agggctacag gtgctcaagc cctattgggg atgggtgggg 60 agtggggcag cggcgtttgc caccttaaga attggggcca aagccactga tgtttatttg 120 acagtgacac tgcactgggt acttaaagaa attatttccc gttgtaatta taattactgc 180 ttattaagga aaatatggga attttagaaa gaatcaagtt tgccacccaa atgctaccac 240 tgttaatctt ttggtgttaa atgttccccc tagacatttc tgtgcataga tttttggtgt 300 gtttacatag tcgttattct gtatatacaa ttttatgtcc cttttgtact taacgtat 358 <212> Type: DNA <211> Length: 358       SequenceName: # 93       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaactgtagt ttgcctccaa gacaccattg tctcccttta atcttctctt ttgtatacat 60 ttgttaccca tggtgttctt tgttcctttt cataagctaa taccactgta gggattttgt 120 tttgaacgca tattgacagc acgctttact tagtagccgg ttcccatttg ccatacaatg 180 taggttctgc ttaatgtaac ttcttttttg cttaagcatt tgcatgacta ttagtgcttc 240 aaagtcaatt tttaaaaatg cacaagttat aaatacagaa gaaagagcaa cccaccaaac 300 ctaacaagga cccccgaaca ctttcatact aagactgtaa gtagatctca gttctgcgtt 360 tattgtaagt tgataaaaac atctggaaga aaatgactaa aactgtttgc atctttgtat 420 gta 423 <212> Type: DNA <211> Length: 423       SequenceName: # 94       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcccacccct ccagaaataa gctggaaatc ttaacntttt ggggggtcnt ttttggtgtt 60 ttaatgggcc cagaactgtg gtttaaattt ttatgtatgt attttctttt ttgtggagta 120 taaatttaaa aactggattt gggacctaaa atactcctca ggttgatgta ttcatgaagt 180 tttaaaacat ctttagtttt caaagtaaac tggatatgtg gaccttaaag ttattgagtt 240 taagctacaa attgtaacgt cattactgga catgtcagca tcaaccctct caaaatagct 300 tggtcacttt atgaaggggc gttttaaagt tgttgtttag cagtgacatt taatatggtc 360 caattgcttt tctttttaac gtgacaaaaa gagaataagg aacaaacact attgctgccg 420 aatgccataa cactgagt 438 <212> Type: DNA <211> Length: 438       SequenceName: # 95       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagcccattt tcagtcggga catgaacgag gccaagcgga gggtgcgcga gctctaccgc 60 gcctggtatc gggaggtgcc gaacactgtg caccaattcc agctggacat cactgtgaaa 120 atgggacggg ataaagtccg agaaatgttt atgaagaatg cccatgtcac agaccccagg 180 gtggttgatc ttctggtcat taagggaaag atcgaactgg aagaaacaat taaagtatgg 240 aagcagcgga cacatgttat gcggttcttc catgaaacag aagcgccaag gccaaaggat 300 ttcctatcca agttctatgt tggccacgat ccatgaagtc attcagtgga aagatgcacg 360 ttgatactat ttt 373 <212> Type: DNA <211> Length: 373       SequenceName: # 96       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtgtgatag gtgtgagtgt ctctagggtg atacgtgggt gagaaaggtc ctggtccgcg 60 ccagagccca gcgcgcctcg tcgccatgcc tcggaaaatt gaggaaatca aggacttcct 120 gctcacagcc cgacgaaagg atgccaaatc tgtcaagatc aagaaaaata aggacaacgt 180 gaagtttaaa gttcgatgca gcagatacct ttacaccctg gtcatcactg acaaagagaa 240 ggcagagaaa ctgaagcagt ccctgccccc cggtttggca gtgaagga 288 <212> Type: DNA <211> Length: 288       SequenceName: # 97       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agacgaggct cgggactttg cagccggcct tagtgctcgc gcaggttcct ggtagagtta 60 cacagttgtg ccgccagtat agcgacatgc ctcctttgac gttagagggc atccaggacc 120 gtgttcttta cgtattgaaa ctctatgaca agattgaccc agagaagctt tcagtaaatt 180 ctcattttat gaaagacctg ggcttagaca gtttggacca agtggagatt atcatggcca 240 tggaagacga atttgggttt gaaattcctg atatagatgc tgaaaagtta atgtgtccac 300 aagaaattgt agattacatt gcagataaga aagatgtata tgaataaagt atcagaccct 360 ttggctttgc tgagagagga ctcagatgat agtgacgaat gtctggcagt gaggacacat 420 tttggcattc ttgctgactc tgacagag 448 <212> Type: DNA <211> Length: 448       SequenceName: # 98       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaccttttta actctatcat tacaagatat ggcaagtcgt gtgcagttgt ctggacctca 60 ggaggcagag aaatacgttc tgcacatgat agaagatggt gagatttttg caagtattaa 120 ccagaaggac ggtatggtca gtttccatga taaccctgaa aaatataata acccagccat 180 gcttcataac attgatcagg agatgctgaa gtgcattgag ctggatgagc ggctgaaagc 240 catggaccag gagatcacag tgaaccctca gtttgtacaa aagagtatgg gctcacaaga 300 agatgattca ggaaacaaac catccagtta ttcttgaaac taacatccat cctgagctaa 360 acaagagaaa ctaccatctt ggccagtgac aagtgttcgg agggcagcag agaggaccaa 420 gcctgtgtca cctggagact aaaaaattaa gttttgtttt gacatcttca gtcctgtgtg 480 ctt 483 <212> Type: DNA <211> Length: 483       SequenceName: # 99       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggtcaagaa ctgggtcccg acggcctaca catggggcgc tgtgggcgcc gtggggctgg 60 tgtgggccac cgattggcgg ctgatcctgg actgggtacc ttacatcaat ggcaagttta 120 agaaggataa ttaattacac aaacccttca cagactgctc tggtgcctgg tggtgctagc 180 tcctcccacc tcagcacctg ctgcatctgg agcagcccaa gctctcagga tggacaagag 240 gaaacccaca gctcagcttc aggcttctta tgtttctgaa aac 283 <212> Type: DNA <211> Length: 283       SequenceName: # 100       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcagctcact tcaagggtac ctgaagcgaa ttggcaccaa agcagcagct gtattgccgc 60 agttctagct tcaccttcac gatgtttccc ttggtcaaaa gcgcactaaa tcgtctccaa 120 gttcgaagca ttcagcaaac aatggcaagg cagagccacc agaaacgtac acctgatttt 180 catgacaaat acggtaatgc tgtattagct agtggagcca ctttctgtat tgttacatgg 240 acatatgtag caacacaagt cggaatagaa tggaacctgt cccctgttgg cagagttacc 300 ccaaaggaat ggaggaatca gtaatcatcc cagctggtgt aataatgaat tgtttaaaaa 360 acagctcata attgatgcca aattaaagca ctgtgtaccc attaagata 409 <212> Type: DNA <211> Length: 409       SequenceName: # 101       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gattgttgac cgttaagaag accttggatg ttgttccagt tatgctggat tccacagtga 60 aatcatttaa aaccatctaa ataaaccact atatatttta tgaattacat gtggttttat 120 atacacacac acacacacac acacacacac acacactctg acattttatt acaagctgca 180 tgtcctgacc ctctttgaat taagtggact gtggcatgac attctgcaat actttgctga 240 attgaacact attgtgtctt aaatacttgc actaaatagt gcactgcaag accagaaaat 300 tttacaatat ttttctttac aatatgttct gtagtatgtt taccctcttt atgaagtgaa 360 ttaccatgct ttgaataatg ttcacttata cttcctgttc gaaattacga 410 <212> Type: DNA <211> Length: 410       SequenceName: # 102       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttgaagaaag attgtcccca ggcacagtat ctgaatcact ggggattatg attcaccctc 60 tttggagaac atgctctctt ttcacccccc acctcctgag agccactaat gtaagataca 120 gaaacatagc tgaggaacaa atagaccatt tccatactaa accagtttgt taactttaga 180 ttttttccaa tagtgtgagt atatccattg ctggcagtgg agggcttgcc atgaaaatgc 240 aacttattta agacatttat gagacatatt aacttgtgct gtcgcctttt agaaggagaa 300 acttaagtgt ggaatgcatt atatgggcaa agaagctatg aagatacatg atacactttg 360 tacaactatc ctgcagccca ttggttgctt atatttatcg cttggctcaa gttctgccct 420 ttggagaaat actgagcaag tctttcattc tctgtgtgac agccctctga atatttgaag 480 ttgtttgttg taacttaagg ttataacagc ccttagttca tttactctgc atttgttcaa 540 <212> Type: DNA <211> Length: 540       SequenceName: # 103       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acagcacggc catccaggag ctgttcaagc gcatctccga gcagttcacg gccatgttcc 60 ggcgcaaggc cttcctgcac tggtacacgg gcgagggcat ggacgagatg gagttcaccg 120 aggccgagag caacatgaac gacctggtgt ccgagtacca gcagtaccag gacgccacgg 180 ccgaggaaga gggcgagatg tacgaagacg acgaggagga gtcggaggcc cagggcccca 240 agtgaaactg ctcgcagctg gagtgagagg caggtggcgg ccggggccga agccagcagt 300 gtctaaaccc ccggagccat cttgctgccg acaccctgct ttccccatcg ccctagggct 360 cccttgccgc cctcctgcag tatttatggc ctc 393 <212> Type: DNA <211> Length: 393       SequenceName: # 104       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagatggtca tctggattct cccacttctc tactccatta tttctctact tttccttcca 60 gcaaaccttg aaacgtgagg gagatggatt aatgtgagta acaggaatgt gtctttaaaa 120 agctagagtg gttacattta atcaggcagt aagataattt gggttcttga gttgttttgg 180 agtaatatcc cacaactggg gtaggaagct caggactttt ttctttaaag ctagtcattt 240 caaaagcata ttgtattttt ttgaatgact acagtatgga caatttcaaa aaccaaaacc 300 cactttggat tggtggaagt aaaaactggt aactcactca agtgaatgaa tggtcttgca 360 ttttaaaagc ttatgggaaa ctcaatttga 390 <212> Type: DNA <211> Length: 390       SequenceName: # 105       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggcaaaacc ttaaatctcc aggcttttta aagcacaaaa tataaataaa agctgggaaa 60 gtaaaccaaa attcttcaga ttgttcctca tgaatatccc ccttcctctg caattctcca 120 gagtggtaac agatgggtag aggcagctca ggtgaattac ccagcttgcc tctcaattca 180 ttcctcctct tcctctcaaa ggctgaaggc agggcctttc cagtcctcac aacctgtcct 240 tcacctagtc cctcctgacc cagggatgga ggctttgagt cccacagtgt ggtgatacag 300 agcactagtt gtcactgcct ggctttattt aaaggaactg cagtaggctt cctctgtaga 360 gctctgaaaa ggttgactat atagaggtct tgtatgtttt tacttggtca agtatttctc 420 acatcttttg ttatcagagt accattccaa tctcttaact tgc 463 <212> Type: DNA <211> Length: 463       SequenceName: # 106       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtagcagttc cctgaccaag ggcaaggtgt gtctcaggaa ggtggttctg tgcatgcctg 60 ggtgtggtta aggcgtggcc cagaaggctt ccctggtgct ctcagtccag gcaaagccca 120 gagcatctga gcacgtctct gacttccagt ggcaacacag tttgaacgtg gtgaaacagg 180 gtgtagttct tttccacatt ctgtgtcatc tagtcgtgca ggtagggaaa aagttggtct 240 aattgaagat tgtgcatttc ctagtgacag gtgccaagag gttatgatac gggtttcttg 300 ggtctgatgt acagtgtgaa taaatgcttg cagctcttag ctcttttttg atcgatgaag 360 cactttttta ttaatatttt cctttgttaa aggaggaacc gtaactctcc atagctgtac 420 atataaccct tttctcc 437 <212> Type: DNA <211> Length: 437       SequenceName: # 107       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagcttcgag ctgttgcgtg tgtgagtctg ttgtgtggat gtgcgtgtgt ggtccccagc 60 cccagactgg attggaaaag tgcatggtgg gggcctcggg gctgtcccca cgctgtccct 120 ttgccacaag tctgtggggc aagaggctgc aatattccgt cctgggtgtc tgggctgcta 180 acctggcctg ctcaggcttc ccaccctgtg cggggcacac ccccaggaag ggaccctgga 240 cacggctccc acgtccaggc ttaaggtgga tgcacttccc gcacctccag tcttctgtgt 300 agcagcttta acccacgttt gtctgtcacg tccagtcccg agacggctga gtgaccccaa 360 gaaaggcttc cccgacaccc agacagaggc tgcagggctg gggctgggtg agggtggcgg 420 gcctgcgggg acattctact gtgctaaa 448 <212> Type: DNA <211> Length: 448       SequenceName: # 108       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatgcccaca ggtgtattgt cgaaccattg aaagatccaa atgcatttct ttttgaccac 60 cttcttactt taaaaccagt caagtttttg gaaggcgagc ttattcatga tcttttaacc 120 atttttgtga gtgctaaatt ggcatcatat gtcaagtttt atcagaataa taaagacttc 180 attgattcac ttggcctgtt acatgaacag aatatggcaa aaatgagact acttactttt 240 atgggaatgg caatagaaaa taaggaaatt tcttttgaca caatgcagca agaacttcag 300 attggagctg atgatgttga agcatttgtt attgacgccg taagaactaa aatggtctac 360 tgcaaaattg atcagaccca gagaaaagta gttgtcagtc atagcacaca tcggacattt 420 ggaaaacagc ggtggcaaca actgtatgac acacttaatg cctggaaaca aaatctgaac 480 aaagtgaaaa acagcctttt gagtctttcc gatacctgag tttttatgct tataa 535 <212> Type: DNA <211> Length: 535       SequenceName: # 109       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctcgtgttg aatctagaac cgtagccaga catgggactg gaggacgagc aaaagatgct 60 taccgaatcc ggagatcctg aggaggagga agaggaagag gaggaattag tggatcccct 120 aacaacagtg agagagcaat gcgagcagtt ggagaaatgt gtaaaggccc gggagcggct 180 agagctctgt gatgagcgtg attcctctcg atcacataca gaagaggatt gcacggagga 240 gctctttgac ttcttgcatg cgagggacca ttgcgtggcc cacaaactct ttaacaactt 300 gaaataaatg tgtggactta agttgcaccc cagtcttcat catctgggca tcagaatatt 360 tccttatggt tttggatgta ccatttgttt cttatttgtg taactgtaag ttcacatcaa 420 cctcatgggt ttggcttgag gctggtagct tctatgtaat tcgcaatgat tccatctaaa 480 <212> Type: DNA <211> Length: 480       SequenceName: # 110       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgttagctc ctcactgtgg taaatgccac acacctttaa gtagataagc agacgatagt 60 tatctgttct tttgacttaa tctcatttgg tttgattttc cctctactaa ggctttccta 120 ccttcttcag gctgcctaag acatgtaagc gaaacacttc aataattgtc catgaggaga 180 aaaaaagcat tgtcatgcat gaaggaaact gaacttgagg tggcctcctt gcttgttaca 240 tacctgggta tgtgtaggca gtttagtgca tctttgcctc tcagttgaaa cctgtataac 300 cctgttacaa agctgtgttg ttgcttcttg tgaaggccat gatattttgt tttttcccca 360 attaattgct attgtgttat tttactaact tctctctgta ttttttcttg cattgacatt 420 atagacattg aggacctcat ccaaacaatt taaaaatgag tgtgaagggg gaacaagtca 480 aaatattttt aaaagatctt caaaaataat gcctctgtct agcatgccaa c 531 <212> Type: DNA <211> Length: 531       SequenceName: # 111       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgccaagcac tcgagaccat cttggcccct ccagaccctg cctgagccta ggagcttgag 60 tcacctcctc cactcactcc agcccaacag aaggaaggag gagggcgccc attcgtctgt 120 cccagagctt attggccact gggtctcgct ccgagtgggg ccagggtggg agggagggtc 180 agggggagga aaggggcgag cacccacgtg agagaatctg cctgtggcct tgcccgccag 240 cctcagtgcc acttgacatt ccttgtcacc agcaacatct cgagccccct agatgtcccc 300 tgtcccacca actctgcact ccatggccac cccgtgccac ccgtaggcag cctctctgct 360 ataagaaaag c 371 <212> Type: DNA <211> Length: 371       SequenceName: # 112       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatctgtgag atgcactgct acctggtact gctttcagtg tgttccccct cagcccctcc 60 ggcgtgtcag gcatactctg agtagataat ttgtcatgca gcgcatgcaa tcagaatctc 120 actgagccac ccatcattgt gaaataatta cctcagttgt acaggacttg gtgatcagga 180 tccaggcact cacttgtatt ctactgctca ataaac 216 <212> Type: DNA <211> Length: 216       SequenceName: # 113       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaaagggag tcgcgtatag aggagagngc gacagtcgcg agccacactt tgcaatgaaa 60 ctctttagac tttctgccgg gagagcggcc cagacgcgcc aggtctgtag caggaggccg 120 nnncgagggc gggtccccag aagcctacag gtgagtatcg gttctcccct tcccggcttt 180 cggtccggag gaggcgggag cagcttccct gttctgatcc tatcgcgggc ggcgcagggc 240 cggcttggcc ttccgtggga cggggagggg ggcgggatgt gtcacccaaa taccagtggg 300 gacggtcggt ggtggaacca gccgggcagg tcgggtagag tataagagcc ggagggagcg 360 gccggg 366 <212> Type: DNA <211> Length: 366       SequenceName: # 114       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtatgacaac ccgggatcgt ttgcaagtaa ctgaatccat tgcgacattg tgaaggctta 60 aatgagttta gatgggaaat agcgttgtta tcgccttggg tttaaattat ttgatgagtt 120 ccacttgtat catggcctac ccgaggagaa gaggagtttg ttaactgggc ctatgtagta 180 gcctcattta ccatcgtttg tattactgac cacatatgct tgtcactggg aaagaagcct 240 gtttcagctg cctgaacgca gtttggatgt ctttgaggac agacattgcc cggaaactca 300 gtctatttat tcttcagctt gccc 324 <212> Type: DNA <211> Length: 324       SequenceName: # 115       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggtctctaa tttcccaaga cttgtatttt ttttttattt caaattataa cacttttttt 60 tcccccagaa gtgggtgttt catgttgcta ctctggtgtg tcccaagata tcctaactgg 120 ccagtgtaaa tgctattctt tctaaataag attatttgga aacttccttc aaactgcagg 180 agggcgagct ctgagggcac gagaagctaa aactagctgc ttttgatgaa aaagagtgcc 240 agtctttggt catctctaaa caaggcttat caccaatgga gacagaaaac tctagttcaa 300 gagctgtacc tcctttgaat cc 322 <212> Type: DNA <211> Length: 322       SequenceName: # 116       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagaggcgaa gccaggtcac ctttcaagga cccagaagta gggttttggc ctaggtaacg 60 gggcagagat gtggttcgag attctccccg gactctccgt catgggcgtg tgcttgttga 120 ttccaggact ggctactgcg tacatccaca ggttcactaa cgggggcaag gaaaaaaggg 180 ttgctcattt tgggtatcac tggagtctga tggaaagaga taggcgcatc tctggagttg 240 atcgttacta tgtgtca 257 <212> Type: DNA <211> Length: 257       SequenceName: # 117       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggcctacat ggaccagcag actggcaacc tcaagaaggc cctgctcctc cagggctcca 60 acgagatcga gatccgcgcc gagggcaaca gccgcttcac ctacagcgtc actgtcgatg 120 gctgcacgag tcacaccgga gcctggggca agacagtgat tgaatacaaa accaccaaga 180 cctcccgcct gcccatcatc gatgtggccc ccttggacgt tggtgcccca gaccaggaat 240 tcggcttcga cgttggccct gtctgcttcc tgtaaactcc ctccatccca acctggctcc 300 ctcccaccca accaactttc cccccaaccc ggaaacagac aagcaaccca aactgaaccc 360 cctcaaaagc caaaaaatgg gagacaattt cacatggact ttggaaaata tttttttcct 420 ttgcattcat ctctcaaact tagtttttat ctttgaccaa ccgaacatga cca 473 <212> Type: DNA <211> Length: 473       SequenceName: # 118       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctccccatt tttataccaa aggtgctaca tctatgtgat gggtggggtg gggagggaat 60 cactggtgct atagaaattg agatgccccc ccaggccagc aaatgttcct ttttgttcaa 120 agtctatttt tattccttga tattttttnt ttnttttttt ttttttttgt ggatggggac 180 ttgtgaattt ttctaaaggt gctatttaac atgggaggag agcgtgtgcg gctccagccc 240 agcccgctgc tcactttcca ccctctctcc acctgcctct ggcttctcag gcctctgctc 300 tccgacctct ctcctctgaa accctcctcc acagctgcag cccatcctcc cggctccctc 360 ctagtctgtc ctgcgtcctc tgtccccggg tttcagagac aacttcccaa agcacaaagc 420 agtttttncc cctaggggtg ggaggaagca aaagactctg tacctatttt gt 472 <212> Type: DNA <211> Length: 472       SequenceName: # 119       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cttctcccct gcaataccat acaggcaatc cacgtgcaca acacacacac acactcttca 60 catctggggt tgtccaaacc tcatacccac tccccttcaa gcccatccac tctccacccc 120 ctggatgccc tgcacttggt ggcggtggga tgctcatgga tactgggagg gtgaggggag 180 tggaacccgt gaggaggacc tgggggcctc tccttgaact gacatgaagg gtcatctggc 240 ctctgctccc ttctcaccca cgctgacctc ctgccgaagg agcaacgcaa caggagaggg 300 gtctgctgag cctggcgagg gtctgggagg gaccaggagg aaggcgtgct ccctgctcgc 360 tgtcctggcc ctgggggagt gagggagaca gacacctggg agagctgtgg ggaaggcact 420 cgca 424 <212> Type: DNA <211> Length: 424       SequenceName: # 120       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtacatatct aactctgttc tcttttggtt gttcagaaac tggatttttt ttttttctta 60 agcagtgctt aatttgtgtt ttttaatttt gattcagaag tagtcccagc tcataggtgt 120 tcataactgt tacatccaga acatttgtca ggctctctgt cagcttttca tgtacatatg 180 gtatagaaac catggagtta ggcacttccc tggaattttt ttttttatga gaaaaatact 240 gtatttaaaa tgtaaaataa acttttaaaa agcaggcact aatatatatt tcttccagcc 300 tttgattaca aatttgtcct tgcacatgtt aagatgaatt atctcctaaa aatatcattg 360 ttcttgggag cagtgtatgt tactttacat agcagcggtt cctgtcatgt gttcatgtt 419 <212> Type: DNA <211> Length: 419       SequenceName: # 121       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgtctcagt ccatttgcgg aggaacattg gtgttacagc agtggcattt aataaggaac 60 ttgatcctat acagaaactc tttgtggaca agattagaga atacaaatct aagcgacaga 120 catctggagg acctgttgat gctagttcag agtatcacca agagctggag agggagcttt 180 ttaagctcaa gcaaatgttt ggtaatgcag acatgaatac atttcccacc ttcaaatttg 240 aagatcccaa atttgaagtc atcgaaaaac cccaggcctg aagaataaag taaaattaat 300 ctggtaattt gtcacggatt agttgtacaa ctacttagaa gtttcagaat aaacatgcat 360 ttcataactg tcaa 374 <212> Type: DNA <211> Length: 374       SequenceName: # 122       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgagcccaa gcacacatgc atggcatttg ttcctgaaca ggagggcatc cctggggatg 60 tggctggagc atgagccagc tctgtcccag gatggtccca gcggatgctg ccaggggcag 120 tgaagtgttt aggtgaagga caagtaggta agaggacgcc ttcaggcacc acagataagc 180 ctgaaacagc ctctccaagg gttttcacct tagcaacaat gggagctgtg ggagtgattt 240 tggccacact gtcaacattt gttagaacca gtcttttgaa agaaaagtat ttccaacttg 300 tcacttgcca gtcactccgt tttgcaaaag gtggcccttc actgtccatt ccaaatagcc 360 cacacgtgct ctctgctgga ttctaaatta tgtgaatttt gccatattaa atcttcctca 420 tttatactat tatttgttac gttcaatcag aatccccgaa acctcctata aagcttagct 480 gccccttctg 490 <212> Type: DNA <211> Length: 490       SequenceName: # 123       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttgaggatc tcttactctc taagccacgg aattaacccg agcaggcatg gaggcctctg 60 ctctcacctc atcagcagtg accagtgtgg ccaaagtggt cagggtggcc tctggctctg 120 ccgtagtttt gcccctggcc aggattgcta cagttgtgat tggaggagtt gtggccatgg 180 cggctgtgcc catggtgctc agtgccatgg gcttcactgc ggcgggaatc gcctcgtcct 240 ccatagcagc caagatgatg tccgcggcgg ccattgccaa tgggggtgga gttgcctcgg 300 gcagccttgt gggtactctg cagtcactgg gagcaactgg actctccgga ttgaccaagt 360 tcatcctggg ctccattggg tctgccattg cggctgtcat tgcgaggttc tactagctcc 420 ctgcccctcg ccctgcagag aagagaacca tgccagggga gaaggcaccc agccatcctg 480 acccagcgag gagccaacta tcccaaatat acctg 515 <212> Type: DNA <211> Length: 515       SequenceName: # 124       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgaatcagcc ataacgcaca cacacgccac ccagcctctt gtttctagta tgtactttga 60 aatgctaact gagggtcttg atgcttgagc ctttgactga taaaactcaa atagcagtcc 120 ccagtgattt gcctcttagg ttctttctta aattgttggt ggatgactgt acattttagt 180 gatttgaaaa ataactgaca aaccattgaa acagtttatt ttatgttgga agagatggcg 240 cagatgtgtg tcagaaggga gatcacggtg tgagtttcgt agctatttaa gtgatacata 300 cctctagttt ttgtatgtct tttgagatcc tgagttcatc ccctgtgaat cagagtgcac 360 aagcacctct cctgtgagtg gctaatgaga agagggacag accgaccacc agcacagtag 420 ggcagatctg gacagcagaa tgttataacg caagttcatg tgttgctccc aactc 475 <212> Type: DNA <211> Length: 475       SequenceName: # 125       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caagttgctt agagagccac cagggtgatt tgctgctggc tttctatcat ttttatgttt 60 taatgcaaag gaaattttaa aatgttctgg aagtgttttt gattaagcaa tgcagcctag 120 aagcaatggt tctgttcaat cattcagatg ttagtggaag cataaaagtc aagactgcat 180 gttgaaacct ttcttttgat agttactgaa ctgcttggtt aaactaaatg gaaccatgtg 240 ctaatttttc acaattattg acctgtattg attgccactg tagtttggta tttcccttta 300 ctttggtggc ctgcttccct catgccctgg aatacaactc agagctccag gcagcggaac 360 catctattgt tttgtttgcc agaaagtgca ccctgtatgg tctcctgtct aagttggaa 419 <212> Type: DNA <211> Length: 419       SequenceName: # 126       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggccactccc aggtaaaatc cagggggaag agtcatctaa gtttaccatg cagttgttta 60 ccaaaaatag aggaggagag tcttaacttt tgctcttgga tttaagtcaa ggtactgtat 120 agaagttgtg taaaatcagt atgaaagttc aatgttgctg ttcttgctca gtgattttaa 180 agaaattgag tagttcctat gtgatttttt tttttctttt ctaaactgca ttcctgtgcc 240 cacctacggc atgcctctat gtattggcta ctacagtgtt ttaaaaagtg tttcagatat 300 ttctctaatt atgtacaacc taaaatgttg gtgttttgta tggatcacaa gtgcagcatt 360 ccttaattcc ttctgctata tgtcacacag ttgttatttg gagaaccaag tatgtattgc 420 atgaaaacat tatgactttt ttctcttagt ttaaataaac tccaaggtaa ctggacttct 480 aaagcacctt tctgtttgcc tgatatctac tttagcaata atttttttta caaccctctg 540 actcaacaa 549 <212> Type: DNA <211> Length: 549       SequenceName: # 127       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccagcgggtc tggggtctat gtgaggatgt ggaagagaca gcagcagaag tgggagcgaa 60 aaattattgg cattttttca gggcaccagt gggtggacat gaatggttcc ccacaggatt 120 tcaacgtggc tgtcagaatc actcctctca aatatgccca gatttgctat tggattaaag 180 gaaactacct ggattgtagg gaggggtgac acagtgttcc ctcctggcag caattaaggg 240 tcttcatgtt cttattttag gagaggccaa attgtttttt gtcattggcg tgcacacgtg 300 tgtgtgtgtg tgtgtgtgtg tgtaaggtgt cttataatct tttacctatt tcttacaatt 360 gcaagatgac tggctttact atttgaaaac tggtttgtgt atcatatcat atatcattta 420 agcagtttga aggcatactt ttgcatagaa ataaaaaaaa tactgatttg gggcaatgag 480 gaatatttga caattaagtt aatcttcacg tttttgcaa 519 <212> Type: DNA <211> Length: 519       SequenceName: # 128       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agtatggcct attctctgta tttatttact agaggagagg ggccactgaa aacttcccag 60 gatttaattc atcaactaga ggtttttgct gcagagggtt taaagcttac ttccagtgtt 120 caagcttttt caaaacagct gaaagacgat gacaagctta tgcttctcct ggaaataaac 180 aagctaattc ctctatgcca ccagctccag acagtaacta agacttcttt gcagaataaa 240 gtatttctaa aggttgacaa gtgtattacg aagacaagat ccatgatggc tctcttagtc 300 caacttcttt cactttgtta taaactgctg aagaagcttc agatggaaaa taacggatgg 360 gtctcagtta caaataagga cactatggat agtaaaactt gagaagcttt tggggtcaga 420 tctctggaac atcatgtgat gaagctgaca tttttaaaaa tcaaatgatc ctttatcttt 480 tcagaaattc atcaatttta taaagaaaac aatattgaaa ttttgctcta ttttctgatc 540 atga 544 <212> Type: DNA <211> Length: 544       SequenceName: # 129       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attacggctt ttctattgct gtatgataca gaactctttt ggcataaata tttgtgttcc 60 cagtacctca cttgttcgga tttgactgcc tgtatatgtt ttgtgaaatg gtcctgtttt 120 tgggtaggtg acacgtggac tctagtatgt aaatgttact tgaatctgtg cttcataata 180 gtgtgtggca tgtatgtgca gactcttgga tgctttatgc ctgcgcacca ggagccctgt 240 cctcacgttc ccaggagggc ggcttcaccc ttcgtaacca ggagacaagg cggccatgga 300 tttgcccttg attctatttt gctaatggaa gatagaaagg agagaaggtt tttttttttt 360 tttaacattc tgaagatggt gctgtgtcaa gaaggacctt ttttttcccc tctcccctat 420 tttttaagta ccttggagga ggagaggttg gtgacatgca tggtggggat ctatggcctc 480 tggtgctttg tcctgtattt ggtttaatgt ttttgtccta atctcttca 529 <212> Type: DNA <211> Length: 529       SequenceName: # 130       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccatggacaa tgcatgccct cgttatcttg aaaagcatac ttccacaggc tgcactcgag 60 gagatccaca aattctcagg aacctacacc tgcatgaaca ctttcaaagg gcggacatag 120 agacaggatg aagacatgct tgaggagcca cggagtttgg gggccacagc acctgggcac 180 acacccgagc acctgtccat tggcatgctt ctgctgggtg agcaggacag ctcctgtccc 240 cagcgaagaa tccggctgcc cctgggccag tcccaggacc tttgcacagg actgatgggt 300 gtaactgacc cccacaggga ggcaggaaaa cagccagaag ccaccttgac acttttgaac 360 atttccagtt ctgtagagtt tattgtcaat tgcttctcaa gtctaaccag cctcagcagt 420 gtgcatagac catttcca 438 <212> Type: DNA <211> Length: 438       SequenceName: # 131       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggagaattc tttaggttgt cccctaaaga ttctgaaaaa gagaatcaga ttcctgaaga 60 ggcaggaagc agtggcttag gaaaagcaaa gagaaaagca tgtcctttgc aacctgatca 120 cacaaatgat gaaaaagaat agaactttct cattcatctt tgaataacgt ctccttgttt 180 accctggtat tctagaatgt aaatttacat aaatgtgttt gttccaatta gctttgttga 240 acaggcattt aattaaaaaa tttaggttta aatttagatg ttcaaaagta gttgtgaaat 300 ttgagaattt gtaagactaa ttatggtaac ttagcttagt attcaatata atgcattgtt 360 tggtttcttt taccaaatta agtgtctagt tcttgctaaa atcaagtcat tgcattgtgt 420 tctaattaca agtatgttgt atttgagatt tgcttagatt gttgtactgc tgccattttt 480 attggtgttt gattattgga atggtgccat attgtcactc cttc 524 <212> Type: DNA <211> Length: 524       SequenceName: # 132       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtattcttac tatggttgcc tttccctatt tgttcaatag actgataata ctggtattta 60 tagagtttga gccattacaa cttttgtgag gatgtgtttc aaacatttct ggacaaatct 120 tattttgtat ttctggaaga atgtagtaat cttctagacc gcttaaaacc aatgctccca 180 agctgaatat tcttgagcaa atttgttttt tattatgcca tttgacattt caaatcagtg 240 ctcatataca gtaaacttgt gatagaaatt gtattttatt gctttttgga ttataattca 300 tataaatata attacttgaa tattgtttga gatcattaac atgccagggc agttcccact 360 gatttagatg gtccaagata atctcattca ggaggcttga aacattaatg gtttagtctt 420 gtgaatttta acagttctct gtcatcgttt aacaaaacca acaactgaca caactcctta 480 agctgtggtt tcagtctctg ctagttcata ttgcatgt 518 <212> Type: DNA <211> Length: 518       SequenceName: # 133       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atatgtattc attcactttc aagatttgtt ttggtgtcaa aataacatga aaaggtagat 60 ggagttgctt ctgttgaatt agctctgcca ccaatatgta tcttcataca cgtttggaaa 120 tgtttcctgc agcattaggt atgacttgtt ctgagtactg cttccggtgc taaaatgaac 180 aaagaatttg tacttaatgg catggactct ggagaatcta tgcgaatcaa cctttctacc 240 ttaatatctc cccaaaaatg tatagtgcct tgtttttatg tacagtttat atacagaaaa 300 gtttgctctg catttttgat gatgg 325 <212> Type: DNA <211> Length: 325       SequenceName: # 134       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggagctgag tgaatatgtt tgttgctact tacaatcccg acctgttagt cccagtagtt 60 ttgttttaac atggtctttt tcaactttgt ttcctgttta actacagatg acttctgttg 120 tagactcaca agtttaactg ttgtattata acagtattac atgtcaacgg tgtggttatg 180 acctttattt atataaaaac cnaatattta gtcaatttac cgtgtcttaa tttaatcttt 240 gtacaccttc catttttaag tgcttaaatg agtactatat tgcaataaaa tgtagtgata 300 taattaacca gccat 315 <212> Type: DNA <211> Length: 315       SequenceName: # 135       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagccatgtt tcgaagacct gtattacagg tacttcgtca gtttgtaaga catgagtccg 60 aaacaactac cagtttggtt cttgaaagat ccctgaatcg tgtgcactta cttgggcgag 120 tgggtcagga ccctgtcttg agacaggtgg aaggaaaaaa tccagtcaca atattttctc 180 tagcaactaa tgagatgtgg cgatcagggg atagtgaagt ttaccaactg ggtgatgtca 240 gtcaaaagac aacatggcac agaatatcag tattccggcc aggcctcaga gacgtggcat 300 atcaatatgt gaaaaagggg tctcgaattt atttggaagg gaaaatagac tatggtgaat 360 acatggataa aaataatgtg aggcgacaag caacaacaat c 401 <212> Type: DNA <211> Length: 401       SequenceName: # 136       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccacgtacct caggctcatg tacagtcagg aatggttcct tctcatccaa ctgcccatgc 60 gccaatgatg ctaatgacga cacagccacc cggcggtccc caggccgccc tcgctcaaag 120 tgcactacag cccattccag tctcgacaac agcgcatttc ccctatatga cgcacccttc 180 agtacaagcc caccaccaac agcagttgta aggctgccct ggaggaaccg aaaggccaaa 240 ttccctcctc ccttctactg cttctaccaa ctggaagcac agaaaactag aatttcattt 300 attttgtttt taaaatatat atgttgattt cttgtaacat ccaataggaa tgctaacagt 360 tcacttgcag tggaagatac ttggaccgag tagaggcatt taggaacttg ggggctattc 420 cataattcca tatgctgttt cagagtcccg caggtacccc agctctgctt gccgaaactg 480 gaagttattt attttttaat aacccttgaa agtcatgaac acatcagcta gc 532 <212> Type: DNA <211> Length: 532       SequenceName: # 137       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagccaggat tctccggtct ggaatttctg agtgagtcct ttttttatgg tgtcctccct 60 ctgtgaatgt acaggcggaa ctgtacgaac agctcccttc catccatttt taactctttc 120 ggaaataaca cctcacagca gcttcgtgct tttgtacaga cctttgtaac aagtgtacag 180 aaaactcatt ttgtttgaga aacaggagtt gatgaaccca tcatgctggt ttttctctga 240 gcacaaagtt ttaggctgta cacagccagc cttgggaatc tcgttgagcg ttcggcgtgg 300 atccacgggg ccaggccacc ctgcgggagg ccacacgcat ccacttcgga ttcagtgggt 360 gaagacagaa ctctgagagt ctgcaggcgg ctcctgtgct ttttatttct ggctcttcgg 420 atgtcttcta gacatttact atcactgcac ctgaagaaaa aatcactttt accttcctaa 480 tttaaaaaga caaaacagaa atgtacgttc cttcgctagc 520 <212> Type: DNA <211> Length: 520       SequenceName: # 138       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgcacgatg cctggagtta ctgtaaaaga cgtgaaccag caggagttcg tcagagctct 60 ggcagccttc ctcaaaaagt ccgggaagct gaaagtcccc gaatgggtgg ataccgtcaa 120 gctggccaag cacaaagagc ttgctcccta cgatgagaac tggttctaca cgcgagctgc 180 ttccacagcg cggcacctgt acctccgggg tggcgctggg gttggctcca tgaccaagat 240 ctatggggga cgtcagagaa acggcgtcat gcccagccac ttcagccgag gctccaagag 300 tgtggcccgc cgggtcctcc aagccctgga ggggctgaaa atggtggaaa aggaccaaga 360 tggcggccgc aaactgacac ctcagggaca aagagatctg gacagaatcg ccggacaggt 420 ggcagctg 428 <212> Type: DNA <211> Length: 428       SequenceName: # 139       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaataatcag ccgtggggcc aattttttaa ctcagatctt gctgagacca ggagcatctg 60 atttaacagg aagtttcaga ttataccgaa aagaagttct agagaaatta atagaaaaat 120 gtgtttctaa aggctacgtc ttccagatgg agatgattgt tcgggcaaga cagttgaatt 180 atactattgg cgaggttcca atatcatttg tggatcgtgt ttatggtgaa tccaagttgg 240 gaggaaatga aatagtatct ttcttgaaag gattattgac tctttttgct actacataaa 300 agaaagatac tcatttatag ttacgttcat ttcaggttaa acatgaaaga agcctggtta 360 ctgatttgta taaaatgtac tcttaaagta taaaatataa ggtaaggtaa atttcatgca 420 tctttttatg aagaccacct attttatatt tcaaattaaa taattttaaa gttgctggcc 480 taatgagcaa tgttctcaat tttcgttttc a 511 <212> Type: DNA <211> Length: 511       SequenceName: # 140       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagagacatc agcccttggg ggtcctcctc cagggacagc aactatcaga ctaagccagc 60 accggaccag cctggcccac cccacccact tctgcacttg cggttccggc atggacaatg 120 gaccggagag tgggggtggg gggtcccaaa gagtttgatg aggccctcca cacctgcggc 180 ccaatccaag gtggggtg 198 <212> Type: DNA <211> Length: 198       SequenceName: # 141       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agagcttcct gatctgggtg aatgaggagg atcatacacg ggtgatctcc atggagaagg 60 gtggtaacat gaagagagtg tttgaaagat tctgccgagg cctcaaagag gtggagagac 120 ttatccaaga acgtggctgg gagttcatgt ggaatgagcg tttgggatac atcttgacct 180 gtccatctaa cctgggcact ggacttcggg caggagtgca catcaaactg cccctgctaa 240 gcaaagatag ccgcttccca aagatcctgg agaacctaag actccaaaaa cgtggtactg 300 gaggagtgga cactgctgct acaggcggtg tctttgatat ttctaatttg gaccgactag 360 gcaaatcaga ggtggagctg gtgcaactgg tcatcgatgg agtaaactat ttgattgatt 420 gtgaacggcg tctggagaga ggccaggata tccgcatccc cacacctgtc atccacacca 480 agcattaact ccccatcgcc agctgatgac tcaagattcc caggagtttt gctcattcta 540 atgatggccc attctacttg ctc 563 <212> Type: DNA <211> Length: 563       SequenceName: # 142       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acgtcatgat gggccctaat tcggtcatgt caacctatgg cagccaggca tctcataaca 60 aaatgatgaa tcccagctcc catacccacc ctggacatgc tcagcagaca tctgcagtta 120 acgggcgtcc cctgccccac acggtaagca ccatgcccca cacctcgggt atgaaccgcc 180 tgacccaagt gaagacacct gtacaagtgc ctctgcccca ccccatgcag atgagtgccc 240 tggggggcta ctcctccgtg agcagctgca atggctatgg cagaatgggc cttctccacc 300 aggagaagct cccaagtgac ttggatggca tgttcattga gcgcttagac tgtgacatgg 360 aatccatcat tcggaatgac ctcatggatg gagatacatt ggattttaac tttgacaatg 420 tgttgcccaa ccaaagcttc ccacacagtg tcaagacaac gacacatagc tgggtgtcag 480 gctgagggtt agtgagcagg ttacacttaa aagtacttca gattgtctga cagcaggaac 540 tgagagaagc agtccaaaga tgtctttcac caactccc 578 <212> Type: DNA <211> Length: 578       SequenceName: # 143       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagcagtaaa tcaatggaac atcccaagaa gaggataagg atgcttaaaa tggaaatcat 60 tctccaacga tatacaaatt ggacttgttc aactgctgga tatatgctac caataacccc 120 agccccaact taaaattctt acattcaagc tcctaagagt tcttaattta taactaattt 180 taaaagagaa gtttcttttc tggttttagt ttgggaataa tcattcatta aaaaaaatgt 240 attgtggttt atgcgaacag accaacctgg cattacagtt ggcctctcct tgaggtgggc 300 acagcctggc agtgtggcca ggggtggcca tgtaagtccc atcaggacgt agtcatgcct 360 cctgcatttc gctacccgag tttagtaaca gtgcagattc cacgttcttg ttccgatact 420 ctgagaagtg cctgatgttg atgtacttac agacacaaga acaatctttg ctataa 476 <212> Type: DNA <211> Length: 476       SequenceName: # 144       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatgccaagg ccacaaaagc caagagcaag aagaactgag gagtggtgga ccaggctcga 60 acactggccg aggaggagct ctctgcctgc cagaagagtc tagtcctgct cccacagttt 120 ggagggacaa agctaattga tctgtcacac tcaggctcat gggcaggcac aagaagggga 180 ataaaggggc tgtgtgaagg cactgctggg agccattaga acacagatac aagagaagcc 240 aggaggtcta tgatggtgac ga 262 <212> Type: DNA <211> Length: 262       SequenceName: # 145       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcagccagca caatgtgacc caacttaaaa tttgggggaa aaagaatgca ggagtgaaat 60 aaccaagtca aaaccatgta ctatctcctt gggggttagg gatgctaaga agagcccaca 120 aatagaggat tactcttccc ctgaatctct aaactcagaa acaattacca aaaaatacat 180 aactcttcct tgtagggccc tttccttatt catttaggta gtgtgaacat taagtataaa 240 ataaattatg ttcttaatgc ctcttaaacc acttacattc aaaggggaac agaaatcatt 300 ctaagcagga aaatacttcc actttttttt tttcaagtat ctctctaata actaaatgcc 360 acttatttgc attctccttg tggatttttt gtcacctaag gaaatgcatt tgatgagtgc 420 tggaaacttc ttaagtgctt tacagtttgt tttcattgtt tgcagcggat cactggacat 480 caaagattca ttgcacttat gaacaaggaa ccttcttttc aatttctgtg taatttgcaa 540 ggctgtacaa tgtgtgctga tgcaagcctt t 571 <212> Type: DNA <211> Length: 571       SequenceName: # 146       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagtattgca ttctgccgtg tttataggtg ttcactttcc tccagagctg attaactact 60 gacatgactt ggctttctca tccagaaatt atggaaacag ggtctgtcag tggcaggagg 120 ccgtgctgtg ttttacttgg atgacacaat gcagtttact tgcctcttca tacccatgca 180 tgctngctca ccctagacaa tgacatataa gccgtatata gatcaatgtc cacatatata 240 tacacacaca natatatata tataaagtgt aancaaggaa cactaaaaca gtgttgattc 300 ttgtctctga a 311 <212> Type: DNA <211> Length: 311       SequenceName: # 147       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagatactat ttttgctgag caaccagtgt gtttcaggat gatacaaaga aaaatataga 60 atagaaataa gtgcaggctt ggaatcagct acaaatccta aagatggggt gtgtgtggat 120 gtgtgtgtgt gtgtgtgtac accattgtgt gtttgtaaaa tgtgtatgtt catgagtaag 180 ggtgtgtgtg tgtgtgtatt aaaattccag agtgaccgtg gcacttgggt gtacaggtaa 240 ttcctccaga gctgtttgct ggcttcagga gtggagtgag aatttctttt ttatgaaaag 300 ggatataaag gcaccgagct gatgcagtat ttgtaatatt aagttgacct aacaaggtat 360 ttgcatgagt cacaattaca aagttttgag cggttttgta atttgacatt taggaaagtc 420 tcctatttat tctcatactt tacattcatg cttagtatac tatagaggat gccagcttta 480 atctttctg 489 <212> Type: DNA <211> Length: 489       SequenceName: # 148       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgagcagtgg tgtccatcac atatattata gaagcaagcg agcacattcc accctagaaa 60 tggttcagaa actcataggc acccttagct gatggaaaca atcaatcata tttaatacgc 120 ttagaatcag ttttactcca atcagctggc aattttgagc tgccggttat acaccaaaat 180 gttctgttca gtacctagct ctgctctttt atattgcttt aaatttttaa agaaattata 240 ttgcatggat gtggttattt gtgcatattt tttaacaatg cccaatctgt atgaataatg 300 taaacttcga ttttttttta aaaaaattag attttagctg gagcttttga ctaatgtaaa 360 gtaaatgcca aactaccgac ttgataggga tgtttttgta agttaatttt ctaagacttt 420 ttcacatcca aagtgatgct ttgctttggg ttttaactgt ttggccacgg cgggggtggg 480 ggcggggggt tggtacagaa acttgaagct gtttgtgata tgtacaactc agatgtttct 540 catt 544 <212> Type: DNA <211> Length: 544       SequenceName: # 149       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aactaagtta tttactcctc ctgctcctca cccctgtagg gaaaccttgg agaggagagt 60 ggcaggtggg ctgcctgctg tgttaagagg acttagtttg tgatgtaagg cactgtcagg 120 aatggggggc gggccagggt gggaagagaa gaaatagcag agcctatttt ggtgaggttt 180 tttgttttta agtcaaagaa gactcagtat gctttccctg aggaatgaaa aagggattga 240 ggagttgcct gactcctggg tgggtggggt acaggcagtt aggtgctgaa tgaagctgcc 300 atccttgctg cagcttctaa ctggtaaaaa gatccaggga tggagatggg aaggttagaa 360 aggcagccct cacctctgag gacagaggcc ggggtccagg cccgtgggcg caaaggtgcc 420 tcatagcata gccagcattc agcacacaca aacctactgc ccacatttgg gctcagggtt 480 ggccatttgc ta 492 <212> Type: DNA <211> Length: 492       SequenceName: # 150       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatagcctg aacctgggaa tcggaggttg cagggccaag atcgccccac tgcactccag 60 cctggcaata gaccgagctc cgtctccaaa aaaaaaaata caatttttat ttcttttact 120 ttttttagta agttaatgta tataaaaatg gcttcggaca aaatatctct gagttctgtg 180 tattttcagt caaaacttta aacctgtaga atcaatttaa gtgttgaaaa aaatttgtct 240 gaaacatttc ataatttgtt tccagcatga ggtatctaag gatttagacc agaggtctag 300 attaatactc tatttttaca tttaaacctt ttattataag tcttacataa accatttttg 360 ttactctctt ccacatgtta ctggataaat tgtttagtgg aaaataggct ttttaatcat 420 gaatatgatg acaatcagtt atacagttat 450 <212> Type: DNA <211> Length: 450       SequenceName: # 151       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctgtgaagg acctgatgcc atgtatgtca aattgatatc atctgatggc catgaattta 60 ttgtaaaaag agaacatgca ttaacatcag gcacgataaa agccatgttg agtggcccag 120 gtcagtttgc tgagaacgaa accaatgagg tcaattttag agagatacct tcacatgtgc 180 tatcgaaagt atgcatgtat tttacgtaca aggttcgcta cactaacagc tccaccgaga 240 ttcctgaatt cccaattgca cc 262 <212> Type: DNA <211> Length: 262       SequenceName: # 152       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaggccagca gcagataaca accccggaca aatcagcgat gtgtcacccc cagtctccca 60 ccttttcttc taatgagtcg actttgagct ggaaagcagc cgtttctcct tggtctaagt 120 gtgctgcatg gagtgagcag tagaagcctg cagcggcaca aatgcacctc ccagtttgct 180 gggtttattt tagagaatgg gggtggggag gcaagaacca gtgtttagcg cgggactact 240 gttccaaaaa gaattccaac cgaccagctt gtttgtgaaa caaaaaagtg ttcccttttc 300 aagttgagaa caaaaattgg gttttaaaat taaagtatac atttttgcat tgccttcggt 360 ttgtatttag t 371 <212> Type: DNA <211> Length: 371       SequenceName: # 153       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcccggcagg acctgcaggg gacgagccag ccgagagccc atcggagacc ccaggccccc 60 gcccggcagg acctgcaggg gacgagccag ccgagagccc atcggagacc ccaggcccca 120 gcccggcagg acctacaagg gatgagccag ccaaggcggg ggaggcagca gagttgcagg 180 acgcagaggt ggagtcttct gccaagtctg ggaagcctta aggaaaggag tgcccgtcgg 240 cgtcttggtc ctcctgtccc tgctgcaggg gctggggcct ccggagctgc tgcgggctcc 300 cctcaggctc tgcttcgtga cccgtgaccc atgacccaca gtgctggcct cctgtggggc 360 cactatagca gccaccagaa gccgcgaggc cctcagggaa gcccaaggcc tgcagaagcc 420 tcctggcctg gctgtgtctt ccccacccag ctctcccctg cgcccctgtc tttgtaaatt 480 gacccttctg gagtgggggg cggcgggcag ggctgctttt cttagtctga tgcc 534 <212> Type: DNA <211> Length: 534       SequenceName: # 154       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgtggaaac tgcagcgaca gcgaggaaga gctccccacc cgcctctagc ccccagcccg 60 aggcccccac cagcagttgg cggtagcagc tactccgagc gccgtttaca gttttgcaca 120 gtgatcttcc ccattgtcca ctcaagtcgt ggcctgggga acacagacgg agctgtcccc 180 agtgtcctcc gtccctcagc ccctggcctg gctgagtttg gcagggcctg ggccatccct 240 gggacaaagg tgcgtccctt cagctcttct ccgtggagct cggggctttc tgtatttatg 300 tattt 305 <212> Type: DNA <211> Length: 305       SequenceName: # 155       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggagtccta ttgacatcgc cagtaaaatt atcaatgttc tagttctgtg gccatctgct 60 tagtagagct ttttgcatgt atcttctaag aattttatct gttttgtact ttagaaatgt 120 cagttgctgc attcctaaac tgtttatttg cactatgagc ctatagacta tcagttccct 180 ttgggcggat tgttgtttaa cttgtaaatg aaaaaattct cttaaaccac agcactattg 240 agtgaaacat tgaactcata tctgtaagaa ataaagagaa gatatattag ttttttaatt 300 ggtattttaa tttttatata tgcaggaaag aatagaagtg attgaatatt gttaattata 360 ccaccgtgtg ttagaaaagt aagaagcagt caattttcac atcaaagaca gcatctaaga 420 agttttgttc tgtcctggaa ttattttagt agtgtttcag taatgttgac tgtattttcc 480 aacttgttca aattattacc agtgaatctt tgtcagcag 519 <212> Type: DNA <211> Length: 519       SequenceName: # 156       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatgcagagc tactgagcct ttgccctgaa tgggaggtag ggatgtcatt ctccaccaat 60 aatggtccct cttccctgac gttgctgaag gagcccaagg ctctccatgc ctttctacct 120 aagtgtttgt attttatttt aaattattta ttctggagcc acagccccct tgcttatgag 180 gttcttatgg agagtgagaa agggaaggga aatagggcac catggtccgg tggtttgtag 240 ttccttcaaa gtcaggcact gggagctaga ggagtctcaa gctcccctta ggaagaactg 300 gtgccccctc cagtcctaat ttttcttgcc tgccccgcct tggggaatgc ctcacccacc 360 caggtcctga cctgtgcaat aaggattgtt ccctgcgaag ttttgttg 408 <212> Type: DNA <211> Length: 408       SequenceName: # 157       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agccaaggga gctctcactg gaggaacaga ggtgtctgca cttccatgta caacaaacgc 60 tccgggaaat ggaaagccag ttggcagccc acatgtggtt acctcacacc agtcaaaagt 120 gacagtggag agcactcccg atttggaaaa acaaccaaat gaaaatggtg tatctgttca 180 gaatgaaaat tttgaagaaa ttataaactt acccattgga tctaaaccat ccagattaga 240 tgtcaccaac agtgagagcc cagaaattcc tttgaatcca attttggcct ttgatgatga 300 agggacactt gggcccctgc ctcaggtaga tggtgttcag acacagcaga ctgcagaagt 360 tatatgagtg tttcttctga agaaccaaag ctgaaattta atgagaattt ctacaattaa 420 tggaattcct ttcctgctat aaaggagcat cccctccacc cgttttctag agttcttga 479 <212> Type: DNA <211> Length: 479       SequenceName: # 158       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatgatggaa tgttgactgt gtttggcaca caggacacgg accttcatgg aagtccttgc 60 tctgcgtggc atctgtcagc ttttcacctt tcattcttat tcttcacttt tgctgctgag 120 cctagctgta caaacttgca ctttcatttg ctaatataaa ttcagtttta ttttaccatt 180 ttagagacta ctaatgatta aatgtagaag gagagggtgc acatgttttt atgtggagtg 240 tttaaaagat aaatttatac cactgtaatg tgcagctttt attaaaagag aaattggttg 300 aactgctagg ttgaatgaga gacttcatct attggactat tttttttaat ccaggcatat 360 ggtctttagt aatggcttgt aatttgtgaa aacattaatt tgggggtttt ccctgttttc 420 agttgtccat gtacacatag tcattatatt agaaaagaaa gctgttcaac aaacttgttt 480 aatttgttta aatcaacata gcatgaaaca ccaaat 516 <212> Type: DNA <211> Length: 516       SequenceName: # 159       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgccctcca agatgctggt gatagcagca gaaaggagta ctttatttga gggacaacag 60 acttcacttc cctgaatgcc tcccccatct ccatcaggaa aaatacaccc catcgcccag 120 cacccctgct gataccacca gacagagaga gagagcactt gattcttccc gagatagcca 180 cctggaaaca ctaggtgcct gcccagggag gaacggagga ggactcgcgc tacaagaggc 240 cactcccagg gacccaggga ggcgatggcc accccagagg ccaccttttg ctccaccgga 300 ggtgggagaa aatctgggca cgatcgggcc ccctgggcag tgcaggacaa catcagctca 360 ctggcaggaa agtccttgtt gagggtgagg gggtgctggg gtacccgggg gctggggaag 420 caaggaaata agtcatctgt atgctgactg gggataatgg catcaaatgt cagtcnttga 480 catttggggg gaacagcagg tgccagagct aa 512 <212> Type: DNA <211> Length: 512       SequenceName: # 160       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtggcataac gactgcttta actgtaagaa gtgctccctc tcactggtgg ggcgtggctt 60 cctcacagag agggacgaca tcctgtgccc cgactgtggg aaagacatct gaattcaaca 120 cagagaagtt gctgcttgtg atctcacaca cagattttta tgttttcttt ctcacccagg 180 caatcttgcc ttctggtttc ttccagccac attgagactt tcttctagtg cttttcagtg 240 atactcacgt ttgcttaaac cctttagtgc tttgtgatag ttcagtccca gggaaagaga 300 aaactcgccc taggccctag gtgggaagat ggtttgaaat ttttgtaatc gagtaaggca 360 cacccaaatg taaaaatcct tttgaatgat gcctttataa atctttctct cactgtctat 420 ttaagtgcaa ttaacatatg tcacgaactt gaaagttttc taaactcaat aaggtaatga 480 ccagttgtta tttacagctc tgtaacctcc cgttgcgtca agtctaaacc aa 532 <212> Type: DNA <211> Length: 532       SequenceName: # 161       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgatgagctt tcctttgatc cggacgacgt aatcactgac attgagatgg tggacgaggg 60 ctggtggcgg ggacgttgcc atggccactt tggactcttc cctgcaaatt atgtcaagct 120 tctggagtga ctagagctca ctgtctactg caactgtgat ttcccatgtc caaagtggct 180 ctgctccacc ccctccctat tcctgatgca aatgtctaac cagatgagtt tctggacaga 240 cttccctctc ctgcttcatt aagggcttgg ggcagagaca gcatggggaa ggaggtcccc 300 ttccccaaga gtcctctcta tcctggatga gctcatgaac atttctcttg tgttcctgac 360 tccttcccaa tgaacacctc tctgccaccc caagctctgc tctcctcctc tgtgagctct 420 gggcttccca gtttgtttac ccgggaaagt acgtctagat tgtgtggttt gcctcattgt 480 gctatttgcc cactttcctt ccctgaagaa atatctgtga accttctttc tgttcagtcc 540 ta 542 <212> Type: DNA <211> Length: 542       SequenceName: # 162       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttcatcctgt ctgtgttatg tgggtggaga tggttttcat tctttcatta ctgttttgtt 60 ttatcctttg tatctgaaat acctttaatt tatttaatat ctgttgttca gagctctgcc 120 atttcttgag tacctgttag ttagtattat ttatgtgtat cgggagtgtg tttagtctgt 180 tttatttgca gtaaaccgat ctccaaagat ttccttttgg aaacgctttt tcccctcctt 240 aatttttata ttccttactg ttttactaaa tattaagtgt tctttgacaa ttttggtgct 300 catgtgtttt ggggacaaaa gtgaaatgaa tctgtcatta taccagaaag ttaaattctc 360 agatcaaatg tgccttaata aatttgtttt catttagatt tcaaacagtg atagacttgc 420 cattttaata cacgtcattg gagggctgcg tatttgtaaa tagcctgatg ctcatttgga 480 aaaataaacc agtgaacaat atttttctat tgtacttttc agaaccattt tgtctcatta 540 ttcctgt 547 <212> Type: DNA <211> Length: 547       SequenceName: # 163       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaaacatcc ggcaagactt ctgaaaagac aatttagcag gtagaagaaa agttgggctt 60 tcacaaaagg catctgaact tttaatgaac tgtgaaggac aacagcatct tcccaaaacc 120 attgatgttt aagtgtttag aaatcataga aggtgtaggc tgctgtggta attctatttg 180 tatatctcaa cagaattaaa atgtctagct tggtggtatt tttatagcca taaaagaaaa 240 tctttaggct ttcaaaataa ggatgacttt agaataatat tgtgtcatag aattaatttt 300 cagccatgtg gaccatattt tgtatccaag gatccttatt taaagctttc aacatgtaca 360 ggaagttgga aatttttggt ttatgacttt gtctaataaa gagatagttc taaacacatt 420 cttgatcacc a 431 <212> Type: DNA <211> Length: 431       SequenceName: # 164       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgggacaag gagtgcaggc cgcacaacct cggcaggcac cggggggatg tggcgattct 60 acacagaaga ttcacctggg ctcaaagttg gccctgttcc agtattggtt atgagtcttc 120 tgttcatcgc ttctgtattt atgttgcaca tttggggcaa gtacactcgt tcgtagattc 180 agttacat 188 <212> Type: DNA <211> Length: 188       SequenceName: # 165       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcgatagag gcacaacaga agttcaaaat aaataagcaa cacgctagaa gggtttatga 60 aattcttcga ctactggtaa ctgacatgag tgatgccgaa caatacagaa gctacagact 120 ggatattaaa agaagactaa ttagcccata taagaaaaag cagagagatc ttgctaagat 180 gagaaaatgt ctcagaccag aagaactgac aaaccagatg aaccaaatag aaataagcat 240 gcaacatgaa cagctggaag agagttttca ggaactagtg gaagattacc ggcgtgttat 300 tgaacgactt gctcaagagt aaagattata ctgctctgta caggaagctt gcaaattttc 360 tgtacaatgt gctgtgaaaa atctgatgac tttaatttta aaatcttgtg acattttgct 420 tatactaaaa gttatctatc tttagttgaa tattttcttt tggagagatt gtatatttta 480 aaatactgtt tagagtttat gagcatatat tgcatttaaa gaaagataaa gcttctgaaa 540 tactactgca attgcttccc ttc 563 <212> Type: DNA <211> Length: 563       SequenceName: # 166       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctcctccag ggtgatttta tgatcagtgt tgttgctcta ggaagacatt tttccgtttg 60 cttttgttcc aatgtcaatg tgaacgtcca catgaaacct acacactgtc atgcttcatc 120 attccctctc atctcaggta gaaggttgac acagttgtag ggttacagag acctatgtaa 180 gaattcagaa gacccctgac tcatcatttg tggcagtccc ttataattgg tgcatagcag 240 atggtttcca catttagatc ctggtttcat aacttcctgt acttgaagtc taaaagcaga 300 aaataaagga agcaagtttt cttccatgat tttaaattgt gatcgagttt taaattgata 360 ggagggaaca tgtcctaatt cttctgtcct gagaa 395 <212> Type: DNA <211> Length: 395       SequenceName: # 167       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaactgcgtt aaaggctcga ttttgtatct gcaggcagac acggatctga gaatctttat 60 tgagaaagag cacttaagag aatattttaa gtattgcatc tgtataagta agaaaatatt 120 ttgtctaaaa tgcctcagtg tatttgtatt tttttgcaag tgaaggttta caatttacaa 180 agtgtgtatt aaaaaaaacc caaagaaccc aaaaatctgc agaaggaaaa atgtgtaatt 240 ttgttctagt tttcagtttg tatatacccg tacaacgtgt cctcacggtg ccttttttca 300 cggaagtttt caatgatggg cgagcgtgca ccatcccttt ttgaagtgta ggcagacaca 360 gggacttgaa gttgttacta actaaactct ctttgggaat gtttgtctca tcccattctg 420 cgtcatgctt gtgtgataac tactccggag acagggtttg gctgtgtcta aactgcatta 480 ccgc 484 <212> Type: DNA <211> Length: 484       SequenceName: # 168       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggagaactg cttttacctg tggccatgtc agagaaagat tttaagaaag agcaaggagt 60 gctaacagga atgaatgaaa cttctgctgt aatcattgct gcaccacaga atttcactcc 120 ctctgtgatc tttcagaagg ttgtaaatgt agccaatgta ggtgcagtcc cttctggcca 180 ggataatata cacaggtttg cagctaaaac tgtgcacagt gggtcattga tgctagtcac 240 agtggaactg aaggaaggct ctacagccca gcttatcata aacactgaga aaactgtgat 300 tggctctgtt ctgctgcggg aactgaagcc tgtcctgtct caggggtaac ctgcttacat 360 ctggacttta gaatctggca cacaacaaaa gtgcctggca tccactactg ctgcctttca 420 tttataataa tagcccttcc atctggcagt gggggaagaa tacactcttg acattcttgt 480 ctcctgcttt agaatgctag tgtgtatcta tcatgtatgc aatactttcc ccct 534 <212> Type: DNA <211> Length: 534       SequenceName: # 169       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggaggcctt atagatgtgc ttgggggaaa atgaagggga gaaagtagcc atacaggagt 60 tcaaagaatt ccatgccctt cagattagcc caattaccag aaacatcatg aaagatattt 120 taaaaactaa ttatttacta cagtgtattt cacttgtctt gtgtgtctga acacacagaa 180 gctaattagc aagtttttaa gaagtattta aaaatcttac taggattgac attttttctg 240 aattctgtat aaatagctta tagtgagaag tactgtgctc aaattttaca tttttttcct 300 ttgcaaattc tgtaatttca ctcaacgatt aagtctacca aagaacacac tgcatgtaaa 360 agatgtatta caatctcaaa