WO2004000833A1 - Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase - Google Patents
Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase Download PDFInfo
- Publication number
- WO2004000833A1 WO2004000833A1 PCT/US2003/019266 US0319266W WO2004000833A1 WO 2004000833 A1 WO2004000833 A1 WO 2004000833A1 US 0319266 W US0319266 W US 0319266W WO 2004000833 A1 WO2004000833 A1 WO 2004000833A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- independently selected
- optionally substituted
- formula
- ring
- Prior art date
Links
- 0 **c1nc(**)nc(*)c1* Chemical compound **c1nc(**)nc(*)c1* 0.000 description 3
- QSXPEQGKQJWCQT-UHFFFAOYSA-N CCC(Nc(cc1)ccc1Sc1nc(Nc2cc(C)n[nH]2)cc(N(CC2)CCC2N)n1)=O Chemical compound CCC(Nc(cc1)ccc1Sc1nc(Nc2cc(C)n[nH]2)cc(N(CC2)CCC2N)n1)=O QSXPEQGKQJWCQT-UHFFFAOYSA-N 0.000 description 1
- XIXPFJKLQHYUHU-UHFFFAOYSA-N CCC(Nc(cc1)ccc1Sc1nc(Nc2ccn[nH]2)cc(N(C)c2ccccc2)n1)=O Chemical compound CCC(Nc(cc1)ccc1Sc1nc(Nc2ccn[nH]2)cc(N(C)c2ccccc2)n1)=O XIXPFJKLQHYUHU-UHFFFAOYSA-N 0.000 description 1
- MJYRIFGGIFKCOC-HEHNFIMWSA-N CCC/C(/Nc1nc(Sc(cc2)ccc2NC(CC)=O)nc(N2CCN(C)CC2)c1)=C\C(C)=C Chemical compound CCC/C(/Nc1nc(Sc(cc2)ccc2NC(CC)=O)nc(N2CCN(C)CC2)c1)=C\C(C)=C MJYRIFGGIFKCOC-HEHNFIMWSA-N 0.000 description 1
- NHFBXYAJAQAXTN-UHFFFAOYSA-N CCCN(CC1)CCN1c1nc(Sc(cc2)ccc2NC(C2CC2)=O)nc(Nc2ccn[nH]2)c1 Chemical compound CCCN(CC1)CCN1c1nc(Sc(cc2)ccc2NC(C2CC2)=O)nc(Nc2ccn[nH]2)c1 NHFBXYAJAQAXTN-UHFFFAOYSA-N 0.000 description 1
- HJYPMGSPRCTRSA-UHFFFAOYSA-N CCN(CC)c1cc(Nc2ccn[nH]2)nc(Sc(cc2)ccc2NC(C2CC2)=O)n1 Chemical compound CCN(CC)c1cc(Nc2ccn[nH]2)nc(Sc(cc2)ccc2NC(C2CC2)=O)n1 HJYPMGSPRCTRSA-UHFFFAOYSA-N 0.000 description 1
- DEGLWTBIDRWYGG-UHFFFAOYSA-N CCN(CC1)CCN1c1nc(Sc(cc2)ccc2NC(C2CC2)=O)nc(Nc2ccn[nH]2)c1 Chemical compound CCN(CC1)CCN1c1nc(Sc(cc2)ccc2NC(C2CC2)=O)nc(Nc2ccn[nH]2)c1 DEGLWTBIDRWYGG-UHFFFAOYSA-N 0.000 description 1
- RJLQAXDONYXUFM-UHFFFAOYSA-N CN1C(Sc(cc2)ccc2NC(C2CC2)=O)=NC(NCCN2CCCC2)=CC1Nc1ccn[nH]1 Chemical compound CN1C(Sc(cc2)ccc2NC(C2CC2)=O)=NC(NCCN2CCCC2)=CC1Nc1ccn[nH]1 RJLQAXDONYXUFM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
Description
Claims
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA05000068A MXPA05000068A (en) | 2002-06-20 | 2003-06-19 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase. |
NZ537720A NZ537720A (en) | 2002-06-20 | 2003-06-19 | Substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinases and processes for their preparation |
UAA200500520A UA81420C2 (en) | 2002-06-20 | 2003-06-19 | Process for the preparation of substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase |
KR1020047020794A KR101067254B1 (en) | 2002-06-20 | 2003-06-19 | Pyrimidine derivatives as inhibitors of protein kinase and compositions comprising the same |
EP03739195A EP1517905B1 (en) | 2002-06-20 | 2003-06-19 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinases |
AT03739195T ATE556068T1 (en) | 2002-06-20 | 2003-06-19 | METHOD FOR PRODUCING SUBSTITUTED PYRIMIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES |
KR1020107028539A KR101141959B1 (en) | 2002-06-20 | 2003-06-19 | Pyrimidine derivatives as inhibitors of protein kinase and compositions comprising the same |
CA2489824A CA2489824C (en) | 2002-06-20 | 2003-06-19 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinases |
BR0312443-6A BR0312443A (en) | 2002-06-20 | 2003-06-19 | Process for preparing substituted pyrimidines and pyrimidine derivatives as protein kinase inhibitors |
JP2004515904A JP4237701B2 (en) | 2002-06-20 | 2003-06-19 | Process for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinases |
EA200500053A EA012869B1 (en) | 2002-06-20 | 2003-06-19 | Substituted pyrimidines, compositions based thereon and use substituted pyrimidines as inhibitors of protein kinases |
AU2003245568A AU2003245568B2 (en) | 2002-06-20 | 2003-06-19 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase |
ES03739195T ES2386781T3 (en) | 2002-06-20 | 2003-06-19 | Procedure for preparing substituted pyrimidines and pyrimidine derivatives as protein kinase inhibitors |
IL16584904A IL165849A0 (en) | 2002-06-20 | 2004-12-19 | Process for preparing pyrimidine derivatives novelpyrimidine derivatives and pharmaceutical composi tions containing the same |
IS7606A IS7606A (en) | 2002-06-20 | 2004-12-20 | Process for making pyrimidine and pyrimidine derivatives which inhibit protein kinase |
NO20050144A NO331925B1 (en) | 2002-06-20 | 2005-01-11 | Substituted pyrimidines as protein kinase inhibitors |
HR20050064A HRP20050064A2 (en) | 2002-06-20 | 2005-01-20 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase |
HK05108425.3A HK1077057A1 (en) | 2002-06-20 | 2005-09-23 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinases |
HK06100957.5A HK1081178A1 (en) | 2002-06-20 | 2006-01-20 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase |
US12/436,407 US8268829B2 (en) | 2002-06-20 | 2009-05-06 | Substituted pyrimidines useful as protein kinase inhibitors |
NO20110523A NO20110523L (en) | 2002-06-20 | 2011-04-05 | Process for preparing substituted pyrimidines |
US13/585,861 US8779127B2 (en) | 2002-06-20 | 2012-08-15 | Processes for preparing substituted pyrimidines |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39065802P | 2002-06-20 | 2002-06-20 | |
US60/390,658 | 2002-06-20 | ||
US41160902P | 2002-09-18 | 2002-09-18 | |
US60/411,609 | 2002-09-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004000833A1 true WO2004000833A1 (en) | 2003-12-31 |
Family
ID=30003168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/019266 WO2004000833A1 (en) | 2002-06-20 | 2003-06-19 | Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase |
Country Status (27)
Country | Link |
---|---|
US (4) | US20040049032A1 (en) |
EP (4) | EP2292614A1 (en) |
JP (5) | JP4237701B2 (en) |
KR (2) | KR101141959B1 (en) |
CN (1) | CN100484934C (en) |
AR (1) | AR040286A1 (en) |
AT (2) | ATE556068T1 (en) |
AU (1) | AU2003245568B2 (en) |
BR (1) | BR0312443A (en) |
CA (1) | CA2489824C (en) |
CO (1) | CO5680433A2 (en) |
DE (1) | DE60336092D1 (en) |
EA (2) | EA015990B1 (en) |
EC (1) | ECSP055561A (en) |
ES (1) | ES2386781T3 (en) |
HK (3) | HK1077057A1 (en) |
HR (1) | HRP20050064A2 (en) |
IL (1) | IL165849A0 (en) |
IS (2) | IS7606A (en) |
MX (1) | MXPA05000068A (en) |
MY (1) | MY141867A (en) |
NO (2) | NO331925B1 (en) |
NZ (4) | NZ549142A (en) |
PL (1) | PL374953A1 (en) |
SG (1) | SG170614A1 (en) |
TW (2) | TWI354554B (en) |
WO (1) | WO2004000833A1 (en) |
Cited By (61)
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WO2005077938A1 (en) * | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
WO2007056221A2 (en) | 2005-11-03 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
US7226923B2 (en) | 2004-09-24 | 2007-06-05 | Hoffman-La Roche Inc. | Phthalazinone derivatives |
WO2007087276A1 (en) | 2006-01-23 | 2007-08-02 | Amgen Inc. | Aurora kinase modulators and method of use |
US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
WO2008038011A1 (en) * | 2006-09-30 | 2008-04-03 | Vernalis (R & D) Limited | Pyrimidine derivatives as aurora a and aurora b inhibitors |
