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SGI-1776: sc-364615
SGI-1776 (CAS 1025065-69-3)
See product citations (1)
Alternate Names:
SGI-1776 free base
Application:
SGI-1776 is a potent apoptotic that targets Pim and FLT3 in AML and CLL cells
CAS Number:
1025065-69-3
Purity:
≥98%
Molecular Weight:
405.42
Molecular Formula:
C20H22F3N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SGI-1776 is a novel ATP-competitive inhibitor of Pim-1, Pim-2, and Pim-3 (IC50 = 7, 363, and 69 nM, respectively). In addition to inhibiting Pim, this compound also inhibits FLT3 (IC50 = 44 nM). SGI-1776 is also cytotoxic in AML primary cells, regardless of the FLT3 mutation status, which results in Mcl-1 protein decline. SGI-1776 inhibits tumor growth for intermediate EFS T/C activity in 1 of 39 evaluable models.