gccagtaaaa gaaatcttgc ttcactgttc acctgctaca 420 agtaagagtt tggtgctggt agaa 444 <212> Type: DNA <211> Length: 444       SequenceName: # 170       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgctaagttc aagtttcgta atgctttgaa gtatttttat gctctgaatg tttaaatgtt 60 ctcatcagtt tcttgccatg ttgttaacta tacaacctgg ctaaagatga atatttttct 120 actggtattt taatttttga cctaaatgtt taagcattcg gaatgagaaa actatacaga 180 tttgagaaat gatgctaaat ttataggagt tttcagtaac ttaaaaagct aacatgagag 240 catgccaaaa tttgctaagt cttacaaaga tcaagggctg tccgcaacag ggaagaacag 300 ttttgaaaat ttatgaacta tcttattttt aggtaggttt tgaaagcttt ttgtctaagt 360 gaattcttat gccttggtca gagtaataac tgaaggagnt gcttatcttg gctttcgagt 420 ctgagtttaa aactacacat tttgacatag tgtttattag cagccatc 468 <212> Type: DNA <211> Length: 468       SequenceName: # 171       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taatgttgtc tgaatttacc acctttgtca gaagtcaact caaagcttcc aatgtagtca 60 gtctataatt ccttaatcaa agtcagcaat ttatggacag cttcagcatt tacagttgac 120 ctttcactag ccaggcaaac ttccc 145 <212> Type: DNA <211> Length: 145       SequenceName: # 172       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttcctgcag aaggcgctcg agatccttcg gaaagacttc agtgagctga ggtccgcagg 60 ggtggagcag ctcatgtaca tcaaggagga cttgatcatc cctcaccatc acagcttcta 120 cgacttcatc gtcaccaagg cacgggggaa gagtggacca ctcttcaact ttgatgttca 180 tgacgatgtg cggttgctca gtgacgccac tgtggagaag gatgagtccc atgcaggcaa 240 ggtggtgctg aggagctggt acgagaagaa caagcacatc tttcccgcca gccgctggga 300 accctacgac cctgaaaaga agtgggacaa gtacacgatc cgctgagcat ccaggaggct 360 gcgcggcccc ggctcctcag ctccctcagt gtgccccgtg gtgtcaccgg gactccaggc 420 acccgctccc ctgcgaccat gccaggcacg ctgggaggag 460 <212> Type: DNA <211> Length: 460       SequenceName: # 173       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctgtggatc tgtttggcca gggtccctgg ggtcaggaat atttgcaaga ctcagccagc 60 tccttcccag cccagcctct tggggctggg actttctcac cctgcggcag gcacaacaga 120 tgctgggacc cagtctctgc ccaggtcaca gcacaagtgc acatcagcac tatggggcct 180 atgtcctgcc cagagacctc tgctccttcc tgctcacatc cacagtcagg gcacggcgcc 240 cctcaagaac tccagagtca cctgtctcat cggctcccaa caagtgcctc tttgtctatg 300 atgtccccct tctctgaggc ctggacccac ccatctttgt ccctgggggc tgctcccagc 360 cactgaggcc cgctctggcc aggggagaag gagctgccgt gcgtcttccc tgtgccccgt 420 ctccctgctt ggttctcccc tcccttccct ggccggctgc catggccagg agctaagtgc 480 ctttttgtgt gcaaccactt accct 505 <212> Type: DNA <211> Length: 505       SequenceName: # 174       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgtggccag ggtcagaaag tgcagaaggt tatggtgcag cccatcaacc tcatcttcag 60 atacttacaa aatagatcgc ggattcaggt gtggctctat gagcaagtga atatgcggat 120 agaaggctgt atcattggtt ttgatgagta tatgaacctt gtattagatg atgcagaaga 180 gattcattct aaaacaaagt caagaaaaca actgggtcgg atcatgctaa aaggagataa 240 tattactctg ctacaaagtg tctccaacta gaaatgatca at 282 <212> Type: DNA <211> Length: 282       SequenceName: # 175       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acaagaagcc tgttctgtcc agcttcagtg acacaagctg ctttagctaa agtcccgcgg 60 gttccggcat ggctaggctg agagcaggga tctacctggc ttctcagttc tttggttgga 120 aggagcagga aatcagctcc tattctccag tggagagatc tggcctcagc ttgggctaga 180 gatgccaagg cctgtgccag gttccctgtg ccctcctcga ggtgggcagc catcaccagc 240 cacagttaag ccaagccccc caacatgtat tccatcgtgc tggtagaaga gtctttgctg 300 ttgctcccga aagccgtgct ctccagcctg gctgccaggg agggtgggcc tcttggttcc 360 aggctcttga aatagtgcag ccttttcttc ctatctctgt ggctttcagc tctgcttcct 420 tggttattag gagaatagat gggtgatgtc tttccttatg tt 462 <212> Type: DNA <211> Length: 462       SequenceName: # 176       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaatgatact tactgaactg tgtgtaattg ttcctttatt tttttggtac ctatttgact 60 taccatggag ttaacatcat gaatttattg cacattgttc aaaaggaacc aggaggtttt 120 tttgtcaaca ttgtgatgta tattcctttg aagatagtaa ctgtagatgg aaaaacttgt 180 gctataaagc tagatgcttt cctaaatcag atgttttggt caagtagttt gactcagtat 240 aggtagggag atatttaagt ataaaataca acaaaggaag tctaaatatt cagaatcttt 300 gttaaggtcc tgaaagtaac tcataatcta taaacaatga aatattgctg tatagctcct 360 tttgaccttc atttcatgta tagttttccc tattgaatca gtttccaatt atttgacttt 420 aatttatgta acttgaacct atgaagcaat ggatatttgt actgtttaat gttctgtga 479 <212> Type: DNA <211> Length: 479       SequenceName: # 177       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctttcctgcc gtgagaaact cgaggtgacc aacctccgtt tccggttggc tccggttgca 60 gagttgagtg tcctgagagg tcagattgct gtcagacatg gcccatgaac atggacatga 120 gcatggacat cataaaatgg aacttccaga ttatagacaa tggaagatag aagggacacc 180 attagaaact atccagaaga agctggctgc aaaagggcta agggatccat ggggccgcaa 240 tgaagcttgg agatacatgg gtggctttgc aaagagtgtt tccttttctg atgtattctt 300 taaaggattc aaatggggat ttgctgcatt tgtggtagct gtaggagctg aatattacct 360 ggagtccctg aataaagata agaagcatca ctgaagataa tacctggaag catcatagtg 420 gtttcttaac tctccaaaat aagatttctt ctctgtagcc tacttgtctg gtttatcc 478 <212> Type: DNA <211> Length: 478       SequenceName: # 178       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caaccaggcc ttaggtgcta cagctaaagt catcaccgac cctgatatcc tgaaaacctg 60 tgtaccagac ctaagtgaca agagactgga agtggttggg ctggagggtg caattgagat 120 gggccaaatc tataccaagc tcaagaatgc tggacgtcgg ctggccaagt gctctgagat 180 caccttccac accacaaaaa cccttcccat gcaaattgac gtagaaccct ggatgcagac 240 gccctgtaca atcaagatca cccacaagaa ccagatgccc atgctcatgg gcccaccccc 300 ccgctccacc aatttctttg gcttcttgag ctaaggggga cacccttggc ctccaagcca 360 gccttgaacc cacctccctg tccctggact ctactcccga ggctctgtac attgctgcca 420 catactcctg ccagcttggg ggagtgttcc ttcaccctca cagtatttat tatcctgcac 480 cacct 485 <212> Type: DNA <211> Length: 485       SequenceName: # 179       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctttcagc tctatcagag tgaccctagt ggaaattacg ggggatggaa ggccacatgc 60 attggaaata atagcgctgc agctgtgtca atgttgaaac aagactataa agaaggagaa 120 atgaccttga agtcagcact tgctttagct atcaaagtac taaataagac catggatgtt 180 agtaaactct ctgctgaaaa agtggaaatt gcaacactaa caagagagaa tggaaagaca 240 gtaatcagag ttctcaaaca aaaagaagtg gagcagttga tcaaaaaaca tgaggaagaa 300 gaagccaaag ctgagcgtga gaagaaagaa aaagaacaga aagaaaagga taaatagaat 360 cagagatttt attactcatt tggggcacca tttcagtgta aaagcagtcc tactcttcca 420 cactaggaag gctttacttt ttttaactgg tgcagtggga aaataggaca ttacatactg 480 aattgggtcc ttgtcatttc tgtccaattg aatactttat tgtaacgatg atggttaccc 540 ttcatggacg tcttaatctt 560 <212> Type: DNA <211> Length: 560       SequenceName: # 180       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgggatctc ctggcagttt gacccttgct gcaagtacca agtggagtac gacgcctata 60 aactgtcgcg cctgcctctg cacacactca cctcctccac cccggtggtg ctggtccgga 120 aggacgacct gcacagaaag agactgcaca acacgatagc actggccgcc ctggtgtact 180 gtgtaaagaa gatttacgaa ctctatgccg tatgatttca gtagaacagg gagcgaagca 240 aaaccacccg gcccacaaga gacaacagag tattcagatc gccacactct gtgaggcagc 300 agagcctggg caggtgtttg gcttagtatt tgttattttt aaaaaataac agatcacggg 360 tgtacccagg gtttttcagc tcattacact aagatgtgga tttccataac ccaagagggg 420 ggtctgaggc tgtggaagtc cgactgggca gtggaatgct gatggaggca gacgctgccg 480 agggggtgtg gacgtgcttt gggggaggtc tttaagtcta ttgtttaact gtaccatcca 540 gagcccac 548 <212> Type: DNA <211> Length: 548       SequenceName: # 181       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttgctgcaga ctcatccttt ttaaatgaga cttgttttcc cctctctttg agtcaagtca 60 aatatgtaga tgcctttggc aattcttctt ctcaagcact gacactcatt accgtctgtg 120 attgccattt cttcccaagg ccagtctgaa cctgaggttg ctttatccta aaagttttaa 180 cctcaggttc caaattcagt aaattttgga aacagtacag ctatttctca tcaattctct 240 atcatgttga agtcaaattt ggattttcca ccaaattctg aatttgtaga catacttgta 300 cgctcacttg ccccagatgc ctcctctgtc ctcattcttc tctcccacac aagcagtctt 360 tttctacagc cagtaaggca gctctgtcgt ggtagcagat ggtcccactt attctagggt 420 cttactcttt gtat 434 <212> Type: DNA <211> Length: 434       SequenceName: # 182       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcagcaagct ccagtgctac gtgtccctgg cattttaggt gtcggttggg taggcagtca 60 tggatcaggt aatgcagttt gttgagccaa gtcggcagtt tgtaaaggac tccattcggc 120 tggttaaaag atgcactaaa cctgatagaa aagaattcca gaagattgcc atggcaacag 180 caataggatt tgctataatg ggattcattg gcttctttgt gaaattgatc catattccta 240 ttaat 245 <212> Type: DNA <211> Length: 245       SequenceName: # 183       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cactcttatg ctgtacccag tttctaaact ggagactgtg tgtgccctct gggctctgag 60 tacccctgct ttgggcttgg gcctaggctg cattgaaaag agctgaaggt tgtggccttt 120 gcgctcctgg cccagccttt gttccccact ggagcagaag gggagatgga cgacacggtn 180 ggggcatctg gcctggccag tgccctgatc ccagagagcc cgaggaggtg tctcaggctg 240 cctgagtcgt gacctgctag gccagagccc actccatctg gtagaaggga aagcccatat 300 gctaccacca gctgtgtcca aaaccgccag ctctgttctt cctcagccag cctcgcccat 360 ccccttgagg tctcagcccc tttcccttgt agctcctccc ctggaggggg aatggcagca 420 ggggttgggg aaacagcatc tccaagcagc ttagagttgg ccatatttac ctcagcctgg 480 gcgctggtcc tttcttccgg cccctcccct ccaaaatgtg cctattgcta gagctcctc 539 <212> Type: DNA <211> Length: 539       SequenceName: # 184       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtgcggta caatctggag cccacagctg tcggtcagaa cctcctgtga gacagatgga 60 accttcacaa gggcgccttt ggttctctga acatctcctt tctcttcttg cttcaattgc 120 ttacccactg cctgcccaga ctttctatcc agcctcactg agctgcccac tactggaagg 180 gaactgggcc tcggtggccg gggccgcgag ctgtgaccac agcaccctca agcatacggc 240 gctgttcctg ccactgtcct gaagatgtga atgggtggta cgatttcaac actggttaat 300 ttcacactcc atctccccgc tttgtaaata cccatcggga agagactttt tttccatggt 360 gaagagcaat aaactctgga tgtttgtgcg cgtgtg 396 <212> Type: DNA <211> Length: 396       SequenceName: # 185       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtaagatgtc tctagcactg ctcaaagggc aaattttaaa acttcagtct gggtgaaaga 60 tttgctagtt ttacagaaag atttgctatc ttaaactcaa gctggttttt ctgttctcat 120 gtaagtgact gggatgctgt cttatgaatt cttccaaggt catgtttgtg aaataaacat 180 tacatgagag ctttcctgtc atctacacta tatgttgtct ggagtgttga acaaatttat 240 tttagtttct aagttgtaat ctatcctcat atggtctata cgattttgaa tgtgtgccac 300 tacatactga gatgataatg ctgtacaatt ttaagtggta gcagtttctg tatgcagta 359 <212> Type: DNA <211> Length: 359       SequenceName: # 186       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atcgttggaa cctgaagaat ctgaagtttt ttttaccacc atctttttct actctgtatg 60 gaagtagatc tttatgggga aaagagaatt tggggtgttc tgcaagccag tcaaagtggc 120 acagcaaatc atataaatcg aattaaatgg acaacaccgt tagatgtgta tgtaaaaatt 180 ttctgtttca tatttttcct ttcactttcg gtttaaaaca tgctatatgt actgtatgtc 240 ctgtagccca gtgcggctcc acagcatgga atctgatgta tgatatgata gaatgtggca 300 ctaaatgcag tttcagattt tatttttttt aatcatatga actaaaattg tcaattgtga 360 ggtgtgcttt tctcatcatg ttggttatat tgcacaattg gttatattta tgacctgata 420 ttcaaagact ctggcattga tagccagtgt gttttcttat ttaactccgt ttactacatt 480 ctacatggtg tttacgtgat ccacacttga aatactaga 519 <212> Type: DNA <211> Length: 519       SequenceName: # 187       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggatccag atacagctca tcacgaacta attctctctg aggatcggag acaagtgact 60 cgtggataca cccaggagaa tcaggacaca tcttccagga gatttactgc cttcccctgt 120 gtcttgggtt gtgaaggctt cacctcagga agacgttact ttgaagtgga tgttggcgaa 180 ggaaccggat gggatttagg agtttgtatg gaaaatgtgc agaggggcac tggcatgaag 240 caagagcctc agtctggatt ctggaccctc aggctgtgca aaaagaaagg ctatgtagca 300 cttacttctc ccccaacttc ccttcatctg catgagcagc ccctgcttgt gggaattttt 360 ctggactatg aggccggagt tgtatccttt tataacggga atactggctg ccacatcttt 420 actttcccga aggcttcctt ctctgatact ctccggccct atttccaggt ttatcaatat 480 tctcctttgt ttctgcctcc cccaggtgac taaggaaaag agcagaagct ccttggttta 540 accagc 546 <212> Type: DNA <211> Length: 546       SequenceName: # 188       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aactagtccg tagttcgagg gtgcgccgtg tccttttgcg ttggtaccag cggcgacatg 60 acggggtaca ctccggatga gaaactgcgg ctgcagcagc tgcgagagct gagaaggcga 120 tggctgaagg accaggagct gagccctcgg gagccggtgc tgcccccaca gaagatgggg 180 cctatggaga aattctggaa taaatttttg gagaataaat ccccttggag gaaaatggtc 240 catggggtat acaaaaagag tatctttgtt ttcactcatg tacttgtacc tgtctggatt 300 attcattatt acatgaagta tcatgtttct gaaaaaccat atggcatagt tgaaaagaag 360 tccagaatat tccctggtga tacaattctg gagactggag aagtaattcc accaatgaaa 420 gaatttcctg atcaacatca ttaaagatta tgtaaaaagt taaaaggctt atgagcctaa 480 gtttgttcct atatt 495 <212> Type: DNA <211> Length: 495       SequenceName: # 189       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggagatggac cctggtatta ctatgagaca attgacaagg aacttattga tcattctccg 60 aaagcaactc ctgacaatta agcctttttt tctccaaata caaagtatat tctctttatt 120 ggaaaataaa ttaataaata tattctgtat ttttgctctc cgtgaaaaac aaaagagcct 180 ctgacattac tgtctctcag tgttggttca gattgaggct tttgtttgag gagtttggct 240 tccagtcccc aaagaaggtt taaaatgtac taataaaaac tggagaaata ggaatttgtg 300 aacccctaaa attgtagcaa ctttgaaagg ttagtgtttt atttacctga caaatggaag 360 ttatagaagt ctaataatgt taagcaccag taattatagt attttgtaca aatgcctgta 420 ctgtagatgt ctgta 435 <212> Type: DNA <211> Length: 435       SequenceName: # 190       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctcccccaac cttagatgtt ctaagtcttt ccattggatc tcattggacc cttccatggt 60 gtgatcgtct gactggtgtt atcaccgtgg gctccctgac tgggagttga tcgcctttcc 120 caggtgctac acccttttcc agctggatga gaatttgagt gctctgatcc ctctacagag 180 cttccctgac tcattctgaa ggagccccat tcctgggaaa tattccctag aaacttccaa 240 atcccctaag cagaccactg ataaaaccat gtagaaaatt tgttattttg naacctcgct 300 ggactctcag tctctgagca gtgaatgatt cagtgttaaa tgtgatgaat actgtatttt 360 gtattgtttc aattgcatct cccagata 388 <212> Type: DNA <211> Length: 388       SequenceName: # 191       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccgatcctc gcgtgagaca gatcaagatc aagaccggcg tggtgaagcg gttggtcaaa 60 gaaaaagtga tgtatgaaaa agaggcaaaa caacaagaag aaaagattga aaaaatgaga 120 gctgaagacg gtgaaaatta tgacattaaa aagcaggcag agatcctaca agaatccagg 180 atgatgatcc cagattgcca gcgcaggttg gaagccgcat atttggatct tcaacggata 240 ctagaaaatg aaaaagactt ggaagaagct gaggaatata aagaagcacg tttagtactg 300 gattcagtga agttagaagc ctgaaacttt tctcgtatgg ggtggttttt gcattaaatc 360 ctggggtcca ttttacaatc cattattttt gaccactgct atgtgttcaa gtagt 415 <212> Type: DNA <211> Length: 415       SequenceName: # 192       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggagaacctc gaggtgtcca gttccttcaa ctacagtgtg ctgcagcatc ttggccagtt 60 tccacccctt atgcctaaca agcagatcgc ggagtcggcc aatagcagta gcccccagag 120 ctctgcgggg ggcaagcccg ccatgtccta tgccagcgct ctgcgggccc ctccaaagcc 180 caggccccct cctgagcagg ccaagaagag tagcgaccct ctgtctctct tccaggaact 240 gagcctaggg agctcatctg gcagcaatgg cttttactca tattttaaat aatcactttt 300 ttttccctca agggagaatg ttttaatttc tgtttgtatc agtagaatta aggtagttgg 360 acttcatcta tagatgcaca gttccctttg ttttaatatt aaatatgttc tcacttaatt 420 gctttgctgc tagacttgca act 443 <212> Type: DNA <211> Length: 443       SequenceName: # 193       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggagcatgct gttttgtcaa tcaatataaa atatttatga ggtctccccc acccccagga 60 ggttatatga ttgctcttct ctttataata agagaaacaa attcttattg tgaatcttaa 120 catgcttttt agctgtggct atgatggatt ttattttttc ctaggtcaag ctgtgtaaaa 180 gtcatttatg ttatttaaat gatgtactgt actgctgttt acatggacgt tttgtgcggg 240 tgctttgaag tgccttgcat cagggattag gagcaattaa attatttttt cacgggactg 300 tgtaaagcat gtaactaggt attgctttgg tatataacta ttgtagcttt acaagagatt 360 gttttatttg aatggggaaa atacccttta aattatgacg gacatccact agagatgggt 420 ttgaggattt tccaagcgtg taataatgat gtttttccta acatgacaga tgagtagtaa 480 atgttgatat atcctataca tgacagtgtg 510 <212> Type: DNA <211> Length: 510       SequenceName: # 194       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caagtatcgg ggctctgcta tcaaggtgca aagtccttcg tggatgcaac ctcaaccata 60 tattctacag caccctggtg ccgtgttaac tccctcaatg gagcacacca tgtcactaca 120 gcccgcatca atgatcagcc ctctggccca gcagatgagt catctgtcac taggcagcac 180 cggaacatac atgcctgcaa cgtcagctat gcaaggagcc tacttgccac agtatgcaca 240 tatgcagacg acagcggttc ctgttgagga ggcaagtggt caacagcagg tggctgtcga 300 gacgtctaat gaccattctc catatacctt tcaacctaat aagtaactgt gagatgtaca 360 gaaaggtgtt cttacatgaa gaagggtgtg aaggctgaac aatcatggat ttttctgatc 420 aattgtgctt taggaaatta ttgacagttt tgcacaggtt cttgaaaacg ttatttataa 480 tgaaatcaac taaaactatt tttgctataa gttctataag gtgcataaaa cccttaaatt 540 catctagtag ctgttccccc 560 <212> Type: DNA <211> Length: 560       SequenceName: # 195       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctcccatcc aaatcctact aggaagagag tgggctgcag atgaatctgt gactcatgtt 60 tccctgtttc aaagggatcc tggggaagga ggggaacatg cttgcagtat ctctccctgt 120 ctgtctgctc acataagcat tccgtccatc taagctcatc gtgctactgg tatgtgtatg 180 tgcagttaca cagtttcctg tatcataaat cctagtgtgt ttatacaagg agacatctgt 240 ggtttcccca accgttccaa aaggctattt caaaggaacc agcccacgta tgagaaatga 300 atgtaacact gtggacattg acttcccgca taaggcaggg tgaccccctg aactccagat 360 gtttgcacag tatcttatgt gttgttttcc gttg 394 <212> Type: DNA <211> Length: 394       SequenceName: # 196       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttcctgaaca tgagtttgcg acgggaccag tgtgtcttga tgatgagaat gagtttcctc 60 ctataatctt gtgccgtgga aatcagaagg gcaaaacgaa gcagtcatga tgagaagcac 120 acctcagaaa tcaggacatc ccccc 145 <212> Type: DNA <211> Length: 145       SequenceName: # 197       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taaaaacagt tgccagtgat aatctgnatg anggnaaaaa gaaccctgca aatggctatt 60 gnagttggan gtnantgntn ttgatatgta agagatattc agaatgctca cactgaaaat 120 gcctcaactt tttaaagtgt aagaaaccac catgagtggt gtctagattt ctaatgaaga 180 atcatgatac agtttggatt aagtatcttg gactggtttt aaacagtgct ttgtaccgga 240 tctgctgaag catctgtcca gctggtatcc tgtgaaagtt tgttattttc tgagtagaca 300 ttcttataga gtattgtctt taaaatcaga ttgtctcttc tatattgaaa gcatttttat 360 gttttctaat ttaaaaatta atattttctt atagatattg tgcaataaag ctgaagtaga 420 atgtgtggtt tttgcaaatg ct 442 <212> Type: DNA <211> Length: 442       SequenceName: # 198       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agagacttgg tcaggtactt tcagggcctg ggccccccac cgaagttcca ggtaacactg 60 aatttctggg aagagagcca tggctccagc catactccac agaatcttat cacagtgaag 120 atggagcagg cctttgcccg atacttgctg gagcagactc cagagcagca ggcagccatt 180 ctgtccctgg tgtagagcct gggggaccca tcttccacct cacctctttg ttcttcctgt 240 ctcctttgaa gtagactcat tcttcacacg attgacctgt cctctttgtg ataattctca 300 gtagttgtcc gtgataatcg tgtcctgaaa atcctcgcac acactggctg gtggagaact 360 caaggctaat tttttatcct tttttttttt ttatttttga gatatacgcc ctctttcatc 420 tgtaagggac taggaaattc caaatggtgt gaacccaggg ggcctttccc tcttccctga 480 cctcccaact ctaaagccaa gcactt 506 <212> Type: DNA <211> Length: 506       SequenceName: # 199       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgaagctct ggaggcaggg ctccgtcacc accttcctgg ccaagatgca catcttcttc 60 accacctttg ccctgtgagg tgccagcacg ggccacctgc gggtgtggcg cagccagggc 120 tcacactgcg tgggagggac tgggtcacta ttgtggtttt tactataact ttgtaaatta 180 acttaatttt gctgacttga ctcctgtggc ttctggaccc ctcctctgcc ccgcaggagg 240 aagttccacg gcaggtggtg cgttcccatg taggcaccaa gtggaagctt gcacggtggg 300 ccacggccgt ggcgggtgcc ctgtgggtga ggctgggtga tgacctgagg accagagaca 360 cgcgaccatg ttggggctct tggactcctc tggatgaccc gtccccaaac gttgacattc 420 catttcatgt tccactgtga ttaa 444 <212> Type: DNA <211> Length: 444       SequenceName: # 200       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaagccaca gcatcctaca aggaagaaat cgtgcatcag ctgcccagta ataaaccaga 60 agagctagaa aataatgtag atcagatctt gaaatggatt gagcagtgga tcaaagatca 120 taactcttga cttataaggc tagctactta ataatcactc ttgttgatat ctctgccgac 180 atcatagaaa ttggtcaagt gtcagtaaca ctttattaaa atcatgttgc agaaccagca 240 ggtggatagt atataggttt atgcctgggg ttcttt 276 <212> Type: DNA <211> Length: 276       SequenceName: # 201       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcagggatt ggggtcacac ccttcgcatc cattctcaag tcagtctggt acaaatattg 60 caataacgcc accaatctga agctcaaaaa gatctacttc tactggctgt gccgggacac 120 acatgccttt gagtggtttg cagatctgct gcaactgctg gagagccaga tgcaggaaag 180 gaacaatgcc ggcttcctca gctacaacat ctacctcact ggctgggatg agtctcaggc 240 caatcacttt gctgtgcacc atgatgagga gaaagatgtg atcacaggcc tgaaacaaaa 300 gactttgtat ggacggccca actgggataa tgaattcaag acaattgcaa gtcaacaccc 360 taataccaga a 371 <212> Type: DNA <211> Length: 371       SequenceName: # 202       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaagatgct gctgttcagc gggcggcgcc tctggaggtt cgacgtgaag gcgcagatgg 60 tggatccccg gagcgccagc gaggtggacc ggatgttccc cggggtgcct ttggacacgc 120 acgacgtctt ccagtaccga gagaaagcct atttctgcca ggaccgcttc tactggcgcg 180 tgagttcccg gagtgagttg aaccaggtgg accaagtggg ctacgtgacc tatgacatcc 240 tgcagtgccc tgaggactag ggctcccgtc ctgctttgca gtgccatgta aatccccact 300 gggaccaacc ctggggaagg agccagtttg ccggatacaa a 341 <212> Type: DNA <211> Length: 341       SequenceName: # 203       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctggaatgt tttctggctc agctgcagca acatctgtga gcccagtgtc tgccctgtgt 60 ccctgggctc gctccaagtg caggaacata catgcagggc ccaacatgat gatggtgtga 120 agggcaggaa acagtcctct gaaggagtgg ggaggtgggc agtctgcccc cgccaggtac 180 catcgcctcc tgccagcttc cttagaccag gcagggctgc catggtgcta gctgcaagtc 240 catcagtatt gaccgtctcg ctccatcttg gtcctccgga gtcccaagtt tccttttcat 300 caaatctgac aagagagaag aaacatgggt gtgcttggcc cacagggcct ggtggtgatg 360 gacctccccg ctccctcaag ctctggatgg ctgcagtgtt gt 402 <212> Type: DNA <211> Length: 402       SequenceName: # 204       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgatctctgt ctgagctctg aagggtccga agtgatttta gctacatcaa gtgatgaaaa 60 acacccacct gaaaatatca ttgatgggaa tccagaaacg ttttggacca ccacaggaat 120 gtttccccag gaattcatta tttgtttcca caaacatgta aggattgaaa ggcttgtaat 180 ccaaagttac tttgtacaga ccttgaagat tgaaaaaaca cgtctaaaga gccagttgat 240 tttgagcaat ggattgaaaa agatttggta cacacagagg ggcagcttca aa 292 <212> Type: DNA <211> Length: 292       SequenceName: # 205       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaaggcagct tcccgagctg atgctaaaga agacagactt tcccttcctc ccagcagcag 60 cagtgcagag cccgcctgga gggatgtggg ggctgtgcag ggtgcagcgc tcaggtggat 120 cctgggaagc agcctctgga tgctgagtgg agggagccac tgagcacagc aaggcaccaa 180 agcccctgga gaaaccgcca gggcgaggtg cgaccatcat caggatcaaa gcagacgggg 240 cgtgggtggg gaaggggctc tgggaccaga ccccccacac tactgcgtct ttgtttctat 300 cagtctttgt agaagcaggt ggtggtggaa attccagcag gtgggtcccg cagaggccct 360 gaggcctcac ttttcggatc ttctgtccca gatcctgctc cctccctgct gagcctgggg 420 ttcccctggc attggcccca gccttctgaa agccggcgct gcagccagag gccgcacgct 480 gcactgtcgc gacgcagaga ggcttctgtg caggctggga tcgggcccca tgtctgtgct 540 gtctagtttg tgttca 556 <212> Type: DNA <211> Length: 556       SequenceName: # 206       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaggtgtgg ttttcatttc tcagtcacca acagatgaat aattatgctt aataataaag 60 tatttattaa gactttcttc agagtatgaa agtacaaaaa gtctagttac agtggattta 120 gaatatattt atgttgatgt caaacagctg agcaccgtag catgcagatg tcaaggcagt 180 taggaagtaa atggtgtctt gtagatatgt gcaaggtagc atgatgagca acttgagttt 240 gttgccactg agaagcaggc gggttgggtg ggaggaggaa gaaagggaag aattaggttt 300 gaattgcttt ttaaaaaaaa aagaaaagaa aaagacagca tctcactatg ttgccaaggc 360 tcatcttgag aagcaggcgg gttgggtggg 390 <212> Type: DNA <211> Length: 390       SequenceName: # 207       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctcccagc aagggtagga cgggccgcat gcgggcagaa agttgggact gagcagctgg 60 gagcaggcga ccgagctcct tccccatcat ttctccttgg ccaacgacga ggccagccag 120 aatggcaata aggactccga atacataata aaagcaaaca gaacactcca acttagagca 180 ataacggctg ccgcagcagc cagggaagac cttggtttgg tttatgtgtc agtttcactt 240 ttccgataga aatttcttac ctcatttttt taagcagtaa ggcttgaagt gatgaaaccc 300 acagatccta gcaaatgtgc ccaaccagct ttactaaagg gggaggaagg gagggcaaag 360 ggatgagaag acaagtttcc cagaagtgcc tggttctg 398 <212> Type: DNA <211> Length: 398       SequenceName: # 208       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cacctagagt ctgttgtcat ttcactaata ggataagaca aattttttgc tttgaaaaaa 60 tttttctgca tgcccaggtg tctgtctctg gctgaggttt tgtctatttt acagtgtttc 120 aatccagcca taaaaattaa cttgtgattt tttttttccc aaagtcatgc ttttccttaa 180 ttatattttt attttattat tttagtgtct tgagaaaaat accaagagat ataatgtttc 240 ttttaattgt ctatgcttaa tcatctttaa acacttttta aatttctaac cacaagacct 300 ctctataatg gtaaatgtaa gacatcacca ttttatcact caaagtatgt tattgaaagt 360 ttctatttgg ttgataaaag gaacaatttt ttcccacttt tgatgcctgt gatgcaattt 420 tttattgcct acaatgagat acacttagta caaaaaatga aaatctggta tttcaaaatt 480 gcatttcttg tataataggt cagatttatt aactactcat actttttctt tacactaatc 540 g 541 <212> Type: DNA <211> Length: 541       SequenceName: # 209       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcccaccttt caacttcttg gatcacaact ctggccttcc taagccatac ccaagtacac 60 atatagcaca tttcacccaa ggaccttccc tctttggaca ctatgttaca tacccctctt 120 ggcctttgaa cctgtgccag gaagtgtgag ctgttacagc aaggggctag aagtgaaaaa 180 agtaattctg gagacaagca ctattttctc ttcctacccc acctccattt ctaatgccta 240 ctgccatcaa ggccttgttt tgcttttctt tttggattgt tcagagaaat gtgtgtggca 300 tgtgtaagaa aagtgtatat actatcttat actacctctc caggttgcca gagagttgcg 360 aggagagcaa ggggcacaac cgtctccctt tatagttcta cttttct 407 <212> Type: DNA <211> Length: 407       SequenceName: # 210       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atcgtttctc tctctgaaag caccagtgcc cagagtctgc tcggtaataa aattatggat 60 ccagattgtt ctgagagacg aagatacttg ctgctgatag aggtgaaaac gagattgatc 120 cgtctggggt tttacggtgt gcactgggtg ctgcacagac ttgtcaaggt ttgctacgtc 180 ctctgggcat ctgcaaaagg ccctgctctc tggagtgttg tatatagtgt agcaaaagag 240 tatttataca tcccaccaat caaaacacag ctttattacc tcatgcgaac tcatacaaac 300 caatagaatt tcaacatgtt ctgtagctta gagtgctcac ttactacctc tgaacaatac 360 tcacgctgta gtttgtctct 380 <212> Type: DNA <211> Length: 380       SequenceName: # 211       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcgaggacga ggcttaaaaa cttctcagat caatcgtgca tccttagtga acttctgttg 60 tcctcaagca tggtctttct acttgtaaac tatggtgctc agttttgcct ctgttagaaa 120 ttcacactgt tgatgtaatg atgtggaact cctctaaaaa ttacagt 167 <212> Type: DNA <211> Length: 167       SequenceName: # 212       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atctgattcc agaattgccc tgaagtctgg ctatggaaaa tatcttggta taaattcaga 60 tggacttgtt gttgggcgtt cagatgcaat tggaccaaga gaacaatggg aaccagtctt 120 tcaaaatggg aaaatggctt tgttggcctc aaatagctgc tttattagat gcaatgaagc 180 aggggacata gaagcaaaaa gtaaaacagc aggagaagaa gaaatgatca agattagatc 240 ctgtgctgaa agagaaacca agaaaaaaga tgacattcca gaagaagaca aaggaaatgt 300 aaaacaatgt gaaatcaatt atgtaaagaa atttcagagc ttccaagacc acaaacttaa 360 aataagtaaa gaagacagta aaattcttaa aaaggctcgg aaagatggat ttttgcatga 420 gacgcttctg gacaggagag ccaaattgaa agccg 455 <212> Type: DNA <211> Length: 455       SequenceName: # 213       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttttatggc atatgtctcc gatttagatg gttattctct agaaaatagt atttaaagac 60 attttatgaa atcttcattg tcaaaacctt taataaaagt ggaaatattt tgaaatgccc 120 tttttcttga taccactcat ccacgtgttc ctgattgtcc acatttcatg ataaaatgag 180 agctctgcag agaatgttag cctttctgtt gtaaatgtaa tcttcaagta gtcacttttt 240 gttaagttct ttagaaagta gttgtcaagt acttagtcat ccctattatg atatgagata 300 gtacagcttt tcaggaagct tagatctgaa tttactttga aaaacaattg taatgaatat 360 tttatattta cattgagaat ttcaactagc ttctgatcaa tttttaataa aaaattttca 420 aatcatgtta gctgttaa 438 <212> Type: DNA <211> Length: 438       SequenceName: # 214       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacgcatctg tgaatggctg gagctccgat gaggaaaagg cagggggcct ggatgatgaa 60 gaggaggccg agctcgtccc ctccgaggtg ctcatgcacc aggccatcca caccatcgag 120 ttctgcctgg gctgcgtctc caacaccgcc tcctacctgc gcctgtgggc cctgagcctg 180 gcccacgccc agctgtccga ggttctgtgg gccatggtga tgcgcatagg cctgggcctg 240 ggccgggagg tgggcgtggc ggctgtggtg ctggtcccca tctttgccgc ctttgccgtg 300 atgaccgtgg ctatcctgct ggtgatggag ggactctcag ccttcctgca cgccctgcgg 360 ctgcactggg tggaattcca gaacaagttc tactcaggca cgggctacaa gctgagtccc 420 ttcaccttcg ctgccacaga tgactagggc ccactgcagg tcctgccaga cctccttcct 480 gacctctgag gcaggagagg aataaagacg gtccgccctg g 521 <212> Type: DNA <211> Length: 521       SequenceName: # 215       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaagatggc cgggaactcg atcctgctgg ctgctgtctc tattctctcg gcctgtcagc 60 aaagttattt tgctttgcaa gttggaaagg caagattaaa atacaaagtt acgcccccag 120 cagtcactgg gtcaccagag tttgagagag tatttcgggc acaacaaaac tgtgtggagt 180 tttatcctat attcataatt acattgtgga tggctgggtg gtatttcaac caagtttttg 240 ctacttgtct gggtctggtg tacatatatg gccgtcacct atacttctgg ggatattcag 300 aagctgctaa aaaacggatc accggtttcc gactgagtct ggggattttg gccttgttga 360 ccctcctagg tgccctggga attgcaaaca gctttctgga tgaatatctg gacctcaata 420 ttgccaagaa actgaggcgg caattctaac tttttctctt ccctttaatg cttgcagaag 480 ctgttcccac catgaaggta a 501 <212> Type: DNA <211> Length: 501       SequenceName: # 216       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgctctcgtt tcattttctg cagcgcgcca cgaggatggc ccacaagcag atctactact 60 cggacaagta cttcgacgaa cactacgagt accggcatgt tatgttaccc agagaacttt 120 ccaaacaagt acctaaaact catctgatgt ctgaagagga gtggaggaga cttggtgtcc 180 aacagagtct aggctgggtt cattacatga ttcatgagcc agaaccacat attcttctct 240 ttagacgacc tcttccaaaa gatcaacaaa aatgaagttt atctggggat cgtcaaatct 300 ttttcaaatt taatgtatat gtgtatataa ggtagtattc agtgaatact tgagaaatgt 360 acaaatcttt catccatacc tgtgcatgag ctgtattctt cacagcaaca gagctcagtt 420 aaatgcaact gcaagtaggt tactgtaaga tgtttaagat aaaagttctt ccagtcagtt 480 tttctcttaa gtgcct 496 <212> Type: DNA <211> Length: 496       SequenceName: # 217       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atatcatatt ttctatcatc atgttgtgta tatgtgcaaa cctgtacttc catgatgtgg 60 gaaggtgagg ctgccaagga gaagtactta ccaggactct tcaaaatgat acattaggac 120 agtgagtaat ttttggataa ggtatgctga agaatctcct gcagaagtct gatacatgat 180 tttcatgtta attgtaaatg ttaattccct cttgcaaggg agacatatcc tagatcactt 240 tgctttttct ttaaggagct gatgttgcac ctaaacattc caacccttaa agctaaaaca 300 gcacaaaaaa atttcacttt tgaaatgaaa tttttataat tgtatggcaa aaggctatgt 360 aaaaacaaat cttgcatctt aagacaaata ttcttttatt tctgttaaac tgaatataca 420 attgttccct aggcaaccaa cttttgctta 450 <212> Type: DNA <211> Length: 450       SequenceName: # 218       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgcttctga gtgacggacc agctcacaca atgtcttgtt tcagtccatg atcccactga 60 cctactcttg cctgctggag ggtaatgaga agctttggtt ctgccatctc tcccactctg 120 ccaggtgctg gctgtggagc aaaggctcac ctttgtggag aggataaaac ctncccaacc 180 tacctcacca tggtttttca cattgcaaag ggtaataaca tgggcagtgc ggacttaggc 240 taccccctcc agtttgcttt ccgtaaatgc aaattgtcct tactgcaagt caggaatgat 300 tgctgactca cagtagggct gctatgcctg tgtgtaaact tggggatggc tgagggaaca 360 tagactcact cttccacatt cccaagttgg tctagtgtgc tgcccagtag caaaccatgg 420 cagactcacc acctattctg agttccaggg ctgctgtagg gcagggtggg cttcctccca 480 gacttgcctt accctgggct gatctttgcc cctggtatgc attaat 526 <212> Type: DNA <211> Length: 526       SequenceName: # 219       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggtctgaat ctagcaccat gacggaacta gagacagcca tgggcatgat catagacgtc 60 ttttcccgat attcgggcag cgagggcagc acgcagaccc tgaccaaggg ggagctcaag 120 gtgctgatgg agaaggagct accaggcttc ctgcagagtg gaaaagacaa ggatgccgtg 180 gataaattgc tcaaggacct ggacgccaat ggagatgccc aggtggactt cagtgagttc 240 atcgtgttcg tggctgcaat cacgtctgcc tgtcacaagt actttgagaa ggcaggactc 300 aaatgatgcc ctggagatgt cacagattcc tgcagagcca tggtcccagg cttcccaaaa 360 gtgtttgttg gcaattattc ccctaggctg agcctgctca tgtacc 406 <212> Type: DNA <211> Length: 406       SequenceName: # 220       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagaagagg acagtgctcc agtgaaagtg gaagaacaaa ggaagatgag tcaggatagt 60 gtccatcaca cctcagggga taagagcact gattatgcta atttttacca gggattgtgg 120 gattgtactg gagctttttc tgatgagttg tcatttaagc gtggtgatgt gatttacatt 180 cttagcaagg aatacaatag atatggctgg tgggtaggag aaatgaaggg agccattggc 240 ttggtgccta aagcctacat aatggagatg tatgatattt gagagtcctg gaaaaggaaa 300 attcttctgc ttgtctgcaa atgctttgga tttagaagcg tcatgaaagc acgagtgaca 360 gctcctaacc tctccttgtt ttattaaaca ttacttatct ttgactgtta ttttatgcag 420 tcgctcatta a 431 <212> Type: DNA <211> Length: 431       SequenceName: # 221       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tacgtgtatc atgcgagttt tttttggtag atgctgaaga atgtggttgc taaacaaaga 60 atgctaaaga atgttcaaac tttatagata actttattgt tattatttat tttcacacat 120 ttaattccta ttaagtacag ccgcaagaaa gaaaaaatga tgaagttgca aatggcagtg 180 tgctgtcacc tgcaacagaa gtgcgtacca gaagtatgac tcatgcaaag cattttaccg 240 tacaaatatc ctggtgcgat gatgggcctg gcaacatttt ctactgtact tttgtttaaa 300 tttaatgaaa caaaaaattc ctaagaaata ccaccctacc actaacaaaa tggtataaag 360 aatctcccag ccaggccaac atggtgaaac cctgtctcta ctaanaatta gccaagtgtg 420 gtaatgttca cctgcagtcc c 441 <212> Type: DNA <211> Length: 441       SequenceName: # 222       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttttgcaggg aaagttctgt ttcttctttg atacctttgt tctgtcccct gccccatccc 60 cagcactcat gatcttgaag cccctatcac actctagttc agtcctgtga accatgtcct 120 gagggccttg cagggaagta ggaaatagaa actcctccac aaagagccga ggatcagaga 180 agacccctga gatgaatcag ggccctgccc tgcccaccaa ctcttttcta gcaatcatgt 240 cctgcccagg ctgcaggctt cattaggctc ctgctgtcct ccatgatgtg actagcacaa 300 ggtgtatata tgttttgtac ctctgccgat ggctgtacat 340 <212> Type: DNA <211> Length: 340       SequenceName: # 223       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccaagccctc cagcaaggat tcaggagtgc ccctcgggcc tcgccatgag gctcttcctg 60 tcgctcccgg tcctggtggt ggttctgtcg atcgtcttgg aaggcccagc cccagcccag 120 gggaccccag acgtctccag tgccttggat aagctgaagg agtttggaaa cacactggag 180 gacaaggctc gggaactcat cagccgcatc aaacagagtg aactttctgc caagatgcgg 240 gagtggtttt cagagacatt tcagaaagtg aaggagaaac tcaagattga ctcatgagga 300 cctgaagggt gacatccagg aggggcctct gaaatttccc a 341 <212> Type: DNA <211> Length: 341       SequenceName: # 224       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gactatgacc caaagaagga tcaaaaccca gcagagtgca agcagcagtg aagcaggatg 60 tatgtggcct tgaggataac ctgcactggt ctaccttctg cttccctgga aaggatgaat 120 ttacatcatt tgacaagcct attttcaagt tatttgttgt ttgtttgctt gtttttgttt 180 ttgcagctaa aataaaaatt tcaaatacaa ttttagttct tacaagataa tgtcttaatt 240 ttgtaccaat tcaggtagaa gtagaggcct accttgaatt aagg 284 <212> Type: DNA <211> Length: 284       SequenceName: # 225       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taacctgtcc gtggagaacg ctgcagaaat tctcatcctg gccgacctcc acagtgcaga 60 tcagttgaaa actcaggcag tggatttcat caactatcat gcttcggatg tcttggagac 120 ctctgggtgg aagtcaatgg tggtgtcaca tccccacttg gtggctgagg cataccgctc 180 tctggcttca gcacagtgcc cttttctggg acccccacgc aaacgcctga agcaatccta 240 agatcctgct tgttgtaaga ctccgtttaa tttccagaag cagcagccac tgttgctgcc 300 actgaccacc aggtagacag cgcaatctgt ggagctttta ctctgttgtg aggggaagag 360 actgcattgt ggccccagac ttttaaaaca gcactaaata acttggggga aacgggggga 420 gggaaaatga aatgaaaacc ctgttgctgc gtca 454 <212> Type: DNA <211> Length: 454       SequenceName: # 226       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcataaggaa gcccacttta tctaaatgat attagccagg atccttggtg tcctaggaga 60 aacagacaag caaaacaaag tgaaaaccga atggattaac ttttgcaaac caagggagat 120 ttcttagcaa atgagtctaa caaatatgac atccgtcttt cccacttttg ttgatgttta 180 tttcagaatc ttgtgtgatt catttcaagc aacaacatgt tgtattttgt tgtgttaaaa 240 gtacttttct tgatttttga atgtatttgt ttcaggaaga agtcatttta tggatttttc 300 taacccgtgt taacttttct agaatccacc ctcttgtgcc cttaagcatt actttaactg 360 gtagggaacg ccagaacttt taagtccagc tattcattag atagtaattg aagatatgta 420 taaatattac aaagaataaa aatatattac tgtctcttta gtatggtttt cagtgcaatt 480 aaaccgagag atgtcttgtt tttttaaaaa gaatagtatt taataggttt ctgacttttg 540 tggatcattt tgcacatagc tttatcaact 570 <212> Type: DNA <211> Length: 570       SequenceName: # 227       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caggacttct ttctgcggaa atgtgtgtgt atacttatgt gtgtgtatgt gtgagtgtga 60 atatatgtat atgtgtacat atggacatac acatttacat atatataaag tatatatata 120 catatatata tatatatgta tgaaacccgc atggaattat ctgtatgaaa tcaaggtgcg 180 ctgtggaaac aataattcac ccagtttagt gggtggtagg gtacgtggcc agacacagtc 240 acccagtttt tgttcatacc agggtcatgc gttgagctac tgacaaactc aggcggaggt 300 gaccatgccc ttcaccaaag ctgcctccca gtggccacac agaactctcc ctgctggact 360 cacctgagga aagaggctcc agcatggggt gggtcagaga tgtgcttgca aggtccaggg 420 actgcgtggt ctgccagctg agatgctcct cgggctggcc caggtgctga ccttgccaca 480 ggcagatgaa tgtcttgaaa gctcccgggc ctcagcctcc catctcctct ccttcccagg 540 aatccttgat ctcatgacta tt 562 <212> Type: DNA <211> Length: 562       SequenceName: # 228       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attggcctgt ggcgagggag cggctgacat tattatcgga cacttatgta tcagacatga 60 aatgactcca gtaaaccctg gtgttggcca gtgctgcact tcttcatatg ccaacaggag 120 gccatgcttc agcagcttgg tggtggatga aacatatgtc cctcctgcat tctctgatga 180 caagttcatt ttccataagg atctgtgcca agctcagggt gtagcgctgc aaacgatgaa 240 gcaagagttt ctcattaacc ttgtgaagca aaagccacaa ataacagagg aacaacttga 300 ggctgtcatt gcagatttct caggcctgtt ggagaaatgc tgccaaggcc aggaacagga 360 agtctgcttt gctgaagagg gacaaaaact gatttcaaaa actcgtgctg ctttgggagt 420 ttaaattact tcaggggaag agaagacaaa acgagtcttt cattcggtgt gaacttttct 480 cttta 485 <212> Type: DNA <211> Length: 485       SequenceName: # 229       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caagttcatc cggcctgagg gagagatcac cgattacaga acccgggtca gcggggtcac 60 ccctcagcac atggtggggg ccacaccatt tgccgtggcc aggctagaga tcctgcagct 120 cctgaaaggc aagctggtgg tgggtcatga cctgaagcac gacttccagg cactgaaaga 180 ggacatgagc ggctacacaa tctacgacac gtccactgac aggctgttgt ggcgtgaggc 240 caagctggac cactgcaggc gtgtctccct gcgggtgctg agtgagcgcc tcctgcacaa 300 gagcatccag aacagcctgc ttggacacag ctcggtggaa gatgcgaggg caacgatgga 360 gctctatcaa atctcccaga gaatccgagc ccgccgaggg ctgccccgcc tggctgtgtc 420 agactgaagc cccatccagc ccgttccgca gggactagag gctttcggct ttttgggaca 480 <212> Type: DNA <211> Length: 480       SequenceName: # 230       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggctggtgc cctatttcca gccaccccag cagctaggga ggcaaagcag gctgcagtca 60 gtccctcaag ccagcgttgc atgtttggga tggtggctcc tgttgtcttg cgctctggga 120 agtcagatgt catttcaggc ctgcagtctc atcctgccct tgccatcctc ccatcgatgt 180 gccacgtggg tgtcacgtgt cccagatgca gtattcggca gccagccggg gagggctacc 240 tcctcctcct caccaccttg gggcttctca tgggaaatgt gcccccgccc caggaccctc 300 tcccttgtgg acaggcaggg agatgcatgc gagtgcatgc agcaggggat ggggccgtgt 360 ccgtgtgccc caccctccct cggctttact cctgcccagt gactgtgacc actgtccgtg 420 ttgccttctt gaacagcgat tccccccaac cccttcacca aaggtcttgg tacaaccagc 480 tgcccatttt gtgaaatt 498 <212> Type: DNA <211> Length: 498       SequenceName: # 231       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatggggcta ggagggagct gcaggaggag agcggtctga cagtggacgc cctgcacaag 60 gtgggccaga tcgtgtttga gttcgtgggc gagcctgagc tcatggacgt gcatgtcttc 120 tgcacagaca gcatccaggg gacccccgtg gagagcgacg aaatgcgccc atgctggttc 180 cagctggatc agatcccctt caaggacatg tggcccgacg acagctactg gtttccactc 240 ctgcttcaga agaagaaatt ccacgggtac ttcaagttcc agggtcagga caccatcctg 300 gactacacac tccgcgaggt ggacacggtc tagcgggagc ccagggcagc ccctgggcag 360 gagacgtggc tgctgaacag ctgcaaacca tcttcacctg ggggcattga gtggcgcaga 420 gccgggtttc at 432 <212> Type: DNA <211> Length: 432       SequenceName: # 232       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggacactaag tccattgtta catgaaagtg atagatagca acaagttttg gagaagagag 60 agggagataa aagggggaga caaaagatgt acagaaatga tttcctggct ggccaactgg 120 tggccagtgg gaggtgatgg tggacctaga ctgtgctttt ctgtcttgtt cagccttgac 180 ccaccttgag agagagccac caggaaggcg catcttagca gatgggagga actgctgaga 240 gaagatgggc agaaagctgg agcccctgga gttggctgtg tctgtgtttg tgactgatta 300 ctggctgtgt cttgggtggg cagaaactcg aacttgctat gtaatttgtg tctagttatt 360 cagaggagta agatggtgat gttcacctgg caatcagctg agttgagact ttggaataag 420 acactggttt tcatgcgctg ttttt 445 <212> Type: DNA <211> Length: 445       SequenceName: # 233       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaagtcttc ataaagccgc agtagaactt gagctgaaaa cccagatggt gttaactggc 60 cgccccactt tccggcataa ctttttagaa aacagaaatg cccttgatgg tggaaaaaag 120 aaaacaacca cccccccact gcccaaaaaa aaaagccctg ccctgttgct cgtgggtgct 180 gtgtttactc tcccgtgtgc cttcgcgtcc gggttgggag cttgctgtgt ctaacctcca 240 actgctgtgc tgtctgctag ggtcacctcc tgtttgtgaa aggggacctt cttgttcggg 300 ggtgggaagt ggcgaccgtg acctgagaag gaaagaaaga tcctctgctg acccctggag 360 cagctctcga gaactacctg ttggtattgt ccacaagctc tcccgagcgc cccatcttgt 420 gccatgtttt aagtcttcat ggatgttctg catgtcatgg ggactaaaac tcacccaaca 480 gatctttcca gaggtccatg gtgg 504 <212> Type: DNA <211> Length: 504       SequenceName: # 234       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagccatagt cgtgcctgtt tgcttagcat tcctattgac aactcttctg ggagtgctgt 60 tctgctttaa taagcgagac ctaattaaaa aacacatctg gcctaatgtt ccagatcctt 120 caaagagtca tattgcccag tggtcacctc acactcctcc aaggcacaat tttaattcaa 180 aagatcaaat gtattcagat ggcaatttca ctgatgtaag tgttgtggaa atagaagcaa 240 atgacaaaaa gccttttcca gaagatctga aatcattgga cctgt 285 <212> Type: DNA <211> Length: 285       SequenceName: # 235       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacacttcga gcactgtcca gtattctacc gtggtacaca gtggctacag acaccaagtt 60 ccgtcagtcc aagtcttctc aagatccgag tctacccagc ccttgttaga ttcagaggag 120 cggccagaag atctacaatt agtagatcat gtagatggcg gtgatggtat tttgcccagg 180 caacagtact tcaaacagaa ctgcagtcag catgaatcca gtccagatat ttcacatttt 240 gaaaggtcaa agcaagtttc atcagtcaat gaggaagatt ttgttagact taaacagcag 300 atttcagatc atatttcaca atcctgtgga tctgggcaaa tgaaaatgtt tcaggaagtt 360 tctgcagcag atgcttttgg tccaggtact gagggacaag tagaaagatt tgaaacagtt 420 ggcatggagg ctgcgactga tgaaggcatg cctaaaagtt acttaccaca gactgtacgg 480 caaggcggct acatgcctca gtgaaggact agtagttcct gctacaactt cagc 534 <212> Type: DNA <211> Length: 534       SequenceName: # 236       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caatgtccac tcaagttgca atgcaaaact ctggctcata ttcaatttct cagtttcaat 60 ccagaatgat caggtggacc aaactacgaa ttaacatgct tcctgctaca ataatttgtg 120 agccaatttc agaatgcttt gttgccagtt taattattgg atgggcagcc caccatgtgt 180 tcagatggga tattatggta tttttcatgt gtcattgcct ggcatggttt atatttgact 240 acattcaact caggggtgtc cagggtggca cactgtgttt ttcaaaactt gattatgcag 300 tcgcctggtt catccgcgaa tccatgacaa tatacatttt tttgtctgca ttatgggacc 360 caactataag ctggagaact ggtcgctaca gattacgctg 400 <212> Type: DNA <211> Length: 400       SequenceName: # 237       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttccagaac atgaacgggt ccgaatactt cgtgaagatc cagtccttcc tgggtggggc 60 ccccacggag gatttgaagg cgctcagtca gcagaatgtg agcatggact tggccacgtt 120 catgaagctg cggacggatg cggtgctgcc gttgactgtg gctgaggt 168 <212> Type: DNA <211> Length: 168       SequenceName: # 238       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggttagaata cagggtcact caagtagatg ggcactccag taaaaatgac atccacacac 60 tgttgaagga tcttaattca tatcttgaag ataaagtcta ccttacaggg tataacttta 120 cattagcaga tatactattg tactatggac ttcatcgctt tatagttgac ctgacagttc 180 aagaaaagga gaaatatctt aatgtgtctc gctggttttg tcacattcag cattatccag 240 gcatcaggca acatctgtct agtgttgtct tcatcaagaa cagactatat actaattccc 300 actagaagct gtccatgcca taca 324 <212> Type: DNA <211> Length: 324       SequenceName: # 239       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attcaggaca agctgcaact tcccccagct taacacaatg cccatacctc atacgatatg 60 cgccctcccg ttccatccct ggccccctca aacgagactt ctcacaaggc tgattacaga 120 tggtcaaacc tggcttccaa ggacagaatt gcctctcgga agccagctgt ggatctgagt 180 ccagagttgg ccacttgtgt gggtcctcac aagcaaagag agcactaaac ttgacattgg 240 gggtccacca ctccaacttt gctttctgaa ggttttggtg tacattgagc cccagaagga 300 aaggagagta tctgtgagtg ggggcctccc ttgaccccag tacgaagtct atgccctgaa 360 tccccagagt agcccttcct ggtgcccaac tggcctgggg acaaacagcg tccactacat 420 ctaggactgc cggctaagtg gacacacttc ttgacctcct accaggaact ttggt 475 <212> Type: DNA <211> Length: 475       SequenceName: # 240       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgcctggcct catttgagta tttttataat gtctctttta aagtctttgt cagataattc 60 cactgtacat gttattcagt gtttggtgtc cactgagttg tcatttgcca gacaagtgga 120 gatttttgca gctcatcctt gtattctcag tagttccgat atgtaccctc gacatgtgaa 180 tgttatctta tgagactctg ttttatttgt atccaacaga agatgtttat tatttatttg 240 gctttctgtg aactgaggtc ttaatatcag ctcattttaa aagtctttgc agtggtattc 300 ggatctatcc tgtgtgtgcc tatgagattg ggtgcagtgt atcctgttag ctccattctc 360 agggcgtttg aatgtgaatt aggaccagcg caatgaatgc tcaagt 406 <212> Type: DNA <211> Length: 406       SequenceName: # 241       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attaggagca acttgccctg tacccctgtg ctggtggtgg ccacccagac tgaccagcgg 60 gagatggggc cccacagggc ctcctgcgtc aatgccatgg aagggaagaa actggcccag 120 gatgtcagag ccaagggcta cctggagtgc tcagccctta gcaatcgggg agtacagcag 180 gtgtttgagt gcgccgtccg aactgccgtc aaccaggcca ggagacgaaa cagaaggagg 240 ctcttctcca tcaatgagtg caagatcttc taaaccccaa gagacttcac acaacactta 300 tgtatgcacc ccaaagacta atggggagag ggagggccgg gaagccagga aagcttggtg 360 ttttctctgg gtacacccca agcagcgtct ccgttttgga tacagttatt gatgaggctt 420 ggccactgga tgttttcact aactacactc tacaagtgaa ctccttgccc aggc 474 <212> Type: DNA <211> Length: 474       SequenceName: # 242       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggacaaagag cgctatgtct ccctggtgat gcctgtggcc ctgttcaacc tgattgacac 60 ttttcccttg agaaaagaag agatggtcct acaagccgaa atgagccaga cctgtaacac 120 ctgacatgat ggttcctctc ttggcaattc ctcttcattg tctacatagt gacatgcaca 180 cgggaaagcc ttaaaaatat ccttgatgta cagattttat ttgtaatttt aaaagtctat 240 tttattatga gctttctttg cacttaaaaa ttagcatgct gctttttgta cttggaagtg 300 tttcaaaaaa ttatatgacc atatttactc tttctaacct ttctttactc catcatggct 360 ggttgatttg tagagaaatt agaacccata accatacaca ggctatcaac atgttattca 420 atgtgacacc taactctttt c 441 <212> Type: DNA <211> Length: 441       SequenceName: # 243       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caaccagaag ttccacactt tcgaccgcta ccgcagccag tccacggcca agagggagaa 60 gcggtggagt gtgtcctcgg gtggggcggc cgagcggagc gtgtgcaccg ataagcccag 120 ccctggggag cgccccagct tgtcccaaca tcggcgccat cagagctgga gcaccttcaa 180 atctatgaca ctgggctcgc tgccccccaa gccccgagaa cggctgactc tgcaccgggc 240 agcagcctgg gagcccacag aaccaccgga tggtgacttc cagacagagg tgtgagtgcc 300 acgctggact gcccactgca tataaatata tatatctctc tattttcaca ctccactttg 360 gaactaccca ggagcca 377 <212> Type: DNA <211> Length: 377       SequenceName: # 244       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agccctaccg ctacacggtg aaggcgcgca acggggccgg ctgggggcct gagcgggagg 60 ccatcatcaa cctggccacc cagcccaaga ggcccatgtc catccccatc atccctgaca 120 tccctatcgt ggacgcccag agcggggagg actacgacag cttccttatg tacagcgatg 180 acgttctacg ctctccatcg ggcagccaga ggcccagcgt ctccgatgac actgagcacc 240 tggtgaatgg ccggatggac tttgccttcc cgggcagcac caactccctg cacaggatga 300 ccacgaccag tgctgctgcc tatggcaccc acctgagccc acacgtgccc caccgcgtgc 360 taagcacatc ctccaccctc acacgggact acaactcact gacccgc 407 <212> Type: DNA <211> Length: 407       SequenceName: # 245       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgcgagggca tcatcaccat agagtcccag gatggaggac ccttcccgca gctgggcagc 60 cgtgccgggc tcttccagca cccgctgcaa agcgagtaca gcagcatcac caccacccac 120 accagcgcca ccgagccctt cctagtggat gggccgaccc tgggggccca gcacctggag 180 gcaggcggct ccctcacccg gcatgtgacc caggagtttg tgagccggac actgaccacc 240 agcggaaccc ttagcaccca catggaccaa cagttcttcc aaacttgacc gcaccctgcc 300 ccacccccgc catgtcccac taggcgtcct cccgactcct ctcccggagc ctcctcagct 360 actccatcct tgcacccctg ggggcccagc ccacccgcat gcacagagca ggggctaggt 420 gtctcctggg aggcatgaag ggggcaaggt ccgtcctctg tgggcccaaa cctatttgta 480 <212> Type: DNA <211> Length: 480       SequenceName: # 246       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcctagctag aggatctgtg accccagcca tgaggaccct cgccatcctt gctgccattc 60 tcctggtggc cctgcaggcc caggctgagc cactccaggc aagagctgat gaggttgctg 120 cagccccgga gcagattgca gcggacatcc cagaagtggt tgtttccctt gcatgggacg 180 aaagcttggc tccaaagcat c 201 <212> Type: DNA <211> Length: 201       SequenceName: # 247       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagtgggct tcagatttaa ggctgacagg aagactgatg ttcatgggta aaataatact 60 gattttacta cagggagaca gaaacaacct caaggtgcca aaaagttaaa tgtttctggc 120 atttgaagtc aaagagtatt cagcgttgga tgaattacaa aaggaatttg aaactgcagg 180 acttaagaag cttttctccg aatttgtact tgctctggta aaatgaaatg gaagacagga 240 atcttttagt aaaatagcag tgttttttgt tgtttttgca ttggatttgg ggagtggtta 300 attgaaatag tcaattttaa agtttctctg aagcaaaatg ataggcatca ttctaacttc 360 aggaacaaaa gccagttctg ttttatgaaa tattaaacat gaagaaaact tgtatattct 420 aatgtttgcc aggaaaggct aggttcagta ga 452 <212> Type: DNA <211> Length: 452       SequenceName: # 248       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagccaggcc attgcgacga agaaaataat ttctgattac caccagcagt ttagatataa 60 actgcaagat ttttcagacc aactctctga ttactatgaa aaatttattg ctgaatccaa 120 aagattgatt gacctgtcca ttcaaaacta ccacacattt ctgatataca tcacggagtt 180 actgaaaaag ctgcaatcaa ccacagtcat gaacccctac atgaagcttg ctccaggaga 240 acttactatc atcctctaat tttttaaaag aaatcttcat ttattcttct tttccaattg 300 aactttcaca tagcacagaa aaaattcaaa ctgcctatat tgataaaacc atacagtgag 360 ccagccttgc agtaggcagt agactataag cagaagcaca tatgaactgg acctgcacca 420 aagctggcac cagggctcgg aaggtctctg aactcagaa 459 <212> Type: DNA <211> Length: 459       SequenceName: # 249       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctacactag agcagagtac gagtctgagg cggagggagt aatggcagga caagcgttta 60 gaaagtttct tccactcttt gaccgagtat tggttgaaag gagtgctgct gaaactgtaa 120 ccaaaggagg cattatgctt ccagaaaaat ctcaaggaaa agtattgcaa gcaacagtag 180 tcgctgttgg