About
My training is as a biological generalist: I can PCR, measure KD, immunize a mouse and…
Activity
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Cool! Hopefully this will open the door to more of these kinds of drugs! https://lnkd.in/duq3Cz9j
Cool! Hopefully this will open the door to more of these kinds of drugs! https://lnkd.in/duq3Cz9j
Shared by Hugo Jhun, PhD
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Welcome Patrice Matchaba, MD as the new Chief Executive Officer of the Bill & Melinda Gates Medical Research Institute! Dr. Matchaba began his…
Welcome Patrice Matchaba, MD as the new Chief Executive Officer of the Bill & Melinda Gates Medical Research Institute! Dr. Matchaba began his…
Liked by Hugo Jhun, PhD
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The Johns Hopkins Bloomberg School of Public Health had the honor of being formally recognized by the American Society for Microbiology (ASM) as an…
The Johns Hopkins Bloomberg School of Public Health had the honor of being formally recognized by the American Society for Microbiology (ASM) as an…
Liked by Hugo Jhun, PhD
Experience
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Education
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Johns Hopkins Bloomberg School of Public Health
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Activities and Societies: Chemistry Honor Society
Thesis: "Synthesis of sensors for Nek2 activity, HTS of potential Nek2 inhibitors, and synthesis of a photolabile PTP1B inhibitor."
Kumar, S. (presenter), Dana, D., Das, T.K., Paroly, S.S., Perumal, S.K., Singh, S., Jhun, H., Pendse, J., Cagan, R., Talele, T.T. "Chemical Biology Approaches to Studying The Function of Nek2
Kinase in Cancer Metastasis" Poster presentation at the 2013 Gordon Research Conference: High Throughput Chemistry and Chemical Biology, New London, NH. -
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Thesis: "Disparate Housewives: Marriage in the 19th Century as seen through Pride and Prejudice and The Heavenly Twins"
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Thesis: "'What should we do today?:' An Investigation of High School Juniors' Attitudes on Pedagogy"
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Activities and Societies: Theater Guild
Director: The Compleat Works of Wllm Shkspr (abridged); The Chairs
Stage Manager: Demonwine, The Odd Couple
Publications
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Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein
Malaria Journal
See publicationStatistical analysis of the protection granted by two monoclonal antibodies agains the malaria parasite provide guidance regarding selection of the appropriate experimental design, dose selection, and group sizes.
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Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages
Malaria Journal
See publicationThe protective effect of vaccines or monoclonal antibodies targeting the human malaria parasite prior to blood stage infection can be measured using a mouse malaria parasite expressing the surface antigen of the human parasite that also expresses luciferase and GFP. This allows for much faster and more precise measurements of liver stage infection than previous assays.
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A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites
PLOS Pathogens
See publicationGenetically knocking in a metabolic bypass to essential biochemistry in the malaria parasite allows investigation of crucial biochemical pathways to reveal new drug targets.
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Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum
mBio
See publicationUsing a bacterially derived lipoamidase, we determined that attachment of a small molecule named lipoate is crucial for the mitochondrion of the malaria parasite, Plasmodium falciparum. These insights open the door to drug targeting novel pathways the parasite needs for this lipoate attachment.
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Host biotin is required for liver stage development in malaria parasites
Proceedings of the National Academies of Science
See publicationGene knockouts in both the human and mouse malaria models demonstrate that the malaria parasite needs the biotin cofactor during the liver stage of infection, but not during the other developmental stages.
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Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis
Nature Oncogenesis
Overexpression of dNek2 in Drosophila melanogaster and hNek2 in human cell lines results in downstream upregulation of various mitogenic genes. Inhibition of either PI3PK or direct inhibition of Nek2 abrogates these phenotypes.
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Honors & Awards
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VRD Bold Moves Team Award
Pfizer
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Better Together IP Award
Pfizer
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VRD Bold Moves Team Award (2 Team Awards)
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Recognizing Our Values Award
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Upjohn Award
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Delta Omega Scholarship
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Competitive annual scholarship for science in the pursuit of public health.
