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G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk

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Abstract

Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor for cardiovascular events such as stroke and myocardial infarction. The subunits of the heterotrimeric G proteins are attractive candidate gene products for both susceptibility to essential hypertension and interindividual variations in blood pressure. A polymorphism (825C/T) in exon 10 of the GNB3 gene, encoding for the Gβ3 subunit, has recently been described. The 825T allele is associated with alternative splicing of the gene and formation of a truncated but functionally active β3 subunit. Carriers of the 825T allele appear to be at an increased risk of hypertension, obesity, insulin resistance and left ventricular hypertrophy. Moreover, 825T allele carriers respond with a larger decrease in blood pressure to therapy with a thiazide diuretic and with clonidine. The GNB3 825T allele may be regarded as a potential genetic marker for better defining the risk profile of hypertensive patients, but further studies are needed to precisely define the impact of the T allele on the prognosis of hypertensive patients.

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Acknowledgements

This review was supported in part by a grant from the Italian Society of Hypertension to Michelangelo Sartori. There are no conflicts of interest.

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  1. Clinica Medica 4, Department of Clinical and Experimental Medicine, Policlinico Universitario, via Giustiniani 2, 35128, Padova, Italy

    Michelangelo Sartori, Emanuela Parotto, Elisa Pagnin, Francesca Cattelan, Giulio Ceolotto, Italia Papparella, Livia Lenzini, Lorenzo A. Calò &  Andrea Semplicini

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  1. Michelangelo Sartori
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Correspondence to Andrea Semplicini.

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Sartori, M., Parotto, E., Pagnin, E. et al. G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk. High Blood Press Cardiovasc Prev 11, 107–112 (2004). https://doi.org/10.2165/00151642-200411030-00003

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