atcgggttct aaaggaaagg gtggagagat tcaaccagtt agcgtgaaag 240 ttggagataa agttcttctc ccagaatatg gaggcaccaa agtagttcta gatgacaagg 300 attatttcct atttagagat ggtgacattc ttggaaagta cgtagactga aataagtcac 360 tattgaaatg gcatcaacat gatgctgccc attccactga agttctgaaa tctttcgtca 420 tgtaaataat t 431 <212> Type: DNA <211> Length: 431       SequenceName: # 250       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attggaatct cctgtgcatc acatttctta aaaagagaaa tgcagaaaac caaagaacta 60 atgacaaaag tgaataaaca aaaactgttt gaaaagagta caggacttcc tcacaaagca 120 tcacgtcatc ttgacagcta tgaattcctt aaagccattt taaactgagg cattaagaag 180 aaatgcactc accatgagca ccaacttctg catctgcctg atcatattta aaggaacaga 240 gaaatatttg taattaatct gcccagtaaa taccagctcg tagcagttgg caggtgcatg 300 tctagataaa atttcttgca gctaatttaa actttctaca cgcaccagta gataatctca 360 atgtaaataa tacatttctt cttggctctt taatgtaagc caacatggag aggaagatct 420 tgacttatat tctgtaccac atacacttct gtggactttt agca 464 <212> Type: DNA <211> Length: 464       SequenceName: # 251       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccctactgt ttcgagcgtc tgggcatcct ccatctcttc ccaccatggc tgatgccctt 60 gcccatggag ctgatgtcaa ctgggtcaat gggggccaag ataatgccac accgctgatc 120 caggccacag ctgctaattc tcttctggcc tgtgagtttc tcctccagaa cggggcgaac 180 gtgaaccaag cggacagtgc gggccggggc ccgctgcacc acgcaaccat tcttggccac 240 acggggctcg cctgcctgtt cctgaaacgg ggagctgatc tgggggctcg agactctgaa 300 ggcagggacc ctctgaccat cgccatggaa acagccaacg ctgacatcgt caccctgcta 360 cgactggcaa agatgag 377 <212> Type: DNA <211> Length: 377       SequenceName: # 252       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgaaggcaga aacttcccct tgccacttcc aaacaaacct cggcccccat cccccgcgga 60 ggaagagaat tcattaaatg aagagtggta cgtttcttat attacccgac cagaggcaga 120 agctgctctt agaaagataa accaggatgg cacatttctg gtcagagaca gctctaaaaa 180 aacaacaacc aatccatatg tcctcatggt gttgtacaaa gataaagttt acaacatcca 240 gatccgttat cagaaggaaa gtcaagttta cttgttggga actggactcc gagggaaaga 300 ggactttctg tctgtgtcag atattattga ctacttcagg aaaatgccac ttctgctcat 360 tgatgggaaa aaccgaggtt ccagatacca gtgcacatta acgcatgctg cagggtaccc 420 atagcaagtt atagccgagc aaatgaaccg tcctcctgcc tctgttgcca acacgagatc 480 aatcagcctt ggtcaatgga caaacactta ggactgaact gaacccctc 529 <212> Type: DNA <211> Length: 529       SequenceName: # 253       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggatcgggca ggagttttca gtgtgttggg tgttgctcct tcctatgtgt cttttgaatc 60 tgaggctgac atttgcttgg aaggccagac ccttgctcca tcagagaggg cagtggcaaa 120 ggccagtgag gcagctgtga gttggacagg gttcaggtga gatggtgttg tcatttgtgc 180 ttagtgttgg tggtgctcag ggtggataac acgggtcgtt ctgcagcccg cttcagcaca 240 aataggcagc ttaaggcctg gctcacaggc tgtggggttg atctggctct gcagaggccc 300 taggcagctt gttgactgct gtctgttgat gacgtgtgtg caaagcaggc tctagcaaca 360 tgatcactgt ccttgccttc ctggttcttt ctctcggttg gttgccaggg cttgcagatc 420 gcagtgaatt ttccttgggg aacatcgctg ttttgtccta gagtgaactt gtggcttatg 480 gccagtgctg tttggtggtc tgccttcttt ttaat 515 <212> Type: DNA <211> Length: 515       SequenceName: # 254       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatcgtgat gtccaataca gaggcagagt ccgggtccag ctcaaacagg aagatgggag 60 cctctgcctt gtacagttcc catcacgtaa gtcagtaatg ttgtatgcag cagaaatgat 120 acctaaacta aaaacaagga cacaaaaaac aggaggtgct gaccaaagtc ttcaacaagg 180 agagggaagt aaaaaaggga aaggaaagaa aaagaagtaa cctagtatca gcatcaagta 240 tgtggtacta ctgtaagaga catgaatgga gacttctaat ttgtatcgga gggaaacaga 300 agctttttgt ttgcatcatt taactgaact gtgaaccctt gtgcctctca tctttatcat 360 cggagttgac agtgaaacaa atttacatca gaagtttgca tctcgcgtat atgccgtata 420 aaagaatttt tttgtctttc aatgcagtt 449 <212> Type: DNA <211> Length: 449       SequenceName: # 255       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cccacccgag ttgcaggatg tcgatgacag acttgctgaa cgctgaggac atcaagaagg 60 cggtgggagc ctttagcgct accgactcct tcgaccacaa aaagttcttc caaatggtcg 120 gcctgaagaa aaagagtgcg gatgatgtga agaaggtgtt tcacatgctg gacaaggaca 180 aaagtggctt catcgaggag gatgagctgg gattcatcct aaaaggcttc tccccagatg 240 ccagagacct gtctgctaaa gaaaccaaga tgctgatggc tgctggagac aaagatgggg 300 acggcaaaat tggggttgac gaattctcca ctctggtggc tgaa 344 <212> Type: DNA <211> Length: 344       SequenceName: # 256       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaaggtcca gcatgttgca tctctgcatt atcctatatc ataaaagaag cataagttat 60 catggtgttg ggtaaattag cgaaatcaac cgcttcctaa gtttaaggga aaagttattt 120 ttaaaaacaa cttaataaaa acttacactc ttatacaaga gtgtatttcc ccttaattag 180 gatgcatgtt gattaaactc gagatacagc tttttgcagt atggtgggtt ggttttggtg 240 taacatcttc aacatgtcac actggctatc aaaga 275 <212> Type: DNA <211> Length: 275       SequenceName: # 257       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaggcggctg cagaagatgt caatgttact ttcgaagatc aacaaaagat aaacaaattt 60 gcacggaata caagtagaat cacagagctg aaggaagaaa tagaagtaaa aaagaaacaa 120 ctccaaaacc tagaagatgc ttgtgatgac atcatgcttg cagatgatga ttgcttaatg 180 ataccttatc aaattggtga tgtcttcatt agccattctc aagaagaaac gcaagaaatg 240 ttagaagaag caaagaaaaa tttgcaagaa gaaattgacg ccttagaatc cagagtggaa 300 tcaattcagc gagtgttagc agatttgaaa gttcagttgt atgcaaaatt cgggagcaac 360 ataaaccttg aagctg 376 <212> Type: DNA <211> Length: 376       SequenceName: # 258       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggccacgcc aggaatattc agaaaataat gagaactaca ttgaagtgcc attgattttt 60 gatcctgtca caagagagga tttgcacatg gattttaaat gtgttgtcca taataccctg 120 agttttcaga cactacgcac cacagtcaag gaagcctcct ccacgttctc ctggggcatt 180 gtgctggccc cactttcact ggccttcttg gttttggggg gaatatggat gcacagacgg 240 tgcaaacaca gaactggaaa agcagatggt ctgactgtgc tatggcctca tcatcaagac 300 tttcaatcct atcccaa 317 <212> Type: DNA <211> Length: 317       SequenceName: # 259       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cccgggccat tgccagaaga cgtcttctcg gggcgccagg attcaccttt ccttcccgac 60 ctcaacttct tcgcggccga ctcctgtctc cagctatccg gaggcctctc ccctagccta 120 cagggttctc tcgacagccc ggtccctttt tccgaggaag agctggattt tttcaccagt 180 acgctctgtg ccatcgacct gcagtttccc taacctgttt cctcctcccg gtcctttcga 240 cccccgcgct ccttggccgt ctactggaaa aatcgagcct ctcccaccct cagtcgcata 300 gacttatgtg ttttgctaaa attcaggtat tactgaatta gcgtttaatc cacttccttt 360 cttcttcttc taaaatattg ggcactcggt tatcttttaa aattcacaca gaaaaattcc 420 gtttggtaga ctccttccaa tgaaatctc 449 <212> Type: DNA <211> Length: 449       SequenceName: # 260       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tagactgcag tggacagtcc ccaccttgtt actgctacta cactttgctc ctctggccca 60 aggcatgagg agagaggctg tgtcagaaac tgaagctgtt ctcaggatca ctgggctctt 120 cttggcagag gggatgtctg gcttgcctga agggagtggc tctgtaagga cgccttgatg 180 ctttcttcat taagattttg agcattttta cgtacttgag cttttttttt tttttttttc 240 aatttctaga ggaacttttt ctctgttaat tcctggaact gtattttgaa tccttaaagg 300 tgagccctca tagggagatc caaagtcctg tggttaacgc cttcatttat agatgaggca 360 gctgaggcct ggggatgtga acaacctgct cacagtcctc atttactgga tttgacttca 420 gccaggtgaa ctggaatgcc ttggggcgtg ga 452 <212> Type: DNA <211> Length: 452       SequenceName: # 261       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggaagctt cacatcagcc atgatatgac cgggccggac gggaaaaggg cccggaccgc 60 gtatacccgc taccagaccc tggagctgga aaaggagttc cacttcaacc gctacctgac 120 ccggcgacgg cgcatcgaga tcgcccacgc actctgcctg tccgagcgcc agatcaagat 180 ctggttccag aaccggcgca tgaagtggaa gaaggacaac aaattgaaaa gtatgagcct 240 ggctacagct ggcagcgcct tccagccctg agcccgccca gaggagccca gcggcccaag 300 agcccgtgcc acccccagcc ctggcccctc caatcctccc cgctctgccg ccgcccgctg 360 gggaccggtt cccacaagcc tgcctcgcct tgtgttacga tatttcgttt gntcttaggt 420 cttcctgtgg ctccctctct cctggactgg ttatcttgtt attattgtta ataataataa 480 ttattattat tttccttcca tgctcccaac tcccttctgc ttgtcccaaa tccgccagtg 540 tttctgaatg tttgtgtctg tggttgcagt ctttcc 576 <212> Type: DNA <211> Length: 576       SequenceName: # 262       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccccatctg tgttctaact tatttataaa agatgatcgc tgtattttga gtttcagctg 60 gaaacttctg taaggggcag cagttgaggt ggggtagtgc cgcagtgggg tcaagctgag 120 ctggcttcgg agatggagtc ccttttcatt ctcctcctcc tccctcctca ctccctaggc 180 ccaagtctcc taggggcttg gtcctagggt gggaaggggc tagggaggac caaagggatg 240 gtattgagaa gagagaaaga agatagtgag atttaagttc ctgctgcctg ggtaggcccc 300 acaaggcctg gtctgggagt atacggaaac aaaaatgatc ctcagtgcaa aatgtcttgt 360 gtatttctct gtgaatccat gggtctggct agagggccca aagcttgtaa atatggggat 420 agtctgggtc agacccatct ctcccttacc catcttgctt ccaagaccat ttgtagtgag 480 cgagtggatg ctgtgctacg tgtgaaatct gtctttgcgg ggcctgtctc agtgattcgc 540 ttttggta 548 <212> Type: DNA <211> Length: 548       SequenceName: # 263       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agagcagcct gatcttacac ggtgctgatt tcagcactaa agatgctgat aatgacaact 60 gtatgtgcaa atgtgccctc atgttaacag gaggatggtg gtttgatgct tgtggcccct 120 ccaatctaaa tggaatgttc tatactgcgg gacaaaacca tggaaaactg aatgggataa 180 agtggcacta cttcaaaggg cccagttact ccttacgttc cacaactatg atgattcgac 240 ctttagattt ttgaaagcgc aatgtcagaa gcgattatga aagcaacaaa gaaatccgga 300 gaagctgcca ggtgagaaac tgtttgaaaa cttcagaagc aaacaatatt gtctcccttc 360 cagcaataag tggtagttat gtgaagtcac caaggttctt gaccgtgaat ctggagccgt 420 ttgagttcac aagagtctct acttggggtg acagtgctca cgtggctcga ctatagaaaa 480 ctccactgac tgtcgggctt taaaaaggga agaaactgct gagcttgctg tgcttcaaac 540 tactact 547 <212> Type: DNA <211> Length: 547       SequenceName: # 264       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtttaccatc aagtcttttt tatatttatg tgtctgtatt ctaccccttt ttgccttaca 60 agtgatattt gcaggtatta taccattttt ctattcttgg tggcttcttc atagcaggta 120 agcctctcct tctaaaaact tctcaactgt tttcatttaa gggaaagaaa atgagtattt 180 tgtccttttg tgttcctaca gacactttct taaaccagtt tttggataaa gaatactatt 240 tccaaactca tattacaaaa acaaaataaa ataataaaaa aagaaagcat gatatttact 300 gttttgttgt ctgggtttga gaaatgaaat attgtttcca attatttata ataaatcagt 360 ataaaatgtt ttatgattgt tatgtgtatt atgtaatacg tacatgttta tggcaattta 420 acatgtgtat tcttttcatt taattgtttc agaataggat aattaggtat tcgaattttg 480 tctttaaaat tcatgtggtt tctatgcaaa gttcttcata tcatcaca 528 <212> Type: DNA <211> Length: 528       SequenceName: # 265       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggtggcaga catgtccaag gaatattgcg gggatttgat ccctttatga accttgtgat 60 agatgaatgt gtggagatgg cgactagtgg acaacagaac aatattggaa tggtggtaat 120 acgaggaaat agtatcatca tgttagaagc cttggaacga gtataaataa tggctgttca 180 gcagagaaac ccatgtcctc tct 203 <212> Type: DNA <211> Length: 203       SequenceName: # 266       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttgcagcctt cctacttggg ctaatcttcc ttctggtggg aatcgtcatc cagctaaggg 60 ctcagaaagg atatgtgagg acgcagatgt ctggtaatga ggtctcaaga gctgttctgc 120 tccctcagtc atgctaaggt cctcactaag cttgctctct ctggagcctg aagtagtgat 180 gagtagtctg ggccctgggt gaggtaaagg acattcatga ggtcaatgtt ctgggaataa 240 ctctcttccc tgatccttgg aggagcccga actgattctg gagctctgtg ttctgagatc 300 atgcatctcc cacccatctg cccttctccc ttctacgtgt acatcattaa tccccattgc 360 caagggcatt gtccagaaac tcccctgaga ccttactcct tccagcccca aatcatttac 420 ttttctgtgg tccagcccta ctcctataag tcatgatctc caaagctttc tgtcttccaa 480 ctgcagtctc cacagtcttc agaagacaaa tgctcaggta gtcactgttt cctttt 536 <212> Type: DNA <211> Length: 536       SequenceName: # 267       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttctttaggg ctcttcctac agccttgaga agtagatagg catcagagta tggtactata 60 ggaatcagaa aaattcaaaa caaatgtgga ttaagtgttt aggctctatg tggctcacgc 120 agccagaatc cttaagtctg tgtgtttctg tgtctcaaga ctgggctcac attctggctt 180 tgtccataac aatgctctgg gatttcaggg agttccctca tttgtaaaat gagggggtca 240 gagcaggtga tatccatgtt tcttcccttt ctgatattgt tgtctgtggc atattctttg 300 <212> Type: DNA <211> Length: 300       SequenceName: # 268       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaaggcaac gcttctcttt ctggtcaaaa tggctggtaa gcaggccgtt tcagcatcag 60 gcaagtggct ggatggtatt cgaaaatggt attacaatgc tgcaggattc aataaactgg 120 ggttaatgcg agatgataca atatacgagg atgaagatgt aaaagaagcc ataagaagac 180 ttcctgagaa cctttataat gacaggatgt ttcgcattaa gagggcactg gacctgaact 240 tgaagcatca gatcttgcct aaagagcagt ggaccaaata tgaagaggaa aatttctacc 300 ttgaaccgta tctgaa 316 <212> Type: DNA <211> Length: 316       SequenceName: # 269       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaaccgcgcc aactcatgtt gttttcaatc aggtccgcca agtttgtatt taaggaactg 60 tttcagttca taccttccac tgcgatagga atcatgtctg gtcgcggcaa aggcggaaaa 120 ggcttgggga agggtggtgc taagcgccat cgtaaggtgc tccgggataa catccagggc 180 attacaaaac cggctatccg ccgtttggct cggcgcggtg gggtcaagcg catttccggt 240 cttatctatg aggagactcg aggtgtgctt aaggttttct tagagaacgt tattcgagac 300 gccgtcacct atacggagca cgccaagcgc aaaactgtca cagccatgga tgtagtatat 360 gccctaaaac gtcaggggcg cactctgtat ggcttcggcg gctgaatcta agaatacgcg 420 gtctcctgag aacttcaaaa aacaaaaaaa cccaaaggcc cttttcaggg ccgctcacaa 480 agtcgtttaa agagctgaaa tgcgttgcga gaatgagttt ggatgacaga aataaccgtg 540 acagcctgca taa 553 <212> Type: DNA <211> Length: 553       SequenceName: # 270       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatgcgcggg aagacgttcc gctttgaaat gcagcgggat ttggtgagtt tcccgctgtc 60 tccagcggtg cgggtgaagc tggtgtctgc ggggttccag actgctgagg aactcctaga 120 ggtgaaaccc tccgagctta gcaaagaagt ggggatatct aaagcagaag ccttagaaac 180 tctgcaaatt atcagaagag aatgtctcac aaataaacca agatatgctg gtacatctga 240 gtcacacaag aagtgtacag cactggaact tcttgagcag gagcataccc agggcttcat 300 aatcaccttc tgttcagcac t 321 <212> Type: DNA <211> Length: 321       SequenceName: # 271       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggtcagaga cagaacctcc ttccagctac tcaatcctgg aacgtacaca gtacaaataa 60 gagcccggga aagagtgtat gaattcttga gcgcctggag caccccccag cgcttcgagt 120 gcgaccagga ggagggcgca aacacacgtg cctggcggac gtcgctgctg atcgcgctgg 180 ggacgctgct ggccctggtc tgtgtcttcg tgatctgcag aaggtatctg gtgatgcaga 240 gactctttcc ccgcatccct cacatgaaag accccatcgg tgacagcttc caaaacgaca 300 agctggtggt ctgggaggcg ggcaaagccg gcctggagga gtgtctggtg actgaagtac 360 aggtcgtgca gaaaacttga gactggggtt cagggcttgt gggggtctgc ctcaatctcc 420 ctggccgggc caggcgcctg cacagactgg ctgctggacc tgcgcacgca gcccaggaat 480 ggacattcct aacgggtggt gggca 505 <212> Type: DNA <211> Length: 505       SequenceName: # 272       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctgtgcagc tccgatttta ttcgcatcct tgtgatcttc tctggaatgt tccttgtttt 60 caccctggcc ggggccctgt tcctccatca acgaaggaaa tatagatcaa acaaaggaga 120 aagtcctgtg gagcctgcag agccttgtcg ttacagctgc cccagggagg aggagggcag 180 caccatcccc atccaggagg attaccgaaa accggagcct gcctgctccc cctgagccag 240 cacctgcggt agctgcacta cagccctggc ctccaccccc accccgccga ccatccaagg 300 gagagtgaga cctggcagcc acaactgcag tcccatcctc ttgtcagggc cctttcctgt 360 gtacacgtga cagagtgcct tttcgagact ggcagggacg aggacaaata tggatgaggt 420 ggagagtggg aagcaggagc ccagccagct gcgcctgcgc tgcaggaggg cgggggctct 480 ggttgtaaaa cacacttcct gctgcgaaag acccacatgc taca 524 <212> Type: DNA <211> Length: 524       SequenceName: # 273       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacacagcag ttgcaataac cttggcttgt ttcggacttg ctcgggaggg taatcacaag 60 cctattgact accttaaccc acctaagtaa atgtggaaac atccgatata aatctcatag 120 ttaatggcat aattagaaag ctaatcattt tcttaagcat agagttatcc ttctaaagac 180 ttgttctttc agaaaaatgt ttttccaatt agtataaact ctacaaattc cctcttggtg 240 taaaattcaa gatgtggaaa ttctaacttt tttgaaattt aaaagcttat attttctaac 300 ttggcaaaag acttatcctt agaaagagaa gtgtacattg atttccaatt aaaaatttgc 360 tggcattaaa aataagcaca cttacataag cccccataca tagagtggga ctcttggaat 420 caggagacaa agctaccaca tgtggaaagg tactatgtgt ccatgtcatt 470 <212> Type: DNA <211> Length: 470       SequenceName: # 274       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttccggggg cttacggagc tggtggagtt ttaccagcag aactctctaa aggattgctt 60 caagtctctg gacaccacct tgcagttccc cttcaaggag cctgaaaaga gaaccatcag 120 caggccagca gtgggaagca caaagtattt tggcacagcc aaagcccgct atgacttctg 180 cgcccgagac cgatcagagc tgtcgctcaa ggagggtgac atcatcaaga tccttaacaa 240 gaagggacag caaggctggt ggcgagggga gatctatggc cgggttggct ggttccctgc 300 caactacgtg gaggaagatt attctgaata ctgctgagcc ctggtgcctt ggcagagaga 360 cgagaaactc caggctctga gcccggcgtg ggcaggcagc ggagccaggg gctgtgacag 420 ctcccggcgg gtggagactt tgggatggac tggaggagcg cagcgtccag ctggcggtgc 480 tcccgggatg tgccctgaca tggttaat 508 <212> Type: DNA <211> Length: 508       SequenceName: # 275       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attgcaccca tgaatgtggc taggcgagga gctggagtgg ctgttcttaa tggaaaactg 60 tttgtatgtg gtggctttga tggttctcat gccatcagtt gtgtggaaat gtatgatcca 120 actagaaatg aatggaagat gatgggacat atgacttcac caaggagcaa tgctgggatt 180 gcaactgtag ggaacaccat ttatgcagtg gaggattcga tggcaatgaa tttctgaata 240 cggcggaagt ctataacctt gagtcaaatg aatggagccc ctatacaaag attttccagt 300 tttaacgggt ttaagaccct ctcaaactaa caggcttagt gatgtaatta tggttagcag 360 aggtacactt gtgaataaag agggtgggtg gggatagatg ttgctaacag caacacaaag 420 cttttgcata ttgcatacta ttaaacatgc tgtacatact ttttgggtt 469 <212> Type: DNA <211> Length: 469       SequenceName: # 276       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccatctggac cataataggg acaccaaaac aaacccaaat tggtaaaaag aataatcaaa 60 aagaagacat tatccggtta agagtctgtg ctggttgcca cnnaagagag aacagttgtc 120 caggatgctg gctggtggaa caacctgctg gcccgaaaca aggctgccag gtgtggaaca 180 gcccatgctg actggggaca tacacttgca tctttgttga aagcagaaga agacagaccc 240 tttccccacc ttccttacct cctcttcccc cattaaggca gctcatccaa gcttgtattt 300 aactgaataa atgagtagac attgtggacc tcacaagatt atttaattct taagatgtgt 360 agaccttgat ggtaggtgtg acatgttagt ttttcttact tgcatttatt taagacacac 420 tgttacagag atactgttgt caccttctgg ggcacggtct ttggggagag gggagtgcat 480 ttagacttat gtgg 494 <212> Type: DNA <211> Length: 494       SequenceName: # 277       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagctgcgga actctgaacg ggcgcgggag gatgcggaga ggaggaacca gctgttgcag 60 agggaaatgg aggagttttt ttcgacccta ggaagcttga ctgttggggc aaaaggtgcc 120 agggccccaa agtaaaagga atggcagagc tcacttctgt accacgtctg ctggtctcca 180 gccttgtatg gagttagaag cgtctgtatc tctggagcag ccaggcgctc tggagccagc 240 tggagagaga gagatcctga tacctctgtg gggactgtgg ggacttttgg gaccccacac 300 actccaggtg ggatcagatg ctgctccaac catgcagttc ctggtgaggg tcagaagggg 360 acggtaccaa gagcagcgct tagcccttac ccaggaaata tccttcatgg ccacagaaat 420 ggagggcgcc caggatccag gcagccaccg ggaacagtca gctttcttta 470 <212> Type: DNA <211> Length: 470       SequenceName: # 278       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagcatatc cagagggcga aagatatctc tccattgtgc atctgcctct tttgacgttg 60 gaagacacat gtcttactcc ccaaagggag cccagcactg ggagccttct tgatgatctc 120 aaaaataata gctattcaag aaaatcacca agtgactgtg aaaccgtcag ttcggaaggc 180 tggttagaac atgtgggagc aacatgaatg ttctacaaaa gtttaaagca gagattgttt 240 caaatgggtg tagtagatat tactgaaaac caaaaaagag tgagattgtc agtgtaagaa 300 tgtgatttaa tgtttgtagt gcttacaatt ttgtgtacca actggatgac taaaaagagt 360 aaaataactt aattaatagc tcatatttta tgtgtgaaaa catgttagtg aacatatata 420 atcaaaatag atttcattgc tattgcatag tctc 454 <212> Type: DNA <211> Length: 454       SequenceName: # 279       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgagcctggg gttctggtgt tagaatattt ttaagtaggc tttactgaga gaaactaaat 60 attggcatac gttatcagca acttcccctg ttcaatagta tgggaaaaat aagatgactg 120 ggaaaaagac acacccacac cgtagaacat atattaatct actggcgaat gggaaaggag 180 accattttct tagaaagcaa ataaacttga tttttttaaa tctaaaattt acattaatga 240 gtgcaaaata acacataaaa tgaaaattca cacatcacat ttttctggaa aacagacgga 300 ttttacttct ggagacatgg catacggtta ctgacttatg agctaccaaa actaaattct 360 ttctctgcta ttaactggct agaagacatt catctatttt tcaaatgttc tttcaaaaca 420 tttttataag taatgtttgt atctatttca tgctttact 459 <212> Type: DNA <211> Length: 459       SequenceName: # 280       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatggccgtg tttcggaatg tcctcacacc taccaaaaca ggcgaccttt cagcagagag 60 atggatttgg ggctactctc tccgcaggct caggtcgaag attcgtagag gaacaattta 120 gttttaagga cttcatccct ccacctatcc ctaacaggct gtagattacc aaaacaagat 180 taatttcatc actaaaagaa aatctattat caactgctgc ttcaccagac ttttctctag 240 aagccgtctg cgtttactct tgttttcaaa gggacttttg taaaatcaaa tcatcctgtc 300 acaaggcagg aggagctgat aatgaacttt attggagcat tgatctgcat ccaaggcctt 360 ctcaggccgg cttgagtgaa ttgtgtacc 389 <212> Type: DNA <211> Length: 389       SequenceName: # 281       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcaggacaa ggtctggcat ggcacagcac cactgccagg cctccccagg cacaccactc 60 tgcccaggga atgggggctt tgggtcatct cccactgcct gggggagtca gatggggtgc 120 aggaatctgg ctcttcagcc atctcaggtt tagggggttt gtaacagaca ttattctgtt 180 ttcactgcgt atccttggta agccctgtgg actggttcct gctgtgtgat gctgagggtt 240 ttaaggtggg gagagataag ggctctctcg ggccatgcta cccggtatga ctgggtaatg 300 aggacagact gtggacaccc catctacctg agtctgattc tttagcagca gagactgagg 360 ggtgcagagt gtgagctggg aaaggtttgt ggctccttgc agcc 404 <212> Type: DNA <211> Length: 404       SequenceName: # 282       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaacttactt cagattgtgc gggaccactg ggttcatgtt cttgtcccta tgggatttgt 60 cattggatgt tatttagaca gaaagagtga tgaacggcta actgccttcc ggaacaagag 120 tatgttattt aaaagggaat tgcaacccag tgaagaagtt acctggaagt aaagactggc 180 tagattatcg aatgttcaca ttttaaagtt ctgagaga 218 <212> Type: DNA <211> Length: 218       SequenceName: # 283       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcatcatccc ttttgcttat ggtagtgggc taacataaca gcccctttct caagcagaga 60 cctggcccct gggccagcca gatggaaggg cctatcttag ccagctggag cttaagccaa 120 acctgttctg tcccactggc cagccatctt tgctcacatg gaaattcaaa tgccattcaa 180 aggccactgg tgctttattt ttctatctgc tgagtaaact gaaatgagat gggtcccaac 240 caccactgta attttcaagc ctattttatt tgtacctgta aatactgtac agctaatata 300 tatatatata tatatatata tatgtgtgtg tgtgtgtgtg tgtatgtgtg tttatagaga 360 tacacacaca tatatatgtg tgtatatata tacacataca tatatataca cacacgcatt 420 tgcacagaca cacacatata tcaattctca tgagtgtatt ataatctctg gtgggggcaa 480 gtgtctggaa ggcctgaggg gcacttcaga tgagaatgga gaggtaggga gccaggtgca 540 gca 543 <212> Type: DNA <211> Length: 543       SequenceName: # 284       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagggtctc tgatttcttg agcatcagcg agtttcagaa gtgactattt ttttgtactc 60 ttctagtttc cttgtaacta tacacttttt cccattccac actgtgctta aatgacaaag 120 actcttctga gaagccaaat tctgtccaag tattaactag agatattgtt gattaaagaa 180 aatctagaac tgaagtgaaa gaagagagtt ccagttctaa tagtcttttg attaacaatt 240 cttttctgag aaatgatttt tataagaaat ggggtgattc tttaaatgct tttcttaagt 300 tgaaggcaca acagttaatg gctgtattgt tgctattccg ttgctgacat gtttttgata 360 aagctttaac attcctgcta ctaattttgg cggagagtgt ttgccaggtt tcaatgtggg 420 ctgcagcttt ttgtgctcct tctctggttt gcagtgtaat gagttcataa gctaaatttt 480 cagaaagaat tttgtttaag attatgcctc ttatctactt gagagcaaca tgtcttttca 540 atcat 545 <212> Type: DNA <211> Length: 545       SequenceName: # 285       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagtgtgagt cctgaagcac tttcagtgct gtgagaacga catccacttt gggtttcatt 60 cgtttgtaag cagaggagct gtcagtcact cgtgcttctc ggtggcctct gagccatggt 120 gtcgagtgaa gagtagttct tgtttgttac aacctttgtg agtcagccat gcccgcaaag 180 cgtgctgtgt tttag 195 <212> Type: DNA <211> Length: 195       SequenceName: # 286       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcagttcctc ccaattctag gttctgggcc aaaatgcgct accacatgcc tgtgaaaaac 60 tctcagggat tcacgtggaa ccagctcaga attacctcta ggatttttca gtggaaagga 120 ctcagtagaa cagaaaccac tgggaggagc tcccagccta aggaatggtg aaatgagccc 180 tggagccccc tccagtccag tccctgggat agagatgttg ctggacagaa ctcacagctc 240 tgtgtgtgtg tgttcaggct gataggaaat tcaaagagtc tcctgccagc accaagcaag 300 cttgatggac aatggaatgg gattgagact gtggtttaga gcctttgatt tcctggactg 360 gacagacggc gagtgaattc tctagacctt gggtactttc agtacacaac acccctaaga 420 tttcccagtg gtccgagcag aatcagaaaa tacagctact tctgccttat ggctagggaa 480 ctgtcatgtc tacca 495 <212> Type: DNA <211> Length: 495       SequenceName: # 287       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tctgctcaac ggccaggtac gagaagaata caagaggtgg atcactggga agacgaagcc 60 cagctcccag tcccagacct caaggatctt gctgtcctcc atgccatccg cttccaagac 120 gggttaaagc ctttcttgct ttcaaatatg ctatggagcc acagttgagg acagtagttt 180 cctgcaggag cctaccctga aatctcttct cagcttaaca tggaaatgag gatcccacca 240 gccccagaac cctctgggga agaatgttgg gggccgtctt cctgtggttg tatgcactga 300 tgagaaatca gacgtttctg ctccaaacga ccattttatc ttcgtgctct gcaacttctt 360 caattccaga gtttctgaga acagacccaa attcaatggc atgaccaaga acacctggct 420 accattttgt tttctcctgc ccttgttggt gcatggttct aagcgtgccc ctccagcgcc 480 tatcatacgc ctgacacaga gaacctctca ataaatgatt tgtcgcctgt ctgactgatt 540 <212> Type: DNA <211> Length: 540       SequenceName: # 288       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgcagtagc tgccatgtct aaagataaaa ataacatgca acatcgatat attgaactct 60 tcttgaattc tactcctgga ggcggctctg gcatgggagg ttctggaatg ggaggctacg 120 gaagagatgg aatggataat cagggaggct atggatcagt tggaagaatg ggaatgggga 180 acaattacag tggaggatat ggtactcctg atggtttggg tggttatggc cgtggtggtg 240 gaggcagtgg aggttactat gggcaaggcg gcatgagtgg aggtggatgg cgtgggatgt 300 actgaaagca aaaacaccaa catacaagtc ttgacaacag catctggtct actagacttt 360 cttacagatt 370 <212> Type: DNA <211> Length: 370       SequenceName: # 289       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaccagatg caacctcact atggtatgct ggccagcacc ctctcctggg ggtggcaggc 60 acacagcagc cccccagcac taaggccgtg tctctgagga cgtcatcgga ggctgggccc 120 ctgggatggg accagggatg ggggatgggc cagggtttac ccagtgggac agaggagcaa 180 ggtttaaatt tgttattgtg tattatgttg ttcaaatgca ttttgggggt ttttaatctt 240 tgtgacagga aagccctccc ccttcccctt ctgtgtcaca gttcttggtg actgtcccac 300 cggagcctcc ccctcagatg atctctccac ggtagcactt gaccttttcg acgcttaacc 360 tttccgctgt cgccccaggc cctccctgac tccctgtggg ggtggccatc cctgggcccc 420 tccacgcctc ctggccagac gctgccgctg ccgctgcacc acggcgtttt tttacaacat 480 <212> Type: DNA <211> Length: 480       SequenceName: # 290       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atttacaggt tcttaggctc catcctgttt gtatgaaatt ataatctgtg gattggcctt 60 taagcctgca ttcttaacaa actcttcagt taattcttag atacactaaa aatctgagaa 120 actctacatg taactatttc ttcagagttt gtcatatact gcttgtcatc tgcatgtcta 180 ctcagcattt gattaacatt tgtgta 206 <212> Type: DNA <211> Length: 206       SequenceName: # 291       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caagtatcgg ggctctgcta tcaaggtgca aagtccttcg tggatgcaac ctcaaccata 60 tattctacag caccctggtg ccgtgttaac tccctcaatg gagcacacca tgtcactaca 120 gcccgcatca atgatcagcc ctctggccca gcagatgagt catctgtcac taggcagcac 180 cggaacatac atgcctgcaa cgtcagctat gcaaggagcc tacttgccac agtatgcaca 240 tatgcagacg acagcggttc ctgttgagga ggcaagtggt caacagcagg tggctgtcga 300 gacgtctaat gaccattctc catatacctt tcaa 334 <212> Type: DNA <211> Length: 334       SequenceName: # 292       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctgtcaga tggccttgag cggcaccaag tagaaaacgc gctcccaccc ctgaccttct 60 cctcagcttc attgtgagac ctcaagttcc tcagcttcca ggatgatcaa cctagctgaa 120 aacctgaagt ccctcccggt acaagtccaa gcagtcccca gccagggaga ccaggtgttg 180 tctgacatcc cacacacatc ggcacacttg ggggattgca aaagggagga agggagccaa 240 aggctagggc cccggggttc agctaacact cagcacccct cccaaagagc gccccctgtg 300 tgttctggat ctctagaggg gtttggtttg ggccaagtag tgcttagttt taattttctc 360 tttctggaaa taaatacttt taataagtaa agatgctgct cagctgtcat atcctgcaag 420 gttagaggaa agatgtgggc cgtgcgcg 448 <212> Type: DNA <211> Length: 448       SequenceName: # 293       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcactgcagc cagcattggg gcagctggca tcccccaggc cggcctcgtc accatggtca 60 tcgtgctcac ctccgtggga ctgcccaccg atgacatcac cctcatcatt ggcgttgact 120 gggctctgga ccgtttccgc accatgatta acgtgctggg tgatgcgctg gcagcgggga 180 tcatggccca tatatgtcgg aaggattttg cccgggacac aggcaccgag aaactgctgc 240 cctgcgagac caagccagtg agcctccagg agatcgtggc agcccagcag aatggctgtg 300 tgaagagtgt agccgaggcc tccgagctca ccctgggccc cacctgcccc caccacgtcc 360 ccgttcaagt ggagcgggat gaggagctgc ccgctgcgag tctgaaccac tgcaccatcc 420 agatcagcga gctggagacc aatgtctgag cctgcggagc tgcaggggca ggcgaggcct 480 ccaggggcag ggtcctgagg caggaactcg actctc 516 <212> Type: DNA <211> Length: 516       SequenceName: # 294       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctgcgcaa ttactactat gacgtggtga actaaccgct cccgcacctg tcggtggctg 60 cctttgatca caggagcaat cacaggaaaa tgtatccaga ggaattgatt gtcagccacc 120 tccctctgcc agtcgggaga gccaggcttg gatggaacat gcccacaact tgtcacccaa 180 agcctgtccc aggactcacc ctccacaaag caaaggcagt cccgggagaa aagacggatg 240 gcaggatcca aggggctagc tggatttgtt tgttttcttg tctgtgtgat tttcatacag 300 gttattttta cgatctgttt ccaaatccct ttcatgtctt tccacttctc tgggtcccgg 360 ggtgcatttg ttactcatcg ggcccaggga cattgcagag tggcctagag cactctcacc 420 ccaagcggcc ttttccaaat gcccaaggat gccttagcat gtgactcctg aagggaaggc 480 aaaggcagag gaatttggct gcttctacgg cc 512 <212> Type: DNA <211> Length: 512       SequenceName: # 295       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtggtgggt ctttacccac agcgcaaaca caatgcccac cttggggctc tgttgtttga 60 gttgcccaca tactgcagtt attctgttag gaatgattcc ctgggtgcct gaaagtgctc 120 tgacacgaca cttgttactt tgcaggccat ctgtgatggc aaggaaaaag caactatgtt 180 cacagtgaaa tattcgtgga ataggttagg ccattcagta gacattgcag ttagttagca 240 agaaccacat tgtctcttta tttgttagca ttaaacaaat ttttttttgc aaattggttt 300 tatttttttg atgaagccga gcaactctgt ccaaaaaggt ttagtttgta ctcggaaacc 360 acaaagtagt ctcaaagtat tttagaggga atcgatattg atggcaaaag aaaatttgca 420 gctatgcatt tgcttctaac ggttccctct ctgtgaaaca ttatttttgg tgatctaaag 480 aaagcattgc ctttcttatt tgagatttta cagctatact ttgttgtgta atgttatggt 540 tccctttctg ta 552 <212> Type: DNA <211> Length: 552       SequenceName: # 296       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgaagacag ttttcctgaa gctgctgccc caggtcctgc tgatgaggtg gcctctggac 60 aagacaaggg gcacaggctc tgatgcagtg cccagaggcc ttgccaggag gcctgccaaa 120 ggcaagcttg caagccatgg ggaacccaga catcttaaag aatgcttcca ttgtcacaaa 180 tcaaatgagc ttgccacaag caagagaaga ttaagtcatc agccattaca gtgggtggtg 240 gaaaattcgg agcactcgcc tgaagttgaa gatgtgatta acagtgttca gttcatagca 300 gaaaacatga agagccacaa tgaaaccaag gaggtagaag atgactggaa atacgtggcc 360 atggtggtgg acagagtatt tctttgggta tttataattg tctgtgtatt tggaactgca 420 gggctatttc tacagccact acttgggaac acaggaaaat cttaaaatgt attttctttt 480 atgttcagaa atttacagac accatatttg ttctgcattc cctgccacaa ggaaagg 537 <212> Type: DNA <211> Length: 537       SequenceName: # 297       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcttccttca ggttctagat tcttgctact tagggcgggc tggtttggac ctaacatctc 60 gcacgtgact ccctcagcct cagagccttg ggatgcagag cagctggcag ggttcctctc 120 aatcctgcaa ccccagctgt cccaccggtg gatgcagagg ggaatccgag gccatcaacc 180 ttggtgacag cagcgcagtg ccaatgctga tcacactgca tgggagattt tgttaacgtc 240 tgccaccccc actctcaccc ccaagctcta agcccccggg aggcctggac tgtcttcctc 300 atctctgtag caccaagcct gatagatctg tatatggtaa acaggggttt aaccacatgt 360 ggttaacatg gattaatgtg ggaatttggc ttcaagaaca caaccttagg accttgggcc 420 ccaaaagctg gtggtgaaat gagaggagcc aatttaagaa gacccttatg gagacctgag 480 gctgc 485 <212> Type: DNA <211> Length: 485       SequenceName: # 298       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttttggtga cattcagccg ggggttcggg gggacggacc tccattccaa aaccatgggc 60 caatttgtcc gtaaccttgt ggaaaaaacc ccggcgctgg tgaacgctgc tgtgacttac 120 tcgaagcctc gattggccac attttggtac tacgccaagg ttgagctggt tcctcccacc 180 cctgctgaga tccctaaagc tattcagagc ctgaaaaaaa tagtcaatag tgctcaaact 240 ggtagcttca aacagctcac agttaaggaa gctgtgctga atggtttggt ggccactgag 300 gtgttgatgt ggttttatgt cggagagatt ataggcaagc ggggcatcat tggctatg 358 <212> Type: DNA <211> Length: 358       SequenceName: # 299       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaagcattca gcaaatggca ccctaaaata tgccgctggt ttgccactga cttcaaaatg 60 aggtcacttg ggcacagcac atgcagggag gggcttttct ctgagcctcc ttcatctgcc 120 caaagacaaa tcctcaaaag gaaattcaat catcatgaat cacaacccca agtatctcat 180 cagccaggga agagtaagtg ggatcacagg gaaggatgtt ggcagcgaca ccatcccata 240 caggctctta cctcttctcc tgagggctgc tccagacaac atttattacc cagaagacct 300 tttgtctgaa aaccagccaa gctttattca ggacacactt cttgccttca ctttcccact 360 tccgtggcca cctccatgca gaagccctaa gcccacattc tttcaatagc tcacggtggt 420 gcatgagtgt ccatcatctg actcttctcg gagtctcata ttttgtggga 470 <212> Type: DNA <211> Length: 470       SequenceName: # 300       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaacttgtca tctccaacga caaaaggagc ttttgccact gactcggccg tgtcctgaca 60 cctccagaac gcaggtgctg gcgcccgttc tgcctgggac cccgggaacc tctcctgccg 120 gaagccggac ggcagggatg ggccccaact tcgccctgcc cacttgactt caccaaatcc 180 cttcctggag actgaacctg gtgctcagga gcgaaggact gtgaacttgt ggcctgaaga 240 gccagagcta gctctggcca ccagctgggc gacgtcaccc tgctcccacc ccaccccaag 300 ttctaaggtc ttttcagagc gtggaggtgt ggaaggagtg gctgctctcc aaactatgcc 360 aaggcggcgg cagagctggt cttctggtct ccttggagaa aggttctgtt gccctga 417 <212> Type: DNA <211> Length: 417       SequenceName: # 301       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatctgatga aagctatact ccaagcaaga tctcagtcag agtaggaaat aattttcaca 60 acctacaaga aattcggcaa cttgagttgg tggaaccaag tggctggatt catgttccct 120 taactgacaa tcataagaag ccaactcgtt cattcatgat acagattgct gttctagcca 180 atcacctgaa tggaagagac acccatatga gacaaattaa aatatacaca ccagtagaag 240 agagctccat tggtaaattt cctagatgta caactataga tttcatgatg tatcgttcaa 300 taaggtgact ttaaaatgag acgaaaatca ttaaacgtat ctttgtttta tcctgtattc 360 aaataatata tcatgtacct ttattgaaca aggcatccgt tatatctaat tt 412 <212> Type: DNA <211> Length: 412       SequenceName: # 302       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagaacacgg tggcagagac ggagtgccgc tatgccctgc agctgcagca gatccaggga 60 ctcatcagca gcatcgaggc ccagctgagc gagctccgca gtgagatgga gtgccagaac 120 caagagtaca agatgctgct ggacatcaag acacgtctgg agcaggagat cgccacctac 180 cgcagcctgc tcgagggcca ggacgccaag aagcgtcagc ccccgtagca cctctgttac 240 cacgacttct agtgcctctg ttaccaccac ctctaatgcc tctggtcgcc gcacttctga 300 tgtccgtagg ccttaaatct gcctggcgtc ccctccctct gtcttcagca cccagaggag 360 gagagagccg gcagttccct gcaggagaga ggaggggctg ctggacccaa ggctcagtcc 420 ctctgctctc aggaccccct gtcctgactc tctcctgatg gtgggccctc tgtgctcttc 480 tcttccggtc ggatctctct cctctctgac ctggatacgc tttggtttct caacttc 537 <212> Type: DNA <211> Length: 537       SequenceName: # 303       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: accgaacacc atgccttcaa ttaagttgca gagttctgat ggagagatat ttgaagttga 60 tgtggaaatt gccaaacaat ctgtaactat taagaccatg ttggaagatt tgggaatgga 120 tgatgaagga gatgatgacc cagttcctct accaaatgtg aatgcagcaa tattaaaaaa 180 ggtcattcag tggtgcaccc accacaagga tgaccctcct cctcctgaag atgatgagaa 240 caaagaaaag cggacagatg atatccctgt ttgggaccaa gaattcctga aagttgacca 300 aggaacactt tttgaactca ttctggctgc aaactactta gacatcaaag gtttgcttga 360 tgttacatgc aagactgttg ccaatatgat caaggggaaa actcctgagg agattcgcaa 420 gaccttcaat atcaaaaatg actttactga agaggaggaa gcccaggtac gcaaagag 478 <212> Type: DNA <211> Length: 478       SequenceName: # 304       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacaactgcg tgggtccaaa cactcctctt cctccaggtc atttgttttg catttttaat 60 gtctttattt tttgtaatga aaaagcacac taagctgccc ctggaatcgg gtgcagctga 120 ataggcaccc aaaagtccgt gactaaattc cgtttgtctt tttgatagca aattatgtta 180 agagacagtg atggctaggg ctcaacaatt ttgtattccc atgtttgtgt gagacagagt 240 ttgttttccc ttgaacttgg ttagaattgt gctactgtga acgctgatcc tgcatatgga 300 agtcccactt tggtgacatt tcctggccat tcttgtttcc attgtgtgga tggtgggttg 360 tgcccacttc ctggagtgag acagctcctg gtgtgtagaa ttcccggagc gtccgtggtt 420 cagagtaaac 430 <212> Type: DNA <211> Length: 430       SequenceName: # 305       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatggccagg cctttgactg tggatgagat tgtgggccag gccttcatct tcctcatcgc 60 tggctatgaa atcatcacca acacactttc ttttgccacc tacctactgg ccaccaaccc 120 tgactgccaa gagaagcttc tgagagaggt agacgttttt aaggagaaac acatggcccc 180 tgagttctgc agcctcgagg aaggcctgcc ctatctggac atggtgattg cagagacgct 240 gaggatgtac ccgccagctt tcagattcac acgggaggca gctcaggact gcgaggtgct 300 ggggcagcgc atccccgcag gcgctgtgct agagatggcc gtgggtgccc tgcaccatga 360 ccctgagcac tggccaagcc cggagacctt caaccctgaa aggtaccgct gcagctagaa 420 tccaaatctg ccctaggtcc aaaaaatggt gtctatatca agatcgtatc ccgctgacac 480 agaaggctgc cgg 493 <212> Type: DNA <211> Length: 493       SequenceName: # 306       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagtataca cttccgctgt accacgcaat gatgggtggc agtgaggtgg cccagaccct 60 cgccaaggag acttttgcat ccaccgcctc ccagctccac agcaatgttg tcaactatgt 120 ccagcagatc gtggcaccca agggcagtta gaggctcgtg tgcatggccc ctgcctcttc 180 aggctctcca ggctttcaga ataattgttt gttcccaaat tcctgttccc tgatcaactt 240 cctggagttt atatcccctc aggataatct attctctagc ttaggtatct gtgactcttg 300 ggcctctgct ctggtgggaa cttacttctc tatagcccac tgagccccga gacagagaac 360 ctgcccacag ctctccccgc tacaggctgc aggcacgcag ggcagcgggt attctcctcc 420 cacctaagtc tctgggaaga agtggagagg actgatgctc ttctt 465 <212> Type: DNA <211> Length: 465       SequenceName: # 307       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggcacatcg aacctgagtt agcaggaagg gattctccaa taagagcaga aatgccagga 60 aatcctcaac actatggaag atttcttacc ggacccttga acctcaatga tccagatgca 120 aaatgcagat tccccaaaat ttttgtaaat acagatgaca cttatgaaga gctccattta 180 atcgtttata aggccatgag tgcggctgtg tgctttatga tcgacgcctc tgtccaccca 240 acgttggatt tttgccgaag actggacagc atcgttggcc cccagctcac agtgctgccc 300 tctgacatct gtgaacagtt taacatcaac aagaggatgt ccgggtctga gaaagaaccc 360 cagtttaag 369 <212> Type: DNA <211> Length: 369       SequenceName: # 308       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagagtggtc agatgtttgc caaggaagat ttgaaacgga agaagcttgt acgtgatggg 60 agtgtgtttc tgaagaatgc agcaggaagg ttgaaagagg ttcaagcagt tcttctcact 120 gacattttag ttttccttca agaaaaagac cagaagtaca tctttgcatc attggaccag 180 aagtcaacag tgatctcttt aaagaagctg attgtgagag aagtggcaca tgaggagaaa 240 ggtttattcc tgatcagcat ggggatgaca gatccagaga tggtagaagt ccatgccagc 300 tccaaagagg aacg 314 <212> Type: DNA <211> Length: 314       SequenceName: # 309       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacacacctg tgatgggaaa gggcgaacga ggattagggg atggggagga agagagagac 60 tgtggagctc tggggggcaa cctggaggtc tgaaaagagg agccagagaa ggtggtaccc 120 aggcttcctg gtcagaaccg gcctggagct ccttcccttc cccctggcct gagaggttgc 180 ttttaagtct tccacccctt gttccatctg cctgccaacc catcggaaag gaatccacat 240 catattggag 250 <212> Type: DNA <211> Length: 250       SequenceName: # 310       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgagacgttc tctttggtgg tcaacccgga tgggtgacag gctggatggc cttgtgaact 60 tgagctcagt gtatgctagg caacaattct cccgctccag accctcaccg accacctgtc 120 ctgggaccag gctgggaggg gagtgtggca gggaggagga agaggaaggt gagaatgagt 180 agaacagttt tgtattctac tccctacaag ccattttgaa cttctgccct caccggactc 240 tgggctgtga ctggggcacc aaactcagca catgagtctc ccctagctct cgtggggaga 300 gggatgctat ttattcagtt tggggcagga gggagaggag ggaaagtatt tctgaccctg 360 atgccaacag ccgggtggct gtccaagcag gattgcaggg gacacaggga agcactgccc 420 agcccctgcc tggctgccct ttcccccctg ctgctgccac cgcttcctgc ctgtcatttg 480 aataaa 486 <212> Type: DNA <211> Length: 486       SequenceName: # 311       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtcagacg cagccgtaga caccagctcc gaaatcacca ccgaggactt aaaggagaag 60 aaggaagttg tggaagaggc ggaaaatgga agagacgccc ctgctgacga ggaaaatggg 120 gagcaagagg ctgacaatga agtagatgaa gaacaggaag aaggtgggga ggaagaaggt 180 gatggtgagg aagaggatgg agatgaagat gagggagctg agtcagctac ggacaagcgg 240 gcagctgaag atgatgagga taacgatgtc gataccaaga agcagaagac cgacgaggat 300 gactag 306 <212> Type: DNA <211> Length: 306       SequenceName: # 312       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatgacagg agccatccgc aagcagttgg cggctttctt agaaggcttc tatgagatca 60 ttccaaagcg cctcatttcc atcttcactg agcaggagtt agagctgctt atatcaggac 120 tgcccaccat tgacatcgat gatctgaaat ccaacactga ataccacaag taccagtcca 180 actctattca gatccagtgg ttctggagag cattgcgttc tttcgatcaa gctgaccgtg 240 ccaagttcct ccagtttgtc acgggtactt ccaaggtacc cctgcaaggc tttgctgccc 300 tcgaaggcat gaatggcatt cagaagtttc agatccatcg agatgacagg accctaccca 360 agattgggaa cacaaatgtg gctgagtcct ggaccttggg taactcacaa tttggtgttt 420 ctatggaggt gatgtttgag atgagatgtg ctagacacag tgggggctgg ggagacactg 480 tcagttttaa tcagctggat ctgcctgcct atgagagctt tgagaagctc cgccacatgc 540 tactgttggc tatccaggag tgctctgaa 569 <212> Type: DNA <211> Length: 569       SequenceName: # 313       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taaagactat cggcctccgg gaagtgtggt actttggcct ccactatgtg gataataaag 60 gatttcctac ctggctgaag ctggataaga aggtgtctgc ccaggaggtc aggaaggaga 120 atcccctcca gttcaagttc cgggccaagt tctaccctga agatgtggct gaggagctca 180 tccaggacat cacccagaaa cttttcttcc tccaagtgaa ggaaggaatc cttagcgatg 240 agatctactg cccccctgag actgccgtgc tcttggggtc ctacgctgtg caggccaagt 300 ttggggacta caacaaagaa gtgcacaagt ctgggtacct cagctctgag cggctgatcc 360 ctcaaagagt gatggaccag cacaaactta ccagggacca gtgggaggac cggatccagg 420 tgtggcatgc ggaacaccgt gggatgctc 449 <212> Type: DNA <211> Length: 449       SequenceName: # 314       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaggaccca caatgacatc atccacaacg agaacatgag gcaaggccgg gacaagtaca 60 agacgctgcg gcagatccgg cagggcaaca ccaagcagcg catcgacgag ttcgaggccc 120 tgtaacagcc aggccaggac caagggcaga ggggtgctca tagcgggcgc tgccagcccc 180 gccacgcttg tnnctttagt gctccaagtc taggaactcc ctcagatccc agttccttta 240 gaaagcagtt acccaacaga aacattctgg gctgggaacc agggaggcgc cctggtttgt 300 tttccccagt tgtaatagtg ccaagcaggc ctgattctcg cgattattct cgaatcacct 360 cctgtgttgt gctgggagca ggactgattg aattacggaa aatgcctgta aagtctgagt 420 aagaaacttc atgctggcct gtg 443 <212> Type: DNA <211> Length: 443       SequenceName: # 315       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcagagagc acagtgatca ccagcgtgag tggtggagga ggacacttgg attttttttt 60 ttgttttttt ttttttgctt aacagtttta gaatacattg tacttataca ccttattaat 120 gatcagctat atactattta tatacaagtg ataatacaga tttgtaacat tagttttaaa 180 aagggaaagt tttgttctgt atattttgtt accttttaca gaataaaaga attacatatg 240 aaaaaccctc taaaccatgg cacttgatgt gatgtggcag gagggcagtg gtggagctgg 300 acctgcctgc tgcagtcacg tgtaaacagg attattatta gtgttttatg catgtaatgg 360 actatgcaca cttttaattt tgtcagattc acacatgcca ctatgagctt tcagactcca 420 gctgtgaa 428 <212> Type: DNA <211> Length: 428       SequenceName: # 316       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgtccttat ctcatcaaag ccaggctgct ttattgcagg tgctgatatc aacatgttag 60 ccgcttgcaa gacccttcaa gaagtaacac agctatcaca agaagcacag agaatagttg 120 agaaacttga aaagtccaca aagcctattg tggctgccat caatggatcc tgcctgggag 180 gaggacttga ggttgccatt tcatgccaat acagaatagc aacaaaagac agaaaaacag 240 tattaggtac ccctgaagtt ttgctggggg ccttaccagg agcaggaggc acacaaaggc 300 tgcccaaaat ggtgggtgtg cctgctgctt tggacatgat gctgactggt agaagcattc 360 gtgcagacag ggcaaagaaa atgggactgg ttgaccaact nggtggaacc cctgggacca 420 ggactaaaac ctccagagga acggacaata gaatacctag aagaagttgc aattactttt 480 gccaaaggac tagctgataa gaagatctct ccaaagagag acaagggatt ggtggaaaaa 540 ttgacagcgt atgccatgac tattccattt gtcaggc 577 <212> Type: DNA <211> Length: 577       SequenceName: # 317       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccagctcca gtgctagtca gagtaaccac agctgtacat ccatgccatc ttctccagcc 60 accccagcca gtggaaccaa ggttatccca tcatcaggta gncaagttga aacgaccaac 120 accaactttt cattctagtc ggacatccct tgctggtgat accagcaata gttcttcccc 180 ggcctccaca ggtgccaaaa ctaatcgggc agaccctaaa aagtctgcca gtcgccctgg 240 gagtcgggct gggagtcgag ccgggagtcg agccagcagc cggcgaggaa gtgacgcttc 300 tgactttgac ctcttagaga cgcagtctgc ttgttccgac acttcagaaa gcagcgctgc 360 agggggccaa ggcaactcca ggagagggct aaacaaacct tccaaaatcc caaccatgtc 420 taagaagacc accactgcct cccccaggac tccaggtccc aagcgataac actgtcta 478 <212> Type: DNA <211> Length: 478       SequenceName: # 318       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttttctgtgg tcttactgat ctttgtatat tacatacatg ctttgaagtt tctggaaagt 60 agatcttttc ttgacctagt atatcagtga cagttgcagc ccttgtgatg tgattagtgt 120 ctcatgtgga accatggcat ggttattgat gagtttctta accctttcca gagtcctcct 180 ttgcctgatc ctccaacagc tgtcacagct tgtgttgagc aagcagtagc atttgcttcc 240 tcccaacaag cagctgggtt aggaaaacca tgggtaagga cggactcact tctcttttta 300 gttgaggcct tctagttacc acattactct gcctctgtat ataggtggtt ttctttaagt 360 ggggtgggaa ggggagcaca atttcccttc atactccttt taagcagtga gttatggtgg 420 tggtctcatg aagaaaagac cttttggccc aatctctgcc atatcagtga acctttagaa 480 actcaaaaac tgagaaattt actacagtag ttagaattat atcacttcac tgttctctac 540 t 541 <212> Type: DNA <211> Length: 541       SequenceName: # 319       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagaggatcc atgcttgctc tggccatggt tagtctggaa atggagaaac tcattcctga 60 ttggctttct cttacaattg aactgcttca gaaagcacag atggatagct cccagttgat 120 ccattgtcgg gagcttgtgg cacatcacct ttctactctg cagtcttccc tgcctctgaa 180 ttccgtttat gtctaccgtc ccctcaagca caccctggtg acctgtgaca aaggagtgtt 240 cagattacat ccctcctctg tcccaggccc agacttctcc aaggacaaca gcaagccaga 300 agtgccagtc agaggtacag cagcctttta ccatcatctc ccagctgcca gtgggtgcaa 360 gcagacctct actaaacgca aagtagagga aatggaagtg gatgacttct atgatggaat 420 caaacggctc tataatgaag ataatgtctc agaaaatgtg ggttctgtgt gtggcactga 480 tttatcaaga caagagggac atgcttcccc ttgtccacct ttgcagcctg tttctgtcat 540 gta 543 <212> Type: DNA <211> Length: 543       SequenceName: # 320       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccctcccct ccaatgataa agaaaatgat aaattttctg ttgtgcattc aattcttatt 60 ttaaataaga ctaagtatag gcattgtacc tgacattgct acgtttctac cagtgtttca 120 atttaaagtg ctagtgttta aaaacatttt caagggataa ggccttctgt actttgctta 180 tttgaagaat cagtggtagg agcagtgaag taaattctat ggagtacatt tctaaaatac 240 cacatttctg aaatcataaa taagtttatt caggttctaa ccctttgctg tacacaagca 300 gacagaaatg catctgttac ataaatgaga aaaagctatt atgctgatgg agcatgcttt 360 ttaaatcctt taaaaacact caccatataa acttgcattt gagcttgtgt gttcttttgt 420 taatgtgtag agttctcctt tctcgaaatt gccagtgtgt acttggctta actcaa 476 <212> Type: DNA <211> Length: 476       SequenceName: # 321       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tactttacaa tgttccctta agcaaaattg aatttgcttt gaacttttag ttatgcacag 60 actgataata aacctctaaa cctgcccagc ggaagtgtgt ttttttttaa atttaaatac 120 agaaacaact ggcaaaaatt gaactaagat ttactttttt ttccatagct gggatatagg 180 ctgcagctat agttgaacaa gcagtcttta aaaactgctg tgaaacacag gccatcaggg 240 aaaacgaaat gctgcactat taaattagag gtttttgaaa aatccaactc tcatcctggg 300 cagaggttgc ctagttggta tagaatgtta agtttcaaga aagtttacct ttgctttagg 360 tcataagttc cttatttgat tgctgtatat ggatacatgg ctgttcgtga cattctttat 420 gtgcaaattt gtgatttcaa aaatgtcctg ccagtttaag ggtacattgt agagccgaac 480 tttgagttac tgtgca 496 <212> Type: DNA <211> Length: 496       SequenceName: # 322       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtctctttgc tatatgacct tgaaaatctt ccggcatcca aggattccat tgtgcatcaa 60 gctggcatgt tgaagcgaaa ttgttttgcc tctgtctttg aaaaatactt ccaattccaa 120 gaagagggca aggaaggaga gaacagggca gttatccatt atagggatga tgagaccatg 180 tatgttgagt ctaaaaagga cagagtcaca gtagtcttca gcacagtgtt taaggatgac 240 gacgatgtgg tcattggaaa ggtgttcatg caggagttca aagaaggacg cagagccagc 300 cacacagccc cacaggtcct ctttagccac agggaacctc ctctggagct gaaagacaca 360 gacgccgctg tgggtgacaa cattggctac attacctttt gtgctgttcc cttcgtacac 420 caatgccagt gctcgagaca caccattaac cttgttccac acgttccggg actacctccc 480 ctaccacatt aagggccttt aaggcctata ttcacacacg tatg 524 <212> Type: DNA <211> Length: 524       SequenceName: # 323       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccattcccca gtggattcgg atgaaaactg gaaataaaat caggtacaac tccaaaagga 60 gacattggag aagaaccaag ctgggtctat aaggaattgc acatgagatg gcacacatat 120 ttatgctgtc tgaaggtcac gatcatgtta ccatatcaag ctgaaaatgt caccactatc 180 tggagatttc gacgtgtttt cctctctgaa tctgttatga acacgttggt tggctggatt 240 ca 242 <212> Type: DNA <211> Length: 242       SequenceName: # 324       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaacagtga gggttaggtc ttgggnaaaa ctataacttg ccaaagtaga agaaatagta 60 gtaccatatg ccaaagtgat agagatgaat catgtcagta gttagaataa catttcaact 120 gttttctttg ctaaaatcac agaaagaccc tattgacaac atctatgtct gtaaaaatgt 180 tagagtactt gtcatcttga atatagcctc cccaagagag aacagggtgg tattctaagt 240 atgtttcttt gtaacatctt tagcagtagg acagagccat acatgtgaaa tctgattttt 300 atgtgtgtta ttcgtttgtc tggttttact acctttgcaa aaacaaaata ccccaaagat 360 atttaaacaa ggttataatt tagcatcttc cctggatcta aatagta 407 <212> Type: DNA <211> Length: 407       SequenceName: # 325       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccttccggcg ggtgacattc agccggcggt tcggggcgac ggactctcca ttccagaacc 60 atggcccaat ttgtccgtaa ccttgtggag aagaccccgg cgctggtgaa cgctgctgtg 120 acttactcga agcctcgatt ggccacattt tggtactacg ccaaggttga gctggttcct 180 cccacccctg ctgagatccc tagagctatt cagagcctga aaaaaatagt caatagtgct 240 cagactggta gcttcaaaca gctcacagtt aaggaagctg tgctgaatgg tttggtggcc 300 actgaggtgt tgatgtggtt ttatgtcgga gagattatag gcaagcgggg catcattggc 360 tatgatgttt gaagaccaat ctttaacatc tgattatatt tgatttatta tttgagtgtt 420 gttggaccat gtgtgatcag actgctat 448 <212> Type: DNA <211> Length: 448       SequenceName: # 326       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaggaaggt ctagatttcc tgctcttaat aaaattacat tgaattgatt tttagaggta 60 atgaaaactt cctttctgag aagttagtgt taaggtcttg gaatgtgaac acattgtttg 120 tagtgctatc cattcctctc ctgagatttt aacttactac tggaaatcct taaccaatta 180 taatagcttt ttttctttat tttcaaaatg atttcctttg ctttgattag acactatgtg 240 cttttttttt ttaaccatag ttcatcgaaa tgcagctttt tctgaacttc aaagatagaa 300 tcccattttt aatgaactga agtagcaaaa tcatcttttt cattctttag gaaatagcta 360 ttgccaaagt gaaggtgtag