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Long-Term Outcome of Children of Rheumatic Disease Patients

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Contraception and Pregnancy in Patients with Rheumatic Disease

Abstract

Systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome are systemic autoimmune diseases that primarily affect woman of childbearing age. Affected patients can have children; however, their pregnancies are often complicated by maternal and fetal problems. Among these, the most frequent is prematurity, often related to the presence of antiphospholipid antibodies (aPL). Maternal aPL (IgG isotype) can cross the placenta but they do not generally cause any thrombotic event in the neonates; on the other hand, there are other maternal antibodies involved in fetal problems, for example anti-Ro/SSA and anti-La/SSB can cause congenital heart block. Behavior and neuropsychological outcomes of children born to patients with SLE and APS have been a matter of interest although limited data are now available. Common experience of experts in the field is that these children do not show an increased risk of autoimmune disease as in their mothers, and that maternal disease does not seems to impair their intelligence levels.

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Authors and Affiliations

  1. Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, Brescia, 25133, Italy

    Cecilia Nalli M.D., Rossella Reggia M.D., Laura Andreoli M.D. & Angela Tincani M.D.

  2. Unit of Child and Adolescent Neuropsychiatry, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, Brescia, 25133, Italy

    Alessandro Iodice M.D. & Elisa Fazzi M.D.

  3. Obstetrics and Gynecology, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, Brescia, 25133, Italy

    Andrea Lojacono M.D.

  4. Neonatology and NICU, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, Brescia, 25133, Italy

    Mario Motta M.D.

  5. Unit of Pediatric Immunology and Rheumatology, Pediatric Clinic, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, Brescia, 25133, Italy

    Antonella Meini M.D.

Authors
  1. Cecilia Nalli M.D.
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  2. Alessandro Iodice M.D.
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  3. Rossella Reggia M.D.
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  4. Laura Andreoli M.D.
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  5. Andrea Lojacono M.D.
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  6. Mario Motta M.D.
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  7. Antonella Meini M.D.
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  8. Elisa Fazzi M.D.
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  9. Angela Tincani M.D.
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Corresponding author

Correspondence to Angela Tincani M.D. .

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Editors and Affiliations

  1. Division of Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, New York, USA

    Lisa R. Sammaritano

  2. Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Bonnie L. Bermas

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Nalli, C. et al. (2014). Long-Term Outcome of Children of Rheumatic Disease Patients. In: Sammaritano, L., Bermas, B. (eds) Contraception and Pregnancy in Patients with Rheumatic Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0673-4_15

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