ID:ENTP8_HUMAN DESCRIPTION: RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 8; Short=E-NTPDase 8; Short=NTPDase 8; Short=NTPDase8; EC=3.6.1.5; FUNCTION: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. CATALYTIC ACTIVITY: ATP + 2 H(2)O = AMP + 2 phosphate. COFACTOR: Calcium (By similarity). ENZYME REGULATION: Not inhibited by ARL 67156. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=81 uM for ATP; KM=137 uM for ADP; KM=480 uM for UTP; KM=241 uM for UDP; Vmax=790 nmol/min/mg enzyme with ATP as substrate; Vmax=163 nmol/min/mg enzyme with ADP as substrate; Vmax=1100 nmol/min/mg enzyme with UTP as substrate; Vmax=110 nmol/min/mg enzyme with UDP as substrate; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). DOMAIN: The transmembranous domains are involved in regulation of enzyme activity. PTM: N-glycosylated. SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01150 - GDA1/CD39 (nucleoside phosphatase) family
ModBase Predicted Comparative 3D Structure on Q5MY95
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0009124 nucleoside monophosphate biosynthetic process GO:0009133 nucleoside diphosphate biosynthetic process GO:0034656 nucleobase-containing small molecule catabolic process
US Server
Sequence and Links to Tools and Databases 