ataataccta gtcttgttac ataaagggga tgtggtttgc 420 agaagaattt tctttataaa attgaagttt taagggacgt cagtgtttat gccatttttc 480 cagttccaaa atgattccat tccattctag aaatttgaag tatgtaacct gaaatcctta 540 ataa 544 <212> Type: DNA <211> Length: 544       SequenceName: # 327       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attgctgcat atcgtgccaa gggcaaaagt gaagcaggaa agaagggccc tggcaggcca 60 acaggctcaa agaagaagaa cgaaccagaa gatgaggagg aggaggagga agaagaagat 120 gaagatgagg aggaagagga tgaagatgaa gaataaatgg ctatccttta atgatgcgtg 180 tggaatgtgt gtgtgtgctc aggcaattat tttgctaaga atgtgaattc aagtgcagct 240 caatactagc ttcagtataa aaactgtaca gatttttgta tagctgataa gattctctgt 300 agagaaaata cttttaaaaa atgcaggttg tagctttttg atgggctact catacagtta 360 gattttacag cttctgatgt tgaatgttcc taaatattta atggtttttt taatttcttg 420 tgtatggtag cacagcaaac ttgtaggaat tagtatcaat agtaaatttt gggtttttta 480 ggatgttgca tttc 494 <212> Type: DNA <211> Length: 494       SequenceName: # 328       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctcccgctat ctccaaatcg gacgttcttt ctagctgaga tttttatttt tccacatctg 60 tagtgccatg aagcgattct gtctttgact tccaatggca aacctgggtg atcgggaaca 120 agcacgttgt acccttggct ggacatggcc aagacacaag gcattccacg gcggcaagct 180 gaccgcacag cagtctggct tgattttcag ccgtcatcat tgggttctgt tttgacagct 240 ctgctgtccc atagggactg cgactgggac caggtcaacc acgccagggg ggtgtcacca 300 gccttttctt tttttctttc tttttttttt tttcctcctt aagctgctgt caatccaaac 360 cattggcatc atcgtttctt ttcaattaaa accaacatat cagcaatagt ctgctctccc 420 c 421 <212> Type: DNA <211> Length: 421       SequenceName: # 329       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctcggactc tggttacctc tgaggctggg aaaggcctgg ctgcccactg cctccctccc 60 tgcccctcct tttatgtcca taaagtggcg tgaagtgaga cgttctcttt ggtggtcaac 120 ccggatgggt gacaggctgg atggccttgt gaacttgagc tcagtgtatg ctaggcaaca 180 attctcccgc tccagaccct caccgaccac ctgtcctggg accaggctgg gaggggagtg 240 tggcagggag gaggaagagg aaggtgagaa tgagtagaac agttttgtat tctactccct 300 acaagccatt ttgaacttct gccctcaccg gactctgggc tgtgactggg gcaccaaact 360 cagcacatga gtctccccta gctctcgtgg ggagagggat gctatttatt cagtttgggg 420 caggagggag aggagggaaa gtatttctaa ccctgatgcc aacagccggg 470 <212> Type: DNA <211> Length: 470       SequenceName: # 330       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgatcaccaa tgtacctcca gaggtaactg tgctcacgaa cagccctgtg gaactgagag 60 agcccaacgt cctcatctgt ttcatagaca agttcacccc a 101 <212> Type: DNA <211> Length: 101       SequenceName: # 331       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctccgggccg acatgagtgg ggaccacctc cacaacgatt cccagatcga agcggatttc 60 cgattgaatg attctcataa acacaaagat aaacacaaag atcgagaaca ccggcacaaa 120 gaacacaaga aggagaagga ccgggaaaag tccaagcata gcaacagtga acataaagat 180 tctgaaaaga aacacaaaga gaaggagaag accaaacaca aagatggaag ctcagaaaag 240 cataaagaca aacataaaga cagagacaag gaaaaacgaa aagaggaaaa ggttcgagcc 300 tctggggatg caaaaataaa gaaggagaag gaaaatggct tctctagtcc accacaaatt 360 aaagatgaac ctgaagatga tggctatttt gttcctccta aagaggatat aaagccatta 420 aagagacctc gaga 434 <212> Type: DNA <211> Length: 434       SequenceName: # 332       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtgcgcgtg gaattcatgg acgacacgag ccgatccatc atccgcaatg taaaaggccc 60 cgtgcgcgag ggcgacgtgc tcaccctttt ggagtcagag cgagaagccc ggaggttgcg 120 ctgagcttgg ctgctcgctg ggtcttggat gtcgggttcg accacttggc cgatgggaat 180 ggtctgtcac aatctgctcc ttttttttgt ccgccacacg taactgagat gctcctttaa 240 <212> Type: DNA <211> Length: 240       SequenceName: # 333       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggggaaat tgcttcactg tcttagaacc aagcaagatt cacctgtgtt ttgtgttcat 60 gttcatttgc ctcttaaagg caagggttga agataaataa ggtagcaatg tctatagttt 120 tggccttaac tatgccaatc taattataat tccctgtatt taaaatggtt tcttttactt 180 attgaaaggc attttagtgt ggtttatgtg taatattaaa gattattcaa cacctctcac 240 atcttacaga tctataaggt cacatgcttt taaaatagta gcaagttaaa cttcactctt 300 gaattcttta caatctaagt caaactaagt tataatttag gattgtcttt aaacagccat 360 tcagaaacaa aactgtagaa ctgtgtattt gattgggaat ggtgcttttg ccaacttaa 419 <212> Type: DNA <211> Length: 419       SequenceName: # 334       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtaactgc tctctgagtt ttgcacacga agttgccctc atctgctgga gatcgataag 60 gaaggcacaa gacgttctcc tctgcccgtg aggagcttcc cgcagccgcc tggcccagcc 120 tgggcacgtt ctccgaggca tgtgtctccc tgctcaccct cgtctgggca cctcagcatc 180 tgtggacttg agcgtccaaa aaccctgagt gtgattctgg gcagccggcc tggcttgaag 240 tccgccatga ccctgggcac aggggaagcc cagccgtggg cttaggagag agggaccagc 300 gcccagcgtt agggctggaa gacggcagtg ttcagaattc cagccgctca tctgaacaca 360 gaaggtgtga actgacctct aaagcagcgt gagatgggaa tgatctagaa aactttggat 420 ttttgaagta aattttaatg tttcatatta atttcttgaa aatgtattaa atgtcattga 480 aagccttatt acgcttttca gatcctttca at 512 <212> Type: DNA <211> Length: 512       SequenceName: # 335       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgtggattcc agtagtattt atattgagag aaacaaattt tagtccttct aactgtgcta 60 aaacttggat atttgtgaaa actccttacc accatacaag catcagaaga gctctcttgt 120 tgttagcact tattgtttgc aagaacagaa tacatccttt tatcctttta tgaaaaatga 180 caagtgaagg caaaagggga aggttatttg atctggaaga tgagtgttct gatgtggtgg 240 cttttgcaaa aatctttatt ggtgttgaaa actggaaaaa ataactcatc cagaattcat 300 attgtct 307 <212> Type: DNA <211> Length: 307       SequenceName: # 336       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtcaggctt ggctgcaaaa cactttattg atgtaggagc tggtgtcata gatgaagatt 60 atagaggaaa tgttggtgtt gtactgttta attttggcaa agaaaagttt gaagtcaaaa 120 aaggtgatcg aattgcacag ctcatttgcg aacggatttt ttatccagaa atagaagaag 180 ttcaagcctt ggatgacacc gaaaggggtt caggaggttt tggttccact ggaaagaatt 240 aaaatttatg ccaagaacag aaaacaagaa gtcatacctt tttcttaaaa aaaaaaaaaa 300 aagtttttgc ttcaagtgtt ttggtgtttt gcacttctgt aaacttacta gctttacctt 360 ctaaaagtac tgcatttttt actttttttt atgatcaagg aaaagatcat taaaaaaaaa 420 cacaaagaag tttttctttg tgtttggatc aaaaagaaac tttgtttttc cgcaattgaa 480 ggttgtatgt aaatctgctt tgtggtgacc tgatgtaaac agtgtcttct t 531 <212> Type: DNA <211> Length: 531       SequenceName: # 337       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaagtggtg gtgcatggac gactgaccac aatcaactgt gaggaaggag ataaactgaa 60 actcacctgc tttgaattgg caccgaaaag tgggaatacc ggggagttga gatctgtaat 120 tcatagtcac atcaaggtca tcaagaccag gaaaaacaag aaagacatac tcaatcctga 180 ttccaagtat ggaaacttca ccagactttt tcttctaaaa tctggatgtc attgacgata 240 atgtttatgg agataaggtc taagtgccta aaaaaatgta catatacctg gttgaaatac 300 aacactatac atacacacca ccatatatac tagctgttaa tcctatggaa tggggtattg 360 ggagtgcttt tttaattttt catagttttt ttttaataaa atggcatatt ttgcatctac 420 aacttct 427 <212> Type: DNA <211> Length: 427       SequenceName: # 338       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggaaagac gctctttagg ttttgttttg tttttttttt tttggttttg ttttttgttt 60 ttttttttac tctagggaaa acactgacga atggtcagag ctcctatcct gatcttttca 120 tcaaggcgcc tttcctaata atatggttca actgtgaatg tagaagtggg ggnnaggggg 180 gagaaaaaga aaactctggc gttagaggat ataaaaaaat ataagtacaa ttgttacaaa 240 taacgcagac ttcaaaaaca aaaaaatcac aacccaaaca aaccaaaatt taaatgatca 300 gaattggcag cacaaagaaa acgccctctc ctgacttgta ttgtggcagt ctgaacgccc 360 ccagaaaatt gtgccaaaga gtttagaaaa ataaatatac aataaaagta aacacataca 420 cacaaaacag caaacttcag gtaactattt tggattgcaa 460 <212> Type: DNA <211> Length: 460       SequenceName: # 339       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttcaggggcc gcatgtccat gaaggaggtg gatgagcaaa tgcttaatgt ccaaaacaaa 60 aacagcagct attttgttga gtggatcccc aacaatgtga aaacggctgt ctgtgacatc 120 ccacctcggg ggctaaaaat gtccgccacc ttcattggca acagcacggc catccaggag 180 ctgttcaagc gcatctccga gcagttcacg gccatgttcc ggcgcaaggc cttcctgcac 240 tggtacacgg gcgagggcat ggacgagatg gagttcaccg aggccgagag caacatgaat 300 gacctggtgt ccgagtacca gcagtaccag gatgccacag ccgaggagga gggcgagttc 360 gaggaggagg ctgaggagga ggtggcctag agccttcagt cactggggaa agcagggaag 420 cagtgtgaac tctttattca ctcccagcct gtcctgtggc ctgtcccact gtgtgcactt 480 gctgttttcc ctgtccacat ccatgctgta cagacaccac cat 523 <212> Type: DNA <211> Length: 523       SequenceName: # 340       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggggctgt tgaatttccc acataccctc cttccaccaa gttggaacat ccttggaaat 60 tggaagagca caagaggaga tccagggcaa ggccattggg atattctgaa acttgaatat 120 tttgttttgt gcagagataa agaccttttc catgcaccct catacacaga aaccaatttt 180 cttttttata ctcaatcatt tctagcgcat ggcctggtta gaggctggtt ttttctcttt 240 tcctttggtc cttcaaaggc ttgtagtttt ggntagtcct tgttctttgg aaatacacag 300 tgctgaccag acagcctccc cctgtcccct ctatgacctc gccctccaca aatgggaaaa 360 ccagactact tgggagcacc gcctgtgaaa taccaacctg aagacacngn ttcattcagg 420 caacgcacaa aacagaaaat gaaggtggaa caagcacaga tgttcttcaa ctgtttttgt 480 ctacactctt tct 493 <212> Type: DNA <211> Length: 493       SequenceName: # 341       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atctatctat tgtcagtcgt ctctcagttc ttgaggtata ttattttaat cattccatgc 60 cttaatatgc ttgcaataca agaatatctt cagatgggtg aataccaaaa ggctttcagt 120 ttttagtcag aaatcaagca ttgggctgtg gtagccaaaa accataggtt agctaaaaag 180 atcatgatac aattatttta ttaagtcatg gttaataaca aatgaatcca gacttgtcta 240 acagattttc catcaacaaa tattgttatg tgcaaaagta ttgcctatgt tgttttacac 300 accactgcat taactagaac tgctgagagg actgtatata tgattttaaa cctaagttga 360 ttttttttct cactcttgaa aggagtactt ctttgtgaaa gcagttctta cagctttgtt 420 ttcaaccagc taaaaatgtt ttatatatta ctctaacctg ttgtcctcca cattctattg 480 tcctaattgt actgttttc 499 <212> Type: DNA <211> Length: 499       SequenceName: # 342       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggggcagagt ccatgcaact tcaacatata gagaagcaac accagaaaat gatcctaact 60 actttatgaa tgaaccaaca ttttatacat ctgatggtgt tcctttcact gcagctgatc 120 cagattacca agagaaatac caagaattac ttgaaagaga ggactttttt ccagattatg 180 aagaaaatgg aacagattta tccggggctg gtgatccata cttggatgat attgatgatg 240 agatggaccc agagatagaa gaagcttatg aaaagttttg tttggaatca gagcgtaagc 300 gaaaacagta aagttaaatt tcagcatatc agttttataa agcagtttag gtatggtgat 360 ttagcagaac acaagagagc aagaaaatgt gtcacatcta taccaaattn aggatgttga 420 gttatgttac taatgtatgc aactttaatt ttgtttaaca ctatctgcca aaataaactt 480 tattccctat aacttaaaat gtgtatatat atataatagt ttattatgta cagttaattc 540 tactgttttg gctgcaa 557 <212> Type: DNA <211> Length: 557       SequenceName: # 343       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtcctctatg acttacccag aaggcaacgc ttctctttct ggtcaaaatg gctggtaagc 60 agggcgtttc agcatcaggc aagtggctgg atggtattcg aaaatggtat tacaatgctg 120 caggattcaa taaactgggg ttaatgcgag atgatacaat atacgaggat gaagatgtaa 180 aagaagccat aagaagactt cctgagaacc tttataatga caggatgttt cgcattaaga 240 gggcactgga cctgaacttg aagcatcaga tcttgcctaa agagcagtgg accaaatatg 300 aagaggaaaa tttctacctt gaaccgtatc tgaa 334 <212> Type: DNA <211> Length: 334       SequenceName: # 344       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttttaaattc gatcttcagc tgtactgtaa atagggtact gcattgtagt ctccatatct 60 gtattacttt tctgtaatat ttaagagttg cttaaaagca tacaaaatgt actgttacta 120 aaacagctaa ttatttctct ctcccccttt gacaggaagg ggcttcagtt gttcctccat 180 ggctagaacc ataataaaca atgtacccgt aatttgtaac ataaagtatt gcaatatgtt 240 agtaacaatc ttgcagcctt cctttccaaa gttcatttta ttttgatcag ttcagtatat 300 tgcactaatt attttaggta ttttcattat atgaaagcta ccatgtgtca gagatgattt 360 aatctattta agtgttggac tgctaggaga acttgtacat ttatgataat gcagaattag 420 gaaaacggtt caccagtgtt tagttttata ttgaggtgct caggttggaa taaagtg 477 <212> Type: DNA <211> Length: 477       SequenceName: # 345       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cggctgcaca ccagctctaa gagcgagagt gaacgagaga gggagggaga gagtgagagc 60 gagcgagatc tttggagaga tttttttttt tngcctccta cttctgtctt gaagccagac 120 aatcgacttc agctctccct cccctccctc tttctccacg ttctgctccc actcgctctc 180 ctgtcccctt cccctcccct cccggcggaa agccccccga aaccaacaaa gctgagccga 240 gagaaacaaa caaaacaaac acaccgggcc agacaagcca tcgacaaaac tttgca 296 <212> Type: DNA <211> Length: 296       SequenceName: # 346       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaagaaacca tgacaaacct agcttttaaa aaatatttta agaaagagaa tgaactgtgg 60 aatttattgg cagccaagga atgtgtccaa gacacatgct gaggttttga ataaaaagtg 120 aacttttgta atttgaattg ggtcccgctt agttcttgaa ttgttatgaa aatcctatat 180 ctgtttgtat atttgcaaac cctttgtatt ataattgttg atattttccc tttttaaaaa 240 ataccattga aatcagcatg acaaaaataa cactgttggc acttataggt aacgtgattg 300 attcagtatc ttagagttta cagtttgtgt tttaaaaaaa ctgaaggttt tttttttaag 360 tgcaacattt ctgtatactg taaaagttat aataactgaa ctgtttggtc gagtctttgt 420 gtgttatatt ccaag 435 <212> Type: DNA <211> Length: 435       SequenceName: # 347       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtctcaga atgctcagga ccaaggtgca gagatggaca agagcagcca ggagacccag 60 cgatctgagc ataaaactca ttaaacctgc ccctatcact agtgcatgct gtggccagac 120 agatgacacc ttttgttatg ttgaaattaa cttgctaggc aaccctaaat tgggaagcaa 180 gtagctagta taaaggccct caattgtagt tgtttccagc tgaattaaga gctttaaagt 240 ttctggcatt agcagatgat ttctgttcac ctggtaagaa aagaatgata ggcttgtcag 300 agcctatagc cagaactcag aaaaaattca aatgcactta tgttctcatt ctatggccat 360 tgtgttgcct ctgttactgt ttgtattgaa taaaaacatc ttcatgtggg ctggggtaga 420 aactggtgtc tgctctggtg tgatctgaaa aggcgtcttc actgctttat ctcatgatgc 480 ttgcttgt 488 <212> Type: DNA <211> Length: 488       SequenceName: # 348       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tctctgggct ccaggctgag gacgaggctg attattactg ctgctcatat gcaggtagtt 60 acactgtggt tttcggcgga gggaccaaac tgaccgtcct aggtcagccc aaggctgccc 120 cctcggtcac tctgttcccg ccctcctctg aggagcttca agccaacaag gccacactgg 180 tgtgtctcat aagtgacttc tacccgggag ccgtgacagt ggcctggaag gcagatagca 240 gccccgtcaa ggcgggagtg gagaccacca caccctccaa acaaagcaac aacaagtacg 300 cggccagcag ctatctgagc ctgacgcctg agcagtggaa gtcccacaga agctacagct 360 gccaggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctaca gaatgtt 417 <212> Type: DNA <211> Length: 417       SequenceName: # 349       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttattcttct aattaacagc tcctaggaaa atgtagactt ttgctttatg atattctatc 60 tgtagtatga ggcatggaat agttttgtat cgggaatttc tcagagctga gtaaaatgaa 120 ggaaaagcat gttatgtgtt tttaaggaaa atgtgcacac atatacatgt aggagtgttt 180 atctttctct tacaatctgt tttagacatc tttgcttatg aaacctgtac atatgtgtgt 240 gtgggtatgt gtttatttcc agtgagggct gcaggcttcc tagaggtgtg ctataccatg 300 cgtctgtcgt tgtgcttttt tctgttttta gaccaatttt ttacagttct ttggtaagca 360 ttgtcgtatc tggtgatgga ttaacatata gcctttgttt tct 403 <212> Type: DNA <211> Length: 403       SequenceName: # 350       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatagtcgga atagagccgc cccaactcag atcctacaac acgcaagttc cttcttgaac 60 cctggtgcct cctaccctat ggccctgaat ggtgcactgg tttaattgtg ttggtgtcgg 120 cccctcacaa atgcagccaa gtcatgtaat tagtcatctg gaacaaagac taaaaacagc 180 agagaattgc gggttctacc cagtcagaag atcacaccat ggagactttc tactagagga 240 cttgaaagag aactgagggg ccacaaaata aacttcacct tccattaagt gttcaagcat 300 gtctgcaaat taggagggag ttagaaacag tctttttcat cctttgtgat gaagcctgaa 360 attgtgccgt gttgccttat atgaatatg 389 <212> Type: DNA <211> Length: 389       SequenceName: # 351       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgtctccccg ctatctaaaa aagtataaga acaagcagat aacagcgaga atcttggagg 60 cccatcagaa tgtagctcag atgagtctaa ttgaagccaa gatgagattt attcaagctt 120 ggcagtcact acctgaattt ggcatcactc acttcattgc aaggttccaa gggggcaaaa 180 aagaagaact tattggaatt gcatacaaca gactgattcg gatggatgcc agcactggag 240 atgcaattaa aacatggcgt ttcagcaaca tgaaacagtg gaatgtcaac tgggaaatca 300 aaatggtcac cgtagagttt gcagatgaag tacgattgtc cttcatttgt actgaagtag 360 attgcaaagt ggttcatgaa ttcattggtg gctacatatt tctctcaaca cgtgcaaaag 420 accaaaacga gagtttagat gaagagatgt tctacaaact taccagtggt tgggtgtgaa 480 tagaaatact gtttaatgaa actccacggc cataa 515 <212> Type: DNA <211> Length: 515       SequenceName: # 352       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaaatgctat tagtccgtcg tgcttnattt gtttttgtcc ttgaataagc atgttatgta 60 tatngtctcg tgtttttatt tttacaccat attgtattac acttttagta ttcaccagca 120 taancactgt ctgcctaaaa tatgcaactc tttgcattac aatatgaagt aaagttctat 180 gaagtatgca ttttgtgtaa ctaatgtaaa aacacaaatt ttataaaatt gtacagtttt 240 ttaaaaacta ctcacaacta gcagatggct taaatgtagc aatctctgcg ttaattaaat 300 gcctttaaga gatataatta acgtgcagtt ttaatatcta ctaaattaag aatgacttca 360 ttatgatcat gatttgccac aatgtcctta actctaatgc ctggactggc catgttctag 420 tctgttgcgc tgttacaatc tgtattggtg ctagtcagaa aattcctagc tcacatagcc 480 caaaagggtg cgagggagag gtggattacc agtattgttc aataatccat ggttca 536 <212> Type: DNA <211> Length: 536       SequenceName: # 353       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatgcctaac caaggactag agctccttct tgagatctaa atctaaagta aatgtgcatt 60 aaagcagtgt gcttcaaagg catcagacga tgaaagcaac ataccacaac taggagttat 120 ttctcaaact taaatgtcct ctgggaatcc agacttaaaa ataagagcaa acttaacaca 180 ctatccattt tcgagcaaac ttaacccact atatccattt tgctcatgtg ttttatgcaa 240 ccagctttcc atcaaatcct caatccttga atccaggtaa aaggttaatt atcctaggat 300 tagtgaatga ttcaatgaag ctttcttgaa aacaaacata ggagtgtaat gtactattat 360 gtttgtatcc tgttttagtt tataaagcac tttcacatac attatgg 407 <212> Type: DNA <211> Length: 407       SequenceName: # 354       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acccaactac tctggtacca ttgctttggc cctgttagtg tcgcttgttg gaggtttgct 60 ttatttgaga aggaacaact tggagttcat ctataacaag actggttggg ccatggtgtc 120 tctgtgtata gtctttgcta tgacttctgg ccagatgtgg aaccatatcc gtggacctcc 180 atatgctcat aagaacccac acaatggaca agtgagctac attcatggga gcagccaggc 240 tcagtttgtg gcagaatcac acattattct ggtactgaat gccgctatca ccatggggat 300 ggttcttcta aatgaagcag caacttcgaa aggcgatgtt ggaaaaagac ggataatttg 360 cctagtggga ttgggcctgg tggtcttctt cttcagtttt ctactttcaa tatttcgttc 420 caagtaccac ggctatcctt atagtgatct ggactttgag tgagaagatg tgatttggac 480 catggcactt aaaaactcta taacctcagc cttttaat 518 <212> Type: DNA <211> Length: 518       SequenceName: # 355       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actgggctac tctggcgcag aaattaggtc tggggatact taataatgcc ttccggctga 60 gtcctgctcc ttccaaaaca cttatggaca actatgaggt ctctgggggt acagtcagag 120 agctggtgga ggccctgaga caaatgggct acaccgaagc aattgaagtg atccaggcag 180 cctccagccc agtgaagacc acctctcagg cccactcgct gcctctctcg cctgcctcca 240 caaggcagca aatagacgag ctccgagaca gtgacagtgt ctgcgacacg ggcgtggaga 300 catccttccg caaactcagc tttaccgagt ctctgaccag tggtgcctca ctgctaactc 360 tcaacaaaat gccccatgat tatgggcagg aaggacctct agaaggcaaa atttagcctg 420 ctgacaattt cccacaccgt gtaaaccaaa gccctaaaat tcactgcgtt gtcc 474 <212> Type: DNA <211> Length: 474       SequenceName: # 356       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtagatccct tcagttcaaa acataatgtg attgtgggca gaaatggatc tggaaaaagt 60 aacttttttt atgcaattca gtttgttctc agtgatgagt ttagtcatct tcgtccagaa 120 cagcggttgg ctttattgca tgaaggtact ggtcctcgtg ttatttctgc ttttgtggag 180 attatttttg ataattcaga caaccggtta ccaatcgata aagaggaagt ttcacttcga 240 agagttattg gtgccaaaaa ggatcagtat ttcttagaca agaagatggt cacgaaaaat 300 gatgtgatga acctccttga aagcgctggt ttttctcgaa gcaatcctta ttatattgtt 360 aaacaaggaa agatcaacca gatggcaaca gcaccagatt ctcagagat 409 <212> Type: DNA <211> Length: 409       SequenceName: # 357       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaggatatc gaacgccaag ttagagaatt gaaaacaaaa atttcagcta tgaaagaaga 60 aaaagaacag cttagtgctg aaagacaaga gcagattaag cagaggacta agttggagct 120 taaagccaag gatttacaag atgaactagc aggcaatagt gaacaaagga aacgtttatt 180 aaaagagagg cagaagctgc ttgaaaaaat agaagaaaag cagaaagaac tggcagaaac 240 agaacccaaa ttcaacagtg tgaaagagaa agaagaacga ggaattgcta gattggctca 300 agctacccag gaaagaacgg atctttatgc aaagcagggt cgaggaagcc agtttacatc 360 aaaagaagaa agggataagt ggattaaaaa ggaactcaag tctttagatc aggctattaa 420 tgacaagaaa agacagattg ctgctataca taaggatt 458 <212> Type: DNA <211> Length: 458       SequenceName: # 358       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaccggttgg gtcagagttc catgctgggt gagcagggtg cccggatcca gagtgtgaag 60 acagaggcag aggagctgtt tggggagacc atggagatga tggacaggat gaaagacatg 120 gagttggagc tgctgcgggg cagccaggcc atcatgctgc gctcagcgga cctgacagga 180 ctggagaagc gtgtggagca gatccgtgac cacatcaatg ggcgcgtgct ctactatgcc 240 acctgcaagt gatgctacac gttccagccc gttgccccac tcatctgcgc gctttgcttt 300 tggttggggg gcagattggg ttggaatgct ttccatctcc aggagacttt catgtagccc 360 aaagtacagc ctggaccacc cctggtgtgt gtagctagta agattaccct gagctgcagc 420 tg 422 <212> Type: DNA <211> Length: 422       SequenceName: # 359       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggacatca atgaccagat ccagaacgcc gccttcatgt acccggccag cccctggagc 60 cacatctcag ctggagccat tgacctcatc aacaacctgc tgcaggtgaa gatgcgcaaa 120 cgctacagcg tggacaaatc tctcagccac ccctggttac aggagtacca gacgtggctg 180 gacctccgag agctggaggg gaagatggga gagcgataca tcacgcatga gagtgacgac 240 gcgcgctggg agcagtttgc agcagagcat ccgctgcctg ggtctgggct gcccacggac 300 agggatctcg gtggggcctg tccaccacag gaccacgaca tgcaggggct ggcggagcgc 360 atcagtgttc tctgaggtcc tgtgccctcg tccagctgct gccctccaca gcggttcttc 420 acaggatccc agcaatgaac tgttctaggg aaagtggctt cctgcccaaa ctggatggga 480 cacgtgggga gtggggtggg gggagctatt tccaaggccc ctccctgttt ccccagcaat 540 taaaacggac tcatctctgg ccc 563 <212> Type: DNA <211> Length: 563       SequenceName: # 360       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgaacgaatt tattttcccc tcagtttttg agggcattaa aaaggcatta aatcaagaca 60 aatcatgtgc ttgagaaaaa taaaattaat gaaaacacag cacttatgtt ggtttagctg 120 cagcctcctt ggaggtagaa tttatttatt taaaattact ggttgcatca agaacccata 180 gggtgtacaa aaggttctat aaaatctgca ttatagagac aaagaggcag gcaaatccat 240 gtcacaaggg taaagcttac agtttacaaa ctgggaacgc cagggtgtag gatataaaaa 300 cgcactcttg agaaaacaaa tgtaatcagg gtgctgaaaa cttgcatggt gctttcagac 360 attagccttg ttcaacaaat ttcttgtatt gacagatcca tagtgtgcat gggcagacac 420 attttgcctc tatgtctctt aaaattttaa ttaaaaatac tctttccagt aatcctaatt 480 tgcacgaaga tataatgtcc acatt 505 <212> Type: DNA <211> Length: 505       SequenceName: # 361       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcttcctga cgacatgaaa taattggggg ttttgttgtt tagttacatt aggctttgct 60 atatccccag gccaaatagc atgtgacaca ggacagccat agtatagtgt gtcactcgtg 120 gttggtgtcc tttcatgctt ctgccctgtc aaaggtccct atttgaaatg tg 172 <212> Type: DNA <211> Length: 172       SequenceName: # 362       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcagacgtt gtggcggaga agggcagtgg ctgtagctgc cctttccgtt tccagggttc 60 cgaccaggtc gttgaggact tcctcatgga gattggcaca ggaccagact caagacacac 120 aactcataac agttgatgaa aaattggata tcactacttt aactggcgtt ccagaagagc 180 atataaaaac tagaaaagtc aggatctttg ttcctgctcg caataacatg cagtctggag 240 taaacaacac aaagaaatgg aagatggagt ttgataccag ggagcgatgg gaaaatcctt 300 tgatgggttg ggcatcaacg gctgatccct tatccaacat ggttctaacc ttcagtacta 360 aagaagatgc agtttccttt gcagaaaaaa atggatggag ctatgacatt gaagagagga 420 aggttccaaa acccaagtcc aagtcttatg gtgcaaactt ttcttggaac aaaagaacaa 480 gagtatccac aaaataggtt ggcactgact atatctctgc ttgactg 527 <212> Type: DNA <211> Length: 527       SequenceName: # 363       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcggaaatac ctgaaataca gcaaaaatat cctggaccgg caagatcctc cctctgtggt 60 ggtcaccagc caccaggccc caggagaaaa gaagaaactg aagtgcctgg cctacgactt 120 ctacccaggg aaaattgatg tgcactggac tcgggccggc gaggtgcagg agcctgagtt 180 acggggagat gttcttcaca atggaaatgg cacttaccag tcctgggtgg tggtggcagt 240 gcccccgcag gacacagccc cctactcctg ccacgtgcag cacagcagcc tggcccagcc 300 cctcgtggtg ccctgggagg ccagctagga agcaagggtt ggaggcaatg tgggatctca 360 gacccagtag ctgcccttcc tgcctgatgt gggagctgaa ccacagaaat cacagtcaat 420 ggatccacaa ggcctgagga gcagtgtggg gggacagaca ggaggtggat ttggagaccg 480 aagactggga tgcctgtctt gagtagactt ggacccaaaa aatcatctca ccttgagccc 540 a 541 <212> Type: DNA <211> Length: 541       SequenceName: # 364       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggagagagtc gttcgacctg ctgctgagca gntaaaaatg gagtggctgc cttccacgct 60 ttcctgaaga cagagttcag tgaggagaac ctggagttct ggctggcctg tgaggagttc 120 aagaagatcc gatcagctac caagctggcc tccagggcac accagatctt tgaggagttc 180 atttgcagtg aggcccctaa agaggtcaac attgaccatg agacccgcga gctgacgagg 240 atgaacctgc agactgccac agccacatgc tttgatgcgg ctcaggggaa gacacgtacc 300 ctgatggaga aggactccta cccacgcttc ctgaagtcgc ctgcttaccg ggacctggct 360 gcccaagcct cagccgcctc tgccactctg tccagctgca gcctggacga gccctcacac 420 acctgagtct ccacggcagt gaggaagcca gccgggaaga gaggttgagt cacccatccc 480 <212> Type: DNA <211> Length: 480       SequenceName: # 365       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaaataagt ctcttggcgg tccctgagag tcctgctgaa atccagccag tgttttttgt 60 ggtatgagaa caggcaaaaa gagatgcccc gagatagaag gggagccttg tgtttctttc 120 ctgcagacgt gagatgaaca ctggagtggg cagaggtggc ccaggaccat ggcaccctta 180 gagtgcagaa gctgggggga gaggctgctt cgaagggcag gactggggat aatcagaacc 240 tgcctgtcac ctcagggcat cactgaacaa acatttcctg atgggaactc ctgcggcaga 300 gcccaggctg gggaagtgaa ctacccaggg cagccccttt gtggcccagg ataatcaaca 360 ctgttctctc tgtaccatga gctcctccag gagattattt aagtgtattg tatcattggt 420 tttctgtgat tgtcataaca ttgtttttgt tattgttggt gctgttgtta tttattattg 480 taatttcagt ttgcctctac tggagaatct cagcaggggt ttcagcctga ctgtc 535 <212> Type: DNA <211> Length: 535       SequenceName: # 366       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatcatcaat tctttctcat tctccattta tctgaaggtt cttttgccct tattaacctc 60 tcaactttta ttgctgtatt ctagtcagac cagaacatac ttccactaca tcagttactt 120 ggcatcattt cacctcagtt tattattgcc aaataataat ttgtgtcagc attttcaact 180 atggttattc atccaaccct tggatctctt tgagtctact gataatctcc actggaaagg 240 tggaattgaa atgtggtcca cattttaact agctatttcc tggggctgta tttttcagaa 300 tatgctgagc tacatttgct gcaatctg 328 <212> Type: DNA <211> Length: 328       SequenceName: # 367       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagacttac tgttggccat agttaattgt gtgaggaaca cgccggcctt tttagccgaa 60 agactgcatc gagccttgaa gggtattgga actgatgagt ttactctgaa ccgaataatg 120 gtgtccagat cagaaattga ccttttggac attcgaacag agttcaagaa gcattatggc 180 tattccctat attcagcaat taaatcggat acttctggag actatgaaat cacactctta 240 aaaatctgtg gtggagatga ctgaaccaag aagataatct ccaaaggtcc acgatgggct 300 tttccaacag ctccacctta cttcttctca tactatttaa gagaacaagc aaatataaac 360 agcaacttgt gttcctaaca gg 382 <212> Type: DNA <211> Length: 382       SequenceName: # 368       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtggagccgg gaataactgg gccaagggcc actacacaga gggagccgag ctggtcgact 60 cggtcctgga tgtggtgagg aaggagtcag agagctgtga ctgtctccag ggcttccagc 120 tgacccactc tctggggggc ggcacggggt ccgggatggg caccctgctc atcagcaaga 180 tccgggaaga gtacccagac cgcatcatga acaccttcag cgtcatgccc tcacccaagg 240 tgtcagacac ggtggtggag ccctacaacg ccaccctctc ngtccaccag ctggtggaaa 300 acacagatga aacctactnc attganaacg aggccctgta tgacatctgc ttccgcaccc 360 tgaagctgac cacccccacc tacggggacc tcaaccacct ggtgtcggcc accatgagcg 420 gggtcacnnc acctgcctgc gcttcccggg ccagctgaac gcagacctgc gcaa 474 <212> Type: DNA <211> Length: 474       SequenceName: # 369       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtatctct tgggacaact tttaaaagct atttttacca agtattttgt aaatgctaat 60 tttttaggac tctactagtt ggcatacgaa aatatataag gatggacatt ttatcgtctc 120 atagtcatgc tttttggaaa tttacatcat cctcaagtaa aataaatatc agttaaatat 180 tggaagctgt gtgtaagatt gattcagcat tccatgcact tgctttaaaa tttagtcctg 240 tgcatactgt ggtgttttta ctgtgcatat ttgaattttt catgcagttt ttctagagca 300 ataatcagtg gtgcttttgt acctaggttt tatgtgattt taatgaaaca tggatagttg 360 tggccacctg ctg 373 <212> Type: DNA <211> Length: 373       SequenceName: # 370       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgcccagga gcatgaactg atccatgaat gccttttcca ggttaaaatt tggtcactga 60 tgcctataat cgtggaagtc agagggattc ccctttttca tctcatttta ataggaaaat 120 tccttatggt taacatctcc ctacaaactc ctactacgtc gtctaaattg ctgctctgga 180 ataaggtgat ttctgccccc agattcttcc ctagccggta gatacgtgaa gatattccca 240 actgtggaat ggcagtgtag gtagcttcag gaa 273 <212> Type: DNA <211> Length: 273       SequenceName: # 371       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agtgatgagt tgtgtgcttg tccctggcag tggcaggctg tgtcctatgg acatcttggc 60 aggacatgga atttggcctc atgacaggcc caactaggga taggaaggaa aatgaagaga 120 gccagtattt ccccttctcc agaagcaggt actcagcttt ctgggaaaag cgtgcctcca 180 gccgtgggga caggccatcc tactgactac ctcttgcttg gcatgaaata aactgctatc 240 ctccccttgg aatctaccgc cactctacat cctactgctt tggcctccct ctcctctcac 300 cagatggcat gtggtgtggc acctgtggct ggacacagga ggcctcagga tcacaaatgt 360 tacactagac atatgtccta atgtgctgcc cagaaacctc aactgttccc cagctactga 420 ggggcactgt cagcgagatg ttgggtctgg aggtgatgag atcgggccac acttgagctg 480 agtcaccaga ccctattgct tcaacagtgc ttggcccccg ccagcttgtc ccagccactc 540 tagctgctgg atgtgatcct gggacatgta ctccaagcc 579 <212> Type: DNA <211> Length: 579       SequenceName: # 372       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggctggat ggacttgctc aagttcacca gcatggtagt ggcaaagaga ggtccagagt 60 cctggccctt gatgccgagc tcatgccaca aagctcagta ggagggatgt tccagtggat 120 gagggccagc caggaagcac aggtccaagg ctggtcccac acttatcagc agcaacaact 180 gtcagttcat cctgcatggg aaaaatgttg gaatgggagt ctgaaatggg gctactgttt 240 cagtcctaac gtgctgtgtg acattgggac aacactttcc ctctctggac ctcagtttcc 300 ctctgtatac aaggatcaga ttcttgctgt gacccaagaa ctcctgaaat catatagaaa 360 ggctggggtg ggccctgtca ttcgtggttg atttcaatac actcaagtgc cattcatcct 420 t 421 <212> Type: DNA <211> Length: 421       SequenceName: # 373       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taacaccact ggctacaatg atcgtgctgt attggagaga gaagtccaat acactctgga 60 aatgattaaa ctagtaccac ataatgaaag tgcatggaac tatttgaaag ggattttgca 120 ggatcgtggt ctttccaaat atcctaatct gttaaatcaa ttacttgatt tacaaccaag 180 tcatagttcc ccctacctaa ttgcctttct tgtggatatc tatgaagaca tgctagaaaa 240 tcagtgtgac aataaggaag acattcttaa taaagcatta gagttatgtg aaatcctagc 300 taaagaaaag gacactataa gaaaggaata ttggagatac attggaagat cccttcaaag 360 caaacacagc acagaaaatg actcaccaac aaatgtacag caataacacc atccagaaga 420 acttgatgga atgcttttat tttttattaa gggaccctgc aggagtttca cacgagagtt 480 ccttcccttt tgtggtgtaa aagtgcatca cacaggtatt gctttt 526 <212> Type: DNA <211> Length: 526       SequenceName: # 374       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcttccggtg cggaggtcag ggacaagatg gtgccaccgg tgcaggtctc tccgctcatc 60 aagctcggcc gctactccgc cctgttcctc ggtgtggcct acggagccac gcgctacaat 120 tacctaaaac ctcgggcaga agaggagagg aggatagcag cagaagagaa gaagaagcag 180 gatgaactga aacggattgc cagagaattg gcagaagatg acagcatatt aaagtgagtg 240 accctgcgac ccactctttg gaccagcagc ggatgaataa agcttcctgt gttgtgtgac 300 <212> Type: DNA <211> Length: 300       SequenceName: # 375       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: catggagctc cgaattcttg cgtgtgtgta gatgaggggc gggggacggg cgccaggcat 60 tgttcagacc tggtcggggc ccactggaag catccagaac agcaccacca tctagcggcc 120 gctcgaggga agcacccgcc ggttggccga agtccacgaa gccgccctct gctagggaaa 180 acccctggtt ctccatgcca cacctctctc caggtgccct ctgcctcttc accccacaag 240 aagccttatc ctacgtcctt ctctccatct atcggacccc agtttccatc actatctcca 300 gagatgtagc tattatgcgc ccgtctacag ggggtgcccg acgatgacgg tgccttcgca 360 gtcaaattac tcttcgggtc ccaaggtttg gctttcacgc gctccattgc cccggcgtgg 420 caggccattc caagcccttc cgggctggaa ctggtgtcgg aggagcctcg ggtgtatcgt 480 acgccctggt gttggtgttg cctcactcct ctgagctctt ctttctgatc aagcc 535 <212> Type: DNA <211> Length: 535       SequenceName: # 376       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagccgcagt cttggaccat aatcatggtg gacatgatgg acttgcccag gtcgcgcatc 60 aacgccggca tgctagctca attcatcgac aagcctgtct gcttcgtagg gaggctggaa 120 aagattcatc ccaccggaaa aatgtttatt ctttcagatg gagaaggaaa aaatggaacc 180 atcgagttga tggaacccct tgatgaagaa atctctggaa ttgtggaagt ggttggaaga 240 gtaaccgcca aggccaccat cttgtgtaca tcttatgtcc agtttaaaga agatagccat 300 ccttttgatc ttggacttta caatgaagct gtgaaaatta tccatgactt ccctcagt 358 <212> Type: DNA <211> Length: 358       SequenceName: # 377       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagaactatc tcgtgacttt accagattgt ttgtttggga aattttgcac tctacaattc 60 gtaagatgaa caaacatgtc ctgaagatcc agaaagagct ggaagaagct aaagagaaac 120 ttgctaggca acacaaacgg cgaagtgatg atgacgacag aagcagtgac aggaaagacg 180 gggttcttga ggaacaaata gaacgacttc aggaaaaagt ggaatctgct cagagtgaac 240 aaaagaatct tttcctcgtt atatttcagc ggtttatcat gatcttgacc gagcacctag 300 tacgatgcga aactgatggg accagtgtat taacaccatg gtataagaac tgtatagaga 360 ggctgcagca gatcttccta cagcatcacc aaataatcca gcagtacatg gtgaccctgg 420 agaaccttct cttcactgct gaattagacc ctcatatctt ggccgtgttc cagcagttct 480 gtgccctgca ggcctaaggg tcattttttc ctcatgtcaa gg 522 <212> Type: DNA <211> Length: 522       SequenceName: # 378       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtatcgtctt cctcaacaag tgcgagacct gggtgtccaa cctgcgctac aaccacatgc 60 tgcggaagaa gaacctgctg cttcagtaca acagcgggga ggacctggcc gtcaacatca 120 tcttccccga gaagatcgac atgaccacct tcagcaagga ggccggcgac gaggagatct 180 aagcagcgtt cccacagccc cctctagatt cttggagttc cgcagagctt actatacgcg 240 gtctgtccta atctttgtgg tgttcgctat ctcttgtgtc aaatctggtg aacgctacgc 300 ttacatatat tgtctttgtg ctgctgtgtg acaaacgcaa tgcaaaaaca atcctctttc 360 tctct 365 <212> Type: DNA <211> Length: 365       SequenceName: # 379       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatctcagtt ggaccatcct taacttgatt gaactgtcta ggaactttac agattgttct 60 gcagttctct cttcttttcc tcaggtagga cagctctagc attttcttaa tcaggaatat 120 tgtggtaagc tgggagtatc actctggaag aaagtaacat ctccagatga gaatttgaaa 180 caagaaacag agtgttgtaa aaggacacct tcactgaagc aagtcggaaa gtacaatgaa 240 aataaatatt tttggtattt atttatgaaa tatttgaaca ttttttcaat aattcctttt 300 tacttctagg aagtctcaaa agaccatctt aaattattat atgtttggac aattagcaac 360 aagtcagata gttagaatcg aagtttttca aatccattgc ttagctaact ttttcattct 420 gtcacttggc ttcgattttt atattttcct attatatgaa atgtatcttt tggttgtttg 480 atttttcttt ctttctttgt aaatagttct gagttctgtc aaatgccgtg 530 <212> Type: DNA <211> Length: 530       SequenceName: # 380       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actcttgccc aaaactatac actgtatttc tgttatagta acaaaataga gttatgtaga 60 attgtatgga actcaaattt aaaccatgct ttcttgtagt actgattgaa acttacacgt 120 tttattctac tcatagtgag cttattctta ttttggattg attttccaaa accacagctt 180 cagcagcaac aatcagaatg tccaaatgct gtcctttccc ttacagagaa gaacaatggt 240 aactaaaagc tgcatataac tagcaataac tacattgaac ggtgtgcatt gttcatgatt 300 gttgtgtttt aagacttgta tataaactgc tttttccaaa ctctgtataa cttttaaatg 360 gctggaacta ctcgtataag gactagactg tatttttgac atgctcctat ttttgtaact 420 tgaa 424 <212> Type: DNA <211> Length: 424       SequenceName: # 381       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagatcccca tgaagaaata ctcaaggcat ttaaactatt tgatgatgat gattcaggta 60 aaataagctt gaggaatttg cgacgtgttg ctagagaatt gggtgaaaac atgagtgatg 120 aagaacttcg agctatgata gaagaatttg acaaagatgg tgatggagaa ataaaccaag 180 aggagttcat tgctattatg actggtgaca tttaaagaat tacaaggata aacactaaga 240 atgttgcagt taccatctta tattctattt ttgtgcctgg agccatgtga aaaaaaccaa 300 cttagttctt ttatcctaaa ggaccaaaaa taagcatctt atatatctgt attttactac 360 tgttaagttt ctttgtatga actgtgttgt tagtactcag atagtttagc tttgtattta 420 taatagagct tttatataaa gttttaaaaa ttgaatgtgt gatatgtgtt ctttgaaggt 480 tttttaattt aacatttata gtcacttttt agtgcacaca tt 522 <212> Type: DNA <211> Length: 522       SequenceName: # 382       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaggagctta ttcctggctc catcgctaac acgttgactg cttattatgg gaaagttttc 60 tctgaagcca gggagaagca ttgattgatg tgggcaaatc caagctccag ccaggtcgca 120 gtcccaaatg ccgacatcac tgactccagg gaccagggac atggagaaag ctgtttatga 180 tatctttaac caggccctct tactagagct ggtgtttgtg actggccaac aagatgtggc 240 tatgccaggg gacatctgag tatgtgccca gtcatctttt ttcacaggtt gaagggagag 300 aaaagatttt gagttaaggt cattggctgc tctactctgt cccctacctg gtcacctagt 360 gatagcccca gtggagatac tgtccataca aggtcttccc agaggctgga taccacagta 420 aaaggccagg ccaggagggg taggagacta tggagatctt acctcctgat aaatgtg 477 <212> Type: DNA <211> Length: 477       SequenceName: # 383       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagagctcgc tttgagtgac tgggttttgt gattgcctct gaagcctatg tatgccatgg 60 aggcactaac aaactctgag gtttccgaaa tcagaagcga aaaaatcagt gaataaacca 120 tcatcttgcc actaccccct cctgaagcca cagcagggtt tcaggttcca atcagaactg 180 ttggcaaggt gacatttcca tgcataaatg cgatccacag aaggtcctgg tggtatttgt 240 aactttttgc aaggcatttt tttatatata tttttgtgca catttttttt tacgtttctt 300 tagaaaacaa atgtatttca aaatatattt atagtcgaac aattcatata tttgaagtgg 360 agccatatga atgtcagtag tttatacttc tctattatct caaactactg gcaatttgta 420 aagaaatata tatgatatat aaatgtgatt gcagcttttc aatgttagcc acagt 475 <212> Type: DNA <211> Length: 475       SequenceName: # 384       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtgtgttg tcagcctgtg ctgtggcata gacatggatg cgaggaccac tttggagact 60 ggggtggcct caagagcaca cagagaaggg aagaaggggc catcacagga tgccacccct 120 gccttgggtt gggggcactc tgccacgacc agccccttcc tgggtattta ttctctattt 180 attggggata ggagaagagg catcctgcct gggtgggaca gccccttggg ccccttctcc 240 cctccccgcc tggccaggga gggccacccc actctacctc cttagctttc cctgtgccac 300 tttgactcag aggctgggag catagcagag gccaggccca ggcagagctg acgggaggcc 360 ccagctctga ggggaggggg tccgtggtag agcctggggc aggtagaggc tccccagggc 420 tcccttatgt ccaccacttc aggggatggg tgtggatgta attagctctg gggggcagtt 480 gggtagatgg gtgggggctc ctggtggcct tctgctgccc aggccacagc cgcctttggg 540 ttccatcttg ctaataaaca ct 562 <212> Type: DNA <211> Length: 562       SequenceName: # 385       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccaaagccat catccaggtg tctgctgccc tcttcacgct ctacaacaag aacattgaaa 60 ctcacctcaa ggaatttctg gtggtggcct ctgtcagcct cttgcagctg ggccaggaga 120 ctgacaagct taaaaccaga aatcgagaat ccatttctct gctcatgcgc ttggtggtgg 180 aggagtcatc cttcctgacc ctggacatgc tggagtcctg tttcccttat gtcctgcttc 240 gaaatgccta tcgggaggtg tctcgggcct tccacctaaa ctgaatgcct gccagtaccc 300 actgaagagc cctttggacc ttcctaaacc cttgccatag tggaagctgt ggtcactttc 360 gcagggggtg ggaatggggt ggggtcacta aggagagagg gtcaggagcc agagttgatg 420 agcagatctg tggaagaaca atccagggct gagaaatcgt agagcagtga ggcaggctgg 480 gagcatggag gac 493 <212> Type: DNA <211> Length: 493       SequenceName: # 386       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaaaaccag ccactgcttt acaggacagg gggttgaagc tgagccccgc ctcacaccca 60 cccccatgca ctcaaagatt ggattttaca gctacttgca attcaaaatt cagaagaata 120 aaaaatggga acatacagaa ctctaaaaga tagacatcag aaattgttaa gttaagcttt 180 ttcaaaaaat cagcaattcc ccagcgtagt caagggtgga cactgcacgc tctggcatga 240 tgggatggcg accgggcaag ctttcttcct cgagatgctc tgctgcttga gagctattgc 300 tttgttaaga tataaaaagg ggtttctttt tgtctttctg taaggtggac ttccagattt 360 tgattgaaag tcctagggtg attctatttc tgctgtgatt tatctgctga aagctcagct 420 ggggttgtgc aagctaggga cccattcctg tgtaatacaa tgtctgcacc aatgct 476 <212> Type: DNA <211> Length: 476       SequenceName: # 387       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagatgtcg gcagggctgg gcttcagcct ggaaggaggg aagggctccc tacacggaga 60 caagcctctc accattaaca ggattttcaa aggagcagcc tcagaacaaa gtgagacagt 120 ccagcctgga gatgaaatct tgcagctggg tggcactgcc atgcagggcc tcacacggtt 180 tgaagcctgg aacatcatca aggcactgcc tgatggacct gtcacgattg tcatcaggag 240 aaaaagcctc cagtccaagg aaaccacagc tgctggagac tcctaggcag gacatgctga 300 agccaaagcc aataacacac agctaacaca cagctcccat aaccgctgat tctcagggtc 360 tctgctgccg ccccacccag atgggggaaa gcacaggtgg gcttcccagt ggctgctgcc 420 caggcccaga ccttntagga cgccacccag caaaaggttg ttc 463 <212> Type: DNA <211> Length: 463       SequenceName: # 388       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtacaatagt gcatcttcca ctttctagag agaaagcatg cacttgttat ttggaaaact 60 gggctaaata tataacagta tccaaagtta taccataata atttattgta attgtgtatt 120 acatagcttt gtttacccag atataggtgc gttctttttt ttctgttagt catctgtgac 180 ttttgttctg gaatacaggt ttttaaatat atcttaacag tctgactaac ttaaaataat 240 ttattcttcc cttaaaacat ttttctgtgt ttttgtgcat caaatattgt agagttgaaa 300 tcttagagat tgcttatcga aatataaatt taggggaagt taaaaatcga ttggcaaatt 360 tgtagcattt attcactgat taaatctttt ccacttttgt gaaaaccata ccagtggttt 420 acatcanatt gtaatgtgtt catctcattc ttctttttat ccctaaacct agctaaaagt 480 tactgcaaag aaatctttgg ctgccacaag tagatgctct ctactaccag agctgga 537 <212> Type: DNA <211> Length: 537       SequenceName: # 389       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaatgacac ttacttacga cccaactaca gctgctatac agaacggatt ttatccttca 60 ccatacagta ttgctacaaa ccgaatgatc actcaaactt ctattacacc ctatattgca 120 tctcctgtat ctgcctacca ggtgcaaagt ccttcgtgga tgcaacctca accatatatt 180 ctacagcacc ctggtgccgt gttaactccc tcaatggagc acaccatgtc actacagccc 240 gcatcaatga tcagccctct ggcccagcag atgagtcatc tgtcactagg cagcaccgga 300 acatacatgc ctgcaacgtc agctatgcaa ggagcctact tgccacagta tg 352 <212> Type: DNA <211> Length: 352       SequenceName: # 390       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atctatgcaa acacctttcc cataaagaaa ccaaacccca tagtacagtg ccttgtccta 60 gtgttcacat gttcagctct gtttgtttag atgccaaggt ttccattttc agggctataa 120 aaagtattac ttggaaatga ggcatcagac caccagatgt taccgctcgg ttgaatgtgt 180 ccaccgtgga gtggtttggt gacgctgtaa ccattccacg ccagtgacct ctgctgggtc 240 acagccactc aggaggggaa gggtcaggat gagaggctgc agcctcgaca cttggcgcgg 300 cctgatactg aaatagcgtc tactcgtgca ctgaataaaa acagaaactt gatcatttta 360 ttcctgatta gattttatca ctctctgcta agacaatata gtctggagta taagtgggaa 420 agcttgattt aaatactgtg aactctaata atgtggaaaa tatttttcaa ctttaatttt 480 ctgaagtata aattatttat gtaaattcat tgtttttgca tatttcttag gacatgcatc 540 tttaagcttt atcattgccc atatgtac 568 <212> Type: DNA <211> Length: 568       SequenceName: # 391       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgacgacagt gaaattacca aagaggatga tgcattgtgg cctcctcctg accgagtggg 60 ccggcaggag cttgaaatcg tcattggaga tgaacacatt tcttttacaa catcaaaaat 120 tggttccctt attgatgtca atcaatccaa ggatccagaa ggcttacgag tattttatta 180 tcttgtccag gacctgaagt gtttggtctt cagtcttatt ggattacact tcaagattaa 240 accaatctag actgaatatt ggtgtggaca tggggggtgg gtgggagtag aaaattttgt 300 gtatatcagg gcagtatttt tttatga 327 <212> Type: DNA <211> Length: 327       SequenceName: # 392       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agttaaccac agcttcacag actaacatca agaaatcgcc aggaaaggtg aaagaagtta 60 atttgcaaaa gaaaaatgaa gactgtgaaa aaggaaatga ctccangaaa gttaaagtac 120 aaaaagtaca gtctgtcagc cagaataaaa gctacttggc cgtaaggcta aaagaccaag 180 atctgagaga ttcaaggcaa caagcagcac aagccttcat acataattca ttatatgggc 240 caggaaccaa caggantact gtaaataagt tcctgtctct tgccaacaag aggttaccag 300 tgaaaagagc tgctgtccag tttttgaata atgctt 336 <212> Type: DNA <211> Length: 336       SequenceName: # 393       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acagggtggt ggcacattat ccctctgggg ggtggggacg cctgttgttt tggctcaatt 60 tgggtttgtt ggtcacatgg agctcttcca tttcgtttag ctgaataatg agttgttcct 120 agaggagaca gcctgtctct ccttgttgcc cccaaagccc atgccctgcc gtggtggcag 180 ctggggctgt ggatgggagg ggtccccaac atggatgtgt tgcccctcct ccgcatgcca 240 acgcagttca tgtacaaggc ccctctgcaa ctggagagaa aattaattcc tatcccgtga 300 gtggattgtg agaaattcca cccacgtgga gacagcttac tgcagcactg ttggtgttcg 360 gagctcttct gtgccctggc tccatgcttt cacctacaca agcatcacct tcctaatcac 420 cgcggggcgg ggagcgtgtg gctgtgcccc ttctctttaa tctcatttaa tttttattaa 480 acatgctcag tacctgtgtt g 501 <212> Type: DNA <211> Length: 501       SequenceName: # 394       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgtgaagctt tacgcgcaca cggacaaaat gcccaaactg gagcccttgc aaaaacacgg 60 cttgtggcat tggcatactt gcccttacag gtggagtatc ttcgtcacac atctaaatga 120 gaaatcagtg acaacaagtc tttgaaatgg tgctatggat ttaccattcc ttattatcac 180 taatcatcta aacaactcac tggaaatcca attaacaatt ttacaacata agatagaatg 240 gagacctgaa taattctgtg taatataaat ggtttataac tgcttttgta cctagctagg 300 ctgctattat tactataatg agtaaatcat aaagccttca tcactcccac atttttctta 360 cggtcggagc atcagaacaa gcgtctagac tccttgggac cgtgagttcc tagagcttgg 420 ctgggtctag gctgttctgt gcctccaagg actgtctggc aatgacttgt attggccacc 480 aactgtagat gtatatatgg tgcccttctg atgctaagac tccagacctt ttgt 534 <212> Type: DNA <211> Length: 534       SequenceName: # 395       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgcggcggag cctccttaag gaaggtgcaa gaggttggca gcttcgattg aagcacatcg 60 accggcgaca gcagccagga gtcatgagcg acagcggcga gcagaactac ggcga 115 <212> Type: DNA <211> Length: 115       SequenceName: # 396       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgtaatgcc caaatgtagc taaaaaaatc aacgtgagta cagtgagaca caattttgtg 60 tctgtacaat tatgaaaaat taaaaacaaa gaaaatattc aaagctacca aagatagaaa 120 aaactggtag agccacatat tgttggtgaa ttattaagac ccttttaaaa atcattcatg 180 gtagagttta agagtcataa aaaagattgc atcatctgac ctaagacttt cggaattttt 240 cctgaacaaa taacagaaag ggaattatat accttttaat attattagaa gcattatctg 300 tagttgtaaa acattattaa tagcagccat ccaattgtat gcaactaatt aaggtattga 360 atgtttattt tccaaaaatg cataattata atattatttt aaacactatg tatcaatatt 420 taagcaggtt tataatatac cagcagccac aattgctaaa atgaaaatca tttaaattat 480 gattttaaat ggtatacaca tgatttctat gttgatagta ctatattatt ctacaata 538 <212> Type: DNA <211> Length: 538       SequenceName: # 397       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcgagtgatt cgctggatcc tgtcaattgg ccttaaagaa tatgcaaaca atcttataga 60 gagtggtgtt cacggagcac ttctggcctt agatgaaacc ttcgacttca gtgcactggc 120 actgctgtta cagatcccga cgcagaacac acaggctcgt gctgtcttgg aaagagaatt 180 taacaacctt ttggtcatgg ggactgatag aaggtttgat gaagatgatg ataaaagctt 240 taggagagca ccttcatgga gaaaaaagtt tagaccaaag gacattcgtg gcttagctgc 300 tgggtcagca gagactctcc ctgcaaactt ccgggtgact tc 342 <212> Type: DNA <211> Length: 342       SequenceName: # 398       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagcaacac cagaaaatga tcctaactac tttatgaatg aaccaacatt ttatacatct 60 gatggtgttc ctttcactgc agctgatcca gattaccaag agaaatacca agaattactt 120 gaaagagagg acttttttcc agattatgaa gaaaatggaa cagatttatc cggggctggt 180 gatccatact tggatgatat tgatgatgag atggacccag agatagaaga agcttatgaa 240 aagttttgtt tggaatcaga gcgtaagcga aaacagtaaa gttaaatttc agcatatcag 300 ttttataaag cagtttaggt atggtgattt agcagaacac aagagagcaa gaaaatgtgt 360 cacatctata ccaaattaag gatgttgagt tatgttacta atgtatgcaa ctttaatttt 420 gtttaacact atctgccaaa ataaacttta ttccctataa cttaaaatgt gtatatatat 480 ataatagttt attatgtaca gttaattcta ctgttttggc tgcaa 525 <212> Type: DNA <211> Length: 525       SequenceName: # 399       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaactagtc tgtcatcggg aaaaagtttc actgctacat aggattttgt caaattgaag 60 gtgtgacaag atggtgttct gctaatgtta aatgtcagcc cacagagcta ataatacctc 120 agtataatgt catgagcagt tgaaattcat cacatgaaaa gtaatctgct gaaagacttg 180 gttgcccact gcctaactgt gtacagtgtt accagtgtcc cattatggat aattctcaat 240 atgttaacac ctaggtgttc ccaatacctt tttcccctca tgtcactact gaattttgac 300 aggaggaagg aatagaatga tagcttgttt tatttgtaaa gctttcagtg aaacactaca 360 tacacgaaga aaaggaacaa ggtttaacta tttaagaacc atttgctgcc gcatagtgcc 420 attggatagg gaagaacttc agaaatctgt ggtactcttg gccttgt 467 <212> Type: DNA <211> Length: 467       SequenceName: # 400       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cccattcggc gtagtaccca gagagctcaa gatgtgtggc agttttcgga tggaagctcg 60 agagccctta agttctgaga aaatttgaag cccccagggg tggggtggac gcgtgccgcc 120 cagtcgacgt cagcgtggtc tgtcatcctg ctagtttgtg atgttttctg acagtagcct 180 ccaagaagcc gttgtgcgaa gacagagtcc tgcagagtcc ttccagccta ggcctgcagc 240 gccattttat ttatattttt taataaaaag taaaaacaaa aaaacagacc cacattggaa 300 cagtgaatca gtcccataga gagggcccgt ggaccatcgc tgtcatgagt gatgccctgg 360 cccttctgaa accagccaac ctaattacct gtattgtgga aatgcgcatg agtccccaac 420 cccttgtttc tatacattct 440 <212> Type: DNA <211> Length: 440       SequenceName: # 401       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgggaatccc aggatgctgc ccaacgggaa atttgtacat tgggtgctat gaatgccaca 60 tcacagggac cagccatcac agagcaaagt gacctccacg tctgatgctg gggtcatcag 120 gacggaccca tcatggctat ctttttgccc caccccctgc cgtcagttct tcctttctcc 180 gtggctggct tcccgcacta gggaacgggt tgtaaatggg gaacatgact tccttccgga 240 gtccttgagc acctcagcta aggaccgcag tgccctgtag agttcctaga ttacctcact 300 gggaatagca ttgtgcgtgt ccggaaaagg gctccatttg gttccagccc actcccctct 360 gcaagtgccg cagcttccct caggcatact ctccagtgga tccaagtact ctctctccta 420 aagacaccac cttcctgcca gctgtttgcc cttaggccag tacacagaat tgaaagtggg 480 ggaggtggca gacgctttct gggacctgcc caagatatgt attctctgac actcttattt 540 ggt 543 <212> Type: DNA <211> Length: 543       SequenceName: # 402       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccggcgggtg acattcagcc ggcggttcgg ggcgacggac tctccattcc agaaccatgg 60 cccaatttgt ccgtaacctt gtggagaaga ccccggcgct ggtgaacgct gctgtgactt 120 actcgaagcc tcgattggcc acattttggt actacgccaa ggttgagctg gttcctccca 180 cccctgctga gatccctaga gctattcaga gcctgaaaaa aatagtcaat agtgctcaga 240 ctggtagctt caaacagctc acagttaagg aagctgtgct gaatggtttg gtggccactg 300 aggtgttgat gtggttttat gtcggagaga ttataggcaa gcggggcatc attggctatg 360 atgtttgaag accaatcttt aacatctgat tatatttgat ttattatttg agtgttgttg 420 gaccatgtgt gatcagactg ctat 444 <212> Type: DNA <211> Length: 444       SequenceName: # 403       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacatccgcc tggtaaccag tcgctctggc tgggcacttc cacccgcacc tcattcctac 60 atcaatgagt ggctccaaat agacctgggg gaggagaaga tcgtgagggg catcatcatt 120 cagggtggga agcaccgaga gaacaaggtg ttcatgagga agttcaagat cgggtacagc 180 aacaacggct cggactggaa gatgatcatg gatgacagca aacgcaaggc gaagtctttt 240 gagggcaaca acaactatga tacacctgag ctgcggactt ttccagctct ctccacgcga 300 ttcatcagga tctaccccga gagagccact catggcggac tggggctcag