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GBP1 Recombinant Rabbit Monoclonal Antibody (3X7O9), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Supplier: Thermo Scientific MA542606
This item is not returnable.
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Description
Positive test controls include: HeLa, Jurkat, Rat heart. The target is usually found in the following locations: Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor, Secreted. Immunogen sequence: RVKAESAQAS AKMLQEMQRK NEQMMEQKER SYQEHLKQLT EKMENDRVQL LKEQERTLAL KLQEQEQLLK EGFQKESRIM KNEIQDLQTK MRRRKACTIS
GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
Specifications
| GBP1 | |
| Recombinant Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P32455 | |
| GBP1 | |
| A synthetic peptide corresponding to a sequence within amino acids 493-592 of human GBP1 (P32455). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Western Blot | |
| 3X7O9 | |
| Unconjugated | |
| GBP1 | |
| GBP1; Gbp-1; Gbp2b; GTP-binding protein 1; guanine nucleotide-binding protein 1; guanylate binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate binding protein 2b; guanylate nucleotide binding protein 1; guanylate-binding protein 1; huGBP-1; interferon-gamma-inducible protein MAG-1; interferon-induced guanylate-binding protein 1; Mag-1; Mpa1; Mpa-1 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 2633, 304266 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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