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Situation Report on mcr-Carrying Colistin-Resistant Clones of Enterobacterales: A Global Update Through Human-Animal-Environment Interfaces

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Abstract

In the twenty-first century, antibiotic resistance (ABR) is one of the acute medical emergencies around the globe, overwhelming human-animal-environmental interfaces. Hit-or-mis use of antibiotics exacerbates the crisis of ABR, dispersing transferable resistance traits and challenging treatment regimens based on life-saving drugs such as colistin. Colistin is the highest priority critically important antimicrobials for human medicine, but its long use as a growth promoter in animal husbandry reduces clinical efficacy. Since 2015, the emergence and spread of mobile colistin resistance (mcr)-carrying colistin-resistant clones of Enterobacterales have been markedly sustained in both humans and animals, especially in developing countries. Hospital and community transmissions of mcr clones pose a high risk for infection prevention and outbreaks at the national and international levels. Several public health and limited one health studies have highlighted the genomic insights of mcr clones, clarifying the chromosomal sequence types (STs) and plasmid incompatibility (Inc) types. But this information is segregated into humans and animals, and rarely are environmental sectors complicating the understanding of possibly intercontinental and sectoral transmission of these clones. India is the hotspot for superbugs, including mcr-carrying colistin-resistant isolates that threaten cross-border transmission. The current review provided an up-to-date worldwide scenario of mcr-carrying STs and plasmid Inc types among the Gram-negative bacilli of Enterobacterales across human-animal-environmental interfaces and correlated with the available information from India.

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Acknowledgements

The authors wish to thank Prof. Susanta Kumar Chakraborty, Vice-Chancellor, Vidyasagar University for his support in publication of this manuscript.

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  1. Biomedical Laboratory Science and Management, Vidyasagar University, Midnapore, West Bengal, 721102, India

    Urmy Biswas, Surojit Das, Mili Barik & Abhi Mallick

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  1. Urmy Biswas
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  2. Surojit Das
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UB: Writing draft and editing; SD: Conceptualization, format analysis, and editing; MB: Format analysis and data curation; AM: Writing and editing. All authors have read and approved the final version.

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Correspondence to Surojit Das.

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Biswas, U., Das, S., Barik, M. et al. Situation Report on mcr-Carrying Colistin-Resistant Clones of Enterobacterales: A Global Update Through Human-Animal-Environment Interfaces. Curr Microbiol 81, 12 (2024). https://doi.org/10.1007/s00284-023-03521-8

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