aatggagctg 360 ctgggctgtg aagtggaagc ccctacagct ggaccgacca ctcccaacgg gaacttggtg 420 gatgaatgtg atgacgacca ggccaactgc cacagtggaa ca 462 <212> Type: DNA <211> Length: 462       SequenceName: # 404       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtgaggcg atttgacctg ctcaaacgta tcttgaagat ggacagaaaa gctgtggaga 60 cccacctgct caggaaccct caccttgttt cggactatag agtgctgatg gcagagattg 120 gtgaggattt ggataaatct gatgtgtcct cattaatttt cctcatgaag gattacatgg 180 gccgaggcaa gataagcaag gagaagagtt tcttggacct tgtggttgag ttggagaaac 240 taaatctggt tgccccagat caactggatt tattagaaaa atgcctaaag aacatccaca 300 gaatagacct gaagacaaaa atccagaagt acaagcagtc tgttcaagga gcagggacaa 360 gttacaggaa tgttctccaa gcagcaatcc aaaagagtct caaggatcct tcaaataact 420 tcaggatgat aacaccctat gcccattgtc ctgatctgaa aattcttgga aattgttcca 480 tgtgattaac atggaactgc ctctacttaa tcattct 517 <212> Type: DNA <211> Length: 517       SequenceName: # 405       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgaattact ttgttacatg cccattagtg gcctccttaa gagttcatcc ttcctagatt 60 aaaaataact ggtctaagtt gtgactattc ttcttaattg aaccatgaag tgaaacaagt 120 agtatccaga cattcagctc atagctttct gagcttctgt agccaaatat ccttcaggaa 180 gtttacttgt tagatatcta aagggaaaag aaactgccat ctccatatga aagtaagaaa 240 caggactttt ttgcatatca taaaaaatag ggtttgcctg ggtgcgatgg ctcatgcctg 300 taatcccagc actttgagaa gctgaggcgg gtgggttgct tgagcctggc agtttgaaac 360 cagtttgaga tggggttttg cagaaaccac atctctgaaa aaaaaacaaa agaaaagcca 420 agtgtggtgg cacacgcctg agtccccagc tacttgggag gctgagaagg tgggagcaac 480 acgtgagtcc tgga 494 <212> Type: DNA <211> Length: 494       SequenceName: # 406       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtactattcc atgaaccaag tcctctggaa gcttcccggg gttgcctgta aacactctgc 60 cacaaacctc aggcttttta cagaccccgt cacacatcca tagtgaaatt tctcataaaa 120 aaggaatgat tgcaggatcc cagtgtgccc tttcaattgc cctcttgtgg aaggggttct 180 tttcttcata aaccctaaag tggtcagtta atattgatta gaaacaaagc ctcagattta 240 ctcctcatat cagaacaacc agccttctca tttttgcatt agttcatgac tgaatcaatt 300 gaaactgaag gctttgaatg aaatagggcg agtatgttag cctggagcaa attgtgtatg 360 gcagcgagtt acaaaccaca gaaaatgggt catttatagt ggaaacactg acaacctttc 420 aaaactataa ggttttgctt tacctacagt gtttca 456 <212> Type: DNA <211> Length: 456       SequenceName: # 407       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcattccacc ggcggctacg gtggtggcaa ttccggcggc ggcggcggcg gcctacgggg 60 gcggcactcc ggcggcggca gcagctccgg cggcggatac ggcggcggca gctccagcgg 120 aggccacaag tcctcctctt ccgggtccgt gggcgagtct tcatctaagg gaccaagata 180 ctaacaaaac cagagtaatc aagacaatta ttgaagaggt ggcgcccgac ggtagagttc 240 tttcatctat ggttgaatca gaaaccaaga aacactacta ttaaactgca tcaagaggag 300 agagtctccc ttcacacaga ccattaattt acagatgcat ggaaaacaaa gtctccaaga 360 aaacacttct gtcttgatgg tctatggaaa tagaccttga aaataaggtg tctacaaggt 420 gttttgtggt ttctgtattt cttcttttca ctttaccaga aagtgttctt taatggaaag 480 aaaaacaact ttctgttctc atttactaat gaatttcaat aaactttctt actgatgcaa 540 acgtctgaga ttact 555 <212> Type: DNA <211> Length: 555       SequenceName: # 408       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: attggtttgc tatttgatct tcttgcatca agttcagctc ttccttggaa catcacagta 60 cattttaaga gttttccaga aaaagacctt ctgcactgtc catctaagga tgcaattgaa 120 gctcatttta tgtcatgtat gaaagaagct gatgctttaa aacataaaag tcaagtaatc 180 aatgaaatgc agaaaaaaga tcacaagcaa ctctggatgg gattgcaaaa tgacagattt 240 gaccagtttt gggccatcaa tcggaaactc atggaatatc ctgcagaaga aaatggattt 300 cgttatatcc cctttagaat atatcagaca acgactgaaa gacctttcat tcagaagctg 360 tttcgtcctg tggctgcaga tggacagttg cacacactag gagatctcct caaagaagtt 420 tgtccttctg ctattgatcc tgaagatggg gaaaaaaaga atcaagtgat gattcatgga 480 attgagccaa tgttggaaac acctctgcag tggctgagtg aacatctgag ctacccgga 539 <212> Type: DNA <211> Length: 539       SequenceName: # 409       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacgagaacc actcagagtt tactctgtac gaatcacggc tgttggacat ctcggtatca 60 ccgttgatga actcattggt ttcacaagtc atttgtgatg tactgttttt gattggccag 120 tcatgacagc cgtgggacac ctcccccccc gtgtgtgtgt gcgtgtgtgg agaacttaga 180 aactgactgt tgccctttat ttatgcaaaa ccacctcaga atccagttta ccctgtgctg 240 tccagcttct cccttgggaa aaagtctctc ctgtttctct ctcctccttc cacctcccct 300 ccctccatca cctcacgcct ttctgttcct tgtcctcacc ttactcccct caggacccta 360 ccccaccctc tttgaaaaga caaagctctg cctacataga 400 <212> Type: DNA <211> Length: 400       SequenceName: # 410       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgtgctgtt gggtctttca gctcctcggg tggtagggag gacacaggct ggggaggtgg 60 cagtgttggg tggagtccag ctcagggccc caccctctcc cctgcagggt acctgtcagt 120 aaacctaggg gtggggtgag gacacctgag ggcctcccgt gtggccagca ttgctgttgc 180 tgacttattg cccaatgagg gggctgtgct taggtagggg ctgctatcca ctctggaaat 240 taagtcagaa agatgagtgt aatctggtac ccaggatcta tagggtccca gagacggaca 300 ttccttacct caaatgctgc ctgataaact ggctctcttt 340 <212> Type: DNA <211> Length: 340       SequenceName: # 411       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcttctcagg gaatccgaca ccagccaacc attttaagcc tctaaaagac ctcgggcaag 60 tctcacagaa actgagctgc agacggggag tagctttgtg gaaactgatt tgatggacac 120 tgcaccagct tccttcaggt tctagattct tgctacttag ggcgggctgg tttggaccta 180 acatctcgca cgtgactccc tcagcctcag agccttggga tgcagagcag ctggcagggt 240 tcctctcaat cctgcaaccc cagctgtccc accggtggat gcagagggga atccgaggcc 300 atcaaccttg gtgacagcag cgcagtgcca atgctgatca cactgcatgg gagattttgt 360 taacgtctgc cacccccact ctcaccccca agctctaagc ccccgggagg cctggactgt 420 cttcctcatc tctgtagcac caagcctgat agatctgt 458 <212> Type: DNA <211> Length: 458       SequenceName: # 412       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcccatcctg cacacttact ggatgctttg gactcaacag gacatatgtg gccttgaagg 60 gaagacaaaa ctggatgttc tttcttgttg gatagaacct ttgtatttgt ttctttaaaa 120 acattttttt taatgttggt aacttttgct tcctctacct gaacaaagag a 171 <212> Type: DNA <211> Length: 171       SequenceName: # 413       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggagagtcc cattgctaaa attcagctac tcagataaat tcagaatggg tcaaggcacc 60 tgcctgtttt tgttggtgca cagagattga cttgattcag agagacaatt cactccatcc 120 ctatggcaga ggaatgggtt agccctaatg tagaatgtca ttgtttttaa aactgtttta 180 tatcttaaga gtgccttatt aaagtataga tgtatgtctt aaaatgtggg tgataggaat 240 tttaaagatt tatataatgc atcaaaagcc ttagaataag aaaagctttt tttaaattgc 300 tttatctgta tatctgaact cttgaaactt atagctaaaa cactaggatt tatctgcagt 360 gttcagggag ataattctgc ctttaattgt ctaaaacaaa aacaaaacca gccaacctat 420 gttacacgtg agattaaaac caattttttc cccatttttt ctcctttttt ctcttgctgc 480 ccacattgtg cctttatttt atgagcccca gttttctggg cttagtt 527 <212> Type: DNA <211> Length: 527       SequenceName: # 414       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacattgcct gtatgatcgg gtaccgacct tgcccctgga tgaaatggtg ctggtccttc 60 ttcaccccgc tggtctgcat gggcatcttc atcttcaacg ttgtgtacta cgagccgctg 120 gtctacaaca acacctacgt gtacccgtgg tggggtgagg ccatgggctg ggccttcgcc 180 ctgtcctcca tgctgtgcgt gccgctgcac ctcctgggct gcctcctcag ggcaaagggc 240 accatggctg agcgctggca gcacctgacc cagcccatct ggggcctcca ccacttggag 300 taccgagctc aggacgcaga tgtcaggggc ctgaccaccc tgaccccagt gtccgagagc 360 agcaaggtcg tcgtggtgga gagtgtcatg tgacaactca gctcacatca ccagctcacc 420 tctggtagcc atagcagccc ctgcttcagc cccaccgcac ccctccaggg ggcctgcctt 480 tccctgacac ttttggggtc tgc 503 <212> Type: DNA <211> Length: 503       SequenceName: # 415       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tacattgttc ccttggtcgt agtttacttt gccgagtatt tcattaacca gggacttttt 60 gaactcctct ttttctggaa cacttccctg agtcacgctc agcaataccg ctggtaagag 120 gagcgagggc agtgggctgg gagggcgccg tggtgatgca gctgccctgc ccagtaggca 180 ccggggggag cgggatggtc cctggaggag cctcctctcc tccccccaac cctaacctca 240 ggtaccagat gctgtaccag gctggcgtct ttgcctcccg ctcttctctc cgctgctgtc 300 gcatccgttt cacctgggcc ctggccctgc tgcagtgcct caacctggtg ttcctgctgg 360 cagacgtgtg gttcggcttt ctgccaagca tctacctcgt cttcctgatc attctgtatg 420 aggggctcct gggaggcgca gcctacgtga acaccttcca caacatcgcc ctggagacca 480 gtgatgagca ccgggagttt gcaatggcgg ccacctgcat ctctgacaca ctggggatct 540 <212> Type: DNA <211> Length: 540       SequenceName: # 416       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaggagacg gtctggcggc ttgaagaatt tggacgattt gccagctttg aggctcaagg 60 tgcattggcc aacatagctg tggacaaagc caacttggaa atcatgacaa agcgctccaa 120 ctatactccg atcaccaatg acaagttcac cccaccagtg gtcaatgtca cgtggcttcg 180 aaatggaaaa cctgtcacca caggagtgtc agagacagtc ttcctgccca gggaagacca 240 ccttttccgc aagttccact atctcccctt cctgccctca actgaggacg tttacgactg 300 cagggtggag cactggggct tggatgagcc tcttctcaag cactgggagt ttgatgctcc 360 aagccctctc ccagagacta cagagaacgt ggtgtgtgcc ctgggcctga ctgtgggtct 420 ggtgggcatc attattggga ccatc 445 <212> Type: DNA <211> Length: 445       SequenceName: # 417       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagcaccctg tatcacagac tggcaacaag aagatggtac cgtgcatcgc acctatttaa 60 gagggaactt agcagagagc aaatgctatt tgataacagt tactccagta tatgctgatg 120 gaccaggaag ccctgaatcc ataaaggcat accttaaaca agctccacct tccaaaggac 180 ctactgttcg gacaaaaaaa gtagggaaaa acgaagctgt cttagagtgg gaccaacttc 240 ctgttgatgt tcagaatgga tttatcagaa attatactat attttataga accatcattg 300 gaaatgaaac tgctgtgaat gtggattctt cccacacaga atatacattg tcctctttga 360 ctagtgacac attgtacatg gtacgaatgg cagcatacac agat 404 <212> Type: DNA <211> Length: 404       SequenceName: # 418       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaaagactg atttccagcg tcctgcaggg gctgcggaga cagagcccaa ggacaggggc 60 ctgctgagga ggtccagccc agctgctgac gtccaggaag aaaacctcta gcccacacga 120 tgaagacccc caggcagtga cgtatgcccc ggtgaaacac tccagtccta ggagagaaat 180 ggcctctcct ccctcctcac tgtctgggga attcctggac acaaaggaca gacaggtgga 240 agaggacagg cagatggaca ctgaggctgc tgcatctgaa gcctcccagg atgtgaccta 300 cgcccagctg cacagcttga cccttagacg gaaggcaact gagcctcctc catcccagga 360 aggggaacct ccagctgagc ccagcatcta cgccactctg gccatccact agcccggggg 420 gtacgcagac cccacactca gcagaaggag actcaggact gctgaaggca cgggagctgc 480 ccccagtgga caccagtgaa ccccagtcag cctggacccc taacacagac catgagga 538 <212> Type: DNA <211> Length: 538       SequenceName: # 419       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa 60 ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc 120 caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga 180 gctgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat 240 cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt 300 gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg 360 gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac 420 gcagaagag 429 <212> Type: DNA <211> Length: 429       SequenceName: # 420       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggggagcaa aggcagtccg agccctgaag aacagtaatg atattgtaaa tgctattatg 60 gaattaacaa tgtaaccatc tgaaagcaac ttttttggtg tctcagatga gtaactgcag 120 cttggtttga aatttgtact gtttctatca taaataaagt tatggcttct tgttggatga 180 aaaaaaaaag acagtatttt gccaaattaa acagaaaaga gagttcagtg gaagatggct 240 ctgatttcag ggtaataata atggtaggta acaattaaat ggcatttaaa aatttgctga 300 atgcttgcta cgagcggtgg ctcatgcctg aatctcagca ctttgggagg ccaaggcagg 360 cagatcatct gaggtcatga gttcgagacc agcctggcca acatgatgaa accctgtctc 420 tactaaaaat acaaaaatta gctgggcatg gtggtgcaca cctgtaatcc cagttactca 480 ggaggctgag gcaggagaat cacttgaatc cagaaggcgg aggttgcagt gagctgagat 540 tgcaccacgg ca 552 <212> Type: DNA <211> Length: 552       SequenceName: # 421       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccaaggcag gcgatcacat gaggttggga gttcaagacc agcctagacc cgccaacatg 60 ggccgcgttc gcaccaaaac cgtgaagaag gcggcccggg tcatcataga aaagtactac 120 acgcgcctgg gcaacgactt ccacacgaac aagcgcgtgt gcgaggagat cgccattatc 180 cccagcaaaa agctccgcaa caagatagca ggttatgtca cgcatctgat gaagcgaatt 240 cagagaggcc cagtaagagg tatctccatc aagctgcagg aggaggagag agaaaggaga 300 gacaattatg ttcctgaggt ctcagccttg gatcaggaga ttattgaagt agatcctgac 360 actaaggaaa tgctgaagct tttggacttc ggcagtctgt ccaaccttca ggtcactcag 420 cctacagttg ggatgaattt caaaacgcct cgggga 456 <212> Type: DNA <211> Length: 456       SequenceName: # 422       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctcctctcca cctgctggtg agaggtgcaa agaggcagat ctttgctgcc agccacttca 60 tcccctccca gatgttggac caacacccct ccctgccacc aggcactgcc tgagggcagg 120 gagtgggagc caatgaacag gcatgcaagt gagagcttcc tgagctttct cctgtcggtt 180 tggtctgttt tgccttcacc cataagcccc tcgcactctg gtggcaggtg cttgtcctca 240 gggctacagc agtagggagg tcagtgcttc gagccacgat tgaaggtgac ctctgcccca 300 gataggtggt gccagtggct tattaattcc gatactagtt tgctttgctg accaaatgcc 360 tggtaccaga ggatggtgag gcgaaggcag gttgggggca gtgttgtggc ctggggccag 420 ccaacactgg ggctctgtat atagctatga agaaaacaca aagttgataa atctgagtat 480 atatttacat gtctttttaa aagggtcgtt accagagatt tacccatcg 529 <212> Type: DNA <211> Length: 529       SequenceName: # 423       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgccgggc aagtcagggc 60 attagaaatg atttagcctg gtatcagcag aaaccaggga aagcccctaa gcgcctgatc 120 tatgctgcat ccagtttgca aagtggggtc ccatcaaggt tcagcggcag tggatctggg 180 acagaattca ctctcacaat cagcagcctg cagcctgaag attttgcaac ttattactgt 240 ctacagcata atagttaccc ttg 263 <212> Type: DNA <211> Length: 263       SequenceName: # 424       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgcttcact tgtggcaaga tcgtcggcaa caagtgggag gcttacctgg ggctgctgca 60 ggccgagtac accgaggggg atgcgctgga tgccctgggc ctgaagcgct actgctgccg 120 ccggatgctg ctggcccacg tggacctgat cgagaagctg ctcaattatg cacccctgga 180 gaagtgacca cgctggaacc cacccacccg ctgtgctgac catgggccct gagcgtcctg 240 ccccgaattc acgaggctga ggcatccggg agctggcgta atgcctggcc gcagtgtgtg 300 tgtatcccat accccactct ggaaggaacc atccagtaaa ggtctttca 349 <212> Type: DNA <211> Length: 349       SequenceName: # 425       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctgttgag tctatctcag tgccagatat ggtggacaaa aaccttacgt gtcctgagga 60 agaggacaca gtaaaagtgg tgggcatccc tgggtgccag acctgccgct acctcctggt 120 gagaagtctt cagacgttta gtcaagcttg gtttacttgc cggaggtgct acaggggcaa 180 cctggtttcc atccacaact tcaatattaa ttatcgaatc cagtgttctg tcagcgcgct 240 caaccagggt caagtctgga ttggaggcag gatcacaggc tcgggtcgct gcagacgctt 300 tcagtgggtt gacggcagcc gctggaactt tgcgtactgg gctgctcacc agccctggtc 360 ccgcggtggt cactgcgtgg ccctgtgtac ccgaggaggc tactggcgtc gagcccactg 420 cctcagaaga cttcctttca tctgttccta ctgagctggt cccagccagc agttcagagc 480 tgccctctcc tgggcagctg cctcccctcc tctgcttgcc atccctccct ccacctccct 540 gcaataaaat gg 552 <212> Type: DNA <211> Length: 552       SequenceName: # 426       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ataggatcaa gaattcacat cgtgatgaag agtgataagg aaattgttgg tactcttcta 60 ggatttgatg actttgtcaa tatggtactg gaagatgtca ctgagtttga aatcacacca 120 gaaggaagaa ggattactaa attagatcag attttgctaa atggaaataa tataacaatg 180 ctggttcctg gaggagaagg acctgaagtg tgaatgagtt tccttgactt acactagatt 240 ttgttttggc ttataatgac aagaaaatgg aatttttttt cccactttct aatgtttaaa 300 tcccataaag ctaagtttcc cgttaaaggg aagtgctttg aagatgtgta cccatttttg 360 taa 363 <212> Type: DNA <211> Length: 363       SequenceName: # 427       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acaatgtcaa acatcacagc cggccgccag gaccagatac agcaagttgt gaatcatgga 60 ttagtcccat tccttgtcag cgttctctct aaggcagatt ttaagacaca aaaggaagct 120 gtgtgggccg tgaccaacta taccagtggt ggaacagttg aacagattgt gtaccttgtt 180 cactgtggca taatagaacc gttgatgaac ctcttaactg caaaagatac caagattatt 240 ctggttatcc tggatgccat ttcaaatatc tttcaggctg ctgagaacct aggtgaaact 300 gagaaactta gtataatgat tgaagaatgt ggaggcttag acaaaattga agctctacaa 360 aaccatgaaa atgagtctgt gtataaggct tcgttaagct taattgagaa gtatttctct 420 gtagaggaag aggaagatca aaacgttgta ccagaaacta cctctgaagg ctacactttc 480 caagttcagg atggggctcc 500 <212> Type: DNA <211> Length: 500       SequenceName: # 428       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggctgcctc gggaacagta agaccgagga ccagcgcaac gaggagaagg cgcagcgtga 60 ggccaacaaa aagatcgaga agcagctgca gaaggacaag tacttcattc gagatgagtt 120 tctgaggatc agcactgcca gtggagatgg gcgtcactac tgctaccctc atttcacctg 180 cgctgtggac actgagaaca tccgccgtgt gttcaacgac tgccgtgaca tcattcagcg 240 catgcacctt cgtcagtacg agctgct 267 <212> Type: DNA <211> Length: 267       SequenceName: # 429       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tacctaacgg cggctgccat tttcaggggt cgcatgccca tgagggaggt ggatgaacag 60 atgttcaaca ttcaagataa gaacagcagc tactttgctg actggctccc caacaacata 120 aaaacagccg tctgtgacat cccaccctgg gggctaaaaa tgtcagtcac cttcactggg 180 aacaacacag ccgtccagga actcaagcgg gtctcagagc agtttacagc aacgttcagg 240 cgcaaggcct tcctccactg gtacacgggc gagggcatgg atgagatgga attcactgag 300 gccgagagca acatgaacga cttggtgtct gaatatcagc aatatcagga tgccacggcc 360 gagggagaag gag 373 <212> Type: DNA <211> Length: 373       SequenceName: # 430       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtcagacg cagccgtaga caccagctcc gaaatcacca ccaaggactt aaaggagaag 60 aaggaagttg tggaagaggc agaaaatgga agagacgccc ctgctaacgg gaatgctaat 120 gaggaaaatg gggagcagga ggctgacaat gaggtagacg aagaagagga agaaggtggg 180 gaggaagagg aggaggaaga agaaggtgat ggtgaggaag aggatggaga tgaagatgag 240 gaagctgagt cagctacggg caagcgggca gctgaagatg atgaggatga cgatgtcgat 300 accaagaagc agaagaccga cgaggatgac tag 333 <212> Type: DNA <211> Length: 333       SequenceName: # 431       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttttgctcca gctagtgctt acagtttcat tcgagccctg agtatgtgcc ctgctgttac 60 tctctttggt agttgaacgt tgaattcaag tcttttgttt taagaagtac taagcaaaca 120 agcaataaaa aggggaatgg ggtgtgctag tgtttgaata tgctctcttg ttgctctaat 180 tctgtgcctc tgtgcattaa tatttggatg catgcaatgc cagcatggaa attggtcttc 240 acanatactg cagttttcca gaaacattca caaaccaata aatgtaacag acattccatt 300 tgttaatggg catatatgtg aaaagcagtg tagaaaatag gctaatatta gaaaatggtt 360 aagtcctaaa taacttcaag tgtggttata taatggacac tgtcaatgtt cataacttaa 420 acctgggtac ctggtcaaaa taatgcttgg g 451 <212> Type: DNA <211> Length: 451       SequenceName: # 432       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttgatcttgg tttgcaagcc cttctcccat cagtcctaga ttaggccctg ttcagccatg 60 caggggtgtt ggtttatgcg tgctgcagca gtgggcataa tgaatataat ttacccagtg 120 gacaaaggtg tgtaccaagt gaatttaaat aattggtgtg gattnggcca gtagctaagn 180 nntgggcttt taaagagtat tgaagattga anagggtttt tctttctttt ttaaaaaaga 240 aaaacaaact attgattgta gataatgaaa agctagggtt tgccctcttc atgtctactc 300 tccttccaaa tagttatatc caaaactgtt tttccctctc ccctaccttg tcccccctat 360 taaaatagaa acagggattg attaatgtcc cgctcctgaa tacat 405 <212> Type: DNA <211> Length: 405       SequenceName: # 433       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgtcttcaca gcgtccctaa ggaagatttt tgcagcactc tctggagctg aggggagtga 60 aatttggtcc agagaaggcg gaaggaaata gttttcctgt ttccttttct cgaggtggat 120 gtcctcaggc ttccttcaca cctccttctc atgggtncgg ntggcagtac agtcaggctg 180 tggaggaggg ctgagaagaa aggggcactg gtccagcccc anggtttggt ctgagacagg 240 tacacagcag ataccatccc accttcctct ctaaagaaca ggccagccac acatataacc 300 ctttccctac tttactaatg tatcccttat gtggtaccag caatggagga caggcagact 360 taccccctgc catctagaga gaatgttgtt attacccgta aaacttgacc acccccatat 420 cccactcctt tttgtaaaaa caaatgctta aacctgtgag cctgccgttc ctttctatgt 480 gttaatcagt ttccttccat ttgagctgt 509 <212> Type: DNA <211> Length: 509       SequenceName: # 434       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggcaaatg gatctcgata tttcagatgg gcttttgatg cactgttgcc aaggaaggct 60 ttttctgatt ttttgacaaa tgaatttttg cacactttca ttggtgtctt tcggcaactt 120 acacacattg aaaat 135 <212> Type: DNA <211> Length: 135       SequenceName: # 435       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caaaaggagc ggcgcggtct tcgtggtgtt cgtggcaggt gatgatgaac agtctacaca 60 gatggctgca agttgggaag atgataaagt tacagaagca tcttcaaaca gttttgttgc 120 tattaaaatc gataccaaaa gtgaagcctg cctacagttt tcacaaatct atcctgtagt 180 gtgtgttcca tccagtttct ttattggaga cagtggaatt cccttggaag taatagcagg 240 aagtgtttct gcagatganc ttgttacaag aattcacaag gtccgacaga tgcatttgct 300 aaaaagtgaa acatcagtag caaatggcag tcagtcagaa agttcagtgt ctactccatc 360 tgcgtcattt gaacctaaca acacttgtga aaactctcag tccagaaatg cagagctttg 420 tgagatacca cccacttctg atacaaagtc agatactgca acaggaggag aaagtgcagg 480 ccatgccact tcctctcagg agcctagtgg atgctcagat cagagacctg cagaggacct 540 caacatccga gtg 553 <212> Type: DNA <211> Length: 553       SequenceName: # 436       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctcaggcac tcagatgaca gcagattctg ggttctggga gtgttctgtg cctcttacat 60 gccctggagg cctcatggtc tcagtgctga ggcggcacac ctgtagcaca cctgcgtaat 120 gtgcggtctg ggccagtcac aaggaattgt gttgtctaag ccaaaggggg aagctgactg 180 tgatttacca aaaaaaattc tgtaattcaa accaaaatgt ctgcggaatc accagtttga 240 tactctctgt aatcagaaca gtgggcagtg cctgggtgaa cgtgtctagc agccactgtg 300 cgggatcgct gtaacaggag tggaatgtac atatttattt acttttctaa ctgctccaac 360 agccaaatgc ct 372 <212> Type: DNA <211> Length: 372       SequenceName: # 437       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaatcggggt tccatcacaa gctatgttta aaaagaaaat tggtgtttgg caaacggaac 60 agaacctttg atgagagcgt tcacagggac actgtctggg ggtgcagtgc aagcccccgg 120 cctcttccct gggaacctct gaactcctcc ttcctctggg ctctctgtaa catttcacca 180 cacgtcagca tctaatccca agacaaacat tcccgctgct cgaagcagct gtatagcctg 240 tgactctccg tgtgtcagct ccttccacac ctgattagaa cattcataag ccacatttag 300 aaacagnttt gctttcagct gtcacttgca cacatactgc ctagttgtga accaaatgtg 360 aaaaaacctc cttcatccca ttgtgtatct gatacctgcc gagggccaag ggtgtgtgtt 420 gacaacgccg ctcccagccg gccctggttg cgtccacgtc ctgaacaaga gccgcttccg 480 gatggctctt cccaagggag gaggagctca agtgtcggga actgtct 527 <212> Type: DNA <211> Length: 527       SequenceName: # 438       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagaaagaac gggagcggga acgagaacgg gatagggacc gtgaccggac aaaagagaga 60 gaccgagatc gggatcgaga gagagatcgt gaccgggata gagaaaggag ctcagatcgt 120 aataaggatc gcagtcgatc aagagaaaaa agcagagatc gtgaaaggga acgagagcgg 180 gaaagagaga gagagagaga acgagagcga gaacgagaac gggagcgaga gagagagcga 240 gagagggaac gggagcgaga aagagaaaaa gacaaaaaac gggaccgaga agaagatgaa 300 gaagatgcat acgaacgaag aaaacttgaa agaaaactcc gagagaaaga agctgcttat 360 caagagcgcc ttaagaattg ggaaatca 388 <212> Type: DNA <211> Length: 388       SequenceName: # 439       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttacatgagg ggttcttcac gattctcctg gaacccagtc tagcaaaatg agaggaaagg 60 ccctagggag atttatttct gttaaatagt taactctgct gagtatgaca aatagtgtct 120 actatctcaa ccctccaaaa tttgcagagt gttgggactg tcatttgtga nttttttttt 180 ttttttttgg tggggtagtt gaataaaatt gggcagctaa atttttcagt tccatgtgcc 240 tcccaaataa aaaacagaaa ataagtagtt tttgtgaatt gacttgcaga caaagtagaa 300 actgtgctgc atgatgttat tttgtaaaca gatgacattt tctgaccagg cacatgccat 360 ccaattttct gtcaatcaca ctgttgtata aagcagcaga actgaagggg aaaaatgatt 420 gttgtataca ctgaattgct ttgcatggtc tcatttgaga taattgatgt aagaatcctg 480 acttttttat 490 <212> Type: DNA <211> Length: 490       SequenceName: # 440       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatcgctaaa atgtccttga gtcccagcag ccccaggcac gaggatcagc tcgaggtcac 60 cagggaaccg gccaggcggc tcttcctttt tggagaggag ccatcaaaac tcgatcagga 120 tgttttggcc gctcttgaat gtgcagacgt cgacccccat cagttcccgg ccgtgcacag 180 atggaagagt gctgtcctgt gctactcacc ctcggacaga cagagttggc ccagtcccgc 240 ggtgaaagga aggttcaagt ctcagctgcc agatctcagt ggccctcaca gctacagtcc 300 ggggagaaac agcgtggctg g 321 <212> Type: DNA <211> Length: 321       SequenceName: # 441       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actgtgccca gtctatatat aatagatttt agaagaaatt tctgccactc agtgactgct 60 ttaaattcta gagacagagg ctgagagaaa cttagtagcc tgcctgcgca tactgcaagt 120 acagactata taacaagttg aaagagaatc accctggtat ataatatttt aaaacatgaa 180 aaaggcatta ctattgttct ggtctaagta ctctaacagg acgatgattt ctaaccctag 240 catcatgaca tgtatatagt gtgttgtaag acatttgcca gctaatagtt acagtactga 300 agcttgtgaa tacgttaatt gagaaaactt taagcaggtt caaagttatc ccatgatagt 360 ggcattctta tt 372 <212> Type: DNA <211> Length: 372       SequenceName: # 442       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggggagga ttcccagcac agaggatctg atgcgaggag cttctgctga ggagctcttg 60 gcgcagtgtt tgtcgagcag tctgctgctg gagaaagaag agaacaagag gtttgaagat 120 cagcttcagc aatggttgtc tgaagactca ggagcattta cggatttaac ttcccttccc 180 ctctatcttc ctcagactct agtgtctctt tctcacacta ttgaacctgt gatgaaaaca 240 tctgtaacta ctagcccaca gagtgacatg atgagggagc aactgcagct gtcagaggcg 300 acaggaacgt gtctaggcga acgactaaag cacctggaaa ggctgatccg gagttcaagg 360 gaagaggaag ttgcctctga gctccatctc tctgcgctgc tagacatggt ggacatttga 420 gcagcctgac ctgtggggag ggggtctctc ccgaagagtt tctgttt 467 <212> Type: DNA <211> Length: 467       SequenceName: # 443       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttatttgtcc tgaccttttc agtcctacag agacgcatct gtggttcttt tgtacttgcc 60 atagatgtaa cctaaaaagt tttggcatat ttaggtcagc ctagcggaac tttttttttc 120 atttaaatgg agctgaataa tggagatttt gtgtctgcaa aattcctgag atcattgaaa 180 aagtaacaag ctgttccttg tttctgatac ataaaattat tttaagcatt ttatcaatca 240 ttaaaattta ctgccagttg tgagtggctt tttaattaac ttgtctttca ttgcacttca 300 ctctgcctgt tttcaagggg agtaagattg gtaacatttg gggagactgt atctg 355 <212> Type: DNA <211> Length: 355       SequenceName: # 444       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgtccgcctt tggtgaatct ggcagcactg atggaagcag cgatgaggaa ctgagcgggg 60 accaggaggc cagtgggggt ggctctgggg ggctcgagcc cttggagggc agcagcgtgg 120 ccacccntgg gccacctgtc gagagggctt cctgctacaa ctccgcgttg ggctgctgct 180 ctgatgggaa gacgccctcg ctggacgcag agggctccaa ctgccccgcc accaaggtgt 240 tccagggcgt cctggagctg gagggcgtcg agggccagga gctgttctac acgcccgaga 300 tggctgaccc caagtcagaa ctgttcgggg agacagccag gagcattgag agcaccctgg 360 acgacctctt ccggaattca gacgtcaaga aggatttncg gagtgtccgc ttgcgggacc 420 tggggcccgg caaatccgtc cgcgccattg tggatgtgca ctttgacccc acc 473 <212> Type: DNA <211> Length: 473       SequenceName: # 445       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagctcactg tgggatgggg ttgacctctg ccgcctgcct gggtatctgg gcctggccat 60 ggctgtgttc ttcatgtgtt gattttattt gacccctgga gtggtgggtc tcatctttcc 120 catctcgcct gagagcggct gagggctgcc tcactgcaaa tcctccccac agcgtcagtg 180 aaagtcgtcc ttgtctcaga atgaccaggg gccagccagt gtctgaccaa ggtcaagggg 240 caggtgcaga ggtggcaggg atggctccga agccagaaat gccttaaact gcaacgtccn 300 gtnccttccc cacccccatc ccatccccac ccccagcccc agcccagtcc tcctaggagc 360 aggacccgat gaagcgggcg gcggtggggc tgggtgccgt gttactaact ctagtatgtt 420 tctgtgtcaa tcgctgtg 438 <212> Type: DNA <211> Length: 438       SequenceName: # 446       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggattcact actggcacat taacaagcac caataggttt ttattccaac tccgagcact 60 gtggttgagt aacatcacct caatttttta ttatccttaa agatattgca ttttcatatt 120 ctttatttat aaaggatcaa tgctgctgta aatacaggta tttttaattt taaaatttca 180 ttccaccacc atcagatgca gttccctatt ttgtttaatg aagggatata taagctttct 240 aatggtgtct tcagaaattt ataaaatgta aatactgatt tgactggtct ttaagatgtg 300 tttaactgtg aggctattta acgaatagtg tggatgtgat ttgtcatcca gtattaagtt 360 cttagtcatt gatttttgtg tttaaaaaaa aataggaaag agggaaactg cagctttcat 420 tacagattcc ttgattggta agctctccaa atgatgagtt ctagtaaact ctgatttttg 480 cctctggata gtagatctcg agcgtttatc tcgggcttta atttgcta 528 <212> Type: DNA <211> Length: 528       SequenceName: # 447       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaaatatct taccaggcag cctatgaatt aacccaaaga agctttggtt ggttttggtg 60 gatttttatc atgccatgtt ggacatgaga ttttttagat cttccttccc acattgctag 120 acgtctcact caaagacatt tgttgggagt cacatttgca tcataganga gacagtccat 180 tcatcttagt taaattggat tgagaatgcc ttttgtttcc aggaaaatat tgatcaccat 240 gaaagaagaa tagttttttg tccccagaga cattcattta gttgatataa tcctaccaga 300 aggaaagcac taagaaacac tcgtttgttg tttttaaagg caacagactt aaagttgtcc 360 tcagccaagg 370 <212> Type: DNA <211> Length: 370       SequenceName: # 448       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaaggtacg ataatcccac accatatctt ggatttcttg gaaattgact caactctcca 60 ttctaataac atctccattc tccaggaact gtacgaaagg tgctggagcc acagtaacga 120 ggagtccttc agcccctgct ccttggcctg gctttacctg cacttgcggc ttctctgggg 180 tgctatcctg cactcagccc tgatctactt tctgggaacc tttctgctat ccatattgat 240 cgcctggact gtgcagtatt tccagtctgt ctcagcaagc gatccccctc caagaccatc 300 ccaggcctcc ccagacactg ccacgtccac tgcaagtcca gctgtgactc cagctgcaga 360 tgcctctgac caagaccagc ccacagtaac taataacccg gagccacgtg ggtgaactgt 420 gcactccag 429 <212> Type: DNA <211> Length: 429       SequenceName: # 449       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttacctacc tgtgtagccg aagtagtgtg cagtgaggcg tttctgaata catggtcaga 60 tttttggaaa aaaacaaaaa caaaaaaaac aagtaaagtt caaaaaccgt caaatgagaa 120 aattgcaagt agtgtgacag agctgattga ttttgttgct ttcttgattt tttttttnca 180 aaatgggttt actaaaatgt agatgactta actgcctcct ccttcgtctg aaaaatgcca 240 atattcaatc atcatgcagc attataacaa gccttataag tcctaaagca ttaagttgca 300 cttttttgag gaggggtagt gcagtatttc tctggccagt atgaatgaag tttatactta 360 ccatatttga tagaaacata gatcaagcta tggcacagcg actcatcaga tagctagctt 420 tgacgtctgg gcacaattga accaacttcc atc 453 <212> Type: DNA <211> Length: 453       SequenceName: # 450       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcacgggta tgtcctcaat aacctcaagg aaaataaact tcaaaaatta agatccttgg 60 ccaggcacgg tggcttatgt gtgtaatccc agcacttggg gaggctgagg gaggtggatc 120 acttgagtcc aggagtttga gaccagtctg ggcaacatgg cgaaacttca tcactaccaa 180 agaagaaaaa aaattagcca ggtgtggtgg tgtatgcctg tagtcccaga tactctggtg 240 gctgaggtga gaggatagct tgagcccagg aaattgaggc tgcagtgaac tatgattgca 300 ctactgtgct ccagcttggg caacagagtg agatcttgtc tccaaaagtc cttgaaggat 360 tttaggaagt tgttaaaagt cttgaaacga tgtttggggg catgttaggg ttcttgaatg 420 tttaattcct ctaataactg cttattcaag agaagcattt ctgactgggt gcaggg 476 <212> Type: DNA <211> Length: 476       SequenceName: # 451       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttaccacgtg gtcatctttt acaaacccat aaacattttg attagctgtg tgtgtgttga 60 aaaactgtaa atatgtncag tagcgataaa actaaaataa ctttgatttg ttgataagtt 120 cctaaaatgt ggaggtggat taaaacctta ggagaatagc agaaatcaaa cttcatgaaa 180 agttattttg gggctttcct gtgaaatgta tgaacaaaga ggctcagaga aggacatgga 240 agacaataat gtatactctc tcctcctccc tgaataatga aaaccatgtg tatttgttcc 300 ctccgtatgt taaagatttc cttttagtgg tacattctgc actcattttg tatagtctac 360 caaggcgggt atccctagga acaatattat ataggaagca ggtatactct gatcacattc 420 aggataagtg tacagaagaa aatacggtgt ttactcttta gggaactgga aacactccct 480 gcattgatgt aca 493 <212> Type: DNA <211> Length: 493       SequenceName: # 452       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagatttacc atgtatcagt gcctggcttt ttgttataaa gctttgtttg tctagtgctc 60 ttttgctata aaatagactg tagtacaccc tagtaggaaa aaaaaaaaac taaatttaaa 120 aataaaaaat atatttggct tatttttcgc aggagcaatc cttttatacc atgaatatt 179 <212> Type: DNA <211> Length: 179       SequenceName: # 453       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtttatacaa ctgtcagtcc acccagtggt gcaactggtt ctgattcagt cttccgatnc 60 ctttttattt ttcacttttt cctatttctg aatttttttt ttnatttgtg atcttgattt 120 tgatgagggg ttggggagtg gggagggagt cgaaccaaga cttggagtta agaggatttt 180 catcttttgc atccaacagg cagaatatga tctgtgtcca aaagtgaact tgagtcagga 240 atgaatcaat ttcagcataa acaagcacaa aaatttagtc tgctggctga ctggaagcaa 300 aaaagtcaag atggaatatg atgaattcca acacaatggg gcaccaaggc ctttaggcct 360 ctctttttat tttgctttgg ttttgtttgt ttttctttag agacatgctc tttctcatgg 420 gacttgaagt ggactcatct ttgtgcagtg ctggttttgc catactcatt tcaagtatta 480 tagacatatg taatggtgaa aatatatgaa ctgtggcctt tttcattctt gttacttgtg 540 <212> Type: DNA <211> Length: 540       SequenceName: # 454       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: catacccata ttttaaggga caggtgaatt tactactttc taaagtttat tgatacttcc 60 cttttatgta aaatgtagta gtgataccta tatttccaca ttgtgcattg tgacacactt 120 gtctagggat gcctggaagt gtataaaatt ggactgcatt tcttagagtg ttttactata 180 gatcagtctc atgggccatc tcttcctcag atgtaaatga ta 222 <212> Type: DNA <211> Length: 222       SequenceName: # 455       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagcgatcc aaattctgag tctttatatt ttgaggatga agatgggttt caagaactaa 60 atgagaatgg aaatgctaag gatgagaata ttcaacaaaa actttcttct aaagtattgg 120 atgatttacc tgaaaactca ccaatcaata tagttcagac tccaattcct attaccacct 180 cagttcccaa acgtgcaaaa agtcagaaga agaaagcttt agcagcagcc cttgccacag 240 ctcaagagta ttcagaaata agtatggagc aaaaaaaatt acaggaagct ttatcaaaag 300 cagctggaaa aaagaataaa acacctgtgc agctagattt aggggacatg ttagctgctc 360 tggaaaaaca acagcaagca atgaaagcac ggcaaattac taacaccaga cctctgtcat 420 atacagtggt tactgcagct tcttttcaca ctaaagactc tactaataga aaacctttaa 480 ccaaaagtca gccctgtttg acatccttta attctgtgga cattgcttct tct 533 <212> Type: DNA <211> Length: 533       SequenceName: # 456       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caagagctac aatgtcacct ccgtcctgtt taggaaaaag aagtgtgact actggatcag 60 gacttttgtt ccaggttgcc agcccggcga gttcacgctg ggcaacatta agagttaccc 120 tggattaacg agttacctcg tccgagtggt gagcaccaac tacaaccagc atgctatggt 180 gttcttcaag aaagtttctc aaaacaggga gtacttcaag atcaccctct acgggagaac 240 caaggagctg acttcggaac taaaggagaa cttcatccgc ttctccaaat ctctgggcct 300 ccctgaaaac cacatcgtct tccctgtccc aatcgaccag tgtatcgacg gctgagtgca 360 caggtgccgc cagntgccgc accagcccga acaccattga ggga 404 <212> Type: DNA <211> Length: 404       SequenceName: # 457       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggctcact ttgcagttgg cactgggttg gggaggaaga gagctgatga gtgtggcttc 60 cctgagctgg ggtttccctg cttgtccagt tgtgagctgt cctcggtgtt accgaggctg 120 tgcctagaga gtggagattt ttgatgaaag gtgtgctcgc tctctgcgtt ctatcttctc 180 tctcctcctt gttcctgcaa accacaagat aaaggtagtg gtgtgtctcg accccatcag 240 cctctcaccc actcccagac acacacaagt cctcaaaagt ttcagctccg tgtgtgagat 300 gtgcaggttt tttctagggg gtagggggag actaaaatcg aatataactt aaaatgaaag 360 tatacttttt ataatttttc tttttaaaac ttggtgaaat tatttcagat acatatttta 420 gtgtcaaggc agattagtta tttagccacc aaaaaaaagt attgtgtaca atttggggcc 480 tcaaatttga ctctgcctca aaaaaaagaa atatatccta tgcagagtta cagtcacaaa 540 gttgtgtatt ttatgttaca ataaagcctt cctctga 577 <212> Type: DNA <211> Length: 577       SequenceName: # 458       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccacatgct ggaagcctga ggcctccctg gactgagcct gtggcactgc gtgcgggaca 60 ngttatgttt ccttgccccg tcgcattaat gaggcccttc cacatcattt ttaaactaat 120 gtttttctat attaacatta ttatggatat ttggctttca taggccacac acaggtgtgc 180 tgcgcgggaa gccccatgct ccaatcaaag ggatttttag tagtgcctct aagcaagcac 240 cgatgagtca gtcccacgta ttttcttttt tgtcagtatt gtttgggaag gagacatgcc 300 gggatgtgtc atcgtgccaa ataccacatt tcctgttggc acagtttcac agaagtaaac 360 ataagcatgt tttaacaggt ttttcttttc ttttttcttt tttaaaatgt tttatttatt 420 taacccgcca ttgtgtgttt ttaagtattt tcttttttta aggaaaggaa aagcttgtca 480 caatctaact ggctatg 497 <212> Type: DNA <211> Length: 497       SequenceName: # 459       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgctctttg acactgcttt tggtaccctg ggtggcctat ttcaggtggt ttttagtgtc 60 tgcaagcgga ttggctacaa ggttactttt gacaattctg gggagttata aactcaaaaa 120 actaatagta tccagtcaca gtgaatttga aagctggaat agtttgtctt tacaatgggt 180 ttctgttcac tgtcagttat cattatattt tggcctttgg tggggatgtc tgcttgtttt 240 tgcaaaagaa gatggcagaa tttagacttg acagaggaga aatgctcagg gtgagattag 300 gtgtagtaat ctgctgttta cctccagtta tatgtgcaaa ctcccaagcc actaataact 360 tcagttatgc actctaacac agacgaccac ctgaaatgca ctggtattta tttctgataa 420 ttaaaaatta caggggaggg aagaactaga aaaagaacaa ctttagacca aaggtgtctg 480 agaaaaggag aaagggagct tgttcttccc attgc 515 <212> Type: DNA <211> Length: 515       SequenceName: # 460       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tctatctctg cataacacgt tccaacacag cagtagtggc ctacagtctg tgtcatcttt 60 gggtcacagc agtgccactt ctgcatcttn gccttttatg ccatttgtga tgggtggtgc 120 accatcatcc cctcatgtag actccagcac catgcttcat caccaccacc accaccccca 180 cccccaccat caccaccatc accatccagg cttgagagcc cctggctacc cctcttcacc 240 agtgactacc gcctctggta ctaccttgcg gttgccacca ctgcaacctg aggaggatga 300 cgatgaggat gaagaagatg atgatgactt atctcagggc tatgatagct cagaaaggga 360 cttctcactc attgatgatc ctatgatgcc agctaactca gactccagtg aagatgctga 420 tgactgaagc cccagcatgg gccccattgc ttgggcggct gctgtatttt catttactct 480 ggcccttgga ctatggaaac gtgggagggg caggggagat gtggggaagt ccaggactcc 540 <212> Type: DNA <211> Length: 540       SequenceName: # 461       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taaagatctt gctgtggctc tgttatgttc tgaggccttg ggattagcct cttcctcatt 60 anggagctga ttttctagtc tgtggatcag ctatgccttt ggacacttct cttttccatt 120 gtgccttttg aatgttgtct tctcactcag catcagcact tcgatctaaa tgcagactag 180 gnagttggga ggaggaacca aagtgaacca tccttcattt attcagtcat tcgttcatct 240 gtcaaacacg tatttggaca tcaaggttgc agagatgaac aatgcatgga tttcatcttt 300 gaggagttca aaacctagtg gagagaacac atggtacaat cgtaacacat gaaggacaag 360 taagtgctgc agtaaaggta ctaataacat gttccttgga acagaggaag aaaaaccacg 420 aaaccatgga aattagggaa gcctttacag agggtgtgac 460 <212> Type: DNA <211> Length: 460       SequenceName: # 462       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtccccaatc aggaatcgcg gttcggggct cggcgccgca nnnnncnnnn nnnnnnnnnn 60 nnnnnnnnnn nngnnnnnnn gannnanncg ccnacatggg ccgcgttcgc accaaaaccg 120 tgaagaaggc ggcccgggtc atcatagaaa agtactacac gcgcctggng caacgacttc 180 cacacgaanc aagncgcgnt gtgcgaggag atcgccnatt atccccagca aaaagctccg 240 caacaagata gcaggttatg tcacgcatct gatgaagcga attcagagag gcccagtaag 300 aggtatctcc atcaagctgc aggaggangg agangagaaa ggagagacaa nttatgttcc 360 tgaggtctca gccttggatc aggagattat tgaagtagat cctgacacta aggaaatgct 420 gaagcttttg gacttcggca gtctgtccaa ccttcaggtc actcagccta cagttgggat 480 gaatttcaaa acgcctcggg ga 502 <212> Type: DNA <211> Length: 502       SequenceName: # 463       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcagagtgg catcagccaa ggctggttag gctgagccag gattngtcat cagctaaata 60 ggaggactct gccaaatcaa tctgggcaag aagcaggatc ctgagtctgg gcaatgagag 120 tcagagaact taactcctgt gtgcagggta gaattttccc atggcagaaa ttctgagttt 180 tctgccttat ttttcttggg ataaccagcc acanggagac cttcaggtaa aatgtggttc 240 aaatatggga aggcagaggt acctgggacc ttgctactca agtatgattt gtgaaccaac 300 agcatcaaca tcgtattgaa gtttgttatt tatagaaatg cagaagtttg ggctctgctc 360 caaacctatt aaatctaaat ctacattgca acaaagtccc caggtgattc acaggcactt 420 tgtagtttga gaagcactgt actaagatta ctgtgttgtc ttcacatgaa tgaggctata 480 atgtagaatt accagtgaat gtgactaatg ttttctgaca agggacctct gcttacaagg 540 tccctgggca tggtgcc 557 <212> Type: DNA <211> Length: 557       SequenceName: # 464       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccagccgtg acatgaagca gaccatcatg gagaccctgg agcagggccc agcacaggcc 60 agccccagct acgtgcccct cttcaaggac attgtggtgc ccagcctgaa cgtggccaag 120 ctgctcaagt agcctccgcc ggcctgccct gctcgcccct ccacagcctc ggtccctgcc 180 tttagaaacg cgggacagct gattgctctc cttggccaca cgtgctcctt ttagctgcac 240 ggcctgtctt taggtgccag tgtgatgcac cgggtgtgcg tcgagtgagc gtcccgaggc 300 cacgtgcgga ggcccctcac tgtgctgtca aaggcctgtg ggtgcanggc tctgccgcac 360 agcctctctt gggtgcttgt ttgttgcagt ggttgaaagt gtgtggggca cagaggacgt 420 gcacctccct gccctcctcc tccctgggcc ttcaccgcac cccatctgct taagtgctcg 480 gaac 484 <212> Type: DNA <211> Length: 484       SequenceName: # 465       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaaaccgca cctttaactt tgcagacctt ccttcacccc tgacttctgc ttcacctttg 60 acctctgccc cccatgaatc ccattttacc tctagaccta taagttctgg tttatgtttg 120 accnccnccc nncngngntg cacttcaccg ctgaccttgc ctcaccttta accccccacc 180 tgagccccag ctcctacctc tgaccccaac ttctctttga tctctgaatc ccctctgact 240 ccaacttctc tttcaccctc tatgagtccc attttacttc tacacctgca agtcctggtt 300 tatattggna cccctccctc cgagctgcag ttcacctntt gaccttgcct caccntttca 360 ccccccaccc cnnnnnngng nnngctccta cctctgaccc cagcttctct ctgnttccca 420 caggccccat gcatcctccc tgcctcactc ccctcagccc ctgccgacct tagcttatct 480 gggagagaaa caaggcctgg t 501 <212> Type: DNA <211> Length: 501       SequenceName: # 466       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtaggaccaa gtgatgacac ccctcgaagg ggcccagagt ccctgcccgt gggacatcat 60 gacatcatca ctgatgtcgc cacattccag accacacagg gcttcatcgt aactgcttct 120 agagatggga ttgtgaaggt gtggaaataa aacctactga tttgtataaa ttttaatagt 180 tataaatata atactataac tcgagaaaag gcatttctag agaacagatt catttgctta 240 attttcaaaa ttatgtctcc atattactgt ttcatgactg actgactaaa tgacacccaa 300 aatggttaag atgtacttga ctagtttact tatgcatctc tttgcaagaa tcagccagcc 360 a 361 <212> Type: DNA <211> Length: 361       SequenceName: # 467       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttatctgca caaacatctc cacttttggg ggaaaggtgg gtagattcca gttccctgga 60 ctaccttcag gaggcacgag agctgggaga agaggcaaag ctacaggttt acttgggagc 120 cagctgagaa gagagcagac tcacaggtgc tggtgcttgg atttagccag gctcctccga 180 gcacctcatg catgtcccag cccctgggcc ctagcccttt cctgccctgc agtctgcagt 240 gccagcacgc aaatcccttc accacagggt ttcgttttgc tggcttgaag acaaatggtc 300 ttagaattca ttgagaccca tagcttcata tggctgctcc agccccactt cttagcattc 360 ttactcctct tctggggcta atgtcagcat ctatagacaa tagactatta aaaaatcacc 420 ttttaaacaa gaaacggaag gcatttgatg cagaattttt gcatgacaac atagaaataa 480 tttaaaaata gtgtttgttc tgaatgttgg tagacccttc atagctttgt tac 533 <212> Type: DNA <211> Length: 533       SequenceName: # 468       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctctcttaac atccaagcct tttaatgaaa tcgtactgaa atctgtatca gctaagagtc 60 ctccaatcct ggntcccatt aactccaagt gcctttttga cagtgacaac agacagtccc 120 tcgctttttg ttgttgttgg ttttcttaac ccctttaatg gaactgcctg gattttatac 180 agttattaaa ggatgtctct tttgctttaa actgcatgct gccaagtgcc atttggggtc 240 agcatcctcg tttcaacaca gtgtgctctc tagttatcat gtgtaacgtg ggttctgttt 300 agcgaagata gactagagga cacgttagag atgcccttcc ctgctccatc cctgtggcac 360 cattatggtt ttttggctgt ttgtatatac ggttacgtat taactctgga atcctatggg 420 ctcatcttgc tcacccaatg tgggagtctg gtttgagcaa gcgagc 466 <212> Type: DNA <211> Length: 466       SequenceName: # 469       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcattgtccc tatgtaacta tcttaatggc tatatatatg tattttataa agccatttat 60 gtatacacat gtaacttgga atttccttca tccctacaca ttttctacac ttacatcacc 120 ttattgcata aaacaaagtc acgcgctttc tgcttgaaca tcaaaatatc aaaaaccaag 180 gtacccaaaa gatacaagtc agagacaaca tccttgtcca tatccaaacc cagtgtttca 240 gtgctagcaa cttaatttct catacattta tagagtttgg tttgctttgc tagttgtgtg 300 aatcattggg ctgtttttag agccactgtt aagagagaat ataaaataat catgacaatt 360 actactgttt ccacatttac aaattgtgta cttaaatgaa cctcatttcc cttttatttc 420 tgaatggctt gtctgag 437 <212> Type: DNA <211> Length: 437       SequenceName: # 470       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatatgggac ccagtgccag gagctggaag acaaggtgtt tctgccaaac ggggacctcc 60 atccagagaa aaggaagaag gtgcagggtg ggccaagagg caagtgaagg ttggcctgag 120 tctgggccgg aaactcagag gatgtttctc ctctgctggg agctgtagtt tcttatcaaa 180 atagatattg ttccaccatc cccctccttg gcccttcaag tgggctgaag cccttggaaa 240 gtgacatagg aagtccccag atcttgccct tctcactcca gaggctagtg gtcacagaca 300 gctgggaatg gcagccacag agggtcccct ctgggagaaa cagcttcacc ccagcctcag 360 ggccctgggc catcactgca gtggccctgg gaggtgagga agaagctggc tagaggaggg 420 ggctcccacc taccttttat ttaagccagt attctttgtt cctgct 466 <212> Type: DNA <211> Length: 466       SequenceName: # 471       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggagagtatg gcggctggta caaagcctgc aaagttgata gtccaactgt tacaaccact 60 ctaaaaaacc ttggggcact ttacagacgt caaggcaaat ttgaagctgc agaaacgtta 120 gaagaagctg nnntgnnnnc tcnnnaacag agggtggcag aagtgctcaa tgaccctgag 180 aacatggaga agcgcaggag ccgtgagagc ctcaacgtgg acgtggtcaa gtacgagagt 240 ggccctgacg gaggggagga a 261 <212> Type: DNA <211> Length: 261       SequenceName: # 472       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtcatacagt gtttcacgtc tctgaaattg ggattataat agcactattt tgatgtagct 60 ctaccgatac tatgtggtaa tgctattttg ttttactaac aagctctgga atatttagca 120 gtcattttca ctggcacaag agccttttgt atgttattca atttaaactt ttaaaccaaa 180 aattttatgg tccagtgtct ttggcaaaaa gatgctggag ggaatgtaac atacaattaa 240 tatgtggtta tatatatata taaaaagaca caaattgcca tgttatggtt ctgccttgaa 300 acagcacaat gaagtgtatc agtatattct gtgattatga aacttatatg ttgtgttgtt 360 ttgtgtcttc tgttgcctgt cctttgggcc agatgtgggc cagttaaatg cagttatcat 420 ctcattaaat acagatgcag ataaaatatc tttagtgctg caacatttta cctaactttt 480 tgtatgtttt catgactgtg tgttattttc caaagctgtt cctacctcac catgaggctt 540 t 541 <212> Type: DNA <211> Length: 541       SequenceName: # 473       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cttgatttgg tgaatacagt tatattttaa aaccttaagg tgacaagcat tttctatgcc 60 taaatcttca ttggtttgcc tggaaagagt ctctgttaaa agattttcca tattcaaagt 120 aaaaggaaag atttcttgct ttctaattgt cttttggaca catgcctatt ttctttgagg 180 tataaacctt tagatgtgaa aaatgtaatt tcattctgct attgtgtgtg cttgtgtgtg 240 tgtaattgaa aaaactggga aatcctgctt tgttggtaat aaatc 285 <212> Type: DNA <211> Length: 285       SequenceName: # 474       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctacctcac cttgctattt attgctgtaa tttattgacc tcaaaaatgc tgcataacag 60 acctcactgg ggcagggagg atccccaggg ctcccaccct ccacttggcg ggccccgtgg 120 ggccaggtgc tgaggggagc ctctctnccc cacccatcac tagcttccct ctgccctctc 180 ccaccccggg ggggacccag gttgggcact ggctcatttc tcgcaaatac ctcgaagggg 240 aggggggagg gatggggtta tagctgtttt gtttaattgg aactggaaga gggatcatgt 300 tttgttttat gcccttccca gaagggggga gggacaccgg gatcgcactc ctgtactggc 360 caccgccgct gtcacttgtc acattgagtt catgtccctt gagagtttgt ataaattcag 420 gtcagagctg cagctacaca gctgcccagt gtcatagaaa agcaattcac caacgactga 480 tctctccatt cagaagtgtg cagtcttaaa tgtacagcga 520 <212> Type: DNA <211> Length: 520       SequenceName: # 475       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgttacctc ttaggggaag ttatgccccc tcaactattg tcttattata atgaatcttt 60 cctttttggt ccttttaagt aaccactcaa aacttttcat ttcactgaaa aaatatgaaa 120 aaccatgaca atagggctgg gtgcagtggc tcacgcctgt aatcttagca ctttgggaga 180 ccaaggcagg cggatcgttt gaggccagga gtttgagacc agcctgggca atgtagcaag 240 actctgtctc tgcaaaaaaa attaaaagat acctgagagc tcnctttaat atcaaggtat 300 ttgcatccat tcccaccctg ttagctctta agggaggagg gaaatcaatt ccaaccatac 360 tttcctgtga tggaagatgt ttcctcttga aaaaatgcca atacagattt ttaaaaccta 420 ttgttttcca aatgcacttt gtaagttttt gcttttaaaa tagcttcttg gaaccaattt 480 tattgtattt gtacttaatt tttgttctca tctaaatgtg cattttctga ctgtatagaa 540 gaagctttgg tatgtaattt aa 562 <212> Type: DNA <211> Length: 562       SequenceName: # 476       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggtcttct ccatgactag tggtctggat aggagttttg tgtccagaaa attttatgta 60 atttattttt ttaaangaac ctgttgtaca tctttctcna atacaaactt gggctttagc 120 tgccccctcc actaaaccga tgacttactt ttttgactag aatgagaaaa tggcaagaat 180 cttagtaagg tggtagccag cttggtaact gcatagtaat cgagaggctg taagatggga 240 attcatcgta ggcagcgagg tagagtgggt cccctgaaat gggattcgct tggcactgcc 300 tcttaaagat aggggtgttg ggatcttgat tgtggccgcc ccccccagct ttacctgccc 360 actttgtcct tcttggcaag cctgttcaca tggacgtcca gagccagtgg acagagagga 420 ggggacggac agcagaggtg ctgcttttgc agcagaaact ttgttgcagt tcagagtata 480 ccttctgctc tgctccagag caagagttgc aaaccaggcc cttggggctg gccatttgtt 540 tttgta 546 <212> Type: DNA <211> Length: 546       SequenceName: # 477       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctaatgatg acttgagccc tgccactcaa tgggagaatc agcagaacct gtaggatctt 60 atttggaatt gacattctct attgtaattt tgtncctgtt tatttttnnn ttttnttttt 120 ntttcactgg aaaggaaaga tgatgctcag ttttaaacgt taaaagtgta caagttgctt 180 tgttacaata aaactaaatg tgtacacaaa ggatttgatg cttttctctc agcataggta 240 tgcttactat gaccttccaa gtttgacttg tataacatca ctgtcaaact ttgtcaccct 300 aacttcgtat tttttgatac gcactttgca ggatgacctc agggctatgt ggattgagta 360 atgggatttg aatcaatgta ttaatatctc catagctggg aaacgtgggt tcaatttgcc 420 attggtttct gaaagtattc acatcatttg ggataccaga tagctcaata ctctctgagt 480 acattgtgcc cttgattttt atctccaa 508 <212> Type: DNA <211> Length: 508       SequenceName: # 478       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcattgctg tcaacattaa gactgcagag atttacagag cntcctttca agatcggggt 60 ccggangagc agcttcgtgc tgcgcgaact ttagcaggag gaccaatgat tagcatttat 120 gatgcagaga cagaacaact tcgtatagga ccgtactcct ggacaccatt tccacatgtg 180 gatttctggt tgcaccaaga tgacaagcaa atactagaga atctttccac ttcgcctctg 240 gctgagccac cccactttgt tgaacatatt agatctacct tg 282 <212> Type: DNA <211> Length: 282       SequenceName: # 479       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggaaataa agccctactc tacaaaaaaa atgaagatgg cttgtgggaa aagatctctt 60 ctccaggaag ttaaaaaaca tgaattacca aagaaagcac cttcttggcc tgacagacca 120 ttggtggggc tggcacgaat ccagatctgg atcctacatc tgttgggtct taggcctcct 180 tccctcctca gtgtctttca aatgactttc atc 213 <212> Type: DNA <211> Length: 213       SequenceName: # 480       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tagaaaactt aaatcctgtc acaggatatt tagacatgtg tagaatgtag ctcaattttt 60 aaaaagtaac tgacctagag ggtgaaagtt gaaactgaca cattttcaaa ttaagattat 120 gcttattttg tacagaaaac aatgtttaaa cacaagcaga tctgttgtat gtaataagta 180 acacagagtt ttaaaacaaa ttaattattt agctttattg aagtttgttt ttttccttcc 240 gaacctggag tatcatatta taaacagcag tttcacacca gaatagcagt gccctttctt 300 tttgtacata ctgattggac ctttctttac tgttacgtgg acactttcta tgttagtttt 360 gatgcataat tctttgaatc cttttataca aactagaatg tatgtgtaag aatacctgtc 420 cctgcaatgt agtaacta 438 <212> Type: DNA <211> Length: 438       SequenceName: # 481       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaagccagc agagttgtct taaattagtg gtggatagaa gacttagaat agaaactttt 60 agtattaccg atggggaaaa aaaaactact gttaacactg ctaatgaaag aaaatgccct 120 ttaactttct aatgattata gataaatata atatgcgtct ttttcacaat atcctatgat 180 ttttagacta ggctctagtg ttcagaattc atgaaattat ccatggtaaa aactagttat 240 aaaaattaca taattcaaag