Rationale aims, and objectives: Clinical pathways (CP) have the ability to educate providers on guideline-driven recommendations and reduce readmission rates. The aim of this study was to evaluate adherence to the 2020 Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations for the management of an AECOPD after the implementation of an educational CP. Methods: This study was an observational quality improvement study targeting COPD exacerbation hospitalizations with a three-month pre-intervention period from January to March 2020 and a five-month post-intervention period from January to May 2021, following the implementation of a CP. Patients were included if they were hospitalized with a primary diagnosis of an AECOPD. The primary endpoint was to assess adherence to guideline recommendations. Secondary endpoints included an evaluation of oxygen support requirement, hospital length of stay (LOS), 30-day readmission rates, admission to the intensive care unit (ICU), and requirement of mechanical ventilation (MV). Results: There were a total of 78 patients included in this study. There was a significant improvement in guideline appropriate inhalers prescribed at discharge [85%, n=24 vs. 44%, n=22, p=0.01], antibiotic therapy for an AECOPD [90%, n=25 vs. 61%, n =30, p =0.02], smoking cessation pharmacotherapy [80%, n=22 vs. 29%, n=14, p=0.004] and counseling [89%, n=25 vs.15%, n=8, p=0.002] prior to discharge within the post-intervention group compared to the pre-intervention group. A significant reduction in the requirement of oxygen support was demonstrated within the post-intervention group after the implementation of a CP (p=0.03). Conclusion: The implementation of a CP can improve adherence to guideline recommendations and reduce the need of oxygen support for the management of AECOPD.