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Hopkins Sommer Scholarship
Johns Hopkins Bloomberg School of Public Health
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Frances Coventry Scholarship
Johns Hopkins Bloomberg School of Public Health
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Chemistry Honor Society
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Inducted to Beta Delta Chi, the Queens College Chemistry Department Honor Society.
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Departmental Service Award
Queens College Department of Chemistry and Biochemistry
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Stanley G. Konkol Memorial Award
Queens College Department of Chemistry and Biochemistry
Organizations
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American Association for the Advancement of Science
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American Society for Biochemistry and Molecular Biology
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More activity by Hugo
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Sharing our experience with Alphafold3 after determining the cryo-EM structure of Retron-Eco1 See Molecular Cell 👇…
Sharing our experience with Alphafold3 after determining the cryo-EM structure of Retron-Eco1 See Molecular Cell 👇…
Liked by Hugo Jhun, PhD
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Today we celebrate the rich heritage, diverse cultures, & incredible resilience of our people & beautiful continent. Let's embrace our collective…
Today we celebrate the rich heritage, diverse cultures, & incredible resilience of our people & beautiful continent. Let's embrace our collective…
Liked by Hugo Jhun, PhD
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A few comments on the recent changes we are seeing in the SARS-CoV-2 genes. This virus is here to stay and it seems to have multiple ways to avoid…
A few comments on the recent changes we are seeing in the SARS-CoV-2 genes. This virus is here to stay and it seems to have multiple ways to avoid…
Liked by Hugo Jhun, PhD
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𝐇𝐚𝐯𝐞 𝐲𝐨𝐮 𝐞𝐯𝐞𝐫 𝐰𝐚𝐧𝐭𝐞𝐝 𝐭𝐨 𝐜𝐨𝐦𝐦𝐚𝐧𝐝 𝐚 𝐦𝐚𝐜𝐫𝐨𝐩𝐡𝐚𝐠𝐞 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐩𝐚𝐭𝐡𝐨𝐠𝐞𝐧𝐬? 𝐖𝐞𝐥𝐥, 𝐧𝐨𝐰 𝐲𝐨𝐮 𝐜𝐚𝐧!…
𝐇𝐚𝐯𝐞 𝐲𝐨𝐮 𝐞𝐯𝐞𝐫 𝐰𝐚𝐧𝐭𝐞𝐝 𝐭𝐨 𝐜𝐨𝐦𝐦𝐚𝐧𝐝 𝐚 𝐦𝐚𝐜𝐫𝐨𝐩𝐡𝐚𝐠𝐞 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐩𝐚𝐭𝐡𝐨𝐠𝐞𝐧𝐬? 𝐖𝐞𝐥𝐥, 𝐧𝐨𝐰 𝐲𝐨𝐮 𝐜𝐚𝐧!…
Liked by Hugo Jhun, PhD
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Thank you Yonatan Chemla, PhD, John Marken, Niklaus Evitt, Hannah Boardman for a wonderful discussion!
Thank you Yonatan Chemla, PhD, John Marken, Niklaus Evitt, Hannah Boardman for a wonderful discussion!
Liked by Hugo Jhun, PhD
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📢 📢 It is exciting to announce that Touchlight and the National Physical Laboratory (NPL) have been awarded a grant from Innovate UK to develop…
📢 📢 It is exciting to announce that Touchlight and the National Physical Laboratory (NPL) have been awarded a grant from Innovate UK to develop…
Liked by Hugo Jhun, PhD
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I learned some things at a book release q&a last night about teen suicide prevention, at the 92Y — of course from a sociological perspective! A key…
I learned some things at a book release q&a last night about teen suicide prevention, at the 92Y — of course from a sociological perspective! A key…
Liked by Hugo Jhun, PhD
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