ataacattgt tattcttaag ccttatataa tattgtaact 300 tgcatgtatc catacctgga tttgggatga aatacttaat gatctttcca ttggaaataa 360 ctggaagtga agaggttttg ttgcttgtac agtgtcagat gaggaacacc actatcttaa 420 ttttgcgata cactgcattt gctggtgcta tttttataca gtgaagcaac agctttgcag 480 ca 482 <212> Type: DNA <211> Length: 482       SequenceName: # 482       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaataaacca tatcgcccaa ttccagtgac atgggtacct cctcctggaa tgcattgtga 60 ccggaatcac tggattaatc ctcacatgtt agcacctcac taacttcgtt tttgattgtg 120 ttggtgtcat gttgagaaaa aggtagaata aaccttacta cacattaaaa gttaaaagtt 180 cttactaata gtagtgaagt tagatgggcc aaaccatcaa acttattttt atagaagtta 240 ttgagaataa tctttcttaa aaaatatatg cactttagat attgatatag tttgagaaat 300 tttattaaag ttagtcaagt gcctaagttt ttaatattgg acttgagtat ttatatattg 360 tgcatcaact ctgttggata cgagaacact gtagaagtgg acgatttgtt ctagcacctt 420 tgagaattta cttta 435 <212> Type: DNA <211> Length: 435       SequenceName: # 483       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcctgggccg ttacatctgt gcagggctgg tttgttctga ctttttgttt ctttgtgttt 60 gcttggtgct ggtttatttg ttgttttctg ggggaaaaag ccatatcatg ctaaaattct 120 atagagatag atattgtcct aagtgtcaag tcctgactgg gctgggtttg ctgtcttggg 180 gtcccactgc tcgaaatggc ccctgtcttc ggccgagctg gtttcctgcc cagcctgggg 240 caaacctagc cggaaggccg aggtcccatt gttggcgctg aggtgtctgg cctgaggtca 300 atggtgcaaa ggagccgcca ccgggcatgt ctgcctggag tgctgtgctg tgtttaatca 360 ggggatacag gcccctgggt ttcttttttc tttcttcctt tcttccttgg ccaagagaag 420 ggcttacagg catggacatg caggttggca aacgggcttg actttggctg atttaaaaag 480 tgagaaagaa agtaaaaaag gttaattttt ccttcctctg taagatatcc cag 533 <212> Type: DNA <211> Length: 533       SequenceName: # 484       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaggtcttac attgcctgac taaaatgttt catttacctc taaatttcca tatccttctg 60 gctgtagata aataatgtag ttttgtttat gcatttggaa ttagtggatt tttttgtcat 120 taaaattgtt accactggta acatgtgaca agcacaccac aattctccct atcttgtgaa 180 gttgtttttt taaatcgcct tgaacaaaaa gntttttttt ttgtttgttt ttgctttctg 240 aaattcacag aagcctagga ggactggggt aagcggaata aactagagaa gggagacatt 300 gtttggattt cctttatact gtgaagttac atgcataaaa gggtcaaacc tgtagatgca 360 gaaaaagaaa aaaanctata aatacaaatc tgtataaatg tctattatta tgaagaattg 420 ccaatcttgt tttaagcaaa tgcattctat cgttattata aatgttagtt ctagctctat 480 ttacttctaa tcttaaatca gaataaatta atattgtatt gctgctgtgc gtgga 535 <212> Type: DNA <211> Length: 535       SequenceName: # 485       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgccactga tgcacagcca ggcaacacct taagtcctgc caacaattca cactccagaa 60 aggcagaagt gatttacaga gtccaaattg tggatcccag tcaaattctg gaagggatca 120 acctgtctaa aaggaaagag ctacagtggc ctgatgaagg aatccggtta aaagctggga 180 gaaatagctg gaaagactgg agtccgcagg agggcatgga aggccatgtg attcaccgat 240 gggtgccttg cagcagagat ccaggtacca gatcccacat cgacaaggca gtgcttctgg 300 tccagattga tgataaatat gtgactgtaa ttgaaactgg ggtactagaa cttggggctg 360 aagtgtgagc cagtgtttat tataaagaca tttctttttc cctctcaatt ccaaggcatt 420 ggaaaaagag aggaacaagc agaagatgcc tgcaggtatc actttgatcc 470 <212> Type: DNA <211> Length: 470       SequenceName: # 486       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggaggccct tatgagggca gcccagcccc cgcacccacc cccnancaga gaagcacaga 60 tcttggggag ctgccccaca agccccgctg gccaccgagg gctgcagncg ctgcgctgcc 120 ggcttctccc caccaccctg ccacctccac tgtgatgtat gtccgctccc tcgtctgttc 180 ccccaggatc tcgaagtgac tccgggctga gcagtggggc ggctggggga ggggtgacga 240 ttctcctcag gctttggccc tgcaagcaaa cccacatatc tgctctgtat gtaataaatg 300 <212> Type: DNA <211> Length: 300       SequenceName: # 487       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctttgtgtat agacaagccc atgcccatta aaataaagtt atcctgtaac ataaatttta 60 ttaaataata cttccccaca gatgagaggc acgcaacacc tatggacaaa agggagttac 120 agaggctgct taaaagatgg agaaaagcct gagattgaag gaggaaaaaa acccagtatt 180 taaagtctat aaaaaatact caaaatagtg ggtcttcgag tttaaaatag tcattgttat 240 tttacattct aaagtgcatg taggttgata ttttttaaaa tatcattgga gaatttaatc 300 tttctttata aaaatagagc atttttctgc tttctggcaa aagttgggga taaaaggaaa 360 aaaagttgtc aaaatgtaat tttcagtcca attcnccagg aaaacatgct tgtgaattgt 420 gcagtaaaag gtggtaatga ctactggaag ctaagtcaaa ggtgatttcc tacctgat 478 <212> Type: DNA <211> Length: 478       SequenceName: # 488       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcccaggga gggaacggac ctgcgagtca cacaactggt gacccacacc agcggctgga 60 gcaggaccct cttggggaga agagcatcct gcccgcagcc agggcccctc atcaaagtcc 120 tcggtgtttt ttaaattatc agaactgccc aggaccacgt ttcccaggcc ctgcccagct 180 gggactcctc ggtccttgcc tcctagtttc tcaggcctgg ccctctcaag gcccaggcac 240 cccaggccgg ttggaggccc cgacttccac tctggagaac cgtccaccct ggaaagaaga 300 gctcagattc ctcttggctc tcggagccgc agggagtgtg tcttcccgcg ccaccctcca 360 ccccccgaaa tgtttctgtt tctaatccca gcctgggcag gaatgtggct ccccggccag 420 gggccaagga gctattttgg ggtctcgttt gcccagggag ggcttg 466 <212> Type: DNA <211> Length: 466       SequenceName: # 489       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaattagtt ctgtccactg tggaggggag aggaaataat gctgtaaatg ttgagttaca 60 gaaagtccaa tgtcaaatat agtttttttg tttcctttca aatgtattac agactgtgcc 120 aaaacagtta ccaattcaca ctgtcaatat taaagtatac catagtatan aaannagtca 180 gtacttgctg ttaattttaa tatttctgat ttaacagtta gttattaagt ggtacttcat 240 tgctgtttta gccaacgttt taaaaataat ttgggagttt gactattttg gcttacgtac 300 tcatttcctt ttctctgcta aaaatgtttt gcttgtgtgc gttcctgatt tttgtcttgt 360 ataatcttga tctttgaaaa ccctcaaaca tgtattaaat tgttgtaact ttttttcatt 420 agagggaaga cattaagggg attggggaca tttgtttcac acatctgcag taatatgagt 480 taactaatat ttaacaagct ctttctt 507 <212> Type: DNA <211> Length: 507       SequenceName: # 490       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccagcggag gccacaagtc ctcctcttcc ggnncnnnnn nnnnnnntnc nnntnngngn 60 ncnagnnnnn nnnnannnnn ccaanatact aacaaaacca gagtaatcaa gacaattatt 120 gaagaggtgg cgcccgacgg tagagttctt tcatctatgg ttgaatcaga aaccaagaaa 180 cactactatt aaactgcatc aagagganag agtctccctt cacacagacc attatttaca 240 gatgcatgga aaacaaagtc tccaagaaaa cacttctgtc ttgatggtct atggaaatag 300 accttgaaaa taaggtgtct acaaggtgtt ttgtggtttc tgtatttctt cttttcactt 360 taccagaaag tgttctttaa tggaaagaaa aacaactttc tgttctcatt tactaatgaa 420 tttcaataaa ctttcttact gatg 444 <212> Type: DNA <211> Length: 444       SequenceName: # 491       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggctgaggg gggaacagcg cggccaggag cccctcgggc ccggcgcctt gcatttcgat 60 ctccgtgatg acgatgacgc ggaagaagaa gggcccaagc gggagcttgg tgtccggcgt 120 cccgggggcg cagggaagga gggcgtccga gtcaacaacc gcttcgagct gataaacatt 180 gacgatcttg aggatgaccc tgtggtgaac ggggagaggt ctggctgtgc gctcacagac 240 gctgtggcac cagggaacaa aggaaggggt cagcgtggaa acacagagag caagacggat 300 ggagatgaca ccgagaca 318 <212> Type: DNA <211> Length: 318       SequenceName: # 492       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtgtgcttc gtgctgtagt tatcgttagt tcctcttccc gagatggggc cgccgagaga 60 ccccagcgcc tttgaaaagc aaggtttgtg ctgcgcttcc agttccgaaa agcagatgtt 120 taagcccttg gactgagggt gggatcgcag ctccgaagac ggagaggagg gaaatggggc 180 cctttcccct ctattgcatc cccctgcccg actccttccc cgcacccacg tgccctagat 240 tcatggcaga aaatgaccaa atcctgtgta tttgttttat atatttaata actgttttaa 300 atgaaagttt tagtaaaaaa aatacaaaac aaaaagatta aattgctatt gctgtagtaa 360 gagaagctct ttgtatctga acatagttgt atttgaaatt tgtggttttt taatttattt 420 aaaattgggg ggagggcatg ggaaggattt aacaccgata tattgttacc gctgaaaatg 480 aactttatga accttttcca agttgatcta tccagtgacg tggcctggtg ggcgtttctt 540 cttgtactta tgtggtttt 559 <212> Type: DNA <211> Length: 559       SequenceName: # 493       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgcacgatg cctggagtta ctgtaaaaga cgtgaaccag caggagttcg tcagagctct 60 ggcagccttc ctcaaaaagt ccgggaagct gaaagtcccc gaatgggtgg ataccgtcaa 120 gctggccaag cacaaagagc ttgctcccta cgatgagaac tggttctaca cgcgagctgc 180 ttccacagcg cggcacctgt acctccgggg tggcgctggg gttggctcca tgaccaagat 240 ctatggggga ngtcagagaa ncggcgtcat gcccagccac ttcanccgag gctccnaaga 300 gtgtgngccc nccnngggtc ctccaagccc tggaggggct gaaaatggtg gaaaaggacc 360 aagatggcgg ccgcaaactg acacctcagg gacaaagaga tctggacaga atcgccggac 420 aggtggcagc tg 432 <212> Type: DNA <211> Length: 432       SequenceName: # 494       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctttgctatg acttctggcc agatgtggaa ccatatccgt ggacctccat atgctcataa 60 gaacccacac aatggacaag tgagctacat tcatgggagc agccaggctc agtttgtggc 120 agaatcacac attattctgg tactgaatgc cgctatcacc atggggatgg ttcttctaaa 180 tgaagcagca acttcgaaag gcgatgttgg aaaaagacgg ataatttgcc tagtgggatt 240 gggcctggtg gtcttcttct tcagttttct actttcaata tttcgttcca agtaccacgg 300 ctatccttat agctttttaa ttaaatgaag ccaagtggga tttgcataaa gtgaatgttt 360 accatgaaga taaactgttc ctgactttat actattttga attcattcat ttcattgtga 420 tcagctagct tattcttgtg tac 443 <212> Type: DNA <211> Length: 443       SequenceName: # 495       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atcatccttc cttagactga tgctttgact gaatcatcac tagctatggc attaaaaggc 60 ctctcttctc atctggtgcc aaaggttccg ttgcagcttt ttacaaccat ccggtgtggt 120 ttggaggatt tgtttttttt ttttcccaac agaaaagaac agccattaga agaaggctcc 180 cattttctga tgttccgccc cactgtgaag agtgtgctcg ttttaaattc atgttgattc 240 ttgtaagcac tggactgtct tcatcaagta tttccctaca gaactcctca agaaaacaga 300 gatcatttgg ctagagattg tctgagtgac tccaagctac tcactgtatt ggacgggagt 360 agtaatttat tttaaagata aagtgactaa gtggggaaat ttataaagct aaatattata 420 tattttattt ttcatacatg tttgaagtgc aaatctgtgg atattccatt tgtaggacca 480 agtcgacatg cccatcctga cattgtatgc tacgagaact cttctgatg 529 <212> Type: DNA <211> Length: 529       SequenceName: # 496       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagcagtacc atctgggtct ggatcaaaaa ctcagaaaat acgtggttgg agagctcatc 60 tggaattttg ccgatttcat gactaaccag ngtcagccca agncnacccc ntcggtcant 120 ctgttcctgc cgtcctntga ggagcnccaa gccaacaagg ccacactggt gtgtctcatg 180 aataacttta tccgggaatc ttgatggtga cctggaaggc agatggtacc ctcatcaccc 240 agagcgtgga gangaccacg ccctccaaac agagcaacaa caagtacgtg gccagcagct 300 acctgagcct gacgcccgag cagtggaggt cccgcagaag ctacagctgc caggttatgc 360 aagaagggag caccgtggag aagtcagtgg cccctgcaga atgttcatag gttccagccc 420 ccaccccacc cacaggggcc tggagctgca ggatcccagg ggaggggtct ctct 474 <212> Type: DNA <211> Length: 474       SequenceName: # 497       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggaacactg ctctcagaca ttacaagact ggacctggga aaacgcatcc tggacccacg 60 aggaatatat aggtgtaatg ggacagatat atacaaggac aaagaatcta ccgtgcaagt 120 tcattatcga atgtgccaga gctgtgtgga gctggatcca gccaccgtgg ctggcatcat 180 tgtcactgat gtcattgcca ctctgctcct tgctttggga gtcttctgct ttgctggaca 240 tgagactgga aggctgtctg gggctgccga cacacaagct ctgttgagga atgaccaggt 300 ctatcagccc ctccgagatc gagatgatgc tcagtacagc caccttggag gaaactgggc 360 tcggaacaag tgaacctgag actggtggct tctagaagca gccattacca actgtacct 419 <212> Type: DNA <211> Length: 419       SequenceName: # 498       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagaactgct tgaacctagg aggcggaggt tgcagtaagc cgagatcgca ccatttgaca 60 cagcaagtct ccgtctcaaa actacaacaa caacaacaac aacaaccaaa ttttgcaccc 120 ctgcctcatc ttcctggcan ggcccagncc ccagncccag gggancccca gacgtctcca 180 gtgccttgga taagctgaag gagtttggaa acacactgga ggacaaggct cgggaactca 240 tcagccgcat caaacagagt gaactttctg ccaagatgcg ggagtggttt tcagagacat 300 ttcagaaagt gaaggagaaa ctcaagattg actcatgagg acctgaaggg tgacatccca 360 ggaggggcct ctgaaatttc ccacacccca gcgcctgtgc tgaggactcc ctccatgtgg 420 ccccaggtgc caccaataaa aa 442 <212> Type: DNA <211> Length: 442       SequenceName: # 499       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttacctacat ggtgactgtt cggtctaatt cagaaacaga agtactaaaa gaatactaaa 60 aagtttttac ccattatctc tatccctgtt ttctttttgc aattctcagc tgcagggagc 120 aagaaaatac acagcagata ggaaatgttt gtttgcatcc tggctttctc aacngcactt 180 tacgtccttg aatattctag atatttactc cttcaagaag tcaggagtat atccaggcct 240 acctatcatc cttgccatcc ccattaaccc tcatttttca gtatgtgttt tacatttatg 300 gttatttttc agtctatagt atctgttcac tcattgctct atcacatctg agtttctccg 360 tctttctttc cactagattg taagctcctt aagggcaagg tcggcatata agcaaagttc 420 tgtaaacacc gtgaaggtac catgagttct a 451 <212> Type: DNA <211> Length: 451       SequenceName: # 500       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agtgctaacg cacaatcgct taaaatcact aatgaagatt ctgagtgaag tgactcctga 60 ccagtccaag ccagaaaact gatcctgtac caaagcttga gtgtcaggtt caggctttat 120 tgctgtcttc aacaacaggt gctgcttagt catttcttga aaaagattgg cttcaagaat 180 ggaggggaaa tgcagtttct atttaccttt aggctgattt tccaaattat ttgtgaagct 240 gtttttagaa gatgagagac taaggattct tctcttttat agctatttgc cttaagaact 300 tactttagat tcttattgaa ttcataatac ttatctctga aaatgtcttt gactgtaaat 360 ttaggaatta agatgcagag tcccatgtgt cctctgatct aaagttgcat ggttggtctg 420 aaaatagagt tgggcttaat gttgacttct attactcctg c 461 <212> Type: DNA <211> Length: 461       SequenceName: # 501       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaactatgt ctggaaggct gtggtccaag gccatttttg ctggctataa gcggggtctc 60 cggaaccaaa gggagcacac agctcttctt aaaattgaag gtgtttacgc ccgagatgaa 120 acagaattct atttgggcaa gagatgcgct tat 153 <212> Type: DNA <211> Length: 153       SequenceName: # 502       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccttgcatg gtgcctgtag ggggatttgc tttgctgtnc cattggggta canctnctgc 60 tcttactcta gaccnaaaag tcgggttgag tgactggtgg cagggccacn ganagagaca 120 gcggggaggg tggctgaccc tggcggncct ggactgagcg tctggaggag tcgtggaggc 180 tctttccctt ctttctcctc tgagagctcg ttcttcaggc tcttccagct tgtcatgtcg 240 agtgcctggc cactgctcag ggttggaggc tcagtccctt tgccctgtct gttccagctc 300 tggagctaac tcagggatcc ctgatcaggg ttacataggt ttggtaaaat gagtgctgga 360 aattaacttt ctcccagtag tcttaggtca tgctcagtga acttaaactt tatccagata 420 tggttttcct tcagcctttc tattcccttt ctagccagtg aaagacccgc tgcc 474 <212> Type: DNA <211> Length: 474       SequenceName: # 503       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttgacagggt agcatcacgc ccacagacta caccctctcc aagtgctacc tcccacgtga 60 ggatgtggtt ttgatcatct actgtggagt ggtgggcttc cttgtggtcc tcacactcac 120 tcactttggg cttctagcct caccttttct ttctggtttg aacttgctcg gaaagcgtaa 180 gacaagatga agagcaggcg ccattataaa tatcaaagcc caagaaatgg aactttgggc 240 agagatcatg ttagaatcaa gtggatgatg agaccaatta caggccgtct ctctgcacag 300 cacagaaatt ctcaatcact gaaatgagta actgcaaaat aaatagttga ttgtactgtt 360 ctcatgctat aaaagtggac aggtactcta caacaaatct gttttctcat ttttatcaaa 420 tatatgtatc atcaaaggtt gcatctgtac agtatgtaaa tgctattaat gtcgtcactc 480 acatgcacga cagtccttgt tcccccagga agggcctggt ggccccagca cacacttggg 540 attatgtgta tacataaata aatattgggc tgtttccctc ttc 583 <212> Type: DNA <211> Length: 583       SequenceName: # 504       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cactgcagct gatccagatt accaagagaa ataccaagaa ttacttgaaa gagaggactt 60 ttttccagat tatgaagaaa atggaacaga tttatccggg gctggtgatc catacttgga 120 tgatattgat gatgagatgg acccagagat agaagaagct tatgaaaagt tttgtttgga 180 atcagagcgt aagcgaaaac agtaaagtta aatttcagca tatcagtttt ataaagcagt 240 ttaggtatgg tgatttagca gaacacaaga gagcaagaaa atgtgtcaca tctataccaa 300 attnaggatg ttgagttatg ttactaatgt atgcaacttt aattttgttt aacactatct 360 gccaaaataa actttattcc ctataactta aaatgtgtat atatatataa tagtttatta 420 tgtacagtta attctactgt tttggctgca ataaaatcga 460 <212> Type: DNA <211> Length: 460       SequenceName: # 505       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgatggggg cggccaaggt gacactgggt ccaggagctc cctggggccc tggcctacca 60 ctcactggcc tcgctccccc tgtccccgaa tctcagccac cgtgtcactc tgtgacctgt 120 cccatggatc ctgaaactgc atcttggccc tgttgcctgg gctgacagga gcattttttt 180 tttttccagt aaacaaaacc tgaaagcaag caacaaaaca tacactttgt cagagaagaa 240 aaaaatgcct taactataaa aagcggagaa atggaaacat atcactcaag ggggatgctg 300 tggaaacctg gcttattctt ctaaagccac cagcaaattg tgcctaagcg aaatattttt 360 tttaaggaaa ataannacat tagttacaag attttttttt tcttaatgta gatgaaaatt 420 agcaaggatg ctgcctttgg tctctggttt ttttaagctt tttttgcata tgttttgtaa 480 gcaacaaatt tttttgtata aaagtcccgt gtctctcgct atttctgctg ctgttcctag 540 actgagcatt gcatttcttg atcaacca 568 <212> Type: DNA <211> Length: 568       SequenceName: # 506       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacattgcct gtatgatcgg gtaccgacct tgcccctgga tgaaatggtg ctggtccttc 60 ttcaccccgc tggtctgcat gggcatcttc atcttcaacg ttgtgtacta cgagccgctg 120 gtctacaaca acacctacgt gtacccgtgg tggggtgagg ccatgggcnn ggccttcgcc 180 ctgtcctcca tgctgtgcgt gccgctgcac ctcctgggct gcctcctcag ggccaagggc 240 accatggctg agcgctggca gcacctgacc cagcccatct ggggcctcca ccacttggag 300 taccgagctc aggacgcaga tgtcaggggc ctgaccaccc tgaccccagt gtccgagagc 360 agcaaggtcg tcgtggtgga gagtgtcatg tgacaactca gctcacatca ccagctcacc 420 tctggtagcc atagcagccc ctgcttcagc cccaccgcac ccctccaggg ggcctgcctt 480 tccctgacac ttttggggtc tgc 503 <212> Type: DNA <211> Length: 503       SequenceName: # 507       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acctaacttg cgccggaaac cagatnnnan tngcantggc nttanttgtt ttttttgttt 60 tgttttggnn tttttttttt ttggcttgac tcaggattta aaaactggaa cggtgaaggt 120 gacagcagtc ggttggagcg agcatccccc aaagttcaca atgtggccga ggactttgat 180 tgcacattgt tgttttttta atagtcattc caaatatgag atgcgttgtt acaggaagtc 240 ccttgccatc ctaaaagcca ccccacttct ctctaaggag aatggcccag tcctctccca 300 agtccacaca ggggaggtga tagcattgct ttcgtgtaaa ttatgtaatg caaaattttt 360 ttaatcttcg ccttaatact tttttatttt gttttatttt gaatgatgag ccttcgtgcc 420 cccccttccc ccttttttgt cccccaactt gagatgtatg aaggcttttg gtctccctgg 480 gagtgggtgg aggcagccag ggcttacctg tacactgact tgaga 525 <212> Type: DNA <211> Length: 525       SequenceName: # 508       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgtcacttgc aacttgctat tcgtggagat gaagaattgg attctcttca tgcacagggc 60 ttaagcaant tgcatggtcg gnnggtgtca ttccacacat ccacaaatct ctgattggga 120 agaaagngac aacnagaaga ctgntctaaa ggatgcctgg attccttgtt atctcaggac 180 tctaaatact ctaacagctg tccagtgttg gtgattccnn nnngnnnngt ntnctctnnn 240 ngtgaaaaac acaatntttg cctttttgta attctatttg agcaagttgg aagtttaatt 300 agctttccaa ccaaccaaat ttctgcattc gagtcttaac catatttaag tgttactgtg 360 gcttcaaaga agctattgat tctgaagtag tgggttttga ttgagttgac tgtttttaaa 420 aaactgtttg gattttaatt gtgatgcaga agttatagta acaaacattt ggttttgtac 480 agacattatt tccactctgg tggataagtt caataa 516 <212> Type: DNA <211> Length: 516       SequenceName: # 509       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atccaagtcc ggctagtacg cgaattggag aaaaagttca gtgggaagnc atgtncgtnc 60 tttatcnnnc tcagaggaga attnctgncc taagnccaac tcgaaaaagn ccgtacaaaa 120 aataagcaaa agcgtnccca ggagnccgta ctctgacagc tgtgcacgat gnccatcctt 180 gaggacttgg tcttcccaag cgaaattgtg ggcaagagaa tccgcgtcaa actagatggc 240 agccggctca taaaggttca tttggacaaa gcacagcaga acaatgtgga acacaaggtt 300 gaaacttttt ctggtgtcta taagaagctc acgggcaagg atgttaattt tgaattccca 360 gagtttcaat tgtaaa 376 <212> Type: DNA <211> Length: 376       SequenceName: # 510       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacgcggtcg taagggctga ggatttttng gtccgcacgc tcctgctcct gactcaccgc 60 tgtncgctct cgccgaggaa caagtcggtc aggaagcccg ngcgcaacag cncatggctt 120 ttaaggatac cggaaaaaca cccgtggagc cggaggtggc aattcaccga attcgaatca 180 ccctnnaaca agccgcnaan cnnntaanan tccttggaaa aggtgtgtgc ntgacttgat 240 aagaggcgca aaagaaaaga atctcaaagt gaaaggacca gttcgaatgc ctaccaagac 300 tttgagaatc actacaagaa aaactccttg tggtgaaggt tctaagacgt gggatcgttt 360 ccagatgaga attcacaagc gactcattga cttgcacagt ccttctgaga ttgttaagca 420 gattacttcc atcagtattg agccaggagt tgaggtggaa gtcaccattg cagatgctt 479 <212> Type: DNA <211> Length: 479       SequenceName: # 511       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatggggatc tcctccaaag agcagatttc agcattgcct gacagtcttg gttttaggct 60 tgtttttttg taaacctgtg tgtttgtaga gatttcagac atcttctgat ttcttctcac 120 ctatattccc tggttaagag gtcaggggta gtgaatgttt ccttaagttc ctttttaaac 180 ttcccattgg tatgtaaatt ccaaatggca gatgctgtca ataaccttgc catggatgac 240 ctttgtgtag gtagtccttg cacctcatgc aggataagcc aattttaact ttctacaatg 300 ggtgcctcaa tagtttcata atcttcatga agttgcatcc tttggcagct tcttacagtt 360 tattttcact tccaatgtag ca 382 <212> Type: DNA <211> Length: 382       SequenceName: # 512       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagtaaggtt gggggctcac atttgggcag agtgagtgga ctaggactgc tccagaggcg 60 tggtcttaac gttgtccttt tcccctggtt ctaggaactt ttgactg 107 <212> Type: DNA <211> Length: 107       SequenceName: # 513       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggggacaga gtctcactgt gtcactcaga ctggagtaca gtgatgcgat ctcggctcac 60 tgcaacctcc gcctcctggg ttcaagcgat tctcctgctt cagcctcctg agtagctggg 120 attacaggtg cacaccacca cgcccggnta atttttgtat ttttagtaga gatggggttt 180 caccatgttg gtcaggctgg tcttgaactc ctgacctcgt tcctgcctta gcctcctaaa 240 gtgccgggat tacaggcgtg aaccaccgca cctggccagt actacatcca ttttattgaa 300 tnattttgaa tgacttaaag ttcaactatg aaaaagcttt cttttcacat gtactttttg 360 attaggtatt atcaacttat gaaacttgaa gatgtgaagt gacaggtttt gcatgtgatg 420 agtgttttct gttaaaaaat aaatattgaa atattaaccc attaaataca tttttatggt 480 aacctatgtt ttacagtgga gttttaaaaa tgctaggtct ttctttcatt ttattg 536 <212> Type: DNA <211> Length: 536       SequenceName: # 514       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggggaactgg aaagtgtgcg aattcatcac aagcatgcct actgagcact ggcgggtcag 60 actgcagccc aggatggaaa accttgtttg cactaaccag aaagatcctt gtctgatttt 120 ggcagaatta aacggtgact tactaatgat agaactggta caagtagcat caactacaaa 180 gtgaaactca ctttagccta catggatctc actgtacata catatcaatc cctaaattga 240 atggtggagg ttgcaaagtg tatttgcaca ttttaaatca ttctgtttta gtttttccac 300 ttttattcat tcttatccct agccccttct cgttccctca tcccttctgt gggccaataa 360 a 361 <212> Type: DNA <211> Length: 361       SequenceName: # 515       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctaagcaa gcatctaaaa agactgcaat ggctgctgct aaggcaccta caaaggcagc 60 acctaagcna aagattgtga agcctgtgaa agtttcagct ccccgagttg gtggaaaacg 120 ctaaactggc agatta 136 <212> Type: DNA <211> Length: 136       SequenceName: # 516       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggtgacttg ggttggatga ccagagggtc catggtggga ccatttcaag aagcagcatt 60 tgccttgcct gtaagtggga tggataagcc tgtgtttaca gacccaccgg ttaagacaaa 120 atttggatat catattatta tggtcgaag 149 <212> Type: DNA <211> Length: 149       SequenceName: # 517       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgctgtttg ggtacaagcc ctccaagata gaagtggatt ctgtgatgtc ttcaataaat 60 ccaaatactt ctggtatatt actcgagggg tttttaaata ttgtcaggaa aaagaaggaa 120 gctcaacgat atcggaacga agtaagacac atcttcacag cctttgacac ctactatcgt 180 ggatttttaa ctttggaaga tttcaaaaaa gcatttaggc aggtggctcc caaattaccg 240 gaaaggactg ttcttgaggt attcagggaa gtagatcgag attcagatgg tcacgtcagc 300 tttagagact ttgaatatgc cctgaactat ggacagaagg aagcctaact attgtgaact 360 acttttggta actctgggga gatcaataga ttgtaatgtc agcagactct actctactaa 420 <212> Type: DNA <211> Length: 420       SequenceName: # 518       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatgtggag catgttccgc tgtccttgga cagagccatg cggctggtga aagatgtctt 60 catttctgcg gctgagagag atgtgtacac tggggacgca ctccggatct gcatagtgac 120 caaagagggc atcagggagg aaactgtttc cttaaggaag gactgatctg tgtgctctta 180 tcaccaatca gttcagacct ggttgatttt gtactttgga actgtacctt ggatggt 237 <212> Type: DNA <211> Length: 237       SequenceName: # 519       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccctcccat ctgggaacac gggaggagca ggcttccgct gtcctgggcc ctggggtccc 60 ggagtcgggc tcagatgaaa gggttccccc cttccagggg cccacgagac tctataatcc 120 tggctgggag gccagcagcg c 141 <212> Type: DNA <211> Length: 141       SequenceName: # 520       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctacagctg gactggactc catttagcct tttaagccga ggttcctatt ttaactgaca 60 gcttnccttt ggggtgccag gcagcgaggc cccccncccc tancctgcca tgtacttcaa 120 gctcacttct tctttttgag ttccgcaact tgctcctgcc tcccagcccc actggcactg 180 accatgacca cctacttcta tttttttttt agagtttctt tttttgatca cttactttca 240 aagcacacag tcaaacaagg ttatgccaaa tttccaggcc tttttgaagt attgagaagg 300 ggaaggggat ttctcacttc aattatagat cataatagga agcaaaaaga aaaaaatgaa 360 aagcaaacat atgcacgcac ttttcttgtt gacaaagcaa gaatataggt ttgctgtgta 420 ggtttggtgc tctattgatt ggtgagtgac cagagcaagt atgaaggtga tgctgccaaa 480 gcacaagcca gtttctt 497 <212> Type: DNA <211> Length: 497       SequenceName: # 521       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: catgcagact gttagctttt accttaaatg cttattttaa aatgacagtg gaagtttttt 60 tttcctcnaa gtgccagtat tcccagagtt ttggtttttg aactagcaat gcctgtgaaa 120 aagaaactga atacctaaga tttctgtctt ggggtttttg gtgcatgcag ttgattactt 180 cttatttttc ttaccaattg tgaatgttgg tgtgaaacaa attaatgaag cttttgaatc 240 atccctattc tgtgttttat ctagtcacat aaatggatta attactaatt tcagttgaga 300 ccttctaatt ggtttttact gaaacattga gggaacacaa atttatgggc ttcctgatga 360 tgattcttct aggcatcatg tcctatagtt tgtcatccct gangaatgta aagttacact 420 gttcacaaag gttttgtctc ctttccactg ctattagtca tggtcactct cc 472 <212> Type: DNA <211> Length: 472       SequenceName: # 522       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caaacgcaga gcccttgcag gttctgtccg tctctcgggc cattacacac cctagctgga 60 actctaccac catgaacaat gacgtgacgc tgctgaagct cgcctcgcca gcccagtaca 120 caacacgcat ctcgccagtt tgcctggcat cctcaaacga ggctctgact gaaggcctca 180 cgtgtgtcac caccggctgg ggtcgcctca gtggcgtggg caatgtgaca ccagcacntc 240 tgcagcaggt ngctttgccc ctggtcactg tgaatcagtg ccggcagtac tggggctcaa 300 gtatcactga ctccatgatc tgtgcaggtg gcgcaggtgc ctcctcgtgc cagggtgact 360 ccggaggccc tcttgtctgc cagaagggaa acacatgggt gcttattggt attgtctcct 420 ggggcaccaa aaactgcaat gtgcgcgcac ctgctgtgta tactcgagtt agcaagttca 480 gcacctggat caaccaggtc atagcctaca actgagctca ccacaggccc tccccagctc 540 aacccattaa agacccaggc cct 563 <212> Type: DNA <211> Length: 563       SequenceName: # 523       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cttcctcgga ggcagcattg ttaagggagg ccctgtgcaa gtgctggagg acgaggaact 60 aaagtcccag ccagagcccc tagtggtcaa gggaaaacgg gtggctggag gccctcagat 120 gatccagctc agcctggatg ggaagcgcct ctacatcacc acgtcgctgt acagtgcctg 180 ggacaagcag ttttaccctg atctcatcag ggaaggctct gtgatgctgc aggttgatgt 240 agacacagta aaaggagggc tgaagttgaa ccccaacttc ctggtggact tcgggaagga 300 gccccttggc ccagcccttg cccnatgagc tccgctaccc tgggggcgat tgtagctctg 360 acatctggat ttgaaggctc caccctcatc acccacactc cctattttgg gccctcactt 420 ccttggggac ctggcttcat tctgctctct cttggcaccc gacccttggc agcatgtacc 480 acacagccaa gctgagactg tggcaatgtg ttgagtcata tacatttact gaccactgtt 540 gct 543 <212> Type: DNA <211> Length: 543       SequenceName: # 524       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttatcagtg cttcccgagt gagcatggaa cacttcgagt tccnagggtt atagacagtc 60 gttcccagtg tggctgaggc cacccagagg cagcagagca ttcagactcc aaacagaccc 120 ctgttcatgc cgangcttgc acgaccgccc cagttcctgt ggctccctcg gaatgctaag 180 gggatcggac atgaaaggac cctgtgagcc gattgtccta tctccagcgg ccctgtcatc 240 cagctcactc atcaatgggn ccagtcaggc ccaggcactg ggctccggag gactcaccac 300 tgccccctgc tgccatgtgg acctggtgca agttgaggac ttcttgctgg tctagtcacg 360 catgcagtgt tggggatgcc ttggttttta ctgct 395 <212> Type: DNA <211> Length: 395       SequenceName: # 525       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgaaagaat actcaggctt tgcaggagtt agccgaccac gaggaacctt tcatgacgac 60 agagatgatg gtgtggatta ttgggccaaa agaggaagag gtcgtggtac ttttcaacgt 120 ggcagagggc gctttaactt caaaaaatca ggtagcagtc ctaaatggac tcatgacaaa 180 taccaagggg atgggattgt tgaagatgaa gaagagacca tggaaaataa tgaagaaaag 240 aaggacagac gcaaggaaga aaaggaataa taaatatgaa gtaagattac aacagagcag 300 aacttgcacc caccattttt tttacctgat ttttgttttc aaataagaat gtaagcattt 360 tacttaaatt ttactgtttg caagtagtct atagaaattt tgttttaagt cttcaaatat 420 cttgagaaat agtagactgt atgttgaaaa ttgtactgaa ataaagtaga aanttgttac 480 gtaccatatt tgtaactatc aacttttaaa acttttaacg tttttgttac atgcattgta 540 <212> Type: DNA <211> Length: 540       SequenceName: # 526       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccaacgcaaa ttcgcaaact ttcttaaaac attatgagtt ncnntttgct attttttttt 60 ttttttttag ctcatcggct atcgttagtg ctagtggatt ttacatgtgg cccnnnannn 120 nnnnncnnnc aacgtggccc agagaagcca aaagattgga tacgcatcag acagatggaa 180 aagggagatt cagactgttt ttcagggagg tggctgggtt tacacgctaa tcccgattca 240 ccctgtccaa actgcctaag ccctccgcca ttntcaagcc ctgcagtcac agctacacag 300 atcacagctt cagccaggag ctgggcagaa ggccaanagg ctgttcccac caggctgctc 360 agggntggtc ttttaggacc cttcccttga gccctntatg gtgtggcaaa gccttcattg 420 ccttaactgg agccccatca gctccagctg ctctgtnttn tttgcccnca atgctttgcc 480 cctgagacaa atggaggcct gtcctgacct gtctcaccat gtacatagct t 531 <212> Type: DNA <211> Length: 531       SequenceName: # 527       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaagcagctt tttaacagcc tggctacaca ggaaggcgaa tggaaggctc tgaagaggaa 60 aaagttcaaa aaataaatta cattttataa ataagnnaan naannnnana nnnnnnnnnn 120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaat 180 tncccnacct cnggtnntcc acntgcnttn gnccccnnaa ttataggtgt gagccacagc 240 acccagccaa aaaagtaatt ttttttagag taataatgct ataatgttgg tgtgattcca 300 acctccagct ccccccancc gctgcctgcg gttttgtttc tgttaaaacg tcacctgatg 360 aaatagaatg aatcctgaaa tgcacctctg ggatcgggaa tggtctgtgt gttatcagct 420 gcgactggtt cactgcgtct ggacaagcct catggggact ggggattctg gccagtgtaa 480 tttctgtcaa ccacggacgt ttgccttcat gtgtagaatt tac 523 <212> Type: DNA <211> Length: 523       SequenceName: # 528       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtatacat cggtgcaggc ttcctggatg acagttgggt gatatgtgtc atgtggccta 60 aaagcctcca tgtcatttga cctacgaatt ctatctttgg gaatttatcc taagaaanta 120 cttanggatt tanttngtga taagatgttc atcccagcat tgcaatggag aaaaatggga 180 agcaatggtt tggttgggaa tttattcctt ttctgctgta acgaaagttt gcaatagggg 240 attgcttaag taaattattg tatctccatc cagatggtgg agtaccgcgc agacattaaa 300 agtcatgtaa aagaacatct gactgaaaga aaaatgctcc ttgaatatta aaaggttgta 360 aaaatagtgc atgttatgtg atttcaattt tgttttttaa aatatgggtg tatgcttgta 420 tacgtagagc agataaaaaa gacggaaggc atactaaaaa atgttgagtg gttatctttg 480 tatggtggaa caaagtcact gtaattttca tctttggtt 519 <212> Type: DNA <211> Length: 519       SequenceName: # 529       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtgctgag ttaaacgcaa atttcaggta aacaaaagat aattttctag cattaatatg 60 ccccacgcaa tatttggaac acttatgtga aaaatgattt gtttttctga aattnacgtt 120 tctctctnag tcctgtaact gtccccgagg ggattgagca gaagctcggg tatgagccct 180 gaggttnact gccggttatt tntctgtcct gggaacagcc tgacccacct ccctntctcc 240 atgtagccag tgnggggagg gggagacaca gaaccnacca cagccagggg cgtccccatg 300 gcnactgtgn cccggcccct cctctcttgc ctnactctcc tctcttgcnc tnactctaga 360 cactaactta gttccaggtt cggtgccctg ntggngctcc tgttnccaat agcttaggtc 420 ccatggtggg ggagga 436 <212> Type: DNA <211> Length: 436       SequenceName: # 530       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaaactgaa ttgagtcaac ttctgaagat aaaacctgaa gaagttactg ggagctgcta 60 ttttatatta tgactgcttt ttaagaaatt tttgtttatg gatctgataa aatctagatc 120 tctaatattt ttaagcccaa gccccttgga cactgcagct cttttcagtt tttgcttata 180 cacaattcat tctttgcagc taattaagcc gaagaagcct gggaatcaag tttgaaacaa 240 agattaataa agttctttgc ctagtataca gttttatttt tttatttcat tgacaccgat 300 ctgtacacag taaaaaaaat tgcttataga aagctaatca tggcatgtaa tatggctgat 360 aacctttgga att 373 <212> Type: DNA <211> Length: 373       SequenceName: # 531       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atattttgac agtttaggct tcattaatag aactattctg attatttgga ctgcattaat 60 tggtcactga ctggccatcc aattaccatt ttttctttca gtccaaaata gttagaccct 120 tgcatacaga agtggtattt tggtttttaa tcagatttgg tttcatcaga agcagcaaga 180 atggacctga tgtctttaaa agcatagccg acaatggtag cttctcaagt tatgaaataa 240 aactgagaga taatggagaa aataattttt atgggttttt ttggttatgg tgctattcct 300 aaggttaact ttgaatatgt gacacacaca ctcctaagta cctttaa 347 <212> Type: DNA <211> Length: 347       SequenceName: # 532       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggggctgt tcatgggagc atccacacgt ggcctctctg tgtggcttgg gctcctcaca 60 gtccggaagc tgggttccaa gagcgactgt tccagcagcc tcaggcagaa gctacaaggc 120 tgcccagatg cgatcctgcc cagatgtgtc ctcactgtca cccaggaagg gaagccccgg 180 aacaccaccc tcagtcacag gcatggggcc cactgcaagg cacaacccac tccagagctc 240 ccaaggccgc ctcccctggg acctgcagcc agctggctcc ataactgctt ttccngtttc 300 cntccnaggc attttcatcc ntagccctac tttgtgcntg ggatctgagg gggatagcaa 360 gcggagaaag aagggatcta gagggagaag attctagatc cttcttttga ctgccagctg 420 attttgattg ccagctttac ctgcttcatg agctcagcca agtcacttaa cctctcagag 480 cttcactgtt ct 492 <212> Type: DNA <211> Length: 492       SequenceName: # 533       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccttaccgga aacctgactg caaagtggga agaattacca caactgaaga ctttaaacat 60 ctggctcgca agctgactca cggtgttatg aataaggagc tgaagtactg taagaatcct 120 gaggacctgg agtgcaatga gaatgtgaaa cacaaaacca aggagtacat taagaagtac 180 atgcagaant ttggggctgt ttacaaaccc aaagaggaca ctgaattaga gtgactgttg 240 ggncagggtg ggaggatggg tggtcaggta agacagactc tagggagagg aaatcctgtg 300 ggcctttctg tcccanccct gtcagcactg tgctactgat gatacatcac cctggggaat 360 tcaaccctgc agatgtcaac tgaaggccac aaaaatgaac tccatctaca agtgattacc 420 tagttgtgag ctgttggcat gtggttagaa gccatcagag gtgcaagggc ttagaaaaga 480 acctggccag acctgactcc actcttaaac ctgggtctt 519 <212> Type: DNA <211> Length: 519       SequenceName: # 534       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccaaattatt aattgtcctg tgtctatgtc cctctagctg ttcttttttg tacttttctg 60 gttccaaacc agtttattct gtggttctat aataagtttt gatataatct tggcttctta 120 aaaactgtgt atcattaaaa tatatgttct gcaagaatta aaactgagtc catgaaaata 180 ccataggaag acataaaact ttaaaaggca actcaaagat gatggaaacg cacttacaag 240 tggtgaccaa aatttttagg tgaagtcgag cactctaatt agagaactgg aggaaccaca 300 tataacactt aacttcccct a 321 <212> Type: DNA <211> Length: 321       SequenceName: # 535       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgatcatagc tactacttca ttgcaacctt tattactgac cacatcagac atcatgctaa 60 atacctgaat gcatgaaaaa actccaaata agagaatctc ttcaggatta taaaagttgt 120 aaaatgcaac tgtattgctg agcaaaa 147 <212> Type: DNA <211> Length: 147       SequenceName: # 536       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagccaacaa ggccacactg gtgtgtctca taagtgactt ctacccggga gccgtgacag 60 tggcctggaa ggcagatagc agccccgtca aggcgggagt ggagaccacc acaccctcca 120 aacaaagcaa caacaagtac gcggccagca gctanctgag cctgacgcct gagcagtgga 180 agtcccacan aagctacagc tgccaggtca cgcatgaagg gagcaccgtg gagaagacag 240 tggcccctac agaatgttca taggttctnn anccctcanc ccccnnccac gggagactag 300 agctgcagga tcccagggga ggggtctctc ctcccacccc aaggcatcaa gcccttctcc 360 ctgcactcna taaacccnca ataaatatnc tcattngntc aancagaaan nnnnnnnnan 420 nnnatttttt ttctcacata aattgctagc ctccccgggg ttctcagtgt ggggtacagg 480 gaattctgca cccagtgtga aaatcaccca agggagaggc tcacagcctc cctgagtcat 540 ctcaccagag gg 552 <212> Type: DNA <211> Length: 552       SequenceName: # 537       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggatttttct gatcaattgt gctttaggaa attattgaca gttttgcaca ggttcttgaa 60 aacgttattt ataatgaaat caactanaac tatttttgct ataagttcta taaggtgcat 120 aaaaccctta aattcatcta gtagctgttc ccccgaacag gtttat 166 <212> Type: DNA <211> Length: 166       SequenceName: # 538       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagaggactt atgcatttct ccaggnaaag cttgtctggg ttctatactg tgatctcatt 60 tgcctcgact acgatggaaa cattttggat gcctgcacat ttgctttgct agcggcttta 120 aaaaatgtac agttgcctga agttactata aatgaagaaa ctgctttagc agaagttaat 180 ttaaagaaga aaagttattt gaatattaga actcatccag ttgcaacttc ctttgctgtg 240 tttgatgaca ctttgcttat agttgaccct actggagagg aggaacatct ggcaacagga 300 accttaacga tagtaatgga tgaggaaggc aaactctgtt gtcttcacaa accaggtgga 360 agtgggctaa ctggagctaa acttcaggac tgtatgagcc gagcagttac aagacacaaa 420 gaagttaaaa aactgatgga tgaagtaatt aagagtatga aacccaaata aacagccacc 480 acattttcaa aacagatttg taaaaattgt atttgttaac actgtgcaca aacgtttta 539 <212> Type: DNA <211> Length: 539       SequenceName: # 539       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtctgggata attgcctatt cgctaaatga aaatgagaca cttcctgtcc ggggtaggca 60 taaaagaaac agaaataaaa gccaattaaa taggaatgac aagatgatag tgcagattca 120 aaagaaatag gtatgcacaa gtgacttaaa gcagagtcct cctctagccc aggacactct 180 tcagtctggc tgcagctggc tagcttcttt tttttttttt ttaattctaa gaaatagatt 240 gaaatgaaac gatggaaaag aagcaggact tctccccgtg ggtgtctgtg atgtcctaaa 300 aaaaaaaaaa aaaaaaaagn nnannnttcc taggactcca aacgctgtcc tgagatcagt 360 tttaacctcg tctttcgggc cgaaagtagt tcacatttcc cgagcacaag catggagatt 420 ttgaggtgcc caggttagaa tttgcgtgtc gtcctcatga tcccctgcac ttttattccc 480 cgagaatctt gcctcccggt ggctagtaca gtattgtttc cttcttgatc 530 <212> Type: DNA <211> Length: 530       SequenceName: # 540       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacttcgatg tttcatgctc atgtacttca aataatgcat gttttatagt tagtccctca 60 tcacttgaag tgacttctga gaattatgca gagtcaacat ggatcatttc acagtgagat 120 gctttatgga ttgaaggata tggtaaaatg tttatagttt actttgaaag taaaatatac 180 tatgtcttgg ttttgaggat attggataca aaactctctt cctttagggc tactgagtct 240 tgattcctga tcatcagaaa tttcaccaga aacaacttgc ttccaatata cccaattcta 300 tatgaagaat tcatggagag tgtactggca ctggaagagt ttag 344 <212> Type: DNA <211> Length: 344       SequenceName: # 541       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctgtttctg actggaacgt gggccggtcc ccagacccaa gagctgtgag ctgcctaaga 60 aatcatggca ttcacacagc ccataaagca agacagatta ccaaagaaga ttttgccaca 120 tttgattata tactatgtat ggatgaaagc aatctgagag atttgaatag aaaaagtaat 180 cnagttaaaa cctgcaaagc taaaattgaa ctactnggga gctatgatcc acaaaaacaa 240 cttattatng aagatcccta ttatgggaat gactctgact ttgagacggt gtaccagcag 300 tgtgtcaggt gctgcagagc gtncttggag aaggcccact gaggcaggtt cgtgccctgc 360 tgcggccagc ctgactagac cccaccctga ggtcctgcat ttctcagtcg gtgtgtaatc 420 acgttccagg gcccaaagcc cagctctttg ttcagttgac ttactgtttc ttaccttaaa 480 aagtaattgt agatggaaat cagtttgtgt tcggcaggag a 521 <212> Type: DNA <211> Length: 521       SequenceName: # 542       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cgtcctaggt cagcccaagg ctgccccctc ggtcacnntn tgttcccgcc ctcctctgag 60 gagcttcaag ccaacaaggc cacactggtg tgtctcataa gtgacttnta ccngggagcn 120 gtgacagtgg cctggaaggn agatagcagc cccgtcaagg cgggagtgga gacnaccaca 180 ccctccaaac aaagcaacaa caagtacgcg gcnagcagct atctgagcct gacgcctgag 240 cagtggaagt cccacngaag ctacagctgc caggtcacgc atgaagggag caccgtggag 300 aagacagtgg cccctncaga atgttcntag nntnnnaacc ctcacccccc tccccgggat 360 actgtccggg ggcccaggcc gcagtgtggg tgggtcagct tgaatccagc cttcctacca 420 gttctctacc agcacttgcc ttcctggtgt caaagagtct ttgttattat ttggctgaa 479 <212> Type: DNA <211> Length: 479       SequenceName: # 543       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaaatggtt tgccgctgga gtatcaagag aagttaaaag caatagaacc aaatgactat 60 acaggaaagg tctcagaaga aattgaagac atcatcaaaa agggggaaac acaaactctt 120 tagaacataa cagaatatat ctaagggtat tctatgtgct aatataaaat atttttaaca 180 cttgagaaca gggatctggg ggatctccac gtttgatcca ttttcagcag tgctctgaag 240 gagtatctta cttgggtgat tccttgtttt tagactataa aaagaaactg ggataggagt 300 tagacaattt aaaaggggtg tatgagggcc tgaaatatgt gacaaatgaa tgtgagtacc 360 ccttctatga acactgaaag ctattctctt gaattgatct taagtgtctc cttgctctgg 420 taaaagatag atttgtagct cacttgatga tggtgctggt gaattgctct gctctgtctg 480 agatt 485 <212> Type: DNA <211> Length: 485       SequenceName: # 544       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acctcaccgg gcctgtgata tttgctctcc tgaactctca ctcaatcctc ttcctctcct 60 ctgtggcttt tcctgttatt gtcccctaat gataggatat tccctgctgc ctacctggag 120 attcagtagg atcttttgag tggaggtggg tagagagagc aaggagggca ggacacttag 180 caggcactga gcaagcaggc ccccncctgc ccttagtgat gtttggagtc gttttac 237 <212> Type: DNA <211> Length: 237       SequenceName: # 545       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatggacagt catcaactgg cggatatagc ggtacatant natccttagc caccagggnc 60 acaannntac agtagacaat acagacagag cttttgttga gctgtaactg agctatggaa 120 tagcttcttt gatgtacctc tttgccttaa attgcttttt agttctaaga ttgtagaatg 180 atcctttcaa attgtaatct tttctaacag agatatttta atatagttgc tttcttaaaa 240 aacaaaaaaa ctactgtcag tattaatact gagccagact ggcatctaca gatttcagat 300 ctatcatttt attgattctt aagcttgtat taaaaactag gcaatatcat catggataca 360 taggagaaga cacatttaca atcattcatt gggcctttta tctgtctatc catccatcat 420 catttgaagg cctaatatat tgccaagtac tcacatggta tgcatt 466 <212> Type: DNA <211> Length: 466       SequenceName: # 546       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatgaggcc tacagggttc accaggatgt aagaggagag aggaatccac aggaccacca 60 gagaggagag ggaaccagat atgcagatca gagatagagg aagtggaacc agagagctgg 120 gagggaccaa ggttgtaagg gtggctaagt cccaccataa cagctaaggg gacctgggag 180 atgatggctc atttccaccc agccccagga tttccagagc gcacatccac aggcctggac 240 ctgggatgaa gatgaatgaa gaacatggat gcacgtggat gtagtttggc tcaggtgtcc 300 ctgcagttgg caaggagtca gtactcagtc cctgagtgtg gctgaaattt gaggtcctgg 360 ctgagccaag gagtaatgga ccagatctac ctcagtattc aagttcagtg gggacaccag 420 tggcttcaaa cttcctggtt tcatgatatc ttg 453 <212> Type: DNA <211> Length: 453       SequenceName: # 547       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caaagttact ttgtacagac cttgaagatt gaaaaaagca cgtctaaaga gccagttgat 60 tttgagcaat ggattgaaaa agatttggta cacacagagg ggcagcttca aaatgaagaa 120 attgtggcac atgatggctc cgctacttac ttgagattca ttattgtatc agcctttgat 180 cattttgcat ctgtgcatag cgttnnnnna ganngannan tagtctcaaa tctttcctca 240 taatgataac aaaatgctct tgcatgattt tttaacaata tatttaaaca ggaagttgtc 300 actgatatac tttat 315 <212> Type: DNA <211> Length: 315       SequenceName: # 548       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgctctcagc gcagttttag tcctgaggat ggaagaccag gcttgtgtgt cttgtgttgt 60 cttcgtctgt gccgtttgtc ttcgtggcca tcctgcagat gagcaccgtg tccagtgcca 120 cagcacaagg cgcctccccg ccccgccacc ccacacctct cccctttggg ctggacggga 180 acacacgtgt gtggctcagg aggaaaagct cagcctggac tgtggcagcc acggcagaag 240 gtggatcttg ggatcaattt ttataaaaat cgagacagtt ctgtggttaa atctacaaat 300 taaagggaaa ttagaagttg gcgtgaacgt ggcgtttgtg ggagtgtcac tgagatggcc 360 cgtgtgccgc ccaccccgag gcaccgcttc cctgtgcggc gctgcagagg ggccctcagt 420 gtggc 425 <212> Type: DNA <211> Length: 425       SequenceName: # 549       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccttttggg agtgcgtggt ggtggtctgg gtgtatggag ctgaccgctt cacggacgac 60 attgcctgta tgatcgggta ccgaccttgc ccctggatga aatggtgctg gtccttcttc 120 accccgctgg tttgcatggg catcttcatc ttcaacgttg tgtactacaa gccgctggtc 180 tacaanaaca ccnacgtgta cccgtggtgg ggtgaggcca tgggctgggc cttcgtgctg 240 tcctccatgc tgtgcatgcc actgcacctc ctgggctgcc tcctcagggc caagggnacc 300 atggctgagt gctggaagna cctgacccag cccatctggg gcctccacca cttggagtac 360 cgagctcagg atgcagatgt caggggcctg accaccctga ccccagtgtc cgagagcagc 420 aaggtcgtcg tggtggagag tgtcatg 447 <212> Type: DNA <211> Length: 447       SequenceName: # 550       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagatgttct tggtcacctg atggaagcaa aatagcagct ggctcagccg acaggtttgt 60 ttatgtgtgg gataccacaa gcaggagaat attgtataag ctgcccggcc atgctggctc 120 catcaatgaa gtggctttcc accctgatga gcccatcatt atctcagcat cgagtgacaa 180 gagactgtat atgggagaga ttcagtgaag atatggactg gaagactcca aggccgcttg 240 tctttgagac ctcagactgc ataagtgatg ccaaatgttg gatgtccagg ctagcaccct 300 cccttcagat gaccattgct agcaagaaac aggaggcggt ggccatattc caaaaaccac 360 ttctgtccca tttcaccagg atgactaagg caagctccct gtggcctcta aaaaccacct 420 gccagatttc agggactgtt tttttttttc tttttctttt ttcctgtttt ctaatgcagg 480 cccaatgtga ca 492 <212> Type: DNA <211> Length: 492       SequenceName: # 551       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctctggctcc caggtgccag atgtgccatc cagttgaccc agtctccatc ctccctgtct 60 gcatctgtag gagacagagt caccatcact tgccgggcaa gtcagggcat tagcagtgct 120 ttagcctgnt atcagcagaa accagggaaa gctcctaagc tcctgatcta tgatgcctcc 180 agtttgnaaa ntggggtccc atcaaggttc agcggcagtg gatctgggac agatttcact 240 ctcaccatca gcagcctgca gcctgaagat tttgc 275 <212> Type: DNA <211> Length: 275       SequenceName: # 552       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccacgtttg caccaaaacc atgaagaagg ctgcctgggt catcatagaa aagtactaca 60 tgcacctggg caacgacttc cacacaaaca agcacatgtg caaggagatt gccattatcc 120 ccagcaagaa gctccacaac aagacagcag gttatgtcac ccatctgatg aagcagattc 180 agagaggccc agtaagaggt atctccatca agctgcagga ggaggtgaga gaaaggagag 240 acaattatgt tcctgagatc tcagccctgg atcaggagat cattgaagta gatcctgaca 300 ctaaagaaat gctgaagctt ttggactttg gtggtctgtc taacctgcag gtcactcagc 360 ctacagttgg gatgaatttc aaaatgcctc ggggacctgt ttgaatcttt tctgca 416 <212> Type: DNA <211> Length: 416       SequenceName: # 553       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtcagacg cagccgtaga caccagctcc gaaatcacca ccgaggactt aaaggagaag 60 aaggaagttg tggaagaggc ggaaaatgga agagacgccc ctgctcacgg gaatgctaat 120 gaggaaaatg gggagccgga ggctgacaac gaggtagatg aagaagagga agaaggtggg 180 gaggaagaag gtgatggtga ggaagaggat ggagatgaag atgagggagc tgagtcagct 240 acgggcaagc gggcagctga agatgatgag gatgacgatg tcgat 285 <212> Type: DNA <211> Length: 285       SequenceName: # 554       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaaagcagg gggcttcaga ccctccgact gtggcctccc gcctcccacc cgtcacactc 60 cagctccctc aaacgctcca gccccaggac catctccttt cggatgaaac ccaagaaaga 120 aaactcggaa acaaccctaa ctcgcagtgc cagcatgaag ctcccagaca acacagtgaa 180 gttgggagag aagctggaga gataccacac ggccatacgg agatcagaat ctgtcaagtc 240 tcggggtctg ccttgcactg agttattcgt ggctcctgtg ggtgtagcca gcaagcgcca 300 cctctttgag aaggaactgg cgggccagag ccgagcagaa ccagcctcca gccggaagga 360 gaacttgagg ctctcagggg ttgtgacatc aaggctcaac ctgtggatca gcaggaccca 420 ggaatctgga gatcaggacc cccaggaggc acagaaagca tcatctgcaa ccgagaggac 480 tcagtgggga cagaaatctg actcctcgct 510 <212> Type: DNA <211> Length: 510       SequenceName: # 555       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagcatatca gcatggagta cctctggtgt ggcaatgcac acttcaacct cctcttcggt 60 cacaaagagt tacatctcat cacagacaaa tggagaaatg ggacaacttg tccatcgttt 120 cactgtacca ggcatgagga tgtggcctgc atgctgcctg atcttgccta gaaccggctg 180 cacctgctgt tctcttgttt atgcaaactg gctgcacctg ctat 224 <212> Type: DNA <211> Length: 224       SequenceName: # 556       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcagaaacg gtggtgtgct ctcagtaaaa cggtattcta ttattatgga agtgataaag 60 acaaacaaca gaaaggtgaa tttgcaatag atggctacag tgtcagaatg aataacactc 120 taagaaagga tggaaagaaa gattgctgtt ttgaaatctc tgctcctgat aaacgtatat 180 atcagtttac agcagcttct cccaaagatg ctgaagaatg ggtacagcag ctgaaatttg 240 tattgcaaga tatggaatct gatattattc ctgaggatta tgatgagaga ggagaattat 300 atgatgatgt tgatcatcct ctaccaataa gcaatccact aacaagcagt caaccaatag 360 atgatgaaat ttatgaagaa cttccagggg ataagagcac tgattatgct aatttttacc 420 agggattgtg ggattgtact ggagcttttt ctgatgagtt gtcatttaag cgtggtgatg 480 tgatttacat tcttagcaag gaatacaata gatatggctg gtgggtagga gaaatgaagg 540 gagccattgg cttggtgcc 559 <212> Type: DNA <211> Length: 559       SequenceName: # 557       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agctgacggc ggagctgatc gagcaggcgg cgcagtacac caacgcggtg cgcgaccggg 60 agctggacct ccgggggtga tctgaaccct ctggcatctc tcaaatcgct gacttaccta 120 agtatcctaa gaaatccggt aaccaataag aagcattaca gattgtatgt gatttataag 180 gttccgcaag tcagagtact ggatttccag aaagtgaaac taaaatttta atccaggtgc 240 tggtttgcca actgacaaaa agaaaggtgg gccatctcca ggggatgtag aagcaatcaa 300 gaatgccata gcaaatgctt caactctggc tgaagtggag aggctgaagg ggttgctgca 360 gtctggtcag atccctggca gagaacgcag atcagggccc actgatga 408 <212> Type: DNA <211> Length: 408       SequenceName: # 558       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actgggctgt ccaggtctgg caaaggcacc cacaggctgc agggcactgt cttcctcaat 60 ggccatgcct tcttccacta caacagtgaa gacaggaagg ctgagcccct gggaccatgg 120 agacatgcgg aaggagtaga ggactgggag aagcagagcc aagttcagaa ggccagggag 180 gacatcttta tggagaccct gaacaacatc atggagtatt acaacgacgg taacgatcct 240 ccctctgtgg tggtcaccag ccaccaggcc ccaggagaaa agaagaaact gaagtgcctg 300 gcctacgact tctacccagg gaaaattgat gtgcactgga ctcgggccgg cgaggtgcag 360 gagcctgagt tacggggaga tgttcttcac ggtggaaacg gcacttacct gacctggttg 420 ttggt 425 <212> Type: DNA <211> Length: 425       SequenceName: # 559       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttcagaaggc cagggaggac atctttatgg agaccctgaa caacatcatg gagtattaca 60 acgacggtaa cgatcctccc tctgtggtgg tcaccagcca ccaggcccca ggagaaaaga 120 agaaactgaa gtgcctggcc tacgacttct acccagggaa aattgatgtg cactggactc 180 gggccggcga ggtgcaggag cctgagttac ggggagatgt tcttcac 227 <212> Type: DNA <211> Length: 227       SequenceName: # 560       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcaagtggga agagcgctgt tcaaggacca cctgagcgtg acctctgtgg ctgctacagc 60 gtgttccagt gtcctgccgg gctgtgccga gccatggaac catggggaga ccttcacttg 120 cactgctgcc caccccgagt tgaagacccc actaaccgcc aacatcacaa aatccggaaa 180 cacattccgg cccgaggtcc acctgctgcc gccgccgtcg gaggagctgg ccctgaacga 240 gctggtgacg ctgacgtgcc tggcacgtgg cttcagccca aggatgtgct ggttcgctgg 300 ctgcaggggt cacaggagct gccccgcgag aagtacctga cttgggcatc ccggcaggag 360 cccagccagg gcaccaccac cttcgctgtg accagcatac tgcgcgtggc agccgaggac 420 tggaagaagg gggacacctt ctcctgcatg gtgggccacg aggccctgcc gctggccttc 480 acacagaaga ccatcgaccg cttggcgggt aaacccaccc atgtcaatgt gtctgttgtc 540 atggcgga 548 <212> Type: DNA <211> Length: 548       SequenceName: # 561       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acaaacgggc ccgttccatg gacatagatg acttcatcag attgctacat ggattcaacg 60 cagaaggtat tcatttttcc taggtatttg gaaaacagaa attttcaagg tcaagaaaag 120 aaatgaattt tgtatttttt gtatttgaga agataatgct tttgctttac tgagacatta 180 tttacttgac tatttttggt tcaatactac tactgttgtc accatttatg attctgaatt 240 ttaaagttgg aaagttctaa