ABSTRACT
Medicinal plants have been used for centuries to ensure the well-being of populations. The chemical characterization of the medicinal plant revealed the presence of cardiac glycosides, tannins, flavonoids, alkaloids free and combined Anthraquinones, and cyanogenic glycosides from Uvaria chamae. Alkaloids such as armepavine, racem O,O-dimethylcoclaurine, nornan-tenine, nantenine, and corydine have been isolated. Uncommon o-hydroxybenzylated flavanones and chalcones: diuvaretin, isochamanetin chamanetin, isouvaretin, dichamanetin, and uvaretin have been isolated. U. chamae induced significant reductions in weight, plasma glucose levels, low density lipoprotein and cholesterol, in diabetic rats. In a study performed in Nigeria, the leaves ethanolic extracts of U. chamae had an interesting anti-ulcer activity on Wistar rats. This activity was superior to that of cimetidine. Induction of the ulcer was carried out using indomethacin, histamine, and stress models. U. chamae root bark ethanol extract showed a significant trypanocidal effect that can be compared with that of diminazene aceturate.