EP1906967A2 (en) * | 2005-07-26 | 2008-04-09 | Vertex Pharmaceuticals, Inc. | Abl kinase inhibition |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP2008520713A (en) * | 2004-11-17 | 2008-06-19 | ミイカナ セラピューティクス インコーポレイテッド | Kinase inhibitor |
WO2008115973A2 (en) * | 2007-03-20 | 2008-09-25 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
WO2008124083A2 (en) | 2007-04-05 | 2008-10-16 | Amgen Inc. | Aurora kinase modulators and method of use |
WO2008137621A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
WO2008137619A2 (en) | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
WO2008147626A2 (en) * | 2007-05-24 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
US7462639B2 (en) | 2005-04-14 | 2008-12-09 | Hoffmann-La Roche Inc. | Aminopyrazole derivatives |
WO2008128009A3 (en) * | 2007-04-13 | 2009-01-08 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
WO2008137622A3 (en) * | 2007-05-02 | 2009-03-05 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
JP2009515992A (en) * | 2005-11-16 | 2009-04-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | Aminopyrimidines useful as kinase inhibitors |
WO2009065232A1 (en) * | 2007-11-20 | 2009-05-28 | University Health Network | Cancer diagnostic and therapeutic methods that target plk4/sak |
WO2009073224A1 (en) * | 2007-12-07 | 2009-06-11 | Ambit Biosciences Corp. | Methods of treating certain diseases using pyrimidine derivatives |
WO2010019473A1 (en) * | 2008-08-14 | 2010-02-18 | Amgen Inc. | Aurora kinase modulators and methods of use |
US7691853B2 (en) | 2000-09-15 | 2010-04-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
WO2010074724A1 (en) | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
US7872129B2 (en) | 2002-08-02 | 2011-01-18 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of GSK-3 |
US7951820B2 (en) | 2000-09-15 | 2011-05-31 | Vertex Pharmaceuticals Incorporated | Triazole compounds useful as protein kinase inhibitors |
US8022221B2 (en) | 2006-01-23 | 2011-09-20 | Amgen Inc. | Aurora kinase modulators and method of use |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
US8211929B2 (en) | 2004-12-30 | 2012-07-03 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
US8222256B2 (en) | 2006-07-05 | 2012-07-17 | Exelixis, Inc. | Methods of using IGFIR and ABL kinase modulators |
US8236823B2 (en) | 2006-10-27 | 2012-08-07 | Amgen Inc. | Multi-cyclic compounds and methods of use |
US8268829B2 (en) | 2002-06-20 | 2012-09-18 | Vertex Pharmaceuticals Inc. | Substituted pyrimidines useful as protein kinase inhibitors |
US8278450B2 (en) | 2007-04-18 | 2012-10-02 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US8288536B2 (en) | 2004-10-15 | 2012-10-16 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US8304414B2 (en) | 2000-12-21 | 2012-11-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US8372971B2 (en) | 2004-08-25 | 2013-02-12 | Targegen, Inc. | Heterocyclic compounds and methods of use |
US8404694B2 (en) | 2008-03-20 | 2013-03-26 | Amgen Inc. | Aurora kinase modulators and method of use |
US8410133B2 (en) | 2007-03-09 | 2013-04-02 | Vertex Pharmaceuticals Incorporated | Aminopyridines useful as inhibitors of protein kinases |
US8481536B2 (en) | 2004-04-08 | 2013-07-09 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
US8518953B2 (en) | 2007-03-09 | 2013-08-27 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
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US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
US8669081B2 (en) | 2002-03-15 | 2014-03-11 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
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