gtatcaaagt ttttaatata taatgctggt ccaatctatt 300 cataataatc ttcaagttca ggagccgcag agacgcacaa ctttacactt atcatttcta 360 acagtttatt gtataaagat gttactcttc tatttactgt tatatactgt aaggccttct 420 ttaggccttt agctctgttc ctccagtaat aaaaaagtta aaatatgctt cactagtcac 480 acattcccca taccatttcg tgttattcac attccccgta ccatttcttg ttattcaca 539 <212> Type: DNA <211> Length: 539       SequenceName: # 562       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtctctgaag tatttcctcc agtttccctg cgggccccta tgtttgagtt tgatggctgc 60 tggatcctca ctcaacgaaa actcggttgg aaactgttcc gcctggcagt ccttttttgt 120 tgttttccat ctcatttccc ttccatctga aagtggcatt cagctgactt gctcatttag 180 actgttcacg gagtctgaat ctgccaacgt ggtgttggag gctccacctt gaaaagggcc 240 acagtcaggg caactttccc catacaggaa aacttgaaaa ttacatcaac agtctacgtc 300 acagccaaat tatatttcct ttataccaaa caaaactatg gagaactaaa agtacatcac 360 acaaaacgtt tatagtgttt tgcatgtgac ctatttcagt atttatataa ctagattagt 420 gctttctagc aaacggttct gttaattagc gagtcactgt tgattctgct gtggtggtaa 480 gttgataccg tgtaactaat cccgtggat 509 <212> Type: DNA <211> Length: 509       SequenceName: # 563       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctggctctt catcagattg ggcagaggac cataagcact gcttcccaca ggcattttaa 60 aaataaagtt ccagagaaac aaaaactgtt ccaggaggat gatggaattc cactgtatct 120 aaagggtggg atagctgatg ccctccttca tagagccacc atgattctta cagttggtgg 180 aacagcatat gccatatatc agctggctgt ggcttcattt cccaataaag gagtgacttc 240 aatcatccca gcaatcactt ggttcacatt cattc 275 <212> Type: DNA <211> Length: 275       SequenceName: # 564       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggccagtcct ttacttttat aggtggagaa actgagacct aagaactgaa gtgacttacg 60 tccatggcaa attgattgca gagccaaaag tggagtccag atctcctaac ttccatacta 120 gaacattttt gctgtgggga gtggagagag attgggttga tggtacctgc ctgaagtttc 180 catggttgct gggtggaaac agcactcttc cttctgtctt ggcactcaag catcccgatg 240 gacattgaat ttttccaatg attggtcatt tgatgaccag gcaggggagc agaaaaggag 300 atagtacaga ccagaagctg tttgaggatg tgttgttgcc tgaccagaca ccttgaggcc 360 agaattctaa gtagtttcaa aactcctccc tttcataccc catctactga ctttctgctt 420 tcttcaaaat gctctgttgg ccaggtgcag tggttcacgc ctgcaatccc aacacttagg 480 ctgaggcggg aggattacat gggcccagga gttcaagacc agttgaggca acataagggg 540 ctgggc 546 <212> Type: DNA <211> Length: 546       SequenceName: # 565       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtttctcttg gtcaaaaaca cactcaagtc gtctccaagt tcgaagcatt cagcaaacaa 60 tggcaaggca gagccaccag aaaggtacac ctgattttca tgacagatat ggtaatgctg 120 tattagctag tggagccact ttctgtactg ctgtatggac aagtgtagca acacaagtcg 180 gaatagaatg gaacccatcc cctgtt 206 <212> Type: DNA <211> Length: 206       SequenceName: # 566       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agaaccagat tgccatttat gactcctttt taaggaggga gtcatggtgg ccaaggacat 60 ccacatgcct aagcacctgg agctgtcaga caagaatgtg tccaaccttc ctgtcataaa 120 ggccatgcag tctctcaagt cccgaggcta cgtgaaggca cagtttgcct ggagacattt 180 ctactggtac cttcccaatg agggtatcca gtatctccgt gattaccttc atctgccccc 240 ggagattgtg cctgccactc tatgccgtag ccgtccaggg actggcaggc ctcggcctaa 300 aggtctgaag ggtgagtgac ctgcaagact cacaagaggg aaagccgaca gagataccta 360 cagacggagt gctgtgcccc ctggtgccga caagaaagcc gaggctggga ctgggtcagc 420 aactgaattc c 431 <212> Type: DNA <211> Length: 431       SequenceName: # 567       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccacgtgcag gctgatctgg tgtgtgcagg cgtgcacgtg cagcatgcac tcgctggggt 60 acgtgtgccc gtcggagcca cacacgggct gggccaaagc cacgcattca gaggggcaca 120 cgcagcgccc ggtctcggcc tcgcacaggg ctccaaagcg gcactgcccg cagcggtcac 180 agggtccttt gcgcgccacc tggatctccc gcccgagggt acaggccgtg gcctccagct 240 cgcacgcgct gccgtatgtg acgccgtcgc tgccgcacac aggatcgtag aggctcgagc 300 acgcctgcag gcattcacac gctgcctgcc cgttcttcac agcacacgtc gccccaaatg 360 cacactgcac cccgaggcat ggggacggg 389 <212> Type: DNA <211> Length: 389       SequenceName: # 568       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gccaacgcta ccaaggtctg tgggtcagat ggagtcacat acggcaacga gtgtcagctg 60 aagaccatcg cctgccgcca gggcctgcga ggggctatcg agaggagctc actgtgggat 120 ggggttgacc tctgccgcct gcctgggtat ctgggcctgg ccatggctgt gttcttcatg 180 tgttgatttt atttgacccc tggagtggtg ggtctcatct ttcccatctc gcctgagagc 240 ggctgagggc tgcctcactg caaatcctcc ccacggcgtc agtgaaagtc gtccttgtct 300 caggatgacc aggggccagc cagtgtctga ccaaggtcaa ggggcaggtg cagaggtggc 360 agggatggct ccgaagccag aaatgcctta aactgcaacg tcccgtccct tccccacccc 420 catcccatcc ccacccccag ccccagccca gtcctcctag gagcaggacc cgatgaagcg 480 ggcggcggtg gggctgggtg ccgtgttact aactctag 518 <212> Type: DNA <211> Length: 518       SequenceName: # 569       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagagcatcc ggaggttcac aacctctgtg gtccgtagga gccactgtga ggagggccct 60 gggaagaatt tgccattttc agtggaaaac aagtggtcgt tactagctaa gatgtgtttg 120 tactttggat ctgcatttgc tacaccct 148 <212> Type: DNA <211> Length: 148       SequenceName: # 570       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggaatgcac ccttgtgaga ggtcagacaa agtgccggat aacaagaaca cccacacgtt 60 gctcctggct ggtgtgttcc ggggtggtca tgacatcctg gtgcgctccc ggctgctgct 120 tttggacaca gtgacaatgc aggtgacagc cagaagtttg gaggagctgc cagtagacat 180 catcttggca tctgtgggat aagaggccag cctgcatagg acctcatacc cttccccaac 240 actacctgga agttgtgcct tcctcatgaa actggcagaa accccttccc aagcttctgt 300 attgaaaaac aattaggaat cattgcagat ttttttttat tctgctccca cctcccaccc 360 gggactactt gctggtgact tttttttttt tttttttttt aaatagggga tgattttagc 420 ttgtcctaaa tcttgctgtc cacccttcca ggaaagggac attgtaaatg aataaaacat 480 tctcaactcc tcttgaatct atccc 505 <212> Type: DNA <211> Length: 505       SequenceName: # 571       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccccgtact tccagattta ttgttatggc tcccagtggg tattggcgat tcttgtgatg 60 cagggcctca gtcagtgtcc agccatgcat aagggagagg atagtgtgta cctgccctgc 120 cctctgctat gaaggtctct gccttgtgga tcatgggact ccccttggag gatctgtgca 180 aaggggggct gggcacaaag gagaatgtcc tatttgggag ggcaggaagc aaaggaactg 240 gacagggatt ggtgggcttg gggaacggaa gtttatcttg gatacccttg aagaggctgg 300 gtctcttcac atgaagatcg aaaagggacc ctgcttccaa tttccctctt ccattcctcg 360 agctactcca gggcttagaa gaatgctctt ggtctgtggg tccagtgttg tctgtcatcc 420 atttaagtgt tcccactttc aagtgacaat cctctccttg gccctgccat agggcagagc 480 atgtctggca tagcagcctg acttttatgc cctaa 515 <212> Type: DNA <211> Length: 515       SequenceName: # 572       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggaggagat cgagggcttc cgctatcgct gcagggatgc catgcgctca gtgactaagc 60 aggccattcg ggaggcaaga ttgaaggaga tcaaggaaga gcttctgcat tctgagaagc 120 ttaagacata ctttgaagac aaccctaggg acctccagct gctgcggcat gacctacctt 180 tgcaccccgc agtggtgaag ccccacctgg gccatgttcc tgactacctg gttcctcctg 240 ctctccgtgg cctggtacgc cctcacaaga agcggaagaa gctgtcttcc tcttgtagga 300 aggccaagag agcaaagtcc cagaacccac tgcgcagctt caagcacaaa ggaaagaaat 360 tcagacccac agccaagccc tcctgaggtt gttgggcctc tctggagctg agcacattgt 420 ggagcacagg cttacaccct tcgtggacag gcgaggctct ggtgcttact gcacagcctg 480 aacagacagt tctggggccg gcagtgctgg gccctttagc tccttggcac ttccaagctg 540 gcatc 545 <212> Type: DNA <211> Length: 545       SequenceName: # 573       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacggggcag agaggctgtt cgcagagctg cggaagatga atgccagagg acttggatct 60 gagctaaagg acagtattcc agttactgaa ctttcagcaa gtggaccttt tgaaagtcat 120 gatcttcttc ggaaaggttt ttcttgtgtg aaaaatgaac ttttgcctag tcatcccctt 180 gaattatcag aaaaaaattt ccagctcaac caagataaaa tgaatttttc cacactgaga 240 aacattcagg gtctatttgc tccgctaaaa ttacagatgg aattcaaggc agtgcagcag 300 gttcagcgtc ttccatttct ttcaagctca aatctttcac tggatgtttt gaggggtaat 360 gatgagacta ttggatttga ggatattctt aatgatccat cacaaagcga agtcatggga 420 gagccacact tgatggtgga atataaactt ggtttactgt aatagtgtgc tgttcatgga 480 aaccgagggc tgcatcttgt ttatagtcat ctttgt 516 <212> Type: DNA <211> Length: 516       SequenceName: # 574       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcagataatt tttagcttag ggcctggtgg ctaggtcggt tctctccttt ccagtcggag 60 acctctgccg caaacatgct ccgccagatc atcggtcagg ccaagaagca tccaagcttg 120 atccccctct ttgtatttat tggaactgga gctactggag caacactgta tctcttgcgt 180 ctggcattgt tcaatccaga tgtttgttgg gacagaaata acccagagcc ctggaacaaa 240 ctgggtccca atgatcaata caagttctac tcagtgaatg tggattacag caagctgaag 300 aaggaacgtc cagatttcta aatgaaatgt ttcactataa cgctgcttta gaatgaaggt 360 cttccagaag ccacatccgc acaattttcc acttaaccag gaaatatttc tcctctaaat 420 gcatgaaatc atgttggaga tctctattgt aatctctatt gga 463 <212> Type: DNA <211> Length: 463       SequenceName: # 575       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagacaggct ggactcagct acatccgata ctcccagatc tgtgcaaaag cagtgagaga 60 tgcactgaag acagaattca aagcaaatgc tgagaagact tctggcagca acgtaaaaat 120 tgtgaaagta aagaaggaat aatctaccct gactaaagct tgaaatgcta catttccaag 180 gtgaagatgt gtgggcacat gttatggcag attgaaaagg atctcattcc atgggaaaaa 240 aaaaaatcct gtcttgttca taaattgac 269 <212> Type: DNA <211> Length: 269       SequenceName: # 576       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttttggcttt ggttgtgatt tcagagcata atgctatgtt ttttgtcttt ttactatgtt 60 tttcggattt ttaagtccgt aagtgcatac agttttctct aatttttaaa ccctttcctc 120 ctcccatttg gacatttgca cttggagaac acttgagttg tgaaggtttt gggcatccac 180 cccagaaagt gggaatttga ttttatcctt ccgaactgga agaacatttt tatgaagaat 240 ttttgtctag gagaatataa cagtgttacc caaggttgtg tctttaaggg tggttcattt 300 tctctgacct tttgttactc aaagtaaagt actaggagtc ctaagaaatg ttctgttctt 360 gtacattata ctgattaagt caggattaat ttgatttcaa agctgagaac agtggtaaaa 420 actcgtttac agaaatgcat tttggaagag aaaaatactg taaaacgtgt cgtgaatgtt 480 tcttcagttt cttgttcagc caatgaggaa agggcattgc ctttcttttt accattaatc 540 acttctcaa 549 <212> Type: DNA <211> Length: 549       SequenceName: # 577       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taccatttta taactctatt gccataagaa aatacactct aaaatcttga tttgaaacat 60 attagaaacc ttgattcagt gctcagtggt ctcctagtaa gaagtcaccg acggtagcgt 120 catatgagaa gaaagaaatc cccaccacct caacctctgc tgagattgtg tgctaggaac 180 agccttccct ccgtttcccc tcagtcaaac ttgagccagc ctctggatcg atgtgatctt 240 attgcatgtt tccatggggt gtacctatac tttaagccaa tcctgctgca ttcactgcta 300 agttaaataa aaagccaaga agaaaaaaaa aattttgcac tgtgcagatc ctttgctatc 360 tgacttgcat c 371 <212> Type: DNA <211> Length: 371       SequenceName: # 578       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttctattagc accacagtct gccttcagta atacacctaa aatatttttc aggaccagaa 60 gcattcagtt tgaaaatttg ncagatgcna aaccagtatt attactaacg ctctgggtca 120 aagattaggt ttttaatatt aacagtagtc tggtaaatat ttagaagtct ggcattgaga 180 aacaaaagct tgtacctgac tagtattttt atttaaaaaa attagttctg ttagcttatt 240 taaattgtgt tttatttatc cgtagaattt atatttattt cattcctttc atctcactga 300 aaactgtctg caggcccttt gatttggatt agatgtgtga agtactgtct tttgccaaaa 360 acctcaaatt acctgttctt ttcaacgtag tgggtttgtg cttgtttgga gatcagttca 420 aaaactatct gtactatctg tactgcctct gatgtt 456 <212> Type: DNA <211> Length: 456       SequenceName: # 579       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatcatcgac gccatcaggc aggagctgag tgggatcagc accacgtaag gggccggcct 60 cgctgcgctg attcgtcgag cccatccggc gacagaggac agccagaagc ccagccagcc 120 ccagactcca gtgcaccaga gcacgcacag gagcctgggc gcgctgctgt gaaacgtcct 180 gacctgtgat cacacatgac agtgaggaaa ccaagtgcaa ctcctgggtt tttttagatt 240 ctgcctgaca cggaacacca ggtctgctcg tcttttttgt gttttatatt tgcttattta 300 aggtacattt ctttgggttt ctagagacgc ccctaagtca cctgcttcat tagacggttt 360 ccaggttttc t 371 <212> Type: DNA <211> Length: 371       SequenceName: # 580       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatactgta gaattctgtt tctttaacag tagcagggaa atgtaaacta caggtgacaa 60 aaaataccca ggtaaacact ggctttggta gaattgtgca gtcattaaaa gtcaaaattt 120 tttgactttc tttttaaagc caaagaccat agttttagtt ttaagccact aggtagatat 180 ttaggggaat agtcaaaatt tactgttgaa aaagcagttg ctatgtgctt tcttaccctg 240 ttctgttcca gttttgctgg atttgtacat agccattcta gaaatagagt tgagggaaat 300 tatccatata catatcacta ataggcttct tggaattatt tagaaaagca tttttaaact 360 ggcagtggat gactgaatag gcatcatatt tctttttgtg tgtcatttaa aagtaacaaa 420 aactgccatt tgacagtaaa ggctcttggc ttctgttgga ggcatgggaa attgtctcaa 480 tt 482 <212> Type: DNA <211> Length: 482       SequenceName: # 581       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagcaagtt tccatgattt ctgaagagct ggtataggaa gtttctttct tccttttgtg 60 ttacatgtgc attaaacaga acaagctgtg tgtcatcaca gattgtactg tgggctcaga 120 aaccgtgaga gagcccccac cgtggacacc ggctctatgg ccacaggaaa aggaacgttt 180 ccaggcattt tgtctccagg gctcccgctg gacaggcacg tactgccccg gggagtaaat 240 gcggagagtt cacgaactgt gcccaacgca tgttatagcc agggtcctac taactactca 300 gtaaaagaac gtattgttgt attcctccag tgttaagcta tagccatgtt aaaagtcact 360 gtgcatttat tctcagcatc aaataccttg taacgtcttc tctgccttgt tagtgcatat 420 ttttactttt ctgatactgt aaagaatata tccagtatgt aaatgaatgt tctataaatc 480 ttttgtatag tcattttctc tgctccttaa atatcatctc 520 <212> Type: DNA <211> Length: 520       SequenceName: # 582       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacaatcgca ctttatacca cctgcgatta ctggttcagg ataagtttga ggtgctgaat 60 tacacaagca ttcctatctt tctcccggaa gtcaccattg gagctcatca gactgaccgt 120 gtcttacatc agttcagaga gctgccgggc cgcaagtaca gccctgggta caacaccgag 180 gtgggagaca agtggatctg gctgaagtga acgggccgcc ttctgctcca gctgcatcac 240 agtgatggcc aagctgcatc agccgcactc tcctggacgc catatagctt taagatcggg 300 ggagggtaaa taatgcaaaa attgcacagt ggaagaaggg gtctcacaaa aagcaatcca 360 tcctgtagta taggtaatgg agttggggga agcagcttcc attctggatg tttggaaccc 420 tttagctttg ttttggaatg gcccaccatt ctcactggaa aacagtggtc tgctgtgaaa 480 ggccagctct cggcagcccc tgtggtttca gcgtgccgct ctgtgtcatt caggttgtg 539 <212> Type: DNA <211> Length: 539       SequenceName: # 583       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaattggact aaacccgtcc tctgttccca gcacgtttct catatagccc tcagtcactg 60 agggagtccc ccgcaggatt ggagaggcac attcccttgg gacagaggct acaggttgga 120 gctttttttc ccctgtcccc caaccccatc cccacctcca cttcagaaca tggcacccca 180 cccaactggc caagtgttaa gtgatgtgct tattgagagc aactccgggt gtcttttaaa 240 atgtagagaa aaggtgacag tttaaggaaa aatatatata gaataccaga aatgccgttt 300 acccggagaa tttttttctc cccatttgtt ttgtttttac tcaatgacac catttttagt 360 tttatttcct gatagcaaaa ggaaaaaaaa cacccatccc tcaaaaaggc caaggtcccg 420 tccccctgtt gtcggtgatt tgtttgtctt tctgataggt tgaaaattgt gtaataaact 480 tgatgacgct gtcaatcttt tatactgca 509 <212> Type: DNA <211> Length: 509       SequenceName: # 584       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccccaaacag aaccatcttc gacagtgacc tgatggatag tgccaggctg ggcggcccct 60 gcccccccag cagtaactcg ggcatcagcg ccacgtgcta cggcagcggc gggcgcatgg 120 aggggccgcc gcccacctac agcgaggtca tcggccacta cccggggtcc tccttccagc 180 accagcagag cagtgggccg ccctccttgc tggaggggac ccggctccac cacacacaca 240 tcgcgcccct agagagcgca gccatctgga gcaaagagaa ggataaacag aaaggacacc 300 ctctctaggg tccccagggg ggccgggctg gggctgcgta ggtgaaaagg cagaacactc 360 cgcgcttctt agaagaggag tgagaggaag gcggggggcg cagcaacgca tcgtgtggcc 420 ctcccctccc acctccctgt gtataaatat ttacatgtga tgtctggtct gaatgcacaa 480 gctaagagag cttgcaaaaa aaaaaagaaa aaagaaaaaa aaaaaccacg tttctttgtt 540 gagctgtgtc ttgaaggcaa aa 562 <212> Type: DNA <211> Length: 562       SequenceName: # 585       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atggggcgat gcacaggtag gagctggcag tgcagggaag aggagacact ggtctgcagc 60 aacagcttct actaccagcc cttggggcac tcacccctgt gatcaagcaa tcattgtcaa 120 tgacaaagtg actattgaag ttataattgt attaaattaa tgctaataat ttggatattt 180 tattttattt ttggctgctc gggtaacttt agcccttaac caagcatatg tgggtttttt 240 tggttgtttt tttgtttttg tttttttttt ctttttcctt tttgggtaca gctgtaaaat 300 atttggatat aggaaatgtt gtgttattct tgcagccttg atattcaggg tggattgtaa 360 aatataaatt tttgtgagat ttcaaagatt aagattattt tgataacatt atttacagat 420 ttaaaagatg tggttatcac aagtctcgag ggggaaacta ctgcata 467 <212> Type: DNA <211> Length: 467       SequenceName: # 586       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agggagatgt tgttcactgc tggtatacag gaacactaca agatgggact gtttttgata 60 ctaatattca aacaagtgca aagaagaaga aaaatgccaa gcctttaagt tttaaggtcg 120 gagtaggcaa agttatcaga ggatgggatg aagctctctt gactatgagt aaaggagaaa 180 aggctcgact ggagattgaa ccagaatggg cttacggaaa gaaaggacag cctgatgcca 240 aaattccacc aaatgcaaaa ctcacttttg aagtggaatt agtggatatt gattgaaata 300 ggcagtgctt cagctctaag gatattagca acaatgataa aacttggcct tgaagaaatt 360 tacacaacta gttagaactt gttactattg taaaggaaga gtcaactgga aaattcaagg 420 agttaataaa atttgtttac ttggtcccag cttttgagag ataaatccct tatgaatccc 480 tggtctaaaa tactttccta cagctgtgta aa 512 <212> Type: DNA <211> Length: 512       SequenceName: # 587       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aactgcagtc ttctgctagc caatagcatt tacctgatgg cagctagtta tgcaagcttc 60 aggagaattt gaacaataac aagaataggg taagctggga tagaaaggcc acctcttcac 120 tctctataga atatagtaac ctttatgaaa cggggccata tagtttggtt atgacatcaa 180 tattttacct aggtgaaatt gtttaggctt atgtaccttc gttcaaatat cctcatgtaa 240 ttgccatctg tcactcacta tattcacaaa aataaaactc tacaactcat tctaacattg 300 cttacttaaa agctacatag ccctatcgaa atgcgaggat taatgcttta atgcttttag 360 agacagggtc tcactgtgtt gcccaggctg gtctcaaact ccaccaaatg tacttcttat 420 tcattttatg gaaaagacta ggctttgctt agtatcatgt ccatgtttcc ttcacctcag 480 tggagcttct gagttttata ctgctcaaga tcgtcat 517 <212> Type: DNA <211> Length: 517       SequenceName: # 588       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atactgtaag cggctccagg tgctgtgccc cgagcactca cgggacccca aagtgccagc 60 tgacgaggta tgcgggtgcc cccttgtacg tgatgtcttt gagctcacgg gtgacttctg 120 ccgcctgccc aagcgccagt gcaatcgcca ttactgctgg gagaagctgc ggcgtgcgga 180 agtggacttg gagcgcgtgc gtgtgtggta caagctggac gagctgtttg agcaggagcg 240 caatgtgcgc acagccatga caaaccgcgc gggattgctg gccctgatgc tgcaccagac 300 gatccagcac gatcccctca ctaccgacct gcgctccagt gccgaccgct gagcctcctg 360 gcccggaccc cttaaaccct gcattccaga tgggggagcc gcccggtgcc cgtgtgtccg 420 ttcctccact catctgtttc tccggttctc cctgtgccca tccaccggtt gaccgcccat 480 ctgcctttat cagagggact gtccccgtcg ac 512 <212> Type: DNA <211> Length: 512       SequenceName: # 589       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atatgcccca cgcaatattt ggaacactta tgtgaaaaat gatttgtttt tctgaaattt 60 acgtttctct ctgagtcctg taactgtccc cgaggggatt gagcagaagc tcgggtatga 120 gcccctgagg ttgactgccg gttatttttc tgtcctggga acagcctgac ccacctccct 180 gtctccatgt agccagtggg gggaggggga gacacagaac ctaccacagc caggggcgtc 240 cccatggcga ctgtggcccg gcccctcctc tcttgcctga ctctcctctc ttgcctgact 300 ctagacacta acttagttcc aggttcggtg ccctgttggt gctcctgttt ccaatagctt 360 aggtcccatg gtgggggagg aacctcaggg gctatgcagc ccccgccagc tgccctcaaa 420 tcccgtccag gccagttcca gattctaaac 450 <212> Type: DNA <211> Length: 450       SequenceName: # 590       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagtggcaca gctgcgaagt ctctacaaga aggctgggct tggcaaggag aaacgccatg 60 tcacctacgt tgtagccaaa aaaggtgtgg gccgcaaagt gcgccggcca gctggagtca 120 gaggtcattt caaggtggtg gactcaagga tgaagaagga ccaaagagca cagcaacgta 180 aggaacaaaa gaaaaaacac aaacggaagt aagcagagct gccaggctcc caggagagca 240 tggggactag gaggaagggt gtggcatggc tcagtctggc ccccttgatt accggcctag 300 cccctgctca catcacagct gtctgaagaa cagtgaggtg gagtgcctag aactcccgtg 360 gtggtcctga gcagagagga ggatgtcctc ctgcctgcct gaaggtctcc catgaaaaca 420 ctgctgaact gtgttgacac tcatgaccct ttttttaaac cgttaaaggg aagttcggtg 480 ttggagcgat actcaatgta gtcagtctac acctggacgt gtgggccact taagccct 538 <212> Type: DNA <211> Length: 538       SequenceName: # 591       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atggcttcca ggacagagca tgctcatttg ctggcggaca gttccagaaa cagaccctgt 60 tagtccttct acttacctgc tggatttttc aagcactaaa tttataactt tttgcaacaa 120 aataatgtgt aattttccat ttgggggcaa actctattct ggtgagcatt attaaatctt 180 gtttgtaaat atattgtctt tctcttaata tttgctctgg gtcaggaaga agctgttcac 240 ggtgtgataa tactctttag attgtgcttt cattattata gatgcatcat gtcttctgct 300 ttcacgtgtc tgggatgggg tcagaaatgc atcctccagc tgacagaaaa atccaggatg 360 agatcagaag gatactggtg ttttctgact tttacaaaat tacttgtttg ttttcattta 420 aaaaaaagca taaactatgt ttcttgttac tatta 455 <212> Type: DNA <211> Length: 455       SequenceName: # 592       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcgatggat gtggataccc cgagcggcac caacagcggc gcgggcaaga agcgctttga 60 agtgaaaaag tggaatgcag tagccctctg ggcctgggat attgtggttg ataactgtgc 120 catctgcagg aaccacatta tggatctttg catagaatgt caagctaacc aggcgtccgc 180 tacttcagaa gagtgtactg tcgcatgggg agtctgtaac catgcttttc acttccactg 240 catctctcgc tggctcaaaa cacgacaggt gtgtccattg gacaacagag agtgggaatt 300 ccaaaagtat gggcactagg aaaagacttc ttccatcaag cttaattgtt ttgttattca 360 tttaattgac tttccct 377 <212> Type: DNA <211> Length: 377       SequenceName: # 593       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttaatcccat gcatgccaaa cacttttcac acctaccgac ccattctcct tctgcttctc 60 ttgccctctt cttcacacca aaatatgatc gtgtccctgc cgcagaatat gtatttccta 120 attgctgtgg ccaagcgcct gtgtgccgaa tcgcttgctt ctgatcccgc tccgtgtaac 180 ctaagtgcgc tgcaggcaaa gcccaggcca cggctgcgtc actactgatg ttcacgatgc 240 cacacagtca cacacctaat tcattctcaa gtcggagcaa cacataccaa ccttgacctt 300 atcctcaagc tccagggcag cctggccgag cagcccctgc tccctcctgg agacccttgt 360 cacctcccga gctcctcctg gagacccctg tcacctcctg accaaccttt cccagggcgg 420 caccgatcac cgagcagccg tgcgtgtatc tcaaggaact aaataagatg acgctactcc 480 tcatagca 488 <212> Type: DNA <211> Length: 488       SequenceName: # 594       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccctggaca actccgagca gaagtgcatc gccatgtgca tggaccgcta catggacgcc 60 tggaacaccg tgtctcgcgc ctacaactcg cggctgcagc gggaacgagc caacatgtga 120 ccggcgagcg cgggccaccc caccctgttc atttccataa acgtgctttg agaggcgggg 180 tccgcatgta cgtactgcct gcccggggct taggagggtg gcaccggtgc tgggacacac 240 gggactgtgt cctcgccacc ccccgccctg ccccctgcca gccagtgcag cttggatctc 300 gggggtgtgg ggccctgtgc cttcctgaag tgctggcagc ccagtggcac ctccttcagg 360 cctttggggt attcccctag tgtgcccaag tcagcctcat attctgggcg gacagcttgt 420 ctggacttcg gagttggggg tggtcagaca ccacaggagc t 461 <212> Type: DNA <211> Length: 461       SequenceName: # 595       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtggtgcttt tggccattgg catgttcttc accgcctggt tcttcgttta cgaggtcacc 60 tctaccaagt acactcgtga tatctataaa gagctcctca tctccttagt ggcctcactc 120 ttcatgggct ttggagtcct cttcctgctg ctctgggttg gcatctacgt gtgagcaccc 180 aagggtaaca accagatggc ttcactgaaa cctgcttttg taaattactt ttttttactg 240 ttgctggaag tgtcccacc 259 <212> Type: DNA <211> Length: 259       SequenceName: # 596       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatatatggc tttgcttcac ctctgggtca tgattgttct gttgacttac acaccagaaa 60 tgcaccacga ccaaccatat ggcaaatgaa ccaagcccag ttgttgcagt gattggttgt 120 ctttttctag acttgggatc tgcaagaagg ccaattgcct aaaatttctg agaacagtgc 180 acaagattat tttatcacta caagctttta actttttaag ttattgtaca agtattctac 240 ctaaatcttc caatttcctt taaatggtaa gagtttctaa aacagacaat aatttaacaa 300 gctcagctct gctttatctg agtttagtgg tcctaatata tatgtagaga aagatggtgg 360 ggttgttcac ctctgtacag accatctgta tgttaggtga cattgattat gggttataat 420 cagggaaact aattgtattt agtgacaaaa ataaaaagtt ttttttttat aattcagtct 480 gcttttggat tttcatatat ttaactttgc aaaaagattt actttgtaca tgttacaggc 540 ttgattggtg 550 <212> Type: DNA <211> Length: 550       SequenceName: # 597       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacaaattac tgttcatcaa atctgaaata gtcacctcac agctcttcaa agaaaacctt 60 tgaaagattt atatctaaaa gctgtattta ctttaaaaga agtgcataat taccaaaatt 120 gtatgtacta ttgtacattt ttacaacagc attttcttaa acataatctg tgtttaatga 180 ttattgtcca ttgagcctgt actctgcttt ccataccaag taaatatgaa ataatctact 240 ttgcacataa cagaagaaac tataattact tggctgttgg agatttgtac ttgagtataa 300 atgtacacca gtttttgtat ttgtgaactc atctgtggga ggagtaaaga aaatccaaaa 360 gcatttaatg ttttgttttt gttctataaa gatatgaaaa tgtattttta tattatttta 420 cttatttgga atttacagag cacacctaag caattaggat ataacaaaac tacttaacca 480 tttttgcaac cat 493 <212> Type: DNA <211> Length: 493       SequenceName: # 598       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtcacattat gtcttagcat ctcactttat gaaaaaaagg agaaagatac caatctacag 60 agccctgctt gttgaagcac tagtttaatc aacaaaaaat tatggcaatc gggggtccat 120 tcatctattg cctttatgtt gttttttaaa agaaaaacca tgatgccttt gtatttgctg 180 gttgcacccc tgaaatcaat ccatatcatg tttgaatgcc atacattttg cacatgtact 240 gtacataagt aatgcatact gtattttata tgtgtgcaca tttatcatca gatcttttgt 300 acatagtggc agtattgtag ctgatcggga 330 <212> Type: DNA <211> Length: 330       SequenceName: # 599       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctcaggtgc caggaccatt gacaccagaa atggaggcac ggcaggctac acggaaaagg 60 gagcagaagg cagcccggcg gcaacgggag gaacagcagc agaggcagca ggagcaggag 120 gagcgtgaac gagaagagca gcggcgattt gccgccctca gtgaccgaga gaagagagct 180 ctggctgcag agcgccgact cgctgcccag ttgggagccc ctacctctcc aatccctgac 240 tctgcaatcg tcaatactcg acgctgctgg agttgtgggg catccctcca aggcctgact 300 ccctttcact acctcgactt ctctttctgc tccacacgtt gcctccagga tcatcgccgt 360 caggcaggga ggccctcttc ctgatctctt acagctctac ctggggccaa ctcagggacc 420 tgagagggca cattcacagc agccctaggt tttttcttcc ccgtgaaacc agagatgatt 480 tggaagatgg gggtgaagga cactcgggaa ctagggcaaa gacagggcta gaggtatgtg 540 gagctggtac tgtctctg 558 <212> Type: DNA <211> Length: 558       SequenceName: # 600       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agttgctaac atcatcttcc ttattttcag ccagtgctgt tactgcattt agcatggctc 60 tgacgaggca gtggagagtt cctgacagca tagcatactg ccttctgaca gactgggtta 120 agctaccaaa aatgacaacc agggattcaa aaaaaatttt tggtcattaa atcgaatgta 180 tattattact ttttaatttt ctaagtattt atcacaggac tttaacacca tatatttccc 240 tcccagtttt tctccccttt tggtttaata gttaaaacat tcttcataat tagtgctgta 300 catttgattg caaacaaatt ggtgatactt ctaaactata actataaatc tctagaattc 360 tgtgaatttc aacattattt gaagtagttc ttcagttata tttacatgtg ttgtaaatat 420 gtaaatatac ttttagctta ggaagtcttc cagaatacaa actactccca gttagatatc 480 agtga 485 <212> Type: DNA <211> Length: 485       SequenceName: # 601       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caggcaggag tttctctcgg tgactactat cgctgtcatg tctggtcgtg gcaagcaagg 60 aggcaaggcc cgcgccaagg ccaagtcgcg ctcgtcccgc gctggccttc agttcccggt 120 agggcgagtg catcgcttgc tgcgcaaagg caactacgcg gagcgagtgg gggccggcgc 180 gcccgtctac atggctgcgg tcctcgagta tctgaccgcc gagatcctgg agctggcggg 240 caacgcggct cgggacaaca agaagacgcg catcatccct cgtcacctcc agctggccat 300 ccgcaacgac gaggaactga acaagctgct gggcaaagtc accatcgccc agggcggcgt 360 cttgcctaac atccaggccg tactgctccc taagaagacg gagagtcacc acaaggcaaa 420 gggcaagtga ggctgacgtc cggcccaagt gggcccagcc cggcccgcgt ctcgaagggg 480 cacctgtgaa c 491 <212> Type: DNA <211> Length: 491       SequenceName: # 602       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acaagggccg cgggaacgag tgcgtgcagt accagcatgt gttacataga aatctcattt 60 atttggctac cattgcagat gccagtccaa ccagcacttc aaaagcaatg gaataatctt 120 tcaaaagcaa tagaataatc ttccatttgg ctgtcgtgag gagtaattga atgtaatcca 180 tctcttacaa aatggagaca gggtctttac caactcaact ggttaaaaca tgaatgaaac 240 ctctgtggct ctttcaaaac gtgaaaatgt gaagaaagct actaacttag ctgtattctc 300 atgtaaatat tttttaaata attaagcaaa tccctcaata agttgagccc aggtgtcctc 360 tttcctgaac ttggagcatg tttggataac aaagacatca ctgggatgtt caagtctact 420 ttttagtttc aacctgaaga ggaaactcag taggtgttgg gcaggaattg gtgagattcc 480 tgacttgata ccttgctaaa tggacatgta actgtgtgct ccttcctatc agtttgtaaa 540 tgtggtcccc ctgactgctg ttttcagatt g 571 <212> Type: DNA <211> Length: 571       SequenceName: # 603       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagacaattc gttatcttgc agcttcggtg tttacttgcc tggcaatagc attgggattt 60 tatagattct ggaagtagta ttaatgctca tcctgctgtg gctgttggct tcttagaaca 120 ccaaaccggg agagatttac tttgaacatt gtcagttgca gcaaaaattt actacacaag 180 attattcgaa gtgtatacgg actaaaagag gaagtgtttt agaatgagaa gagatactgt 240 gtctttattg tgtgtgtgtg agtgcaggtg tgtgtcttta ttatattgaa aagctgtcac 300 tcagacctgg tttgagatag aagagcattt tgtccttttg atagttaata gaaattgaac 360 cagagttttc ttatgtttgc ttgaacagtt gtgtaaatca tacaggattt tgtgggtatt 420 ggttgaatat ttgtaaacca ttccctagcc tacatattta ttactgaatt aactttcctg 480 ataaccattg cata 494 <212> Type: DNA <211> Length: 494       SequenceName: # 604       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacggaaaca gtttcatgtt cttcttagta ccatccatga acttcagcaa acattggaaa 60 atgatgaaaa actctcagag gtagaagaag ctcaggaagc aagcatggaa tcagatccta 120 agccatagac aggctaattg cccaccactc ccaggaatat tgaaatagct acatgaccat 180 aatgtgttta aaatgtggta tgctcttgag atatttaaag ttttggcagt aaaatactct 240 gtttttaagt atgaatgtat ttcattcata tttcctctca caaaggaaaa tgacttcagt 300 atagatttgt ttttattaaa atgcattttt tattcttaag tggtaggaag caacatccaa 360 aa 362 <212> Type: DNA <211> Length: 362       SequenceName: # 605       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttatcctcc acaactgcct ggagaacctc ggagaccagc agaaatctac cactgtcgaa 60 gacaaataaa atatagcaaa gacaagatgt ggtatttggc aaaattgata cgaggaatgt 120 ctattgacca ggctttggct cagttggaat tcaatgacaa aaaaggggcc aaaataatta 180 aagaggttct cttagaagca caagatatgg cagtgagaga ccataacgtg gaattcaggt 240 ccaatttata tatagctgag tccacctcag gacgaggcca gtgcctgaaa cgcatccgct 300 accatggcag aggtcgcttt gggatcatgg agaaggttta ttgccattat tttgtgaagt 360 tggtggaagg gcccccacct ccacctgagc caccaaagac ggcagttgcc catgccaaag 420 agtatattca gcagttcgca gccggaccat cgttcacact ctatgatgag gagattcaga 480 ctccacagtg tatat 495 <212> Type: DNA <211> Length: 495       SequenceName: # 606       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggacaatga aattgcccgc ctgaaaaagg agaataaaga actggcagaa gtagcagaac 60 atgtacagta tatggcagag ctaatagaga gactgaatgg tgaacctctg gataattttg 120 aatcactgga taatcaggaa tttgattctg aagaagaaac tgttgaggat tctctagtgg 180 aagactcaga aattggcacg tgtgctgaag gaactgtatc ttcctctacg gatgcaaagc 240 catgtatatg aaatgcatta atatttgact gttgagaatt ttactgccga agtttacctc 300 cactagttct ttgtagcaga gtacataact acataatgcc aactctggaa tcaaatttcc 360 ttgtttgaat cctgggaccc tattgcatta aagtacaaat actatgtatt tttaatctat 420 gatggtttat gtgaatagga ttttctcagt tgtcagccat gacttatgtt tattac 476 <212> Type: DNA <211> Length: 476       SequenceName: # 607       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgtctctgc gggattgttt caaccttttc actaaggaag aagagctaga gtcggagaat 60 gccccagtgt gtgaccgatg tcggcagaaa actcgaagta ccaaaaagtt gacagtacaa 120 agattccctc gaatcctcgt gctccatctg aatcgatttt ctgcctcccg aggctccatc 180 aaaaaaagtt cagtaggtgt agactttcca ctgcagcgac tgagcctagg ggactttgcc 240 agtgacaaag ccggaagtcc tgtataccag ctgtatgccc tttgcaacca ctcaggcagc 300 gtccactatg gccactacac agccctgtgc cggtgccaga ctggttggca tgtctacaat 360 gactctcgtg tctcccctgt cagtgaaaac caggtggcat ccagcgaggg ctacgtgctg 420 ttctaccaac tgatgcagga gccaccccgg tgcctgtgac acctctaagc tctggcacct 480 gtgaagccct 490 <212> Type: DNA <211> Length: 490       SequenceName: # 608       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcgctgatcc agtgacaatg tgccccctgc cagccggggc tcgcccactc atcattcatt 60 catccattct agagccagtc tctgcctccc agacgcggcg ggagccaagc tcctccaacc 120 acaagggggg tggggggcgg tgaatcacct ctgaggcctg ggcccagggt tcaggggaac 180 cttccaaggt gtctggttgc cctgcctctg gctccagaac agaaagggag cctcacgctg 240 gctcacacaa aacagctgac actgactaag gaactgcagc atttgcacag gggagggggg 300 tgccctcctt ccttaggacc tgggggccag gctgacttgg ggggcagact tgacactagg 360 ccccactcac tcagatgtcc tgaaattcca ccacgggggt caccctgggg ggttagggac 420 ctatttttaa cactaggggc tggcccacta ggagggctgg ccctaagata cagaccc 477 <212> Type: DNA <211> Length: 477       SequenceName: # 609       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcataggttc taacagcagg gtttggaaac ctgtctctaa gtaatgcatt acttctgtca 60 gaagtgtctt agggtggtta tctagttcag tactccaaat tattggggac cttgaggctt 120 aagtaagtat ttttctgaat ataatgctaa aggtaagttg cattcattta aactaataga 180 gcagacagaa ttcagcacta cttaatagtt tataaatcag tggtttcagt tgtatatatg 240 ttaggaaatg gagaggtata gagagagcag gttccatagc tcagcacttt taagtggaag 300 atcatttgaa tctcagtctt cagcctgcac tgatttgtag cctgcactgt cttactgatt 360 tacaaactga aatcactgag aaatgtcttt agttcagtga gaagaaacca gaacacttgt 420 tcctagtgtt gtgttgtttt ttttaagcaa attacttact gtatttttat ggcaggaggg 480 agaaaaagtg ttacaacggc ttctaatga 509 <212> Type: DNA <211> Length: 509       SequenceName: # 610       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaatggacat agcgtctgtg aagagaaatt tgatatttaa gcaacatttt tgaatgaaag 60 ttgtgaccat aaggtttaat ttcaaagttc cttttaaaag aggttaagga actgtgttac 120 cttttgtcct aagaaaaagg cttgaattta tgtaaatact ttgatcgatt gctaattttc 180 aaaggcttct taggtaggtt actacagtaa actgtaactc agtccacatt ttcatttagg 240 agctagacta ccataacaat gcttatgctg tttccaaggg taggttattt ttcattaaaa 300 gaagaatgaa tgcattttaa gtttaattct tcatagctga aagcacaaat ttaacggctt 360 cactggacag ttttccttag aaggtagttt tgtgtgactg tgactaaact atttta 416 <212> Type: DNA <211> Length: 416       SequenceName: # 611       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtgaatgtcc atattgtagt aagccaatta ccttaaaaat gtctggaagg aaacactgaa 60 ataagaatac aacatttcgg tgaagagctg gaaacttaaa aaattatcaa aaggaatttt 120 ggtatcatct tcagagaaaa aataaagcaa gaaatactaa catcaaaagg acaggtatga 180 tgatgcgata ataataaaca tctgcgtttg tctcttcact aagagtaaac tgggaaattg 240 taggccaaag tccagttgaa ctttctaagt ctgtgatccc cgtgctgact gtggaagtgt 300 atttatacca agatggagat cttgacttct tgaatatatc tggactggta aaatcttgat 360 gaggctcata aaatgagttt gggaattgtg tatagctgat tttttgtggg aaactgttta 420 cttcattcaa aggttcttga gactcttgat atttctgtct tctccttgtg ctttcctatg 480 gaaaaaatac atatatagtt tagtttgtta gacgtgagtt atccaagtat t 531 <212> Type: DNA <211> Length: 531       SequenceName: # 612       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cccggtgtgg ccacgagtcg ggttgcactg ctgtgatcca tcctcatctc ctaaagatgc 60 atcctgactt atctccacac ttgcacactg aagaatgcaa cgtcttgatt aacttgctta 120 aggaatgtca caaaaatcac aacattctga aattttttgg ttattgtaat gatgttgatc 180 gggagttgag aaaatgcctg aagaatgagt acgtagaaaa caggaccaag agcagggagc 240 atggcattgc aatgcgaaag aaacttttta atcctccaga ggaatccgaa aaataaattg 300 tattttcact cgatgccttg gctgagagaa gacctaaaga ctctgggttg atacctgaaa 360 gaatcctgtc ttatttggtc tccataatcc tttgaatgga aagtgacctg tgagagattg 420 aaccatggag aaatatgaaa accctggatt ctgagtattt gttgggcagg gcgtttagta 480 ctgtctcccc tttaccagca aacctgactt caccatgttt attcc 525 <212> Type: DNA <211> Length: 525       SequenceName: # 613       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctacttacac cttccatgca aaaaagtgtt caaaataaaa taaagagcct taactgggaa 60 gaaatggaca aaagccggtg cattcctgaa atagatgatt ccgagttttg tatccgcatt 120 ccgggaggag gtatcacaaa aacactctat gatgaaagct gttctaaaga aatccaaatg 180 gcagttctgc tgaaatttgt ttcagaaggg gacaacatcc cagatgcatt aggtcttgtt 240 gagtanctta atgagtggct tcagatactc aaaccactta gcgatgaccc cacagtatct 300 gcctcacggt ggaaaatacc aagttcttgg agattactct ttggcagtgg tcttccccct 360 gcacttttct gatctaattt ctgttttata ccttataccc aaaacactta ctaccaacac 420 agctgttaaa cattctatac aaaaaaattg tatgatctgg tattaggaaa ttactttcac 480 agtaaatatc aaagaaaaaa gattaagggt ctctttgcca tgcttttcat catatgcacc 540 a 541 <212> Type: DNA <211> Length: 541       SequenceName: # 614       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccgggcagcc gaagagtgtg gtaggtaacg gtcctcagcg caagggtcat ttcgtcgctg 60 ggaagggacg gccctcgccc gcggtgatgg tggttagcaa gatgaacaaa gatgcgcaga 120 tgagagcagc gattaaccaa aagttgatag aaactggaga aagagaacgc ctcaaagagt 180 tgctgagagc taaattaatt gaatgtggct ggaaggatca gttgaaggca cactgtaaag 240 aggtaattaa agaaaaagga ctagaacacg ttactgttga tgacttggtg gctgaaatca 300 ctccaaaagg cagagccctg gtacctgaca gtgtaaagaa ggagctccta caaagaataa 360 gaacattcct tgctcagcat gccagccttt aagattg 397 <212> Type: DNA <211> Length: 397       SequenceName: # 615       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actttgctgc ttattggcac cagggacaga gtttctagat acaattttat ggattggttt 60 taatttttat gagtttgtct ctgcagtgat tcggtttctc agagtctcat ggcatcatag 120 tttttccaga atgacacagt agccaccggt ggatgacagc ccacgggcgg cacagtcact 180 tctgcctgtt gctctgacac caacccaggc agctctgctg tggcttctcc tgggctctgg 240 cattagttgg tctgtgtcac attgtcagaa caggtggctg ctgtgtggtg ccatcgagtc 300 cctgctggtt ccccttgtcc tgggagggtc acccattgcc caaggaagtg catccacctg 360 gcaggtgacc tggaggagta gcttccccga ggacccccag gcttggcctg tgattgcgca 420 aacccacatt tcctaagcac actggacacc cttcgagtgt gggttttaac atccctgtga 480 gattgaatac ttgtgccaca cat 503 <212> Type: DNA <211> Length: 503       SequenceName: # 616       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgtcgccgc cgcggagaca aagatggctg cgagagtcgg cgccttcctc aagaatgcct 60 gggacaagga gccagtgctg gtcgtgtcct tcgtcgtcgg gggcctcgct gtaattctgc 120 ccccattgag cccctacttc aagtactccg tcatgatcaa caaggccacg ccctacaact 180 acccagtgcc cgtccgtgat gatgggaaca tgcccgacgt gcccagccac ccccaggacc 240 ctcagggccc cagcctggag tggctgaaga aactgtgagc acct 284 <212> Type: DNA <211> Length: 284       SequenceName: # 617       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agttctagta ttctggatca ccgtgaagga agtggaccta tagcctttgc ccacaagaga 60 atgacaccat cttccatgct taccacaggg aggcaagctc aatgtacatc ttatttcatt 120 gaacctgtac agtggatgga atctgctttg ttgggagtga tggatggaca gcttctttgc 180 ccaaaatgca gtgccaagtt gggttccttc aactggtatg gtgaacagtg ctcttgtggt 240 aggtggataa cacctgcttt tcaaatacat aagaatagag tggatgaaat gaaaatattg 300 cctgttttgg gatcacaaac aggaaaaata tgaacatgat attttatagc ttgggaagaa 360 acttgcagat gatatgtgct gcctttgctt cttatcattc atggcagatt gttagtgctt 420 tcaacatttc atttgaaatg ggagaagata aaatcacttg atgtaacctg gaaactatgc 480 tttacatggc aatcaaagcc ttttgatcat gtacattt 518 <212> Type: DNA <211> Length: 518       SequenceName: # 618       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtacctta ttagagcacc agaactaatt tgctaagtct tttgtttagt cctgcaagac 60 tgatgcttaa tacacagtct gttctcctgt gtctaggtca ggaactccag tttgcttttc 120 tgttttgtgt cctggtagca gctgttgagt aactttcatt ggaggttggg aaggaagtga 180 ggagaaagtg ttcttgttta gtgttttatt tcctataata ggatgctgcc taacccagtt 240 catctctatg tcctgttcac tgaatattcc gggtaattga aagaaaatat aatggatggg 300 ctccattaaa accagctcaa aaataaattc ttgtcagtaa agatttcttg tcaagatgtc 360 ttggattgca cttttgttga ggaaagacag tgtaaatagt taaagaatgt tgataaaatt 420 gaaacatttg gttgtggaat tgtgtgtggt tttagagggt ttct 464 <212> Type: DNA <211> Length: 464       SequenceName: # 619       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttaacatgca ccctcaagac ttcaaaacac tttttgaaac tatagagcgt tccaaagatt 60 gtgcttataa atggctgtat gatgaaaccc tggaagatag gtagcaacta gactgtcgtt 120 tttggtggag cggttcattt atttggaaac tatgacatga aaaccaaatt tgaaaactca 180 catcctttca gcagaaggta actgttcttg tcttgcacaa gccaggcaga tcatttctcc 240 taagctgata tcattggctt attggatgaa acagtgtctg ctattttatt cacaattgaa 300 taaaatgaaa acttcaatta attgtggatt tgatcagatt gaattcgttt tgtttcagat 360 tcctatttaa atatttcact tgtactgttg ctgatttttg catcttcttg aagag 415 <212> Type: DNA <211> Length: 415       SequenceName: # 620       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttctcagtt ctgtatgcac ttttatttaa cattattcat ataattctcc ccccaccact 60 ttatttatag atactgccca agtgagaagg agataataga tactttgctc tgaatttggc 120 atccagagta acatttctcc cctcactccc ttgctggtgt catagttatt agaatcagca 180 gcctcttaac taattgcggt ttcatggata tataaatgtt tcaagccatt attgctgaat 240 ggttctttag ttattaacct agacccaatt caaagaccag ttggatttat gatatttttt 300 atttgttctt gcagccaaag tgccagtttc tttaatatgt gaccaagaac acaaggagca 360 tccatatggc caaata 376 <212> Type: DNA <211> Length: 376       SequenceName: # 621       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagagtgagc atgaggagcg gcctgctggc cagggccggg atgagcccaa catgaaccct 60 aagcttgagg acccaaggcg ccccgacacc tccttcctgt ggtttacctc cccatacaag 120 accatgaagt tcatcctgtg gcggcgtttc cggtgggcca tcatcctctt catcatcctc 180 ttcatcctgc tgctgttcct ggccatcttc atctacgcct tcccgaacta tgctgccatg 240 aagctggtga agcccttcag ctgaggactc tcctgccctg tagaaggggc cgtggggtcc 300 cctccagcat gggactggcc tgcctcctcc gcccagctcg gcgagctcct ccagacctcc 360 taggcctgat tgtcctgcca gggtgggcag acagacagat ggaccggccc acactcccag 420 agttgctaac atggagctct gagatcaccc cacttccatc atttccttct cccccaaccc 480 aacgcttttt tggatcagct cagacatatt tcagta 516 <212> Type: DNA <211> Length: 516       SequenceName: # 622       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caatggcagt gacggcgttg gcggcgcgga cgtggcttgg cgtgtggggc gtgaggacca 60 tgcaagcccg aggcttcggc tcggatcagt ccgagaatgt cgaccggggc gcgggctcca 120 tccgggaagc cggtggggcc ttcggaaaga gagagcaggc tgaagaggaa cgatatttcc 180 gagcacagag tagagaacaa ctggcagctt tgaaaaaaca ccatgaagaa gaaatcgttc 240 atcataagaa ggagattgag cgtctgcaga aagaaattga gcgccataag cagaagatca 300 aaatgctaaa acatgatgat taagtgcaca ccgtg 335 <212> Type: DNA <211> Length: 335       SequenceName: # 623       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggctcaggag ccagtatcaa gctctcagtc aagatccaaa cagtctttca aacctagatc 60 aggatctccc caataatatg atttaccaag tcgccattaa gtctcttcct caagactggc 120 tgtggtgtga aacctggtgt gatgatgaat ccaaacaaag agccaaaaca attgatctgt 180 gcaataatcc caaaacaaaa gaatccaaac taaaagctgc tgccagaatt gtcccagaat 240 gggtggagta tgatgctgag ataagacaac tattagatca tcttgaaaac aagaagcaag 300 atacaatttt gacacatgat gaactctagc actggtgtat atgagaagga aggcgaaagc 360 atgacaggaa acctgccgcc tgctggggaa gtctggagcc cctgctgaga cgatttggaa 420 g 421 <212> Type: DNA <211> Length: 421       SequenceName: # 624       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccctcacacg tgcgcaggaa gatcatgtca tccccgctct ccaaggagct gcggcagaag 60 tacaatgtcc gctccatgcc catccgcaag gacgacgagg tccaggtagt tcgaggacac 120 tacaaaggtc agcaaattgg caaggtagtc caggtgtaca gaaagaaata tgtcatctac 180 atcgagcggg tgcagcgtga gaaggccaac ggcacaactg tccacgtggg cattcaccca 240 agcaaggtgg ttatcaccag gctaaaactg gacaaggatc ggaaaaaaat tcttgaacgc 300 aaagccaagt ctcgacaagt tggaaaagag aaaggcaaat ataaagaaga acttattgag 360 aaaatgcagg aataaataga acctgttgtg caaccacggt ttaaccggag attttgaggc 420 tagggtgtgt ttctttcgaa cttttcggaa tgtctggaac atttcatttc ctgttttgtt 480 acctgtgcct ctgtaaatct 500 <212> Type: DNA <211> Length: 500       SequenceName: # 625       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatgttggtg tagctagtcc cgcgacattg agctcctctg catgaagaca ctgggctcct 60 gcatccagct gtttttattg caaactagct cctttctccc acactgggaa ctttagtcca 120 cgaggctgtc accaccctgg tagcactggg ccaggctttg tagctcctgc agcagctctg 180 ctacgtcatc gtgctccact ccagcatcca tgaagctggc ccagcgccgc aagtcgagtt 240 tggtgaggtc tctggccaag gcttccaggg tctggtgcag ggacgaagag gaacacagtg 300 ccccaaacac tgggatgctc tccactgctg tggagggaga ggaaacagag acctgtagat 360 ggatgattat tctgccctgg gactcgccaa actgataagg aagtccaacc ttagtagact 420 tgattgtaaa ctcaacaaat ttggtgtatt gtccccttag taca 464 <212> Type: DNA <211> Length: 464       SequenceName: # 626       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gatacaagcc aaacgtgctg ctaagaaaca agaattcgag aggagaaaac aggagagaga 60 agaagcccaa aggcagtaca aaaagaagaa aatggaagtg tttaaaatac tgaacaaaaa 120 gactaaaaag ggccaaccaa acttgaatgt acaaatggag taccttcttc aaaaaataca 180 agaaaaatgt taaacatttt gttcctacag gttaaaatat ctgctgccta ttaggttctt 240 ctgtgacatg tgcctcccag cagtgaacta aatttgtcga cataaactgg attgctaaac 300 tatgctaaat ataagatgtt cacatatttt tattatggta aaaaattttc taaatatgtt 360 ctacatgttt cttatttatt tgcctctgaa ggaaggttgg cctgaagaac tgaaagaacc 420 tcttattttg caagacaggc ccaagcatgt aatacttt 458 <212> Type: DNA <211> Length: 458       SequenceName: # 627       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagagtccta tcttactgtg acttaaagtt tgatggagag aaagctgtag gatccataaa 60 ttctaccagg aaaccagggt cttcctgttc ctagcactga gaatgggcac ccagtggtcc 120 aagaacactt tctgggctaa catagtcctc acacagggct gagaaagaaa gtgtctcctt 180 tcctggaaag cacatgtaaa agttaagggc ctgaatctct tctaaaccaa taattgacct 240 ctaggcaccc accgtaatac tgctaccttc agggcagaag acactgctct ttgtaaccca 300 gccaccacca aaaagcaaac agaaagaagg aaggatggtt aagccattgg ataatactga 360 atctgtttcc ctaagtgact taaccttaga gcaagcacaa catccaggtt aattttttgt 420 aagatttctc cttttattat tgccctcatc atagttcctg attgtc 466 <212> Type: DNA <211> Length: 466       SequenceName: # 628       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaagtgtctt ctttggacca gatttcatca ctgtcacaaa ggaaaatgaa gaattagact 60 ggaatttact gaaaccagat atttatgcaa caatcatgga cttctttgca tctggcttac 120 ccctggttac tgaggaaaca ccttcaggag aagcaggatc tgaagaagat gatgaagttg 180 tggcaatgat taaggaattg ttagatacta gaatacggcc aactgtgcag gaagatggag 240 gggatgtaat ctacaaaggc tttgaagatg gcattgtaca gctgaaactc cagggttctt 300 gtaccagctg ccctagttca atcattactc tgaaaaatgg aattcagaac atgctgcagt 360 tttatattcc ggaggtagaa ggcgtagaac aggttatgga tgatgaatca gatgaaaaag 420 aagcaaactc accttaaaat aatctggatt ttctttgggc ataacagtca 470 <212> Type: DNA <211> Length: 470       SequenceName: # 629       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttactgtgc tttggcatag cttctacatc acagcaagtg acttctcaga ggggaaaagc 60 caagctccag acaaggagtg ctgttagccc aaggggaaga gctaatagat acataggccg 120 taagcacagg gctgtacaca gatcctttat tggcatctgc atgagaggcc tagaaatcgg 180 atgttagaag ctaggaatca tggctctgag cgccttgcat acaggagata ctcactgata 240 ctaaatcaag gcatgtaaac aatactgggt aaatcatacc taccagaata aagagtaaca 300 ttcagagctt ttcttttatc tgttatttta aatgttactc catatttcaa aagtctgcac 360 gtatgaaatt gtgtcttatt tctggttttt agagcctaag aaagatactc attcttaatt 420 cctattta 428 <212> Type: DNA <211> Length: 428       SequenceName: # 630       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agttaacaca tcagctggac ctatttcccg aatgcagggt aacccttctg ttatttaaag 60 atgtaaaaaa tgcgggagac ttgagaagaa aggccatgga aggcaccatc gatggatcac 120 tgataaatcc tacagtgatt gttgatccat ttcagatact tgtggcagca aacaaagcag 180 ttcacctcta caaactggga aaaatgaaga caagaactct atctactgaa attattttca 240 acctttcccc aaataacaat atttcagagg ctttgaaaaa atttggtatc tcagcaaatg 300 acacttcaat tctaattgtt tacattgaag agggagaaaa acaaataaat caagaatacc 360 taatatctca agtagaaggt catcaggttt ctctgaaaaa tcttcctgaa ataatgaata 420 ttacagaagt caaaaagata tataaactct cttcacaaga agaaagtatc gggacattat 480 tggatgctat 490 <212> Type: DNA <211> Length: 490       SequenceName: # 631       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcatctaac atcatcatct tctaatgtgt tggagatttt catttcaaat atatttttta 60 aattactcta ttttccaaaa cacgtaatgc atttttctcg aaaatacctt actgtaaaaa 120 taactgtcgc gtacacatgt gtgaagtagc tagaacatac tgaatttttt ttgtactgtt 180 ggactctatt cagtgtcatg tcctatatct gatcaagtta tcaaggagat aattctagaa 240 tgaaaaagaa aatcctcttg ttggaaacaa aagacgtttt atatgtgcag tatgacaaag 300 aggagtttca gagacaactt tgaatccttg tcagcctgga gaccagcacc agaggaatct 360 acaaggcaaa ctcccatata tttgcttccc ccaaattgct gcccctacag actcaaagct 420 ctttttcttt gttttgttgt ttctctaaaa atttactgtt ctttgtcgat gctatataag 480 ccagggagtt ctaagacgcc agctctttga gatttgctca ttcccctgta tttcccacat 540 atatat 546 <212> Type: DNA <211> Length: 546       SequenceName: # 632       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttatcagat gagcctgtag aagcaaaaga agattacact aagtttaata ctaaagattt 60 gaagactgaa aagaaaaata gcaaaatgac tgcagctcag aaggctttgg ctaaagttga 120 caagagtgga atgaaaagta ttgatacctt ttttggggta aaaaataaaa aaaaaattgg 180 aaaggtttga aactttgaaa ataaaatcta gcaaaaatat ttgcttttta catgtttcag 240 tttgtccttc ctgactgtta atgactacct ttggttgggg gaaggaagag gccaatttca 300 tgttctctta aacatttctt tgcatttggt ttttgtgttc ctgaacaaaa tatgggaaag 360 tgtctaactt catggctatg gccttttgga gtctcatctg acataatgaa a 411 <212> Type: DNA <211> Length: 411       SequenceName: # 633       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tggaattgga ggccgggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccaa 60 ggtgggtgga tcacctgagg tcaggagctc gagaccagcc tggccaacat ggtgaaaccc 120 catctctact aaaaatacaa aaattagcca ggtgtgatgg tgcatgcctg taatcccagc 180 tcctcagtag gctgagacag gagcatcact tgaacgtggg aggcagaggt tgcagtgagc 240 cgagattgca ccaccgcact ccagcctggg tgacagagcg agacttatct cataaataaa 300 tagatagata ctccagcctg ggtgacagag cgagacttat agatagatag atagatagat 360 ggatagatag atagatagat agatagatag ataaacggaa ttggagccat tttgctttaa 420 gtgaatggca gtcccttgtc ttattcagaa tataaaattc agtctgaatg gcatcttaca 480 gattttactt caatttttgt gtacggtatt 510 <212> Type: DNA <211> Length: 510       SequenceName: # 634       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gctgccactg cagaggtttt tacctcgacc tccaggtgag aaaggacctc caagaggtgg 60 tggcagggga ggccgaggag gaggaagagg aggaggtggc agaggtggtg gcagaggcgg 120 tggttttaga ggtggaagag gaggtggagg tgggggcttc agaggaggaa gaggtggtgg 180 tttcagaggg agaggacatt aagtgaaaca gttgacagac atcaccagtt gacttctgca 240 ttaacctgca tgatctgttt ctactatgga ttggaaactt gtttcttgaa caagtcttga 300 agatcttggt cattttatga caatggatct aaaatgtcag catcatgcaa agtgcaacgg 360 aatagtgaat tttgctctaa aagagcatga acaagtcttt ctaatgtttt gtacagtgcc 420 tggc 424 <212> Type: DNA <211> Length: 424       SequenceName: # 635       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacaggcata ggaaatcaca agggtattga ctggggaagt gataagtgtc catgaaatct 60 ttacaattta tgtttagaga ttgcagtaag gacaggcata agaaattata aaagtattaa 120 tttggggaac taataaatgt ccatgaaacc tccacaatcc atgtttttct gccatggctt 180 cagccagtcc ccccgtttgg ggtccctgac ttcctgcaac aatgtcctgc aggaaaagtt 240 ttttctttat atccagtttt tacatgatga attatttccc aatatttcat agtttatgag 300 gctgaattcc tcttgaattt attaaatgct tccttcacat cctctgtgat gatcatgttt 360 atttactgat aaaactcaat acctagaact gcacctagct catgatggta cctaataaat 420 acttcaatga aatgatgtgg tgatgcatgc ctatagtttt agctacttgg gagggtggcc 480 tgagccca 488 <212> Type: DNA <211> Length: 488       SequenceName: # 636       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaggctgggg gcttatgttg tggtcggggg tccccgcctc cagccccccg ctcccacccc 60 cgagcctacc ctttgtctcg catgagtgca atatttcatt cccggtggtt gtctggggag 120 gtggttggac gaggtcctgc ttgaggctcg gggatcagaa cgatgtcaag tgaagaaaaa 180 tgcacggggg catgctgagc cactggagtt ccagagaggg ccgaggaggg tgcagccacg 240 gaggttggat cctctgctcc gccgcctcgt cctcgtcccg cttctgctgg gttccgcttt 300 gtccctggtt ttttcctttt tttttctgtg tgcgtgcgaa tggtgcggcc cctcccctct 360 caccgtggtt aacgtgacga aggcacgatt cctgtaaa 398 <212> Type: DNA <211> Length: 398       SequenceName: # 637       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aagctctaat ggaccttttt gaagagaagt tgtggcttat gtggagttta catgggcctc 60 tgatggaaga aagctaatct gtttagtatt tgtgcatttt actaaaatgg cagcttaaag 120 ttgtgtatct gctattgtga tgccaatgcc ggtgttttaa gtggaaaaaa aatgacctct 180 ttgatttgtg ctgtgtacac aagatttctg gaaaagtaaa gaaaaaccct ttttatggct 240 cacacagctt aagagtagct gtctctcaaa cgtgcgctca cagttga 287 <212> Type: DNA <211> Length: 287       SequenceName: # 638       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atcttcttca aatttaacac acctcaacaa ccgaagaaga aataaaattt agttattgct 60 cagataaaca tacaacttcc aaaaggcatc tgatttttaa aaaattaaaa tttctgaaaa 120 ccaatgcgac aaataaagtt ggggagatgg gaatctttga caaacaaatt atttttattt 180 gttttaaaat taaaatactg tgtacccccc cccccccatg aaatgcaggt tcactaaatg 240 tgaacagctt tgcttttcac gtgattaaga ccctactcca aattgtagaa gcttttcagg 300 aaccatatta ctctcatgat acttcattaa tctccatcat gtatgccaag cctgacacat 360 ttgacagtga ggacaatgtg gcttgctcct ttttgaatct acagataatg catgttttac 420 agtactccag atgtctacac tcaata 446 <212> Type: DNA <211> Length: 446       SequenceName: # 639       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacactaaga cattatttca ctatttatag cttttccttt tttttatttg agaaggagtc 60 ttgctctgtt gcccacattg gagtgcagtg gcacgatctc agctcattgc agcctccgcc 120 acctgggttc aagcaattct cctacctcag cttcccgagt agctgggatt ataggcaccc 180 accaccacac ctggctaatt tttgtatttt tagtggagac ggggtttcac catgttggcc 240 aggctggtct ggaactcctg agctcaagtg atctgcccat ctcagcctcc caaagtgctg 300 ggattacagg tatgagccac aacgcccagc catcatttat ctttttcact cattttttca 360 tgagtatgca gaggagtttt caagaggcta tctggtgtga tattgtaata ggctgaatgc 420 aaaagcagat acaagattcc agctttcgtc tgtcatcaga cattgaagag atttggagaa 480 atgtaaagca gcagtactct tctcacta 508 <212> Type: DNA <211> Length: 508       SequenceName: # 640       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atcacttcga ccacatcaag gctgtcattg gatccaagtt catcgggatt ggtggagatt 60 atgatggggc cggcaaattc cctcaggggc tggaagacgt gtccacatac ccggtcctga 120 tagaggagtt gctgagtcgt ggctggagtg aggaagagct tcagggtgtc cttcgtggaa 180 acctgctgcg ggtcttcaga caagtggaaa aggtacagga agaaaacaaa tggcaaagcc 240 ccttggagga caagttcccg gatgagcagc tgagcagttc ctgccactcc gacctctcac 300 gtctgcgtca gagacagagt ctgacttcag gccaggaact cactgagatt cccatacact 360 ggacagccaa gttaccagcc aagtggtcag tctcagagtc ctccccccac atggccccag 420 tccttgcagt tgtggccacc ttcccagtcc ttattctgtg gctctgatga cccagttagt 480 cctgccagat gtcactgta 499 <212> Type: DNA <211> Length: 499       SequenceName: # 641       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttgtagcca tctttgctgt gccacttatc ctgggacaag aatatgagga tgaagaaaga 60 ctgggagagg atgaatatta tcaggtggtc tattattata cagtcacccc cagttatgat 120 gactttagtg cagatttcac cattgattac tccatatttg agtcagagga caggctgaac 180 aggttggata aggacataac agaagcaata gagactacca ttagtcttga aacagcacgt 240 gcagaccatc cgaagcctgt aactgtgaaa ccagtaacaa cggaacctag tccagatctg 300 aacgatgccg tgtccagttt gcgaagtcct attcccctcc tcctgtcgcg tgcctttgtt 360 caggtgggga tgtatttcat gtagaaggtg gaagaaggct gctatgactc tttggatggg 420 <212> Type: DNA <211> Length: 420       SequenceName: # 642       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcttggtcca gagatcttca gcctcgttca cattcttatg atagaagacg caggcatcga 60 tcaagcagta gctcttctta tggctccaga aggaaacgaa gtcgaagtcg ttcaaggggt 120 cgagggaaat cctatagagt tcagaggtct aggtcaaaaa gcagaacaag aaggtccagg 180 tcaagacctc gtctccgttc tcatagtcgt agcagtgaaa ggtccagtca cagaagaacg 240 cgtagtcggt ctcgggatag agaacgacgt aagggcagag ataaagagaa aagagaaaag 300 ggagaggata aagggaagga caaggaatac ataacatcaa acgtgggaat ctggaaacat 360 caaagctgga tttagaacat cttgccacca gctgaacagg ccaaagccag actacagctg 420 <212> Type: DNA <211> Length: 420       SequenceName: # 643       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aaggcttatt ttgcttcaca gtaaaataac agctctatta ttattcagca aggccaaaga 60 cttttgagaa tgtgtatgga aaattctttt tgtgcatttg agggcaaaat tcaggccatc 120 ttcttataca tatactatca aattatgttg tgtgcattag aaatcagttg cttgatagta 180 gctattaaac ccaatattgc tgatagtatg ctaatatcct aaaacttaaa tattgcatat 240 ctatgaatgt taaattcaga atatctctaa aacatggaaa attgatgttt caataaaaag 300 ggagacattt tattattttg ccttactaat gattttgcag ctctgttttt ctgcacactc 360 aatagaaaat attgtgggtc tgagatgccc tttgaaaatg cctgaaagaa aacatgggct 420 actacattat gttaatgttt tgtaatgtcc ttttaatgag tggtgacata aaagggctgc 480 tttgttgtcc tgatatggc 499 <212> Type: DNA <211> Length: 499       SequenceName: # 644       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacttgggct catatgacat aaggatgatc atctctggca caacagctca cttttcttcc 60 aaggataagt tgcaagaggt gaaactattt tttgaatctc ttgaggctca aggatcacat 120 ctggatattt ttcaaactgt tctggaaacg ataaccaaaa atataaaatg gctggagaag 180 aatcttccga ctctgaggac ttggctaatg gttaatactt 220 <212> Type: DNA <211> Length: 220       SequenceName: # 645       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tatctgggca tagtagtgtg tgcctgtaat cccagctact tgggaagctg aggcaggaga 60 attgcttgaa cctgggaggt ggaggttgca gtgagctaag atcgcaccac tgcactccag 120 cctgggtgac agagcgagac tccatttcaa aaaaaaagac tgaaacaagc ttgtgctaag 180 atggaaaggg ctgcttctaa cagatgtggt ttgttgcttt agttgttgaa gcaaaaatac 240 tgagttgtta tgtttatgtt atcaccccac cactacctcc atggttgttc atttaggatg 300 cttctaattc agccactgtg aaccattata aaggttttat tgccatgttg aaaatgttta 360 taatatggca aaaaggggca tcaaatagaa gatttactat tattccagcc atgtaaaaat 420 atgtgcacat atggatgtat gttgaaagtg gatgatg 457 <212> Type: DNA <211> Length: 457       SequenceName: # 646       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcctgtacct ttaaccttta gtctgtcaag gaaaaccctt aggacctctg aatcaagagg 60 actgagtttg tgggtgaacc ttgaaggtgc tctttctgct acaagggccc tgggagatag 120 catggacgtg cattgagaag ccagcctcag accttagctt gaagcagctt gaggccagac 180 ctactgtagc ctcagcatct tgctaggagg catggaagtg atctatcctg ccaggaggcc 240 tcagagtgat ctgtcctgcc aggaggtgtg agagtgatct gtcctgtgag gcatttaggg 300 gctttcagga atttagtaaa aggtggagta tgcctttcca gtatcttcca tcttcctttg 360 tatacttgtc cttcctccca tttcctccct ttggcccgag gtaggaggat ggagggaggc 420 tgctactcta ccacttcctg tgtgcctcta ctgtggcctc aaccctggca attatagcta 480 ctcccatccc ttacctgggc atgtgtgagc ccttctcact ggattttata cccttgtgtc 540 tgtgt 545 <212> Type: DNA <211> Length: 545       SequenceName: # 647       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtggtagttc caatgccaag gagcctaaga cgcgcgcagg cggtttcgcg agcgcgttgg 60 agcggcactc ggagcttcta cagaaggtgg agcccctaca gaagggttct ccaaaaaatg 120 tggaatcctt tgcatctatg ctgagacatt ctcctcttac acagatggga cctgcaaagg 180 ataaactggt cattggacgg atctttcata ttgtggagaa tgatctgtac atagattttg 240 gtggaaagtt tcattgtgta tgtagaagac cagaagtgga tggagagaaa taccagaaag 300 gaaccagggt ccggttgcgg ctattagatc ttgaacttac gtctaggttc ctgggagcaa 360 caacagatac aactgtacta gaggctaatg cagttctctt gggaa 405 <212> Type: DNA <211> Length: 405       SequenceName: # 648       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggatcagctc aagaccatgg gttggagaat taatgttcac acttctattt ggagactttg 60 aatcccctct acacaagcta cgcaagtcaa gttagttgcc aagaaagcac agatgacaac 120 ctattaatgc tgtgagaatg tttctagatc agtgcatgga tggctccatt gctctacggg 180 ccattgtgtc tgagatccca gtctttgagg agaaaaaaaa caatggttaa aaaggcattg 240 gggaaatatt ttgagtttgg gggtgtactt tgccacccca ttattgggga gctgtcacca 300 cgaatgttcc caaacttagc aacagcggca aactactggg ccaagatgag caaccccaca 360 tttttgggat ttaaagctcc tgatgttata ccaggatcaa ccatcacact ccctttgctt 420 caaatggcgt ctaccccgta agatcttgag gg 452 <212> Type: DNA <211> Length: 452       SequenceName: # 649       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actggaaccg cgagctgctg aagcgggagc tgggcctggc cgagagtgac atcattgaca 60 tcccgcagct cttcaagctc aaagagttct ctaaggcgga agcttttttc cccaacatgg 120 tgaacatgct ggtgctaggg aagcacctgg gcatccccaa gcccttcggg cccgtcatca 180 acggccgctg ctgcctggag gagaaggtgt gttccctgct ggagccactg ggcctccagt 240 gcaccttcat caacgacttc ttcacctacc acatcaggca tggggaggtg cactgcggca 300 ccaacgtgcg cagaaagccc ttctccttca agtggtggaa catggtgccc tgagcccatc 360 ttccctggcg tcctctccct cctggccaga tgtcgctggg tcctctgcag tgtggcaagc 420 aagagctctt gtgaatattg tggctccctg ggggcggcca gccctcccag cagtggcttg 480 ctttcttctc ctgtgatgtc ccagtttccc actctgaaga tcccaacatg gtcctagcac 540 t 541 <212> Type: DNA <211> Length: 541       SequenceName: # 650       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agccaagccc tctgaggcat gatgggaccc cggtgccagc caggagaagg cccctgggac 60 acgggtttgg cctcgcgcac cctggcatga tgcaggagct gcaagcccgt ctgggccggc 120 ctaagcccca gtgactgaga cccggtgctc tgggagccag gccctgagtg ggtgccagaa 180 ggcttgctcc aatgccactg agccctgctc cctctgccac tgtggacaca tcctctccac 240 cctctgggcc tcagtgtctt gatgtatcat tcatggagca ggcaaaacca gacgtctggg 300 aataccgtga acttaaggag tctgattctc cgacacaggc tggtggacca cctaccccac 360 tgagaccacc tctcagggtg cctgccctgg ttcctcccca gcctgagtca gctgtctgga 420 ctgcaaggag gctgggc 437 <212> Type: DNA <211> Length: 437       SequenceName: # 651       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caggattgga tcaacagcct cctctcttgg ggactctcaa gagcctgtgt tcatctagaa 60 gtagtagttt gattctggtt tccctcatac agtgtgtcct ccgtctctgt gcagctccgt 120 cattaccata ggggacttgg ttttagactc tgatgaggaa gaaaatggcc agggggaagg 180 aaaggtgagt gggaaggagc agaaagctgg gaaaggggat gggtagaaca agactgagaa 240 atccacatgc ttcagaattc agagggttca gggaatggtt tcggatagta ggctctccct 300 <212> Type: DNA <211> Length: 300       SequenceName: # 652       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaaatgaacc acctcaacat aaaaatgcta aaatacctaa gaaatcaaat gattcacaga 60 atagattgta cggcaaacta gctaaagtag caaaaagtaa taaatgtact gccaaggaca 120 agttgatttc tggccaggca aagttaactc agttttttag actataaatt tgtgtcttat 180 atgctttagg tttatgcatc tataaaccat tcaccaaaga catgcttaat ttttaagaga 240 tcaaggtgta aattatgatg atttattatt ttggtctaca gtgtatgtaa ggttagtatg 300 ttaagcactg tttttgactt tttaaaaata ccttagatgc aaatttatag gagaaaaaac 360 actttcagat aagaggtgtt tgctgggatg gaagaactac ctggcatgta agaaatatcg 420 tcagtcgtcc taatgcatat t 441 <212> Type: DNA <211> Length: 441       SequenceName: # 653       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atatggccat cgtgtcagca gagagagtct ctgtacacag ccccgtgaac cctgaggagt 60 ggagtcatac acgaagggcg tgtggccatc gtgtcagcag agagagtctc tgtacacagc 120 cccgtgaacc ctgaggagtg gagtcatacg cgaagggtgt gtggccaggc tgcagagctg 180 cgtgccgttt gtgtccgagc atcacgtgtg gctccagccc ttatttctgc cagtgtagac 240 acctctgtct gccccactgt cctggggtcg ctcttgggag gcacaggcat gggtgtgtct 300 ggcctcattc tgtatcagtc cagtgtgttc ctgtcatagt ttgtgtctcc caggcaggcc 360 atggtagggg cctcgcaggg gccattgggg agcacagggc caggctgggg tgaggagagc 420 tcccctgttt tctgtttaat tgatgagcct gggaaaggag tgtgttctgc ctgcc 475 <212> Type: DNA <211> Length: 475       SequenceName: # 654       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taattgagtc agatgctaac gagatactgc aggcataact gctgtttttc tgacaactga 60 ttgtgaaacc ttaaaacctg catacctctt cttacagtga ggagtatgca aaatctggaa 120 agatattcta ttttttttat ataggtagat aggatcgcca tttatttc 168 <212> Type: DNA <211> Length: 168       SequenceName: # 655       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atgtactctt actgagatac cctctcaccc caaatgtgta atggaaaatt tttaattaag 60 aaaaacttca gttttgccaa gtgcaatggt gttgccttct ttaaaaaatg ccgttttctt 120 acactaccag tggatgtcca gacatgctct tagtctacta gagaggtgct gccttttcta 180 agtcataatg aggaacagtc ccttaatttc ttgtgtgcaa c 221 <212> Type: DNA <211> Length: 221       SequenceName: # 656       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggtgggagtt gatcctccca cccagtctgc ccctggtctc tgcccatcca atcagagccc 60 accctcctgg aagagacccc cgtgttcaga gtgctggcag ccctgcacgt gtccagggac 120 actgcatttc aaagaaccac tgagtgggtg agctaccttg ggcaaacccc ccactcctga 180 ctctgactgc cacgtgggtg gcccgacctc tgacctgctg tcatcataga ggtagaaagc 240 aaacaatctg gggctcagca cacctggggg tgctcccact cattcagtgt gtggggcccc 300 tgagcagagg ctgggcattg ccactagaac ctgagctcct agagagcaag gacctgggtg 360 gcctcgctta ctgttccagc ccaggccgag cacagggcct ggctcgtggc aaaccttgaa 420 taa 423 <212> Type: DNA <211> Length: 423       SequenceName: # 657       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttcaaaaagc tctcagtctg tgtcatgtaa ggacatgctt atgaaatgtg agagaggctc 60 gccactaagt attctaaata cttttcaatg gcttttctaa caacctcagt agtaatttgc 120 tgagcatcat ccagaccatt aatagaatca gcaaagcact ggaatttcac actttaatga 180 taatattcca catagtctat gggcaaatat tttcaacatt tccaattttt aaagcttcag 240 aattgaagcc aaacaaatta ataaataatt gttttaatta ctatttaaaa actcaggttt 300 agattgttta aaattagttg cttttgatac tcagctgtca tgtttataat tcaaacatgt 360 agtaaacata tgtaggtaag gttgtttttt tggagatgtt gcagctcaaa tttcagtcca 420 catatgaatc atcagtgtat tttccataaa gtgattcggg catatttgtg tgaaaacctc 480 agttctgtca cttcttac 498 <212> Type: DNA <211> Length: 498       SequenceName: # 658       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcaagggcaa atacaccctg accccacgag catgtggccg ccagccccag gagcccagcc 60 tcttgagatg ctcccagggt ggacccacac attgtctcca ctccgaagca gttgctattg 120 gtccaagagg atgctcgggt agtcttcggt ggctgcagga gagcgatgct gcgcctctgc 180 ccctctcctg ccacctggct gcccacagag ctctccaggg cagaagtcgc ggtgggctca 240 gtgggtgccc tgagcggggt ctctcagact gacgtcaggc cttggtgggc tgcactctca 300 cctggaggct ccggggaagc atctgcctcc aggaccattc aggctgttga caagtcaact 360 cctcatggct gtaggactga ggttcccaag tccttgtccc tggtcctgtg gtccctccac 420 cttcaaacca gcaatggt 438 <212> Type: DNA <211> Length: 438       SequenceName: # 659       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aggtctacaa acactttgct tcctccaacc tcaacctgaa cagcgcctac aagctgctga 60 gtgctgatgg gcagtcagaa cccccataca ctacctggaa gatccggacc tcaggggagt 120 gcaggcacac cctggattac atctggtatt ctaaacatgc tctaaatgta aggtcagctc 180 tcgatctgct cactgaagaa cagattggac ccaacaggtt accttccttc aattatcctt 240 cagaccacct gtctctagtg tgtgact 267 <212> Type: DNA <211> Length: 267       SequenceName: # 660       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aatgcgaatg atcctgaagc ctcaaagttt catgatattg atgatgttaa gaagttcaaa 60 ccgggttacc tggaagctac tcttaattgg tttagattat ataaggtacc agatggaaaa 120 ccagaaaacc agtttgcttt taatggagaa ttcaaaaaca aggcttttgc tcttgaagtt 180 attaaatcca ctcatcaatg ttggaaagca ttgcttatga agaactgtaa tggaggagct 240 ataaattgca caaacgtgca gatatctgat agccctttcc gttgcactca agaggaagca 300 agatcattag ttgaatcggt atcatcttca ccaaataaag aaagtaatga agaagagcaa 360 gtgtggcact tccttggcaa gtgattgaaa catctgaaat tctgctgtca agattcccat 420 ctctaaggac tccaagactc tttttcccca agtgctagag acaagggggt ctatgagcat 480 ttac 484 <212> Type: DNA <211> Length: 484       SequenceName: # 661       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cggtccccag tgcagttggg tgaactaccg ttgcacactg gagtttctgg tgtctttgct 60 tggaactgac ctagctcgtg gcagggggaa ctcggctagc ggccccacag cccctgctga 120 ctcaaaacaa ctaatgaact ctggaagccc agccagggac aatgcacctt cacagagatt 180 ctgcactaat ctgagtgaag gtctaaggtt tggaatctcc ccctcatgga gagaagcttt 240 gtatggctgt catgcttaga cagtgattcc tgcaacttga ccttcaggct gggagaggtg 300 gagagccatg cctgttctcc ttccttgcta tggaatttgc tgacacaata tcttccgcct 360 ggtgctgggc atatcctaag aacttacaac tttcctgtat tatcctgtgt gagcagctgt 420 caccttattg ggggaa 436 <212> Type: DNA <211> Length: 436       SequenceName: # 662       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: caaacggaac ttgccgcgtc gaggactgtc gggctacagc atgctggcca tagggattgg 60 aaccctgatc tacgggcact ggagcataat gaagtggaac cgtgagcgca ggcgcctaca 120 aatcgaggac ttcgaggctc gcatcgcgct gttgccactg ttacaggcag aaaccgaccg 180 gaggaccttg cagatgcttc gggagaacct ggaggaggag gccatcatca tgaaggacgt 240 gcccgactgg aaggtggggg agtctgtgtt ccacacaacc cgctgggtgc cccccttgat 300 cggggagctg tacgggctgc gcaccacaga ggaggctctc catgccagcc acggcttcat 360 gtggtacacg taggccctgt g 381 <212> Type: DNA <211> Length: 381       SequenceName: # 663       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tccatcccgc acttacaaca gagtgccttt acacaaacct acggattggc agaaaaagat 60 cctcatatgg tcaggtcgct tcaaaaagga agatgaaatc ccagagactg tctcgttgga 120 gatgcttgat gctgcaaaga acaagatgcg agtgaagatc agctatctaa tgattgccct 180 gacggtggta ggatgcatct tcatggttat tgagggcaag aaggctgccc aaagacacga 240 gactttaaca agcttgaact tagaaaagaa agctcgtctg aaagaggaac agctatgaag 300 gccaaaacag agtagcagag gtatccgtgt tggctggatt ttgaaaatcc aggaattatg 360 ttataacgtg cctgtattaa aaaggatgtg gtatgaggat ccatttcata aagtatgatt 420 tgcccaaacc tgtaccattt ccgtatttct gctgtagaag tagaaataaa ttttcttaaa 480 taatgactgt gttttattgt tttgatccaa gtcaagtgta gcctctcagc cttttggaga 540 aa 542 <212> Type: DNA <211> Length: 542       SequenceName: # 664       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agtgcagggg ggctgcatgc gttgcctcct gagatcgagg ctgcaggata tgctcagact 60 ctagaggcgt ggaccaaggg gcatggagct tcactccttg ctggccaggg agttggggac 120 tcagagggac cacttggggc cagccagact ggcctcaatg gcggactcag tcacattgac 180 tgacggggac cagggcttgt gtgggtcgag agcgccctca tggtgctggt gctgttgtgt 240 gtaggtcccc tggggacaca agcaggcgcc aatggtatc 279 <212> Type: DNA <211> Length: 279       SequenceName: # 665       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gtcaccgcaa tttcatccag gacgaagtgc tgcgtttgat tcatgagtgt cctcatcagg 60 aagggaagag catccatgag ctccgggctc agctctgcga ccttagcgtc aaggccatca 120 aggaagcgat tgattatctg accgttgagg gccacatcta tcccactgtg gatcgggagc 180 attttaagtc tgctgattga ggcagggaaa acatcctttc atttttcgaa gacccttgca 240 tccagctgtg agtaattttg acctgttgac tttttaggag taggactaaa aaaaaaaatc 300 tcaagtggca ttctttgtca actcgctgct tttctaactg ctttgaactt ttcggatttt 360 ctgtatttga agctcagaga gagacggtga tggataaatt gacaactctg taggatttac 420 tagcaagcta atggaaacat gattttcggg gaagaaaaac tacagaaaat gtagaaattt 480 attatttaat tgtgttggag cttctttttc 510 <212> Type: DNA <211> Length: 510       SequenceName: # 666       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgtgcacggc tgtggcagct gttgatgcca gtgtcctcta actcatgctg tccttgtgat 60 taaacacctc tatctccctt gggaataagc acatacaggc ttaagctcta agatagatag 120 gtgtttgtcc ttttaccatc gagctacttc ccataataac cactttgcat ccaacactct 180 tcacccacct cccatacgca aggggatgtg gatacttggc ccaaagtaac tggtggtagg 240 aatcttagaa acaagaccac ttatactgtc tgtctgaggc agaagataac agcagcatct 300 cgaccagcct ctgccttaaa ggaaatcttt attaatcacg tatggttcac agataattct 360 ttttttaaaa aaacccaacc tcctagagaa gcacaactgt caagagtctt gtacacacaa 420 cttcagcttt gcatcacgag tcttgt 446 <212> Type: DNA <211> Length: 446       SequenceName: # 667       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcagatgtac aactcaccat accaccgggt gacagactgt gtacgggcag tgtggcaaaa 60 tgaaggggcc ggggcctttt accgcagcta caccacccag ctgaccatga acgttccttt 120 ccaagccatt cacttcatga cctatgaatt cctgcaggag cactttaacc cccagagacg 180 gtacaaccca agctcccacg tcctctctgg agcttgcgca ggagctgtag ctgccgcagc 240 cacaacccca ctggacgttt gcaaaacact gctcaacacc caggagtcct tggctttgaa 300 ctcacacatt acaggacata tcacaggcat ggctagtgcc ttcaggacgg tatatcaagt 360 aggtggggtg accgcctatt tccgaggggt gcaggccaga gtaatttacc agatcccctc 420 cacagccatc gcatggtctg tgtatgag 448 <212> Type: DNA <211> Length: 448       SequenceName: # 668       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cctcagcagc gcgaggtgct gcggcgctgc gtagaagtat caatcagccg gttgcttttg 60 tgagaagaat tccttggact gcggcgtcga gtcagctgaa agaacacttt gcacagttcg 120 gccatgtcag aaggtgcatt ttaccttttg acaaggagac tggctttcac agaggtttgg 180 gttgggttca gttttcttca gaagaaggac ttcggaatgc actacaacag 230 <212> Type: DNA <211> Length: 230       SequenceName: # 669       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: taaaaactga aattccctgt tctagttcct aacaattctc attacatact atgccagatt 60 acaaaatact tatttttaaa atgaaatcta tatattgact ttcttatcaa tcatcttact 120 gtgcaatcaa aattagagta ctttggtttg aaaacaacac ttagagcctc cagataactt 180 ttaagactta tttagctttg tgggtggtat tttcatgcaa ataagtaagg gtgggtttta 240 tattttgtag aagttttcgg tcctatttta atgctctttg tatggcagta tgtatatatt 300 gtgttaagtt cctcaagaat ctcct 325 <212> Type: DNA <211> Length: 325       SequenceName: # 670       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggaattctcc attaactgtg gattttacta aatagaatta ctggtgaagc agatttatcc 60 atcgagacta tctggtatgc gttatgtatg tagtctgttg ctgctgaaag atgtctgtgt 120 gcccgtatca acatgtgact tcatgtaaag tttctttgtg ttcacagttc ttagcaaatg 180 cagttacaat ccatagatag ccagcagtgg atgttactcc 220 <212> Type: DNA <211> Length: 220       SequenceName: # 671       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gcctgggcct agactgtggt gaggtcacta gattctactg ctcttccccc acattaatac 60 cttttccttc ctcagagaga aatctcccct aacctgaatt gcagccccct ccagtttgct 120 ttcctttggc cttccagacc ccaggaagtt ggccttccct tcctagtgct atggtttctg 180 ccattggcca tgatttcagg gagctggctg aggccggctg aggccacacc tgtgccagtg 240 gggcttccct ggtgctgcag cacttgtaaa ccacacacac agcctctctc cctggacata 300 cgttagcaca ttggcattca gtattggtgg cctggcatgg taggtactac ccaatgaaga 360 gtgtactata tattttcatt actataggcc atacttatac agacgtgt 408 <212> Type: DNA <211> Length: 408       SequenceName: # 672       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gacggcgtca aggtcgtggg acgtgacacg accgctgcgg cgtcagctca gccttgcaag 60 accccaggcg cccgcgctgc acctgcgact gtcgccgccg ccgtcgcagt cggaccaact 120 gctggcagaa tcttcgtccg cacggcccca gctggagttg cacttgcggc cgcaagccgc 180 cagggggcgc cgcagagcgc gtgcgcgcaa cggggaccac tgtccgctcg ggcccgggcg 240 ttgctgccgt ctgcacacgg tccgcgcgtc gctggaagac ctgggctggg ccgattgggt 300 gctgtcgcca cgggaggtgc aagtgaccat gtgcatcggc gcgtgcccga gccagttccg 360 ggcggcaaac atgcacgcgc agatcaagac gagcctgcac cgcctgaagc ccgacacggt 420 gccagcgccc tgctgcgtgc ccgccagcta caatcccatg gtgctcattc aaaagaccga 480 caccggggtg tcgctccaga cctatgatga cttgttagcc aaagactgcc actgca 536 <212> Type: DNA <211> Length: 536       SequenceName: # 673       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcaaaagtaa gttctccatc ccataaagcc atttaaattc attagaaaaa tgtccttacc 60 tcttaaaatg tgaattcatc tgttaagcta ggggtgacac acgtcattgt acccttttta 120 aattgttggt gtgggaagat gctaaagaat gcaaaactga tccatatctg ggatgtaaaa 180 aggttgtgga aaatagaatg tccagacccg tctacaaaag gtttttagag ttgaaatatg 240 aaatgtgatg tgggtatgga aattgactgt tacttccttt acagatctac agacagt 297 <212> Type: DNA <211> Length: 297       SequenceName: # 674       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagacagtgc ggtggacttc agtgaagttc cttatgactt cccctgaaat tgcttcctta 60 tcatgggggc aaatgaaagt aaaaggctct aatacaacct ataaggactg caaagtatgg 120 ccagggggta gtcggacttg ggattggaga gaaacaggaa ctgagcattc tcctggtgtg 180 cagcctgcag atgtgaagga agttgttgag aagggtgtac agactcttgt gattggccga 240 gggatgagtg aggccttgaa ggtgccttca tcaactgtgg agtacctcaa gaaacatggc 300 attgatgtgc gggtcctcca gacagagcag gcagtgaagg agtataatgc cttggttgcc 360 caaggggtca gggtgggagg tgtcttccat tccacctgct gatggagcct taagaggaga 420 ataaatcact aagtgcc 437 <212> Type: DNA <211> Length: 437       SequenceName: # 675       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctttcactct actcagttcc tgagggtcaa tcgaagtatg tggaggaggc aaggagccag 60 cttgaagaaa gcatctcaca gctccgacac tattgcgagc catacacaac ctggtgtcag 120 acagctatga ctatctccaa aatgcacctc ctggattttt ttccgagact tggtgttatt 180 ggttttgctg gccttattgg actccttttg gctagaggtt caaaaataaa gaagctagtg 240 tatccgcctg gtttcatggg attagctgcc tccctctatt atccacaaca agccatcgtg 300 tttgcccagg tcagtgggga gagattatat gactggggtt tacgaggata tatagtcata 360 gaagatttgt ggaaggagaa ctttcaaaag ccaggaaatg tgaagaattc acctggaact 420 aagtagaaaa cttcatgctc tgccatctta atcaggaaaa actagaccag acctctgtta 480 tcttctgtga aatcatccta caagcaaact aacctggaat cccttcac 528 <212> Type: DNA <211> Length: 528       SequenceName: # 676       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaatccccag tggaaccgga agagctggac tgatgagaaa catcagaaga acacatacta 60 ccttgttttc ctaatgccag aagggtgacc agtgaagatt caccgtcaaa ccatgaaagt 120 cctttcttgg atccacttta tcttgattag tctgcatttt actagttcac tggatccctc 180 ctctaggggc ctggggactt tcactgatgc tcttcctgat tctagagcaa aggtgtggga 240 aggggaaatg gaggaatgcc ctcctgtctg tgtcgttctc tgtgccacag ctacagatgc 300 agaaggtttc tctggatagc acacctctga atgtaaatca tgataaaatg gatatttgga 360 aacttactcc taagctgtga tttagggtgt atttctactt ctggactgcc tcaatatca 419 <212> Type: DNA <211> Length: 419       SequenceName: # 677       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ggcgtttgga ctccagtact caagacaggc tcatagcgct gaaannagta acaaattttg 60 gcgttccagt tgaagttttt gactctgaag aagctgaaat attccagaag aaacttgatg 120 agaccaccag attgctcagg gaactccagg aagcccagaa tgaacgtttg agcaccagac 180 cccctccgaa catgatctgt ctcttgggtc cctcatacag agaaatgcat cttgctgaac 240 aagtgaccaa taatcttaaa gaacttgcac agcaagtaac tccaggtgat atcgtaagca 300 cgtatggagt tcgaaaagca atggggattt ccattccttc ccccgtcatg gaaaacaact 360 ttgtggattt gacagaagac actgaagaac ctaaaaagac ggatgttgct gagtgtggac 420 ct 422 <212> Type: DNA <211> Length: 422       SequenceName: # 678       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgtccggccg cgaaggtggc aagaagaagc cactgaaaca gcccaagaag caggccaagg 60 agatggacga ggaagataag gctttcaagc agaaacaaaa agaggagcag aagaaactcg 120 aggagctaaa agcgaaggcc gcggggaagg ggcccttggc cacaggtgga attaagaaat 180 ctggcaaaaa gtaagctgtt ccttgtgcct gaggagatgg tgacccttta tttcatctgt 240 atttaaacct ctctattccc tgccataaca tcttttgcca cgtatagctg gaattaagtg 300 ttgtcttgga gctgtt 316 <212> Type: DNA <211> Length: 316       SequenceName: # 679       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcattccttt gctgctgcag ttgacaagcc ggctacaggg agtcggcgcg ctcggccagg 60 cagcctctga caatagcggc ccagaagatg caaagagaca agccaagaaa cagaagacaa 120 ggcggacgtg aggaggaagg ggacagttgc agtctcactt gggacaggcc acagccaggg 180 gtccggccac tacccgcccg tgggataaaa gccaaaagca tgcgtcagct aacttcagcc 240 tgtgctgctg ggcccgcacc ccatgtccct tgtcactgtg gcatcctgca cccatcctca 300 cccctccgta gagcccctcg tgcaatgcaa tgaatggacc ctcctgtcac tctgctgaac 360 agaattta 368 <212> Type: DNA <211> Length: 368       SequenceName: # 680       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acattgctca ccaacacaca gggtagaaaa ccactagctc ttcctggaga gaacagaaca 60 tgcagcctcc accacgtccc cagaaacagc cgcagacttg agctcactac atcaagaaca 120 ccacaccgcg ctccaaggaa cagctacaag cacagagaca gaggcataca gagacaaaga 180 gagaaagaga cgcaacatgg cagcagacac tgcttttttt attaaacatt aaaaaaaagg 240 tcaaaatcca agcaaacttg aacccgagaa tgtacacaga agtaggaaac acagagaaca 300 gagctgtccc agccagccag cgagcgatgc tcttttcgga gaacgtttca tagacggaag 360 tagattccat gggcctccaa gacaatagga tcctctctcc attcctcgcc atatgggttt 420 tgttttttaa gtcatttggt ttggggaggg ccttgttttt tttctgtttt gatattttta 480 ttttttctgc agtcaccggc tgccaacata atctgcacc 519 <212> Type: DNA <211> Length: 519       SequenceName: # 681       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agcagagagg gagccgttca tgtcagagac tcactgccag aaaagcctta cccatttggt 60 tttcactatt gagaccgcaa ctgcttgcac tgatcatttg gttcgtgagc agttggtgat 120 tttagttggt ctggtgttcg ggctaagaat attttattgt ggacttaatt acaaccactg 180 cactgtaatg attcaatgct gtattatgat attgctgtaa acaaaattca ttcttatatt 240 gtcacttatt ctttgcctga ttcagaagtt aaataggagc tttggaatca ttattcatga 300 cccctctgca aatgtgtcag tctccaaaga gagtatctcc ccccaaattt tgtgtagctt 360 cttttgttat ggaaaatggt ggacaaaaaa agaaactgtg ataactgggg cgttgttttt 420 taaaataaac tccagcacag ggatgctgtg catgcctgag ttgattccga a 471 <212> Type: DNA <211> Length: 471       SequenceName: # 682       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: agtgaatcac tgtagcaatg gctttgattc agaccttaaa atcacataag aagaattaca 60 acatgttatg gnatttttaa gtggcaggta ttgtaactgt tttttgtgtg caaaatactg 120 agtaaccact gggaaaatat ttcagatgaa agggatgaca aaagcatgtt gcgctttgca 180 tcagcaaggc attgacttct gaaaaaatga tctgaaaaaa nngtttcacc gtttgtcttc 240 ttacctcatt ttaagaagca tgtgaaaatg ggatactata gactactgag aatttcagaa 300 attgagaaca atttcataat aaaacggcta tatttgaaga gagaatacat tttatataaa 360 caggaaaata catttgacac tttatggaat tttatgagac tttttgtggg aacagaaggt 420 cttcaaattg taaaatgtaa agattgctct ttttattaag tctttaacag ggatgtattt 480 cattgtatgt tttgggtatg gctttggaa 509 <212> Type: DNA <211> Length: 509       SequenceName: # 683       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctgatgaagt tatgtctccc catggagaac ctatcaagat gcgaatggac tgcactctgg 60 atcagttttg ctggcgtcgt tggagttaaa atgccccgtt actgtcnttt tggaaacaat 120 gtcactctgg ctaacaaatt tgagtcctgc agtgtaccac gaaaaatcna tgtcagccca 180 acaacttaca gattactcaa agactgtcct ggtttcgtgt ttacccctcg atcaagggag 240 gaacttccac caaacttccc tagtgaaatc cccggaatct gccattttct ggatgcttac 300 caacaaggaa caaactcaaa accatgcttc caaaagaaag atgtggaaga tggcaatgcc 360 aattttttag gcaaagcatc aggaatagat tagcaaccta tatacctatt tataagtctt 420 tggggtttga ctcattgaag atgtgtagag cctctgaaag cactttaggg attgtagatg 480 gctaacaagc agtattaaaa tttcaggagc caagtcacaa tctttctcct gtttaaca 538 <212> Type: DNA <211> Length: 538       SequenceName: # 684       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tattcagcca aaattaccgt tttagaccag aatgaataga ctacactgat aaaatgtact 60 ggataatgcc acatcctata tggtgttata gaaatagtgc aaggaaagta catttgtttg 120 cctgtctttt cattttgtac attcttccca ttctgtattc ttgtacaaaa gatctcattg 180 aaaatttaaa gtcatcataa tttgttgcca taaatatgta agtgtcaata ccaaaatgtc 240 tgagtaactt cttaaatccc tgttctagca aactaatatt ggttcatgtg cttgtgtata 300 tgtaaatctt aaattatgtg aactattaaa tagaccctac tgtactgtgc tttggacatt 360 tgaattaatg taaatatatg taatctgtga cttgatattt tgttttattt ggctatttaa 420 aancataaat ctaaaatgtc ttatgttatc agattatgct attttgtata aagcacnnnn 480 nnnnncaann nnnnnncnaa annanaaant cactggaccg acgttttaac aacg 534 <212> Type: DNA <211> Length: 534       SequenceName: # 685       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaggaaatcc ctcatggcat tatcattccc taaggacaat gagatgtccc tccgctcaaa 60 tcctaaagcc ccctgatgaa agatttggct ctgatttgct gccaacttat tgg 113 <212> Type: DNA <211> Length: 113       SequenceName: # 686       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cagaaggagc tctgcctgta tgtcccagtc aaccacatgg atggtcgttg tgaaagtttt 60 aacttcctgc agagttaccg agtgctcagc gattgagctt tgaccacacc cgtgtttgtt 120 cctagtctgt tcccagccat aagcatctcc acaagccctc tgtggcttgt gtggcctgat 180 gtccatggcc accaagggcc tctcaccata cgcttctcca ctcaaccttt ggagagacac 240 ggaccaccaa aggcttgatt tttcttcatc ctacattata ttcaaaacaa acaggctggg 300 tgccgtagct ca 312 <212> Type: DNA <211> Length: 312       SequenceName: # 687       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gagtgtcagg aagatacttt ggggattgta aagaggaaga actgttgccc aaagctatgg 60 atgaatctgt tgcaagaaaa ctctgggata tcagtgaagt gatggttggc ctgctaaaat 120 aggaacaagg agtaaaagag ctgtttataa aactgcatat cagttatatc tgtgatcagg 180 aatggtgtgg attgagaact tgttacttga agaaaaagaa ttttgatatt ggaatagcct 240 gctaagaggt acatgtgggt attttggagt tactgaaaaa ttatttttgg gataagagaa 300 tttcagcaaa gatgttttaa atatatatag taagtataat gaataataag tacaatgaaa 360 aatacaatta tattgtaaaa ttataactgg gcaagcatgg atgacatatt aatatttgtc 420 agaattaagt gactcaaagt gctatcgaga ggtttttcaa gtatctttga gtttcatggc 480 caaagtgtta actagtttta ctacaatgtt tggtgtttgt gtggaaatta tctgcctggt 540 gtgtgcacac aagtctta 558 <212> Type: DNA <211> Length: 558       SequenceName: # 688       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tttagtggtg acggggtttg ctctgttggc caggctggtc tcaaactcct gacctcaggt 60 gatccccact tcagcctccc aaagtgctgg gatgacaggc atgagcctct gcacctggcc 120 tcgtgntttt ttttttagtt agccatttta tacgtgttta ctgaacacct gtcctgtgcc 180 catattctaa gtgccttacc tgcattaaac tcatgtaacc ttcacaaccc gaaaannnaa 240 aattatttag gatcaattaa ctggttaaaa aaaacttggg ggggggcccg gcacccaata 300 ccccttatag tgagtttatt acgggcccta ctggccgttg 340 <212> Type: DNA <211> Length: 340       SequenceName: # 689       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gttcatccgg cctgagggag agatcaccga ttacagaacc ngggtcagcg gggtcacccc 60 tcagcacatg gtgggggcca caccntttng ccgtgnccag gctagagatc ctgcagctcc 120 tgaaaggcaa gctggtggtg ggtcatgacc tgaagcacga cttnnnnnnn nnnnnnnnnn 180 acatgagcgg ctacacaatc tacgacacgt ccactnnnnn nnnnnnnnnn ngtgaggcca 240 agctggacca ctgcaggcgt gtctccctgc gggtgctgag tgagcgcctc ctgcacaaga 300 gcatccagaa cagcctgctt ggacacagcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360 nctatcaaat ctcccagaga atccgagccc gccgagggct gccccgcctg gctgtgtcag 420 actgaagccc catccagccc gttccgcagg gactagaggc tttcggcttt ttgggacagc 480 aactaccttg cttttgga 498 <212> Type: DNA <211> Length: 498       SequenceName: # 690       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: acggacctgc gagtcacaca actggtgacc cacaccagcg gctggagcag gaccctcttg 60 gggagaagag catcctgccc gcagccaggg cccctcatca aagtcctcgg tgttttttaa 120 attatcagaa ctgcccagga ccacgtttcc caggccctgc ccagctggga ctcctcggtc 180 cttgcctcct agtttctcag gcctggccct ctcaaggccc aggcacccca ggccggttgg 240 aggccccgac ttccactctg gagaaccgtc caccctggaa agaagagctc agattcctct 300 tggctctcgg agccgcaggg agtgtgtctt cccgcgccac cctccacccc ccgnnnnnnn 360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngccaggggc caaggagcta 420 ttttggggtc tcgtttgccc a 441 <212> Type: DNA <211> Length: 441       SequenceName: # 691       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gaagaagggg ccatcacagg atgccacccc tgncntgggt tgggnnnnnn nnnncacgac 60 cagccccttc ctgggtattt attctctatt tattggggat aggagaagag gcatcctgcc 120 tgggtgggac agccccttca gccccttctc ccctccccgc ctggccangg cagggccacc 180 ccactctacc tccttagctt tcnnnnnnnn nnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnaga gctgacggga ggccccagct ctgaggggag ggggtccgtg 300 gtanangcct ggggccggta gaggctcccc agggctccct tatgtccnnn nnnnnnnnnn 360 nngggtgtgg atgtaattag ctctgggggg cagttgggta gatgggtggg ggctcctggt 420 ggccttntgc tgcccaggcc acagccgcct ttgggttcca tcttgctaat aaacactggc 480 tctgggacta gaaa 494 <212> Type: DNA <211> Length: 494       SequenceName: # 692       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccactgcttt acaggacagg gggttgaagc tgagccccgc ctcacaccca cccccatgca 60 ctcaaagatt ggattttaca gctacttgca attcaaaatt cagaagaata aaaaatggga 120 acatacagaa ctctaaaaga tagacatcag aaattgttaa gttaagcttt ttcaaaaaat 180 cagcaattcc ccagcgtagt caagggtgga cactgcacgc tctggcatga tgggatggcg 240 accgggcaag ctttcttcct cgagatgctc tgctgcttga gagctattgc tttgttaaga 300 tataaaaagg ggtttctttt tgtctttctg taaggtggac ttccagcttt tgattgaaag 360 tcctagggtg attctatttc tgc 383 <212> Type: DNA <211> Length: 383       SequenceName: # 693       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ccagggatgc tctttgtaaa tatcggatgg gtgtgggagt gaggggttac ctccctcgcc 60 ccaaggttcc agaggcccta ggcgggatgg gctcgctgaa cctcgaggaa ctccaggacg 120 aggaggacat gggacttgcg tggacagtca gggttcactt gggctctctc tagctcccca 180 attctgcctg cctcctccct cccagctgca ctttaaccct agaaggtggg gacctggggg 240 gagggacagg gcaggcgggc ccatgaagaa agcccctcgt tgcccagcac tgtctgcgtc 300 tgctcttctg tgcccagggt gnctgccagc ccactgcctc ctgcctgggg tggcctggcc 360 ctcctggctg ttgcgacgcg ggcttctgga gcttgtcacc attggacagt ctccctgatg 420 gaccctcagt cttctcat 438 <212> Type: DNA <211> Length: 438       SequenceName: # 694       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: cttggccagt tttaccagga ggtgcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc 120 caggaggggc ccccgggagt ggagatttcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 nnnnnnctgt gcccaccctg tacacttggc ttncccctgc aactgcaggg ccgcttctgg 240 ggcctggacc accatgggga ggaagagtcc cactcattac aaataaanaa aggtggtgtg 300 ancctgngaa aaaaaannnn nnnnntccat gtggccaaat cctagggcct caacctcgca 360 tcctgaacct tagcatcgtg gaacacagaa gcttccactg tcagctctca agagnccatg 420 nccaggaagg cccatgctga gctttcagtc cagccccttc attttacaaa caagganact 480 gagctcgaac cacccatttg agatgtcact gtggccccca gntagaggcc nagggctggg 540 agcattctcc aggagcagag gttcagtctg cttcatggtc tct 583 <212> Type: DNA <211> Length: 583       SequenceName: # 695       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: gggatcacag accatttctt tctttcggcc aggctgaggc cctgacgtgg atgggcaaac 60 tgcaggcctg ggnaaggcag caagccgggc cgtccgtgtt ccatcctcca cgcacccccn 120 cctatcgttg gttcgnnnnn nnnnnnnnnn ncttgtgcat gacgccctgc tctggggagc 180 gtctggcgcg atctctgcct gcttactcgg gaaatttgct tttgccaaac ccgctttttc 240 g 241 <212> Type: DNA <211> Length: 241       SequenceName: # 696       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: atctactgtg cacatccagg cctgtngnca cagtcccctg ctaaagttgc tcaggtgttc 60 tagtcctgac ttcacctttt tgatttggtg tgtgccctag ggtatgtacc cttccccatc 120 tgagcctcgg tgtgtcnnnn nnnnnnnnnn nnnnnnnnng gactgtatga tttccaaggn 180 ctctaccagt cagtggttct gatgtcatcg ggtggaggtg gtgttctata cctaaaggat 240 gacctgctcc agaaacagca ccagcacagc atgtattttc ttctcttctg aaagttctgg 300 cttgtagacc cctcccntcc tttgcaaagg tatgggatag aggggtcaga tgcagatctc 360 tactgtaaaa tgggctccct ggtatctcct gtcttcccta ctgctccaaa ccctaaattt 420 tggttg 426 <212> Type: DNA <211> Length: 426       SequenceName: # 697       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgatgcttcc tgctcacctg ggccaccctc tctccaggac ttgtcagctg gtggttcagc 60 cccttctcca accccttcat aagcttgggc cactgcctgg gacccagcag acactgccca 120 ggactcttta gtgcactcac tcttgtctgc cccctacctt ccctcctngg aaccacacta 180 cttgnaatca ccattacttt gcctcgctgg cagagttggg tcnaagtgnc cctctccttg 240 accttgagat gaaggtcaag agcacaggga ccaggccttg gttaggctga gctcccagca 300 ggacaccgcc tgcagaaagg acctgccctg ataatgtccc ttccccagat tctcaagcag 360 atgcccaagg gaggtcccca cagagccaga gtgcctgagg cttcctgctt gagaacctgc 420 cccctggatc ttggacactt acagattgag cnnnnnnnnn nnnnnnggtc tcactccaga 480 gggtcagaac gtttgcttta gttttttcat ctgttttgtt ccttgagtca g 531 <212> Type: DNA <211> Length: 531       SequenceName: # 698       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: aacatccagc cattcagaca aagggggcct ggagatacag agagcccann naatgcctgc 60 tggattgtct cctgatgagt acatgtggac tcacctgagg aagggaagga agggaataat 120 cttttatgtt tcatttacct tatgaaaagt gttaaaacat tgccaactca aaataacatt 180 atttaatgca tgtgcaaagt taggtcttcc cagttgtctc agtgctgagg aacctcatca 240 gagaagcatg gaagatgcca aaggattttt ggaaggtaaa gaaggctgaa tagtgaccac 300 atgggcctgt tttcagggtc ccagcttagt taagtcaccc atgcacctgg tcattgtgtc 360 tcccntgcac atccagcgtt tctcagaagc agacccaccc ttaagttgac aggattgatg 420 gaacatgctc tcctgctcaa ggcacaacct ctgggctgga gtagaggact ctggtgggaa 480 ggttttgctg ctaatgtatt tatggaatga atgtatttca ttcaaatctg tattcctcta 540 ggaaggatta aa 552 <212> Type: DNA <211> Length: 552       SequenceName: # 699       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: actgtggtga ggtcactaga ttctactgct cttcccccac attaatacct tttccttcct 60 cagagagaaa tcntccccta acctgaattg cagccccctc cagtttgctt tcctttggcc 120 ttccagaccc caggaagttn ggccttccct tcctagtgct atggtttctg ccattggcca 180 tgatttcagg gagctggctg aggccggctg aggnnccaca ncctgtgnnc cagtggggnn 240 cttccctggt gctgcagcac ttgtaaacca cacacacagc ctctctccct ggacatacgt 300 tagcacattg gcattcagta ttggtggcct ggcatggtag gtactaccca atgaagagtg 360 tactatatat tttcattact ataggccata cttatacaga cgtgtatata tatttatata 420 agatctacct atcttaggat ggaacct 447 <212> Type: DNA <211> Length: 447       SequenceName: # 700       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ttctctaagt taacagaaga ggaactattg gacagagaat ttgaccttct aagatcaagt 60 aagggacact tgaaggctta ttttgcttca cagtaaaata acagctctat tattattcag 120 caaggccaaa gacttttgag annnnnnnng naaantnntt ttnnnnnntt nnnnnnnnnn 180 nnnnnnncat cttcttatac atatactatc aaattatgtt gtgtgncatt agaaatcagt 240 tgcttgatag tagctattaa acccaatatt gctgatagta tgctaatatc ctaaaactta 300 aatattgcat atctatgaat gttaaattca gaatatctct aaaacatgga aaattgatgt 360 ttcaataaaa agggagacat tttattattt tgccttacta atgattttgc agctctgttt 420 ttctgcacac tcaatagaaa atattgtggg tctgagatgc cctttgaaaa tgcctgaaag 480 aaaacatggg ctactacatt atgttaatgt tttgtaatgt ccttttaatg agtggtgaca 540 taaaagggct gctttgttgt cctgatatgg caaa 574 <212> Type: DNA <211> Length: 574       SequenceName: # 701       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tcttgacaaa acctaacttg cgcagaaaac aagatgagat tggcatggct ttatttgttt 60 tttttgtttt gttttggttt tttttttttt tttggcttga ctcaggattt aaaaactgga 120 acggtgaagg tgacagcagt cggttggagc gagcatcccc caaagttcac aatgtggccg 180 aggactttga ttgcacattg ttgttttttt aatagtcatt ccaaatatga gatgcattgt 240 tacaggaagt cccttgccat cctaaaagcc accccacttc tctctaagga gaatggccca 300 gtcctctccc aagtccacac aggggaggtg atagcattgc tttcgtgtaa attatgtaat 360 gcaaaatttt tttaatcttc gccttaatac ttttttattt tgttttattt tgaatgatga 420 gccttcgtgc ccccccttcc ccctttttgt cccccaactt gagatgtatg aaggcttttg 480 gtctccctgg gagtgggtgg aggcagccag ggcttacctg tacactgact tgagacca 538 <212> Type: DNA <211> Length: 538       SequenceName: # 702       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: accacggccg agcgggaaat cgtgcgtgac attaaggaga agctgtgcta cgtcgccctg 60 gacttcgagc aagagatggc cacggctgct tccagctcct ccctggagaa gagctacgag 120 ctgcctgacg gccaggtcat caccattggc aatgagcggt tccgctgccc tgaggcactc 180 ttccagcctt ccttcctggg catggagtcc tgtggcatcc acgaaactac cttcaactcc 240 atcatgaagt gtgacgtgga catccgcaaa gacctgtacg ccaacacagt gctgtctggc 300 ggcaccacca tgtaccctgg cattgccgac aggatgcaga aggagatcac tgccctggca 360 cccagcacaa tgaagatcaa gatcattgct cctcctgagc gcaagtactc cgtgtggatc 420 ggcggctcca tcctggcctc gctgtccacc ttccagcaga tgtggatcag caagcaggag 480 tatgacgagt ccggcccctc catcgtccac cgcaaatgct tctaggcgg 529 <212> Type: DNA <211> Length: 529       SequenceName: # 703       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: ctggatatat caagactgag ttgatttctg tgtctgaagt tcacccttct agacttcaga 60 ccacagacaa cctgctcccc atgtctcctg aggagtttga cgaggtgtct cggatagtgg 120 gctctgtaga attcgacagt atgatgaaca cagtatagag catgaatttt tttcatcttc 180 tctggcgaca gttttccttc tcatctgtga ttccctcctg ctactctgtt ccttcacatc 240 ctgtgtttct agggaaatga aagaaaggcc agcaaattcg ctgcaacctg ttgatagcaa 300 gtgaattttt ctctaactca gaaacatcag ttactctgaa gggcatcatg catcttactg 360 aaggtaaaat tgaaaggcat tctctgaaga gtgggtttca caagtgaaaa acatccagat 420 acacccaaag tatcaggacg agaatgaggg tcctttggga aaggagaagt taagcaacat 480 ctagcaaatg ttatgcataa agtcagtgcc caactgttat aggttgttgg ataaatcagt 540 ggttatttag ggaactgctt gacgtaggaa cggtaaattt ctgtgggag 589 <212> Type: DNA <211> Length: 589       SequenceName: # 704       SequenceDescription: Sequence -------- <213> OrganismName: human <400> PreSequenceString: tgccaacctc ttacgtgcgc ctttctgccg gacgcgagca gatgaacgaa cagactcagg 60 cgatgtgctt tatggcaggc gcaaactcga ttttctacgg ttgcaaactg ctgaccacgc 120 cgaatccgga agaagataaa gacctgcaac tgttccgcaa actggggcta aatccgcagc 180 aaactgccgt gctggcaggg gataacgaac aacagcaacg tcttgaacag gcg 233 <212> Type: DNA <211> Length: 233       SequenceName: # 705       SequenceDescription:  

Claims (39)

a. Obtaining a biological sample from a patient with acute myeloid leukemia (AML); And b. Measuring a biomarker associated with a marker gene corresponding to a marker gene selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, wherein the cut-off ( A method for assessing AML status, wherein the expression level of a marker gene above or below cut-off levels is indicative of AML status. a. Obtaining a biological sample from a patient with acute myeloid leukemia (AML); And b. Measuring a biomarker associated with a marker gene corresponding to a marker gene selected from Table 3, Table 4, Table 5, Table 7, Table 8, or Table 9, wherein above or below the cut-off level already measured A method of staging an AML patient, wherein the expression level of the marker gene of is an indicator of AML survival. a. Obtaining a biological sample from a patient with acute myeloid leukemia (AML); And b. Measuring a biomarker associated with a marker gene corresponding to a marker gene selected from Table 3, Table 4, Table 5, Table 7, Table 8, or Table 9, wherein above or below the cut-off level already measured The level of expression of the marker gene of the method of determining the AML patient treatment protocol is a sufficient indicator of the response to the therapy that allows the clinician to determine the extent and type of the recommended therapy to provide the appropriate therapy. . a. Obtaining a biological sample from a patient with acute myeloid leukemia (AML); b. Measuring a biomarker associated with a marker gene corresponding to a marker gene selected from Table 3, Table 4, Table 5, Table 7, Table 8, or Table 9, wherein the marker gene above or below the cut-off level already measured Expression level is indicative of response to therapy); And c. If the patient has a responder profile, treating the patient with adjuvant therapy. a. Obtaining a biological sample from a patient with acute myeloid leukemia (AML); And b. Measuring a biomarker associated with the marker gene corresponding to the marker gene selected from Table 3, wherein the expression level of the marker gene above or below the measured cut-off level is determined by the clinician. A method of determining whether the risk of death of an AML patient is high or low, which is a sufficient indicator of mortality risk, which allows to determine the extent and type of the risk of death. 6. The method of claim 1, further comprising determining the expression level of one or more genes constitutively expressed in the sample. 7. The method of any one of claims 1-5, wherein the specificity is at least about 40%. 6. The method of claim 1, wherein the sensitivity is at least about 80%. 7. The method of claim 28, wherein the p-value is less than 0.05. The method of claim 1, wherein the gene expression is measured in a microarray or gene chip. The method of claim 10, wherein the microarray is a cDNA array or an oligonucleotide array. The method of claim 10, wherein the microarray or gene chip further comprises one or more internal control reagents. The method of claim 1, wherein the gene expression is measured by nucleic acid amplification performed by polymerase chain reaction (PCR) of RNA extracted from the sample. The method of claim 13, wherein the PCR is reverse transcription polymerase chain reaction (RT-PCR). The method of claim 14, wherein the RT-PCR further comprises one or more internal control reagents. The method of claim 1, wherein the gene expression is detected by measuring or detecting a protein encoded by the gene. The method of claim 16, wherein the protein is detected by an antibody specific for that protein. The method of claim 1, wherein the gene expression is detected by measuring the properties of the gene. The method of claim 18, wherein the property to be measured is selected from the group consisting of DNA amplification, methylation, mutations and allelic variations. Measuring the results of the method according to any one of claims 1 to 5; And A method for generating an acute myeloid leukemia (AML) prognostic patient report, comprising generating a report representing the results. The method of claim 20, wherein the report contains an assessment of patient outcomes and / or a risk probability for the patient population and / or a tendency or response to chemotherapy. A patient report generated by the method according to claim 21. To detect an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, their complements or portions thereof A kit for performing an assay for measuring acute myeloid leukemia (AML) prognosis in a biological sample comprising a substance. The kit of claim 23 further comprising a reagent for performing microarray analysis. The kit of claim 24, further comprising a medium in which the nucleic acid sequence, its complement, or a portion thereof is assayed. Detecting an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, their complements or portions thereof A product for assessing acute myeloid leukemia (AML) status, comprising a substance for treatment. 27. The article of claim 26 further comprising a reagent for performing microarray analysis. The article of claim 27, further comprising a medium in which the nucleic acid sequence, its complement, or a portion thereof is assayed. Microarray or gene chip for carrying out the method according to any one of claims 1 to 5. The isolated nucleic acid sequence of claim 29, wherein the combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8, or Table 9, complements thereof Or a microarray comprising a portion thereof. 33. The microarray of claim 30 wherein the measurement or characterization is at least 1.5-fold over- or under-expression. 32. The microarray of claim 30 wherein the measurement provides a statistically significant p-value overexpression or underexpression. 33. The microarray of claim 32 wherein the p-value is less than 0.05. 32. The microarray of claim 30 comprising a cDNA array or an oligonucleotide array. 31. The microarray of claim 30 further comprising one or more internal control reagents. Comprising an isolated nucleic acid sequence of a combination of genes selected from the group consisting of marker genes corresponding to marker genes selected from Table 3, Table 4, Table 5, Table 7, Table 8 or Table 9, complements thereof, or portions thereof Diagnostic / prognostic portfolio (protfolio). The portfolio of claim 36, wherein the measurement or characterization is at least 1.5-fold over or low expression. The portfolio of claim 37, wherein the measurement provides a statistically significant p-value overexpression or underexpression. The portfolio of claim 37, wherein the p-value is less than 0.05.

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